GREMLIN Database
GSA - Glutamate-1-semialdehyde 2,1-aminomutase
UniProt: P23893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10432
Length: 426 (377)
Sequences: 20864 (12479)
Seq/√Len: 642.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_I80_E4.3511.00
224_R228_D4.0591.00
389_E421_R4.0271.00
43_Y51_A3.5791.00
184_L222_G3.4581.00
330_R413_N3.3601.00
98_L313_N3.1851.00
38_K45_Y3.1111.00
247_L253_Y2.8891.00
319_G322_E2.8571.00
330_R409_M2.8191.00
70_A317_Q2.7321.00
341_E420_R2.6621.00
73_N77_E2.6511.00
323_T327_L2.5891.00
408_S411_D2.5621.00
55_Y415_T2.3981.00
98_L316_A2.3761.00
310_A313_N2.3471.00
222_G225_A2.3421.00
334_G416_I2.3031.00
70_A310_A2.2391.00
43_Y411_D2.2121.00
37_E47_V2.2121.00
225_A229_E2.2101.00
70_A314_E2.1971.00
68_H314_E2.1801.00
326_E409_M2.1651.00
385_M388_D2.1211.00
188_R229_E2.1091.00
45_Y51_A2.0401.00
134_K197_E1.9871.00
334_G413_N1.9671.00
342_A420_R1.9611.00
98_L309_F1.9531.00
391_V418_A1.9501.00
95_M308_G1.9281.00
385_M389_E1.8891.00
202_I235_I1.8731.00
72_R76_I1.8441.00
108_M280_R1.8431.00
332_A336_L1.8331.00
329_T333_E1.8241.00
414_N418_A1.8051.00
46_D50_K1.8011.00
280_R284_D1.7891.00
107_D280_R1.7821.00
37_E81_R1.7811.00
90_E94_K1.7781.00
187_V223_L1.7641.00
50_K390_G1.7551.00
314_E318_P1.7521.00
75_V307_A1.7391.00
112_V274_G1.7361.00
188_R192_E1.7221.00
97_Q101_E1.7141.00
201_I227_C1.7011.00
203_V223_L1.6771.00
75_V79_A1.6731.00
43_Y414_N1.6661.00
332_A350_H1.6281.00
334_G337_E1.6221.00
40_D69_P1.6191.00
119_T262_C1.6131.00
342_A424_A1.6001.00
263_L275_A1.5821.00
268_G273_V1.5521.00
346_L360_T1.5481.00
191_F232_A1.5441.00
102_L316_A1.5281.00
271_M304_A1.5221.00
327_L330_R1.5121.00
247_L325_D1.5091.00
138_F219_F1.5081.00
51_A414_N1.5071.00
129_F282_V1.4991.00
185_A189_A1.4981.00
77_E81_R1.4901.00
96_A111_M1.4841.00
42_A411_D1.4831.00
327_L412_I1.4801.00
334_G417_D1.4641.00
218_E221_P1.4541.00
236_I251_Q1.4511.00
98_L101_E1.4471.00
332_A355_F1.4421.00
103_V277_G1.4401.00
385_M422_V1.4261.00
42_A406_A1.4261.00
263_L277_G1.4161.00
136_I198_I1.4151.00
389_E422_V1.4151.00
94_K309_F1.4151.00
247_L252_D1.4101.00
188_R222_G1.3941.00
323_T326_E1.3921.00
135_I200_C1.3901.00
46_D52_Y1.3891.00
336_L339_A1.3871.00
109_V277_G1.3731.00
121_S276_F1.3701.00
224_R234_L1.3681.00
224_R227_C1.3671.00
123_I135_I1.3621.00
386_M393_L1.3571.00
273_V305_M1.3521.00
310_A314_E1.3511.00
192_E230_F1.3491.00
309_F313_N1.3441.00
36_I44_L1.3431.00
69_P73_N1.3311.00
267_I273_V1.3231.00
330_R334_G1.3221.00
122_A262_C1.3161.00
189_A193_Q1.3011.00
126_A235_I1.2991.00
203_V220_L1.2991.00
334_G420_R1.2981.00
407_H412_I1.2971.00
94_K313_N1.2961.00
248_A252_D1.2961.00
100_T109_V1.2921.00
129_F285_A1.2921.00
40_D67_N1.2861.00
180_T186_S1.2861.00
101_E316_A1.2851.00
322_E326_E1.2841.00
68_H318_P1.2821.00
218_E254_Y1.2801.00
338_A416_I1.2751.00
201_I223_L1.2671.00
251_Q261_T1.2591.00
182_N216_L1.2591.00
327_L409_M1.2581.00
338_A420_R1.2511.00
119_T202_I1.2491.00
260_L278_G1.2481.00
38_K81_R1.2401.00
134_K177_L1.2321.00
267_I275_A1.2211.00
185_A188_R1.2171.00
273_V308_G1.2151.00
67_N72_R1.2151.00
112_V276_F1.2141.00
254_Y351_V1.2131.00
75_V303_I1.2101.00
236_I256_V1.2081.00
420_R424_A1.2051.00
73_N76_I1.2051.00
74_A310_A1.2031.00
184_L226_L1.1981.00
313_N317_Q1.1861.00
108_M284_D1.1851.00
253_Y351_V1.1731.00
64_L314_E1.1721.00
221_P225_A1.1671.00
386_M418_A1.1611.00
72_R80_E1.1581.00
72_R79_A1.1531.00
257_V279_R1.1511.00
411_D414_N1.1491.00
152_K202_I1.1451.00
132_R231_G1.1401.00
417_D421_R1.1381.00
176_T179_C1.1351.00
76_I79_A1.1261.00
105_T257_V1.1051.00
111_M305_M1.1031.00
391_V415_T1.0971.00
188_R226_L1.0961.00
43_Y53_I1.0961.00
389_E418_A1.0951.00
386_M422_V1.0921.00
260_L276_F1.0901.00
40_D51_A1.0851.00
325_D329_T1.0731.00
116_T149_L1.0721.00
386_M391_V1.0671.00
37_E90_E1.0651.00
233_L282_V1.0631.00
409_M413_N1.0611.00
180_T183_D1.0581.00
42_A53_I1.0561.00
249_G263_L1.0541.00
333_E337_E1.0461.00
227_C232_A1.0451.00
123_I152_K1.0411.00
221_P255_G1.0371.00
314_E317_Q1.0331.00
188_R225_A1.0311.00
269_G311_C1.0291.00
95_M309_F1.0251.00
321_H324_L1.0241.00
414_N417_D1.0221.00
188_R230_F1.0151.00
206_V351_V1.0151.00
125_L276_F1.0041.00
171_D174_K1.0031.00
413_N417_D1.0031.00
71_I307_A0.9931.00
246_A252_D0.9861.00
183_D186_S0.9791.00
37_E49_G0.9761.00
137_K202_I0.9681.00
118_A262_C0.9651.00
64_L311_C0.9631.00
177_L346_L0.9601.00
384_H388_D0.9481.00
40_D45_Y0.9471.00
63_V266_I0.9461.00
138_F215_P0.9461.00
410_E413_N0.9381.00
37_E45_Y0.9351.00
223_L234_L0.9351.00
315_V321_H0.9331.00
102_L248_A0.9331.00
323_T409_M0.9321.00
315_V320_V0.9301.00
243_F315_V0.9291.00
225_A228_D0.9291.00
98_L102_L0.9261.00
220_L254_Y0.9211.00
53_I411_D0.9201.00
205_P236_I0.9181.00
62_M269_G0.9171.00
306_A310_A0.9131.00
179_C183_D0.9121.00
73_N80_E0.9111.00
339_A345_P0.9081.00
346_L358_F0.9081.00
106_M277_G0.9081.00
186_S189_A0.9031.00
134_K198_I0.9031.00
200_C235_I0.9021.00
133_D197_E0.9021.00
217_P221_P0.9011.00
191_F198_I0.8941.00
172_F186_S0.8941.00
320_V324_L0.8931.00
70_A313_N0.8911.00
70_A73_N0.8861.00
322_E325_D0.8831.00
179_C190_A0.8831.00
214_P351_V0.8711.00
226_L230_F0.8681.00
139_E180_T0.8671.00
116_T146_A0.8621.00
42_A408_S0.8601.00
134_K192_E0.8601.00
55_Y407_H0.8591.00
195_P230_F0.8591.00
171_D175_Y0.8571.00
129_F233_L0.8521.00
77_E80_E0.8521.00
64_L71_I0.8511.00
102_L312_L0.8471.00
125_L278_G0.8461.00
122_A235_I0.8421.00
231_G281_D0.8401.00
126_A233_L0.8381.00
253_Y325_D0.8371.00
113_N117_E0.8371.00
218_E222_G0.8371.00
53_I414_N0.8361.00
77_E306_A0.8331.00
347_V358_F0.8271.00
336_L340_E0.8271.00
151_V165_S0.8261.00
126_A200_C0.8241.00
271_M303_I0.8231.00
35_F93_V0.8221.00
341_E424_A0.8211.00
104_P251_Q0.8211.00
354_M402_F0.8201.00
353_G407_H0.8191.00
328_T332_A0.8191.00
407_H415_T0.8191.00
100_T106_M0.8151.00
334_G412_I0.8131.00
338_A342_A0.8101.00
105_T261_T0.8081.00
55_Y391_V0.8051.00
333_E336_L0.8041.00
228_D257_V0.8031.00
241_T354_M0.8001.00
35_F47_V0.7991.00
243_F312_L0.7981.00
47_V90_E0.7971.00
359_F382_F0.7961.00
248_A321_H0.7961.00
94_K98_L0.7931.00
321_H325_D0.7921.00
337_E341_E0.7911.00
224_R256_V0.7891.00
381_R385_M0.7891.00
42_A404_S0.7861.00
362_A365_V0.7851.00
70_A74_A0.7851.00
296_G299_S0.7801.00
82_G85_F0.7741.00
53_I415_T0.7701.00
128_G293_Y0.7681.00
99_V277_G0.7681.00
41_G406_A0.7671.00
60_G402_F0.7651.00
134_K194_Y0.7651.00
251_Q256_V0.7651.00
337_E340_E0.7631.00
401_G419_A0.7621.00
243_F267_I0.7581.00
109_V275_A0.7571.00
95_M305_M0.7571.00
201_I232_A0.7501.00
227_C234_L0.7481.00
186_S190_A0.7471.00
337_E420_R0.7461.00
349_N358_F0.7461.00
112_V118_A0.7451.00
330_R333_E0.7421.00
71_I269_G0.7421.00
249_G261_T0.7411.00
114_S117_E0.7411.00
74_A307_A0.7391.00
131_G197_E0.7391.00
91_M306_A0.7381.00
124_R294_Q0.7341.00
191_F226_L0.7341.00
228_D234_L0.7311.00
123_I202_I0.7301.00
198_I232_A0.7291.00
126_A260_L0.7291.00
382_F419_A0.7281.00
56_V394_A0.7281.00
36_I39_A0.7281.00
92_E96_A0.7251.00
57_G402_F0.7251.00
214_P350_H0.7241.00
248_A316_A0.7241.00
326_E330_R0.7221.00
205_P220_L0.7221.00
187_V201_I0.7211.00
215_P218_E0.7201.00
181_Y215_P0.7191.00
243_F263_L0.7181.00
348_V355_F0.7181.00
222_G226_L0.7171.00
245_V253_Y0.7131.00
281_D284_D0.7091.00
89_T92_E0.7091.00
162_Q165_S0.7041.00
91_M309_F0.7041.00
208_G240_M0.7041.00
175_Y178_T0.7011.00
326_E329_T0.7001.00
243_F248_A0.7001.00
263_L267_I0.6991.00
264_G274_G0.6991.00
88_P93_V0.6981.00
91_M305_M0.6971.00
324_L328_T0.6961.00
415_T418_A0.6941.00
98_L312_L0.6921.00
148_C165_S0.6921.00
44_L392_Y0.6921.00
125_L286_L0.6891.00
50_K388_D0.6891.00
208_G354_M0.6881.00
142_Y145_H0.6871.00
106_M261_T0.6861.00
327_L353_G0.6851.00
350_H355_F0.6831.00
383_F395_P0.6831.00
190_A193_Q0.6831.00
93_V97_Q0.6811.00
79_A303_I0.6801.00
67_N79_A0.6801.00
176_T183_D0.6791.00
234_L256_V0.6771.00
328_T350_H0.6761.00
119_T149_L0.6751.00
121_S294_Q0.6751.00
91_M95_M0.6751.00
382_F422_V0.6691.00
221_P254_Y0.6671.00
410_E414_N0.6671.00
203_V234_L0.6631.00
64_L320_V0.6631.00
278_G283_M0.6631.00
348_V357_I0.6621.00
206_V245_V0.6621.00
53_I391_V0.6561.00
190_A194_Y0.6551.00
287_A293_Y0.6541.00
194_Y197_E0.6521.00
81_R90_E0.6491.00
103_V261_T0.6491.00
339_A347_V0.6481.00
239_V262_C0.6481.00
207_A210_M0.6441.00
359_F423_F0.6431.00
235_I260_L0.6431.00
339_A348_V0.6431.00
386_M419_A0.6391.00
95_M273_V0.6391.00
327_L407_H0.6381.00
152_K176_T0.6381.00
129_F281_D0.6371.00
330_R412_I0.6371.00
382_F386_M0.6361.00
91_M94_K0.6351.00
164_N167_G0.6331.00
174_K178_T0.6321.00
342_A423_F0.6321.00
122_A260_L0.6311.00
331_L416_I0.6291.00
179_C186_S0.6281.00
132_R232_A0.6281.00
401_G415_T0.6271.00
220_L236_I0.6271.00
102_L249_G0.6261.00
282_V285_A0.6231.00
323_T408_S0.6231.00
56_V392_Y0.6221.00
217_P351_V0.6201.00
78_A81_R0.6191.00
78_A91_M0.6181.00
323_T412_I0.6181.00
357_I419_A0.6181.00
136_I187_V0.6161.00
243_F249_G0.6151.00
125_L260_L0.6151.00
279_R282_V0.6141.00
416_I420_R0.6131.00
380_K384_H0.6091.00
83_L271_M0.6091.00
57_G404_S0.6081.00
42_A407_H0.6081.00
217_P254_Y0.6071.00
187_V222_G0.6071.00
177_L190_A0.6071.00
35_F88_P0.6071.00
82_G86_G0.6071.00
39_A44_L0.6061.00
189_A192_E0.6031.00
331_L355_F0.6021.00
207_A213_V0.6011.00
103_V249_G0.6001.00
79_A307_A0.5981.00
391_V414_N0.5961.00
136_I190_A0.5961.00
74_A77_E0.5951.00
251_Q258_P0.5951.00
191_F230_F0.5931.00
105_T251_Q0.5921.00
115_G239_V0.5921.00
324_L405_V0.5911.00
104_P252_D0.5901.00
327_L408_S0.5891.00
63_V405_V0.5891.00
51_A418_A0.5891.00
100_T107_D0.5871.00
130_T199_A0.5861.00
329_T332_A0.5831.00
264_G298_L0.5831.00
127_R147_D0.5821.00
184_L187_V0.5821.00
307_A310_A0.5811.00
112_V117_E0.5811.00
205_P251_Q0.5811.00
187_V226_L0.5791.00
360_T363_E0.5771.00
357_I401_G0.5761.00
103_V263_L0.5741.00
418_A422_V0.5721.00
37_E40_D0.5711.00
71_I310_A0.5701.00
138_F223_L0.5701.00
344_I360_T0.5681.00
228_D281_D0.5681.00
71_I311_C0.5681.00
331_L412_I0.5661.00
102_L247_L0.5651.00
407_H411_D0.5651.00
324_L353_G0.5621.00
361_D365_V0.5611.00
418_A421_R0.5611.00
345_P357_I0.5571.00
240_M400_A0.5561.00
172_F175_Y0.5561.00
419_A423_F0.5561.00
383_F387_L0.5541.00
248_A312_L0.5521.00
123_I148_C0.5511.00
184_L188_R0.5511.00
132_R197_E0.5501.00
205_P241_T0.5491.00
384_H387_L0.5481.00
137_K178_T0.5481.00
105_T279_R0.5451.00
191_F194_Y0.5441.00
95_M111_M0.5441.00
138_F179_C0.5441.00
145_H295_A0.5441.00
38_K51_A0.5431.00
260_L282_V0.5431.00
394_A397_A0.5421.00
138_F203_V0.5401.00
226_L229_E0.5391.00
406_A411_D0.5391.00
74_A313_N0.5381.00
209_N400_A0.5381.00
240_M354_M0.5381.00
248_A315_V0.5370.99
349_N356_G0.5360.99
179_C182_N0.5360.99
39_A62_M0.5340.99
53_I407_H0.5340.99
415_T419_A0.5330.99
330_R416_I0.5320.99
103_V109_V0.5320.99
334_G338_A0.5310.99
185_A222_G0.5310.99
100_T103_V0.5300.99
81_R91_M0.5300.99
171_D190_A0.5300.99
58_S84_S0.5290.99
72_R269_G0.5280.99
87_A392_Y0.5280.99
40_D43_Y0.5280.99
192_E229_E0.5280.99
345_P423_F0.5270.99
201_I228_D0.5270.99
412_I415_T0.5260.99
34_L37_E0.5260.99
133_D167_G0.5250.99
64_L68_H0.5240.99
100_T277_G0.5240.99
316_A319_G0.5240.99
361_D364_S0.5240.99
36_I87_A0.5240.99
75_V271_M0.5230.99
309_F316_A0.5210.99
312_L316_A0.5190.99
238_E250_A0.5170.99
104_P107_D0.5170.99
94_K97_Q0.5150.99
301_N304_A0.5130.99
331_L334_G0.5120.99
69_P80_E0.5120.99
214_P254_Y0.5120.99
413_N416_I0.5110.99
381_R384_H0.5100.99
391_V422_V0.5070.99
390_G418_A0.5060.99
171_D187_V0.5060.99
223_L232_A0.5060.99
184_L223_L0.5040.99
32_T387_L0.5040.99
261_T277_G0.5030.99
339_A423_F0.5030.99
71_I314_E0.5030.99
258_P261_T0.5010.99
77_E310_A0.5010.99
320_V323_T0.5010.99
233_L260_L0.5000.99
412_I416_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2epjA 2 0.9742 100 0.358 Contact Map
4e77A 2 0.9531 100 0.371 Contact Map
4atqA 7 0.9554 100 0.392 Contact Map
2ykyA 4 0.9507 100 0.394 Contact Map
4ao9A 2 0.9484 100 0.399 Contact Map
4e3qA 3 0.9789 100 0.4 Contact Map
4a0gA 2 0.9601 100 0.4 Contact Map
3oksA 2 0.9624 100 0.405 Contact Map
4uoxA 3 0.946 100 0.409 Contact Map
4ffcA 4 0.9507 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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