GREMLIN Database
MAK - Fructokinase
UniProt: P23917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11288
Length: 302 (288)
Sequences: 12561 (9667)
Seq/√Len: 569.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_P90_K3.3771.00
103_A146_I3.2951.00
26_R289_S3.2181.00
18_G22_E3.1541.00
44_A95_R2.7861.00
184_I235_S2.6471.00
230_L267_L2.5701.00
119_A125_V2.5681.00
122_A247_V2.5091.00
15_I292_V2.4961.00
247_V282_R2.4881.00
149_N244_D2.4741.00
17_L296_A2.4441.00
178_C183_C2.4101.00
127_A251_G2.3601.00
110_A137_G2.3101.00
69_S72_T2.2831.00
89_D93_S2.2771.00
126_F239_V2.2561.00
109_L127_A2.2551.00
226_R263_T2.1881.00
176_C183_C2.1321.00
27_H49_M2.0771.00
110_A139_A2.0591.00
14_V46_L2.0571.00
158_N238_H2.0411.00
196_D227_R2.0291.00
103_A107_N1.9501.00
59_T299_W1.9331.00
140_F145_H1.9281.00
124_T246_D1.9071.00
116_D297_W1.9011.00
3_I47_V1.8711.00
103_A108_C1.8461.00
48_D95_R1.8221.00
233_A267_L1.8151.00
41_E95_R1.8131.00
91_D94_A1.7951.00
14_V50_A1.7811.00
90_K94_A1.7711.00
261_Y265_G1.7411.00
267_L270_Q1.7391.00
148_G246_D1.7301.00
236_L248_I1.7301.00
229_E264_V1.7261.00
215_E259_R1.7031.00
268_I281_V1.6771.00
157_H178_C1.6741.00
206_K209_E1.6731.00
60_V96_L1.6631.00
86_Q91_D1.6571.00
213_L218_D1.6441.00
229_E263_T1.6361.00
229_E233_A1.6281.00
159_P238_H1.6161.00
112_S286_H1.6131.00
175_P181_Q1.6051.00
123_Q141_N1.5961.00
63_G108_C1.5831.00
123_Q246_D1.5741.00
212_R216_E1.5721.00
247_V280_P1.5671.00
4_G292_V1.5591.00
27_H53_A1.5551.00
114_A125_V1.5521.00
25_Y53_A1.5391.00
265_G269_K1.4911.00
122_A246_D1.4731.00
161_P172_E1.4571.00
32_P42_T1.4541.00
193_F228_Y1.4481.00
263_T266_Q1.4431.00
261_Y283_K1.4351.00
258_D262_Q1.4131.00
208_S212_R1.4121.00
157_H176_C1.4051.00
48_D96_L1.3961.00
125_V139_A1.3931.00
176_C179_G1.3881.00
5_I14_V1.3831.00
174_V195_M1.3741.00
234_K238_H1.3711.00
240_V268_I1.3701.00
196_D199_R1.3301.00
200_L223_L1.3281.00
44_A96_L1.3141.00
60_V98_R1.3121.00
11_K28_R1.3121.00
110_A125_V1.3081.00
41_E45_T1.2911.00
103_A298_L1.2801.00
115_V297_W1.2791.00
157_H183_C1.2781.00
25_Y50_A1.2771.00
130_I232_L1.2771.00
240_V248_I1.2771.00
62_M92_L1.2711.00
226_R267_L1.2681.00
124_T140_F1.2591.00
128_V236_L1.2561.00
11_K190_G1.2491.00
91_D95_R1.2481.00
122_A125_V1.2391.00
197_Y224_A1.2191.00
239_V242_I1.1971.00
44_A48_D1.1851.00
15_I23_Q1.1811.00
267_L271_F1.1801.00
113_E117_G1.1731.00
209_E212_R1.1711.00
114_A139_A1.1691.00
126_F136_A1.1671.00
17_L23_Q1.1611.00
107_N144_A1.1571.00
40_I91_D1.1521.00
35_D38_Q1.1351.00
263_T267_L1.1261.00
63_G291_G1.1251.00
214_V225_L1.1221.00
29_L46_L1.1141.00
27_H46_L1.1131.00
197_Y221_A1.1091.00
29_L42_T1.1081.00
108_C295_A1.1081.00
125_V249_V1.1021.00
124_T145_H1.0991.00
4_G295_A1.0861.00
110_A127_A1.0831.00
134_C188_I1.0761.00
5_I43_I1.0731.00
266_Q270_Q1.0721.00
29_L49_M1.0711.00
74_V87_P1.0711.00
46_L49_M1.0691.00
87_P91_D1.0571.00
196_D224_A1.0511.00
250_L255_S1.0451.00
196_D200_L1.0371.00
42_T45_T1.0241.00
49_M53_A1.0231.00
106_A129_I1.0141.00
161_P171_R1.0111.00
104_N154_E1.0111.00
214_V222_E1.0081.00
4_G61_G1.0071.00
174_V186_T1.0071.00
222_E226_R1.0061.00
120_A285_K1.0051.00
29_L45_T1.0001.00
258_D283_K0.9981.00
57_R98_R0.9961.00
13_E28_R0.9881.00
262_Q265_G0.9851.00
256_N288_D0.9841.00
101_R299_W0.9831.00
37_R91_D0.9811.00
226_R266_Q0.9801.00
126_F138_V0.9781.00
5_I47_V0.9761.00
9_G132_T0.9701.00
16_A54_T0.9681.00
174_V196_D0.9651.00
136_A155_W0.9641.00
215_E258_D0.9611.00
249_V284_A0.9581.00
114_A142_G0.9561.00
249_V282_R0.9561.00
211_I225_L0.9551.00
138_V243_L0.9521.00
236_L250_L0.9511.00
229_E267_L0.9501.00
174_V187_F0.9471.00
201_S204_A0.9461.00
262_Q266_Q0.9441.00
126_F248_I0.9441.00
269_K278_E0.9421.00
107_N154_E0.9381.00
161_P234_K0.9381.00
45_T49_M0.9301.00
138_V145_H0.9301.00
74_V85_G0.9251.00
174_V199_R0.9231.00
36_Y91_D0.9221.00
3_I57_R0.9211.00
18_G24_L0.9191.00
125_V247_V0.9181.00
4_G296_A0.9171.00
116_D293_R0.9131.00
147_G152_A0.9081.00
147_G244_D0.9051.00
93_S100_V0.9021.00
109_L291_G0.9011.00
92_L100_V0.8981.00
212_R215_E0.8981.00
236_L268_I0.8951.00
39_T83_L0.8931.00
17_L293_R0.8911.00
230_L234_K0.8811.00
138_V153_G0.8761.00
183_C186_T0.8661.00
69_S76_K0.8641.00
12_T31_T0.8631.00
123_Q142_G0.8601.00
256_N283_K0.8521.00
198_R203_H0.8521.00
73_G89_D0.8501.00
16_A50_A0.8451.00
227_R231_R0.8431.00
240_V279_T0.8421.00
7_L64_I0.8401.00
122_A280_P0.8321.00
23_Q26_R0.8291.00
214_V259_R0.8271.00
64_I68_I0.8241.00
36_Y86_Q0.8211.00
261_Y264_V0.8191.00
117_G120_A0.8161.00
126_F245_P0.8151.00
184_I228_Y0.8151.00
193_F254_M0.8121.00
211_I215_E0.8111.00
133_G154_E0.8081.00
7_L43_I0.8081.00
38_Q41_E0.8071.00
141_N145_H0.8061.00
64_I75_V0.8031.00
213_L221_A0.8021.00
233_A271_F0.8011.00
201_S205_L0.8001.00
234_K271_F0.7901.00
124_T141_N0.7891.00
223_L227_R0.7891.00
218_D221_A0.7871.00
133_G185_E0.7851.00
197_Y210_I0.7841.00
147_G153_G0.7831.00
209_E213_L0.7821.00
48_D51_E0.7811.00
14_V27_H0.7791.00
44_A91_D0.7771.00
241_N273_F0.7761.00
220_V223_L0.7751.00
93_S99_E0.7691.00
25_Y54_T0.7681.00
196_D228_Y0.7671.00
124_T148_G0.7661.00
129_I291_G0.7651.00
59_T99_E0.7631.00
160_L231_R0.7581.00
161_P187_F0.7501.00
93_S97_Q0.7451.00
106_A137_G0.7431.00
111_V114_A0.7381.00
205_L209_E0.7351.00
233_A268_I0.7331.00
250_L281_V0.7321.00
105_D135_G0.7321.00
117_G121_G0.7261.00
104_N133_G0.7261.00
13_E26_R0.7241.00
37_R41_E0.7221.00
45_T48_D0.7191.00
131_G253_G0.7171.00
282_R285_K0.7171.00
219_P223_L0.7171.00
211_I257_V0.7161.00
8_G253_G0.7151.00
232_L264_V0.7111.00
194_A198_R0.7091.00
200_L220_V0.7091.00
61_G108_C0.7071.00
119_A249_V0.7021.00
213_L216_E0.7011.00
51_E98_R0.7001.00
214_V221_A0.6971.00
15_I26_R0.6961.00
73_G93_S0.6961.00
8_G132_T0.6931.00
286_H293_R0.6891.00
187_F231_R0.6891.00
237_A271_F0.6881.00
108_C298_L0.6871.00
159_P234_K0.6871.00
118_A285_K0.6851.00
161_P174_V0.6851.00
127_A249_V0.6821.00
230_L270_Q0.6811.00
224_A228_Y0.6791.00
287_G290_S0.6761.00
7_L39_T0.6761.00
116_D286_H0.6751.00
40_I86_Q0.6721.00
7_L12_T0.6721.00
77_N84_N0.6711.00
180_K271_F0.6691.00
160_L235_S0.6691.00
260_L263_T0.6671.00
40_I95_R0.6641.00
89_D102_L0.6641.00
200_L224_A0.6641.00
118_A249_V0.6621.00
222_E259_R0.6621.00
194_A207_G0.6611.00
118_A282_R0.6611.00
190_G194_A0.6601.00
5_I60_V0.6581.00
192_G195_M0.6551.00
219_P222_E0.6541.00
152_A244_D0.6511.00
194_A210_I0.6461.00
12_T29_L0.6451.00
46_L50_A0.6421.00
259_R262_Q0.6391.00
230_L271_F0.6381.00
14_V29_L0.6381.00
158_N235_S0.6371.00
233_A237_A0.6361.00
3_I51_E0.6351.00
237_A268_I0.6321.00
228_Y260_L0.6321.00
61_G299_W0.6311.00
32_P38_Q0.6311.00
128_V136_A0.6261.00
259_R263_T0.6241.00
90_K93_S0.6231.00
180_K183_C0.6221.00
38_Q42_T0.6221.00
36_Y83_L0.6191.00
12_T43_I0.6181.00
161_P173_E0.6181.00
113_E284_A0.6161.00
265_G280_P0.6161.00
188_I228_Y0.6151.00
48_D52_Q0.6151.00
160_L187_F0.6141.00
137_G144_A0.6141.00
43_I92_L0.6111.00
198_R204_A0.6091.00
266_Q269_K0.6071.00
42_T46_L0.6051.00
195_M199_R0.6051.00
179_G183_C0.6031.00
237_A241_N0.6031.00
185_E189_S0.6001.00
193_F224_A0.5971.00
159_P180_K0.5951.00
97_Q100_V0.5951.00
229_E260_L0.5921.00
192_G196_D0.5891.00
67_S78_A0.5891.00
176_C180_K0.5881.00
27_H50_A0.5861.00
286_H290_S0.5861.00
176_C182_G0.5851.00
6_D9_G0.5841.00
191_T195_M0.5811.00
193_F210_I0.5791.00
176_C186_T0.5781.00
190_G254_M0.5781.00
145_H243_L0.5761.00
236_L264_V0.5751.00
113_E286_H0.5751.00
50_A54_T0.5731.00
112_S297_W0.5710.99
214_V229_E0.5710.99
210_I214_V0.5660.99
196_D231_R0.5640.99
148_G244_D0.5640.99
293_R296_A0.5640.99
44_A92_L0.5620.99
51_E57_R0.5590.99
109_L251_G0.5590.99
89_D100_V0.5550.99
251_G284_A0.5520.99
9_G105_D0.5520.99
13_E292_V0.5510.99
161_P231_R0.5500.99
113_E285_K0.5490.99
101_R298_L0.5490.99
105_D129_I0.5470.99
224_A227_R0.5460.99
10_T132_T0.5440.99
214_V217_S0.5440.99
135_G154_E0.5440.99
218_D222_E0.5430.99
155_W242_I0.5430.99
171_R234_K0.5410.99
9_G129_I0.5370.99
94_A97_Q0.5370.99
157_H179_G0.5340.99
104_N107_N0.5330.99
117_G282_R0.5320.99
279_T283_K0.5310.99
16_A57_R0.5310.99
76_K85_G0.5310.99
92_L96_L0.5300.99
104_N135_G0.5300.99
127_A131_G0.5280.99
148_G245_P0.5270.99
264_V268_I0.5260.99
222_E263_T0.5260.99
200_L227_R0.5260.99
83_L86_Q0.5240.99
158_N239_V0.5230.99
65_P79_N0.5200.99
140_F245_P0.5200.99
128_V155_W0.5190.99
258_D265_G0.5190.99
104_N129_I0.5180.99
109_L129_I0.5180.99
60_V92_L0.5170.99
67_S76_K0.5150.99
203_H209_E0.5150.99
23_Q293_R0.5150.99
79_N82_W0.5140.99
59_T101_R0.5130.99
70_P146_I0.5120.99
230_L263_T0.5110.99
245_P248_I0.5110.99
70_P150_G0.5070.99
207_G211_I0.5060.99
13_E190_G0.5060.99
31_T39_T0.5060.99
73_G87_P0.5060.99
139_A144_A0.5060.99
130_I254_M0.5060.99
184_I232_L0.5050.99
6_D253_G0.5050.99
160_L184_I0.5030.99
188_I232_L0.5020.99
128_V239_V0.5020.99
117_G286_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9669 100 0.169 Contact Map
2ap1A 2 1 100 0.172 Contact Map
1z6rA 3 0.9669 100 0.179 Contact Map
4db3A 2 0.9702 100 0.185 Contact Map
3vglA 3 0.9636 100 0.187 Contact Map
2yhwA 2 0.9503 100 0.187 Contact Map
3vovA 3 0.957 100 0.188 Contact Map
2qm1A 2 0.9702 100 0.191 Contact Map
4htlA 4 0.9404 100 0.207 Contact Map
2aa4A 2 0.947 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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