GREMLIN Database
FEPG - Ferric enterobactin transport system permease protein FepG
UniProt: P23877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10298
Length: 330 (318)
Sequences: 13848 (9905)
Seq/√Len: 555.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_A282_A3.7631.00
107_A121_S3.6131.00
22_A291_A3.5441.00
79_I207_A3.4691.00
23_G63_V3.3471.00
230_S233_R3.2351.00
72_A200_I3.0861.00
79_I238_M3.0501.00
67_L286_A2.9861.00
66_A185_L2.8601.00
267_A284_C2.7971.00
38_Q51_M2.7611.00
65_M188_L2.5961.00
72_A245_L2.5241.00
75_V282_A2.5111.00
72_A249_A2.4941.00
23_G67_L2.4791.00
38_Q41_A2.4201.00
102_S161_F2.4061.00
221_D235_R2.3791.00
19_C287_L2.3031.00
69_I249_A2.2521.00
18_A287_L2.2281.00
78_A281_A2.1951.00
75_V204_L2.1861.00
28_R36_T2.1381.00
271_S280_Q2.1281.00
67_L290_L2.0671.00
199_I248_A2.0661.00
69_I253_A2.0631.00
48_P51_M2.0441.00
213_R234_S2.0351.00
215_R274_A2.0221.00
19_C67_L2.0221.00
102_S158_L2.0211.00
35_E38_Q2.0051.00
68_L197_A1.9531.00
26_G63_V1.9421.00
106_V110_L1.9341.00
62_R293_D1.9161.00
80_F242_A1.8821.00
82_S274_A1.8691.00
37_S41_A1.8641.00
22_A287_L1.8511.00
210_L213_R1.8501.00
216_L229_V1.8471.00
105_L162_N1.8031.00
12_C280_Q1.7961.00
206_A241_V1.7861.00
203_M245_L1.7081.00
188_L192_K1.6831.00
52_T56_T1.6651.00
210_L237_L1.6511.00
46_D52_T1.6461.00
49_R52_T1.6441.00
233_R237_L1.5831.00
64_L193_T1.5751.00
259_I289_L1.5651.00
78_A277_G1.5611.00
25_W28_R1.5591.00
295_C299_L1.5581.00
189_T192_K1.5361.00
194_S198_P1.5361.00
203_M244_V1.5261.00
210_L234_S1.5061.00
126_G247_A1.5011.00
104_V122_A1.4981.00
42_A56_T1.4831.00
15_L283_L1.4801.00
296_A307_V1.4571.00
25_W29_S1.4521.00
19_C283_L1.4391.00
103_G121_S1.4331.00
22_A290_L1.4331.00
185_L289_L1.4091.00
130_S243_V1.3921.00
11_T280_Q1.3901.00
40_F44_M1.3721.00
203_M241_V1.3671.00
295_C310_V1.3591.00
267_A280_Q1.3521.00
15_L280_Q1.3511.00
76_S245_L1.3421.00
276_W279_T1.3381.00
26_G294_L1.3341.00
206_A210_L1.2831.00
129_T158_L1.2821.00
157_M316_G1.2801.00
65_M252_L1.2801.00
15_L284_C1.2791.00
101_W162_N1.2751.00
267_A277_G1.2721.00
198_P202_L1.2661.00
194_S197_A1.2651.00
210_L238_M1.2631.00
19_C286_A1.2521.00
97_N246_T1.2481.00
68_L193_T1.2381.00
103_G125_G1.2371.00
263_A288_L1.2341.00
263_A284_C1.2261.00
225_C232_E1.2211.00
53_M57_E1.2151.00
74_G263_A1.2071.00
15_L287_L1.2021.00
12_C276_W1.1991.00
223_T226_A1.1981.00
233_R236_L1.1811.00
33_T36_T1.1811.00
196_S252_L1.1791.00
216_L227_L1.1731.00
274_A277_G1.1731.00
121_S125_G1.1641.00
83_L238_M1.1571.00
101_W181_N1.1541.00
42_A52_T1.1541.00
253_A256_I1.1521.00
234_S237_L1.1441.00
50_S53_M1.1421.00
105_L177_A1.1311.00
66_A290_L1.1291.00
232_E235_R1.1201.00
32_V54_V1.1111.00
205_I209_L1.1081.00
78_A278_L1.1031.00
207_A241_V1.1001.00
71_A286_A1.0981.00
131_L135_L1.0971.00
102_S106_V1.0811.00
66_A289_L1.0791.00
68_L196_S1.0791.00
120_L124_V1.0781.00
99_G129_T1.0761.00
71_A74_G1.0751.00
10_I13_L1.0721.00
206_A237_L1.0681.00
65_M193_T1.0661.00
109_V165_L1.0641.00
220_G224_A1.0621.00
114_D117_A1.0611.00
78_A274_A1.0571.00
46_D56_T1.0571.00
232_E236_L1.0551.00
297_Q304_Q1.0551.00
138_W232_E1.0531.00
155_R159_V1.0531.00
279_T282_A1.0511.00
99_G125_G1.0471.00
28_R39_V1.0321.00
64_L190_W1.0321.00
133_V154_V1.0281.00
196_S200_I1.0171.00
123_M244_V1.0081.00
47_A52_T1.0061.00
98_T158_L1.0061.00
295_C298_Q1.0041.00
164_W168_K1.0021.00
29_S298_Q1.0011.00
296_A310_V0.9951.00
42_A55_V0.9941.00
271_S276_W0.9911.00
128_V132_L0.9911.00
171_L175_L0.9841.00
23_G290_L0.9811.00
17_S21_V0.9811.00
24_I28_R0.9781.00
293_D297_Q0.9781.00
214_M238_M0.9771.00
42_A47_A0.9771.00
42_A46_D0.9761.00
56_T60_L0.9741.00
287_L291_A0.9741.00
202_L205_I0.9741.00
16_V20_V0.9701.00
256_I289_L0.9671.00
263_A267_A0.9611.00
203_M248_A0.9601.00
22_A294_L0.9591.00
97_N255_P0.9591.00
234_S238_M0.9581.00
106_V165_L0.9521.00
277_G281_A0.9511.00
39_V55_V0.9491.00
195_P198_P0.9461.00
42_A51_M0.9441.00
27_L63_V0.9401.00
63_V294_L0.9401.00
198_P201_I0.9331.00
317_I321_V0.9301.00
41_A45_G0.9241.00
276_W280_Q0.9181.00
312_V317_I0.9171.00
68_L200_I0.9051.00
190_W193_T0.9041.00
118_I121_S0.9021.00
170_S173_T0.9001.00
102_S162_N0.8991.00
30_G59_R0.8991.00
249_A253_A0.8961.00
300_F303_Y0.8881.00
129_T133_V0.8841.00
215_R275_R0.8811.00
16_V283_L0.8801.00
52_T57_E0.8791.00
41_A46_D0.8751.00
222_D225_C0.8751.00
96_F126_G0.8741.00
229_V234_S0.8701.00
11_T14_L0.8661.00
71_A204_L0.8651.00
10_I14_L0.8631.00
291_A295_C0.8621.00
270_I284_C0.8611.00
11_T15_L0.8561.00
41_A44_M0.8541.00
236_L240_L0.8531.00
177_A181_N0.8521.00
221_D225_C0.8501.00
274_A279_T0.8491.00
318_Y321_V0.8491.00
135_L138_W0.8481.00
20_V24_I0.8441.00
77_G264_P0.8371.00
76_S242_A0.8311.00
34_L55_V0.8311.00
24_I36_T0.8301.00
211_V275_R0.8291.00
102_S165_L0.8281.00
296_A306_P0.8261.00
104_V118_I0.8261.00
92_D97_N0.8161.00
63_V290_L0.8151.00
138_W141_G0.8131.00
268_R277_G0.8051.00
123_M127_I0.8021.00
231_V235_R0.8011.00
298_Q301_M0.7991.00
206_A209_L0.7971.00
72_A76_S0.7961.00
107_A118_I0.7921.00
19_C23_G0.7911.00
210_L241_V0.7901.00
172_E176_T0.7881.00
221_D231_V0.7881.00
108_M118_I0.7851.00
117_A120_L0.7831.00
239_M243_V0.7831.00
192_K252_L0.7771.00
100_A126_G0.7751.00
60_L190_W0.7741.00
118_I122_A0.7731.00
201_I205_I0.7731.00
215_R279_T0.7731.00
191_A194_S0.7721.00
207_A238_M0.7711.00
49_R53_M0.7691.00
28_R33_T0.7691.00
224_A231_V0.7681.00
299_L302_P0.7661.00
134_W236_L0.7661.00
138_W142_I0.7631.00
200_I249_A0.7621.00
80_F94_M0.7611.00
175_L178_G0.7601.00
74_G78_A0.7591.00
267_A271_S0.7581.00
29_S33_T0.7581.00
283_L287_L0.7531.00
300_F305_L0.7531.00
71_A200_I0.7521.00
62_R297_Q0.7501.00
90_S93_V0.7491.00
62_R304_Q0.7461.00
313_S317_I0.7421.00
199_I203_M0.7401.00
99_G158_L0.7401.00
267_A270_I0.7371.00
289_L311_T0.7371.00
259_I311_T0.7371.00
106_V111_F0.7311.00
21_V24_I0.7291.00
109_V169_A0.7281.00
98_T101_W0.7281.00
96_F130_S0.7281.00
171_L174_A0.7271.00
26_G297_Q0.7251.00
20_V23_G0.7241.00
209_L213_R0.7211.00
65_M196_S0.7211.00
32_V36_T0.7211.00
208_A211_V0.7171.00
34_L51_M0.7161.00
45_G52_T0.7141.00
19_C290_L0.7141.00
106_V161_F0.7121.00
53_M56_T0.7091.00
133_V137_A0.7061.00
269_R322_L0.7051.00
75_V207_A0.7021.00
64_L68_L0.7011.00
196_S248_A0.7001.00
84_M148_I0.6981.00
213_R229_V0.6961.00
321_V325_Q0.6961.00
126_G243_V0.6961.00
75_V278_L0.6961.00
127_I247_A0.6951.00
134_W232_E0.6941.00
32_V35_E0.6941.00
74_G282_A0.6931.00
105_L166_L0.6921.00
130_S134_W0.6891.00
286_A290_L0.6891.00
248_A251_A0.6871.00
124_V128_V0.6871.00
48_P52_T0.6861.00
41_A47_A0.6841.00
125_G129_T0.6831.00
53_M58_W0.6821.00
39_V42_A0.6781.00
204_L208_A0.6771.00
217_L231_V0.6751.00
27_L55_V0.6741.00
266_I284_C0.6731.00
248_A252_L0.6701.00
76_S246_T0.6691.00
256_I307_V0.6681.00
185_L307_V0.6671.00
225_C231_V0.6671.00
101_W255_P0.6661.00
73_L259_I0.6641.00
289_L307_V0.6621.00
27_L60_L0.6621.00
130_S239_M0.6601.00
197_A201_I0.6601.00
199_I244_V0.6601.00
264_P281_A0.6571.00
212_R215_R0.6571.00
266_I269_R0.6551.00
116_T120_L0.6541.00
143_D146_R0.6541.00
196_S199_I0.6491.00
82_S218_E0.6491.00
163_T180_W0.6471.00
169_A174_A0.6421.00
262_V319_L0.6391.00
15_L19_C0.6391.00
288_L292_A0.6371.00
169_A173_T0.6371.00
190_W194_S0.6361.00
36_T39_V0.6361.00
159_V181_N0.6351.00
60_L64_L0.6351.00
69_I185_L0.6351.00
266_I288_L0.6321.00
108_M176_T0.6321.00
292_A310_V0.6291.00
282_A286_A0.6281.00
178_G181_N0.6261.00
166_L178_G0.6261.00
124_V127_I0.6231.00
203_M207_A0.6231.00
37_S40_F0.6231.00
23_G27_L0.6231.00
259_I288_L0.6211.00
90_S260_A0.6211.00
173_T176_T0.6201.00
97_N100_A0.6171.00
136_L150_I0.6161.00
98_T155_R0.6161.00
14_L18_A0.6131.00
246_T250_T0.6091.00
132_L135_L0.6081.00
272_G279_T0.6081.00
163_T167_L0.6061.00
55_V60_L0.6061.00
159_V163_T0.6051.00
288_L314_L0.6051.00
79_I241_V0.6041.00
127_I243_V0.6041.00
103_G107_A0.6031.00
108_M177_A0.6031.00
237_L241_V0.6021.00
262_V266_I0.6011.00
200_I204_L0.6001.00
36_T40_F0.5991.00
11_T270_I0.5981.00
145_F148_I0.5951.00
34_L42_A0.5921.00
84_M87_P0.5921.00
291_A294_L0.5911.00
261_L322_L0.5911.00
107_A117_A0.5911.00
202_L206_A0.5901.00
29_S294_L0.5891.00
35_E51_M0.5891.00
38_Q47_A0.5881.00
137_A150_I0.5861.00
150_I153_G0.5851.00
185_L253_A0.5841.00
12_C16_V0.5831.00
213_R216_L0.5821.00
71_A75_V0.5791.00
24_I40_F0.5780.99
279_T283_L0.5770.99
324_I327_S0.5770.99
296_A304_Q0.5770.99
275_R279_T0.5760.99
11_T271_S0.5760.99
80_F89_G0.5740.99
66_A307_V0.5730.99
39_V44_M0.5720.99
238_M242_A0.5720.99
293_D304_Q0.5720.99
217_L234_S0.5710.99
262_V318_Y0.5700.99
26_G290_L0.5690.99
98_T159_V0.5690.99
209_L212_R0.5680.99
22_A25_W0.5680.99
21_V25_W0.5660.99
215_R218_E0.5650.99
47_A51_M0.5640.99
107_A111_F0.5620.99
266_I318_Y0.5620.99
207_A278_L0.5610.99
65_M69_I0.5610.99
140_N146_R0.5550.99
80_F96_F0.5530.99
247_A251_A0.5500.99
12_C283_L0.5500.99
85_R221_D0.5500.99
137_A147_L0.5500.99
99_G154_V0.5490.99
191_A195_P0.5470.99
28_R40_F0.5470.99
230_S237_L0.5450.99
128_V131_L0.5430.99
195_P199_I0.5410.99
296_A299_L0.5380.99
166_L181_N0.5350.99
142_I146_R0.5340.99
237_L240_L0.5330.99
243_V247_A0.5320.99
39_V43_L0.5320.99
13_L17_S0.5290.99
43_L55_V0.5290.99
290_L294_L0.5290.99
193_T197_A0.5280.99
115_L119_A0.5280.99
96_F133_V0.5260.99
267_A281_A0.5240.99
25_W294_L0.5210.99
38_Q45_G0.5210.99
166_L174_A0.5200.99
294_L298_Q0.5200.99
78_A267_A0.5190.99
14_L17_S0.5180.99
79_I242_A0.5180.99
100_A122_A0.5170.99
129_T154_V0.5170.99
19_C63_V0.5160.99
31_A302_P0.5160.99
321_V324_I0.5140.99
110_L113_Q0.5110.99
230_S236_L0.5110.99
284_C287_L0.5100.99
89_G96_F0.5090.99
96_F184_S0.5070.99
134_W138_W0.5070.99
74_G285_G0.5070.99
207_A211_V0.5060.99
193_T196_S0.5060.99
166_L177_A0.5050.99
104_V121_S0.5050.99
85_R220_G0.5050.99
160_A312_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9303 100 0.176 Contact Map
4g1uA 2 0.8939 100 0.179 Contact Map
2qi9A 2 0.9545 100 0.185 Contact Map
2xq2A 2 0.6848 23.5 0.964 Contact Map
3dh4A 3 0.6121 15.7 0.967 Contact Map
3rlbA 1 0.5152 15.6 0.967 Contact Map
2m20A 2 0.0909 12.1 0.968 Contact Map
4hzuS 1 0.4879 10.1 0.969 Contact Map
1zcdA 1 0.497 9.5 0.97 Contact Map
2l9uA 2 0.0879 7.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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