GREMLIN Database
RFAC - Lipopolysaccharide heptosyltransferase 1
UniProt: P24173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11189
Length: 319 (299)
Sequences: 5687 (4603)
Seq/√Len: 266.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D87_Y4.3341.00
182_V254_A3.9971.00
205_L313_L3.3831.00
53_R85_E3.2331.00
183_F203_I2.9841.00
256_F316_L2.9511.00
25_Q52_E2.8381.00
32_K52_E2.6531.00
200_R232_G2.6511.00
265_S277_T2.6501.00
198_H309_S2.6381.00
243_S246_G2.6151.00
138_Q146_E2.5001.00
32_K53_R2.4741.00
196_E228_R2.4681.00
223_E227_K2.4141.00
195_P198_H2.3991.00
182_V251_L2.2981.00
202_L313_L2.2681.00
199_W260_V2.2671.00
182_V217_W2.2501.00
247_V264_L2.2391.00
3_V31_I2.1941.00
14_V45_P2.1941.00
179_E255_K2.1691.00
202_L258_V2.1401.00
180_Y253_G2.0671.00
42_A46_S1.9981.00
259_S265_S1.9881.00
178_G212_R1.9861.00
181_A206_L1.9681.00
204_G233_F1.9311.00
194_W312_V1.9111.00
194_W198_H1.9091.00
34_D52_E1.8881.00
226_A239_L1.8571.00
310_Q314_E1.8551.00
34_D53_R1.8431.00
17_T93_A1.8401.00
110_V130_R1.8361.00
20_A93_A1.8291.00
299_A311_A1.8231.00
215_L226_A1.8221.00
205_L310_Q1.8101.00
4_L36_V1.8021.00
205_L209_S1.7621.00
34_D55_I1.7461.00
308_N311_A1.7181.00
248_A267_L1.7131.00
227_K231_E1.6941.00
302_E306_N1.6671.00
181_A256_F1.6461.00
5_I21_L1.6431.00
34_D85_E1.6411.00
39_E58_A1.6251.00
181_A211_I1.6231.00
198_H201_E1.6041.00
146_E150_K1.5911.00
180_Y255_K1.5891.00
207_A234_A1.5871.00
43_Q46_S1.5861.00
258_V316_L1.5851.00
180_Y254_A1.5721.00
257_V273_R1.5541.00
159_T162_D1.5511.00
148_F154_Y1.5201.00
201_E204_G1.5111.00
180_Y214_K1.4991.00
76_K80_E1.4821.00
194_W199_W1.4461.00
237_E240_P1.4161.00
104_T111_K1.4111.00
251_L271_L1.4071.00
295_M315_K1.3971.00
167_Q253_G1.3751.00
187_T193_H1.3461.00
25_Q33_F1.3461.00
218_G240_P1.3421.00
22_T26_Q1.3381.00
184_L262_T1.3341.00
90_V103_V1.3301.00
184_L259_S1.3281.00
227_K237_E1.3161.00
193_H225_R1.3081.00
185_H215_L1.3071.00
22_T50_A1.2931.00
205_L208_D1.2811.00
226_A237_E1.2781.00
179_E211_I1.2741.00
42_A54_V1.2641.00
228_R232_G1.2611.00
217_W247_V1.2481.00
28_I31_I1.2471.00
201_E205_L1.2341.00
257_V268_T1.2331.00
195_P305_I1.2291.00
169_F173_L1.2221.00
162_D245_E1.2191.00
200_R204_G1.2191.00
165_I246_G1.2171.00
256_F276_I1.2081.00
278_V307_L1.2061.00
180_Y212_R1.2031.00
20_A148_F1.2031.00
16_H287_I1.1991.00
200_R233_F1.1991.00
192_K261_D1.1971.00
202_L309_S1.1871.00
205_L309_S1.1871.00
194_W202_L1.1861.00
212_R236_V1.1841.00
220_P223_E1.1701.00
42_A56_P1.1701.00
124_A128_Y1.1691.00
186_A222_E1.1681.00
108_H111_K1.1611.00
18_L48_H1.1601.00
21_L35_W1.1591.00
203_I215_L1.1571.00
161_G165_I1.1571.00
47_W245_E1.1531.00
163_Y252_A1.1501.00
206_L313_L1.1501.00
89_A112_H1.1451.00
35_W45_P1.1311.00
228_R231_E1.1231.00
182_V250_V1.1191.00
223_E241_K1.1111.00
79_R83_Q1.1101.00
14_V41_F1.1071.00
251_L273_R1.1041.00
3_V33_F1.1031.00
92_D99_S1.0931.00
4_L87_Y1.0861.00
142_E290_Y1.0711.00
161_G164_A1.0641.00
227_K230_A1.0621.00
258_V276_I1.0601.00
259_S277_T1.0591.00
201_E309_S1.0561.00
196_E229_L1.0451.00
202_L205_L1.0451.00
203_I233_F1.0401.00
90_V108_H1.0391.00
200_R229_L1.0341.00
311_A314_E1.0281.00
276_I315_K1.0271.00
37_V54_V1.0271.00
25_Q31_I1.0241.00
141_V290_Y1.0171.00
204_G208_D1.0141.00
311_A315_K1.0101.00
307_L311_A1.0081.00
138_Q142_E1.0041.00
14_V35_W0.9981.00
230_A237_E0.9941.00
46_S245_E0.9851.00
10_S188_T0.9821.00
186_A225_R0.9771.00
217_W254_A0.9761.00
194_W309_S0.9681.00
184_L217_W0.9671.00
23_D26_Q0.9651.00
184_L257_V0.9651.00
284_P298_R0.9641.00
201_E310_Q0.9551.00
89_A110_V0.9531.00
209_S313_L0.9481.00
23_D27_A0.9381.00
168_H172_N0.9371.00
43_Q245_E0.9351.00
111_K129_N0.9351.00
183_F258_V0.9331.00
248_A271_L0.9301.00
291_G294_Q0.9291.00
197_E305_I0.9291.00
6_V36_V0.9191.00
103_V111_K0.9171.00
166_A170_L0.9151.00
299_A306_N0.9101.00
15_L267_L0.9101.00
125_S131_K0.9081.00
35_W51_V0.9081.00
198_H308_N0.9051.00
252_A273_R0.9051.00
278_V312_V0.9041.00
4_L90_V0.9001.00
310_Q313_L0.8991.00
224_E227_K0.8981.00
3_V89_A0.8971.00
11_M41_F0.8971.00
193_H260_V0.8961.00
276_I295_M0.8941.00
73_A77_A0.8921.00
162_D165_I0.8901.00
27_A154_Y0.8901.00
235_Y240_P0.8891.00
192_K282_T0.8831.00
222_E225_R0.8831.00
180_Y211_I0.8831.00
249_R252_A0.8821.00
278_V297_C0.8811.00
39_E42_A0.8801.00
11_M244_L0.8791.00
165_I168_H0.8791.00
162_D166_A0.8731.00
107_A111_K0.8691.00
31_I88_D0.8641.00
186_A193_H0.8641.00
242_M250_V0.8631.00
214_K250_V0.8601.00
165_I169_F0.8601.00
53_R81_A0.8581.00
160_Q164_A0.8571.00
206_L316_L0.8541.00
301_R306_N0.8531.00
197_E228_R0.8521.00
139_H290_Y0.8501.00
163_Y166_A0.8491.00
128_Y131_K0.8461.00
304_L307_L0.8431.00
79_R105_R0.8410.99
124_A129_N0.8370.99
237_E241_K0.8370.99
210_G213_I0.8360.99
211_I255_K0.8350.99
125_S128_Y0.8340.99
207_A213_I0.8320.99
181_A258_V0.8280.99
150_K155_S0.8280.99
139_H288_G0.8250.99
80_E84_A0.8230.99
186_A260_V0.8220.99
5_I24_A0.8210.99
187_T260_V0.8200.99
139_H142_E0.8190.99
130_R133_H0.8190.99
7_K10_S0.8160.99
261_D279_Y0.8140.99
9_S94_Q0.8130.99
101_A105_R0.8080.99
224_E228_R0.8010.99
178_G210_G0.7990.99
218_G237_E0.7970.99
126_L130_R0.7970.99
251_L257_V0.7840.99
7_K14_V0.7830.99
276_I316_L0.7800.99
23_D145_R0.7770.99
203_I229_L0.7740.99
167_Q170_L0.7730.99
199_W203_I0.7680.99
106_L111_K0.7660.99
10_S14_V0.7580.99
265_S279_Y0.7550.99
265_S275_N0.7540.99
191_D303_N0.7540.99
159_T163_Y0.7520.99
25_Q50_A0.7500.99
238_V242_M0.7420.99
140_A143_R0.7420.99
90_V106_L0.7410.99
15_L270_A0.7320.99
297_C307_L0.7280.99
194_W308_N0.7260.99
219_A222_E0.7230.98
125_S129_N0.7190.98
18_L270_A0.7180.98
160_Q163_Y0.7160.98
242_M246_G0.7140.98
100_A113_G0.7140.98
309_S313_L0.7100.98
161_G166_A0.7090.98
275_N294_Q0.7090.98
10_S94_Q0.7090.98
215_L235_Y0.7070.98
45_P48_H0.7050.98
82_L106_L0.7030.98
182_V257_V0.7030.98
128_Y132_H0.6990.98
77_A80_E0.6970.98
206_L211_I0.6920.98
302_E305_I0.6890.98
142_E146_E0.6880.98
186_A219_A0.6870.98
113_G116_W0.6850.98
200_R203_I0.6830.98
74_E77_A0.6820.98
106_L109_G0.6780.98
198_H305_I0.6760.98
100_A124_A0.6740.98
24_A31_I0.6690.97
226_A230_A0.6690.97
12_G266_H0.6680.97
38_E41_F0.6670.97
6_V90_V0.6660.97
194_W278_V0.6660.97
19_P145_R0.6650.97
218_G241_K0.6650.97
47_W249_R0.6640.97
3_V28_I0.6620.97
103_V106_L0.6620.97
251_L267_L0.6610.97
124_A127_F0.6610.97
207_A235_Y0.6580.97
140_A286_L0.6580.97
185_H229_L0.6580.97
184_L287_I0.6570.97
229_L233_F0.6560.97
166_A249_R0.6540.97
126_L129_N0.6510.97
166_A169_F0.6500.97
167_Q171_T0.6460.97
195_P304_L0.6450.97
189_R192_K0.6430.97
238_V241_K0.6410.97
196_E200_R0.6390.97
39_E56_P0.6340.97
150_K153_G0.6330.96
276_I312_V0.6270.96
112_H132_H0.6260.96
281_P304_L0.6250.96
32_K87_Y0.6240.96
10_S16_H0.6210.96
12_G263_G0.6190.96
7_K17_T0.6150.96
249_R253_G0.6120.96
48_H51_V0.6110.96
155_S158_Q0.6110.96
181_A213_I0.6110.96
55_I85_E0.6100.96
254_A273_R0.6090.96
313_L316_L0.6090.96
198_H202_L0.6070.96
185_H262_T0.6070.96
252_A271_L0.6060.96
183_F202_L0.6060.96
103_V108_H0.6060.96
275_N291_G0.6020.95
237_E242_M0.6000.95
28_I89_A0.5990.95
25_Q30_G0.5990.95
24_A33_F0.5970.95
218_G242_M0.5960.95
184_L264_L0.5960.95
26_Q157_P0.5920.95
223_E237_E0.5880.95
185_H226_A0.5870.95
151_S154_Y0.5870.95
14_V37_V0.5850.95
204_G207_A0.5850.95
114_M147_L0.5840.95
113_G117_Q0.5820.94
162_D170_L0.5820.94
77_A81_A0.5790.94
76_K83_Q0.5790.94
9_S38_E0.5760.94
9_S92_D0.5740.94
31_I89_A0.5730.94
170_L174_P0.5710.94
11_M15_L0.5690.94
193_H199_W0.5660.94
164_A167_Q0.5660.94
115_D133_H0.5640.93
15_L248_A0.5630.93
114_M118_T0.5620.93
5_I91_I0.5610.93
21_L50_A0.5610.93
242_M247_V0.5600.93
170_L175_T0.5600.93
289_G296_V0.5580.93
52_E85_E0.5580.93
217_W264_L0.5580.93
275_N279_Y0.5560.93
187_T262_T0.5550.93
7_K140_A0.5540.93
94_Q287_I0.5540.93
218_G239_L0.5520.93
278_V303_N0.5510.93
92_D95_G0.5500.93
18_L47_W0.5490.93
196_E225_R0.5490.93
137_Q143_R0.5480.92
16_H141_V0.5470.92
215_L229_L0.5470.92
58_A61_R0.5460.92
92_D96_L0.5460.92
73_A76_K0.5440.92
92_D103_V0.5430.92
269_A290_Y0.5420.92
103_V107_A0.5420.92
6_V103_V0.5410.92
183_F199_W0.5410.92
189_R281_P0.5400.92
177_A212_R0.5390.92
131_K134_I0.5380.92
265_S269_A0.5380.92
170_L173_L0.5370.92
254_A257_V0.5370.92
194_W260_V0.5360.92
190_D193_H0.5350.92
169_F246_G0.5350.92
280_G304_L0.5350.92
163_Y169_F0.5350.92
268_T275_N0.5340.91
94_Q286_L0.5340.91
88_D109_G0.5300.91
245_E248_A0.5290.91
251_L264_L0.5290.91
75_R79_R0.5280.91
53_R87_Y0.5270.91
230_A233_F0.5250.91
104_T107_A0.5250.91
110_V113_G0.5250.91
36_V78_F0.5230.91
9_S96_L0.5220.91
183_F213_I0.5210.90
115_D118_T0.5210.90
280_G303_N0.5210.90
100_A128_Y0.5210.90
255_K274_P0.5200.90
166_A173_L0.5200.90
220_P224_E0.5200.90
93_A147_L0.5170.90
113_G128_Y0.5160.90
171_T174_P0.5160.90
172_N175_T0.5150.90
24_A91_I0.5140.90
13_D192_K0.5130.90
197_E232_G0.5130.90
163_Y170_L0.5120.90
182_V214_K0.5110.90
9_S287_I0.5110.90
168_H171_T0.5100.90
185_H260_V0.5090.89
274_P295_M0.5080.89
58_A74_E0.5080.89
51_V54_V0.5070.89
11_M44_I0.5070.89
21_L51_V0.5070.89
217_W250_V0.5070.89
189_R282_T0.5070.89
204_G232_G0.5050.89
111_K116_W0.5030.89
170_L180_Y0.5030.89
83_Q107_A0.5020.89
81_A84_A0.5000.89
281_P303_N0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.9937 100 0.198 Contact Map
3tovA 1 0.9592 100 0.259 Contact Map
1pswA 1 0.9373 100 0.262 Contact Map
4rapA 3 0.8025 100 0.467 Contact Map
3ot5A 2 0.931 99.4 0.776 Contact Map
4nesA 2 0.9122 99.2 0.798 Contact Map
4rifA 2 0.9248 99.1 0.808 Contact Map
1vgvA 2 0.9373 99 0.816 Contact Map
2yjnA 2 0.9091 99 0.817 Contact Map
3otgA 2 0.931 99 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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