GREMLIN Database
MANC - Mannose-1-phosphate guanylyltransferase
UniProt: P24174 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10161
Length: 478 (465)
Sequences: 2094 (1522)
Seq/√Len: 70.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_V328_L5.4311.00
186_N189_T5.0291.00
418_K445_E4.2201.00
187_L191_Q4.1311.00
191_Q195_A4.0161.00
265_T268_A3.9361.00
38_L46_C3.6321.00
162_R179_A3.5801.00
112_L207_L3.5531.00
308_T311_S3.5391.00
218_K229_E3.5391.00
422_D440_A3.4971.00
102_A113_M3.4551.00
309_E326_K3.4471.00
344_A347_D3.4291.00
97_L244_V3.4261.00
178_V268_A3.3441.00
308_T322_T3.2651.00
421_I424_D3.1911.00
100_L225_L2.9231.00
418_K425_I2.8211.00
96_A217_L2.7431.00
332_Q337_V2.7411.00
347_D350_K2.6981.00
318_G332_Q2.6981.00
322_T330_V2.6491.00
189_T192_A2.6361.00
216_E265_T2.6241.00
162_R180_Q2.6221.00
426_K434_I2.5681.00
224_I255_E2.5471.00
110_D211_G2.5301.00
163_R200_Y2.4631.00
162_R198_E2.4191.00
36_G43_T2.4121.00
307_K344_A2.3531.00
429_G432_E2.3181.00
402_M471_F2.3101.00
9_V98_A2.2611.00
42_Q71_Q2.2561.00
302_D360_R2.2431.00
313_V320_V2.2301.00
219_K266_A2.2251.00
327_D341_D2.2141.00
296_G310_N2.1791.00
368_E377_D2.1611.00
313_V322_T2.1561.00
421_I434_I2.1531.00
400_V443_C2.1421.00
299_C305_N2.1341.00
95_I115_V2.0891.00
97_L228_C2.0821.00
143_K267_D2.0311.00
138_Y175_A2.0221.00
310_N327_D1.9911.00
441_T471_F1.9851.00
125_E129_R1.9521.00
354_Q358_D1.9441.00
245_D248_A1.9011.00
87_A250_L1.8971.00
313_V330_V1.8561.00
164_G167_S1.8201.00
143_K269_V1.8041.00
221_R255_E1.8011.00
196_S199_Y1.7751.00
200_Y270_V1.7741.00
402_M469_V1.7641.00
421_I426_K1.7521.00
114_L207_L1.7301.00
161_I270_V1.7271.00
45_I72_L1.7241.00
235_V242_I1.7221.00
225_L229_E1.7181.00
111_P211_G1.7021.00
420_T425_I1.6951.00
367_R377_D1.6731.00
162_R199_Y1.6721.00
397_G445_E1.6691.00
215_E218_K1.6601.00
305_N313_V1.6550.99
324_G344_A1.6420.99
414_A453_D1.6170.99
234_A245_D1.6140.99
182_V193_Y1.6050.99
97_L232_M1.6010.99
46_C75_L1.5900.99
143_K177_E1.5810.99
350_K353_E1.5800.99
421_I440_A1.5650.99
326_K341_D1.5500.99
284_S288_E1.5480.99
368_E375_K1.5450.99
218_K225_L1.5440.99
280_V289_I1.5200.99
213_Y217_L1.5190.99
306_H354_Q1.5180.99
290_S298_V1.5170.99
90_N254_E1.5150.99
375_K391_T1.5070.99
420_T445_E1.5060.99
163_R176_F1.4950.99
112_L136_M1.4690.99
402_M441_T1.4630.99
473_D477_R1.4630.99
213_Y257_V1.4590.99
378_S386_Q1.4580.99
322_T325_V1.4530.99
329_V345_V1.4390.99
188_E191_Q1.4330.99
310_N326_K1.4210.98
25_V364_R1.4160.98
212_R267_D1.4110.98
287_W292_H1.4000.98
238_D243_R1.3970.98
430_E461_S1.3750.98
38_L43_T1.3630.98
411_V457_V1.3600.98
60_C64_H1.3440.98
11_M117_A1.3350.98
227_A248_A1.3330.98
155_E346_Q1.3310.98
57_V102_A1.3300.98
221_R224_I1.3230.97
232_M235_V1.3200.97
418_K447_P1.3180.97
154_P187_L1.3160.97
341_D344_A1.2970.97
192_A196_S1.2930.97
124_D274_D1.2930.97
193_Y199_Y1.2880.97
124_D127_A1.2800.97
96_A213_Y1.2720.97
42_Q75_L1.2710.97
306_H350_K1.2680.97
384_R430_E1.2650.97
167_S269_V1.2610.97
209_R212_R1.2600.97
378_S381_A1.2600.97
316_E332_Q1.2530.97
99_A113_M1.2480.96
377_D380_D1.2430.96
165_E177_E1.2410.96
43_T46_C1.2370.96
404_H450_I1.2370.96
224_I253_P1.2370.96
106_S111_P1.2310.96
112_L139_A1.2250.96
381_A386_Q1.2240.96
20_W336_A1.2190.96
229_E233_S1.2110.96
189_T193_Y1.2110.96
462_Y466_D1.2040.96
115_V208_F1.1990.95
416_T427_L1.1910.95
404_H469_V1.1860.95
164_G176_F1.1840.95
388_K465_E1.1810.95
437_P440_A1.1800.95
376_Y388_K1.1790.95
380_D387_V1.1790.95
315_A320_V1.1720.95
65_R241_F1.1630.95
70_E73_R1.1600.95
284_S345_V1.1570.95
308_T325_V1.1540.94
238_D241_F1.1530.94
101_A232_M1.1520.94
69_A240_N1.1490.94
208_F213_Y1.1320.94
132_V207_L1.1300.94
401_Q442_H1.1290.94
330_V339_I1.1290.94
139_A145_V1.1280.94
306_H351_V1.1250.94
123_A276_G1.1250.94
41_L58_V1.1120.93
305_N322_T1.1120.93
399_S470_R1.1030.93
83_I101_A1.1030.93
164_G177_E1.1020.93
376_Y390_I1.0960.93
305_N308_T1.0930.93
149_I203_S1.0920.93
334_K377_D1.0910.93
116_L205_M1.0860.92
416_T450_I1.0850.92
405_H447_P1.0780.92
31_F68_V1.0770.92
223_D255_E1.0760.92
239_L243_R1.0730.92
420_T443_C1.0610.92
328_L341_D1.0600.92
223_D253_P1.0580.91
224_I254_E1.0570.91
144_L212_R1.0570.91
308_T313_V1.0540.91
431_N459_S1.0520.91
102_A111_P1.0490.91
405_H450_I1.0470.91
162_R196_S1.0380.91
127_A131_A1.0360.91
397_G474_R1.0340.90
404_H449_K1.0300.90
329_V342_R1.0270.90
216_E267_D1.0250.90
95_I208_F1.0200.90
58_V68_V1.0150.90
412_V454_L1.0130.90
396_E474_R1.0120.90
144_L265_T1.0110.89
31_F41_L1.0110.89
92_A260_A1.0110.89
221_R264_R1.0080.89
135_A207_L1.0080.89
138_Y269_V1.0070.89
7_Y111_P1.0020.89
161_I178_V0.9970.89
321_T351_V0.9960.89
376_Y465_E0.9950.89
430_E449_K0.9920.89
248_A251_A0.9910.89
91_T117_A0.9850.88
371_R388_K0.9820.88
419_V428_L0.9820.88
317_S332_Q0.9810.88
397_G443_C0.9800.88
304_I319_L0.9760.88
323_V348_V0.9730.88
295_E309_E0.9540.87
369_V376_Y0.9520.86
300_H314_Y0.9510.86
413_V455_I0.9500.86
134_N174_V0.9480.86
130_A133_R0.9460.86
396_E475_Y0.9460.86
218_K226_D0.9420.86
134_N137_P0.9400.86
236_D245_D0.9400.86
164_G179_A0.9390.86
398_L444_L0.9390.86
429_G438_L0.9370.86
6_L136_M0.9370.86
121_V289_I0.9350.85
376_Y398_L0.9330.85
101_A104_R0.9330.85
256_S259_Y0.9320.85
217_L261_V0.9300.85
304_I354_Q0.9290.85
7_Y102_A0.9280.85
411_V454_L0.9240.85
388_K468_V0.9240.85
390_I398_L0.9220.85
428_L432_E0.9180.84
124_D130_A0.9180.84
216_E219_K0.9180.84
106_S110_D0.9180.84
150_V274_D0.9130.84
402_M418_K0.9080.84
115_V144_L0.9060.84
404_H447_P0.9050.84
10_V45_I0.9000.83
65_R82_I0.9000.83
62_E243_R0.9000.83
136_M140_E0.9000.83
69_A82_I0.8990.83
140_E209_R0.8980.83
213_Y261_V0.8980.83
432_E435_Y0.8950.83
50_G129_R0.8900.82
62_E246_E0.8870.82
228_C252_C0.8840.82
136_M207_L0.8830.82
113_M210_A0.8810.82
223_D226_D0.8790.82
65_R238_D0.8790.82
131_A271_V0.8780.82
320_V337_V0.8780.82
370_Y375_K0.8780.82
349_K353_E0.8710.81
323_V351_V0.8710.81
365_V369_V0.8650.81
404_H427_L0.8640.81
144_L213_Y0.8640.81
8_P56_P0.8630.80
299_C313_V0.8620.80
401_Q465_E0.8590.80
214_L225_L0.8580.80
386_Q464_E0.8560.80
99_A213_Y0.8510.80
227_A252_C0.8500.79
215_E219_K0.8490.79
473_D476_G0.8460.79
70_E393_K0.8440.79
144_L208_F0.8420.79
286_L312_Y0.8400.79
399_S458_R0.8380.79
465_E468_V0.8370.78
401_Q458_R0.8370.78
106_S211_G0.8330.78
384_R449_K0.8310.78
389_R453_D0.8280.78
371_R455_I0.8270.78
287_W298_V0.8270.78
285_S298_V0.8270.78
322_T328_L0.8270.78
215_E267_D0.8260.78
216_E268_A0.8250.77
44_T47_R0.8230.77
102_A210_A0.8180.77
59_I88_G0.8170.77
45_I75_L0.8170.77
391_T451_P0.8150.77
27_Y67_I0.8140.76
100_L228_C0.8140.76
130_A134_N0.8090.76
384_R448_G0.8090.76
212_R215_E0.8090.76
104_R233_S0.8080.76
376_Y386_Q0.8070.76
100_L229_E0.8050.76
30_Q71_Q0.8050.76
416_T429_G0.8020.75
227_A253_P0.8000.75
224_I252_C0.7990.75
430_E448_G0.7970.75
177_E269_V0.7930.75
447_P450_I0.7930.75
388_K457_V0.7910.74
69_A73_R0.7900.74
399_S477_R0.7900.74
110_D209_R0.7880.74
439_G450_I0.7880.74
230_K234_A0.7860.74
58_V72_L0.7840.74
311_S328_L0.7810.73
412_V444_L0.7750.73
163_R198_E0.7740.73
302_D362_E0.7740.73
117_A205_M0.7730.73
287_W312_Y0.7710.73
414_A430_E0.7700.72
427_L450_I0.7690.72
220_Y264_R0.7660.72
22_L32_L0.7660.72
392_V398_L0.7660.72
320_V330_V0.7610.72
103_K214_L0.7610.72
128_F132_V0.7600.71
91_T205_M0.7590.71
311_S314_Y0.7590.71
427_L439_G0.7560.71
423_G426_K0.7540.71
299_C303_V0.7530.71
226_D230_K0.7510.71
383_D414_A0.7500.70
255_E264_R0.7500.70
443_C474_R0.7490.70
408_E442_H0.7430.70
304_I358_D0.7430.70
293_T297_N0.7410.69
13_G16_G0.7400.69
95_I257_V0.7370.69
231_A235_V0.7360.69
145_V271_V0.7350.69
371_R401_Q0.7320.69
35_K121_V0.7320.69
384_R450_I0.7320.69
465_E470_R0.7310.68
16_G19_L0.7260.68
22_L314_Y0.7250.68
307_K347_D0.7240.68
7_Y12_A0.7240.68
99_A214_L0.7210.67
420_T423_G0.7200.67
398_L468_V0.7200.67
65_R243_R0.7190.67
416_T449_K0.7180.67
137_P141_A0.7160.67
60_C68_V0.7160.67
7_Y106_S0.7160.67
142_G209_R0.7160.67
380_D389_R0.7160.67
393_K396_E0.7150.67
40_M286_L0.7140.67
388_K401_Q0.7130.67
133_R136_M0.7110.66
26_L365_V0.7100.66
164_G269_V0.7100.66
400_V441_T0.7090.66
135_A271_V0.7070.66
424_D434_I0.7070.66
33_C39_T0.7070.66
348_V352_V0.7060.66
193_Y227_A0.7050.66
327_D343_N0.7050.66
334_K368_E0.7050.66
353_E356_K0.7030.65
371_R470_R0.7020.65
66_F243_R0.7010.65
426_K432_E0.6970.65
114_L147_F0.6970.65
427_L447_P0.6960.65
128_F205_M0.6940.64
66_F241_F0.6940.64
436_I440_A0.6890.64
103_K106_S0.6880.64
416_T448_G0.6880.64
398_L458_R0.6880.64
145_V269_V0.6870.64
25_V356_K0.6840.63
315_A332_Q0.6820.63
186_N192_A0.6810.63
430_E450_I0.6800.63
16_G21_P0.6790.63
109_S214_L0.6780.63
388_K398_L0.6760.62
406_R467_D0.6730.62
384_R404_H0.6720.62
55_S81_N0.6710.62
81_N101_A0.6710.62
402_M440_A0.6710.62
100_L214_L0.6700.62
96_A228_C0.6700.62
390_I454_L0.6670.61
14_G18_R0.6670.61
351_V355_I0.6660.61
401_Q470_R0.6660.61
411_V431_N0.6640.61
401_Q468_V0.6640.61
14_G19_L0.6600.61
103_K210_A0.6590.60
167_S177_E0.6580.60
406_R460_G0.6570.60
247_E250_L0.6560.60
13_G18_R0.6550.60
102_A106_S0.6550.60
384_R447_P0.6550.60
372_P473_D0.6550.60
323_V338_L0.6540.60
428_L454_L0.6540.60
273_M332_Q0.6520.60
273_M318_G0.6520.60
371_R468_V0.6510.60
234_A248_A0.6490.59
319_L362_E0.6490.59
65_R69_A0.6490.59
307_K323_V0.6490.59
78_L81_N0.6480.59
180_Q199_Y0.6470.59
13_G19_L0.6470.59
146_T262_M0.6460.59
103_K211_G0.6460.59
292_H298_V0.6450.59
398_L477_R0.6450.59
192_A195_A0.6420.58
384_R427_L0.6420.58
6_L111_P0.6420.58
129_R132_V0.6410.58
82_I239_L0.6400.58
41_L280_V0.6400.58
422_D434_I0.6400.58
471_F475_Y0.6400.58
306_H311_S0.6400.58
403_H408_E0.6380.58
157_G346_Q0.6370.58
399_S473_D0.6370.58
104_R229_E0.6360.58
154_P198_E0.6360.58
404_H448_G0.6360.58
405_H427_L0.6350.58
427_L449_K0.6350.58
137_P425_I0.6340.57
127_A130_A0.6340.57
252_C255_E0.6340.57
380_D390_I0.6330.57
165_E179_A0.6330.57
88_G155_E0.6320.57
233_S295_E0.6310.57
39_T60_C0.6300.57
295_E307_K0.6300.57
39_T42_Q0.6270.57
240_N243_R0.6270.57
407_A459_S0.6270.57
212_R265_T0.6260.57
416_T430_E0.6260.57
24_R28_P0.6230.56
388_K413_V0.6230.56
95_I144_L0.6230.56
405_H462_Y0.6220.56
14_G21_P0.6200.56
339_I345_V0.6200.56
58_V78_L0.6190.56
417_A452_L0.6190.56
405_H416_T0.6170.55
304_I351_V0.6170.55
41_L44_T0.6170.55
90_N157_G0.6160.55
153_L284_S0.6160.55
445_E454_L0.6160.55
69_A241_F0.6140.55
7_Y54_E0.6140.55
444_L454_L0.6110.55
404_H416_T0.6110.55
13_G21_P0.6100.55
175_A280_V0.6100.55
443_C473_D0.6090.54
301_G319_L0.6080.54
255_E259_Y0.6080.54
194_V198_E0.6070.54
12_A117_A0.6070.54
232_M244_V0.6060.54
31_F117_A0.6030.54
95_I213_Y0.6030.54
58_V280_V0.6010.54
458_R464_E0.6010.54
377_D387_V0.6000.53
206_F258_D0.6000.53
143_K428_L0.6000.53
61_N66_F0.6000.53
283_W363_H0.6000.53
413_V435_Y0.5990.53
396_E450_I0.5980.53
149_I273_M0.5980.53
341_D345_V0.5960.53
372_P470_R0.5960.53
48_L116_L0.5950.53
422_D436_I0.5950.53
403_H406_R0.5940.53
18_R21_P0.5940.53
424_D440_A0.5940.53
427_L448_G0.5930.53
387_V407_A0.5930.53
158_Y285_S0.5910.52
225_L228_C0.5910.52
211_G215_E0.5900.52
132_V331_V0.5900.52
406_R458_R0.5890.52
403_H460_G0.5880.52
214_L229_E0.5870.52
90_N255_E0.5850.52
330_V337_V0.5850.52
458_R468_V0.5850.52
164_G175_A0.5850.52
116_L265_T0.5840.51
112_L209_R0.5840.51
444_L452_L0.5830.51
55_S79_T0.5830.51
57_V83_I0.5820.51
353_E357_A0.5820.51
56_P65_R0.5800.51
126_D130_A0.5790.51
400_V472_A0.5790.51
48_L128_F0.5780.51
401_Q408_E0.5780.51
122_I274_D0.5780.51
12_A68_V0.5780.51
16_G20_W0.5770.51
114_L128_F0.5760.50
376_Y399_S0.5760.50
407_A438_L0.5760.50
158_Y282_S0.5750.50
40_M43_T0.5740.50
393_K451_P0.5730.50
95_I282_S0.5730.50
325_V330_V0.5730.50
9_V99_A0.5720.50
135_A205_M0.5720.50
345_V348_V0.5710.50
230_K233_S0.5710.50
388_K477_R0.5700.50
12_A345_V0.5700.50
286_L360_R0.5690.50
390_I458_R0.5690.50
67_I71_Q0.5680.50
118_A345_V0.5650.49
386_Q398_L0.5650.49
399_S468_V0.5650.49
371_R399_S0.5640.49
131_A273_M0.5640.49
100_L232_M0.5630.49
125_E230_K0.5620.49
188_E192_A0.5600.49
101_A105_H0.5590.48
26_L31_F0.5590.48
182_V189_T0.5590.48
226_D229_E0.5580.48
240_N244_V0.5570.48
342_R349_K0.5560.48
395_G416_T0.5550.48
23_S29_K0.5540.48
377_D391_T0.5530.48
376_Y477_R0.5530.48
456_E467_D0.5530.48
390_I477_R0.5530.48
375_K385_Y0.5520.48
444_L464_E0.5510.47
401_Q406_R0.5510.47
39_T364_R0.5500.47
334_K367_R0.5500.47
63_Q73_R0.5480.47
399_S465_E0.5470.47
303_V311_S0.5460.47
428_L457_V0.5450.47
11_M14_G0.5450.47
11_M19_L0.5450.47
443_C472_A0.5450.47
35_K43_T0.5440.47
405_H449_K0.5430.46
67_I254_E0.5430.46
388_K399_S0.5420.46
42_Q74_Q0.5420.46
57_V98_A0.5410.46
427_L454_L0.5410.46
402_M459_S0.5390.46
418_K427_L0.5390.46
419_V434_I0.5380.46
306_H347_D0.5380.46
83_I97_L0.5380.46
165_E215_E0.5370.46
12_A334_K0.5370.46
388_K392_V0.5360.46
40_M46_C0.5360.46
290_S314_Y0.5350.46
399_S475_Y0.5350.46
153_L288_E0.5340.45
320_V332_Q0.5340.45
386_Q399_S0.5340.45
361_H365_V0.5340.45
287_W342_R0.5340.45
406_R442_H0.5330.45
184_K263_E0.5330.45
405_H448_G0.5330.45
278_S457_V0.5330.45
398_L473_D0.5320.45
175_A272_P0.5320.45
390_I475_Y0.5320.45
46_C226_D0.5320.45
72_L259_Y0.5310.45
375_K443_C0.5300.45
55_S126_D0.5290.45
392_V468_V0.5280.45
406_R456_E0.5270.45
213_Y267_D0.5260.44
403_H467_D0.5260.44
371_R389_R0.5260.44
426_K435_Y0.5240.44
101_A244_V0.5230.44
72_L79_T0.5220.44
289_I348_V0.5220.44
43_T125_E0.5220.44
399_S408_E0.5210.44
444_L473_D0.5210.44
280_V320_V0.5210.44
157_G205_M0.5200.44
61_N203_S0.5200.44
223_D227_A0.5200.44
141_A271_V0.5200.44
131_A276_G0.5190.44
69_A243_R0.5190.44
56_P386_Q0.5190.44
22_L267_D0.5180.43
15_S34_L0.5170.43
41_L68_V0.5160.43
442_H458_R0.5160.43
195_A230_K0.5150.43
114_L132_V0.5140.43
390_I399_S0.5140.43
296_G300_H0.5140.43
434_I439_G0.5140.43
404_H430_E0.5140.43
131_A275_A0.5130.43
74_Q228_C0.5130.43
319_L360_R0.5120.43
410_W442_H0.5110.43
315_A319_L0.5110.43
14_G20_W0.5110.43
160_Y263_E0.5110.43
386_Q465_E0.5090.42
284_S343_N0.5090.42
285_S316_E0.5080.42
42_Q46_C0.5080.42
154_P237_P0.5080.42
61_N88_G0.5070.42
392_V419_V0.5070.42
273_M314_Y0.5070.42
115_V437_P0.5070.42
65_R84_L0.5060.42
11_M16_G0.5060.42
48_L53_C0.5050.42
143_K167_S0.5050.42
449_K461_S0.5050.42
422_D441_T0.5030.42
289_I355_I0.5030.42
116_L128_F0.5020.42
416_T438_L0.5020.42
430_E437_P0.5010.41
443_C477_R0.5000.41
59_I115_V0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x65A 2 0.6904 100 0.548 Contact Map
2cu2A 2 0.6925 100 0.555 Contact Map
2qh5A 1 0.5272 100 0.714 Contact Map
3jukA 3 0.5188 100 0.844 Contact Map
2e3dA 3 0.5544 100 0.844 Contact Map
2ux8A 4 0.5502 100 0.85 Contact Map
2pa4A 3 0.5711 100 0.853 Contact Map
1yp2A 4 0.795 100 0.853 Contact Map
3pnnA 1 0.5649 100 0.855 Contact Map
1lvwA 3 0.6088 100 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.013 seconds.