FEPG - ECOLI - GREMLIN Contacts

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FEPG - Ferric enterobactin transport system permease protein FepG

UniProt:	P23877	Sequences: MIYVSRRLLITCLLLVSACVVAGIWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIALSAMVGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLMMLVAVVLTAAATALAGPISFIALVAPHIARRISGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQESRKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10298
Length:	330 (318)
Sequences:	13848 (9905)
Seq/√Len:	555.4

ECOLI - FEPG FEPD FECC BTUC FECD FHUB
BACSU - FHUG FHUB YVRB YFHA YFIZ YFMD YFME FEUB FEUC YCLN YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_A	282_A	3.763	1.00
107_A	121_S	3.613	1.00
22_A	291_A	3.544	1.00
79_I	207_A	3.469	1.00
23_G	63_V	3.347	1.00
230_S	233_R	3.235	1.00
72_A	200_I	3.086	1.00
79_I	238_M	3.050	1.00
67_L	286_A	2.986	1.00
66_A	185_L	2.860	1.00
267_A	284_C	2.797	1.00
38_Q	51_M	2.761	1.00
65_M	188_L	2.596	1.00
72_A	245_L	2.524	1.00
75_V	282_A	2.511	1.00
72_A	249_A	2.494	1.00
23_G	67_L	2.479	1.00
38_Q	41_A	2.420	1.00
102_S	161_F	2.406	1.00
221_D	235_R	2.379	1.00
19_C	287_L	2.303	1.00
69_I	249_A	2.252	1.00
18_A	287_L	2.228	1.00
78_A	281_A	2.195	1.00
75_V	204_L	2.186	1.00
28_R	36_T	2.138	1.00
271_S	280_Q	2.128	1.00
67_L	290_L	2.067	1.00
199_I	248_A	2.066	1.00
69_I	253_A	2.063	1.00
48_P	51_M	2.044	1.00
213_R	234_S	2.035	1.00
215_R	274_A	2.022	1.00
19_C	67_L	2.022	1.00
102_S	158_L	2.021	1.00
35_E	38_Q	2.005	1.00
68_L	197_A	1.953	1.00
26_G	63_V	1.942	1.00
106_V	110_L	1.934	1.00
62_R	293_D	1.916	1.00
80_F	242_A	1.882	1.00
82_S	274_A	1.869	1.00
37_S	41_A	1.864	1.00
22_A	287_L	1.851	1.00
210_L	213_R	1.850	1.00
216_L	229_V	1.847	1.00
105_L	162_N	1.803	1.00
12_C	280_Q	1.796	1.00
206_A	241_V	1.786	1.00
203_M	245_L	1.708	1.00
188_L	192_K	1.683	1.00
52_T	56_T	1.665	1.00
210_L	237_L	1.651	1.00
46_D	52_T	1.646	1.00
49_R	52_T	1.644	1.00
233_R	237_L	1.583	1.00
64_L	193_T	1.575	1.00
259_I	289_L	1.565	1.00
78_A	277_G	1.561	1.00
25_W	28_R	1.559	1.00
295_C	299_L	1.558	1.00
189_T	192_K	1.536	1.00
194_S	198_P	1.536	1.00
203_M	244_V	1.526	1.00
210_L	234_S	1.506	1.00
126_G	247_A	1.501	1.00
104_V	122_A	1.498	1.00
42_A	56_T	1.483	1.00
15_L	283_L	1.480	1.00
296_A	307_V	1.457	1.00
25_W	29_S	1.452	1.00
19_C	283_L	1.439	1.00
103_G	121_S	1.433	1.00
22_A	290_L	1.433	1.00
185_L	289_L	1.409	1.00
130_S	243_V	1.392	1.00
11_T	280_Q	1.390	1.00
40_F	44_M	1.372	1.00
203_M	241_V	1.367	1.00
295_C	310_V	1.359	1.00
267_A	280_Q	1.352	1.00
15_L	280_Q	1.351	1.00
76_S	245_L	1.342	1.00
276_W	279_T	1.338	1.00
26_G	294_L	1.334	1.00
206_A	210_L	1.283	1.00
129_T	158_L	1.282	1.00
157_M	316_G	1.280	1.00
65_M	252_L	1.280	1.00
15_L	284_C	1.279	1.00
101_W	162_N	1.275	1.00
267_A	277_G	1.272	1.00
198_P	202_L	1.266	1.00
194_S	197_A	1.265	1.00
210_L	238_M	1.263	1.00
19_C	286_A	1.252	1.00
97_N	246_T	1.248	1.00
68_L	193_T	1.238	1.00
103_G	125_G	1.237	1.00
263_A	288_L	1.234	1.00
263_A	284_C	1.226	1.00
225_C	232_E	1.221	1.00
53_M	57_E	1.215	1.00
74_G	263_A	1.207	1.00
15_L	287_L	1.202	1.00
12_C	276_W	1.199	1.00
223_T	226_A	1.198	1.00
233_R	236_L	1.181	1.00
33_T	36_T	1.181	1.00
196_S	252_L	1.179	1.00
216_L	227_L	1.173	1.00
274_A	277_G	1.173	1.00
121_S	125_G	1.164	1.00
83_L	238_M	1.157	1.00
101_W	181_N	1.154	1.00
42_A	52_T	1.154	1.00
253_A	256_I	1.152	1.00
234_S	237_L	1.144	1.00
50_S	53_M	1.142	1.00
105_L	177_A	1.131	1.00
66_A	290_L	1.129	1.00
232_E	235_R	1.120	1.00
32_V	54_V	1.111	1.00
205_I	209_L	1.108	1.00
78_A	278_L	1.103	1.00
207_A	241_V	1.100	1.00
71_A	286_A	1.098	1.00
131_L	135_L	1.097	1.00
102_S	106_V	1.081	1.00
66_A	289_L	1.079	1.00
68_L	196_S	1.079	1.00
120_L	124_V	1.078	1.00
99_G	129_T	1.076	1.00
71_A	74_G	1.075	1.00
10_I	13_L	1.072	1.00
206_A	237_L	1.068	1.00
65_M	193_T	1.066	1.00
109_V	165_L	1.064	1.00
220_G	224_A	1.062	1.00
114_D	117_A	1.061	1.00
78_A	274_A	1.057	1.00
46_D	56_T	1.057	1.00
232_E	236_L	1.055	1.00
297_Q	304_Q	1.055	1.00
138_W	232_E	1.053	1.00
155_R	159_V	1.053	1.00
279_T	282_A	1.051	1.00
99_G	125_G	1.047	1.00
28_R	39_V	1.032	1.00
64_L	190_W	1.032	1.00
133_V	154_V	1.028	1.00
196_S	200_I	1.017	1.00
123_M	244_V	1.008	1.00
47_A	52_T	1.006	1.00
98_T	158_L	1.006	1.00
295_C	298_Q	1.004	1.00
164_W	168_K	1.002	1.00
29_S	298_Q	1.001	1.00
296_A	310_V	0.995	1.00
42_A	55_V	0.994	1.00
271_S	276_W	0.991	1.00
128_V	132_L	0.991	1.00
171_L	175_L	0.984	1.00
23_G	290_L	0.981	1.00
17_S	21_V	0.981	1.00
24_I	28_R	0.978	1.00
293_D	297_Q	0.978	1.00
214_M	238_M	0.977	1.00
42_A	47_A	0.977	1.00
42_A	46_D	0.976	1.00
56_T	60_L	0.974	1.00
287_L	291_A	0.974	1.00
202_L	205_I	0.974	1.00
16_V	20_V	0.970	1.00
256_I	289_L	0.967	1.00
263_A	267_A	0.961	1.00
203_M	248_A	0.960	1.00
22_A	294_L	0.959	1.00
97_N	255_P	0.959	1.00
234_S	238_M	0.958	1.00
106_V	165_L	0.952	1.00
277_G	281_A	0.951	1.00
39_V	55_V	0.949	1.00
195_P	198_P	0.946	1.00
42_A	51_M	0.944	1.00
27_L	63_V	0.940	1.00
63_V	294_L	0.940	1.00
198_P	201_I	0.933	1.00
317_I	321_V	0.930	1.00
41_A	45_G	0.924	1.00
276_W	280_Q	0.918	1.00
312_V	317_I	0.917	1.00
68_L	200_I	0.905	1.00
190_W	193_T	0.904	1.00
118_I	121_S	0.902	1.00
170_S	173_T	0.900	1.00
102_S	162_N	0.899	1.00
30_G	59_R	0.899	1.00
249_A	253_A	0.896	1.00
300_F	303_Y	0.888	1.00
129_T	133_V	0.884	1.00
215_R	275_R	0.881	1.00
16_V	283_L	0.880	1.00
52_T	57_E	0.879	1.00
41_A	46_D	0.875	1.00
222_D	225_C	0.875	1.00
96_F	126_G	0.874	1.00
229_V	234_S	0.870	1.00
11_T	14_L	0.866	1.00
71_A	204_L	0.865	1.00
10_I	14_L	0.863	1.00
291_A	295_C	0.862	1.00
270_I	284_C	0.861	1.00
11_T	15_L	0.856	1.00
41_A	44_M	0.854	1.00
236_L	240_L	0.853	1.00
177_A	181_N	0.852	1.00
221_D	225_C	0.850	1.00
274_A	279_T	0.849	1.00
318_Y	321_V	0.849	1.00
135_L	138_W	0.848	1.00
20_V	24_I	0.844	1.00
77_G	264_P	0.837	1.00
76_S	242_A	0.831	1.00
34_L	55_V	0.831	1.00
24_I	36_T	0.830	1.00
211_V	275_R	0.829	1.00
102_S	165_L	0.828	1.00
296_A	306_P	0.826	1.00
104_V	118_I	0.826	1.00
92_D	97_N	0.816	1.00
63_V	290_L	0.815	1.00
138_W	141_G	0.813	1.00
268_R	277_G	0.805	1.00
123_M	127_I	0.802	1.00
231_V	235_R	0.801	1.00
298_Q	301_M	0.799	1.00
206_A	209_L	0.797	1.00
72_A	76_S	0.796	1.00
107_A	118_I	0.792	1.00
19_C	23_G	0.791	1.00
210_L	241_V	0.790	1.00
172_E	176_T	0.788	1.00
221_D	231_V	0.788	1.00
108_M	118_I	0.785	1.00
117_A	120_L	0.783	1.00
239_M	243_V	0.783	1.00
192_K	252_L	0.777	1.00
100_A	126_G	0.775	1.00
60_L	190_W	0.774	1.00
118_I	122_A	0.773	1.00
201_I	205_I	0.773	1.00
215_R	279_T	0.773	1.00
191_A	194_S	0.772	1.00
207_A	238_M	0.771	1.00
49_R	53_M	0.769	1.00
28_R	33_T	0.769	1.00
224_A	231_V	0.768	1.00
299_L	302_P	0.766	1.00
134_W	236_L	0.766	1.00
138_W	142_I	0.763	1.00
200_I	249_A	0.762	1.00
80_F	94_M	0.761	1.00
175_L	178_G	0.760	1.00
74_G	78_A	0.759	1.00
267_A	271_S	0.758	1.00
29_S	33_T	0.758	1.00
283_L	287_L	0.753	1.00
300_F	305_L	0.753	1.00
71_A	200_I	0.752	1.00
62_R	297_Q	0.750	1.00
90_S	93_V	0.749	1.00
62_R	304_Q	0.746	1.00
313_S	317_I	0.742	1.00
199_I	203_M	0.740	1.00
99_G	158_L	0.740	1.00
267_A	270_I	0.737	1.00
289_L	311_T	0.737	1.00
259_I	311_T	0.737	1.00
106_V	111_F	0.731	1.00
21_V	24_I	0.729	1.00
109_V	169_A	0.728	1.00
98_T	101_W	0.728	1.00
96_F	130_S	0.728	1.00
171_L	174_A	0.727	1.00
26_G	297_Q	0.725	1.00
20_V	23_G	0.724	1.00
209_L	213_R	0.721	1.00
65_M	196_S	0.721	1.00
32_V	36_T	0.721	1.00
208_A	211_V	0.717	1.00
34_L	51_M	0.716	1.00
45_G	52_T	0.714	1.00
19_C	290_L	0.714	1.00
106_V	161_F	0.712	1.00
53_M	56_T	0.709	1.00
133_V	137_A	0.706	1.00
269_R	322_L	0.705	1.00
75_V	207_A	0.702	1.00
64_L	68_L	0.701	1.00
196_S	248_A	0.700	1.00
84_M	148_I	0.698	1.00
213_R	229_V	0.696	1.00
321_V	325_Q	0.696	1.00
126_G	243_V	0.696	1.00
75_V	278_L	0.696	1.00
127_I	247_A	0.695	1.00
134_W	232_E	0.694	1.00
32_V	35_E	0.694	1.00
74_G	282_A	0.693	1.00
105_L	166_L	0.692	1.00
130_S	134_W	0.689	1.00
286_A	290_L	0.689	1.00
248_A	251_A	0.687	1.00
124_V	128_V	0.687	1.00
48_P	52_T	0.686	1.00
41_A	47_A	0.684	1.00
125_G	129_T	0.683	1.00
53_M	58_W	0.682	1.00
39_V	42_A	0.678	1.00
204_L	208_A	0.677	1.00
217_L	231_V	0.675	1.00
27_L	55_V	0.674	1.00
266_I	284_C	0.673	1.00
248_A	252_L	0.670	1.00
76_S	246_T	0.669	1.00
256_I	307_V	0.668	1.00
185_L	307_V	0.667	1.00
225_C	231_V	0.667	1.00
101_W	255_P	0.666	1.00
73_L	259_I	0.664	1.00
289_L	307_V	0.662	1.00
27_L	60_L	0.662	1.00
130_S	239_M	0.660	1.00
197_A	201_I	0.660	1.00
199_I	244_V	0.660	1.00
264_P	281_A	0.657	1.00
212_R	215_R	0.657	1.00
266_I	269_R	0.655	1.00
116_T	120_L	0.654	1.00
143_D	146_R	0.654	1.00
196_S	199_I	0.649	1.00
82_S	218_E	0.649	1.00
163_T	180_W	0.647	1.00
169_A	174_A	0.642	1.00
262_V	319_L	0.639	1.00
15_L	19_C	0.639	1.00
288_L	292_A	0.637	1.00
169_A	173_T	0.637	1.00
190_W	194_S	0.636	1.00
36_T	39_V	0.636	1.00
159_V	181_N	0.635	1.00
60_L	64_L	0.635	1.00
69_I	185_L	0.635	1.00
266_I	288_L	0.632	1.00
108_M	176_T	0.632	1.00
292_A	310_V	0.629	1.00
282_A	286_A	0.628	1.00
178_G	181_N	0.626	1.00
166_L	178_G	0.626	1.00
124_V	127_I	0.623	1.00
203_M	207_A	0.623	1.00
37_S	40_F	0.623	1.00
23_G	27_L	0.623	1.00
259_I	288_L	0.621	1.00
90_S	260_A	0.621	1.00
173_T	176_T	0.620	1.00
97_N	100_A	0.617	1.00
136_L	150_I	0.616	1.00
98_T	155_R	0.616	1.00
14_L	18_A	0.613	1.00
246_T	250_T	0.609	1.00
132_L	135_L	0.608	1.00
272_G	279_T	0.608	1.00
163_T	167_L	0.606	1.00
55_V	60_L	0.606	1.00
159_V	163_T	0.605	1.00
288_L	314_L	0.605	1.00
79_I	241_V	0.604	1.00
127_I	243_V	0.604	1.00
103_G	107_A	0.603	1.00
108_M	177_A	0.603	1.00
237_L	241_V	0.602	1.00
262_V	266_I	0.601	1.00
200_I	204_L	0.600	1.00
36_T	40_F	0.599	1.00
11_T	270_I	0.598	1.00
145_F	148_I	0.595	1.00
34_L	42_A	0.592	1.00
84_M	87_P	0.592	1.00
291_A	294_L	0.591	1.00
261_L	322_L	0.591	1.00
107_A	117_A	0.591	1.00
202_L	206_A	0.590	1.00
29_S	294_L	0.589	1.00
35_E	51_M	0.589	1.00
38_Q	47_A	0.588	1.00
137_A	150_I	0.586	1.00
150_I	153_G	0.585	1.00
185_L	253_A	0.584	1.00
12_C	16_V	0.583	1.00
213_R	216_L	0.582	1.00
71_A	75_V	0.579	1.00
24_I	40_F	0.578	0.99
279_T	283_L	0.577	0.99
324_I	327_S	0.577	0.99
296_A	304_Q	0.577	0.99
275_R	279_T	0.576	0.99
11_T	271_S	0.576	0.99
80_F	89_G	0.574	0.99
66_A	307_V	0.573	0.99
39_V	44_M	0.572	0.99
238_M	242_A	0.572	0.99
293_D	304_Q	0.572	0.99
217_L	234_S	0.571	0.99
262_V	318_Y	0.570	0.99
26_G	290_L	0.569	0.99
98_T	159_V	0.569	0.99
209_L	212_R	0.568	0.99
22_A	25_W	0.568	0.99
21_V	25_W	0.566	0.99
215_R	218_E	0.565	0.99
47_A	51_M	0.564	0.99
107_A	111_F	0.562	0.99
266_I	318_Y	0.562	0.99
207_A	278_L	0.561	0.99
65_M	69_I	0.561	0.99
140_N	146_R	0.555	0.99
80_F	96_F	0.553	0.99
247_A	251_A	0.550	0.99
12_C	283_L	0.550	0.99
85_R	221_D	0.550	0.99
137_A	147_L	0.550	0.99
99_G	154_V	0.549	0.99
191_A	195_P	0.547	0.99
28_R	40_F	0.547	0.99
230_S	237_L	0.545	0.99
128_V	131_L	0.543	0.99
195_P	199_I	0.541	0.99
296_A	299_L	0.538	0.99
166_L	181_N	0.535	0.99
142_I	146_R	0.534	0.99
237_L	240_L	0.533	0.99
243_V	247_A	0.532	0.99
39_V	43_L	0.532	0.99
13_L	17_S	0.529	0.99
43_L	55_V	0.529	0.99
290_L	294_L	0.529	0.99
193_T	197_A	0.528	0.99
115_L	119_A	0.528	0.99
96_F	133_V	0.526	0.99
267_A	281_A	0.524	0.99
25_W	294_L	0.521	0.99
38_Q	45_G	0.521	0.99
166_L	174_A	0.520	0.99
294_L	298_Q	0.520	0.99
78_A	267_A	0.519	0.99
14_L	17_S	0.518	0.99
79_I	242_A	0.518	0.99
100_A	122_A	0.517	0.99
129_T	154_V	0.517	0.99
19_C	63_V	0.516	0.99
31_A	302_P	0.516	0.99
321_V	324_I	0.514	0.99
110_L	113_Q	0.511	0.99
230_S	236_L	0.511	0.99
284_C	287_L	0.510	0.99
89_G	96_F	0.509	0.99
96_F	184_S	0.507	0.99
134_W	138_W	0.507	0.99
74_G	285_G	0.507	0.99
207_A	211_V	0.506	0.99
193_T	196_S	0.506	0.99
166_L	177_A	0.505	0.99
104_V	121_S	0.505	0.99
85_R	220_G	0.505	0.99
160_A	312_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9303	100	0.176	Contact Map
4g1uA	2	0.8939	100	0.179	Contact Map
2qi9A	2	0.9545	100	0.185	Contact Map
2xq2A	2	0.6848	23.5	0.964	Contact Map
3dh4A	3	0.6121	15.7	0.967	Contact Map
3rlbA	1	0.5152	15.6	0.967	Contact Map
2m20A	2	0.0909	12.1	0.968	Contact Map
4hzuS	1	0.4879	10.1	0.969	Contact Map
1zcdA	1	0.497	9.5	0.97	Contact Map
2l9uA	2	0.0879	7.7	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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