GREMLIN Database
EMRE - Multidrug transporter EmrE
UniProt: P23895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10629
Length: 110 (102)
Sequences: 4499 (3103)
Seq/√Len: 307.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_G100_I2.8731.00
13_A42_A2.6171.00
49_Q52_A2.5311.00
6_Y49_Q2.3451.00
20_L35_G2.3021.00
76_W83_L2.3021.00
16_I39_C2.1261.00
74_L78_F1.9251.00
72_S91_M1.9061.00
3_P53_Y1.8951.00
11_I66_V1.8681.00
51_L59_A1.7581.00
54_I59_A1.7391.00
93_L97_G1.7271.00
31_W35_G1.6211.00
17_G39_C1.5541.00
45_W49_Q1.5341.00
92_M96_A1.5201.00
85_L89_I1.5181.00
51_L56_T1.4941.00
40_Y44_F1.4871.00
16_I35_G1.4701.00
37_I41_C1.4581.00
27_F33_S1.4431.00
93_L96_A1.4361.00
19_T23_F1.4021.00
90_G104_L1.3761.00
19_T74_L1.3601.00
15_V70_L1.3531.00
21_M36_T1.3531.00
86_P104_L1.3331.00
17_G40_Y1.3231.00
50_T59_A1.3191.00
84_D87_A1.3031.00
6_Y46_L1.2941.00
24_S27_F1.2781.00
13_A39_C1.2711.00
24_S33_S1.2651.00
23_F79_F1.2581.00
90_G97_G1.2551.00
94_I97_G1.2281.00
99_L103_L1.2181.00
88_I92_M1.2081.00
30_L33_S1.2011.00
94_I98_V1.1571.00
29_R32_P1.1431.00
91_M101_I1.1411.00
87_A101_I1.1201.00
47_L59_A1.1081.00
41_C45_W1.0951.00
68_I72_S1.0941.00
16_I20_L1.0851.00
82_R87_A1.0351.00
86_P89_I1.0261.00
4_Y62_I1.0221.00
31_W34_V1.0221.00
83_L88_I1.0201.00
68_I95_C1.0151.00
90_G94_I0.9801.00
83_L87_A0.9751.00
81_Q87_A0.9681.00
8_G66_V0.9641.00
22_K26_G0.9421.00
30_L34_V0.9311.00
69_V91_M0.9281.00
73_L77_G0.9181.00
75_S81_Q0.9171.00
5_I9_G0.9151.00
57_G61_A0.9061.00
20_L23_F0.8911.00
8_G11_I0.8911.00
28_T52_A0.8841.00
96_A100_I0.8781.00
58_I87_A0.8721.00
62_I66_V0.8721.00
25_E29_R0.8651.00
25_E28_T0.8651.00
34_V38_I0.8501.00
90_G93_L0.8431.00
85_L88_I0.8391.00
74_L79_F0.8371.00
9_G46_L0.8101.00
82_R85_L0.8071.00
28_T33_S0.8001.00
61_A64_S0.7830.99
100_I104_L0.7710.99
69_V95_C0.7680.99
15_V74_L0.7660.99
10_A46_L0.7650.99
18_T71_I0.7600.99
28_T32_P0.7590.99
65_G98_V0.7560.99
20_L39_C0.7460.99
19_T79_F0.7430.99
11_I43_S0.7420.99
55_P58_I0.7350.99
3_P6_Y0.7340.99
56_T79_F0.7170.99
20_L36_T0.7170.99
95_C99_L0.7150.99
56_T71_I0.6990.99
86_P90_G0.6930.99
77_G80_G0.6910.99
40_Y64_S0.6850.99
93_L100_I0.6790.99
33_S36_T0.6780.99
3_P50_T0.6720.98
20_L24_S0.6700.98
19_T75_S0.6700.98
49_Q53_Y0.6690.98
26_G32_P0.6650.98
76_W88_I0.6650.98
21_M63_W0.6620.98
3_P54_I0.6580.98
14_E43_S0.6580.98
27_F32_P0.6510.98
89_I93_L0.6480.98
75_S79_F0.6460.98
50_T53_Y0.6440.98
38_I42_A0.6340.98
44_F51_L0.6340.98
40_Y56_T0.6240.98
17_G36_T0.6190.97
81_Q84_D0.6170.97
24_S28_T0.6000.97
66_V70_L0.5980.97
35_G39_C0.5920.97
61_A91_M0.5900.97
64_S75_S0.5890.97
6_Y50_T0.5860.96
12_L70_L0.5850.96
58_I61_A0.5820.96
76_W82_R0.5690.96
24_S29_R0.5660.96
34_V37_I0.5650.96
72_S101_I0.5610.95
7_L59_A0.5600.95
22_K25_E0.5580.95
18_T40_Y0.5520.95
75_S87_A0.5480.95
89_I92_M0.5440.95
10_A47_L0.5390.94
65_G68_I0.5250.94
21_M43_S0.5190.93
11_I98_V0.5190.93
70_L74_L0.5180.93
12_L16_I0.5150.93
7_L50_T0.5070.92
19_T56_T0.5070.92
19_T22_K0.5070.92
82_R104_L0.5060.92
76_W81_Q0.5050.92
24_S36_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.9273 99.9 0.297 Contact Map
2i68A 2 0.7091 99.9 0.346 Contact Map
4o9uB 2 0.7 10.5 0.927 Contact Map
4o93B 1 0.7 6.2 0.934 Contact Map
4pypA 1 0.9909 3.7 0.941 Contact Map
4gx0A 3 0.7545 3.5 0.942 Contact Map
2ls4A 1 0.2182 2.7 0.945 Contact Map
4xnjA 1 0.9727 2.5 0.946 Contact Map
1pw4A 1 0.9545 2.3 0.947 Contact Map
4uisB 1 0.3818 1.8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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