GREMLIN Database
ARGE - Acetylornithine deacetylase
UniProt: P23908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11286
Length: 383 (348)
Sequences: 29326 (20766)
Seq/√Len: 1113.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_S137_Y3.4531.00
188_R256_C3.1541.00
40_A44_K3.0141.00
188_R258_E2.9061.00
40_A52_V2.7411.00
104_K360_Y2.7241.00
208_L291_G2.5961.00
194_G202_G2.5151.00
74_G135_P2.5111.00
126_D374_T2.5011.00
186_A258_E2.4961.00
275_N279_N2.4901.00
189_I212_A2.4271.00
190_Q292_R2.4241.00
279_N283_A2.4221.00
42_W45_D2.4161.00
190_Q256_C2.3821.00
319_K379_H2.3511.00
190_Q294_T2.3441.00
43_F66_A2.2951.00
188_R294_T2.2431.00
186_A260_H2.2331.00
46_L125_R2.2251.00
38_L42_W2.2201.00
209_M244_I2.1991.00
245_H258_E2.1911.00
74_G137_Y2.1861.00
67_S135_P2.1661.00
209_M257_C2.1571.00
186_A296_D2.1411.00
276_G280_D2.1231.00
243_H260_H2.0561.00
126_D130_T2.0501.00
209_M259_L2.0441.00
33_A37_T2.0111.00
211_D214_G1.9501.00
18_T38_L1.9401.00
76_L162_P1.9111.00
210_H213_I1.9041.00
93_R101_H1.8961.00
92_T358_D1.8931.00
42_W46_L1.8731.00
323_A375_Q1.8241.00
13_R17_A1.7901.00
71_G133_K1.7901.00
188_R296_D1.7691.00
93_R97_T1.7591.00
283_A287_E1.7531.00
14_A17_A1.7451.00
94_D97_T1.7431.00
21_I34_D1.7361.00
41_D45_D1.7191.00
212_A282_L1.7191.00
34_D37_T1.7001.00
48_F68_I1.6961.00
21_I38_L1.6821.00
37_T41_D1.6741.00
210_H214_G1.6521.00
152_R156_E1.6461.00
198_D201_R1.6411.00
211_D289_W1.6341.00
38_L41_D1.6211.00
205_A257_C1.6091.00
207_E217_L1.6041.00
40_A64_M1.6001.00
203_V208_L1.5901.00
193_S255_A1.5881.00
277_L280_D1.5701.00
375_Q378_H1.5631.00
36_I81_T1.5611.00
272_N276_G1.5601.00
14_A38_L1.5531.00
125_R129_V1.5461.00
37_T52_V1.5421.00
270_T273_E1.5361.00
338_Q343_T1.5321.00
33_A62_F1.5271.00
215_H281_A1.5191.00
323_A379_H1.5171.00
273_E277_L1.5061.00
246_G257_C1.5051.00
153_Y156_E1.5021.00
14_A42_W1.4861.00
42_W125_R1.4811.00
153_Y157_T1.4711.00
39_L81_T1.4591.00
76_L139_L1.4551.00
315_E318_E1.4501.00
235_P267_P1.4361.00
324_K375_Q1.4341.00
237_P274_L1.4321.00
103_G364_R1.4321.00
119_F369_T1.4291.00
68_I128_D1.4291.00
44_K52_V1.4151.00
41_D44_K1.3991.00
215_H284_P1.3961.00
40_A50_V1.3951.00
44_K50_V1.3931.00
316_V379_H1.3931.00
192_Q203_V1.3911.00
211_D288_R1.3671.00
375_Q379_H1.3641.00
76_L165_A1.3631.00
189_I209_M1.3561.00
223_L277_L1.3281.00
286_S293_L1.3211.00
37_T40_A1.3211.00
276_G279_N1.3191.00
368_P371_E1.3131.00
115_G366_I1.2911.00
185_N261_M1.2881.00
318_E322_G1.2881.00
100_E363_T1.2841.00
187_I259_L1.2781.00
279_N295_V1.2771.00
77_L120_I1.2661.00
367_K371_E1.2621.00
77_L377_I1.2611.00
115_G361_L1.2571.00
79_G113_M1.2541.00
69_G135_P1.2521.00
73_G163_D1.2471.00
130_T374_T1.2461.00
282_L293_L1.2451.00
10_E14_A1.2181.00
280_D284_P1.2171.00
10_E13_R1.2121.00
51_E67_S1.2081.00
316_V319_K1.2051.00
203_V291_G1.2041.00
206_I246_G1.2011.00
364_R368_P1.2001.00
93_R99_T1.1951.00
11_I122_D1.1941.00
130_T378_H1.1931.00
280_D283_A1.1921.00
11_I42_W1.1921.00
183_I271_L1.1871.00
70_Q133_K1.1741.00
189_I208_L1.1741.00
219_L277_L1.1601.00
124_L138_I1.1541.00
345_V348_P1.1481.00
273_E276_G1.1391.00
315_E319_K1.1291.00
206_I244_I1.1251.00
362_E365_F1.1211.00
168_G373_I1.1211.00
20_S35_L1.1181.00
172_S354_A1.1111.00
321_L324_K1.1061.00
104_K362_E1.1011.00
15_L35_L1.1001.00
215_H218_Q1.1001.00
100_E103_G1.1001.00
281_A285_V1.0991.00
267_P270_T1.0921.00
312_Q316_V1.0801.00
214_G218_Q1.0791.00
36_I64_M1.0761.00
74_G163_D1.0741.00
39_L117_F1.0711.00
215_H285_V1.0681.00
20_S363_T1.0641.00
165_A341_C1.0611.00
11_I125_R1.0591.00
213_I259_L1.0581.00
281_A284_P1.0551.00
275_N300_P1.0531.00
73_G134_K1.0461.00
345_V349_G1.0441.00
311_H315_E1.0441.00
320_L375_Q1.0331.00
13_R100_E1.0281.00
68_I132_L1.0271.00
277_L281_A1.0261.00
34_D38_L1.0241.00
19_P31_S1.0211.00
16_I110_T1.0211.00
115_G170_P1.0201.00
241_L261_M1.0181.00
185_N275_N1.0151.00
374_T378_H1.0101.00
48_F66_A1.0071.00
317_V376_V1.0061.00
207_E213_I1.0001.00
87_D102_D0.9991.00
216_I278_L0.9941.00
22_S38_L0.9881.00
31_S34_D0.9871.00
43_F121_L0.9841.00
46_L128_D0.9801.00
63_N142_A0.9781.00
211_D218_Q0.9781.00
283_A286_S0.9711.00
320_L324_K0.9671.00
211_D215_H0.9671.00
284_P288_R0.9661.00
371_E375_Q0.9661.00
249_A252_R0.9631.00
103_G362_E0.9621.00
122_D125_R0.9621.00
361_L366_I0.9601.00
49_N67_S0.9601.00
17_A97_T0.9551.00
250_S260_H0.9551.00
123_A374_T0.9521.00
93_R96_F0.9511.00
120_I138_I0.9491.00
186_A250_S0.9481.00
36_I40_A0.9481.00
213_I241_L0.9461.00
365_F368_P0.9441.00
81_T140_A0.9431.00
319_K323_A0.9421.00
209_M213_I0.9401.00
12_Y16_I0.9391.00
79_G117_F0.9371.00
284_P287_E0.9371.00
126_D370_R0.9351.00
126_D371_E0.9311.00
370_R374_T0.9301.00
307_C310_N0.9241.00
187_I282_L0.9161.00
320_L379_H0.9141.00
312_Q315_E0.9061.00
48_F124_L0.8941.00
187_I212_A0.8921.00
89_G358_D0.8921.00
50_V66_A0.8901.00
65_L137_Y0.8871.00
190_Q255_A0.8861.00
207_E210_H0.8801.00
123_A373_I0.8791.00
272_N275_N0.8671.00
68_I124_L0.8671.00
137_Y162_P0.8641.00
314_V318_E0.8641.00
280_D287_E0.8631.00
211_D217_L0.8621.00
318_E325_T0.8621.00
15_L118_A0.8601.00
14_A18_T0.8581.00
92_T101_H0.8561.00
316_V320_L0.8531.00
50_V53_Q0.8521.00
70_Q131_K0.8481.00
206_I257_C0.8481.00
268_G272_N0.8441.00
81_T117_F0.8411.00
244_I257_C0.8391.00
334_A343_T0.8391.00
36_I52_V0.8371.00
181_G265_P0.8371.00
124_L128_D0.8361.00
152_R336_F0.8361.00
101_H104_K0.8341.00
311_H314_V0.8321.00
166_I376_V0.8271.00
72_A135_P0.8201.00
35_L81_T0.8171.00
208_L289_W0.8131.00
213_I244_I0.8131.00
272_N300_P0.8081.00
174_Q178_A0.8071.00
51_E65_L0.8051.00
22_S146_T0.8041.00
364_R367_K0.8011.00
214_G217_L0.7991.00
183_I275_N0.7961.00
265_P271_L0.7951.00
184_S262_D0.7921.00
366_I370_R0.7921.00
86_F96_F0.7871.00
20_S114_K0.7841.00
46_L121_L0.7831.00
174_Q326_E0.7821.00
207_E218_Q0.7821.00
42_W121_L0.7801.00
119_F370_R0.7761.00
92_T96_F0.7751.00
241_L259_L0.7711.00
72_A134_K0.7711.00
30_Q34_D0.7711.00
123_A370_R0.7691.00
285_V288_R0.7661.00
119_F373_I0.7661.00
302_I305_Y0.7631.00
245_H248_D0.7631.00
101_H106_Y0.7571.00
77_L123_A0.7561.00
165_A343_T0.7551.00
137_Y161_R0.7531.00
319_K322_G0.7471.00
263_I274_L0.7461.00
126_D129_V0.7431.00
269_M273_E0.7411.00
346_L372_L0.7411.00
12_Y105_L0.7361.00
320_L323_A0.7361.00
189_I259_L0.7331.00
271_L275_N0.7331.00
99_T102_D0.7301.00
15_L122_D0.7291.00
119_F123_A0.7291.00
347_G351_I0.7271.00
36_I62_F0.7271.00
271_L303_P0.7251.00
346_L350_S0.7251.00
345_V350_S0.7211.00
48_F128_D0.7211.00
15_L370_R0.7201.00
22_S117_F0.7181.00
224_K237_P0.7171.00
92_T97_T0.7151.00
216_I239_L0.7141.00
113_M116_F0.7131.00
39_L140_A0.7131.00
122_D370_R0.7131.00
175_P178_A0.7131.00
11_I14_A0.7101.00
45_D125_R0.7091.00
125_R128_D0.7091.00
75_L377_I0.7091.00
306_E309_P0.7081.00
16_I107_G0.7081.00
50_V64_M0.7071.00
203_V290_P0.7031.00
13_R16_I0.7031.00
192_Q356_Q0.7021.00
54_P62_F0.7011.00
239_L263_I0.6981.00
74_G134_K0.6971.00
187_I295_V0.6951.00
146_T149_A0.6941.00
89_G92_T0.6931.00
336_F339_T0.6921.00
39_L121_L0.6921.00
372_L376_V0.6911.00
371_E374_T0.6911.00
13_R105_L0.6911.00
336_F340_L0.6901.00
347_G350_S0.6871.00
225_E234_V0.6861.00
75_L164_C0.6821.00
181_G304_G0.6811.00
185_N278_L0.6811.00
64_M140_A0.6801.00
243_H258_E0.6771.00
184_S250_S0.6731.00
194_G253_I0.6721.00
212_A259_L0.6691.00
139_L154_F0.6691.00
217_L289_W0.6691.00
120_I168_G0.6681.00
122_D126_D0.6681.00
137_Y160_L0.6681.00
30_Q143_D0.6681.00
286_S291_G0.6641.00
51_E159_A0.6611.00
222_N277_L0.6581.00
39_L64_M0.6581.00
83_T96_F0.6571.00
268_G303_P0.6561.00
68_I138_I0.6511.00
321_L372_L0.6511.00
303_P339_T0.6511.00
245_H260_H0.6501.00
314_V317_V0.6501.00
204_N254_C0.6491.00
33_A52_V0.6471.00
268_G339_T0.6471.00
285_V289_W0.6471.00
143_D146_T0.6441.00
117_F140_A0.6421.00
205_A254_C0.6401.00
29_D32_N0.6351.00
211_D285_V0.6341.00
71_G135_P0.6341.00
363_T367_K0.6321.00
97_T108_L0.6311.00
350_S365_F0.6311.00
189_I205_A0.6311.00
286_S292_R0.6291.00
63_N154_F0.6291.00
48_F138_I0.6281.00
106_Y360_Y0.6271.00
11_I118_A0.6241.00
167_I334_A0.6221.00
112_D121_L0.6221.00
51_E54_P0.6221.00
207_E211_D0.6171.00
86_F107_G0.6161.00
47_G50_V0.6161.00
167_I345_V0.6151.00
16_I20_S0.6131.00
118_A122_D0.6111.00
317_V321_L0.6101.00
199_P202_G0.6091.00
78_A139_L0.6081.00
178_A327_V0.6071.00
317_V320_L0.6071.00
29_D146_T0.6061.00
70_Q135_P0.6061.00
220_R239_L0.6041.00
324_K371_E0.6031.00
105_L363_T0.6001.00
353_Q360_Y0.6001.00
43_F48_F0.5991.00
119_F168_G0.5981.00
265_P274_L0.5971.00
200_A225_E0.5961.00
353_Q356_Q0.5951.00
349_G361_L0.5951.00
212_A281_A0.5921.00
282_L295_V0.5901.00
245_H256_C0.5871.00
34_D41_D0.5861.00
18_T22_S0.5861.00
328_V331_C0.5851.00
348_P351_I0.5841.00
223_L273_E0.5841.00
348_P369_T0.5831.00
367_K370_R0.5821.00
326_E332_T0.5821.00
247_G256_C0.5811.00
306_E310_N0.5791.00
96_F99_T0.5791.00
207_E214_G0.5781.00
83_T108_L0.5761.00
177_R325_T0.5761.00
52_V62_F0.5761.00
208_L285_V0.5751.00
187_I261_M0.5731.00
301_P304_G0.5721.00
14_A45_D0.5721.00
105_L110_T0.5711.00
145_E355_H0.5681.00
165_A337_I0.5681.00
14_A125_R0.5671.00
196_S240_N0.5661.00
31_S104_K0.5661.00
19_P23_A0.5661.00
176_V179_H0.5631.00
251_N264_R0.5621.00
164_C342_P0.5611.00
176_V326_E0.5611.00
53_Q157_T0.5591.00
123_A127_V0.5571.00
113_M117_F0.5561.00
100_E105_L0.5561.00
316_V376_V0.5541.00
175_P311_H0.5541.00
318_E323_A0.5541.00
13_R97_T0.5541.00
196_S242_G0.5531.00
269_M272_N0.5531.00
313_L317_V0.5511.00
213_I261_M0.5511.00
65_L139_L0.5501.00
176_V180_K0.5501.00
276_G283_A0.5501.00
317_V344_L0.5491.00
156_E159_A0.5481.00
205_A253_I0.5471.00
189_I282_L0.5461.00
154_F159_A0.5461.00
216_I241_L0.5441.00
261_M278_L0.5421.00
32_N36_I0.5421.00
74_G161_R0.5421.00
79_G120_I0.5411.00
32_N143_D0.5411.00
154_F158_T0.5401.00
149_A153_Y0.5371.00
11_I38_L0.5371.00
347_G352_N0.5351.00
208_L211_D0.5341.00
210_H217_L0.5341.00
164_C313_L0.5331.00
30_Q153_Y0.5331.00
44_K49_N0.5321.00
53_Q65_L0.5311.00
196_S262_D0.5281.00
302_I336_F0.5261.00
155_A340_L0.5251.00
180_K238_T0.5251.00
185_N295_V0.5251.00
95_P99_T0.5241.00
224_K270_T0.5231.00
167_I170_P0.5231.00
78_A141_T0.5221.00
139_L165_A0.5221.00
139_L337_I0.5211.00
275_N298_L0.5211.00
107_G110_T0.5211.00
89_G357_P0.5211.00
168_G348_P0.5191.00
67_S74_G0.5181.00
85_P249_A0.5181.00
21_I96_F0.5161.00
112_D116_F0.5161.00
187_I293_L0.5161.00
43_F124_L0.5161.00
215_H288_R0.5151.00
353_Q358_D0.5151.00
341_C344_L0.5151.00
18_T35_L0.5141.00
165_A169_E0.5141.00
212_A285_V0.5121.00
225_E235_P0.5121.00
156_E340_L0.5121.00
313_L316_V0.5111.00
300_P303_P0.5101.00
275_N301_P0.5061.00
73_G164_C0.5051.00
118_A366_I0.5041.00
177_R306_E0.5031.00
143_D149_A0.5021.00
55_V63_N0.5011.00
89_G93_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfoA 2 0.9765 100 0.235 Contact Map
1cg2A 4 0.9452 100 0.278 Contact Map
4pqaA 2 0.9269 100 0.278 Contact Map
4mmoA 2 0.9582 100 0.28 Contact Map
3tx8A 2 0.9164 100 0.28 Contact Map
2f7vA 2 0.9138 100 0.282 Contact Map
3iszA 2 0.9164 100 0.283 Contact Map
3ct9A 2 0.8956 100 0.291 Contact Map
3rzaA 2 0.9243 100 0.294 Contact Map
2rb7A 2 0.9112 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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