GREMLIN Database
NLPC - Probable endopeptidase NlpC
UniProt: P23898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11133
Length: 154 (126)
Sequences: 5728 (3973)
Seq/√Len: 353.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_D136_R3.1631.00
79_P88_I2.6461.00
60_V68_V2.5421.00
148_F151_A2.3871.00
42_L126_I2.3621.00
97_L151_A2.3301.00
41_Q74_F2.2441.00
127_H137_S2.1841.00
54_G59_G2.0561.00
89_G152_R2.0271.00
45_W48_T2.0131.00
86_A150_Q1.9591.00
43_Q136_R1.9581.00
66_V118_I1.9521.00
129_S133_G1.9381.00
66_V85_Q1.9061.00
124_Q138_S1.8901.00
102_L116_V1.8291.00
36_A99_P1.8111.00
129_S132_K1.7721.00
91_Q152_R1.7671.00
55_M80_R1.7341.00
81_E84_Q1.6661.00
56_T59_G1.6181.00
113_G149_W1.6131.00
117_G125_F1.6021.00
41_Q45_W1.5691.00
43_Q126_I1.5251.00
35_I39_N1.4991.00
65_F69_T1.4821.00
67_V71_R1.4811.00
62_C115_H1.4481.00
82_T86_A1.4211.00
119_Y123_N1.3541.00
66_V78_L1.3411.00
66_V116_V1.3401.00
48_T134_V1.3101.00
41_Q69_T1.2821.00
86_A113_G1.2801.00
67_V85_Q1.2651.00
105_F117_G1.2551.00
125_F139_L1.2551.00
55_M67_V1.2401.00
41_Q44_S1.2201.00
39_N120_D1.1941.00
129_S135_M1.1841.00
48_T59_G1.1781.00
93_D96_E1.1771.00
38_L74_F1.1751.00
107_T114_L1.1741.00
41_Q73_R1.1681.00
124_Q136_R1.1631.00
70_M78_L1.1611.00
66_V102_L1.1371.00
97_L119_Y1.1201.00
71_R77_Q1.1111.00
67_V80_R1.0991.00
104_F116_V1.0981.00
57_R60_V1.0691.00
94_K97_L1.0681.00
46_H126_I1.0661.00
82_T113_G1.0651.00
84_Q87_S1.0591.00
69_T74_F1.0541.00
105_F125_F1.0331.00
60_V64_G1.0281.00
123_N140_D1.0261.00
115_H127_H0.9821.00
103_V148_F0.9611.00
106_K114_L0.9591.00
45_W68_V0.9511.00
36_A40_D0.9371.00
137_S141_N0.9291.00
130_T133_G0.9271.00
68_V73_R0.9271.00
107_T147_N0.9241.00
49_P59_G0.9231.00
80_R84_Q0.9201.00
126_I136_R0.9171.00
40_D43_Q0.9071.00
48_T56_T0.9041.00
106_K149_W0.9021.00
39_N126_I0.8991.00
132_K135_M0.8911.00
119_Y122_N0.8901.00
38_L70_M0.8841.00
91_Q150_Q0.8681.00
48_T54_G0.8581.00
69_T118_I0.8491.00
106_K112_N0.8421.00
103_V151_A0.8301.00
85_Q116_V0.8241.00
78_L85_Q0.8231.00
108_G114_L0.8201.00
41_Q68_V0.8131.00
94_K145_Q0.8041.00
35_I99_P0.8021.00
52_Y81_E0.8011.00
125_F144_W0.8001.00
50_Y62_C0.7991.00
80_R88_I0.7991.00
38_L69_T0.7961.00
51_R59_G0.7921.00
66_V70_M0.7911.00
43_Q46_H0.7891.00
43_Q120_D0.7861.00
83_K87_S0.7861.00
50_Y128_A0.7691.00
108_G113_G0.7681.00
106_K113_G0.7631.00
97_L103_V0.7551.00
103_V117_G0.7541.00
33_T36_A0.7531.00
45_W60_V0.7511.00
127_H135_M0.7501.00
48_T60_V0.7501.00
60_V134_V0.7491.00
99_P120_D0.7411.00
46_H133_G0.7391.00
89_G92_I0.7381.00
103_V139_L0.7371.00
52_Y64_G0.7361.00
34_V37_G0.7361.00
86_A89_G0.7260.99
106_K111_Q0.7230.99
35_I38_L0.7170.99
142_V146_K0.7150.99
79_P84_Q0.7100.99
39_N42_L0.7050.99
54_G64_G0.6940.99
141_N145_Q0.6870.99
108_G111_Q0.6820.99
42_L118_I0.6700.99
103_V125_F0.6680.99
39_N43_Q0.6590.99
46_H136_R0.6590.99
86_A149_W0.6580.99
94_K148_F0.6580.99
117_G127_H0.6550.99
45_W56_T0.6530.99
65_F126_I0.6510.99
92_I153_R0.6490.99
83_K86_A0.6440.99
31_S34_V0.6360.99
68_V71_R0.6350.99
37_G74_F0.6300.99
25_N30_D0.6220.98
82_T116_V0.6140.98
125_F140_D0.6090.98
140_D145_Q0.6070.98
142_V145_Q0.6060.98
94_K140_D0.6040.98
45_W69_T0.5970.98
94_K151_A0.5920.98
48_T57_R0.5920.98
108_G147_N0.5880.98
125_F137_S0.5860.98
129_S137_S0.5860.98
38_L65_F0.5850.98
64_G67_V0.5810.98
59_G64_G0.5700.97
70_M118_I0.5690.97
55_M64_G0.5670.97
82_T85_Q0.5600.97
120_D124_Q0.5530.97
50_Y115_H0.5430.96
94_K103_V0.5410.96
97_L139_L0.5410.96
97_L148_F0.5400.96
25_N28_L0.5400.96
42_L69_T0.5380.96
26_A29_S0.5360.96
108_G112_N0.5350.96
34_V38_L0.5340.96
86_A104_F0.5330.96
114_L147_N0.5300.96
37_G40_D0.5270.96
30_D34_V0.5240.96
45_W65_F0.5220.95
33_T37_G0.5220.95
70_M76_L0.5140.95
56_T60_V0.5130.95
62_C82_T0.5120.95
67_V77_Q0.5120.95
144_W147_N0.5110.95
64_G128_A0.5110.95
55_M68_V0.5040.95
102_L118_I0.5030.94
121_T124_Q0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k1gA 1 0.7987 100 0.259 Contact Map
3npfA 2 0.974 100 0.275 Contact Map
3h41A 1 0.9935 100 0.279 Contact Map
4hpeA 1 0.961 100 0.282 Contact Map
4q4gX 1 0.9481 100 0.283 Contact Map
4xcmA 2 0.9221 100 0.287 Contact Map
4fdyA 1 0.9221 100 0.293 Contact Map
2hbwA 1 0.9481 100 0.299 Contact Map
3pbiA 1 0.9156 100 0.311 Contact Map
3m1uA 2 0.9545 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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