PUUC - ECOLI - GREMLIN Contacts

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PUUC - Aldehyde dehydrogenase PuuC

UniProt:	P23883	Sequences: MNFHHLAYWQDKALSLAIENRLFINGEYTAAAENETFETVDPVTQAPLAKIARGKSVDIDRAMSAARGVFERGDWSLSSPAKRKAVLNKLADLMEAHAEELALLETLDTGKPIRHSLRDDIPGAARAIRWYAEAIDKVYGEVATTSSHELAMIVREPVGVIAAIVPWNFPLLLTCWKLGPALAAGNSVILKPSEKSPLSAIRLAGLAKEAGLPDGVLNVVTGFGHEAGQALSRHNDIDAIAFTGSTRTGKQLLKDAGDSNMKRVWLEAGGKSANIVFADCPDLQQAASATAAGIFYNQGQVCIAGTRLLLEESIADEFLALLKQQAQNWQPGHPLDPATTMGTLIDCAHADSVHSFIREGESKGQLLLDGRNAGLAAAIGPTIFVDVDPNASLSREEIFGPVLVVTRFTSEEQALQLANDSQYGLGAAVWTRDLSRAHRMSRRLKAGSVFVNNYNDGDMTVPFGGYKQSGNGRDKSLHALEKFTELKTIWISLEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10036
Length:	495 (454)
Sequences:	36383 (21826)
Seq/√Len:	1024.4

ECOLI - PUUC GABD FEAB ALDB BETB ABDH ALDA ASTD EUTE SAD PUTA PAAZ PROA
BACSU - ALDH4 ROCA ROCA2 ALDH1 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
312_E	409_T	5.207	1.00
254_K	259_S	3.564	1.00
312_E	407_R	3.243	1.00
284_Q	321_L	3.180	1.00
315_A	407_R	2.978	1.00
388_D	391_A	2.803	1.00
278_A	311_E	2.796	1.00
67_R	236_D	2.781	1.00
38_E	50_K	2.754	1.00
372_N	380_G	2.668	1.00
347_C	351_D	2.656	1.00
288_S	325_Q	2.577	1.00
319_L	405_V	2.577	1.00
359_E	392_S	2.573	1.00
202_R	205_G	2.533	1.00
95_E	129_R	2.505	1.00
358_R	362_S	2.459	1.00
278_A	313_S	2.446	1.00
97_H	100_E	2.415	1.00
357_I	379_I	2.376	1.00
431_T	437_A	2.315	1.00
67_R	238_D	2.298	1.00
38_E	47_P	2.247	1.00
55_K	58_D	2.217	1.00
208_K	214_D	2.188	1.00
98_A	122_P	2.156	1.00
90_L	207_A	2.119	1.00
354_H	358_R	2.098	1.00
359_E	363_K	2.069	1.00
344_L	353_V	2.064	1.00
93_L	209_E	2.053	1.00
156_E	487_K	2.042	1.00
366_L	386_D	2.034	1.00
411_E	436_R	2.004	1.00
354_H	373_A	1.995	1.00
195_K	346_D	1.987	1.00
422_Q	468_Q	1.972	1.00
323_K	327_Q	1.950	1.00
274_N	290_T	1.935	1.00
439_R	443_R	1.928	1.00
86_V	212_L	1.914	1.00
229_Q	233_R	1.894	1.00
354_H	379_I	1.893	1.00
100_E	202_R	1.887	1.00
155_R	481_E	1.885	1.00
317_E	321_L	1.882	1.00
279_D	436_R	1.855	1.00
99_E	118_R	1.795	1.00
64_S	236_D	1.791	1.00
155_R	484_T	1.787	1.00
93_L	210_A	1.785	1.00
309_L	417_L	1.781	1.00
368_L	385_V	1.779	1.00
445_K	467_K	1.777	1.00
309_L	414_A	1.768	1.00
361_E	367_L	1.763	1.00
251_Q	254_K	1.755	1.00
384_F	393_L	1.746	1.00
311_E	408_F	1.745	1.00
250_K	468_Q	1.744	1.00
71_E	74_D	1.739	1.00
93_L	96_A	1.735	1.00
411_E	439_R	1.725	1.00
60_D	230_A	1.695	1.00
394_S	406_T	1.692	1.00
93_L	206_L	1.686	1.00
389_P	417_L	1.685	1.00
97_H	209_E	1.684	1.00
233_R	255_D	1.682	1.00
326_A	383_I	1.678	1.00
60_D	64_S	1.671	1.00
204_A	219_V	1.638	1.00
70_F	76_S	1.627	1.00
290_T	318_F	1.622	1.00
104_L	202_R	1.619	1.00
88_N	129_R	1.616	1.00
413_Q	416_Q	1.609	1.00
392_S	396_E	1.601	1.00
323_K	368_L	1.593	1.00
315_A	319_L	1.588	1.00
295_F	326_A	1.582	1.00
128_I	179_G	1.575	1.00
187_S	216_V	1.574	1.00
47_P	50_K	1.562	1.00
308_L	403_L	1.560	1.00
409_T	413_Q	1.559	1.00
283_L	321_L	1.557	1.00
320_A	324_Q	1.555	1.00
316_D	407_R	1.550	1.00
79_S	82_K	1.532	1.00
95_E	125_A	1.529	1.00
92_D	96_A	1.527	1.00
60_D	234_H	1.525	1.00
355_S	392_S	1.515	1.00
223_F	226_E	1.479	1.00
321_L	324_Q	1.476	1.00
412_E	443_R	1.472	1.00
347_C	377_A	1.468	1.00
278_A	436_R	1.459	1.00
45_Q	375_L	1.457	1.00
88_N	136_D	1.456	1.00
92_D	129_R	1.447	1.00
358_R	361_E	1.442	1.00
82_K	85_A	1.440	1.00
89_K	92_D	1.439	1.00
309_L	408_F	1.438	1.00
289_A	430_W	1.436	1.00
287_A	321_L	1.435	1.00
427_A	446_A	1.429	1.00
205_G	209_E	1.419	1.00
277_F	436_R	1.417	1.00
366_L	385_V	1.415	1.00
134_A	137_K	1.408	1.00
99_E	103_L	1.404	1.00
290_T	308_L	1.398	1.00
310_L	318_F	1.394	1.00
36_T	50_K	1.390	1.00
317_E	320_A	1.389	1.00
91_A	129_R	1.388	1.00
103_L	107_L	1.385	1.00
77_L	443_R	1.383	1.00
325_Q	328_N	1.381	1.00
128_I	175_C	1.379	1.00
163_A	188_V	1.367	1.00
356_F	398_I	1.356	1.00
58_D	61_R	1.353	1.00
106_T	116_S	1.352	1.00
367_L	384_F	1.349	1.00
315_A	385_V	1.348	1.00
154_V	442_R	1.347	1.00
277_F	408_F	1.341	1.00
413_Q	417_L	1.340	1.00
253_L	471_N	1.333	1.00
78_S	82_K	1.330	1.00
46_A	375_L	1.324	1.00
353_V	400_G	1.320	1.00
103_L	335_L	1.316	1.00
40_V	47_P	1.313	1.00
97_H	202_R	1.311	1.00
70_F	187_S	1.311	1.00
330_Q	338_A	1.305	1.00
363_K	392_S	1.298	1.00
239_A	265_W	1.297	1.00
204_A	217_L	1.291	1.00
350_A	379_I	1.287	1.00
41_D	44_T	1.287	1.00
408_F	417_L	1.283	1.00
351_D	355_S	1.278	1.00
35_E	53_R	1.270	1.00
324_Q	327_Q	1.268	1.00
410_S	413_Q	1.264	1.00
350_A	354_H	1.261	1.00
415_L	440_M	1.260	1.00
63_M	234_H	1.254	1.00
174_T	190_L	1.251	1.00
316_D	320_A	1.239	1.00
277_F	440_M	1.237	1.00
319_L	323_K	1.229	1.00
207_A	217_L	1.228	1.00
113_I	118_R	1.217	1.00
91_A	95_E	1.216	1.00
101_L	202_R	1.213	1.00
350_A	373_A	1.211	1.00
327_Q	369_D	1.207	1.00
311_E	410_S	1.203	1.00
347_C	350_A	1.193	1.00
311_E	314_I	1.189	1.00
333_H	336_D	1.188	1.00
360_G	384_F	1.185	1.00
63_M	236_D	1.180	1.00
275_I	414_A	1.175	1.00
152_M	438_H	1.174	1.00
314_I	317_E	1.170	1.00
106_T	334_P	1.167	1.00
390_N	395_R	1.166	1.00
64_S	68_G	1.161	1.00
478_H	481_E	1.156	1.00
322_L	403_L	1.155	1.00
155_R	486_L	1.154	1.00
324_Q	328_N	1.154	1.00
330_Q	340_T	1.152	1.00
389_P	420_D	1.148	1.00
103_L	113_I	1.146	1.00
53_R	223_F	1.143	1.00
90_L	206_L	1.143	1.00
427_A	449_V	1.139	1.00
332_G	339_T	1.135	1.00
318_F	322_L	1.131	1.00
90_L	212_L	1.127	1.00
78_S	86_V	1.125	1.00
395_R	420_D	1.124	1.00
215_G	218_N	1.124	1.00
59_I	227_A	1.122	1.00
441_S	489_I	1.121	1.00
89_K	93_L	1.119	1.00
194_E	223_F	1.118	1.00
477_L	481_E	1.118	1.00
63_M	237_I	1.111	1.00
229_Q	255_D	1.110	1.00
329_W	341_M	1.109	1.00
248_T	251_Q	1.109	1.00
178_L	217_L	1.108	1.00
412_E	439_R	1.104	1.00
321_L	325_Q	1.103	1.00
41_D	333_H	1.103	1.00
395_R	422_Q	1.102	1.00
464_G	473_R	1.101	1.00
229_Q	251_Q	1.099	1.00
365_Q	384_F	1.098	1.00
90_L	128_I	1.093	1.00
355_S	359_E	1.092	1.00
437_A	451_V	1.090	1.00
163_A	241_A	1.089	1.00
251_Q	255_D	1.087	1.00
230_A	234_H	1.084	1.00
43_V	334_P	1.076	1.00
141_E	478_H	1.075	1.00
473_R	485_E	1.075	1.00
275_I	440_M	1.072	1.00
363_K	391_A	1.071	1.00
253_L	264_V	1.071	1.00
194_E	225_H	1.070	1.00
65_A	218_N	1.068	1.00
141_E	477_L	1.065	1.00
88_N	133_E	1.062	1.00
274_N	305_G	1.062	1.00
49_A	198_L	1.061	1.00
319_L	385_V	1.060	1.00
247_R	251_Q	1.059	1.00
271_K	306_T	1.051	1.00
158_V	239_A	1.051	1.00
98_A	118_R	1.051	1.00
201_I	221_T	1.047	1.00
37_F	53_R	1.044	1.00
478_H	486_L	1.044	1.00
101_L	206_L	1.043	1.00
319_L	368_L	1.036	1.00
327_Q	380_G	1.036	1.00
415_L	443_R	1.036	1.00
169_F	301_V	1.036	1.00
178_L	188_V	1.033	1.00
97_H	206_L	1.030	1.00
350_A	377_A	1.027	1.00
56_S	230_A	1.026	1.00
433_D	436_R	1.024	1.00
412_E	416_Q	1.023	1.00
250_K	261_M	1.022	1.00
275_I	418_A	1.022	1.00
370_G	382_T	1.015	1.00
53_R	226_E	1.014	1.00
282_D	432_R	1.013	1.00
353_V	402_V	1.012	1.00
96_A	209_E	1.011	1.00
74_D	78_S	1.009	1.00
162_A	237_I	1.005	1.00
370_G	380_G	1.000	1.00
194_E	224_G	0.997	1.00
69_V	187_S	0.993	1.00
201_I	219_V	0.992	1.00
45_Q	377_A	0.988	1.00
408_F	414_A	0.987	1.00
154_V	489_I	0.983	1.00
71_E	416_Q	0.981	1.00
124_A	175_C	0.978	1.00
273_A	427_A	0.974	1.00
365_Q	391_A	0.973	1.00
323_K	369_D	0.971	1.00
411_E	440_M	0.966	1.00
84_K	136_D	0.960	1.00
71_E	445_K	0.956	1.00
162_A	231_L	0.944	1.00
97_H	205_G	0.942	1.00
282_D	285_Q	0.940	1.00
238_D	445_K	0.938	1.00
428_A	454_Y	0.937	1.00
253_L	257_G	0.936	1.00
466_Y	485_E	0.935	1.00
160_V	237_I	0.934	1.00
160_V	187_S	0.932	1.00
71_E	77_L	0.932	1.00
111_K	120_D	0.931	1.00
135_I	183_A	0.931	1.00
359_E	362_S	0.930	1.00
158_V	263_R	0.925	1.00
41_D	107_L	0.924	1.00
316_D	319_L	0.923	1.00
100_E	103_L	0.922	1.00
293_G	305_G	0.922	1.00
356_F	359_E	0.920	1.00
284_Q	317_E	0.920	1.00
67_R	71_E	0.918	1.00
205_G	208_K	0.917	1.00
56_S	226_E	0.914	1.00
107_L	335_L	0.914	1.00
277_F	411_E	0.913	1.00
156_E	442_R	0.912	1.00
387_V	391_A	0.912	1.00
294_I	306_T	0.910	1.00
245_S	248_T	0.908	1.00
416_Q	420_D	0.907	1.00
287_A	322_L	0.906	1.00
76_S	445_K	0.901	1.00
285_Q	289_A	0.896	1.00
315_A	405_V	0.895	1.00
361_E	384_F	0.894	1.00
88_N	132_A	0.889	1.00
41_D	46_A	0.888	1.00
291_A	325_Q	0.885	1.00
151_A	461_V	0.884	1.00
356_F	392_S	0.882	1.00
389_P	406_T	0.881	1.00
91_A	132_A	0.880	1.00
228_G	232_S	0.879	1.00
59_I	162_A	0.877	1.00
161_I	239_A	0.876	1.00
263_R	485_E	0.875	1.00
56_S	60_D	0.873	1.00
109_T	196_S	0.872	1.00
355_S	358_R	0.872	1.00
274_N	430_W	0.869	1.00
414_A	417_L	0.868	1.00
406_T	417_L	0.867	1.00
94_M	124_A	0.866	1.00
85_A	89_K	0.866	1.00
287_A	325_Q	0.865	1.00
156_E	466_Y	0.864	1.00
353_V	398_I	0.863	1.00
283_L	287_A	0.860	1.00
240_I	256_A	0.858	1.00
80_P	84_K	0.858	1.00
277_F	431_T	0.856	1.00
93_L	97_H	0.854	1.00
427_A	444_L	0.852	1.00
177_K	474_D	0.851	1.00
158_V	186_N	0.850	1.00
351_D	354_H	0.850	1.00
240_I	252_L	0.849	1.00
124_A	171_L	0.847	1.00
408_F	413_Q	0.846	1.00
84_K	88_N	0.846	1.00
276_V	318_F	0.846	1.00
429_V	440_M	0.845	1.00
84_K	132_A	0.843	1.00
31_A	58_D	0.841	1.00
69_V	216_V	0.840	1.00
461_V	488_T	0.840	1.00
195_K	348_A	0.836	1.00
286_A	290_T	0.834	1.00
360_G	398_I	0.833	1.00
158_V	485_E	0.832	1.00
77_L	442_R	0.831	1.00
253_L	261_M	0.828	1.00
40_V	377_A	0.824	1.00
287_A	318_F	0.824	1.00
253_L	256_A	0.824	1.00
43_V	378_A	0.823	1.00
438_H	442_R	0.822	1.00
61_R	65_A	0.821	1.00
250_K	254_K	0.817	1.00
371_R	382_T	0.810	1.00
415_L	419_N	0.805	1.00
74_D	77_L	0.805	1.00
75_W	216_V	0.803	1.00
190_L	200_A	0.802	1.00
366_L	369_D	0.801	1.00
180_P	479_A	0.800	1.00
287_A	291_A	0.800	1.00
37_F	223_F	0.796	1.00
212_L	217_L	0.796	1.00
249_G	268_A	0.795	1.00
94_M	125_A	0.794	1.00
174_T	178_L	0.794	1.00
357_I	402_V	0.793	1.00
272_S	306_T	0.792	1.00
57_V	60_D	0.792	1.00
315_A	386_D	0.791	1.00
65_A	215_G	0.790	1.00
57_V	61_R	0.789	1.00
68_G	71_E	0.786	1.00
204_A	208_K	0.783	1.00
353_V	379_I	0.783	1.00
66_A	218_N	0.780	1.00
434_L	437_A	0.778	1.00
87_L	183_A	0.777	1.00
184_A	484_T	0.774	1.00
162_A	240_I	0.773	1.00
31_A	36_T	0.772	1.00
109_T	345_I	0.772	1.00
286_A	318_F	0.770	1.00
201_I	205_G	0.769	1.00
89_K	210_A	0.766	1.00
320_A	323_K	0.766	1.00
61_R	64_S	0.766	1.00
114_R	340_T	0.763	1.00
31_A	52_A	0.760	1.00
181_A	188_V	0.759	1.00
446_A	449_V	0.758	1.00
106_T	113_I	0.757	1.00
88_N	92_D	0.755	1.00
175_C	203_L	0.751	1.00
242_F	248_T	0.751	1.00
81_A	136_D	0.750	1.00
232_S	255_D	0.749	1.00
48_L	107_L	0.749	1.00
192_P	221_T	0.747	1.00
249_G	266_L	0.747	1.00
233_R	259_S	0.747	1.00
102_A	106_T	0.745	1.00
273_A	418_A	0.745	1.00
291_A	322_L	0.742	1.00
113_I	335_L	0.741	1.00
54_G	58_D	0.738	1.00
86_V	210_A	0.737	1.00
102_A	113_I	0.735	1.00
329_W	340_T	0.734	1.00
163_A	177_K	0.732	1.00
322_L	383_I	0.731	1.00
311_E	411_E	0.731	1.00
54_G	62_A	0.728	1.00
364_G	391_A	0.726	1.00
277_F	311_E	0.725	1.00
186_N	484_T	0.725	1.00
326_A	369_D	0.725	1.00
212_L	216_V	0.723	1.00
41_D	335_L	0.722	1.00
225_H	229_Q	0.719	1.00
386_D	407_R	0.716	1.00
171_L	199_S	0.716	1.00
246_T	468_Q	0.716	1.00
283_L	314_I	0.715	1.00
95_E	122_P	0.715	1.00
71_E	76_S	0.712	1.00
410_S	416_Q	0.711	1.00
348_A	351_D	0.710	1.00
356_F	396_E	0.709	1.00
284_Q	325_Q	0.708	1.00
232_S	252_L	0.708	1.00
102_A	118_R	0.705	1.00
256_A	264_V	0.703	1.00
222_G	227_A	0.702	1.00
279_D	431_T	0.702	1.00
105_E	108_D	0.701	1.00
310_L	314_I	0.700	1.00
107_L	198_L	0.699	1.00
432_R	435_S	0.697	1.00
151_A	488_T	0.697	1.00
95_E	98_A	0.695	1.00
323_K	326_A	0.694	1.00
224_G	228_G	0.692	1.00
357_I	384_F	0.691	1.00
347_C	373_A	0.689	1.00
59_I	63_M	0.688	1.00
333_H	339_T	0.685	1.00
226_E	229_Q	0.684	1.00
174_T	200_A	0.684	1.00
326_A	329_W	0.683	1.00
227_A	230_A	0.682	1.00
118_R	122_P	0.681	1.00
190_L	217_L	0.681	1.00
60_D	236_D	0.680	1.00
40_V	45_Q	0.679	1.00
349_H	352_S	0.679	1.00
75_W	86_V	0.679	1.00
254_K	257_G	0.678	1.00
336_D	339_T	0.678	1.00
331_P	341_M	0.678	1.00
104_L	198_L	0.677	1.00
195_K	345_I	0.673	1.00
411_E	415_L	0.672	1.00
101_L	171_L	0.671	1.00
111_K	115_H	0.668	1.00
309_L	389_P	0.668	1.00
158_V	238_D	0.667	1.00
162_A	228_G	0.666	1.00
189_I	218_N	0.666	1.00
99_E	113_I	0.663	1.00
54_G	220_V	0.662	1.00
389_P	394_S	0.660	1.00
80_P	135_I	0.660	1.00
309_L	394_S	0.660	1.00
66_A	187_S	0.660	1.00
59_I	230_A	0.660	1.00
76_S	156_E	0.657	1.00
291_A	329_W	0.656	1.00
69_V	74_D	0.654	1.00
346_D	349_H	0.654	1.00
76_S	443_R	0.652	1.00
308_L	318_F	0.652	1.00
75_W	182_L	0.652	1.00
371_R	380_G	0.651	1.00
379_I	382_T	0.651	1.00
165_V	174_T	0.651	1.00
67_R	70_F	0.650	1.00
263_R	482_K	0.650	1.00
45_Q	347_C	0.649	1.00
387_V	394_S	0.649	1.00
298_Q	341_M	0.649	1.00
229_Q	232_S	0.649	1.00
363_K	390_N	0.647	1.00
431_T	436_R	0.646	1.00
441_S	451_V	0.644	1.00
352_S	355_S	0.643	1.00
92_D	95_E	0.643	1.00
290_T	322_L	0.643	1.00
150_L	438_H	0.640	1.00
361_E	372_N	0.638	1.00
194_E	352_S	0.638	1.00
354_H	357_I	0.636	1.00
111_K	169_F	0.636	1.00
207_A	212_L	0.635	1.00
417_L	420_D	0.635	1.00
174_T	203_L	0.635	1.00
344_L	349_H	0.635	1.00
322_L	405_V	0.634	1.00
71_E	443_R	0.632	1.00
222_G	228_G	0.632	1.00
276_V	286_A	0.632	1.00
76_S	157_P	0.631	1.00
35_E	226_E	0.631	1.00
481_E	484_T	0.630	1.00
151_A	490_W	0.630	1.00
100_E	205_G	0.630	1.00
152_M	489_I	0.629	1.00
187_S	218_N	0.629	1.00
250_K	259_S	0.629	1.00
348_A	352_S	0.626	1.00
434_L	438_H	0.625	1.00
91_A	125_A	0.624	1.00
52_A	221_T	0.624	1.00
437_A	441_S	0.623	1.00
265_W	482_K	0.623	1.00
51_I	197_P	0.622	1.00
369_D	383_I	0.622	1.00
373_A	380_G	0.621	1.00
154_V	487_K	0.620	1.00
253_L	266_L	0.619	1.00
385_V	407_R	0.618	1.00
202_R	206_L	0.618	1.00
177_K	241_A	0.617	1.00
106_T	335_L	0.615	1.00
283_L	317_E	0.615	1.00
445_K	466_Y	0.614	1.00
232_S	240_I	0.608	1.00
481_E	486_L	0.607	1.00
285_Q	288_S	0.606	1.00
64_S	67_R	0.606	1.00
36_T	52_A	0.605	1.00
369_D	372_N	0.604	1.00
323_K	383_I	0.602	1.00
178_L	190_L	0.602	1.00
105_E	116_S	0.601	1.00
285_Q	432_R	0.600	1.00
138_V	484_T	0.600	1.00
255_D	259_S	0.600	1.00
94_M	203_L	0.598	1.00
121_I	125_A	0.598	1.00
398_I	402_V	0.596	1.00
105_E	199_S	0.595	1.00
171_L	203_L	0.595	1.00
194_E	251_Q	0.594	1.00
274_N	308_L	0.590	1.00
82_K	86_V	0.590	1.00
80_P	183_A	0.589	1.00
105_E	120_D	0.589	1.00
39_T	49_A	0.589	1.00
429_V	437_A	0.588	1.00
65_A	214_D	0.585	1.00
39_T	108_D	0.583	1.00
239_A	482_K	0.582	1.00
435_S	438_H	0.581	1.00
161_I	186_N	0.579	1.00
279_D	433_D	0.579	1.00
118_R	337_P	0.578	1.00
279_D	432_R	0.577	1.00
387_V	393_L	0.577	1.00
384_F	387_V	0.577	1.00
98_A	102_A	0.576	1.00
232_S	260_N	0.576	1.00
94_M	171_L	0.575	1.00
435_S	439_R	0.575	1.00
103_L	106_T	0.574	1.00
415_L	439_R	0.573	1.00
121_I	171_L	0.573	1.00
138_V	480_L	0.572	1.00
310_L	405_V	0.570	1.00
225_H	251_Q	0.570	1.00
94_M	128_I	0.570	1.00
415_L	444_L	0.569	1.00
449_V	487_K	0.568	1.00
62_A	220_V	0.568	1.00
301_V	304_A	0.568	1.00
56_S	229_Q	0.568	1.00
86_V	90_L	0.567	1.00
369_D	373_A	0.566	1.00
278_A	408_F	0.563	1.00
293_G	454_Y	0.561	1.00
56_S	233_R	0.560	1.00
310_L	315_A	0.560	1.00
48_L	198_L	0.560	1.00
365_Q	369_D	0.555	1.00
91_A	128_I	0.555	1.00
162_A	189_I	0.555	1.00
203_L	207_A	0.555	1.00
120_D	169_F	0.555	1.00
280_C	286_A	0.554	1.00
274_N	428_A	0.554	1.00
357_I	382_T	0.553	1.00
90_L	93_L	0.552	1.00
354_H	361_E	0.550	1.00
272_S	426_G	0.550	1.00
163_A	178_L	0.548	1.00
39_T	197_P	0.548	1.00
101_L	121_I	0.546	1.00
66_A	189_I	0.545	1.00
418_A	444_L	0.544	1.00
184_A	480_L	0.543	1.00
172_L	176_W	0.542	1.00
332_G	336_D	0.542	1.00
367_L	370_G	0.542	1.00
94_M	101_L	0.541	1.00
294_I	403_L	0.539	1.00
67_R	160_V	0.538	1.00
394_S	417_L	0.537	1.00
283_L	286_A	0.537	1.00
331_P	340_T	0.536	1.00
344_L	379_I	0.536	1.00
393_L	398_I	0.536	1.00
246_T	250_K	0.535	1.00
312_E	315_A	0.535	1.00
68_G	74_D	0.535	1.00
305_G	428_A	0.533	1.00
247_R	348_A	0.533	1.00
31_A	34_N	0.531	1.00
102_A	121_I	0.531	1.00
267_E	425_L	0.531	1.00
414_A	418_A	0.530	1.00
429_V	451_V	0.530	1.00
295_F	329_W	0.527	1.00
445_K	485_E	0.527	1.00
444_L	449_V	0.527	1.00
130_W	134_A	0.527	1.00
389_P	416_Q	0.527	1.00
273_A	446_A	0.526	1.00
131_Y	180_P	0.526	1.00
51_I	198_L	0.526	1.00
308_L	405_V	0.526	1.00
74_D	187_S	0.526	1.00
123_G	172_L	0.525	1.00
241_A	483_F	0.524	1.00
450_F	453_N	0.524	1.00
133_E	136_D	0.523	1.00
160_V	238_D	0.522	1.00
161_I	188_V	0.521	1.00
65_A	69_V	0.521	1.00
66_A	160_V	0.520	1.00
367_L	382_T	0.519	1.00
448_S	457_G	0.519	1.00
283_L	318_F	0.518	1.00
98_A	125_A	0.518	1.00
322_L	326_A	0.515	1.00
35_E	55_K	0.515	1.00
287_A	314_I	0.515	1.00
176_W	475_K	0.514	1.00
194_E	247_R	0.514	1.00
134_A	477_L	0.514	1.00
264_V	471_N	0.512	1.00
320_A	327_Q	0.511	1.00
182_L	212_L	0.510	1.00
109_T	297_N	0.509	1.00
122_P	125_A	0.508	1.00
62_A	189_I	0.508	1.00
411_E	443_R	0.508	1.00
182_L	217_L	0.508	1.00
426_G	450_F	0.507	1.00
102_A	116_S	0.507	1.00
161_I	241_A	0.507	1.00
297_N	301_V	0.504	1.00
284_Q	324_Q	0.504	1.00
30_A	52_A	0.502	1.00
314_I	408_F	0.501	1.00
238_D	260_N	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lihA	5	0.9838	100	0.033	Contact Map
4yweA	5	0.9475	100	0.034	Contact Map
4o5hA	4	0.9939	100	0.037	Contact Map
4qf6A	4	0.9859	100	0.04	Contact Map
2o2pA	5	0.9899	100	0.042	Contact Map
1a4sA	4	0.9879	100	0.042	Contact Map
4qtoA	4	0.9697	100	0.044	Contact Map
3ek1A	5	0.9697	100	0.044	Contact Map
1wndA	4	0.9495	100	0.044	Contact Map
4pz2A	4	0.9657	100	0.045	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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