GREMLIN Database
CADC - Transcriptional activator CadC
UniProt: P23890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10133
Length: 512 (423)
Sequences: 1348 (1249)
Seq/√Len: 60.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
432_K435_E7.3351.00
465_M468_E6.6371.00
457_G473_Y4.7911.00
424_A440_I4.6701.00
388_S399_A3.7721.00
39_F53_L3.2901.00
131_D138_N3.2821.00
354_S357_R3.0941.00
376_R403_E2.7451.00
258_S263_N2.7151.00
41_A100_L2.7091.00
257_L267_Y2.6761.00
36_L57_V2.5751.00
167_L173_V2.5741.00
420_Y439_A2.4421.00
131_D137_L2.4081.00
170_G173_V2.3991.00
460_Y465_M2.3871.00
127_V130_T2.3371.00
257_L263_N2.3201.00
437_Y456_L2.2771.00
33_L71_S2.2291.00
43_H46_E2.2231.00
453_Y472_A2.2181.00
359_S363_G2.1731.00
167_L170_G2.1721.00
437_Y463_K2.1561.00
380_A404_I2.1421.00
30_E71_S2.1391.00
257_L260_A2.1341.00
340_F343_A2.1321.00
167_L174_A2.1171.00
256_T263_N2.1101.00
260_A263_N2.1091.00
19_Q26_Q2.0681.00
198_D203_M1.9931.00
437_Y441_N1.9821.00
134_S137_L1.9631.00
134_S138_N1.9571.00
200_D203_M1.9401.00
231_L236_T1.9301.00
263_N268_R1.9101.00
71_S74_E1.9091.00
43_H52_E1.9001.00
401_N427_A1.8991.00
130_T137_L1.8611.00
358_A362_L1.8591.00
262_V267_Y1.8121.00
33_L74_E1.7921.00
275_S279_V1.7790.99
210_S213_S1.7750.99
130_T138_N1.7710.99
343_A362_L1.7590.99
44_S48_L1.7420.99
53_L68_V1.7380.99
359_S379_K1.7130.99
70_Q74_E1.7030.99
167_L172_C1.6900.99
67_V70_Q1.6780.99
174_A204_V1.6760.99
67_V71_S1.6620.99
261_F265_R1.6400.99
256_T267_Y1.6210.99
216_Q219_Y1.6210.99
272_C275_S1.6210.99
32_R57_V1.6180.99
169_L174_A1.6180.99
460_Y472_A1.6120.99
39_F57_V1.6050.99
437_Y459_V1.6050.99
199_I203_M1.6010.99
263_N266_Q1.5970.99
401_N405_D1.5910.99
189_K200_D1.5870.99
66_H69_T1.5800.99
421_Q455_L1.5780.99
170_G174_A1.5760.99
39_F43_H1.5700.99
34_I63_V1.5610.99
417_S443_G1.5580.99
248_D251_S1.5350.98
50_R65_N1.5350.98
108_S112_G1.5310.98
199_I202_N1.5220.98
132_S135_H1.5190.98
255_K263_N1.5150.98
196_P203_M1.5080.98
30_E33_L1.5040.98
257_L261_F1.4840.98
260_A267_Y1.4830.98
362_L378_E1.4810.98
373_T411_P1.4730.98
30_E70_Q1.4710.98
114_E118_S1.4630.98
288_L292_Y1.4590.98
427_A435_E1.4560.98
262_V266_Q1.4530.98
29_L78_S1.4450.98
165_F172_C1.4300.98
460_Y468_E1.4300.98
199_I204_V1.4230.97
424_A456_L1.3990.97
69_T72_I1.3980.97
161_V164_F1.3970.97
245_Y248_D1.3960.97
263_N267_Y1.3840.97
47_V92_T1.3790.97
369_S372_F1.3760.97
66_H70_Q1.3620.97
259_I265_R1.3610.97
127_V131_D1.3560.97
131_D134_S1.3470.96
43_H100_L1.3380.96
189_K192_I1.3290.96
404_I422_I1.3260.96
47_V96_R1.3180.96
189_K193_L1.3160.96
456_L460_Y1.3110.96
55_D60_R1.3100.96
203_M206_K1.3070.96
239_V243_I1.3020.96
262_V265_R1.3010.96
427_A432_K1.3000.96
453_Y475_T1.2980.96
459_V463_K1.2920.95
34_I38_V1.2860.95
440_I456_L1.2820.95
300_L303_Q1.2800.95
435_E438_Q1.2750.95
67_V74_E1.2720.95
196_P204_V1.2670.95
338_T341_Y1.2600.95
91_A101_M1.2570.95
216_Q220_A1.2470.94
330_L334_G1.2450.94
256_T261_F1.2440.94
254_G257_L1.2410.94
286_T289_D1.2360.94
405_D423_K1.2360.94
169_L173_V1.2350.94
280_D283_D1.2350.94
80_K83_D1.2320.94
42_Q56_N1.2250.94
379_K403_E1.2200.94
173_V176_V1.2200.94
198_D202_N1.2120.94
404_I424_A1.2060.93
295_T307_L1.2050.93
247_I250_P1.2050.93
440_I455_L1.2010.93
337_L340_F1.1970.93
338_T346_Y1.1920.93
170_G181_L1.1870.93
255_K262_V1.1830.93
93_V99_K1.1830.93
248_D252_S1.1810.93
290_K294_I1.1790.93
30_E74_E1.1760.93
199_I206_K1.1760.93
254_G263_N1.1680.92
343_A452_N1.1600.92
76_R98_Y1.1530.92
441_N445_D1.1520.92
231_L234_F1.1480.92
358_A368_S1.1480.92
189_K203_M1.1440.91
196_P202_N1.1370.91
178_F182_D1.1250.91
276_I285_S1.1200.91
164_F169_L1.1190.91
173_V181_L1.1180.90
354_S358_A1.1170.90
190_S199_I1.1160.90
216_Q231_L1.1160.90
169_L172_C1.1090.90
206_K210_S1.1040.90
198_D204_V1.1020.90
160_W164_F1.0990.90
277_K281_N1.0980.90
91_A99_K1.0890.89
73_S77_K1.0860.89
363_G399_A1.0850.89
383_D399_A1.0850.89
172_C176_V1.0820.89
276_I283_D1.0770.89
220_A234_F1.0750.89
175_L179_S1.0720.89
257_L262_V1.0690.88
160_W163_F1.0660.88
276_I279_V1.0640.88
337_L341_Y1.0610.88
32_R67_V1.0480.87
34_I57_V1.0480.87
119_S123_I1.0470.87
401_N430_K1.0460.87
296_N307_L1.0450.87
343_A347_L1.0440.87
331_P336_L1.0370.87
188_S191_R1.0340.87
193_L198_D1.0300.86
283_D286_T1.0280.86
295_T314_L1.0230.86
471_D475_T1.0220.86
281_N285_S1.0190.86
259_I266_Q1.0190.86
54_I62_I1.0160.86
47_V97_G1.0110.85
420_Y446_L1.0110.85
165_F170_G1.0090.85
442_T445_D1.0080.85
343_A361_L1.0020.85
75_L90_I1.0010.85
190_S203_M1.0010.85
359_S382_V0.9990.85
238_M243_I0.9950.85
450_W480_R0.9940.84
314_L317_P0.9910.84
119_S124_P0.9860.84
41_A44_S0.9860.84
165_F173_V0.9840.84
230_S233_T0.9790.84
33_L36_L0.9750.83
200_D204_V0.9720.83
359_S386_R0.9690.83
220_A232_N0.9670.83
257_L265_R0.9660.83
376_R406_N0.9660.83
427_A439_A0.9640.83
363_G379_K0.9640.83
437_Y460_Y0.9620.82
49_S52_E0.9600.82
383_D403_E0.9590.82
461_E473_Y0.9520.82
308_E312_K0.9510.82
401_N432_K0.9500.82
236_T243_I0.9490.82
278_L282_A0.9490.82
364_E367_Q0.9460.81
59_K67_V0.9450.81
118_S121_P0.9410.81
189_K199_I0.9410.81
282_A286_T0.9390.81
94_P97_G0.9350.81
249_E252_S0.9340.81
261_F266_Q0.9330.80
109_E113_E0.9320.80
401_N426_S0.9310.80
257_L268_R0.9290.80
81_D88_V0.9280.80
340_F372_F0.9270.80
454_V473_Y0.9270.80
441_N456_L0.9260.80
343_A346_Y0.9250.80
258_S266_Q0.9240.80
401_N423_K0.9230.80
338_T342_Q0.9220.80
172_C181_L0.9210.80
440_I459_V0.9200.80
279_V284_G0.9190.79
231_L239_V0.9170.79
311_S314_L0.9090.79
234_F239_V0.9080.79
174_A181_L0.9060.79
170_G179_S0.9010.78
162_W180_S0.9010.78
450_W476_A0.9010.78
289_D303_Q0.8950.78
287_M307_L0.8950.78
285_S288_L0.8910.77
170_G177_A0.8890.77
226_L231_L0.8810.77
116_M119_S0.8800.76
260_A265_R0.8790.76
382_V386_R0.8770.76
362_L375_A0.8770.76
276_I281_N0.8760.76
32_R70_Q0.8760.76
460_Y463_K0.8720.76
319_P326_L0.8680.75
254_G258_S0.8680.75
358_A375_A0.8630.75
94_P98_Y0.8620.75
324_E328_K0.8610.75
307_L314_L0.8600.75
186_P189_K0.8590.75
426_S430_K0.8530.74
276_I280_D0.8500.74
36_L48_L0.8480.74
199_I205_N0.8470.74
423_K427_A0.8450.73
226_L229_T0.8450.73
208_C216_Q0.8450.73
43_H73_S0.8430.73
132_S138_N0.8430.73
167_L177_A0.8420.73
401_N408_V0.8390.73
322_M325_T0.8380.73
468_E471_D0.8340.73
170_G175_L0.8340.73
165_F177_A0.8330.72
406_N409_T0.8320.72
256_T265_R0.8320.72
288_L291_R0.8310.72
331_P338_T0.8300.72
335_A344_H0.8300.72
185_L189_K0.8300.72
72_I98_Y0.8260.72
172_C175_L0.8230.72
433_T459_V0.8200.71
335_A347_L0.8150.71
258_S265_R0.8150.71
366_V376_R0.8140.71
424_A455_L0.8120.70
249_E253_S0.8110.70
59_K63_V0.8090.70
163_F174_A0.8090.70
40_F48_L0.8040.70
43_H56_N0.8020.70
307_L311_S0.7990.69
257_L266_Q0.7980.69
270_Q273_F0.7970.69
236_T239_V0.7960.69
335_A339_N0.7940.69
295_T299_Q0.7930.69
305_D309_S0.7910.68
259_I263_N0.7900.68
89_Y102_V0.7890.68
408_V420_Y0.7880.68
133_P138_N0.7840.68
205_N216_Q0.7770.67
380_A426_S0.7770.67
358_A361_L0.7770.67
126_A131_D0.7750.67
228_A233_T0.7740.67
213_S216_Q0.7740.67
196_P201_I0.7720.67
336_L343_A0.7710.66
242_K245_Y0.7670.66
50_R54_I0.7670.66
127_V134_S0.7660.66
365_I375_A0.7630.66
260_A264_Q0.7630.66
133_P137_L0.7590.65
473_Y477_F0.7580.65
471_D474_L0.7560.65
364_E368_S0.7560.65
213_S228_A0.7550.65
398_A402_T0.7530.65
83_D89_Y0.7520.65
254_G268_R0.7510.64
308_E311_S0.7500.64
458_K462_M0.7480.64
365_I368_S0.7470.64
361_L364_E0.7450.64
31_P67_V0.7440.64
339_N345_D0.7440.64
233_T239_V0.7430.64
174_A178_F0.7410.63
175_L180_S0.7410.63
281_N284_G0.7370.63
296_N308_E0.7360.63
310_L314_L0.7350.63
65_N96_R0.7350.63
276_I288_L0.7350.63
309_S314_L0.7330.63
282_A285_S0.7310.62
75_L97_G0.7300.62
292_Y307_L0.7280.62
339_N361_L0.7260.62
127_V137_L0.7260.62
64_T69_T0.7240.62
250_P253_S0.7240.62
279_V286_T0.7240.62
22_R25_R0.7230.61
20_I30_E0.7210.61
201_I204_V0.7200.61
260_A266_Q0.7190.61
383_D388_S0.7180.61
405_D445_D0.7170.61
21_S26_Q0.7170.61
19_Q22_R0.7150.61
126_A135_H0.7130.60
27_L55_D0.7120.60
258_S264_Q0.7110.60
323_Q326_L0.7110.60
123_I138_N0.7110.60
222_G228_A0.7100.60
303_Q307_L0.7100.60
33_L67_V0.7090.60
455_L460_Y0.7090.60
31_P45_G0.7080.60
271_Q282_A0.7040.59
428_L433_T0.7030.59
219_Y232_N0.7010.59
335_A368_S0.7010.59
64_T67_V0.7010.59
78_S137_L0.7000.59
255_K267_Y0.7000.59
426_S458_K0.6980.59
172_C177_A0.6980.59
443_G452_N0.6970.59
170_G176_V0.6960.59
111_E115_I0.6960.59
333_R336_L0.6960.59
186_P190_S0.6950.58
230_S239_V0.6930.58
259_I267_Y0.6910.58
32_R35_D0.6910.58
221_I232_N0.6910.58
21_S75_L0.6900.58
474_L478_N0.6900.58
216_Q230_S0.6890.58
119_S125_E0.6860.57
34_I65_N0.6850.57
194_L203_M0.6850.57
342_Q347_L0.6840.57
443_G448_M0.6840.57
57_V69_T0.6840.57
330_L338_T0.6830.57
258_S267_Y0.6820.57
76_R97_G0.6820.57
35_D70_Q0.6810.57
244_N250_P0.6800.57
269_A277_K0.6760.56
331_P347_L0.6760.56
165_F169_L0.6750.56
322_M326_L0.6750.56
408_V419_I0.6690.56
244_N249_E0.6690.56
63_V96_R0.6690.56
30_E35_D0.6690.56
280_D284_G0.6690.56
256_T264_Q0.6690.56
289_D292_Y0.6680.55
343_A358_A0.6680.55
127_V138_N0.6660.55
70_Q99_K0.6650.55
189_K206_K0.6630.55
216_Q233_T0.6610.55
189_K204_V0.6600.55
232_N236_T0.6540.54
406_N410_L0.6530.54
130_T133_P0.6500.53
50_R92_T0.6490.53
33_L41_A0.6490.53
308_E315_N0.6480.53
216_Q224_G0.6460.53
331_P337_L0.6450.53
66_H71_S0.6430.53
200_D205_N0.6430.53
105_I115_I0.6430.53
52_E56_N0.6420.53
218_S229_T0.6420.53
103_P106_W0.6390.52
292_Y295_T0.6390.52
409_T470_A0.6380.52
423_K439_A0.6370.52
130_T134_S0.6370.52
198_D206_K0.6360.52
72_I97_G0.6330.52
168_S173_V0.6330.52
163_F169_L0.6320.51
441_N468_E0.6320.51
420_Y442_T0.6310.51
261_F267_Y0.6290.51
376_R410_L0.6280.51
213_S285_S0.6270.51
269_A275_S0.6270.51
311_S315_N0.6250.51
216_Q236_T0.6250.51
265_R268_R0.6240.51
69_T92_T0.6230.50
81_D90_I0.6230.50
30_E57_V0.6220.50
50_R63_V0.6200.50
173_V179_S0.6200.50
196_P199_I0.6200.50
167_L171_I0.6190.50
296_N299_Q0.6180.50
461_E466_N0.6170.50
458_K473_Y0.6170.50
79_L159_F0.6160.50
288_L303_Q0.6160.50
234_F238_M0.6160.50
271_Q274_M0.6150.50
258_S268_R0.6150.50
229_T232_N0.6150.50
34_I64_T0.6140.49
295_T311_S0.6130.49
404_I426_S0.6130.49
255_K258_S0.6130.49
20_I34_I0.6120.49
271_Q276_I0.6120.49
283_D288_L0.6120.49
169_L181_L0.6110.49
331_P334_G0.6100.49
325_T328_K0.6090.49
404_I440_I0.6090.49
457_G476_A0.6060.48
428_L452_N0.6050.48
238_M242_K0.6050.48
52_E104_V0.6040.48
197_R202_N0.6040.48
284_G306_L0.6040.48
274_M288_L0.6030.48
216_Q229_T0.6030.48
450_W479_L0.6030.48
93_V96_R0.6020.48
427_A430_K0.6020.48
236_T241_D0.6020.48
39_F56_N0.6020.48
238_M241_D0.6020.48
245_Y252_S0.6010.48
34_I95_K0.6010.48
201_I205_N0.6010.48
64_T71_S0.6000.48
54_I59_K0.6000.48
304_N307_L0.5970.47
237_F241_D0.5960.47
202_N205_N0.5940.47
48_L99_K0.5930.47
31_P43_H0.5930.47
57_V67_V0.5920.47
275_S304_N0.5910.47
337_L343_A0.5880.46
239_V242_K0.5880.46
69_T94_P0.5880.46
125_E405_D0.5870.46
340_F346_Y0.5860.46
163_F166_L0.5810.46
310_L328_K0.5790.45
30_E95_K0.5780.45
123_I434_D0.5780.45
61_S67_V0.5770.45
54_I65_N0.5740.45
244_N248_D0.5740.45
366_V375_A0.5730.45
92_T97_G0.5720.45
380_A428_L0.5720.45
283_D289_D0.5700.44
179_S183_T0.5700.44
115_I137_L0.5700.44
261_F268_R0.5700.44
255_K266_Q0.5700.44
437_Y440_I0.5690.44
167_L181_L0.5670.44
275_S280_D0.5650.44
190_S198_D0.5640.44
216_Q234_F0.5610.43
164_F181_L0.5600.43
276_I284_G0.5580.43
216_Q232_N0.5580.43
358_A382_V0.5570.43
241_D245_Y0.5560.43
269_A272_C0.5550.43
274_M286_T0.5550.43
82_N101_M0.5540.43
221_I231_L0.5540.43
256_T268_R0.5530.43
379_K383_D0.5520.42
135_H138_N0.5520.42
212_S216_Q0.5520.42
90_I100_L0.5510.42
309_S315_N0.5510.42
331_P345_D0.5500.42
377_A422_I0.5490.42
342_Q346_Y0.5490.42
44_S119_S0.5470.42
262_V276_I0.5470.42
374_Y378_E0.5470.42
475_T479_L0.5460.42
428_L462_M0.5450.42
167_L175_L0.5450.42
382_V427_A0.5450.42
411_P415_N0.5440.42
288_L294_I0.5430.41
285_S295_T0.5430.41
130_T135_H0.5420.41
226_L230_S0.5390.41
32_R94_P0.5360.41
283_D290_K0.5360.41
37_L75_L0.5360.41
237_F242_K0.5360.41
271_Q280_D0.5360.41
276_I282_A0.5350.41
404_I419_I0.5350.41
456_L472_A0.5340.40
264_Q267_Y0.5340.40
283_D293_V0.5330.40
331_P340_F0.5320.40
303_Q306_L0.5310.40
126_A138_N0.5300.40
211_W217_L0.5300.40
337_L347_L0.5300.40
314_L318_W0.5300.40
274_M279_V0.5290.40
404_I411_P0.5290.40
320_Q323_Q0.5270.40
47_V101_M0.5240.39
168_S172_C0.5240.39
301_A305_D0.5230.39
229_T234_F0.5230.39
159_F442_T0.5220.39
194_L199_I0.5220.39
284_G299_Q0.5210.39
193_L202_N0.5210.39
275_S285_S0.5210.39
383_D386_R0.5200.39
226_L232_N0.5190.39
421_Q470_A0.5180.39
169_L175_L0.5180.39
52_E63_V0.5170.39
434_D439_A0.5170.39
257_L264_Q0.5170.39
83_D88_V0.5160.39
256_T260_A0.5160.39
220_A226_L0.5150.38
282_A289_D0.5140.38
228_A239_V0.5130.38
233_T236_T0.5130.38
299_Q315_N0.5130.38
30_E69_T0.5110.38
107_Y111_E0.5110.38
166_L173_V0.5090.38
36_L72_I0.5090.38
168_S171_I0.5080.38
176_V180_S0.5060.37
454_V458_K0.5060.37
107_Y110_E0.5050.37
277_K280_D0.5040.37
296_N305_D0.5030.37
344_H347_L0.5020.37
213_S218_S0.5010.37
176_V179_S0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ly7A 2 0.6152 100 0.591 Contact Map
4ixaA 1 0.1973 99.9 0.75 Contact Map
2jzyA 1 0.2012 99.9 0.752 Contact Map
4nhjA 2 0.1973 99.9 0.753 Contact Map
2hwvA 1 0.1953 99.9 0.754 Contact Map
1opcA 1 0.1914 99.9 0.756 Contact Map
2zxjA 1 0.1934 99.9 0.757 Contact Map
2hqnA 1 0.209 99.9 0.758 Contact Map
2k4jA 1 0.1973 99.9 0.759 Contact Map
3q9vA 1 0.1914 99.9 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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