DCP - ECOLI - GREMLIN Contacts

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DCP - Peptidyl-dipeptidase dcp

UniProt:	P24171	Sequences: MTTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQMPDFNNTILALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFMREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRGLNI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10212
Length:	681 (655)
Sequences:	3307 (2135)
Seq/√Len:	83.4

ECOLI - DCP OPDA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_E	264_R	7.643	1.00
157_K	271_Q	6.217	1.00
661_R	667_A	5.560	1.00
240_E	244_I	5.432	1.00
280_H	283_A	4.733	1.00
234_R	339_F	4.535	1.00
194_A	234_R	4.512	1.00
151_A	154_D	4.089	1.00
409_A	479_L	3.763	1.00
33_D	98_E	3.662	1.00
192_Q	235_D	3.649	1.00
530_D	534_Q	3.512	1.00
279_P	283_A	3.441	1.00
29_R	94_Q	3.308	1.00
40_R	105_D	3.306	1.00
34_E	38_Q	3.193	1.00
384_E	396_R	3.042	1.00
641_L	645_E	3.035	1.00
190_I	201_I	2.990	1.00
237_A	240_E	2.954	1.00
383_V	401_F	2.920	1.00
129_D	132_S	2.870	1.00
642_R	646_A	2.859	1.00
161_L	268_I	2.816	1.00
117_D	121_Q	2.757	1.00
654_E	662_Q	2.756	1.00
198_E	202_A	2.710	1.00
165_A	265_L	2.687	1.00
186_V	218_L	2.590	1.00
646_A	662_Q	2.580	1.00
645_E	649_S	2.568	1.00
309_R	313_S	2.530	1.00
318_S	348_K	2.520	1.00
175_R	258_T	2.503	1.00
110_G	114_A	2.489	1.00
39_K	102_L	2.408	1.00
654_E	659_L	2.403	1.00
21_D	389_P	2.364	1.00
186_V	213_L	2.356	1.00
516_A	530_D	2.350	1.00
295_E	299_N	2.338	1.00
534_Q	538_N	2.322	1.00
654_E	658_R	2.267	1.00
44_A	48_L	2.253	1.00
157_K	160_V	2.251	1.00
270_A	274_T	2.239	1.00
383_V	399_E	2.205	1.00
375_N	381_K	2.202	1.00
390_V	395_V	2.164	1.00
205_A	209_R	2.163	1.00
260_A	264_R	2.161	1.00
281_Y	609_A	2.156	1.00
234_R	343_Q	2.138	1.00
29_R	33_D	2.102	1.00
364_T	368_E	2.093	1.00
581_L	585_N	2.071	1.00
168_L	261_I	2.062	1.00
110_G	155_K	2.047	1.00
395_V	412_Y	2.044	1.00
38_Q	68_L	2.025	1.00
384_E	398_W	2.019	1.00
278_F	287_A	2.014	1.00
135_L	488_L	1.982	1.00
47_A	109_N	1.978	1.00
631_E	664_R	1.948	1.00
378_F	505_N	1.939	1.00
320_Q	331_S	1.933	1.00
110_G	152_Q	1.930	1.00
192_Q	241_K	1.921	1.00
56_N	60_L	1.920	1.00
132_S	485_Y	1.916	1.00
101_E	163_T	1.909	1.00
462_W	510_T	1.904	1.00
658_R	662_Q	1.902	1.00
24_A	27_H	1.892	1.00
572_D	575_D	1.873	1.00
204_A	219_I	1.856	1.00
185_L	241_K	1.855	1.00
144_V	149_K	1.833	1.00
445_N	475_T	1.816	1.00
176_L	601_A	1.814	1.00
325_K	347_E	1.813	1.00
164_E	167_T	1.799	1.00
456_E	523_Q	1.799	1.00
320_Q	324_D	1.798	1.00
632_Q	636_T	1.796	1.00
34_E	37_Q	1.794	1.00
385_R	399_E	1.785	1.00
272_Q	281_Y	1.777	1.00
156_A	160_V	1.776	1.00
628_W	642_R	1.775	1.00
145_L	287_A	1.765	1.00
19_H	22_Q	1.761	1.00
134_R	138_V	1.756	1.00
364_T	520_R	1.753	1.00
226_Q	230_L	1.745	1.00
636_T	639_N	1.741	1.00
59_I	116_V	1.735	1.00
283_A	294_P	1.693	1.00
117_D	140_H	1.683	1.00
512_P	530_D	1.683	1.00
402_D	406_V	1.672	1.00
311_R	314_D	1.659	1.00
230_L	242_L	1.648	1.00
361_E	364_T	1.648	1.00
35_G	72_V	1.635	1.00
93_E	174_Q	1.635	1.00
317_A	321_A	1.628	1.00
292_K	655_D	1.624	1.00
90_R	94_Q	1.614	1.00
429_N	432_E	1.604	1.00
211_K	218_L	1.601	1.00
280_H	563_C	1.601	1.00
628_W	632_Q	1.593	1.00
500_F	625_G	1.579	1.00
152_Q	156_A	1.579	1.00
579_R	583_A	1.577	1.00
123_R	126_L	1.571	1.00
450_Q	464_D	1.570	1.00
60_L	132_S	1.570	1.00
154_D	157_K	1.569	1.00
129_D	484_R	1.567	1.00
184_G	218_L	1.564	1.00
264_R	267_E	1.557	1.00
428_G	444_Y	1.556	1.00
322_V	347_E	1.556	1.00
397_V	410_L	1.548	1.00
372_W	517_R	1.527	1.00
327_Q	340_Y	1.519	0.99
113_F	117_D	1.516	0.99
209_R	214_D	1.513	0.99
578_L	583_A	1.510	0.99
352_D	355_Q	1.510	0.99
58_T	115_R	1.508	0.99
292_K	296_A	1.507	0.99
308_A	548_M	1.506	0.99
29_R	98_E	1.505	0.99
219_I	242_L	1.502	0.99
169_T	265_L	1.497	0.99
637_R	641_L	1.495	0.99
63_E	487_T	1.493	0.99
133_I	137_E	1.492	0.99
282_A	610_A	1.481	0.99
189_D	192_Q	1.476	0.99
380_I	480_F	1.474	0.99
113_F	144_V	1.467	0.99
650_R	654_E	1.459	0.99
650_R	659_L	1.445	0.99
42_E	66_G	1.444	0.99
47_A	111_E	1.438	0.99
285_K	289_Q	1.425	0.99
122_R	126_L	1.423	0.99
313_S	317_A	1.415	0.99
512_P	516_A	1.413	0.99
223_N	227_Q	1.413	0.99
32_F	72_V	1.412	0.99
624_D	666_K	1.400	0.99
360_F	465_V	1.400	0.99
117_D	149_K	1.400	0.99
131_E	484_R	1.398	0.99
427_M	478_G	1.396	0.99
312_A	549_S	1.393	0.99
583_A	587_D	1.384	0.99
376_Q	517_R	1.383	0.99
187_V	238_T	1.382	0.99
298_L	559_M	1.379	0.99
344_V	348_K	1.369	0.99
299_N	303_E	1.363	0.99
32_F	73_T	1.358	0.99
226_Q	242_L	1.347	0.99
321_A	325_K	1.341	0.99
160_V	164_E	1.335	0.99
207_A	218_L	1.332	0.99
324_D	330_F	1.329	0.99
373_T	505_N	1.329	0.99
302_R	585_N	1.327	0.99
206_E	209_R	1.326	0.99
317_A	320_Q	1.315	0.99
521_H	524_S	1.313	0.98
323_I	330_F	1.311	0.98
37_Q	41_A	1.309	0.98
582_V	587_D	1.308	0.98
536_M	539_A	1.302	0.98
627_Q	675_Q	1.298	0.98
362_L	416_F	1.296	0.98
25_N	87_E	1.294	0.98
23_I	27_H	1.284	0.98
394_D	451_K	1.282	0.98
403_H	637_R	1.281	0.98
262_I	597_S	1.279	0.98
48_L	111_E	1.279	0.98
117_D	144_V	1.278	0.98
246_G	249_R	1.265	0.98
262_I	573_V	1.260	0.98
157_K	161_L	1.260	0.98
374_A	472_F	1.259	0.98
627_Q	630_V	1.255	0.98
293_T	296_A	1.248	0.98
378_F	643_F	1.244	0.98
46_I	58_T	1.236	0.98
113_F	140_H	1.236	0.98
657_E	667_A	1.236	0.98
190_I	217_W	1.233	0.98
581_L	587_D	1.232	0.98
158_L	162_N	1.232	0.98
78_A	444_Y	1.232	0.98
197_S	232_E	1.225	0.98
531_E	534_Q	1.224	0.98
657_E	661_R	1.223	0.98
482_R	649_S	1.222	0.98
120_W	123_R	1.220	0.98
207_A	211_K	1.219	0.98
120_W	140_H	1.214	0.97
283_A	295_E	1.208	0.97
33_D	37_Q	1.206	0.97
140_H	144_V	1.205	0.97
86_D	90_R	1.205	0.97
578_L	587_D	1.193	0.97
561_W	597_S	1.190	0.97
229_A	242_L	1.182	0.97
643_F	648_L	1.178	0.97
27_H	31_A	1.177	0.97
578_L	581_L	1.177	0.97
91_L	95_F	1.175	0.97
105_D	159_K	1.174	0.97
407_G	440_H	1.174	0.97
296_A	299_N	1.171	0.97
372_W	376_Q	1.171	0.97
616_L	677_R	1.171	0.97
162_N	272_Q	1.168	0.97
206_E	210_E	1.166	0.97
344_V	542_F	1.166	0.97
204_A	225_T	1.163	0.97
632_Q	639_N	1.162	0.97
401_F	407_G	1.162	0.97
29_R	95_F	1.162	0.97
298_L	563_C	1.156	0.97
142_R	487_T	1.149	0.96
179_A	250_A	1.148	0.96
145_L	284_W	1.148	0.96
362_L	460_L	1.147	0.96
452_P	458_A	1.146	0.96
658_R	661_R	1.146	0.96
550_E	554_A	1.145	0.96
183_G	241_K	1.139	0.96
219_I	225_T	1.134	0.96
494_P	656_L	1.133	0.96
382_F	400_I	1.131	0.96
578_L	582_V	1.131	0.96
407_G	410_L	1.128	0.96
633_G	636_T	1.124	0.96
626_Y	634_G	1.123	0.96
28_Y	79_M	1.122	0.96
372_W	375_N	1.122	0.96
298_L	302_R	1.116	0.96
171_Q	175_R	1.109	0.96
152_Q	155_K	1.105	0.96
488_L	652_N	1.105	0.96
286_I	297_A	1.104	0.96
236_R	333_Q	1.103	0.96
316_L	332_A	1.100	0.95
660_Y	664_R	1.097	0.95
167_T	171_Q	1.095	0.95
341_A	543_N	1.092	0.95
259_R	598_S	1.089	0.95
402_D	408_L	1.088	0.95
205_A	215_N	1.083	0.95
302_R	556_L	1.080	0.95
139_I	487_T	1.076	0.95
434_S	437_N	1.073	0.95
39_K	65_S	1.073	0.95
80_T	88_L	1.072	0.95
339_F	343_Q	1.072	0.95
368_E	372_W	1.071	0.95
32_F	95_F	1.066	0.95
321_A	324_D	1.066	0.95
316_L	320_Q	1.065	0.95
41_A	45_A	1.064	0.95
381_K	401_F	1.062	0.95
156_A	159_K	1.061	0.95
148_A	155_K	1.058	0.94
323_I	332_A	1.056	0.94
511_H	630_V	1.048	0.94
82_A	446_V	1.048	0.94
135_L	485_Y	1.047	0.94
114_A	118_A	1.046	0.94
528_M	533_Q	1.046	0.94
457_P	522_Y	1.043	0.94
263_Q	267_E	1.040	0.94
80_T	92_D	1.039	0.94
326_Q	347_E	1.038	0.94
226_Q	246_G	1.036	0.94
297_A	559_M	1.035	0.94
44_A	109_N	1.033	0.94
83_H	420_S	1.032	0.94
213_L	218_L	1.030	0.94
42_E	46_I	1.029	0.94
118_A	122_R	1.028	0.94
175_R	261_I	1.026	0.93
114_A	117_D	1.026	0.93
443_I	478_G	1.025	0.93
365_V	465_V	1.024	0.93
657_E	668_P	1.022	0.93
579_R	582_V	1.020	0.93
504_I	643_F	1.019	0.93
366_L	396_R	1.018	0.93
390_V	397_V	1.018	0.93
342_E	345_R	1.015	0.93
511_H	626_Y	1.014	0.93
402_D	644_R	1.014	0.93
430_F	444_Y	1.014	0.93
261_I	265_L	1.009	0.93
122_R	125_S	1.008	0.93
351_L	536_M	1.005	0.93
44_A	111_E	1.003	0.93
33_D	36_M	1.002	0.93
362_L	415_F	1.000	0.93
25_N	91_L	0.999	0.93
229_A	233_M	0.998	0.93
131_E	488_L	0.993	0.92
196_M	204_A	0.993	0.92
646_A	654_E	0.992	0.92
619_Q	622_A	0.991	0.92
158_L	272_Q	0.986	0.92
520_R	525_G	0.984	0.92
190_I	198_E	0.983	0.92
113_F	149_K	0.982	0.92
582_V	585_N	0.981	0.92
390_V	412_Y	0.980	0.92
267_E	271_Q	0.979	0.92
346_R	350_D	0.977	0.92
578_L	585_N	0.977	0.92
399_E	407_G	0.977	0.92
54_D	61_A	0.972	0.91
560_R	564_L	0.971	0.91
366_L	413_G	0.969	0.91
332_A	340_Y	0.966	0.91
184_G	213_L	0.965	0.91
507_H	622_A	0.964	0.91
104_N	162_N	0.961	0.91
669_K	672_P	0.958	0.91
391_Y	395_V	0.958	0.91
530_D	533_Q	0.958	0.91
431_V	442_V	0.953	0.91
260_A	263_Q	0.951	0.91
355_Q	358_P	0.949	0.90
309_R	549_S	0.949	0.90
548_M	616_L	0.947	0.90
79_M	83_H	0.941	0.90
432_E	492_N	0.941	0.90
41_A	44_A	0.940	0.90
40_R	44_A	0.937	0.90
17_A	412_Y	0.934	0.90
580_A	583_A	0.930	0.90
132_S	484_R	0.929	0.90
544_K	677_R	0.929	0.90
44_A	47_A	0.926	0.89
622_A	676_H	0.925	0.89
190_I	205_A	0.924	0.89
376_Q	513_Q	0.921	0.89
294_P	559_M	0.921	0.89
435_T	482_R	0.920	0.89
93_E	171_Q	0.919	0.89
25_N	85_N	0.919	0.89
326_Q	343_Q	0.918	0.89
380_I	408_L	0.918	0.89
429_N	492_N	0.917	0.89
449_Y	460_L	0.917	0.89
43_I	62_L	0.915	0.89
161_L	165_A	0.915	0.89
163_T	167_T	0.915	0.89
291_A	297_A	0.914	0.89
512_P	533_Q	0.911	0.89
638_E	642_R	0.910	0.89
326_Q	340_Y	0.909	0.89
198_E	201_I	0.904	0.88
240_E	333_Q	0.902	0.88
55_F	132_S	0.902	0.88
133_I	136_V	0.900	0.88
488_L	653_S	0.900	0.88
26_H	87_E	0.897	0.88
153_A	156_A	0.896	0.88
494_P	655_D	0.893	0.88
161_L	272_Q	0.891	0.88
107_Y	142_R	0.890	0.87
510_T	536_M	0.889	0.87
130_S	654_E	0.887	0.87
280_H	294_P	0.887	0.87
566_E	569_A	0.887	0.87
269_R	562_H	0.886	0.87
53_P	119_V	0.884	0.87
580_A	584_E	0.882	0.87
516_A	527_A	0.882	0.87
283_A	287_A	0.881	0.87
298_L	560_R	0.879	0.87
303_E	307_A	0.878	0.87
243_F	334_P	0.876	0.87
243_F	592_P	0.874	0.86
459_L	522_Y	0.874	0.86
425_A	498_V	0.872	0.86
515_F	533_Q	0.872	0.86
188_N	217_W	0.871	0.86
265_L	604_F	0.871	0.86
53_P	115_R	0.871	0.86
183_G	242_L	0.870	0.86
251_E	259_R	0.867	0.86
125_S	137_E	0.867	0.86
11_S	19_H	0.864	0.86
343_Q	346_R	0.863	0.86
463_D	466_I	0.863	0.86
129_D	485_Y	0.858	0.85
425_A	467_T	0.858	0.85
623_D	676_H	0.855	0.85
27_H	30_P	0.855	0.85
646_A	659_L	0.852	0.85
370_V	468_L	0.852	0.85
204_A	229_A	0.851	0.85
35_G	68_L	0.849	0.85
25_N	88_L	0.849	0.85
529_P	532_L	0.848	0.85
659_L	662_Q	0.848	0.85
43_I	106_I	0.846	0.85
125_S	133_I	0.845	0.85
127_G	133_I	0.845	0.85
304_I	552_L	0.844	0.85
185_L	229_A	0.844	0.85
187_V	235_D	0.843	0.84
29_R	91_L	0.841	0.84
223_N	246_G	0.840	0.84
33_D	94_Q	0.839	0.84
32_F	36_M	0.838	0.84
401_F	405_G	0.838	0.84
579_R	585_N	0.838	0.84
196_M	233_M	0.838	0.84
303_E	670_I	0.836	0.84
229_A	238_T	0.836	0.84
646_A	650_R	0.835	0.84
89_Q	178_A	0.832	0.84
455_G	523_Q	0.832	0.84
574_D	580_A	0.830	0.84
548_M	677_R	0.830	0.84
504_I	508_W	0.830	0.84
181_K	222_L	0.829	0.83
624_D	664_R	0.829	0.83
33_D	95_F	0.827	0.83
366_L	468_L	0.826	0.83
631_E	666_K	0.823	0.83
94_Q	98_E	0.821	0.83
298_L	556_L	0.821	0.83
478_G	491_T	0.821	0.83
236_R	335_W	0.820	0.83
141_Q	288_D	0.819	0.83
207_A	210_E	0.817	0.83
87_E	90_R	0.815	0.82
134_R	652_N	0.814	0.82
173_N	601_A	0.814	0.82
411_F	479_L	0.814	0.82
58_T	61_A	0.813	0.82
235_D	241_K	0.811	0.82
119_V	136_V	0.810	0.82
297_A	301_M	0.809	0.82
359_Y	532_L	0.808	0.82
391_Y	430_F	0.807	0.82
310_Q	313_S	0.805	0.82
314_D	317_A	0.805	0.82
233_M	238_T	0.801	0.81
323_I	328_G	0.801	0.81
516_A	533_Q	0.799	0.81
266_V	561_W	0.798	0.81
382_F	411_F	0.798	0.81
399_E	410_L	0.797	0.81
145_L	278_F	0.797	0.81
60_L	64_Q	0.795	0.81
54_D	57_N	0.794	0.81
347_E	350_D	0.794	0.81
194_A	235_D	0.793	0.81
556_L	586_M	0.792	0.81
311_R	545_G	0.790	0.80
80_T	84_T	0.789	0.80
123_R	133_I	0.789	0.80
53_P	118_A	0.788	0.80
435_T	484_R	0.788	0.80
375_N	380_I	0.788	0.80
551_L	616_L	0.787	0.80
46_I	65_S	0.787	0.80
161_L	271_Q	0.786	0.80
644_R	649_S	0.786	0.80
608_Y	615_Y	0.786	0.80
28_Y	76_F	0.786	0.80
181_K	420_S	0.783	0.80
504_I	625_G	0.783	0.80
272_Q	284_W	0.782	0.80
660_Y	668_P	0.782	0.80
108_L	159_K	0.781	0.80
40_R	102_L	0.781	0.80
24_A	30_P	0.780	0.80
507_H	676_H	0.780	0.80
507_H	626_Y	0.780	0.80
346_R	352_D	0.780	0.80
171_Q	174_Q	0.778	0.79
125_S	136_V	0.777	0.79
544_K	548_M	0.777	0.79
211_K	419_D	0.777	0.79
385_R	388_I	0.776	0.79
192_Q	237_A	0.775	0.79
46_I	61_A	0.773	0.79
184_G	211_K	0.773	0.79
243_F	247_W	0.773	0.79
350_D	535_K	0.772	0.79
374_A	382_F	0.767	0.78
574_D	597_S	0.763	0.78
240_E	335_W	0.763	0.78
279_P	295_E	0.761	0.78
189_D	217_W	0.761	0.78
59_I	136_V	0.761	0.78
316_L	337_W	0.760	0.78
126_L	136_V	0.760	0.78
671_M	675_Q	0.760	0.78
141_Q	287_A	0.759	0.78
655_D	658_R	0.759	0.78
187_V	229_A	0.754	0.77
373_T	514_V	0.754	0.77
470_H	499_E	0.754	0.77
579_R	587_D	0.754	0.77
520_R	527_A	0.754	0.77
408_L	479_L	0.753	0.77
55_F	59_I	0.753	0.77
187_V	193_L	0.752	0.77
349_F	539_A	0.752	0.77
111_E	114_A	0.751	0.77
411_F	445_N	0.751	0.77
40_R	98_E	0.751	0.77
602_H	612_Y	0.750	0.77
134_R	137_E	0.750	0.77
196_M	229_A	0.749	0.77
363_N	396_R	0.747	0.77
42_E	65_S	0.746	0.76
120_W	137_E	0.746	0.76
73_T	77_F	0.746	0.76
124_E	133_I	0.746	0.76
311_R	679_L	0.745	0.76
360_F	462_W	0.745	0.76
666_K	669_K	0.743	0.76
375_N	382_F	0.743	0.76
320_Q	332_A	0.743	0.76
138_V	141_Q	0.741	0.76
208_A	218_L	0.740	0.76
23_I	31_A	0.740	0.76
199_Q	354_A	0.739	0.76
179_A	252_K	0.738	0.76
299_N	302_R	0.738	0.76
85_N	420_S	0.738	0.76
197_S	200_E	0.737	0.76
270_A	566_E	0.735	0.75
355_Q	532_L	0.734	0.75
427_M	443_I	0.733	0.75
164_E	260_A	0.732	0.75
344_V	349_F	0.731	0.75
583_A	586_M	0.731	0.75
82_A	391_Y	0.727	0.75
582_V	586_M	0.727	0.75
28_Y	88_L	0.727	0.75
17_A	410_L	0.726	0.75
632_Q	638_E	0.726	0.75
187_V	217_W	0.726	0.75
322_V	344_V	0.725	0.74
63_E	486_A	0.724	0.74
379_G	402_D	0.724	0.74
171_Q	261_I	0.723	0.74
628_W	631_E	0.722	0.74
374_A	476_L	0.722	0.74
38_Q	41_A	0.720	0.74
134_R	655_D	0.719	0.74
490_G	498_V	0.718	0.74
551_L	554_A	0.718	0.74
628_W	664_R	0.717	0.74
388_I	397_V	0.716	0.73
528_M	532_L	0.716	0.73
113_F	120_W	0.714	0.73
314_D	318_S	0.714	0.73
650_R	653_S	0.713	0.73
78_A	430_F	0.713	0.73
628_W	636_T	0.713	0.73
236_R	336_D	0.712	0.73
560_R	585_N	0.710	0.73
416_F	458_A	0.709	0.73
461_L	464_D	0.709	0.73
137_E	141_Q	0.708	0.73
123_R	137_E	0.708	0.73
332_A	337_W	0.706	0.72
552_L	616_L	0.706	0.72
374_A	400_I	0.705	0.72
638_E	645_E	0.705	0.72
83_H	88_L	0.705	0.72
313_S	320_Q	0.703	0.72
384_E	387_D	0.703	0.72
188_N	192_Q	0.702	0.72
519_A	528_M	0.701	0.72
511_H	634_G	0.701	0.72
602_H	615_Y	0.700	0.72
385_R	397_V	0.700	0.72
281_Y	285_K	0.700	0.72
196_M	200_E	0.699	0.72
531_E	535_K	0.699	0.72
315_E	543_N	0.697	0.71
231_A	545_G	0.696	0.71
78_A	82_A	0.696	0.71
471_E	474_H	0.696	0.71
600_F	612_Y	0.695	0.71
85_N	88_L	0.695	0.71
95_F	98_E	0.694	0.71
601_A	605_G	0.693	0.71
165_A	268_I	0.693	0.71
200_E	229_A	0.692	0.71
32_F	91_L	0.692	0.71
209_R	454_A	0.691	0.71
274_T	279_P	0.690	0.71
398_W	413_G	0.690	0.71
270_A	565_E	0.689	0.71
61_A	136_V	0.688	0.70
55_F	61_A	0.686	0.70
155_K	654_E	0.685	0.70
274_T	566_E	0.684	0.70
560_R	581_L	0.682	0.70
84_T	89_Q	0.680	0.70
167_T	264_R	0.680	0.70
139_I	142_R	0.677	0.69
160_V	163_T	0.677	0.69
270_A	564_L	0.677	0.69
345_R	542_F	0.674	0.69
194_A	339_F	0.673	0.69
154_D	274_T	0.672	0.69
385_R	410_L	0.672	0.69
404_N	644_R	0.671	0.69
301_M	556_L	0.671	0.69
110_G	151_A	0.670	0.68
416_F	452_P	0.670	0.68
534_Q	537_R	0.669	0.68
324_D	329_G	0.668	0.68
459_L	521_H	0.666	0.68
632_Q	642_R	0.665	0.68
203_L	451_K	0.664	0.68
101_E	105_D	0.663	0.68
645_E	650_R	0.663	0.68
36_M	102_L	0.662	0.68
43_I	109_N	0.662	0.68
415_F	468_L	0.662	0.68
373_T	469_F	0.659	0.67
361_E	520_R	0.659	0.67
123_R	127_G	0.658	0.67
470_H	615_Y	0.658	0.67
507_H	623_D	0.657	0.67
569_A	572_D	0.657	0.67
320_Q	330_F	0.657	0.67
560_R	582_V	0.654	0.67
552_L	556_L	0.654	0.67
483_Q	653_S	0.653	0.67
334_P	591_I	0.652	0.66
546_Y	549_S	0.651	0.66
39_K	106_I	0.648	0.66
208_A	212_G	0.647	0.66
51_Q	57_N	0.647	0.66
432_E	489_S	0.646	0.66
549_S	552_L	0.646	0.66
431_V	439_T	0.646	0.66
620_M	668_P	0.645	0.66
77_F	99_L	0.645	0.66
581_L	584_E	0.645	0.66
553_S	583_A	0.644	0.65
360_F	528_M	0.644	0.65
116_V	139_I	0.644	0.65
381_K	405_G	0.644	0.65
324_D	328_G	0.644	0.65
258_T	261_I	0.642	0.65
449_Y	458_A	0.640	0.65
323_I	327_Q	0.639	0.65
470_H	474_H	0.639	0.65
600_F	603_I	0.639	0.65
286_I	291_A	0.638	0.65
96_S	100_A	0.638	0.65
36_M	99_L	0.638	0.65
403_H	641_L	0.638	0.65
477_H	501_P	0.638	0.65
306_P	313_S	0.637	0.65
227_Q	338_A	0.636	0.64
36_M	40_R	0.636	0.64
491_T	498_V	0.634	0.64
319_I	332_A	0.633	0.64
322_V	326_Q	0.633	0.64
243_F	335_W	0.633	0.64
84_T	420_S	0.632	0.64
561_W	603_I	0.632	0.64
78_A	428_G	0.632	0.64
316_L	589_P	0.632	0.64
278_F	284_W	0.631	0.64
565_E	568_E	0.630	0.64
78_A	391_Y	0.629	0.64
194_A	343_Q	0.629	0.64
626_Y	647_I	0.629	0.64
274_T	280_H	0.629	0.64
67_E	71_R	0.628	0.63
428_G	446_V	0.627	0.63
546_Y	588_L	0.625	0.63
160_V	271_Q	0.625	0.63
557_L	561_W	0.624	0.63
318_S	344_V	0.624	0.63
413_G	445_N	0.622	0.63
119_V	126_L	0.621	0.63
508_W	634_G	0.619	0.62
443_I	491_T	0.619	0.62
36_M	39_K	0.619	0.62
208_A	213_L	0.619	0.62
526_A	531_E	0.618	0.62
580_A	597_S	0.618	0.62
410_L	440_H	0.618	0.62
546_Y	550_E	0.617	0.62
130_S	133_I	0.617	0.62
471_E	506_E	0.616	0.62
35_G	39_K	0.615	0.62
358_P	523_Q	0.615	0.62
64_Q	434_S	0.614	0.62
98_E	101_E	0.614	0.62
391_Y	446_V	0.614	0.62
294_P	563_C	0.614	0.62
638_E	641_L	0.614	0.62
500_F	504_I	0.613	0.62
283_A	563_C	0.613	0.62
418_R	421_K	0.613	0.62
467_T	602_H	0.613	0.62
643_F	647_I	0.612	0.62
381_K	402_D	0.611	0.61
548_M	555_A	0.611	0.61
608_Y	612_Y	0.611	0.61
105_D	109_N	0.610	0.61
580_A	589_P	0.609	0.61
90_R	93_E	0.608	0.61
578_L	586_M	0.608	0.61
601_A	614_A	0.607	0.61
179_A	183_G	0.607	0.61
422_S	426_W	0.606	0.61
209_R	212_G	0.606	0.61
366_L	382_F	0.605	0.61
242_L	246_G	0.604	0.60
94_Q	97_A	0.604	0.60
30_P	41_A	0.603	0.60
63_E	66_G	0.603	0.60
474_H	499_E	0.602	0.60
20_F	23_I	0.602	0.60
102_L	105_D	0.601	0.60
116_V	140_H	0.601	0.60
471_E	499_E	0.601	0.60
53_P	58_T	0.601	0.60
185_L	238_T	0.601	0.60
187_V	219_I	0.600	0.60
307_A	670_I	0.599	0.60
289_Q	618_T	0.599	0.60
399_E	409_A	0.598	0.60
37_Q	40_R	0.598	0.60
491_T	495_R	0.597	0.60
322_V	543_N	0.597	0.60
634_G	639_N	0.596	0.59
368_E	375_N	0.596	0.59
420_S	559_M	0.595	0.59
151_A	155_K	0.594	0.59
23_I	75_V	0.594	0.59
188_N	214_D	0.594	0.59
302_R	306_P	0.594	0.59
500_F	505_N	0.593	0.59
92_D	170_S	0.593	0.59
625_G	660_Y	0.591	0.59
310_Q	314_D	0.591	0.59
432_E	486_A	0.590	0.59
324_D	331_S	0.589	0.59
195_G	233_M	0.588	0.58
84_T	92_D	0.587	0.58
200_E	228_P	0.587	0.58
575_D	581_L	0.587	0.58
508_W	626_Y	0.587	0.58
477_H	493_T	0.585	0.58
191_A	201_I	0.585	0.58
285_K	609_A	0.584	0.58
30_P	33_D	0.583	0.58
42_E	45_A	0.583	0.58
208_A	217_W	0.583	0.58
466_I	509_A	0.583	0.58
356_L	532_L	0.582	0.58
36_M	98_E	0.582	0.58
112_L	143_F	0.582	0.58
53_P	57_N	0.580	0.57
60_L	135_L	0.578	0.57
413_G	475_T	0.577	0.57
316_L	588_L	0.576	0.57
265_L	609_A	0.576	0.57
584_E	589_P	0.573	0.57
187_V	192_Q	0.572	0.56
429_N	489_S	0.572	0.56
203_L	207_A	0.572	0.56
379_G	403_H	0.572	0.56
81_A	428_G	0.572	0.56
508_W	635_L	0.571	0.56
196_M	219_I	0.571	0.56
612_Y	615_Y	0.571	0.56
345_R	353_E	0.570	0.56
532_L	536_M	0.570	0.56
57_N	115_R	0.568	0.56
427_M	491_T	0.568	0.56
193_L	201_I	0.568	0.56
75_V	79_M	0.567	0.56
302_R	560_R	0.567	0.56
290_M	500_F	0.567	0.56
296_A	300_F	0.567	0.56
544_K	547_E	0.566	0.56
482_R	645_E	0.566	0.56
320_Q	323_I	0.566	0.56
470_H	506_E	0.566	0.56
80_T	89_Q	0.566	0.56
211_K	220_P	0.565	0.55
39_K	42_E	0.565	0.55
62_L	139_I	0.565	0.55
301_M	552_L	0.565	0.55
145_L	288_D	0.564	0.55
642_R	662_Q	0.563	0.55
508_W	629_F	0.563	0.55
602_H	608_Y	0.563	0.55
70_T	432_E	0.563	0.55
52_M	122_R	0.562	0.55
326_Q	339_F	0.562	0.55
24_A	87_E	0.561	0.55
474_H	506_E	0.561	0.55
303_E	306_P	0.560	0.55
35_G	65_S	0.560	0.55
103_A	107_Y	0.560	0.55
271_Q	274_T	0.559	0.55
49_N	53_P	0.559	0.55
279_P	565_E	0.558	0.55
616_L	625_G	0.558	0.55
666_K	672_P	0.557	0.54
144_V	287_A	0.557	0.54
338_A	341_A	0.556	0.54
358_P	522_Y	0.556	0.54
138_V	487_T	0.556	0.54
378_F	648_L	0.555	0.54
356_L	528_M	0.555	0.54
427_M	498_V	0.555	0.54
70_T	429_N	0.554	0.54
308_A	649_S	0.554	0.54
238_T	241_K	0.554	0.54
315_E	545_G	0.552	0.54
121_Q	531_E	0.552	0.54
408_L	644_R	0.552	0.54
173_N	605_G	0.551	0.54
262_I	266_V	0.551	0.54
232_E	246_G	0.551	0.54
232_E	346_R	0.550	0.53
164_E	268_I	0.550	0.53
495_R	498_V	0.550	0.53
39_K	43_I	0.550	0.53
301_M	555_A	0.549	0.53
228_P	231_A	0.549	0.53
533_Q	537_R	0.549	0.53
548_M	673_M	0.549	0.53
304_I	670_I	0.549	0.53
74_S	486_A	0.548	0.53
236_R	240_E	0.548	0.53
299_N	393_P	0.547	0.53
537_R	540_S	0.546	0.53
499_E	615_Y	0.546	0.53
579_R	586_M	0.545	0.53
263_Q	573_V	0.545	0.53
623_D	673_M	0.545	0.53
308_A	549_S	0.545	0.53
306_P	310_Q	0.544	0.53
278_F	283_A	0.544	0.53
499_E	502_S	0.543	0.53
603_I	609_A	0.543	0.53
321_A	347_E	0.542	0.52
366_L	370_V	0.542	0.52
120_W	133_I	0.542	0.52
600_F	608_Y	0.541	0.52
411_F	475_T	0.541	0.52
581_L	586_M	0.540	0.52
72_V	99_L	0.539	0.52
237_A	241_K	0.539	0.52
495_R	614_A	0.538	0.52
116_V	119_V	0.538	0.52
545_G	548_M	0.538	0.52
327_Q	330_F	0.538	0.52
462_W	536_M	0.537	0.52
349_F	535_K	0.537	0.52
427_M	490_G	0.537	0.52
64_Q	486_A	0.537	0.52
187_V	190_I	0.537	0.52
45_A	191_A	0.536	0.52
499_E	506_E	0.536	0.52
62_L	106_I	0.536	0.52
628_W	639_N	0.536	0.52
621_L	660_Y	0.535	0.52
185_L	235_D	0.535	0.52
199_Q	357_K	0.534	0.51
422_S	614_A	0.533	0.51
565_E	569_A	0.533	0.51
289_Q	495_R	0.532	0.51
375_N	403_H	0.532	0.51
636_T	642_R	0.531	0.51
622_A	675_Q	0.531	0.51
368_E	520_R	0.531	0.51
74_S	492_N	0.529	0.51
543_N	546_Y	0.529	0.51
59_I	119_V	0.529	0.51
55_F	58_T	0.529	0.51
55_F	485_Y	0.528	0.51
312_A	652_N	0.528	0.51
304_I	616_L	0.528	0.51
417_A	424_G	0.528	0.51
319_I	344_V	0.527	0.50
325_K	328_G	0.526	0.50
236_R	323_I	0.526	0.50
305_V	549_S	0.525	0.50
386_F	389_P	0.525	0.50
635_L	640_G	0.524	0.50
624_D	660_Y	0.523	0.50
170_S	174_Q	0.523	0.50
502_S	602_H	0.522	0.50
104_N	159_K	0.522	0.50
655_D	659_L	0.521	0.50
27_H	72_V	0.521	0.50
291_A	617_W	0.521	0.50
23_I	30_P	0.521	0.50
449_Y	468_L	0.520	0.50
448_N	465_V	0.520	0.50
370_V	374_A	0.520	0.50
290_M	416_F	0.519	0.49
483_Q	489_S	0.519	0.49
318_S	321_A	0.519	0.49
39_K	46_I	0.518	0.49
121_Q	522_Y	0.518	0.49
185_L	188_N	0.517	0.49
202_A	206_E	0.517	0.49
349_F	536_M	0.517	0.49
19_H	389_P	0.517	0.49
221_L	245_A	0.516	0.49
226_Q	258_T	0.516	0.49
498_V	607_G	0.515	0.49
131_E	483_Q	0.515	0.49
548_M	551_L	0.515	0.49
388_I	391_Y	0.512	0.48
443_I	479_L	0.512	0.48
45_A	61_A	0.511	0.48
470_H	502_S	0.511	0.48
373_T	635_L	0.510	0.48
204_A	207_A	0.510	0.48
457_P	521_H	0.510	0.48
48_L	154_D	0.510	0.48
401_F	440_H	0.510	0.48
81_A	422_S	0.509	0.48
444_Y	447_C	0.508	0.48
31_A	72_V	0.508	0.48
138_V	488_L	0.507	0.48
76_F	91_L	0.507	0.48
67_E	70_T	0.507	0.48
189_D	235_D	0.506	0.48
510_T	540_S	0.506	0.48
122_R	133_I	0.506	0.48
191_A	393_P	0.506	0.48
381_K	406_V	0.505	0.48
381_K	403_H	0.505	0.48
321_A	348_K	0.505	0.48
195_G	234_R	0.504	0.47
180_N	249_R	0.504	0.47
514_V	517_R	0.504	0.47
644_R	648_L	0.503	0.47
186_V	214_D	0.503	0.47
409_A	440_H	0.503	0.47
266_V	564_L	0.502	0.47
17_A	442_V	0.502	0.47
158_L	276_L	0.501	0.47
17_A	389_P	0.501	0.47
557_L	597_S	0.501	0.47
447_C	458_A	0.501	0.47
248_T	252_K	0.500	0.47
396_R	468_L	0.500	0.47
557_L	579_R	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y791	1	0.9956	100	0.215	Contact Map
4ka7A	1	0.9853	100	0.22	Contact Map
2o3eA	1	0.9589	100	0.224	Contact Map
2o36A	1	0.9427	100	0.268	Contact Map
1r42A	1	0.7753	100	0.586	Contact Map
4ca6A	1	0.7885	100	0.592	Contact Map
4c2oA	1	0.7621	100	0.606	Contact Map
3sksA	1	0.7665	100	0.61	Contact Map
3ahnA	1	0.7827	100	0.616	Contact Map
2qr4A	2	0.721	100	0.621	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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