GREMLIN Database
HTPX - Protease HtpX
UniProt: P23894 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10462
Length: 293 (259)
Sequences: 4893 (3598)
Seq/√Len: 223.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_Q287_R4.6271.00
84_T134_E4.4751.00
142_S228_G4.4431.00
100_H122_T4.4271.00
132_E244_R4.3691.00
77_W130_P3.5671.00
138_A229_S3.4571.00
131_D235_R3.2401.00
230_A286_L3.1241.00
120_V137_I3.0081.00
69_Q83_A3.0001.00
223_F281_K2.9011.00
235_R238_M2.7291.00
112_R115_A2.7101.00
227_A231_K2.4821.00
246_K280_D2.4351.00
81_T134_E2.4181.00
79_V93_M2.4111.00
229_S233_V2.3541.00
66_V95_Q2.2021.00
41_L45_G2.1981.00
148_D224_H2.1541.00
89_A232_L2.1331.00
233_V238_M2.1181.00
64_G97_A2.0921.00
281_K284_E2.0641.00
246_K279_L2.0631.00
129_S244_R1.9851.00
243_Q283_I1.9661.00
83_A87_R1.9231.00
236_E239_I1.9081.00
68_E74_R1.8991.00
45_G49_V1.8581.00
278_P281_K1.8321.00
82_V96_V1.8111.00
39_A164_I1.7501.00
18_F22_L1.7471.00
83_A93_M1.7171.00
127_N248_S1.6861.00
211_S215_M1.6441.00
56_W60_R1.6301.00
76_R79_V1.6281.00
227_A285_A1.6111.00
236_E240_A1.6011.00
122_T126_Q1.5941.00
65_E100_H1.5901.00
128_M245_L1.5781.00
284_E288_T1.5781.00
81_T130_P1.5551.00
13_A25_T1.5461.00
116_S144_I1.5321.00
107_F119_A1.5241.00
85_Q141_I1.5171.00
148_D221_R1.5141.00
124_L133_A1.5041.00
147_G150_V1.4791.00
26_G30_S1.4551.00
97_A117_L1.4461.00
66_V97_A1.4311.00
143_H222_E1.3701.00
136_V241_A1.3441.00
108_A118_V1.3391.00
77_W80_N1.3381.00
139_H222_E1.3351.00
271_E281_K1.3301.00
168_R172_Q1.3241.00
69_Q79_V1.3181.00
102_P126_Q1.3181.00
25_T28_Q1.3161.00
285_A288_T1.3101.00
284_E287_R1.3021.00
80_N84_T1.2951.00
223_F285_A1.2751.00
237_K287_R1.2701.00
79_V83_A1.2611.00
146_N228_G1.2561.00
14_V18_F1.2461.00
146_N224_H1.2461.00
65_E74_R1.2441.00
152_M221_R1.2241.00
80_N83_A1.2061.00
75_E98_I1.2031.00
21_V28_Q1.2001.00
178_M181_N1.1951.00
239_I283_I1.1901.00
140_E222_E1.1861.00
10_T14_V1.1741.00
125_L133_A1.1721.00
85_Q232_L1.1541.00
49_V53_M1.1511.00
274_M278_P1.1501.00
220_H224_H1.1421.00
21_V24_L1.1401.00
120_V125_L1.1381.00
91_I141_I1.1361.00
202_L205_V1.1271.00
171_A175_A1.1251.00
224_H228_G1.1221.00
44_F157_G1.1221.00
139_H143_H1.1171.00
131_D237_K1.0841.00
53_M57_M1.0791.00
76_R80_N1.0781.00
280_D284_E1.0771.00
134_E235_R1.0761.00
22_L26_G1.0751.00
235_R239_I1.0661.00
169_I173_L1.0631.00
11_N14_V1.0601.00
69_Q76_R1.0571.00
54_S59_L1.0441.00
59_L107_F1.0411.00
18_F21_V1.0351.00
46_G50_S1.0121.00
62_V99_Y1.0121.00
222_E225_A1.0101.00
224_H227_A0.9991.00
23_S26_G0.9961.00
32_V35_L0.9881.00
191_N196_F0.9861.00
24_L28_Q0.9851.00
218_S275_T0.9781.00
283_I287_R0.9711.00
221_R224_H0.9701.00
193_L196_F0.9551.00
213_I217_F0.9551.00
135_A238_M0.9541.00
98_I125_L0.9531.00
129_S132_E0.9491.00
35_L39_A0.9391.00
10_T17_V0.9381.00
128_M244_R0.9361.00
151_T221_R0.9351.00
234_G237_K0.9341.00
99_Y119_A0.9301.00
139_H225_A0.9251.00
140_E143_H0.9241.00
174_A177_F0.9170.99
189_N192_P0.9140.99
55_K95_Q0.9130.99
19_G23_S0.9130.99
174_A178_M0.9120.99
104_I248_S0.9120.99
78_L120_V0.9110.99
21_V25_T0.9110.99
215_M275_T0.9110.99
281_K285_A0.9110.99
11_N15_M0.9100.99
149_M153_T0.9100.99
111_A115_A0.9100.99
192_P196_F0.9050.99
68_E79_V0.8960.99
10_T13_A0.8930.99
173_L176_G0.8840.99
14_V21_V0.8820.99
36_M40_L0.8770.99
151_T224_H0.8760.99
277_P282_R0.8730.99
84_T88_Q0.8670.99
279_L283_I0.8670.99
104_I127_N0.8620.99
192_P195_Y0.8560.99
27_I30_S0.8550.99
171_A174_A0.8550.99
59_L64_G0.8550.99
234_G238_M0.8540.99
67_I98_I0.8540.99
177_F180_G0.8430.99
254_A261_C0.8400.99
23_S28_Q0.8400.99
68_E76_R0.8390.99
243_Q246_K0.8390.99
48_F52_L0.8370.99
120_V124_L0.8360.99
14_V22_L0.8300.99
91_I145_A0.8300.99
15_M25_T0.8290.99
190_G193_L0.8250.99
131_D238_M0.8250.99
85_Q137_I0.8250.99
170_L174_A0.8250.99
132_E240_A0.8240.99
245_L249_Y0.8230.99
84_T87_R0.8230.99
199_A203_E0.8210.99
75_E78_L0.8150.99
22_L25_T0.8150.99
34_G38_M0.8140.99
142_S232_L0.8110.99
14_V28_Q0.8110.99
192_P198_V0.8070.99
216_W219_R0.8030.99
17_V21_V0.8010.99
165_F169_I0.8010.99
64_G99_Y0.8010.99
237_K240_A0.7980.99
271_E274_M0.7900.98
235_R240_A0.7800.98
67_I78_L0.7780.98
13_A17_V0.7780.98
124_L128_M0.7780.98
16_V20_L0.7760.98
13_A21_V0.7760.98
263_N266_S0.7740.98
80_N130_P0.7730.98
138_A232_L0.7690.98
26_G29_S0.7660.98
69_Q80_N0.7650.98
105_N108_A0.7640.98
31_S35_L0.7640.98
47_S50_S0.7610.98
82_V137_I0.7590.98
196_F200_T0.7570.98
176_G179_G0.7570.98
88_Q234_G0.7510.98
19_G27_I0.7490.98
86_A93_M0.7440.98
86_A141_I0.7390.98
191_N198_V0.7390.98
52_L111_A0.7330.98
205_V209_L0.7330.98
51_L54_S0.7310.97
89_A141_I0.7290.97
112_R116_S0.7270.97
18_F25_T0.7220.97
173_L177_F0.7170.97
53_M56_W0.7160.97
175_A179_G0.7150.97
109_T149_M0.7120.97
99_Y103_D0.7100.97
75_E79_V0.7090.97
165_F168_R0.7080.97
262_I265_K0.7020.97
18_F29_S0.7010.97
25_T29_S0.7000.97
145_A228_G0.6990.97
18_F26_G0.6980.97
141_I144_I0.6900.96
37_I41_L0.6860.96
143_H225_A0.6850.96
86_A92_A0.6830.96
222_E276_H0.6820.96
78_L96_V0.6790.96
155_I217_F0.6780.96
150_V154_L0.6750.96
102_P122_T0.6730.96
23_S27_I0.6720.96
159_V214_T0.6720.96
177_F181_N0.6710.96
172_Q175_A0.6690.96
118_V137_I0.6670.96
175_A178_M0.6670.96
170_L173_L0.6660.96
101_A122_T0.6610.95
62_V100_H0.6600.95
47_S51_L0.6580.95
228_G231_K0.6560.95
14_V17_V0.6530.95
145_A231_K0.6520.95
230_A234_G0.6480.95
43_G47_S0.6480.95
155_I214_T0.6440.95
128_M241_A0.6440.95
128_M133_A0.6440.95
10_T22_L0.6430.95
40_L47_S0.6400.95
240_A283_I0.6330.94
167_S171_A0.6250.94
37_I40_L0.6230.94
176_G180_G0.6230.94
179_G189_N0.6210.94
13_A19_G0.6190.94
95_Q117_L0.6190.94
65_E68_E0.6180.94
130_P134_E0.6170.93
191_N195_Y0.6150.93
128_M136_V0.6150.93
159_V210_A0.6130.93
233_V239_I0.6110.93
34_G37_I0.6100.93
189_N195_Y0.6090.93
13_A18_F0.6080.93
223_F278_P0.6070.93
120_V144_I0.6070.93
230_A235_R0.6060.93
243_Q247_T0.6040.93
270_S274_M0.6000.92
146_N221_R0.5990.92
242_L279_L0.5990.92
229_S240_A0.5980.92
15_M18_F0.5960.92
15_M19_G0.5960.92
239_I287_R0.5950.92
108_A119_A0.5950.92
171_A192_P0.5950.92
49_V57_M0.5940.92
270_S281_K0.5940.92
82_V89_A0.5930.92
24_L27_I0.5930.92
229_S238_M0.5890.92
152_M218_S0.5880.92
16_V19_G0.5860.92
104_I123_G0.5850.92
242_L286_L0.5800.91
208_I211_S0.5800.91
57_M127_N0.5800.91
154_L158_V0.5770.91
202_L206_F0.5750.91
13_A16_V0.5730.91
94_P148_D0.5730.91
99_Y121_S0.5730.91
173_L178_M0.5720.91
80_N87_R0.5710.91
31_S34_G0.5710.91
81_T85_Q0.5700.90
87_R90_G0.5670.90
160_N163_V0.5660.90
81_T84_T0.5650.90
62_V261_C0.5650.90
105_N139_H0.5650.90
210_A213_I0.5640.90
140_E276_H0.5620.90
216_W220_H0.5610.90
93_M96_V0.5610.90
18_F28_Q0.5610.90
78_L125_L0.5600.90
92_A115_A0.5580.90
103_D245_L0.5580.90
67_I75_E0.5530.89
10_T20_L0.5520.89
40_L44_F0.5520.89
135_A242_L0.5510.89
143_H276_H0.5500.89
13_A24_L0.5500.89
56_W59_L0.5490.89
230_A242_L0.5480.89
68_E75_E0.5470.89
101_A104_I0.5450.88
41_L44_F0.5450.88
22_L176_G0.5430.88
85_Q134_E0.5420.88
193_L197_A0.5410.88
108_A121_S0.5400.88
86_A90_G0.5390.88
207_G210_A0.5390.88
70_P76_R0.5370.88
108_A116_S0.5360.88
158_V163_V0.5350.88
210_A286_L0.5340.87
44_F48_F0.5320.87
32_V38_M0.5310.87
172_Q176_G0.5300.87
124_L136_V0.5280.87
56_W114_D0.5280.87
223_F242_L0.5270.87
50_S54_S0.5270.87
66_V137_I0.5270.87
260_L264_G0.5270.87
156_Q160_N0.5260.87
44_F161_T0.5260.87
108_A144_I0.5260.87
188_S191_N0.5240.86
67_I79_V0.5230.86
16_V24_L0.5220.86
226_D282_R0.5220.86
109_T119_A0.5190.86
162_F206_F0.5190.86
228_G232_L0.5190.86
118_V141_I0.5180.86
239_I286_L0.5180.86
109_T117_L0.5150.85
152_M155_I0.5150.85
65_E122_T0.5140.85
162_F213_I0.5100.85
15_M28_Q0.5090.85
149_M152_M0.5080.85
180_G188_S0.5070.85
58_A62_V0.5060.85
17_V22_L0.5060.85
61_S66_V0.5050.84
69_Q74_R0.5050.84
82_V134_E0.5030.84
176_G181_N0.5030.84
245_L263_N0.5030.84
62_V119_A0.5030.84
79_V96_V0.5020.84
245_L279_L0.5000.84
215_M274_M0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.9113 100 0.276 Contact Map
4il3A 1 0.9215 100 0.29 Contact Map
3c37A 1 0.6485 100 0.49 Contact Map
3cqbA 4 0.3618 99.9 0.626 Contact Map
4qhjA 2 0.3481 97.2 0.866 Contact Map
4jixA 2 0.3686 96.7 0.876 Contact Map
4jiuA 1 0.3447 96.2 0.882 Contact Map
3dteA 2 0.5154 93.4 0.9 Contact Map
4o66A 2 0.2321 33.6 0.941 Contact Map
4ev6A 3 0.1911 7.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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