GREMLIN Database
FMT - Methionyl-tRNA formyltransferase
UniProt: P23882 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11268
Length: 315 (301)
Sequences: 5535 (4016)
Seq/√Len: 231.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_E156_S3.8911.00
97_K144_V3.5611.00
97_K101_E3.3921.00
198_D201_L3.2361.00
296_S299_D3.0601.00
219_L223_Q2.8941.00
155_L182_T2.6991.00
24_L59_K2.6191.00
215_I224_L2.5751.00
138_T151_M2.5561.00
163_D171_K2.5191.00
143_D148_T2.4301.00
163_D167_T2.3841.00
21_D55_L2.3211.00
6_R29_N2.2401.00
145_G148_T2.2181.00
252_S285_L2.2131.00
252_S283_N2.2021.00
225_E251_A2.1941.00
117_R132_D2.1601.00
228_I251_A2.1461.00
139_I183_T2.1421.00
186_Q191_T2.1421.00
250_K286_S2.1271.00
286_S294_A2.1061.00
219_L227_C2.0671.00
32_G81_L2.0291.00
21_D25_S2.0241.00
55_L59_K2.0211.00
250_K285_L2.0081.00
118_W130_A1.9991.00
118_W132_D1.9931.00
274_Q281_I1.9841.00
76_Q80_E1.9701.00
85_V184_L1.9331.00
220_S223_Q1.9081.00
274_Q283_N1.9081.00
125_Q165_S1.8711.00
129_W230_A1.8511.00
166_G233_P1.8461.00
284_L287_L1.8131.00
134_E158_P1.8041.00
298_Q302_N1.7881.00
261_A264_T1.7791.00
157_C175_L1.7651.00
244_Q290_A1.7571.00
62_P77_L1.7521.00
141_Q194_P1.7511.00
199_E202_V1.7511.00
150_D196_V1.7441.00
299_D302_N1.6911.00
19_H110_V1.6691.00
157_C171_K1.6561.00
249_W294_A1.6531.00
8_I83_A1.6401.00
217_W239_L1.6081.00
55_L58_E1.5901.00
160_T163_D1.5851.00
155_L178_Q1.5701.00
126_R212_E1.5541.00
272_G283_N1.5371.00
251_A282_L1.5361.00
77_L80_E1.5161.00
6_R31_V1.5161.00
24_L55_L1.5101.00
49_P57_E1.4931.00
54_V57_E1.4851.00
131_G226_R1.4791.00
215_I248_V1.4771.00
216_D219_L1.4731.00
222_A226_R1.4651.00
224_L282_L1.4531.00
155_L175_L1.4531.00
22_A178_Q1.4461.00
138_T154_K1.4381.00
83_A102_M1.4381.00
22_A181_I1.4261.00
83_A86_M1.4251.00
114_L136_G1.4221.00
266_L281_I1.4191.00
154_K195_E1.4061.00
38_D53_K1.4041.00
164_T232_N1.4031.00
53_K65_Q1.3961.00
53_K57_E1.3941.00
17_A55_L1.3921.00
286_S296_S1.3881.00
273_I297_A1.3511.00
150_D194_P1.3461.00
214_R240_E1.3341.00
225_E253_V1.3311.00
54_V58_E1.3291.00
152_L194_P1.3261.00
7_I85_V1.3211.00
151_M154_K1.3011.00
160_T171_K1.2881.00
214_R238_W1.2851.00
129_W227_C1.2841.00
273_I284_L1.2821.00
72_Q76_Q1.2811.00
260_A264_T1.2791.00
21_D58_E1.2741.00
225_E229_R1.2731.00
8_I32_G1.2691.00
221_A253_V1.2661.00
129_W231_F1.2651.00
19_H180_L1.2641.00
289_P295_M1.2571.00
153_Y183_T1.2541.00
275_V284_L1.2541.00
70_R96_P1.2441.00
239_L248_V1.2431.00
182_T186_Q1.2431.00
141_Q152_L1.2371.00
153_Y186_Q1.2311.00
28_H185_K1.2191.00
26_S181_I1.2191.00
86_M107_C1.2081.00
254_I274_Q1.2001.00
220_S279_D1.1921.00
110_V180_L1.1921.00
64_F81_L1.1791.00
143_D150_D1.1791.00
221_A277_T1.1721.00
114_L154_K1.1691.00
153_Y179_G1.1651.00
12_T50_S1.1621.00
24_L30_V1.1581.00
94_I146_L1.1481.00
135_T159_I1.1351.00
41_A44_G1.1321.00
186_Q192_A1.1321.00
126_R129_W1.1281.00
254_I283_N1.1241.00
126_R130_A1.1181.00
76_Q79_A1.1111.00
246_V287_L1.1061.00
221_A279_D1.0961.00
198_D202_V1.0901.00
162_E225_E1.0881.00
32_G64_F1.0871.00
41_A48_M1.0861.00
153_Y182_T1.0841.00
128_L168_L1.0831.00
117_R203_T1.0831.00
248_V284_L1.0781.00
160_T167_T1.0771.00
84_D104_R1.0761.00
240_E243_G1.0731.00
19_H89_V1.0651.00
34_F74_N1.0581.00
239_L246_V1.0481.00
288_Q294_A1.0481.00
49_P54_V1.0371.00
9_F19_H1.0351.00
121_A207_K1.0161.00
139_I153_Y1.0151.00
159_I163_D1.0131.00
35_T50_S1.0021.00
108_I152_L0.9961.00
300_L304_R0.9881.00
122_A126_R0.9831.00
79_A98_A0.9821.00
31_V81_L0.9701.00
79_A102_M0.9661.00
155_L179_G0.9611.00
28_H188_A0.9601.00
33_V61_L0.9591.00
75_Q98_A0.9591.00
124_I169_Y0.9551.00
217_W275_V0.9501.00
100_L142_M0.9481.00
164_T167_T0.9421.00
185_K188_A0.9391.00
289_P300_L0.9391.00
39_R67_V0.9311.00
161_A222_A0.9271.00
269_N272_G0.9231.00
240_E245_P0.9221.00
209_S212_E0.9191.00
152_L187_L0.9171.00
264_T276_A0.9151.00
103_P107_C0.9101.00
110_V139_I0.9010.99
254_I281_I0.8990.99
64_F77_L0.8990.99
152_L192_A0.8970.99
211_E214_R0.8950.99
226_R229_R0.8910.99
23_L184_L0.8860.99
162_E250_K0.8790.99
107_C142_M0.8780.99
292_K295_M0.8740.99
36_Q39_R0.8720.99
228_I237_S0.8720.99
223_Q226_R0.8710.99
260_A276_A0.8690.99
21_D59_K0.8690.99
232_N249_W0.8680.99
167_T171_K0.8680.99
10_A34_F0.8650.99
133_A158_P0.8640.99
162_E252_S0.8620.99
225_E282_L0.8610.99
69_L74_N0.8580.99
224_L277_T0.8570.99
75_Q99_V0.8570.99
110_V137_V0.8570.99
227_C231_F0.8550.99
74_N77_L0.8530.99
117_R201_L0.8530.99
18_R173_A0.8480.99
10_A86_M0.8470.99
122_A205_A0.8450.99
246_V289_P0.8430.99
5_L188_A0.8410.99
287_L300_L0.8370.99
187_L192_A0.8300.99
218_S278_G0.8250.99
174_E178_Q0.8250.99
44_G48_M0.8230.99
248_V251_A0.8220.99
222_A225_E0.8210.99
26_S185_K0.8110.99
276_A281_I0.8100.99
18_R21_D0.8090.99
161_A225_E0.8090.99
297_A301_L0.8070.99
108_I139_I0.8060.99
126_R205_A0.8050.99
22_A25_S0.8030.99
22_A26_S0.8030.99
163_D168_L0.8030.99
238_W245_P0.8020.99
245_P290_A0.7900.99
13_P90_A0.7900.99
112_G124_I0.7860.99
6_R82_Q0.7860.99
15_F112_G0.7830.99
179_G183_T0.7800.99
262_P276_A0.7790.99
268_A273_I0.7680.98
127_S159_I0.7670.98
38_D65_Q0.7640.98
32_G77_L0.7620.98
25_S59_K0.7620.98
213_A238_W0.7560.98
223_Q227_C0.7550.98
269_N274_Q0.7530.98
175_L179_G0.7500.98
25_S55_L0.7490.98
72_Q75_Q0.7490.98
289_P292_K0.7480.98
34_F64_F0.7480.98
247_K288_Q0.7480.98
69_L75_Q0.7460.98
186_Q189_D0.7450.98
50_S65_Q0.7380.98
85_V106_G0.7370.98
71_P74_N0.7350.98
41_A46_K0.7340.98
244_Q289_P0.7280.98
89_V139_I0.7280.98
126_R206_E0.7230.98
68_S71_P0.7230.98
185_K189_D0.7220.98
86_M103_P0.7180.97
69_L93_L0.7160.97
267_E274_Q0.7120.97
128_L230_A0.7090.97
271_Q298_Q0.7070.97
64_F74_N0.7060.97
24_L61_L0.7050.97
72_Q98_A0.7040.97
135_T168_L0.7020.97
112_G172_L0.7020.97
7_I28_H0.7010.97
73_E76_Q0.7000.97
249_W288_Q0.6990.97
85_V108_I0.6980.97
222_A279_D0.6970.97
258_T276_A0.6970.97
213_A234_W0.6960.97
101_E144_V0.6940.97
258_T281_I0.6930.97
295_M299_D0.6930.97
125_Q234_W0.6870.97
241_I246_V0.6860.97
170_D174_E0.6840.97
108_I180_L0.6840.97
88_V142_M0.6810.97
110_V176_G0.6800.96
139_I179_G0.6800.96
157_C163_D0.6800.96
213_A236_M0.6770.96
78_V99_V0.6760.96
22_A177_P0.6740.96
23_L30_V0.6710.96
8_I34_F0.6690.96
166_G170_D0.6660.96
16_A19_H0.6650.96
83_A103_P0.6600.96
48_M54_V0.6600.96
265_I275_V0.6590.96
130_A206_E0.6550.96
138_T152_L0.6520.96
8_I78_V0.6500.95
255_D280_G0.6500.95
128_L159_I0.6490.95
9_F20_L0.6490.95
8_I86_M0.6490.95
133_A161_A0.6470.95
19_H22_A0.6470.95
19_H177_P0.6470.95
40_P45_K0.6460.95
178_Q182_T0.6460.95
125_Q230_A0.6450.95
100_L107_C0.6400.95
13_P16_A0.6390.95
75_Q79_A0.6390.95
236_M249_W0.6380.95
221_A280_G0.6360.95
164_T250_K0.6340.95
213_A231_F0.6320.95
82_Q104_R0.6320.95
151_M195_E0.6300.95
77_L81_L0.6300.95
141_Q150_D0.6270.94
124_I165_S0.6260.94
66_P91_Y0.6260.94
145_G199_E0.6260.94
222_A253_V0.6260.94
68_S93_L0.6240.94
15_F124_I0.6230.94
137_V175_L0.6180.94
105_L188_A0.6180.94
175_L178_Q0.6140.94
79_A82_Q0.6140.94
20_L33_V0.6130.94
273_I287_L0.6130.94
112_G127_S0.6120.94
68_S74_N0.6120.94
108_I194_P0.6100.94
262_P277_T0.6090.94
277_T281_I0.6090.94
165_S169_Y0.6070.94
106_G141_Q0.6050.93
114_L156_S0.6050.93
89_V176_G0.6030.93
112_G125_Q0.6000.93
287_L297_A0.5960.93
15_F176_G0.5930.93
27_G185_K0.5900.93
289_P304_R0.5900.93
78_V86_M0.5900.93
260_A281_I0.5880.92
5_L28_H0.5860.92
273_I283_N0.5850.92
126_R207_K0.5830.92
266_L276_A0.5820.92
232_N236_M0.5820.92
217_W224_L0.5810.92
36_Q93_L0.5810.92
24_L27_G0.5800.92
98_A101_E0.5770.92
117_R202_V0.5770.92
165_S208_L0.5750.92
127_S132_D0.5710.91
171_K175_L0.5700.91
133_A222_A0.5690.91
93_L96_P0.5690.91
18_R174_E0.5690.91
228_I248_V0.5680.91
33_V56_A0.5680.91
8_I81_L0.5670.91
283_N297_A0.5670.91
69_L99_V0.5660.91
210_K213_A0.5660.91
126_R230_A0.5660.91
232_N294_A0.5640.91
196_V199_E0.5620.91
220_S278_G0.5620.91
127_S135_T0.5620.91
177_P181_I0.5610.91
35_T65_Q0.5570.90
167_T225_E0.5560.90
112_G169_Y0.5560.90
35_T52_V0.5540.90
208_L234_W0.5520.90
49_P53_K0.5500.90
19_H173_A0.5490.90
95_L107_C0.5480.90
67_V71_P0.5470.89
43_R47_L0.5460.89
293_K299_D0.5460.89
225_E228_I0.5440.89
86_M102_M0.5430.89
15_F89_V0.5420.89
44_G47_L0.5420.89
124_I172_L0.5410.89
5_L29_N0.5370.89
138_T143_D0.5360.88
108_I183_T0.5360.88
92_G140_M0.5350.88
68_S75_Q0.5350.88
157_C172_L0.5350.88
268_A301_L0.5330.88
112_G154_K0.5320.88
144_V148_T0.5310.88
16_A112_G0.5310.88
208_L212_E0.5300.88
113_S123_P0.5290.88
34_F69_L0.5290.88
34_F78_V0.5290.88
215_I227_C0.5290.88
15_F110_V0.5280.88
30_V61_L0.5280.88
125_Q208_L0.5270.88
118_W205_A0.5270.88
109_N140_M0.5260.88
139_I180_L0.5260.88
161_A253_V0.5250.87
157_C160_T0.5240.87
167_T250_K0.5230.87
182_T185_K0.5220.87
40_P47_L0.5220.87
166_G232_N0.5210.87
16_A89_V0.5210.87
34_F91_Y0.5200.87
112_G165_S0.5180.87
85_V187_L0.5170.87
237_S251_A0.5160.87
257_A279_D0.5150.86
139_I176_G0.5150.86
272_G297_A0.5140.86
34_F77_L0.5120.86
253_V282_L0.5120.86
256_T260_A0.5110.86
33_V52_V0.5100.86
251_A285_L0.5100.86
165_S230_A0.5090.86
213_A232_N0.5050.85
241_I305_R0.5050.85
131_G222_A0.5040.85
295_M301_L0.5030.85
85_V141_Q0.5030.85
8_I31_V0.5030.85
232_N250_K0.5010.85
5_L84_D0.5010.85
292_K303_S0.5000.85
143_D146_L0.5000.85
125_Q169_Y0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q0iA 1 0.9524 100 0.088 Contact Map
1fmtA 1 0.9714 100 0.09 Contact Map
3tqqA 1 0.9556 100 0.093 Contact Map
4iqfA 1 0.9905 100 0.1 Contact Map
2blnA 1 0.9429 100 0.135 Contact Map
4wkgA 5 0.9524 100 0.15 Contact Map
2bw0A 1 0.9238 100 0.151 Contact Map
4lxqA 2 0.8571 100 0.278 Contact Map
4xczA 2 0.9302 100 0.312 Contact Map
1zghA 1 0.7048 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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