MAK - ECOLI - GREMLIN Contacts

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MAK - Fructokinase

UniProt:	P23917	Sequences: MRIGIDLGGTKTEVIALGDAGEQLYRHRLPTPRDDYRQTIETIATLVDMAEQATGQRGTVGMGIPGSISPYTGVVKNANSTWLNGQPFDKDLSARLQREVRLANDANCLAVSEAVDGAAAGAQTVFAVIIGTGCGAGVAFNGRAHIGGNGTAGEWGHNPLPWMDEDELRYREEVPCYCGKQGCIETFISGTGFAMDYRRLSGHALKGSEIIRLVEESDPVAELALRRYELRLAKSLAHVVNILDPDVIVLGGGMSNVDRLYQTVGQLIKQFVFGGECETPVRKAKHGDSSGVRGAAWLWPQE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11288
Length:	302 (288)
Sequences:	12561 (9667)
Seq/√Len:	569.6

ECOLI - MAK NAGK MLC NANK NAGC YPHH ALSK
BACSU - GLK XYLR SCRK
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
87_P	90_K	3.377	1.00
103_A	146_I	3.295	1.00
26_R	289_S	3.218	1.00
18_G	22_E	3.154	1.00
44_A	95_R	2.786	1.00
184_I	235_S	2.647	1.00
230_L	267_L	2.570	1.00
119_A	125_V	2.568	1.00
122_A	247_V	2.509	1.00
15_I	292_V	2.496	1.00
247_V	282_R	2.488	1.00
149_N	244_D	2.474	1.00
17_L	296_A	2.444	1.00
178_C	183_C	2.410	1.00
127_A	251_G	2.360	1.00
110_A	137_G	2.310	1.00
69_S	72_T	2.283	1.00
89_D	93_S	2.277	1.00
126_F	239_V	2.256	1.00
109_L	127_A	2.255	1.00
226_R	263_T	2.188	1.00
176_C	183_C	2.132	1.00
27_H	49_M	2.077	1.00
110_A	139_A	2.059	1.00
14_V	46_L	2.057	1.00
158_N	238_H	2.041	1.00
196_D	227_R	2.029	1.00
103_A	107_N	1.950	1.00
59_T	299_W	1.933	1.00
140_F	145_H	1.928	1.00
124_T	246_D	1.907	1.00
116_D	297_W	1.901	1.00
3_I	47_V	1.871	1.00
103_A	108_C	1.846	1.00
48_D	95_R	1.822	1.00
233_A	267_L	1.815	1.00
41_E	95_R	1.813	1.00
91_D	94_A	1.795	1.00
14_V	50_A	1.781	1.00
90_K	94_A	1.771	1.00
261_Y	265_G	1.741	1.00
267_L	270_Q	1.739	1.00
148_G	246_D	1.730	1.00
236_L	248_I	1.730	1.00
229_E	264_V	1.726	1.00
215_E	259_R	1.703	1.00
268_I	281_V	1.677	1.00
157_H	178_C	1.674	1.00
206_K	209_E	1.673	1.00
60_V	96_L	1.663	1.00
86_Q	91_D	1.657	1.00
213_L	218_D	1.644	1.00
229_E	263_T	1.636	1.00
229_E	233_A	1.628	1.00
159_P	238_H	1.616	1.00
112_S	286_H	1.613	1.00
175_P	181_Q	1.605	1.00
123_Q	141_N	1.596	1.00
63_G	108_C	1.583	1.00
123_Q	246_D	1.574	1.00
212_R	216_E	1.572	1.00
247_V	280_P	1.567	1.00
4_G	292_V	1.559	1.00
27_H	53_A	1.555	1.00
114_A	125_V	1.552	1.00
25_Y	53_A	1.539	1.00
265_G	269_K	1.491	1.00
122_A	246_D	1.473	1.00
161_P	172_E	1.457	1.00
32_P	42_T	1.454	1.00
193_F	228_Y	1.448	1.00
263_T	266_Q	1.443	1.00
261_Y	283_K	1.435	1.00
258_D	262_Q	1.413	1.00
208_S	212_R	1.412	1.00
157_H	176_C	1.405	1.00
48_D	96_L	1.396	1.00
125_V	139_A	1.393	1.00
176_C	179_G	1.388	1.00
5_I	14_V	1.383	1.00
174_V	195_M	1.374	1.00
234_K	238_H	1.371	1.00
240_V	268_I	1.370	1.00
196_D	199_R	1.330	1.00
200_L	223_L	1.328	1.00
44_A	96_L	1.314	1.00
60_V	98_R	1.312	1.00
11_K	28_R	1.312	1.00
110_A	125_V	1.308	1.00
41_E	45_T	1.291	1.00
103_A	298_L	1.280	1.00
115_V	297_W	1.279	1.00
157_H	183_C	1.278	1.00
25_Y	50_A	1.277	1.00
130_I	232_L	1.277	1.00
240_V	248_I	1.277	1.00
62_M	92_L	1.271	1.00
226_R	267_L	1.268	1.00
124_T	140_F	1.259	1.00
128_V	236_L	1.256	1.00
11_K	190_G	1.249	1.00
91_D	95_R	1.248	1.00
122_A	125_V	1.239	1.00
197_Y	224_A	1.219	1.00
239_V	242_I	1.197	1.00
44_A	48_D	1.185	1.00
15_I	23_Q	1.181	1.00
267_L	271_F	1.180	1.00
113_E	117_G	1.173	1.00
209_E	212_R	1.171	1.00
114_A	139_A	1.169	1.00
126_F	136_A	1.167	1.00
17_L	23_Q	1.161	1.00
107_N	144_A	1.157	1.00
40_I	91_D	1.152	1.00
35_D	38_Q	1.135	1.00
263_T	267_L	1.126	1.00
63_G	291_G	1.125	1.00
214_V	225_L	1.122	1.00
29_L	46_L	1.114	1.00
27_H	46_L	1.113	1.00
197_Y	221_A	1.109	1.00
29_L	42_T	1.108	1.00
108_C	295_A	1.108	1.00
125_V	249_V	1.102	1.00
124_T	145_H	1.099	1.00
4_G	295_A	1.086	1.00
110_A	127_A	1.083	1.00
134_C	188_I	1.076	1.00
5_I	43_I	1.073	1.00
266_Q	270_Q	1.072	1.00
29_L	49_M	1.071	1.00
74_V	87_P	1.071	1.00
46_L	49_M	1.069	1.00
87_P	91_D	1.057	1.00
196_D	224_A	1.051	1.00
250_L	255_S	1.045	1.00
196_D	200_L	1.037	1.00
42_T	45_T	1.024	1.00
49_M	53_A	1.023	1.00
106_A	129_I	1.014	1.00
161_P	171_R	1.011	1.00
104_N	154_E	1.011	1.00
214_V	222_E	1.008	1.00
4_G	61_G	1.007	1.00
174_V	186_T	1.007	1.00
222_E	226_R	1.006	1.00
120_A	285_K	1.005	1.00
29_L	45_T	1.000	1.00
258_D	283_K	0.998	1.00
57_R	98_R	0.996	1.00
13_E	28_R	0.988	1.00
262_Q	265_G	0.985	1.00
256_N	288_D	0.984	1.00
101_R	299_W	0.983	1.00
37_R	91_D	0.981	1.00
226_R	266_Q	0.980	1.00
126_F	138_V	0.978	1.00
5_I	47_V	0.976	1.00
9_G	132_T	0.970	1.00
16_A	54_T	0.968	1.00
174_V	196_D	0.965	1.00
136_A	155_W	0.964	1.00
215_E	258_D	0.961	1.00
249_V	284_A	0.958	1.00
114_A	142_G	0.956	1.00
249_V	282_R	0.956	1.00
211_I	225_L	0.955	1.00
138_V	243_L	0.952	1.00
236_L	250_L	0.951	1.00
229_E	267_L	0.950	1.00
174_V	187_F	0.947	1.00
201_S	204_A	0.946	1.00
262_Q	266_Q	0.944	1.00
126_F	248_I	0.944	1.00
269_K	278_E	0.942	1.00
107_N	154_E	0.938	1.00
161_P	234_K	0.938	1.00
45_T	49_M	0.930	1.00
138_V	145_H	0.930	1.00
74_V	85_G	0.925	1.00
174_V	199_R	0.923	1.00
36_Y	91_D	0.922	1.00
3_I	57_R	0.921	1.00
18_G	24_L	0.919	1.00
125_V	247_V	0.918	1.00
4_G	296_A	0.917	1.00
116_D	293_R	0.913	1.00
147_G	152_A	0.908	1.00
147_G	244_D	0.905	1.00
93_S	100_V	0.902	1.00
109_L	291_G	0.901	1.00
92_L	100_V	0.898	1.00
212_R	215_E	0.898	1.00
236_L	268_I	0.895	1.00
39_T	83_L	0.893	1.00
17_L	293_R	0.891	1.00
230_L	234_K	0.881	1.00
138_V	153_G	0.876	1.00
183_C	186_T	0.866	1.00
69_S	76_K	0.864	1.00
12_T	31_T	0.863	1.00
123_Q	142_G	0.860	1.00
256_N	283_K	0.852	1.00
198_R	203_H	0.852	1.00
73_G	89_D	0.850	1.00
16_A	50_A	0.845	1.00
227_R	231_R	0.843	1.00
240_V	279_T	0.842	1.00
7_L	64_I	0.840	1.00
122_A	280_P	0.832	1.00
23_Q	26_R	0.829	1.00
214_V	259_R	0.827	1.00
64_I	68_I	0.824	1.00
36_Y	86_Q	0.821	1.00
261_Y	264_V	0.819	1.00
117_G	120_A	0.816	1.00
126_F	245_P	0.815	1.00
184_I	228_Y	0.815	1.00
193_F	254_M	0.812	1.00
211_I	215_E	0.811	1.00
133_G	154_E	0.808	1.00
7_L	43_I	0.808	1.00
38_Q	41_E	0.807	1.00
141_N	145_H	0.806	1.00
64_I	75_V	0.803	1.00
213_L	221_A	0.802	1.00
233_A	271_F	0.801	1.00
201_S	205_L	0.800	1.00
234_K	271_F	0.790	1.00
124_T	141_N	0.789	1.00
223_L	227_R	0.789	1.00
218_D	221_A	0.787	1.00
133_G	185_E	0.785	1.00
197_Y	210_I	0.784	1.00
147_G	153_G	0.783	1.00
209_E	213_L	0.782	1.00
48_D	51_E	0.781	1.00
14_V	27_H	0.779	1.00
44_A	91_D	0.777	1.00
241_N	273_F	0.776	1.00
220_V	223_L	0.775	1.00
93_S	99_E	0.769	1.00
25_Y	54_T	0.768	1.00
196_D	228_Y	0.767	1.00
124_T	148_G	0.766	1.00
129_I	291_G	0.765	1.00
59_T	99_E	0.763	1.00
160_L	231_R	0.758	1.00
161_P	187_F	0.750	1.00
93_S	97_Q	0.745	1.00
106_A	137_G	0.743	1.00
111_V	114_A	0.738	1.00
205_L	209_E	0.735	1.00
233_A	268_I	0.733	1.00
250_L	281_V	0.732	1.00
105_D	135_G	0.732	1.00
117_G	121_G	0.726	1.00
104_N	133_G	0.726	1.00
13_E	26_R	0.724	1.00
37_R	41_E	0.722	1.00
45_T	48_D	0.719	1.00
131_G	253_G	0.717	1.00
282_R	285_K	0.717	1.00
219_P	223_L	0.717	1.00
211_I	257_V	0.716	1.00
8_G	253_G	0.715	1.00
232_L	264_V	0.711	1.00
194_A	198_R	0.709	1.00
200_L	220_V	0.709	1.00
61_G	108_C	0.707	1.00
119_A	249_V	0.702	1.00
213_L	216_E	0.701	1.00
51_E	98_R	0.700	1.00
214_V	221_A	0.697	1.00
15_I	26_R	0.696	1.00
73_G	93_S	0.696	1.00
8_G	132_T	0.693	1.00
286_H	293_R	0.689	1.00
187_F	231_R	0.689	1.00
237_A	271_F	0.688	1.00
108_C	298_L	0.687	1.00
159_P	234_K	0.687	1.00
118_A	285_K	0.685	1.00
161_P	174_V	0.685	1.00
127_A	249_V	0.682	1.00
230_L	270_Q	0.681	1.00
224_A	228_Y	0.679	1.00
287_G	290_S	0.676	1.00
7_L	39_T	0.676	1.00
116_D	286_H	0.675	1.00
40_I	86_Q	0.672	1.00
7_L	12_T	0.672	1.00
77_N	84_N	0.671	1.00
180_K	271_F	0.669	1.00
160_L	235_S	0.669	1.00
260_L	263_T	0.667	1.00
40_I	95_R	0.664	1.00
89_D	102_L	0.664	1.00
200_L	224_A	0.664	1.00
118_A	249_V	0.662	1.00
222_E	259_R	0.662	1.00
194_A	207_G	0.661	1.00
118_A	282_R	0.661	1.00
190_G	194_A	0.660	1.00
5_I	60_V	0.658	1.00
192_G	195_M	0.655	1.00
219_P	222_E	0.654	1.00
152_A	244_D	0.651	1.00
194_A	210_I	0.646	1.00
12_T	29_L	0.645	1.00
46_L	50_A	0.642	1.00
259_R	262_Q	0.639	1.00
230_L	271_F	0.638	1.00
14_V	29_L	0.638	1.00
158_N	235_S	0.637	1.00
233_A	237_A	0.636	1.00
3_I	51_E	0.635	1.00
237_A	268_I	0.632	1.00
228_Y	260_L	0.632	1.00
61_G	299_W	0.631	1.00
32_P	38_Q	0.631	1.00
128_V	136_A	0.626	1.00
259_R	263_T	0.624	1.00
90_K	93_S	0.623	1.00
180_K	183_C	0.622	1.00
38_Q	42_T	0.622	1.00
36_Y	83_L	0.619	1.00
12_T	43_I	0.618	1.00
161_P	173_E	0.618	1.00
113_E	284_A	0.616	1.00
265_G	280_P	0.616	1.00
188_I	228_Y	0.615	1.00
48_D	52_Q	0.615	1.00
160_L	187_F	0.614	1.00
137_G	144_A	0.614	1.00
43_I	92_L	0.611	1.00
198_R	204_A	0.609	1.00
266_Q	269_K	0.607	1.00
42_T	46_L	0.605	1.00
195_M	199_R	0.605	1.00
179_G	183_C	0.603	1.00
237_A	241_N	0.603	1.00
185_E	189_S	0.600	1.00
193_F	224_A	0.597	1.00
159_P	180_K	0.595	1.00
97_Q	100_V	0.595	1.00
229_E	260_L	0.592	1.00
192_G	196_D	0.589	1.00
67_S	78_A	0.589	1.00
176_C	180_K	0.588	1.00
27_H	50_A	0.586	1.00
286_H	290_S	0.586	1.00
176_C	182_G	0.585	1.00
6_D	9_G	0.584	1.00
191_T	195_M	0.581	1.00
193_F	210_I	0.579	1.00
176_C	186_T	0.578	1.00
190_G	254_M	0.578	1.00
145_H	243_L	0.576	1.00
236_L	264_V	0.575	1.00
113_E	286_H	0.575	1.00
50_A	54_T	0.573	1.00
112_S	297_W	0.571	0.99
214_V	229_E	0.571	0.99
210_I	214_V	0.566	0.99
196_D	231_R	0.564	0.99
148_G	244_D	0.564	0.99
293_R	296_A	0.564	0.99
44_A	92_L	0.562	0.99
51_E	57_R	0.559	0.99
109_L	251_G	0.559	0.99
89_D	100_V	0.555	0.99
251_G	284_A	0.552	0.99
9_G	105_D	0.552	0.99
13_E	292_V	0.551	0.99
161_P	231_R	0.550	0.99
113_E	285_K	0.549	0.99
101_R	298_L	0.549	0.99
105_D	129_I	0.547	0.99
224_A	227_R	0.546	0.99
10_T	132_T	0.544	0.99
214_V	217_S	0.544	0.99
135_G	154_E	0.544	0.99
218_D	222_E	0.543	0.99
155_W	242_I	0.543	0.99
171_R	234_K	0.541	0.99
9_G	129_I	0.537	0.99
94_A	97_Q	0.537	0.99
157_H	179_G	0.534	0.99
104_N	107_N	0.533	0.99
117_G	282_R	0.532	0.99
279_T	283_K	0.531	0.99
16_A	57_R	0.531	0.99
76_K	85_G	0.531	0.99
92_L	96_L	0.530	0.99
104_N	135_G	0.530	0.99
127_A	131_G	0.528	0.99
148_G	245_P	0.527	0.99
264_V	268_I	0.526	0.99
222_E	263_T	0.526	0.99
200_L	227_R	0.526	0.99
83_L	86_Q	0.524	0.99
158_N	239_V	0.523	0.99
65_P	79_N	0.520	0.99
140_F	245_P	0.520	0.99
128_V	155_W	0.519	0.99
258_D	265_G	0.519	0.99
104_N	129_I	0.518	0.99
109_L	129_I	0.518	0.99
60_V	92_L	0.517	0.99
67_S	76_K	0.515	0.99
203_H	209_E	0.515	0.99
23_Q	293_R	0.515	0.99
79_N	82_W	0.514	0.99
59_T	101_R	0.513	0.99
70_P	146_I	0.512	0.99
230_L	263_T	0.511	0.99
245_P	248_I	0.511	0.99
70_P	150_G	0.507	0.99
207_G	211_I	0.506	0.99
13_E	190_G	0.506	0.99
31_T	39_T	0.506	0.99
73_G	87_P	0.506	0.99
139_A	144_A	0.506	0.99
130_I	254_M	0.506	0.99
184_I	232_L	0.505	0.99
6_D	253_G	0.505	0.99
160_L	184_I	0.503	0.99
188_I	232_L	0.502	0.99
128_V	239_V	0.502	0.99
117_G	286_H	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1z05A	2	0.9669	100	0.169	Contact Map
2ap1A	2	1	100	0.172	Contact Map
1z6rA	3	0.9669	100	0.179	Contact Map
4db3A	2	0.9702	100	0.185	Contact Map
3vglA	3	0.9636	100	0.187	Contact Map
2yhwA	2	0.9503	100	0.187	Contact Map
3vovA	3	0.957	100	0.188	Contact Map
2qm1A	2	0.9702	100	0.191	Contact Map
4htlA	4	0.9404	100	0.207	Contact Map
2aa4A	2	0.947	100	0.212	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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