GREMLIN Database
MUTS - DNA mismatch repair protein MutS
UniProt: P23909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10625
Length: 853 (810)
Sequences: 4541 (3108)
Seq/√Len: 109.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
582_E643_Q5.9191.00
562_A638_S5.7191.00
580_I583_G5.6281.00
322_L325_Q5.4501.00
326_Q569_C5.0861.00
457_R488_N4.5291.00
96_I109_K4.3411.00
329_G569_C3.9661.00
571_T646_E3.9601.00
430_N523_L3.9431.00
573_I646_E3.8841.00
295_L633_M3.8801.00
579_R646_E3.7801.00
328_I558_L3.6461.00
50_L86_Q3.6371.00
581_T644_K3.5491.00
318_T322_L3.4341.00
631_A650_I3.3381.00
24_H110_V3.1851.00
292_A296_D3.1451.00
651_D685_T3.1151.00
482_S501_Y3.1101.00
558_L638_S3.0921.00
823_S826_V3.0651.00
76_V80_L3.0551.00
435_E512_K3.0391.00
279_I311_L3.0011.00
572_F647_I2.9691.00
412_I415_P2.9561.00
581_T643_Q2.8711.00
405_D409_R2.7701.00
632_L653_I2.7451.00
329_G332_Q2.7391.00
318_T572_F2.7251.00
428_G434_D2.6901.00
601_L627_T2.6791.00
581_T600_P2.6241.00
50_L88_E2.6161.00
274_R279_I2.5661.00
155_F237_A2.5151.00
279_I636_I2.5101.00
325_Q572_F2.5081.00
297_C564_T2.4721.00
453_R505_E2.4511.00
158_S261_E2.4401.00
338_L378_L2.4241.00
318_T574_D2.3521.00
325_Q329_G2.3481.00
46_R88_E2.3471.00
413_D426_A2.3291.00
147_T173_T2.2951.00
579_R602_N2.2841.00
410_A429_Y2.2791.00
630_I640_V2.2741.00
477_I485_A2.2461.00
98_D102_S2.2091.00
28_L39_L2.2021.00
583_G630_I2.2021.00
609_M712_A2.1891.00
431_E435_E2.1881.00
322_L569_C2.1851.00
42_D45_K2.1821.00
269_M273_T2.1771.00
57_K65_P2.1771.00
681_L785_V2.1541.00
608_R741_G2.1341.00
94_E111_V2.1221.00
433_L520_A2.1211.00
406_L534_L2.1131.00
449_R453_R2.1131.00
611_I742_V2.1131.00
504_P508_E2.0981.00
320_V323_E2.0931.00
280_T312_H2.0781.00
310_W555_L2.0741.00
97_G107_E2.0361.00
318_T649_P2.0291.00
739_M742_V2.0251.00
339_Q556_V2.0241.00
329_G639_Y2.0231.00
445_D449_R2.0161.00
373_Q408_E2.0141.00
144_G236_A2.0121.00
582_E600_P2.0071.00
298_T304_S2.0011.00
438_A442_G1.9981.00
398_G541_A1.9951.00
479_R482_S1.9861.00
571_T644_K1.9811.00
610_L745_V1.9761.00
268_I652_R1.9661.00
534_L537_P1.9621.00
411_I531_L1.9611.00
325_Q569_C1.9491.00
331_L338_L1.9451.00
690_V721_A1.9441.00
204_F239_C1.9401.00
335_T563_Y1.9311.00
567_Y633_M1.9241.00
265_D317_D1.9131.00
323_E392_A1.9111.00
716_A739_M1.9021.00
686_E720_K1.9021.00
10_H18_L1.9011.00
134_A170_L1.8941.00
679_N683_N1.8841.00
584_R589_E1.8791.00
612_I724_L1.8751.00
346_G371_A1.8721.00
560_E564_T1.8651.00
15_Q19_R1.8551.00
19_R23_Q1.8381.00
16_Q31_Y1.8331.00
788_R791_Q1.8301.00
579_R644_K1.8201.00
330_A387_S1.8201.00
715_L719_I1.8201.00
310_W554_V1.8131.00
24_H113_I1.8121.00
452_V456_E1.7941.00
134_A173_T1.7911.00
282_N290_T1.7771.00
299_V343_R1.7771.00
526_Q530_E1.7761.00
565_L590_Q1.7731.00
567_Y586_P1.7701.00
538_H541_A1.7651.00
148_L244_A1.7631.00
432_E435_E1.7621.00
134_A147_T1.7621.00
299_V339_Q1.7571.00
558_L636_I1.7561.00
454_E457_R1.7551.00
80_L114_V1.7521.00
306_M554_V1.7511.00
133_L240_L1.7491.00
792_K796_L1.7481.00
454_E489_Y1.7461.00
267_I316_R1.7451.00
713_E788_R1.7401.00
306_M550_A1.7371.00
692_M695_I1.7311.00
583_G626_Q1.7271.00
530_E534_L1.7241.00
128_R304_S1.7221.00
321_L572_F1.7121.00
690_V715_L1.7121.00
315_V320_V1.7021.00
783_K787_K1.6931.00
748_D763_Q1.6881.00
402_E541_A1.6851.00
677_T711_C1.6801.00
30_F76_V1.6781.00
403_L535_L1.6711.00
369_R408_E1.6641.00
475_I489_Y1.6641.00
466_G474_Y1.6611.00
311_L636_I1.6421.00
358_R533_D1.6351.00
142_G159_E1.6331.00
410_A531_L1.6301.00
344_Q374_Q1.6281.00
295_L561_R1.6261.00
788_R792_K1.6191.00
442_G445_D1.6161.00
677_T692_M1.6141.00
481_Q484_L1.6131.00
317_D320_V1.6021.00
210_R214_N1.6001.00
427_S437_R1.5961.00
628_A691_L1.5941.00
325_Q328_I1.5931.00
126_Q129_Q1.5921.00
582_E761_S1.5901.00
169_E172_R1.5891.00
427_S438_A1.5851.00
159_E233_G1.5701.00
366_A369_R1.5681.00
462_T480_G1.5671.00
581_T602_N1.5671.00
211_Q215_L1.5611.00
755_T777_A1.5551.00
444_T517_K1.5491.00
295_L636_I1.5441.00
212_Q245_K1.5421.00
199_R203_E1.5381.00
326_Q329_G1.5261.00
339_Q560_E1.5211.00
577_G646_E1.5191.00
631_A689_L1.5161.00
716_A742_V1.5111.00
478_S481_Q1.4921.00
233_G260_M1.4671.00
39_L69_A1.4661.00
707_L711_C1.4661.00
46_R50_L1.4651.00
457_R489_Y1.4601.00
623_Y762_V1.4581.00
71_I76_V1.4431.00
360_A364_D1.4381.00
716_A741_G1.4351.00
373_Q404_R1.4311.00
583_G601_L1.4311.00
715_L723_T1.4281.00
18_L41_Y1.4251.00
148_L255_I1.4231.00
745_V764_D1.4221.00
453_R457_R1.4151.00
159_E230_A1.4151.00
578_I631_A1.4051.00
743_A764_D1.4031.00
406_L531_L1.4011.00
355_L360_A1.3941.00
128_R296_D1.3911.00
580_I630_I1.3901.00
476_Q498_A1.3881.00
451_E455_R1.3861.00
134_A178_L1.3801.00
39_L47_A1.3771.00
282_N286_G1.3741.00
580_I601_L1.3741.00
774_A790_R1.3691.00
366_A415_P1.3681.00
393_L548_A1.3681.00
746_H763_Q1.3621.00
747_L762_V1.3611.00
47_A53_I1.3611.00
365_L535_L1.3601.00
601_L623_Y1.3561.00
145_Y169_E1.3531.00
135_A179_L1.3461.00
425_I527_L1.3461.00
322_L326_Q1.3421.00
677_T695_I1.3381.00
777_A783_K1.3361.00
318_T325_Q1.3331.00
316_R649_P1.3331.00
369_R407_L1.3311.00
302_M550_A1.3291.00
491_R499_E1.3291.00
533_D537_P1.3220.99
561_R565_L1.3210.99
84_V114_V1.3190.99
341_V378_L1.3130.99
133_L148_L1.3070.99
714_N718_K1.3050.99
297_C561_R1.3010.99
61_S65_P1.2980.99
30_F39_L1.2920.99
635_Y650_I1.2830.99
362_P424_V1.2820.99
138_Q181_A1.2810.99
777_A790_R1.2780.99
345_V371_A1.2720.99
430_N530_E1.2680.99
327_T555_L1.2660.99
322_L571_T1.2640.99
607_R743_A1.2640.99
24_H27_I1.2610.99
28_L47_A1.2600.99
334_F385_V1.2540.99
321_L325_Q1.2510.99
325_Q636_I1.2510.99
266_S313_M1.2510.99
609_M716_A1.2470.99
576_P648_G1.2430.99
502_I507_K1.2430.99
146_A236_A1.2420.99
523_L526_Q1.2390.99
648_G722_L1.2390.99
412_I416_P1.2380.99
607_R764_D1.2290.99
219_T225_F1.2260.99
396_K544_Q1.2210.99
134_A175_P1.2150.99
378_L549_L1.2030.99
335_T560_E1.2010.99
135_A204_F1.2010.99
48_S55_L1.2000.99
183_D201_L1.1940.99
315_V321_L1.1870.99
11_T16_Q1.1840.99
98_D101_T1.1820.99
338_L556_V1.1810.99
462_T481_Q1.1790.99
749_A756_I1.1760.99
290_T293_S1.1740.99
362_P525_K1.1740.99
573_I648_G1.1730.99
23_Q109_K1.1680.99
572_F648_G1.1680.99
28_L46_R1.1650.99
96_I107_E1.1640.99
77_E123_A1.1640.99
460_L477_I1.1600.99
13_M68_M1.1590.99
46_R49_Q1.1580.99
555_L558_L1.1550.99
355_L536_L1.1550.99
97_G102_S1.1540.99
331_L556_V1.1470.99
148_L240_L1.1470.99
824_P827_E1.1460.99
234_L238_G1.1440.98
129_Q308_K1.1420.98
380_A383_E1.1420.98
136_I178_L1.1420.98
57_K61_S1.1410.98
282_N285_G1.1410.98
450_L453_R1.1390.98
230_A233_G1.1390.98
439_L512_K1.1380.98
21_K43_D1.1350.98
16_Q20_L1.1340.98
157_L237_A1.1340.98
396_K551_E1.1330.98
576_P722_L1.1330.98
406_L410_A1.1320.98
22_A25_P1.1320.98
572_F575_K1.1300.98
568_T639_Y1.1300.98
13_M33_M1.1290.98
427_S441_D1.1230.98
566_N643_Q1.1200.98
635_Y649_P1.1190.98
136_I166_M1.1190.98
274_R312_H1.1130.98
276_N283_L1.1120.98
204_F238_G1.1120.98
754_D790_R1.1120.98
341_V374_Q1.1060.98
213_L237_A1.1000.98
138_Q143_F1.0990.98
310_W315_V1.0970.98
600_P761_S1.0940.98
91_A113_I1.0920.98
601_L626_Q1.0910.98
273_T655_T1.0910.98
41_Y66_I1.0910.98
282_N289_N1.0900.98
713_E717_N1.0900.98
27_I113_I1.0890.98
734_Q737_E1.0890.98
398_G402_E1.0860.98
98_D104_G1.0850.98
745_V762_V1.0830.98
736_P742_V1.0830.98
33_M58_R1.0790.98
144_G159_E1.0720.98
371_A549_L1.0690.98
576_P687_Y1.0660.98
582_E598_A1.0660.98
62_A65_P1.0650.98
706_S709_W1.0630.98
433_L527_L1.0620.98
32_R94_E1.0600.98
576_P686_E1.0600.98
685_T688_S1.0580.97
274_R280_T1.0570.97
154_R259_T1.0570.97
84_V119_I1.0550.97
41_Y61_S1.0550.97
267_I653_I1.0530.97
134_A145_Y1.0500.97
30_F71_I1.0450.97
10_H14_M1.0440.97
156_R259_T1.0430.97
306_M310_W1.0400.97
662_D667_R1.0370.97
98_D106_V1.0340.97
57_K62_A1.0330.97
169_E261_E1.0330.97
478_S482_S1.0310.97
508_E512_K1.0300.97
569_C639_Y1.0260.97
325_Q558_L1.0250.97
525_K529_E1.0240.97
450_L454_E1.0230.97
32_R73_Y1.0230.97
322_L572_F1.0220.97
159_E232_R1.0210.97
327_T389_P1.0190.97
325_Q639_Y1.0190.97
20_L110_V1.0190.97
129_Q176_A1.0160.97
38_E70_G1.0150.97
385_V390_V1.0140.97
61_S64_E1.0130.97
280_T292_A1.0120.97
635_Y647_I1.0120.97
29_L93_C1.0080.97
678_A682_H1.0080.97
286_G290_T1.0070.97
375_L549_L1.0050.97
446_Y509_Y1.0040.97
305_R347_D1.0010.96
295_L557_N0.9980.96
335_T556_V0.9980.96
227_V230_A0.9960.96
823_S827_E0.9960.96
819_P823_S0.9940.96
534_L538_H0.9930.96
777_A786_I0.9920.96
214_N219_T0.9890.96
407_L411_I0.9820.96
630_I645_V0.9810.96
406_L411_I0.9810.96
733_T766_A0.9790.96
631_A647_I0.9770.96
59_G65_P0.9760.96
328_I639_Y0.9740.96
528_Y532_F0.9720.96
612_I762_V0.9720.96
222_L225_F0.9650.96
572_F649_P0.9640.96
604_S607_R0.9630.96
267_I636_I0.9620.96
336_A560_E0.9620.96
20_L29_L0.9580.96
432_E519_K0.9560.95
102_S105_P0.9550.95
462_T478_S0.9530.95
13_M31_Y0.9440.95
298_T557_N0.9430.95
610_L623_Y0.9430.95
627_T689_L0.9410.95
10_H41_Y0.9410.95
267_I631_A0.9400.95
230_A260_M0.9400.95
57_K64_E0.9390.95
825_A828_A0.9370.95
265_D320_V0.9370.95
213_L225_F0.9330.95
578_I627_T0.9320.95
310_W551_E0.9310.95
29_L91_A0.9300.95
435_E439_L0.9300.95
577_G604_S0.9300.95
667_R675_T0.9290.95
408_E426_A0.9280.95
270_D652_R0.9270.95
352_L542_L0.9240.95
377_E380_A0.9240.95
352_L539_L0.9230.94
630_I641_P0.9220.94
448_E451_E0.9200.94
142_G232_R0.9190.94
19_R107_E0.9190.94
190_I194_R0.9190.94
119_I125_L0.9170.94
404_R408_E0.9160.94
574_D687_Y0.9130.94
99_P106_V0.9120.94
192_G195_G0.9110.94
366_A370_H0.9100.94
328_I335_T0.9100.94
603_L610_L0.9090.94
684_A719_I0.9080.94
39_L71_I0.9060.94
316_R687_Y0.9050.94
468_N474_Y0.9030.94
424_V525_K0.9030.94
36_F70_G0.9030.94
389_P551_E0.9020.94
144_G233_G0.9010.94
154_R309_R0.9000.94
14_M41_Y0.8990.94
748_D761_S0.8980.94
328_I559_A0.8950.94
130_D154_R0.8940.94
402_E538_H0.8930.93
400_F545_S0.8920.93
223_V228_E0.8920.93
624_M726_A0.8890.93
662_D665_S0.8890.93
158_S169_E0.8890.93
736_P764_D0.8880.93
578_I648_G0.8880.93
179_L239_C0.8880.93
330_A386_D0.8870.93
267_I635_Y0.8860.93
782_P785_V0.8850.93
746_H749_A0.8820.93
267_I632_L0.8770.93
557_N561_R0.8740.93
575_K646_E0.8710.93
702_Y729_Y0.8680.92
706_S710_A0.8660.92
58_R68_M0.8640.92
45_K49_Q0.8630.92
509_Y512_K0.8620.92
746_H766_A0.8620.92
209_A238_G0.8600.92
589_E630_I0.8600.92
325_Q633_M0.8590.92
130_D149_D0.8580.92
210_R228_E0.8580.92
18_L22_A0.8570.92
446_Y450_L0.8540.92
482_S485_A0.8520.92
567_Y589_E0.8510.92
624_M627_T0.8510.92
554_V558_L0.8500.92
281_Q286_G0.8470.92
650_I722_L0.8460.92
781_V785_V0.8450.91
756_I774_A0.8440.91
573_I577_G0.8430.91
578_I647_I0.8420.91
792_K795_E0.8420.91
17_Y33_M0.8410.91
224_G682_H0.8410.91
321_L636_I0.8400.91
266_S315_V0.8390.91
321_L649_P0.8390.91
363_R416_P0.8370.91
640_V645_V0.8370.91
297_C557_N0.8340.91
819_P824_P0.8320.91
648_G687_Y0.8290.91
577_G602_N0.8270.91
42_D46_R0.8250.90
401_A405_D0.8240.90
45_K48_S0.8240.90
572_F634_A0.8240.90
435_E438_A0.8220.90
383_E394_R0.8220.90
402_E405_D0.8220.90
617_M622_T0.8190.90
112_R121_D0.8190.90
19_R22_A0.8180.90
155_F240_L0.8160.90
331_L390_V0.8150.90
469_A496_K0.8140.90
583_G627_T0.8140.90
224_G679_N0.8130.90
471_H496_K0.8120.90
505_E508_E0.8120.90
269_M655_T0.8100.90
138_Q141_K0.8100.90
429_Y530_E0.8100.90
599_N626_Q0.8080.90
311_L633_M0.8070.89
325_Q638_S0.8070.89
157_L258_I0.8060.89
527_L530_E0.8050.89
125_L131_N0.8040.89
10_H62_A0.8040.89
280_T311_L0.8040.89
190_I193_R0.8030.89
80_L92_I0.8020.89
80_L124_L0.8010.89
490_M504_P0.7990.89
460_L485_A0.7960.89
315_V318_T0.7960.89
318_T573_I0.7960.89
439_L450_L0.7950.89
337_G381_Q0.7950.89
102_S107_E0.7930.89
820_E823_S0.7930.89
530_E533_D0.7920.89
289_N293_S0.7910.89
419_V424_V0.7910.89
437_R520_A0.7910.89
791_Q795_E0.7880.88
425_I531_L0.7880.88
751_E769_K0.7870.88
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58_R588_V0.5170.59
566_N589_E0.5170.59
680_I709_W0.5170.59
407_L535_L0.5160.59
35_D40_F0.5160.59
76_V90_V0.5160.59
809_D823_S0.5160.59
219_T222_L0.5150.59
447_L451_E0.5150.59
329_G571_T0.5150.59
617_M701_T0.5150.59
35_D79_Y0.5150.59
633_M638_S0.5140.59
338_L381_Q0.5140.59
93_C290_T0.5140.59
680_I726_A0.5140.59
11_T20_L0.5140.59
267_I644_K0.5140.59
575_K687_Y0.5140.59
81_A124_L0.5140.59
403_L541_A0.5130.59
704_G708_A0.5130.59
32_R35_D0.5120.59
556_V560_E0.5120.59
447_L462_T0.5120.59
627_T630_I0.5120.59
300_T663_L0.5120.59
485_A489_Y0.5120.59
96_I101_T0.5110.59
372_F404_R0.5110.59
29_L110_V0.5100.58
684_A715_L0.5100.58
485_A488_N0.5090.58
624_M628_A0.5090.58
56_T70_G0.5090.58
84_V325_Q0.5090.58
807_Q810_G0.5090.58
379_R383_E0.5080.58
588_V630_I0.5080.58
120_S124_L0.5080.58
471_H502_I0.5070.58
702_Y733_T0.5070.58
609_M721_A0.5070.58
46_R629_L0.5070.58
526_Q740_E0.5070.58
285_G290_T0.5070.58
120_S357_L0.5070.58
769_K774_A0.5070.58
16_Q21_K0.5060.58
132_L183_D0.5060.58
500_R758_F0.5060.58
267_I650_I0.5060.58
331_L383_E0.5060.58
158_S647_I0.5050.58
381_Q384_T0.5050.58
136_I381_Q0.5050.58
476_Q500_R0.5050.58
751_E756_I0.5050.58
170_L178_L0.5040.58
445_D828_A0.5040.58
450_L475_I0.5040.58
551_E554_V0.5030.57
330_A389_P0.5030.57
33_M66_I0.5030.57
191_E194_R0.5010.57
527_L533_D0.5010.57
302_M546_A0.5010.57
318_T635_Y0.5010.57
646_E687_Y0.5000.57
310_W502_I0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.9261 100 0.226 Contact Map
3thxA 1 0.9332 100 0.256 Contact Map
2o8bB 1 0.9097 100 0.264 Contact Map
3thxB 1 0.9332 100 0.276 Contact Map
1ewqA 2 0.8781 100 0.287 Contact Map
4hseA 1 0.3177 99.1 0.95 Contact Map
2px0A 4 0.2919 98.8 0.954 Contact Map
4uxhA 3 0.1911 98.7 0.955 Contact Map
2i3bA 1 0.1547 98.7 0.956 Contact Map
2r8rA 1 0.2298 98.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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