ARGE - ECOLI - GREMLIN Contacts

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ARGE - Acetylornithine deacetylase

UniProt:	P23908	Sequences: MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASIGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11286
Length:	383 (348)
Sequences:	29326 (20766)
Seq/√Len:	1113.2

ECOLI - ARGE YGEY DAPE PEPT ABGA PEPD ALLC ABGB
BACSU - YODQ FAPD YQJE PEPT YXEP DAPEL YHAA AMHX YTNL PEPVL ALLC YQJN ROCB
HALSA - Q9HS25
SULSO - Q97Y12 Q97ZB7 CBPX1 Q97V97 LYSK CBPX2 Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
67_S	137_Y	3.453	1.00
188_R	256_C	3.154	1.00
40_A	44_K	3.014	1.00
188_R	258_E	2.906	1.00
40_A	52_V	2.741	1.00
104_K	360_Y	2.724	1.00
208_L	291_G	2.596	1.00
194_G	202_G	2.515	1.00
74_G	135_P	2.511	1.00
126_D	374_T	2.501	1.00
186_A	258_E	2.496	1.00
275_N	279_N	2.490	1.00
189_I	212_A	2.427	1.00
190_Q	292_R	2.424	1.00
279_N	283_A	2.422	1.00
42_W	45_D	2.416	1.00
190_Q	256_C	2.382	1.00
319_K	379_H	2.351	1.00
190_Q	294_T	2.344	1.00
43_F	66_A	2.295	1.00
188_R	294_T	2.243	1.00
186_A	260_H	2.233	1.00
46_L	125_R	2.225	1.00
38_L	42_W	2.220	1.00
209_M	244_I	2.199	1.00
245_H	258_E	2.191	1.00
74_G	137_Y	2.186	1.00
67_S	135_P	2.166	1.00
209_M	257_C	2.157	1.00
186_A	296_D	2.141	1.00
276_G	280_D	2.123	1.00
243_H	260_H	2.056	1.00
126_D	130_T	2.050	1.00
209_M	259_L	2.044	1.00
33_A	37_T	2.011	1.00
211_D	214_G	1.950	1.00
18_T	38_L	1.940	1.00
76_L	162_P	1.911	1.00
210_H	213_I	1.904	1.00
93_R	101_H	1.896	1.00
92_T	358_D	1.893	1.00
42_W	46_L	1.873	1.00
323_A	375_Q	1.824	1.00
13_R	17_A	1.790	1.00
71_G	133_K	1.790	1.00
188_R	296_D	1.769	1.00
93_R	97_T	1.759	1.00
283_A	287_E	1.753	1.00
14_A	17_A	1.745	1.00
94_D	97_T	1.743	1.00
21_I	34_D	1.736	1.00
41_D	45_D	1.719	1.00
212_A	282_L	1.719	1.00
34_D	37_T	1.700	1.00
48_F	68_I	1.696	1.00
21_I	38_L	1.682	1.00
37_T	41_D	1.674	1.00
210_H	214_G	1.652	1.00
152_R	156_E	1.646	1.00
198_D	201_R	1.641	1.00
211_D	289_W	1.634	1.00
38_L	41_D	1.621	1.00
205_A	257_C	1.609	1.00
207_E	217_L	1.604	1.00
40_A	64_M	1.600	1.00
203_V	208_L	1.590	1.00
193_S	255_A	1.588	1.00
277_L	280_D	1.570	1.00
375_Q	378_H	1.563	1.00
36_I	81_T	1.561	1.00
272_N	276_G	1.560	1.00
14_A	38_L	1.553	1.00
125_R	129_V	1.546	1.00
37_T	52_V	1.542	1.00
270_T	273_E	1.536	1.00
338_Q	343_T	1.532	1.00
33_A	62_F	1.527	1.00
215_H	281_A	1.519	1.00
323_A	379_H	1.517	1.00
273_E	277_L	1.506	1.00
246_G	257_C	1.505	1.00
153_Y	156_E	1.502	1.00
14_A	42_W	1.486	1.00
42_W	125_R	1.481	1.00
153_Y	157_T	1.471	1.00
39_L	81_T	1.459	1.00
76_L	139_L	1.455	1.00
315_E	318_E	1.450	1.00
235_P	267_P	1.436	1.00
324_K	375_Q	1.434	1.00
237_P	274_L	1.432	1.00
103_G	364_R	1.432	1.00
119_F	369_T	1.429	1.00
68_I	128_D	1.429	1.00
44_K	52_V	1.415	1.00
41_D	44_K	1.399	1.00
215_H	284_P	1.396	1.00
40_A	50_V	1.395	1.00
44_K	50_V	1.393	1.00
316_V	379_H	1.393	1.00
192_Q	203_V	1.391	1.00
211_D	288_R	1.367	1.00
375_Q	379_H	1.364	1.00
76_L	165_A	1.363	1.00
189_I	209_M	1.356	1.00
223_L	277_L	1.328	1.00
286_S	293_L	1.321	1.00
37_T	40_A	1.321	1.00
276_G	279_N	1.319	1.00
368_P	371_E	1.313	1.00
115_G	366_I	1.291	1.00
185_N	261_M	1.288	1.00
318_E	322_G	1.288	1.00
100_E	363_T	1.284	1.00
187_I	259_L	1.278	1.00
279_N	295_V	1.277	1.00
77_L	120_I	1.266	1.00
367_K	371_E	1.262	1.00
77_L	377_I	1.261	1.00
115_G	361_L	1.257	1.00
79_G	113_M	1.254	1.00
69_G	135_P	1.252	1.00
73_G	163_D	1.247	1.00
130_T	374_T	1.246	1.00
282_L	293_L	1.245	1.00
10_E	14_A	1.218	1.00
280_D	284_P	1.217	1.00
10_E	13_R	1.212	1.00
51_E	67_S	1.208	1.00
316_V	319_K	1.205	1.00
203_V	291_G	1.204	1.00
206_I	246_G	1.201	1.00
364_R	368_P	1.200	1.00
93_R	99_T	1.195	1.00
11_I	122_D	1.194	1.00
130_T	378_H	1.193	1.00
280_D	283_A	1.192	1.00
11_I	42_W	1.192	1.00
183_I	271_L	1.187	1.00
70_Q	133_K	1.174	1.00
189_I	208_L	1.174	1.00
219_L	277_L	1.160	1.00
124_L	138_I	1.154	1.00
345_V	348_P	1.148	1.00
273_E	276_G	1.139	1.00
315_E	319_K	1.129	1.00
206_I	244_I	1.125	1.00
362_E	365_F	1.121	1.00
168_G	373_I	1.121	1.00
20_S	35_L	1.118	1.00
172_S	354_A	1.111	1.00
321_L	324_K	1.106	1.00
104_K	362_E	1.101	1.00
15_L	35_L	1.100	1.00
215_H	218_Q	1.100	1.00
100_E	103_G	1.100	1.00
281_A	285_V	1.099	1.00
267_P	270_T	1.092	1.00
312_Q	316_V	1.080	1.00
214_G	218_Q	1.079	1.00
36_I	64_M	1.076	1.00
74_G	163_D	1.074	1.00
39_L	117_F	1.071	1.00
215_H	285_V	1.068	1.00
20_S	363_T	1.064	1.00
165_A	341_C	1.061	1.00
11_I	125_R	1.059	1.00
213_I	259_L	1.058	1.00
281_A	284_P	1.055	1.00
275_N	300_P	1.053	1.00
73_G	134_K	1.046	1.00
345_V	349_G	1.044	1.00
311_H	315_E	1.044	1.00
320_L	375_Q	1.033	1.00
13_R	100_E	1.028	1.00
68_I	132_L	1.027	1.00
277_L	281_A	1.026	1.00
34_D	38_L	1.024	1.00
19_P	31_S	1.021	1.00
16_I	110_T	1.021	1.00
115_G	170_P	1.020	1.00
241_L	261_M	1.018	1.00
185_N	275_N	1.015	1.00
374_T	378_H	1.010	1.00
48_F	66_A	1.007	1.00
317_V	376_V	1.006	1.00
207_E	213_I	1.000	1.00
87_D	102_D	0.999	1.00
216_I	278_L	0.994	1.00
22_S	38_L	0.988	1.00
31_S	34_D	0.987	1.00
43_F	121_L	0.984	1.00
46_L	128_D	0.980	1.00
63_N	142_A	0.978	1.00
211_D	218_Q	0.978	1.00
283_A	286_S	0.971	1.00
320_L	324_K	0.967	1.00
211_D	215_H	0.967	1.00
284_P	288_R	0.966	1.00
371_E	375_Q	0.966	1.00
249_A	252_R	0.963	1.00
103_G	362_E	0.962	1.00
122_D	125_R	0.962	1.00
361_L	366_I	0.960	1.00
49_N	67_S	0.960	1.00
17_A	97_T	0.955	1.00
250_S	260_H	0.955	1.00
123_A	374_T	0.952	1.00
93_R	96_F	0.951	1.00
120_I	138_I	0.949	1.00
186_A	250_S	0.948	1.00
36_I	40_A	0.948	1.00
213_I	241_L	0.946	1.00
365_F	368_P	0.944	1.00
81_T	140_A	0.943	1.00
319_K	323_A	0.942	1.00
209_M	213_I	0.940	1.00
12_Y	16_I	0.939	1.00
79_G	117_F	0.937	1.00
284_P	287_E	0.937	1.00
126_D	370_R	0.935	1.00
126_D	371_E	0.931	1.00
370_R	374_T	0.930	1.00
307_C	310_N	0.924	1.00
187_I	282_L	0.916	1.00
320_L	379_H	0.914	1.00
312_Q	315_E	0.906	1.00
48_F	124_L	0.894	1.00
187_I	212_A	0.892	1.00
89_G	358_D	0.892	1.00
50_V	66_A	0.890	1.00
65_L	137_Y	0.887	1.00
190_Q	255_A	0.886	1.00
207_E	210_H	0.880	1.00
123_A	373_I	0.879	1.00
272_N	275_N	0.867	1.00
68_I	124_L	0.867	1.00
137_Y	162_P	0.864	1.00
314_V	318_E	0.864	1.00
280_D	287_E	0.863	1.00
211_D	217_L	0.862	1.00
318_E	325_T	0.862	1.00
15_L	118_A	0.860	1.00
14_A	18_T	0.858	1.00
92_T	101_H	0.856	1.00
316_V	320_L	0.853	1.00
50_V	53_Q	0.852	1.00
70_Q	131_K	0.848	1.00
206_I	257_C	0.848	1.00
268_G	272_N	0.844	1.00
81_T	117_F	0.841	1.00
244_I	257_C	0.839	1.00
334_A	343_T	0.839	1.00
36_I	52_V	0.837	1.00
181_G	265_P	0.837	1.00
124_L	128_D	0.836	1.00
152_R	336_F	0.836	1.00
101_H	104_K	0.834	1.00
311_H	314_V	0.832	1.00
166_I	376_V	0.827	1.00
72_A	135_P	0.820	1.00
35_L	81_T	0.817	1.00
208_L	289_W	0.813	1.00
213_I	244_I	0.813	1.00
272_N	300_P	0.808	1.00
174_Q	178_A	0.807	1.00
51_E	65_L	0.805	1.00
22_S	146_T	0.804	1.00
364_R	367_K	0.801	1.00
214_G	217_L	0.799	1.00
183_I	275_N	0.796	1.00
265_P	271_L	0.795	1.00
184_S	262_D	0.792	1.00
366_I	370_R	0.792	1.00
86_F	96_F	0.787	1.00
20_S	114_K	0.784	1.00
46_L	121_L	0.783	1.00
174_Q	326_E	0.782	1.00
207_E	218_Q	0.782	1.00
42_W	121_L	0.780	1.00
119_F	370_R	0.776	1.00
92_T	96_F	0.775	1.00
241_L	259_L	0.771	1.00
72_A	134_K	0.771	1.00
30_Q	34_D	0.771	1.00
123_A	370_R	0.769	1.00
285_V	288_R	0.766	1.00
119_F	373_I	0.766	1.00
302_I	305_Y	0.763	1.00
245_H	248_D	0.763	1.00
101_H	106_Y	0.757	1.00
77_L	123_A	0.756	1.00
165_A	343_T	0.755	1.00
137_Y	161_R	0.753	1.00
319_K	322_G	0.747	1.00
263_I	274_L	0.746	1.00
126_D	129_V	0.743	1.00
269_M	273_E	0.741	1.00
346_L	372_L	0.741	1.00
12_Y	105_L	0.736	1.00
320_L	323_A	0.736	1.00
189_I	259_L	0.733	1.00
271_L	275_N	0.733	1.00
99_T	102_D	0.730	1.00
15_L	122_D	0.729	1.00
119_F	123_A	0.729	1.00
347_G	351_I	0.727	1.00
36_I	62_F	0.727	1.00
271_L	303_P	0.725	1.00
346_L	350_S	0.725	1.00
345_V	350_S	0.721	1.00
48_F	128_D	0.721	1.00
15_L	370_R	0.720	1.00
22_S	117_F	0.718	1.00
224_K	237_P	0.717	1.00
92_T	97_T	0.715	1.00
216_I	239_L	0.714	1.00
113_M	116_F	0.713	1.00
39_L	140_A	0.713	1.00
122_D	370_R	0.713	1.00
175_P	178_A	0.713	1.00
11_I	14_A	0.710	1.00
45_D	125_R	0.709	1.00
125_R	128_D	0.709	1.00
75_L	377_I	0.709	1.00
306_E	309_P	0.708	1.00
16_I	107_G	0.708	1.00
50_V	64_M	0.707	1.00
203_V	290_P	0.703	1.00
13_R	16_I	0.703	1.00
192_Q	356_Q	0.702	1.00
54_P	62_F	0.701	1.00
239_L	263_I	0.698	1.00
74_G	134_K	0.697	1.00
187_I	295_V	0.695	1.00
146_T	149_A	0.694	1.00
89_G	92_T	0.693	1.00
336_F	339_T	0.692	1.00
39_L	121_L	0.692	1.00
372_L	376_V	0.691	1.00
371_E	374_T	0.691	1.00
13_R	105_L	0.691	1.00
336_F	340_L	0.690	1.00
347_G	350_S	0.687	1.00
225_E	234_V	0.686	1.00
75_L	164_C	0.682	1.00
181_G	304_G	0.681	1.00
185_N	278_L	0.681	1.00
64_M	140_A	0.680	1.00
243_H	258_E	0.677	1.00
184_S	250_S	0.673	1.00
194_G	253_I	0.672	1.00
212_A	259_L	0.669	1.00
139_L	154_F	0.669	1.00
217_L	289_W	0.669	1.00
120_I	168_G	0.668	1.00
122_D	126_D	0.668	1.00
137_Y	160_L	0.668	1.00
30_Q	143_D	0.668	1.00
286_S	291_G	0.664	1.00
51_E	159_A	0.661	1.00
222_N	277_L	0.658	1.00
39_L	64_M	0.658	1.00
83_T	96_F	0.657	1.00
268_G	303_P	0.656	1.00
68_I	138_I	0.651	1.00
321_L	372_L	0.651	1.00
303_P	339_T	0.651	1.00
245_H	260_H	0.650	1.00
314_V	317_V	0.650	1.00
204_N	254_C	0.649	1.00
33_A	52_V	0.647	1.00
268_G	339_T	0.647	1.00
285_V	289_W	0.647	1.00
143_D	146_T	0.644	1.00
117_F	140_A	0.642	1.00
205_A	254_C	0.640	1.00
29_D	32_N	0.635	1.00
211_D	285_V	0.634	1.00
71_G	135_P	0.634	1.00
363_T	367_K	0.632	1.00
97_T	108_L	0.631	1.00
350_S	365_F	0.631	1.00
189_I	205_A	0.631	1.00
286_S	292_R	0.629	1.00
63_N	154_F	0.629	1.00
48_F	138_I	0.628	1.00
106_Y	360_Y	0.627	1.00
11_I	118_A	0.624	1.00
167_I	334_A	0.622	1.00
112_D	121_L	0.622	1.00
51_E	54_P	0.622	1.00
207_E	211_D	0.617	1.00
86_F	107_G	0.616	1.00
47_G	50_V	0.616	1.00
167_I	345_V	0.615	1.00
16_I	20_S	0.613	1.00
118_A	122_D	0.611	1.00
317_V	321_L	0.610	1.00
199_P	202_G	0.609	1.00
78_A	139_L	0.608	1.00
178_A	327_V	0.607	1.00
317_V	320_L	0.607	1.00
29_D	146_T	0.606	1.00
70_Q	135_P	0.606	1.00
220_R	239_L	0.604	1.00
324_K	371_E	0.603	1.00
105_L	363_T	0.600	1.00
353_Q	360_Y	0.600	1.00
43_F	48_F	0.599	1.00
119_F	168_G	0.598	1.00
265_P	274_L	0.597	1.00
200_A	225_E	0.596	1.00
353_Q	356_Q	0.595	1.00
349_G	361_L	0.595	1.00
212_A	281_A	0.592	1.00
282_L	295_V	0.590	1.00
245_H	256_C	0.587	1.00
34_D	41_D	0.586	1.00
18_T	22_S	0.586	1.00
328_V	331_C	0.585	1.00
348_P	351_I	0.584	1.00
223_L	273_E	0.584	1.00
348_P	369_T	0.583	1.00
367_K	370_R	0.582	1.00
326_E	332_T	0.582	1.00
247_G	256_C	0.581	1.00
306_E	310_N	0.579	1.00
96_F	99_T	0.579	1.00
207_E	214_G	0.578	1.00
83_T	108_L	0.576	1.00
177_R	325_T	0.576	1.00
52_V	62_F	0.576	1.00
208_L	285_V	0.575	1.00
187_I	261_M	0.573	1.00
301_P	304_G	0.572	1.00
14_A	45_D	0.572	1.00
105_L	110_T	0.571	1.00
145_E	355_H	0.568	1.00
165_A	337_I	0.568	1.00
14_A	125_R	0.567	1.00
196_S	240_N	0.566	1.00
31_S	104_K	0.566	1.00
19_P	23_A	0.566	1.00
176_V	179_H	0.563	1.00
251_N	264_R	0.562	1.00
164_C	342_P	0.561	1.00
176_V	326_E	0.561	1.00
53_Q	157_T	0.559	1.00
123_A	127_V	0.557	1.00
113_M	117_F	0.556	1.00
100_E	105_L	0.556	1.00
316_V	376_V	0.554	1.00
175_P	311_H	0.554	1.00
318_E	323_A	0.554	1.00
13_R	97_T	0.554	1.00
196_S	242_G	0.553	1.00
269_M	272_N	0.553	1.00
313_L	317_V	0.551	1.00
213_I	261_M	0.551	1.00
65_L	139_L	0.550	1.00
176_V	180_K	0.550	1.00
276_G	283_A	0.550	1.00
317_V	344_L	0.549	1.00
156_E	159_A	0.548	1.00
205_A	253_I	0.547	1.00
189_I	282_L	0.546	1.00
154_F	159_A	0.546	1.00
216_I	241_L	0.544	1.00
261_M	278_L	0.542	1.00
32_N	36_I	0.542	1.00
74_G	161_R	0.542	1.00
79_G	120_I	0.541	1.00
32_N	143_D	0.541	1.00
154_F	158_T	0.540	1.00
149_A	153_Y	0.537	1.00
11_I	38_L	0.537	1.00
347_G	352_N	0.535	1.00
208_L	211_D	0.534	1.00
210_H	217_L	0.534	1.00
164_C	313_L	0.533	1.00
30_Q	153_Y	0.533	1.00
44_K	49_N	0.532	1.00
53_Q	65_L	0.531	1.00
196_S	262_D	0.528	1.00
302_I	336_F	0.526	1.00
155_A	340_L	0.525	1.00
180_K	238_T	0.525	1.00
185_N	295_V	0.525	1.00
95_P	99_T	0.524	1.00
224_K	270_T	0.523	1.00
167_I	170_P	0.523	1.00
78_A	141_T	0.522	1.00
139_L	165_A	0.522	1.00
139_L	337_I	0.521	1.00
275_N	298_L	0.521	1.00
107_G	110_T	0.521	1.00
89_G	357_P	0.521	1.00
168_G	348_P	0.519	1.00
67_S	74_G	0.518	1.00
85_P	249_A	0.518	1.00
21_I	96_F	0.516	1.00
112_D	116_F	0.516	1.00
187_I	293_L	0.516	1.00
43_F	124_L	0.516	1.00
215_H	288_R	0.515	1.00
353_Q	358_D	0.515	1.00
341_C	344_L	0.515	1.00
18_T	35_L	0.514	1.00
165_A	169_E	0.514	1.00
212_A	285_V	0.512	1.00
225_E	235_P	0.512	1.00
156_E	340_L	0.512	1.00
313_L	316_V	0.511	1.00
300_P	303_P	0.510	1.00
275_N	301_P	0.506	1.00
73_G	164_C	0.505	1.00
118_A	366_I	0.504	1.00
177_R	306_E	0.503	1.00
143_D	149_A	0.502	1.00
55_V	63_N	0.501	1.00
89_G	93_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pfoA	2	0.9765	100	0.235	Contact Map
1cg2A	4	0.9452	100	0.278	Contact Map
4pqaA	2	0.9269	100	0.278	Contact Map
4mmoA	2	0.9582	100	0.28	Contact Map
3tx8A	2	0.9164	100	0.28	Contact Map
2f7vA	2	0.9138	100	0.282	Contact Map
3iszA	2	0.9164	100	0.283	Contact Map
3ct9A	2	0.8956	100	0.291	Contact Map
3rzaA	2	0.9243	100	0.294	Contact Map
2rb7A	2	0.9112	100	0.296	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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