GREMLIN Database
DCP - Peptidyl-dipeptidase dcp
UniProt: P24171 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10212
Length: 681 (655)
Sequences: 3307 (2135)
Seq/√Len: 83.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_E264_R7.6431.00
157_K271_Q6.2171.00
661_R667_A5.5601.00
240_E244_I5.4321.00
280_H283_A4.7331.00
234_R339_F4.5351.00
194_A234_R4.5121.00
151_A154_D4.0891.00
409_A479_L3.7631.00
33_D98_E3.6621.00
192_Q235_D3.6491.00
530_D534_Q3.5121.00
279_P283_A3.4411.00
29_R94_Q3.3081.00
40_R105_D3.3061.00
34_E38_Q3.1931.00
384_E396_R3.0421.00
641_L645_E3.0351.00
190_I201_I2.9901.00
237_A240_E2.9541.00
383_V401_F2.9201.00
129_D132_S2.8701.00
642_R646_A2.8591.00
161_L268_I2.8161.00
117_D121_Q2.7571.00
654_E662_Q2.7561.00
198_E202_A2.7101.00
165_A265_L2.6871.00
186_V218_L2.5901.00
646_A662_Q2.5801.00
645_E649_S2.5681.00
309_R313_S2.5301.00
318_S348_K2.5201.00
175_R258_T2.5031.00
110_G114_A2.4891.00
39_K102_L2.4081.00
654_E659_L2.4031.00
21_D389_P2.3641.00
186_V213_L2.3561.00
516_A530_D2.3501.00
295_E299_N2.3381.00
534_Q538_N2.3221.00
654_E658_R2.2671.00
44_A48_L2.2531.00
157_K160_V2.2511.00
270_A274_T2.2391.00
383_V399_E2.2051.00
375_N381_K2.2021.00
390_V395_V2.1641.00
205_A209_R2.1631.00
260_A264_R2.1611.00
281_Y609_A2.1561.00
234_R343_Q2.1381.00
29_R33_D2.1021.00
364_T368_E2.0931.00
581_L585_N2.0711.00
168_L261_I2.0621.00
110_G155_K2.0471.00
395_V412_Y2.0441.00
38_Q68_L2.0251.00
384_E398_W2.0191.00
278_F287_A2.0141.00
135_L488_L1.9821.00
47_A109_N1.9781.00
631_E664_R1.9481.00
378_F505_N1.9391.00
320_Q331_S1.9331.00
110_G152_Q1.9301.00
192_Q241_K1.9211.00
56_N60_L1.9201.00
132_S485_Y1.9161.00
101_E163_T1.9091.00
462_W510_T1.9041.00
658_R662_Q1.9021.00
24_A27_H1.8921.00
572_D575_D1.8731.00
204_A219_I1.8561.00
185_L241_K1.8551.00
144_V149_K1.8331.00
445_N475_T1.8161.00
176_L601_A1.8141.00
325_K347_E1.8131.00
164_E167_T1.7991.00
456_E523_Q1.7991.00
320_Q324_D1.7981.00
632_Q636_T1.7961.00
34_E37_Q1.7941.00
385_R399_E1.7851.00
272_Q281_Y1.7771.00
156_A160_V1.7761.00
628_W642_R1.7751.00
145_L287_A1.7651.00
19_H22_Q1.7611.00
134_R138_V1.7561.00
364_T520_R1.7531.00
226_Q230_L1.7451.00
636_T639_N1.7411.00
59_I116_V1.7351.00
283_A294_P1.6931.00
117_D140_H1.6831.00
512_P530_D1.6831.00
402_D406_V1.6721.00
311_R314_D1.6591.00
230_L242_L1.6481.00
361_E364_T1.6481.00
35_G72_V1.6351.00
93_E174_Q1.6351.00
317_A321_A1.6281.00
292_K655_D1.6241.00
90_R94_Q1.6141.00
429_N432_E1.6041.00
211_K218_L1.6011.00
280_H563_C1.6011.00
628_W632_Q1.5931.00
500_F625_G1.5791.00
152_Q156_A1.5791.00
579_R583_A1.5771.00
123_R126_L1.5711.00
450_Q464_D1.5701.00
60_L132_S1.5701.00
154_D157_K1.5691.00
129_D484_R1.5671.00
184_G218_L1.5641.00
264_R267_E1.5571.00
428_G444_Y1.5561.00
322_V347_E1.5561.00
397_V410_L1.5481.00
372_W517_R1.5271.00
327_Q340_Y1.5190.99
113_F117_D1.5160.99
209_R214_D1.5130.99
578_L583_A1.5100.99
352_D355_Q1.5100.99
58_T115_R1.5080.99
292_K296_A1.5070.99
308_A548_M1.5060.99
29_R98_E1.5050.99
219_I242_L1.5020.99
169_T265_L1.4970.99
637_R641_L1.4950.99
63_E487_T1.4930.99
133_I137_E1.4920.99
282_A610_A1.4810.99
189_D192_Q1.4760.99
380_I480_F1.4740.99
113_F144_V1.4670.99
650_R654_E1.4590.99
650_R659_L1.4450.99
42_E66_G1.4440.99
47_A111_E1.4380.99
285_K289_Q1.4250.99
122_R126_L1.4230.99
313_S317_A1.4150.99
512_P516_A1.4130.99
223_N227_Q1.4130.99
32_F72_V1.4120.99
624_D666_K1.4000.99
360_F465_V1.4000.99
117_D149_K1.4000.99
131_E484_R1.3980.99
427_M478_G1.3960.99
312_A549_S1.3930.99
583_A587_D1.3840.99
376_Q517_R1.3830.99
187_V238_T1.3820.99
298_L559_M1.3790.99
344_V348_K1.3690.99
299_N303_E1.3630.99
32_F73_T1.3580.99
226_Q242_L1.3470.99
321_A325_K1.3410.99
160_V164_E1.3350.99
207_A218_L1.3320.99
324_D330_F1.3290.99
373_T505_N1.3290.99
302_R585_N1.3270.99
206_E209_R1.3260.99
317_A320_Q1.3150.99
521_H524_S1.3130.98
323_I330_F1.3110.98
37_Q41_A1.3090.98
582_V587_D1.3080.98
536_M539_A1.3020.98
627_Q675_Q1.2980.98
362_L416_F1.2960.98
25_N87_E1.2940.98
23_I27_H1.2840.98
394_D451_K1.2820.98
403_H637_R1.2810.98
262_I597_S1.2790.98
48_L111_E1.2790.98
117_D144_V1.2780.98
246_G249_R1.2650.98
262_I573_V1.2600.98
157_K161_L1.2600.98
374_A472_F1.2590.98
627_Q630_V1.2550.98
293_T296_A1.2480.98
378_F643_F1.2440.98
46_I58_T1.2360.98
113_F140_H1.2360.98
657_E667_A1.2360.98
190_I217_W1.2330.98
581_L587_D1.2320.98
158_L162_N1.2320.98
78_A444_Y1.2320.98
197_S232_E1.2250.98
531_E534_Q1.2240.98
657_E661_R1.2230.98
482_R649_S1.2220.98
120_W123_R1.2200.98
207_A211_K1.2190.98
120_W140_H1.2140.97
283_A295_E1.2080.97
33_D37_Q1.2060.97
140_H144_V1.2050.97
86_D90_R1.2050.97
578_L587_D1.1930.97
561_W597_S1.1900.97
229_A242_L1.1820.97
643_F648_L1.1780.97
27_H31_A1.1770.97
578_L581_L1.1770.97
91_L95_F1.1750.97
105_D159_K1.1740.97
407_G440_H1.1740.97
296_A299_N1.1710.97
372_W376_Q1.1710.97
616_L677_R1.1710.97
162_N272_Q1.1680.97
206_E210_E1.1660.97
344_V542_F1.1660.97
204_A225_T1.1630.97
632_Q639_N1.1620.97
401_F407_G1.1620.97
29_R95_F1.1620.97
298_L563_C1.1560.97
142_R487_T1.1490.96
179_A250_A1.1480.96
145_L284_W1.1480.96
362_L460_L1.1470.96
452_P458_A1.1460.96
658_R661_R1.1460.96
550_E554_A1.1450.96
183_G241_K1.1390.96
219_I225_T1.1340.96
494_P656_L1.1330.96
382_F400_I1.1310.96
578_L582_V1.1310.96
407_G410_L1.1280.96
633_G636_T1.1240.96
626_Y634_G1.1230.96
28_Y79_M1.1220.96
372_W375_N1.1220.96
298_L302_R1.1160.96
171_Q175_R1.1090.96
152_Q155_K1.1050.96
488_L652_N1.1050.96
286_I297_A1.1040.96
236_R333_Q1.1030.96
316_L332_A1.1000.95
660_Y664_R1.0970.95
167_T171_Q1.0950.95
341_A543_N1.0920.95
259_R598_S1.0890.95
402_D408_L1.0880.95
205_A215_N1.0830.95
302_R556_L1.0800.95
139_I487_T1.0760.95
434_S437_N1.0730.95
39_K65_S1.0730.95
80_T88_L1.0720.95
339_F343_Q1.0720.95
368_E372_W1.0710.95
32_F95_F1.0660.95
321_A324_D1.0660.95
316_L320_Q1.0650.95
41_A45_A1.0640.95
381_K401_F1.0620.95
156_A159_K1.0610.95
148_A155_K1.0580.94
323_I332_A1.0560.94
511_H630_V1.0480.94
82_A446_V1.0480.94
135_L485_Y1.0470.94
114_A118_A1.0460.94
528_M533_Q1.0460.94
457_P522_Y1.0430.94
263_Q267_E1.0400.94
80_T92_D1.0390.94
326_Q347_E1.0380.94
226_Q246_G1.0360.94
297_A559_M1.0350.94
44_A109_N1.0330.94
83_H420_S1.0320.94
213_L218_L1.0300.94
42_E46_I1.0290.94
118_A122_R1.0280.94
175_R261_I1.0260.93
114_A117_D1.0260.93
443_I478_G1.0250.93
365_V465_V1.0240.93
657_E668_P1.0220.93
579_R582_V1.0200.93
504_I643_F1.0190.93
366_L396_R1.0180.93
390_V397_V1.0180.93
342_E345_R1.0150.93
511_H626_Y1.0140.93
402_D644_R1.0140.93
430_F444_Y1.0140.93
261_I265_L1.0090.93
122_R125_S1.0080.93
351_L536_M1.0050.93
44_A111_E1.0030.93
33_D36_M1.0020.93
362_L415_F1.0000.93
25_N91_L0.9990.93
229_A233_M0.9980.93
131_E488_L0.9930.92
196_M204_A0.9930.92
646_A654_E0.9920.92
619_Q622_A0.9910.92
158_L272_Q0.9860.92
520_R525_G0.9840.92
190_I198_E0.9830.92
113_F149_K0.9820.92
582_V585_N0.9810.92
390_V412_Y0.9800.92
267_E271_Q0.9790.92
346_R350_D0.9770.92
578_L585_N0.9770.92
399_E407_G0.9770.92
54_D61_A0.9720.91
560_R564_L0.9710.91
366_L413_G0.9690.91
332_A340_Y0.9660.91
184_G213_L0.9650.91
507_H622_A0.9640.91
104_N162_N0.9610.91
669_K672_P0.9580.91
391_Y395_V0.9580.91
530_D533_Q0.9580.91
431_V442_V0.9530.91
260_A263_Q0.9510.91
355_Q358_P0.9490.90
309_R549_S0.9490.90
548_M616_L0.9470.90
79_M83_H0.9410.90
432_E492_N0.9410.90
41_A44_A0.9400.90
40_R44_A0.9370.90
17_A412_Y0.9340.90
580_A583_A0.9300.90
132_S484_R0.9290.90
544_K677_R0.9290.90
44_A47_A0.9260.89
622_A676_H0.9250.89
190_I205_A0.9240.89
376_Q513_Q0.9210.89
294_P559_M0.9210.89
435_T482_R0.9200.89
93_E171_Q0.9190.89
25_N85_N0.9190.89
326_Q343_Q0.9180.89
380_I408_L0.9180.89
429_N492_N0.9170.89
449_Y460_L0.9170.89
43_I62_L0.9150.89
161_L165_A0.9150.89
163_T167_T0.9150.89
291_A297_A0.9140.89
512_P533_Q0.9110.89
638_E642_R0.9100.89
326_Q340_Y0.9090.89
198_E201_I0.9040.88
240_E333_Q0.9020.88
55_F132_S0.9020.88
133_I136_V0.9000.88
488_L653_S0.9000.88
26_H87_E0.8970.88
153_A156_A0.8960.88
494_P655_D0.8930.88
161_L272_Q0.8910.88
107_Y142_R0.8900.87
510_T536_M0.8890.87
130_S654_E0.8870.87
280_H294_P0.8870.87
566_E569_A0.8870.87
269_R562_H0.8860.87
53_P119_V0.8840.87
580_A584_E0.8820.87
516_A527_A0.8820.87
283_A287_A0.8810.87
298_L560_R0.8790.87
303_E307_A0.8780.87
243_F334_P0.8760.87
243_F592_P0.8740.86
459_L522_Y0.8740.86
425_A498_V0.8720.86
515_F533_Q0.8720.86
188_N217_W0.8710.86
265_L604_F0.8710.86
53_P115_R0.8710.86
183_G242_L0.8700.86
251_E259_R0.8670.86
125_S137_E0.8670.86
11_S19_H0.8640.86
343_Q346_R0.8630.86
463_D466_I0.8630.86
129_D485_Y0.8580.85
425_A467_T0.8580.85
623_D676_H0.8550.85
27_H30_P0.8550.85
646_A659_L0.8520.85
370_V468_L0.8520.85
204_A229_A0.8510.85
35_G68_L0.8490.85
25_N88_L0.8490.85
529_P532_L0.8480.85
659_L662_Q0.8480.85
43_I106_I0.8460.85
125_S133_I0.8450.85
127_G133_I0.8450.85
304_I552_L0.8440.85
185_L229_A0.8440.85
187_V235_D0.8430.84
29_R91_L0.8410.84
223_N246_G0.8400.84
33_D94_Q0.8390.84
32_F36_M0.8380.84
401_F405_G0.8380.84
579_R585_N0.8380.84
196_M233_M0.8380.84
303_E670_I0.8360.84
229_A238_T0.8360.84
646_A650_R0.8350.84
89_Q178_A0.8320.84
455_G523_Q0.8320.84
574_D580_A0.8300.84
548_M677_R0.8300.84
504_I508_W0.8300.84
181_K222_L0.8290.83
624_D664_R0.8290.83
33_D95_F0.8270.83
366_L468_L0.8260.83
631_E666_K0.8230.83
94_Q98_E0.8210.83
298_L556_L0.8210.83
478_G491_T0.8210.83
236_R335_W0.8200.83
141_Q288_D0.8190.83
207_A210_E0.8170.83
87_E90_R0.8150.82
134_R652_N0.8140.82
173_N601_A0.8140.82
411_F479_L0.8140.82
58_T61_A0.8130.82
235_D241_K0.8110.82
119_V136_V0.8100.82
297_A301_M0.8090.82
359_Y532_L0.8080.82
391_Y430_F0.8070.82
310_Q313_S0.8050.82
314_D317_A0.8050.82
233_M238_T0.8010.81
323_I328_G0.8010.81
516_A533_Q0.7990.81
266_V561_W0.7980.81
382_F411_F0.7980.81
399_E410_L0.7970.81
145_L278_F0.7970.81
60_L64_Q0.7950.81
54_D57_N0.7940.81
347_E350_D0.7940.81
194_A235_D0.7930.81
556_L586_M0.7920.81
311_R545_G0.7900.80
80_T84_T0.7890.80
123_R133_I0.7890.80
53_P118_A0.7880.80
435_T484_R0.7880.80
375_N380_I0.7880.80
551_L616_L0.7870.80
46_I65_S0.7870.80
161_L271_Q0.7860.80
644_R649_S0.7860.80
608_Y615_Y0.7860.80
28_Y76_F0.7860.80
181_K420_S0.7830.80
504_I625_G0.7830.80
272_Q284_W0.7820.80
660_Y668_P0.7820.80
108_L159_K0.7810.80
40_R102_L0.7810.80
24_A30_P0.7800.80
507_H676_H0.7800.80
507_H626_Y0.7800.80
346_R352_D0.7800.80
171_Q174_Q0.7780.79
125_S136_V0.7770.79
544_K548_M0.7770.79
211_K419_D0.7770.79
385_R388_I0.7760.79
192_Q237_A0.7750.79
46_I61_A0.7730.79
184_G211_K0.7730.79
243_F247_W0.7730.79
350_D535_K0.7720.79
374_A382_F0.7670.78
574_D597_S0.7630.78
240_E335_W0.7630.78
279_P295_E0.7610.78
189_D217_W0.7610.78
59_I136_V0.7610.78
316_L337_W0.7600.78
126_L136_V0.7600.78
671_M675_Q0.7600.78
141_Q287_A0.7590.78
655_D658_R0.7590.78
187_V229_A0.7540.77
373_T514_V0.7540.77
470_H499_E0.7540.77
579_R587_D0.7540.77
520_R527_A0.7540.77
408_L479_L0.7530.77
55_F59_I0.7530.77
187_V193_L0.7520.77
349_F539_A0.7520.77
111_E114_A0.7510.77
411_F445_N0.7510.77
40_R98_E0.7510.77
602_H612_Y0.7500.77
134_R137_E0.7500.77
196_M229_A0.7490.77
363_N396_R0.7470.77
42_E65_S0.7460.76
120_W137_E0.7460.76
73_T77_F0.7460.76
124_E133_I0.7460.76
311_R679_L0.7450.76
360_F462_W0.7450.76
666_K669_K0.7430.76
375_N382_F0.7430.76
320_Q332_A0.7430.76
138_V141_Q0.7410.76
208_A218_L0.7400.76
23_I31_A0.7400.76
199_Q354_A0.7390.76
179_A252_K0.7380.76
299_N302_R0.7380.76
85_N420_S0.7380.76
197_S200_E0.7370.76
270_A566_E0.7350.75
355_Q532_L0.7340.75
427_M443_I0.7330.75
164_E260_A0.7320.75
344_V349_F0.7310.75
583_A586_M0.7310.75
82_A391_Y0.7270.75
582_V586_M0.7270.75
28_Y88_L0.7270.75
17_A410_L0.7260.75
632_Q638_E0.7260.75
187_V217_W0.7260.75
322_V344_V0.7250.74
63_E486_A0.7240.74
379_G402_D0.7240.74
171_Q261_I0.7230.74
628_W631_E0.7220.74
374_A476_L0.7220.74
38_Q41_A0.7200.74
134_R655_D0.7190.74
490_G498_V0.7180.74
551_L554_A0.7180.74
628_W664_R0.7170.74
388_I397_V0.7160.73
528_M532_L0.7160.73
113_F120_W0.7140.73
314_D318_S0.7140.73
650_R653_S0.7130.73
78_A430_F0.7130.73
628_W636_T0.7130.73
236_R336_D0.7120.73
560_R585_N0.7100.73
416_F458_A0.7090.73
461_L464_D0.7090.73
137_E141_Q0.7080.73
123_R137_E0.7080.73
332_A337_W0.7060.72
552_L616_L0.7060.72
374_A400_I0.7050.72
638_E645_E0.7050.72
83_H88_L0.7050.72
313_S320_Q0.7030.72
384_E387_D0.7030.72
188_N192_Q0.7020.72
519_A528_M0.7010.72
511_H634_G0.7010.72
602_H615_Y0.7000.72
385_R397_V0.7000.72
281_Y285_K0.7000.72
196_M200_E0.6990.72
531_E535_K0.6990.72
315_E543_N0.6970.71
231_A545_G0.6960.71
78_A82_A0.6960.71
471_E474_H0.6960.71
600_F612_Y0.6950.71
85_N88_L0.6950.71
95_F98_E0.6940.71
601_A605_G0.6930.71
165_A268_I0.6930.71
200_E229_A0.6920.71
32_F91_L0.6920.71
209_R454_A0.6910.71
274_T279_P0.6900.71
398_W413_G0.6900.71
270_A565_E0.6890.71
61_A136_V0.6880.70
55_F61_A0.6860.70
155_K654_E0.6850.70
274_T566_E0.6840.70
560_R581_L0.6820.70
84_T89_Q0.6800.70
167_T264_R0.6800.70
139_I142_R0.6770.69
160_V163_T0.6770.69
270_A564_L0.6770.69
345_R542_F0.6740.69
194_A339_F0.6730.69
154_D274_T0.6720.69
385_R410_L0.6720.69
404_N644_R0.6710.69
301_M556_L0.6710.69
110_G151_A0.6700.68
416_F452_P0.6700.68
534_Q537_R0.6690.68
324_D329_G0.6680.68
459_L521_H0.6660.68
632_Q642_R0.6650.68
203_L451_K0.6640.68
101_E105_D0.6630.68
645_E650_R0.6630.68
36_M102_L0.6620.68
43_I109_N0.6620.68
415_F468_L0.6620.68
373_T469_F0.6590.67
361_E520_R0.6590.67
123_R127_G0.6580.67
470_H615_Y0.6580.67
507_H623_D0.6570.67
569_A572_D0.6570.67
320_Q330_F0.6570.67
560_R582_V0.6540.67
552_L556_L0.6540.67
483_Q653_S0.6530.67
334_P591_I0.6520.66
546_Y549_S0.6510.66
39_K106_I0.6480.66
208_A212_G0.6470.66
51_Q57_N0.6470.66
432_E489_S0.6460.66
549_S552_L0.6460.66
431_V439_T0.6460.66
620_M668_P0.6450.66
77_F99_L0.6450.66
581_L584_E0.6450.66
553_S583_A0.6440.65
360_F528_M0.6440.65
116_V139_I0.6440.65
381_K405_G0.6440.65
324_D328_G0.6440.65
258_T261_I0.6420.65
449_Y458_A0.6400.65
323_I327_Q0.6390.65
470_H474_H0.6390.65
600_F603_I0.6390.65
286_I291_A0.6380.65
96_S100_A0.6380.65
36_M99_L0.6380.65
403_H641_L0.6380.65
477_H501_P0.6380.65
306_P313_S0.6370.65
227_Q338_A0.6360.64
36_M40_R0.6360.64
491_T498_V0.6340.64
319_I332_A0.6330.64
322_V326_Q0.6330.64
243_F335_W0.6330.64
84_T420_S0.6320.64
561_W603_I0.6320.64
78_A428_G0.6320.64
316_L589_P0.6320.64
278_F284_W0.6310.64
565_E568_E0.6300.64
78_A391_Y0.6290.64
194_A343_Q0.6290.64
626_Y647_I0.6290.64
274_T280_H0.6290.64
67_E71_R0.6280.63
428_G446_V0.6270.63
546_Y588_L0.6250.63
160_V271_Q0.6250.63
557_L561_W0.6240.63
318_S344_V0.6240.63
413_G445_N0.6220.63
119_V126_L0.6210.63
508_W634_G0.6190.62
443_I491_T0.6190.62
36_M39_K0.6190.62
208_A213_L0.6190.62
526_A531_E0.6180.62
580_A597_S0.6180.62
410_L440_H0.6180.62
546_Y550_E0.6170.62
130_S133_I0.6170.62
471_E506_E0.6160.62
35_G39_K0.6150.62
358_P523_Q0.6150.62
64_Q434_S0.6140.62
98_E101_E0.6140.62
391_Y446_V0.6140.62
294_P563_C0.6140.62
638_E641_L0.6140.62
500_F504_I0.6130.62
283_A563_C0.6130.62
418_R421_K0.6130.62
467_T602_H0.6130.62
643_F647_I0.6120.62
381_K402_D0.6110.61
548_M555_A0.6110.61
608_Y612_Y0.6110.61
105_D109_N0.6100.61
580_A589_P0.6090.61
90_R93_E0.6080.61
578_L586_M0.6080.61
601_A614_A0.6070.61
179_A183_G0.6070.61
422_S426_W0.6060.61
209_R212_G0.6060.61
366_L382_F0.6050.61
242_L246_G0.6040.60
94_Q97_A0.6040.60
30_P41_A0.6030.60
63_E66_G0.6030.60
474_H499_E0.6020.60
20_F23_I0.6020.60
102_L105_D0.6010.60
116_V140_H0.6010.60
471_E499_E0.6010.60
53_P58_T0.6010.60
185_L238_T0.6010.60
187_V219_I0.6000.60
307_A670_I0.5990.60
289_Q618_T0.5990.60
399_E409_A0.5980.60
37_Q40_R0.5980.60
491_T495_R0.5970.60
322_V543_N0.5970.60
634_G639_N0.5960.59
368_E375_N0.5960.59
420_S559_M0.5950.59
151_A155_K0.5940.59
23_I75_V0.5940.59
188_N214_D0.5940.59
302_R306_P0.5940.59
500_F505_N0.5930.59
92_D170_S0.5930.59
625_G660_Y0.5910.59
310_Q314_D0.5910.59
432_E486_A0.5900.59
324_D331_S0.5890.59
195_G233_M0.5880.58
84_T92_D0.5870.58
200_E228_P0.5870.58
575_D581_L0.5870.58
508_W626_Y0.5870.58
477_H493_T0.5850.58
191_A201_I0.5850.58
285_K609_A0.5840.58
30_P33_D0.5830.58
42_E45_A0.5830.58
208_A217_W0.5830.58
466_I509_A0.5830.58
356_L532_L0.5820.58
36_M98_E0.5820.58
112_L143_F0.5820.58
53_P57_N0.5800.57
60_L135_L0.5780.57
413_G475_T0.5770.57
316_L588_L0.5760.57
265_L609_A0.5760.57
584_E589_P0.5730.57
187_V192_Q0.5720.56
429_N489_S0.5720.56
203_L207_A0.5720.56
379_G403_H0.5720.56
81_A428_G0.5720.56
508_W635_L0.5710.56
196_M219_I0.5710.56
612_Y615_Y0.5710.56
345_R353_E0.5700.56
532_L536_M0.5700.56
57_N115_R0.5680.56
427_M491_T0.5680.56
193_L201_I0.5680.56
75_V79_M0.5670.56
302_R560_R0.5670.56
290_M500_F0.5670.56
296_A300_F0.5670.56
544_K547_E0.5660.56
482_R645_E0.5660.56
320_Q323_I0.5660.56
470_H506_E0.5660.56
80_T89_Q0.5660.56
211_K220_P0.5650.55
39_K42_E0.5650.55
62_L139_I0.5650.55
301_M552_L0.5650.55
145_L288_D0.5640.55
642_R662_Q0.5630.55
508_W629_F0.5630.55
602_H608_Y0.5630.55
70_T432_E0.5630.55
52_M122_R0.5620.55
326_Q339_F0.5620.55
24_A87_E0.5610.55
474_H506_E0.5610.55
303_E306_P0.5600.55
35_G65_S0.5600.55
103_A107_Y0.5600.55
271_Q274_T0.5590.55
49_N53_P0.5590.55
279_P565_E0.5580.55
616_L625_G0.5580.55
666_K672_P0.5570.54
144_V287_A0.5570.54
338_A341_A0.5560.54
358_P522_Y0.5560.54
138_V487_T0.5560.54
378_F648_L0.5550.54
356_L528_M0.5550.54
427_M498_V0.5550.54
70_T429_N0.5540.54
308_A649_S0.5540.54
238_T241_K0.5540.54
315_E545_G0.5520.54
121_Q531_E0.5520.54
408_L644_R0.5520.54
173_N605_G0.5510.54
262_I266_V0.5510.54
232_E246_G0.5510.54
232_E346_R0.5500.53
164_E268_I0.5500.53
495_R498_V0.5500.53
39_K43_I0.5500.53
301_M555_A0.5490.53
228_P231_A0.5490.53
533_Q537_R0.5490.53
548_M673_M0.5490.53
304_I670_I0.5490.53
74_S486_A0.5480.53
236_R240_E0.5480.53
299_N393_P0.5470.53
537_R540_S0.5460.53
499_E615_Y0.5460.53
579_R586_M0.5450.53
263_Q573_V0.5450.53
623_D673_M0.5450.53
308_A549_S0.5450.53
306_P310_Q0.5440.53
278_F283_A0.5440.53
499_E502_S0.5430.53
603_I609_A0.5430.53
321_A347_E0.5420.52
366_L370_V0.5420.52
120_W133_I0.5420.52
600_F608_Y0.5410.52
411_F475_T0.5410.52
581_L586_M0.5400.52
72_V99_L0.5390.52
237_A241_K0.5390.52
495_R614_A0.5380.52
116_V119_V0.5380.52
545_G548_M0.5380.52
327_Q330_F0.5380.52
462_W536_M0.5370.52
349_F535_K0.5370.52
427_M490_G0.5370.52
64_Q486_A0.5370.52
187_V190_I0.5370.52
45_A191_A0.5360.52
499_E506_E0.5360.52
62_L106_I0.5360.52
628_W639_N0.5360.52
621_L660_Y0.5350.52
185_L235_D0.5350.52
199_Q357_K0.5340.51
422_S614_A0.5330.51
565_E569_A0.5330.51
289_Q495_R0.5320.51
375_N403_H0.5320.51
636_T642_R0.5310.51
622_A675_Q0.5310.51
368_E520_R0.5310.51
74_S492_N0.5290.51
543_N546_Y0.5290.51
59_I119_V0.5290.51
55_F58_T0.5290.51
55_F485_Y0.5280.51
312_A652_N0.5280.51
304_I616_L0.5280.51
417_A424_G0.5280.51
319_I344_V0.5270.50
325_K328_G0.5260.50
236_R323_I0.5260.50
305_V549_S0.5250.50
386_F389_P0.5250.50
635_L640_G0.5240.50
624_D660_Y0.5230.50
170_S174_Q0.5230.50
502_S602_H0.5220.50
104_N159_K0.5220.50
655_D659_L0.5210.50
27_H72_V0.5210.50
291_A617_W0.5210.50
23_I30_P0.5210.50
449_Y468_L0.5200.50
448_N465_V0.5200.50
370_V374_A0.5200.50
290_M416_F0.5190.49
483_Q489_S0.5190.49
318_S321_A0.5190.49
39_K46_I0.5180.49
121_Q522_Y0.5180.49
185_L188_N0.5170.49
202_A206_E0.5170.49
349_F536_M0.5170.49
19_H389_P0.5170.49
221_L245_A0.5160.49
226_Q258_T0.5160.49
498_V607_G0.5150.49
131_E483_Q0.5150.49
548_M551_L0.5150.49
388_I391_Y0.5120.48
443_I479_L0.5120.48
45_A61_A0.5110.48
470_H502_S0.5110.48
373_T635_L0.5100.48
204_A207_A0.5100.48
457_P521_H0.5100.48
48_L154_D0.5100.48
401_F440_H0.5100.48
81_A422_S0.5090.48
444_Y447_C0.5080.48
31_A72_V0.5080.48
138_V488_L0.5070.48
76_F91_L0.5070.48
67_E70_T0.5070.48
189_D235_D0.5060.48
510_T540_S0.5060.48
122_R133_I0.5060.48
191_A393_P0.5060.48
381_K406_V0.5050.48
381_K403_H0.5050.48
321_A348_K0.5050.48
195_G234_R0.5040.47
180_N249_R0.5040.47
514_V517_R0.5040.47
644_R648_L0.5030.47
186_V214_D0.5030.47
409_A440_H0.5030.47
266_V564_L0.5020.47
17_A442_V0.5020.47
158_L276_L0.5010.47
17_A389_P0.5010.47
557_L597_S0.5010.47
447_C458_A0.5010.47
248_T252_K0.5000.47
396_R468_L0.5000.47
557_L579_R0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y791 1 0.9956 100 0.215 Contact Map
4ka7A 1 0.9853 100 0.22 Contact Map
2o3eA 1 0.9589 100 0.224 Contact Map
2o36A 1 0.9427 100 0.268 Contact Map
1r42A 1 0.7753 100 0.586 Contact Map
4ca6A 1 0.7885 100 0.592 Contact Map
4c2oA 1 0.7621 100 0.606 Contact Map
3sksA 1 0.7665 100 0.61 Contact Map
3ahnA 1 0.7827 100 0.616 Contact Map
2qr4A 2 0.721 100 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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