FEPD - ECOLI - GREMLIN Contacts

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FEPD - Ferric enterobactin transport system permease protein FepD

UniProt:	P23876	Sequences: MSGSVAVTRAIAVPGLLLLLIIATALSLLIGAKSLPASVVLEAFSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAIVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRVIVPGELRVSVVSAFIGAPVLIFLVRRKTRGGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10296
Length:	334 (318)
Sequences:	13884 (9922)
Seq/√Len:	556.4

ECOLI - FEPD FEPG FECC BTUC FECD FHUB
BACSU - FHUB FHUG YVRB YFIZ YFME YFMD YFHA FEUB FEUC YCLN YCLO
HALSA - Q9HMG0 BTUCA Q9HMG7
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_N	277_D	4.442	1.00
72_G	286_L	3.755	1.00
108_G	123_M	3.630	1.00
23_A	295_F	3.546	1.00
80_L	210_A	3.478	1.00
24_T	64_T	3.337	1.00
233_R	236_R	3.239	1.00
73_A	203_V	3.111	1.00
80_L	241_G	3.055	1.00
68_L	290_P	2.978	1.00
67_G	188_L	2.888	1.00
270_A	288_A	2.781	1.00
39_V	52_D	2.741	1.00
66_A	191_R	2.576	1.00
76_L	286_L	2.530	1.00
73_A	248_L	2.521	1.00
73_A	252_A	2.507	1.00
24_T	68_L	2.462	1.00
39_V	42_E	2.446	1.00
103_F	165_L	2.398	1.00
224_S	238_Q	2.371	1.00
20_L	291_A	2.324	1.00
19_L	291_A	2.267	1.00
70_A	252_A	2.258	1.00
76_L	207_G	2.197	1.00
79_A	285_T	2.188	1.00
274_V	284_V	2.144	1.00
29_L	37_A	2.115	1.00
68_L	294_L	2.052	1.00
202_P	251_S	2.045	1.00
70_A	256_V	2.040	1.00
49_Q	52_D	2.039	1.00
20_L	68_L	2.031	1.00
103_F	162_L	2.028	1.00
216_A	237_T	2.006	1.00
36_P	39_V	1.994	1.00
69_L	200_L	1.928	1.00
63_R	297_D	1.926	1.00
107_L	111_L	1.908	1.00
27_S	64_T	1.905	1.00
218_N	278_H	1.861	1.00
81_M	245_I	1.849	1.00
83_T	278_H	1.847	1.00
213_L	216_A	1.836	1.00
219_S	232_S	1.822	1.00
106_V	166_T	1.808	1.00
38_S	42_E	1.808	1.00
23_A	291_A	1.798	1.00
13_V	284_V	1.774	1.00
209_T	244_A	1.765	1.00
191_R	195_T	1.695	1.00
53_C	57_L	1.694	1.00
206_A	248_L	1.692	1.00
50_S	53_C	1.639	1.00
213_L	240_I	1.637	1.00
236_R	240_I	1.610	1.00
47_T	53_C	1.595	1.00
299_I	303_I	1.579	1.00
79_A	281_S	1.574	1.00
65_L	196_L	1.545	1.00
262_I	293_L	1.541	1.00
105_I	124_A	1.525	1.00
26_L	29_L	1.520	1.00
132_S	246_T	1.515	1.00
192_N	195_T	1.515	1.00
20_L	287_L	1.507	1.00
206_A	247_V	1.503	1.00
16_L	287_L	1.496	1.00
197_K	201_I	1.496	1.00
43_A	57_L	1.493	1.00
213_L	237_T	1.493	1.00
128_A	250_G	1.493	1.00
300_G	310_V	1.480	1.00
104_A	123_M	1.465	1.00
26_L	30_I	1.437	1.00
23_A	294_L	1.433	1.00
188_L	293_L	1.411	1.00
12_A	284_V	1.407	1.00
206_A	244_A	1.369	1.00
41_L	45_S	1.367	1.00
16_L	284_V	1.356	1.00
77_A	248_L	1.354	1.00
299_I	313_V	1.352	1.00
27_S	298_I	1.342	1.00
280_W	283_P	1.325	1.00
270_A	284_V	1.320	1.00
201_I	205_I	1.313	1.00
102_S	166_T	1.278	1.00
161_V	319_A	1.274	1.00
197_K	200_L	1.274	1.00
66_A	255_I	1.272	1.00
209_T	213_L	1.266	1.00
131_A	162_L	1.263	1.00
270_A	281_S	1.262	1.00
213_L	241_G	1.256	1.00
16_L	288_A	1.256	1.00
228_T	235_A	1.252	1.00
69_L	196_L	1.236	1.00
98_N	249_C	1.236	1.00
75_G	266_M	1.235	1.00
20_L	290_P	1.229	1.00
54_T	58_D	1.223	1.00
266_M	292_L	1.222	1.00
236_R	239_L	1.186	1.00
266_M	288_A	1.184	1.00
34_S	37_A	1.175	1.00
226_T	229_A	1.175	1.00
219_S	230_L	1.173	1.00
84_L	241_G	1.173	1.00
104_A	127_G	1.172	1.00
13_V	280_W	1.157	1.00
16_L	291_A	1.156	1.00
237_T	240_I	1.155	1.00
43_A	53_C	1.151	1.00
278_H	281_S	1.149	1.00
106_V	180_L	1.144	1.00
199_V	255_I	1.138	1.00
33_K	55_I	1.135	1.00
256_V	259_I	1.135	1.00
51_A	54_T	1.133	1.00
102_S	184_Q	1.120	1.00
72_G	290_P	1.111	1.00
67_G	294_L	1.107	1.00
133_L	137_F	1.106	1.00
125_F	247_V	1.105	1.00
79_A	282_L	1.104	1.00
301_R	307_E	1.104	1.00
235_A	238_Q	1.099	1.00
67_G	293_L	1.092	1.00
122_A	126_A	1.089	1.00
66_A	196_L	1.079	1.00
11_I	14_P	1.075	1.00
208_A	212_L	1.074	1.00
100_G	131_A	1.073	1.00
72_G	75_G	1.073	1.00
116_S	119_E	1.072	1.00
110_A	169_I	1.070	1.00
43_A	56_V	1.067	1.00
209_T	240_I	1.064	1.00
223_G	227_A	1.063	1.00
103_F	107_L	1.063	1.00
79_A	278_H	1.061	1.00
69_L	199_V	1.060	1.00
159_A	163_E	1.050	1.00
235_A	239_L	1.049	1.00
65_L	193_L	1.044	1.00
100_G	127_G	1.043	1.00
210_A	244_A	1.042	1.00
283_P	286_L	1.036	1.00
199_V	203_V	1.033	1.00
30_I	302_V	1.026	1.00
29_L	40_V	1.024	1.00
47_T	57_L	1.017	1.00
140_S	235_A	1.015	1.00
297_D	301_R	1.010	1.00
99_A	162_L	1.010	1.00
135_V	158_L	1.004	1.00
123_M	127_G	1.003	1.00
300_G	313_V	1.001	1.00
174_P	178_D	1.001	1.00
24_T	294_L	0.998	1.00
205_I	208_A	0.995	1.00
28_L	64_T	0.990	1.00
299_I	302_V	0.986	1.00
25_A	29_L	0.985	1.00
274_V	280_W	0.985	1.00
237_T	241_G	0.973	1.00
291_A	295_F	0.971	1.00
17_L	21_I	0.971	1.00
43_A	47_T	0.967	1.00
217_L	241_G	0.966	1.00
206_A	251_S	0.966	1.00
23_A	298_I	0.964	1.00
259_I	293_L	0.962	1.00
107_L	169_I	0.960	1.00
98_N	258_P	0.952	1.00
57_L	61_L	0.952	1.00
18_L	22_I	0.951	1.00
281_S	285_T	0.949	1.00
266_M	270_A	0.948	1.00
201_I	204_L	0.948	1.00
64_T	298_I	0.935	1.00
43_A	52_D	0.930	1.00
280_W	284_V	0.923	1.00
315_A	320_P	0.919	1.00
173_N	176_V	0.917	1.00
320_P	324_F	0.914	1.00
103_F	166_T	0.911	1.00
198_V	201_I	0.908	1.00
130_V	134_I	0.907	1.00
69_L	203_V	0.902	1.00
252_A	256_V	0.900	1.00
168_G	172_L	0.896	1.00
31_G	60_R	0.896	1.00
97_V	128_A	0.889	1.00
225_D	228_T	0.888	1.00
40_V	56_V	0.880	1.00
193_L	196_L	0.880	1.00
11_I	15_G	0.879	1.00
48_C	53_C	0.879	1.00
232_S	237_T	0.876	1.00
78_G	267_P	0.874	1.00
42_E	46_G	0.874	1.00
53_C	58_D	0.874	1.00
140_S	145_Q	0.869	1.00
277_D	280_W	0.867	1.00
105_I	120_Q	0.866	1.00
17_L	287_L	0.866	1.00
321_V	324_F	0.864	1.00
273_L	288_A	0.860	1.00
12_A	15_G	0.858	1.00
77_A	245_I	0.857	1.00
295_F	299_I	0.854	1.00
72_G	207_G	0.850	1.00
103_F	169_I	0.850	1.00
224_S	228_T	0.847	1.00
35_L	56_V	0.846	1.00
218_N	279_R	0.844	1.00
21_I	25_A	0.844	1.00
174_P	177_Y	0.842	1.00
42_E	45_S	0.840	1.00
25_A	37_A	0.834	1.00
180_L	184_Q	0.832	1.00
300_G	309_R	0.832	1.00
109_A	120_Q	0.828	1.00
12_A	16_L	0.828	1.00
64_T	294_L	0.827	1.00
73_A	77_A	0.823	1.00
271_R	281_S	0.815	1.00
278_H	283_P	0.813	1.00
239_L	243_L	0.812	1.00
45_S	48_C	0.807	1.00
234_V	238_Q	0.804	1.00
42_E	47_T	0.802	1.00
214_S	279_R	0.800	1.00
213_L	244_A	0.799	1.00
93_G	98_N	0.799	1.00
20_L	24_T	0.799	1.00
136_A	239_L	0.795	1.00
75_G	79_A	0.794	1.00
101_A	128_A	0.792	1.00
126_A	130_V	0.790	1.00
242_L	246_T	0.788	1.00
178_D	181_R	0.786	1.00
204_L	208_A	0.786	1.00
175_D	179_Q	0.785	1.00
209_T	212_L	0.783	1.00
224_S	234_V	0.783	1.00
140_S	146_L	0.778	1.00
194_H	197_K	0.777	1.00
29_L	34_S	0.770	1.00
270_A	274_V	0.769	1.00
227_A	234_V	0.768	1.00
61_L	193_L	0.768	1.00
119_E	122_A	0.765	1.00
210_A	241_G	0.765	1.00
63_R	301_R	0.764	1.00
195_T	255_I	0.760	1.00
108_G	120_Q	0.759	1.00
262_I	314_S	0.756	1.00
203_V	252_A	0.756	1.00
81_M	95_L	0.754	1.00
30_I	34_S	0.753	1.00
125_F	129_L	0.753	1.00
46_G	53_C	0.748	1.00
72_G	203_V	0.746	1.00
135_V	139_G	0.744	1.00
27_S	301_R	0.744	1.00
63_R	307_E	0.742	1.00
287_L	291_A	0.742	1.00
129_L	250_G	0.741	1.00
50_S	54_T	0.740	1.00
35_L	52_D	0.740	1.00
99_A	102_S	0.735	1.00
97_V	132_S	0.735	1.00
212_L	216_A	0.734	1.00
100_G	162_L	0.730	1.00
91_D	94_L	0.730	1.00
21_I	24_T	0.730	1.00
316_F	320_P	0.730	1.00
137_F	140_S	0.728	1.00
136_A	235_A	0.728	1.00
293_L	314_S	0.728	1.00
270_A	273_L	0.724	1.00
107_L	165_L	0.720	1.00
202_P	206_A	0.719	1.00
54_T	57_L	0.716	1.00
76_L	210_A	0.712	1.00
49_Q	53_C	0.710	1.00
199_V	251_S	0.710	1.00
33_K	37_A	0.710	1.00
74_L	262_I	0.709	1.00
211_L	214_S	0.706	1.00
132_S	242_L	0.704	1.00
22_I	25_A	0.702	1.00
107_L	112_F	0.701	1.00
324_F	328_R	0.699	1.00
304_V	308_L	0.698	1.00
216_A	232_S	0.697	1.00
33_K	36_P	0.696	1.00
128_A	246_T	0.696	1.00
120_Q	123_M	0.691	1.00
290_P	294_L	0.689	1.00
199_V	202_P	0.687	1.00
75_G	286_L	0.687	1.00
106_V	170_A	0.686	1.00
85_T	152_T	0.686	1.00
40_V	43_A	0.686	1.00
109_A	179_Q	0.685	1.00
65_L	69_L	0.684	1.00
76_L	282_L	0.682	1.00
207_G	211_L	0.682	1.00
200_L	204_L	0.681	1.00
77_A	249_C	0.681	1.00
138_T	154_A	0.679	1.00
259_I	310_V	0.677	1.00
228_T	234_V	0.677	1.00
269_M	288_A	0.675	1.00
20_L	294_L	0.674	1.00
251_S	254_A	0.671	1.00
218_N	283_P	0.671	1.00
220_L	234_V	0.671	1.00
28_L	61_L	0.668	1.00
66_A	199_V	0.666	1.00
54_T	59_A	0.665	1.00
272_W	325_L	0.660	1.00
131_A	135_V	0.659	1.00
251_S	255_I	0.659	1.00
28_L	56_V	0.659	1.00
142_G	150_R	0.655	1.00
102_S	258_P	0.654	1.00
267_P	285_T	0.654	1.00
181_R	184_Q	0.653	1.00
118_Q	122_A	0.651	1.00
293_L	310_V	0.650	1.00
142_G	145_Q	0.649	1.00
292_L	296_A	0.644	1.00
167_S	183_W	0.643	1.00
202_P	247_V	0.643	1.00
262_I	292_L	0.638	1.00
188_L	310_V	0.636	1.00
83_T	221_S	0.636	1.00
286_L	290_P	0.635	1.00
269_M	292_L	0.635	1.00
170_A	181_R	0.635	1.00
269_M	272_W	0.633	1.00
16_L	20_L	0.633	1.00
35_L	43_A	0.632	1.00
265_M	322_L	0.631	1.00
163_E	184_Q	0.631	1.00
37_A	41_L	0.626	1.00
292_L	317_I	0.626	1.00
206_A	210_A	0.624	1.00
61_L	65_L	0.624	1.00
176_V	179_Q	0.622	1.00
193_L	197_K	0.622	1.00
296_A	313_V	0.622	1.00
104_A	108_G	0.620	1.00
70_A	188_L	0.620	1.00
147_S	150_R	0.618	1.00
91_D	263_G	0.616	1.00
12_A	273_L	0.615	1.00
129_L	246_T	0.612	1.00
109_A	180_L	0.612	1.00
297_D	307_E	0.611	1.00
167_S	171_L	0.610	1.00
80_L	244_A	0.610	1.00
295_F	298_I	0.609	1.00
98_N	101_A	0.609	1.00
264_L	325_L	0.607	1.00
15_G	19_L	0.604	1.00
149_V	152_T	0.597	1.00
27_S	294_L	0.597	1.00
56_V	61_L	0.597	1.00
99_A	159_A	0.597	1.00
302_V	305_P	0.596	1.00
22_I	26_L	0.596	1.00
37_A	40_V	0.594	1.00
283_P	287_L	0.593	1.00
154_A	157_A	0.592	1.00
163_E	167_S	0.591	1.00
32_A	305_P	0.589	1.00
249_C	253_T	0.589	1.00
132_S	136_A	0.587	1.00
108_G	119_E	0.586	1.00
72_G	76_L	0.585	1.00
137_F	141_Q	0.585	1.00
134_I	137_F	0.584	1.00
216_A	219_S	0.583	1.00
139_G	154_A	0.582	1.00
275_G	283_P	0.578	0.99
188_L	256_V	0.577	0.99
85_T	88_P	0.575	0.99
30_I	298_I	0.574	0.99
265_M	321_V	0.574	0.99
300_G	307_E	0.574	0.99
327_R	330_T	0.574	0.99
67_G	310_V	0.571	0.99
38_S	41_L	0.570	0.99
212_L	215_R	0.570	0.99
130_V	133_L	0.569	0.99
36_P	52_D	0.569	0.99
269_M	321_V	0.569	0.99
203_V	207_G	0.569	0.99
25_A	41_L	0.568	0.99
43_A	48_C	0.567	0.99
24_T	28_L	0.566	0.99
126_A	129_L	0.565	0.99
12_A	274_V	0.565	0.99
127_G	131_A	0.565	0.99
241_G	245_I	0.564	0.99
240_I	244_A	0.562	0.99
13_V	17_L	0.561	0.99
81_M	90_A	0.560	0.99
265_M	269_M	0.560	0.99
66_A	70_A	0.559	0.99
250_G	254_A	0.555	0.99
39_V	46_G	0.553	0.99
194_H	198_V	0.552	0.99
15_G	18_L	0.552	0.99
108_G	112_F	0.552	0.99
29_L	41_L	0.552	0.99
42_E	48_C	0.551	0.99
240_I	243_L	0.551	0.99
233_R	240_I	0.550	0.99
99_A	163_E	0.550	0.99
81_M	97_V	0.545	0.99
298_I	302_V	0.543	0.99
220_L	237_T	0.543	0.99
218_N	221_S	0.540	0.99
279_R	283_P	0.540	0.99
40_V	44_F	0.536	0.99
205_I	209_T	0.533	0.99
136_A	140_S	0.533	0.99
13_V	287_L	0.533	0.99
23_A	26_L	0.533	0.99
246_T	250_G	0.531	0.99
215_R	218_N	0.528	0.99
198_V	202_P	0.528	0.99
294_L	298_I	0.528	0.99
105_I	123_M	0.526	0.99
26_L	298_I	0.525	0.99
97_V	135_V	0.525	0.99
131_A	158_L	0.524	0.99
86_R	224_S	0.522	0.99
139_G	151_L	0.520	0.99
170_A	184_Q	0.520	0.99
75_G	289_T	0.519	0.99
117_A	121_L	0.519	0.99
207_G	286_L	0.518	0.99
100_G	158_L	0.518	0.99
196_L	200_L	0.516	0.99
146_L	150_R	0.516	0.99
40_V	45_S	0.514	0.99
270_A	285_T	0.514	0.99
177_Y	180_L	0.513	0.99
260_A	265_M	0.513	0.99
288_A	291_A	0.512	0.99
80_L	245_I	0.512	0.99
210_A	282_L	0.511	0.99
97_V	187_S	0.510	0.99
66_A	256_V	0.510	0.99
268_H	271_R	0.510	0.99
14_P	18_L	0.510	0.99
196_L	199_V	0.509	0.99
17_L	20_L	0.509	0.99
154_A	158_L	0.509	0.99
233_R	239_L	0.508	0.99
79_A	270_A	0.506	0.99
44_F	56_V	0.505	0.99
300_G	303_I	0.504	0.99
170_A	180_L	0.503	0.99
101_A	124_A	0.502	0.99
245_I	250_G	0.502	0.99
217_L	278_H	0.501	0.99
170_A	177_Y	0.501	0.99
164_G	265_M	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9192	100	0.184	Contact Map
4g1uA	2	0.8832	100	0.192	Contact Map
2qi9A	2	0.9431	100	0.201	Contact Map
2xq2A	2	0.6796	27.4	0.96	Contact Map
3rlbA	1	0.506	20.3	0.963	Contact Map
1pw4A	1	0.8713	16	0.964	Contact Map
2l9uA	2	0.0898	12.2	0.966	Contact Map
2m20A	2	0.0778	11.6	0.966	Contact Map
4z7fA	2	0.485	9.3	0.968	Contact Map
3o7qA	1	0.8473	8.4	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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