GREMLIN Database
PUUC - Aldehyde dehydrogenase PuuC
UniProt: P23883 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10036
Length: 495 (454)
Sequences: 36383 (21826)
Seq/√Len: 1024.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_E409_T5.2071.00
254_K259_S3.5641.00
312_E407_R3.2431.00
284_Q321_L3.1801.00
315_A407_R2.9781.00
388_D391_A2.8031.00
278_A311_E2.7961.00
67_R236_D2.7811.00
38_E50_K2.7541.00
372_N380_G2.6681.00
347_C351_D2.6561.00
288_S325_Q2.5771.00
319_L405_V2.5771.00
359_E392_S2.5731.00
202_R205_G2.5331.00
95_E129_R2.5051.00
358_R362_S2.4591.00
278_A313_S2.4461.00
97_H100_E2.4151.00
357_I379_I2.3761.00
431_T437_A2.3151.00
67_R238_D2.2981.00
38_E47_P2.2471.00
55_K58_D2.2171.00
208_K214_D2.1881.00
98_A122_P2.1561.00
90_L207_A2.1191.00
354_H358_R2.0981.00
359_E363_K2.0691.00
344_L353_V2.0641.00
93_L209_E2.0531.00
156_E487_K2.0421.00
366_L386_D2.0341.00
411_E436_R2.0041.00
354_H373_A1.9951.00
195_K346_D1.9871.00
422_Q468_Q1.9721.00
323_K327_Q1.9501.00
274_N290_T1.9351.00
439_R443_R1.9281.00
86_V212_L1.9141.00
229_Q233_R1.8941.00
354_H379_I1.8931.00
100_E202_R1.8871.00
155_R481_E1.8851.00
317_E321_L1.8821.00
279_D436_R1.8551.00
99_E118_R1.7951.00
64_S236_D1.7911.00
155_R484_T1.7871.00
93_L210_A1.7851.00
309_L417_L1.7811.00
368_L385_V1.7791.00
445_K467_K1.7771.00
309_L414_A1.7681.00
361_E367_L1.7631.00
251_Q254_K1.7551.00
384_F393_L1.7461.00
311_E408_F1.7451.00
250_K468_Q1.7441.00
71_E74_D1.7391.00
93_L96_A1.7351.00
411_E439_R1.7251.00
60_D230_A1.6951.00
394_S406_T1.6921.00
93_L206_L1.6861.00
389_P417_L1.6851.00
97_H209_E1.6841.00
233_R255_D1.6821.00
326_A383_I1.6781.00
60_D64_S1.6711.00
204_A219_V1.6381.00
70_F76_S1.6271.00
290_T318_F1.6221.00
104_L202_R1.6191.00
88_N129_R1.6161.00
413_Q416_Q1.6091.00
392_S396_E1.6011.00
323_K368_L1.5931.00
315_A319_L1.5881.00
295_F326_A1.5821.00
128_I179_G1.5751.00
187_S216_V1.5741.00
47_P50_K1.5621.00
308_L403_L1.5601.00
409_T413_Q1.5591.00
283_L321_L1.5571.00
320_A324_Q1.5551.00
316_D407_R1.5501.00
79_S82_K1.5321.00
95_E125_A1.5291.00
92_D96_A1.5271.00
60_D234_H1.5251.00
355_S392_S1.5151.00
223_F226_E1.4791.00
321_L324_Q1.4761.00
412_E443_R1.4721.00
347_C377_A1.4681.00
278_A436_R1.4591.00
45_Q375_L1.4571.00
88_N136_D1.4561.00
92_D129_R1.4471.00
358_R361_E1.4421.00
82_K85_A1.4401.00
89_K92_D1.4391.00
309_L408_F1.4381.00
289_A430_W1.4361.00
287_A321_L1.4351.00
427_A446_A1.4291.00
205_G209_E1.4191.00
277_F436_R1.4171.00
366_L385_V1.4151.00
134_A137_K1.4081.00
99_E103_L1.4041.00
290_T308_L1.3981.00
310_L318_F1.3941.00
36_T50_K1.3901.00
317_E320_A1.3891.00
91_A129_R1.3881.00
103_L107_L1.3851.00
77_L443_R1.3831.00
325_Q328_N1.3811.00
128_I175_C1.3791.00
163_A188_V1.3671.00
356_F398_I1.3561.00
58_D61_R1.3531.00
106_T116_S1.3521.00
367_L384_F1.3491.00
315_A385_V1.3481.00
154_V442_R1.3471.00
277_F408_F1.3411.00
413_Q417_L1.3401.00
253_L471_N1.3331.00
78_S82_K1.3301.00
46_A375_L1.3241.00
353_V400_G1.3201.00
103_L335_L1.3161.00
40_V47_P1.3131.00
97_H202_R1.3111.00
70_F187_S1.3111.00
330_Q338_A1.3051.00
363_K392_S1.2981.00
239_A265_W1.2971.00
204_A217_L1.2911.00
350_A379_I1.2871.00
41_D44_T1.2871.00
408_F417_L1.2831.00
351_D355_S1.2781.00
35_E53_R1.2701.00
324_Q327_Q1.2681.00
410_S413_Q1.2641.00
350_A354_H1.2611.00
415_L440_M1.2601.00
63_M234_H1.2541.00
174_T190_L1.2511.00
316_D320_A1.2391.00
277_F440_M1.2371.00
319_L323_K1.2291.00
207_A217_L1.2281.00
113_I118_R1.2171.00
91_A95_E1.2161.00
101_L202_R1.2131.00
350_A373_A1.2111.00
327_Q369_D1.2071.00
311_E410_S1.2031.00
347_C350_A1.1931.00
311_E314_I1.1891.00
333_H336_D1.1881.00
360_G384_F1.1851.00
63_M236_D1.1801.00
275_I414_A1.1751.00
152_M438_H1.1741.00
314_I317_E1.1701.00
106_T334_P1.1671.00
390_N395_R1.1661.00
64_S68_G1.1611.00
478_H481_E1.1561.00
322_L403_L1.1551.00
155_R486_L1.1541.00
324_Q328_N1.1541.00
330_Q340_T1.1521.00
389_P420_D1.1481.00
103_L113_I1.1461.00
53_R223_F1.1431.00
90_L206_L1.1431.00
427_A449_V1.1391.00
332_G339_T1.1351.00
318_F322_L1.1311.00
90_L212_L1.1271.00
78_S86_V1.1251.00
395_R420_D1.1241.00
215_G218_N1.1241.00
59_I227_A1.1221.00
441_S489_I1.1211.00
89_K93_L1.1191.00
194_E223_F1.1181.00
477_L481_E1.1181.00
63_M237_I1.1111.00
229_Q255_D1.1101.00
329_W341_M1.1091.00
248_T251_Q1.1091.00
178_L217_L1.1081.00
412_E439_R1.1041.00
321_L325_Q1.1031.00
41_D333_H1.1031.00
395_R422_Q1.1021.00
464_G473_R1.1011.00
229_Q251_Q1.0991.00
365_Q384_F1.0981.00
90_L128_I1.0931.00
355_S359_E1.0921.00
437_A451_V1.0901.00
163_A241_A1.0891.00
251_Q255_D1.0871.00
230_A234_H1.0841.00
43_V334_P1.0761.00
141_E478_H1.0751.00
473_R485_E1.0751.00
275_I440_M1.0721.00
363_K391_A1.0711.00
253_L264_V1.0711.00
194_E225_H1.0701.00
65_A218_N1.0681.00
141_E477_L1.0651.00
88_N133_E1.0621.00
274_N305_G1.0621.00
49_A198_L1.0611.00
319_L385_V1.0601.00
247_R251_Q1.0591.00
271_K306_T1.0511.00
158_V239_A1.0511.00
98_A118_R1.0511.00
201_I221_T1.0471.00
37_F53_R1.0441.00
478_H486_L1.0441.00
101_L206_L1.0431.00
319_L368_L1.0361.00
327_Q380_G1.0361.00
415_L443_R1.0361.00
169_F301_V1.0361.00
178_L188_V1.0331.00
97_H206_L1.0301.00
350_A377_A1.0271.00
56_S230_A1.0261.00
433_D436_R1.0241.00
412_E416_Q1.0231.00
250_K261_M1.0221.00
275_I418_A1.0221.00
370_G382_T1.0151.00
53_R226_E1.0141.00
282_D432_R1.0131.00
353_V402_V1.0121.00
96_A209_E1.0111.00
74_D78_S1.0091.00
162_A237_I1.0051.00
370_G380_G1.0001.00
194_E224_G0.9971.00
69_V187_S0.9931.00
201_I219_V0.9921.00
45_Q377_A0.9881.00
408_F414_A0.9871.00
154_V489_I0.9831.00
71_E416_Q0.9811.00
124_A175_C0.9781.00
273_A427_A0.9741.00
365_Q391_A0.9731.00
323_K369_D0.9711.00
411_E440_M0.9661.00
84_K136_D0.9601.00
71_E445_K0.9561.00
162_A231_L0.9441.00
97_H205_G0.9421.00
282_D285_Q0.9401.00
238_D445_K0.9381.00
428_A454_Y0.9371.00
253_L257_G0.9361.00
466_Y485_E0.9351.00
160_V237_I0.9341.00
160_V187_S0.9321.00
71_E77_L0.9321.00
111_K120_D0.9311.00
135_I183_A0.9311.00
359_E362_S0.9301.00
158_V263_R0.9251.00
41_D107_L0.9241.00
316_D319_L0.9231.00
100_E103_L0.9221.00
293_G305_G0.9221.00
356_F359_E0.9201.00
284_Q317_E0.9201.00
67_R71_E0.9181.00
205_G208_K0.9171.00
56_S226_E0.9141.00
107_L335_L0.9141.00
277_F411_E0.9131.00
156_E442_R0.9121.00
387_V391_A0.9121.00
294_I306_T0.9101.00
245_S248_T0.9081.00
416_Q420_D0.9071.00
287_A322_L0.9061.00
76_S445_K0.9011.00
285_Q289_A0.8961.00
315_A405_V0.8951.00
361_E384_F0.8941.00
88_N132_A0.8891.00
41_D46_A0.8881.00
291_A325_Q0.8851.00
151_A461_V0.8841.00
356_F392_S0.8821.00
389_P406_T0.8811.00
91_A132_A0.8801.00
228_G232_S0.8791.00
59_I162_A0.8771.00
161_I239_A0.8761.00
263_R485_E0.8751.00
56_S60_D0.8731.00
109_T196_S0.8721.00
355_S358_R0.8721.00
274_N430_W0.8691.00
414_A417_L0.8681.00
406_T417_L0.8671.00
94_M124_A0.8661.00
85_A89_K0.8661.00
287_A325_Q0.8651.00
156_E466_Y0.8641.00
353_V398_I0.8631.00
283_L287_A0.8601.00
240_I256_A0.8581.00
80_P84_K0.8581.00
277_F431_T0.8561.00
93_L97_H0.8541.00
427_A444_L0.8521.00
177_K474_D0.8511.00
158_V186_N0.8501.00
351_D354_H0.8501.00
240_I252_L0.8491.00
124_A171_L0.8471.00
408_F413_Q0.8461.00
84_K88_N0.8461.00
276_V318_F0.8461.00
429_V440_M0.8451.00
84_K132_A0.8431.00
31_A58_D0.8411.00
69_V216_V0.8401.00
461_V488_T0.8401.00
195_K348_A0.8361.00
286_A290_T0.8341.00
360_G398_I0.8331.00
158_V485_E0.8321.00
77_L442_R0.8311.00
253_L261_M0.8281.00
40_V377_A0.8241.00
287_A318_F0.8241.00
253_L256_A0.8241.00
43_V378_A0.8231.00
438_H442_R0.8221.00
61_R65_A0.8211.00
250_K254_K0.8171.00
371_R382_T0.8101.00
415_L419_N0.8051.00
74_D77_L0.8051.00
75_W216_V0.8031.00
190_L200_A0.8021.00
366_L369_D0.8011.00
180_P479_A0.8001.00
287_A291_A0.8001.00
37_F223_F0.7961.00
212_L217_L0.7961.00
249_G268_A0.7951.00
94_M125_A0.7941.00
174_T178_L0.7941.00
357_I402_V0.7931.00
272_S306_T0.7921.00
57_V60_D0.7921.00
315_A386_D0.7911.00
65_A215_G0.7901.00
57_V61_R0.7891.00
68_G71_E0.7861.00
204_A208_K0.7831.00
353_V379_I0.7831.00
66_A218_N0.7801.00
434_L437_A0.7781.00
87_L183_A0.7771.00
184_A484_T0.7741.00
162_A240_I0.7731.00
31_A36_T0.7721.00
109_T345_I0.7721.00
286_A318_F0.7701.00
201_I205_G0.7691.00
89_K210_A0.7661.00
320_A323_K0.7661.00
61_R64_S0.7661.00
114_R340_T0.7631.00
31_A52_A0.7601.00
181_A188_V0.7591.00
446_A449_V0.7581.00
106_T113_I0.7571.00
88_N92_D0.7551.00
175_C203_L0.7511.00
242_F248_T0.7511.00
81_A136_D0.7501.00
232_S255_D0.7491.00
48_L107_L0.7491.00
192_P221_T0.7471.00
249_G266_L0.7471.00
233_R259_S0.7471.00
102_A106_T0.7451.00
273_A418_A0.7451.00
291_A322_L0.7421.00
113_I335_L0.7411.00
54_G58_D0.7381.00
86_V210_A0.7371.00
102_A113_I0.7351.00
329_W340_T0.7341.00
163_A177_K0.7321.00
322_L383_I0.7311.00
311_E411_E0.7311.00
54_G62_A0.7281.00
364_G391_A0.7261.00
277_F311_E0.7251.00
186_N484_T0.7251.00
326_A369_D0.7251.00
212_L216_V0.7231.00
41_D335_L0.7221.00
225_H229_Q0.7191.00
386_D407_R0.7161.00
171_L199_S0.7161.00
246_T468_Q0.7161.00
283_L314_I0.7151.00
95_E122_P0.7151.00
71_E76_S0.7121.00
410_S416_Q0.7111.00
348_A351_D0.7101.00
356_F396_E0.7091.00
284_Q325_Q0.7081.00
232_S252_L0.7081.00
102_A118_R0.7051.00
256_A264_V0.7031.00
222_G227_A0.7021.00
279_D431_T0.7021.00
105_E108_D0.7011.00
310_L314_I0.7001.00
107_L198_L0.6991.00
432_R435_S0.6971.00
151_A488_T0.6971.00
95_E98_A0.6951.00
323_K326_A0.6941.00
224_G228_G0.6921.00
357_I384_F0.6911.00
347_C373_A0.6891.00
59_I63_M0.6881.00
333_H339_T0.6851.00
226_E229_Q0.6841.00
174_T200_A0.6841.00
326_A329_W0.6831.00
227_A230_A0.6821.00
118_R122_P0.6811.00
190_L217_L0.6811.00
60_D236_D0.6801.00
40_V45_Q0.6791.00
349_H352_S0.6791.00
75_W86_V0.6791.00
254_K257_G0.6781.00
336_D339_T0.6781.00
331_P341_M0.6781.00
104_L198_L0.6771.00
195_K345_I0.6731.00
411_E415_L0.6721.00
101_L171_L0.6711.00
111_K115_H0.6681.00
309_L389_P0.6681.00
158_V238_D0.6671.00
162_A228_G0.6661.00
189_I218_N0.6661.00
99_E113_I0.6631.00
54_G220_V0.6621.00
389_P394_S0.6601.00
80_P135_I0.6601.00
309_L394_S0.6601.00
66_A187_S0.6601.00
59_I230_A0.6601.00
76_S156_E0.6571.00
291_A329_W0.6561.00
69_V74_D0.6541.00
346_D349_H0.6541.00
76_S443_R0.6521.00
308_L318_F0.6521.00
75_W182_L0.6521.00
371_R380_G0.6511.00
379_I382_T0.6511.00
165_V174_T0.6511.00
67_R70_F0.6501.00
263_R482_K0.6501.00
45_Q347_C0.6491.00
387_V394_S0.6491.00
298_Q341_M0.6491.00
229_Q232_S0.6491.00
363_K390_N0.6471.00
431_T436_R0.6461.00
441_S451_V0.6441.00
352_S355_S0.6431.00
92_D95_E0.6431.00
290_T322_L0.6431.00
150_L438_H0.6401.00
361_E372_N0.6381.00
194_E352_S0.6381.00
354_H357_I0.6361.00
111_K169_F0.6361.00
207_A212_L0.6351.00
417_L420_D0.6351.00
174_T203_L0.6351.00
344_L349_H0.6351.00
322_L405_V0.6341.00
71_E443_R0.6321.00
222_G228_G0.6321.00
276_V286_A0.6321.00
76_S157_P0.6311.00
35_E226_E0.6311.00
481_E484_T0.6301.00
151_A490_W0.6301.00
100_E205_G0.6301.00
152_M489_I0.6291.00
187_S218_N0.6291.00
250_K259_S0.6291.00
348_A352_S0.6261.00
434_L438_H0.6251.00
91_A125_A0.6241.00
52_A221_T0.6241.00
437_A441_S0.6231.00
265_W482_K0.6231.00
51_I197_P0.6221.00
369_D383_I0.6221.00
373_A380_G0.6211.00
154_V487_K0.6201.00
253_L266_L0.6191.00
385_V407_R0.6181.00
202_R206_L0.6181.00
177_K241_A0.6171.00
106_T335_L0.6151.00
283_L317_E0.6151.00
445_K466_Y0.6141.00
232_S240_I0.6081.00
481_E486_L0.6071.00
285_Q288_S0.6061.00
64_S67_R0.6061.00
36_T52_A0.6051.00
369_D372_N0.6041.00
323_K383_I0.6021.00
178_L190_L0.6021.00
105_E116_S0.6011.00
285_Q432_R0.6001.00
138_V484_T0.6001.00
255_D259_S0.6001.00
94_M203_L0.5981.00
121_I125_A0.5981.00
398_I402_V0.5961.00
105_E199_S0.5951.00
171_L203_L0.5951.00
194_E251_Q0.5941.00
274_N308_L0.5901.00
82_K86_V0.5901.00
80_P183_A0.5891.00
105_E120_D0.5891.00
39_T49_A0.5891.00
429_V437_A0.5881.00
65_A214_D0.5851.00
39_T108_D0.5831.00
239_A482_K0.5821.00
435_S438_H0.5811.00
161_I186_N0.5791.00
279_D433_D0.5791.00
118_R337_P0.5781.00
279_D432_R0.5771.00
387_V393_L0.5771.00
384_F387_V0.5771.00
98_A102_A0.5761.00
232_S260_N0.5761.00
94_M171_L0.5751.00
435_S439_R0.5751.00
103_L106_T0.5741.00
415_L439_R0.5731.00
121_I171_L0.5731.00
138_V480_L0.5721.00
310_L405_V0.5701.00
225_H251_Q0.5701.00
94_M128_I0.5701.00
415_L444_L0.5691.00
449_V487_K0.5681.00
62_A220_V0.5681.00
301_V304_A0.5681.00
56_S229_Q0.5681.00
86_V90_L0.5671.00
369_D373_A0.5661.00
278_A408_F0.5631.00
293_G454_Y0.5611.00
56_S233_R0.5601.00
310_L315_A0.5601.00
48_L198_L0.5601.00
365_Q369_D0.5551.00
91_A128_I0.5551.00
162_A189_I0.5551.00
203_L207_A0.5551.00
120_D169_F0.5551.00
280_C286_A0.5541.00
274_N428_A0.5541.00
357_I382_T0.5531.00
90_L93_L0.5521.00
354_H361_E0.5501.00
272_S426_G0.5501.00
163_A178_L0.5481.00
39_T197_P0.5481.00
101_L121_I0.5461.00
66_A189_I0.5451.00
418_A444_L0.5441.00
184_A480_L0.5431.00
172_L176_W0.5421.00
332_G336_D0.5421.00
367_L370_G0.5421.00
94_M101_L0.5411.00
294_I403_L0.5391.00
67_R160_V0.5381.00
394_S417_L0.5371.00
283_L286_A0.5371.00
331_P340_T0.5361.00
344_L379_I0.5361.00
393_L398_I0.5361.00
246_T250_K0.5351.00
312_E315_A0.5351.00
68_G74_D0.5351.00
305_G428_A0.5331.00
247_R348_A0.5331.00
31_A34_N0.5311.00
102_A121_I0.5311.00
267_E425_L0.5311.00
414_A418_A0.5301.00
429_V451_V0.5301.00
295_F329_W0.5271.00
445_K485_E0.5271.00
444_L449_V0.5271.00
130_W134_A0.5271.00
389_P416_Q0.5271.00
273_A446_A0.5261.00
131_Y180_P0.5261.00
51_I198_L0.5261.00
308_L405_V0.5261.00
74_D187_S0.5261.00
123_G172_L0.5251.00
241_A483_F0.5241.00
450_F453_N0.5241.00
133_E136_D0.5231.00
160_V238_D0.5221.00
161_I188_V0.5211.00
65_A69_V0.5211.00
66_A160_V0.5201.00
367_L382_T0.5191.00
448_S457_G0.5191.00
283_L318_F0.5181.00
98_A125_A0.5181.00
322_L326_A0.5151.00
35_E55_K0.5151.00
287_A314_I0.5151.00
176_W475_K0.5141.00
194_E247_R0.5141.00
134_A477_L0.5141.00
264_V471_N0.5121.00
320_A327_Q0.5111.00
182_L212_L0.5101.00
109_T297_N0.5091.00
122_P125_A0.5081.00
62_A189_I0.5081.00
411_E443_R0.5081.00
182_L217_L0.5081.00
426_G450_F0.5071.00
102_A116_S0.5071.00
161_I241_A0.5071.00
297_N301_V0.5041.00
284_Q324_Q0.5041.00
30_A52_A0.5021.00
314_I408_F0.5011.00
238_D260_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lihA 5 0.9838 100 0.033 Contact Map
4yweA 5 0.9475 100 0.034 Contact Map
4o5hA 4 0.9939 100 0.037 Contact Map
4qf6A 4 0.9859 100 0.04 Contact Map
2o2pA 5 0.9899 100 0.042 Contact Map
1a4sA 4 0.9879 100 0.042 Contact Map
4qtoA 4 0.9697 100 0.044 Contact Map
3ek1A 5 0.9697 100 0.044 Contact Map
1wndA 4 0.9495 100 0.044 Contact Map
4pz2A 4 0.9657 100 0.045 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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