GREMLIN Database
FEPD - Ferric enterobactin transport system permease protein FepD
UniProt: P23876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10296
Length: 334 (318)
Sequences: 13884 (9922)
Seq/√Len: 556.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_N277_D4.4421.00
72_G286_L3.7551.00
108_G123_M3.6301.00
23_A295_F3.5461.00
80_L210_A3.4781.00
24_T64_T3.3371.00
233_R236_R3.2391.00
73_A203_V3.1111.00
80_L241_G3.0551.00
68_L290_P2.9781.00
67_G188_L2.8881.00
270_A288_A2.7811.00
39_V52_D2.7411.00
66_A191_R2.5761.00
76_L286_L2.5301.00
73_A248_L2.5211.00
73_A252_A2.5071.00
24_T68_L2.4621.00
39_V42_E2.4461.00
103_F165_L2.3981.00
224_S238_Q2.3711.00
20_L291_A2.3241.00
19_L291_A2.2671.00
70_A252_A2.2581.00
76_L207_G2.1971.00
79_A285_T2.1881.00
274_V284_V2.1441.00
29_L37_A2.1151.00
68_L294_L2.0521.00
202_P251_S2.0451.00
70_A256_V2.0401.00
49_Q52_D2.0391.00
20_L68_L2.0311.00
103_F162_L2.0281.00
216_A237_T2.0061.00
36_P39_V1.9941.00
69_L200_L1.9281.00
63_R297_D1.9261.00
107_L111_L1.9081.00
27_S64_T1.9051.00
218_N278_H1.8611.00
81_M245_I1.8491.00
83_T278_H1.8471.00
213_L216_A1.8361.00
219_S232_S1.8221.00
106_V166_T1.8081.00
38_S42_E1.8081.00
23_A291_A1.7981.00
13_V284_V1.7741.00
209_T244_A1.7651.00
191_R195_T1.6951.00
53_C57_L1.6941.00
206_A248_L1.6921.00
50_S53_C1.6391.00
213_L240_I1.6371.00
236_R240_I1.6101.00
47_T53_C1.5951.00
299_I303_I1.5791.00
79_A281_S1.5741.00
65_L196_L1.5451.00
262_I293_L1.5411.00
105_I124_A1.5251.00
26_L29_L1.5201.00
132_S246_T1.5151.00
192_N195_T1.5151.00
20_L287_L1.5071.00
206_A247_V1.5031.00
16_L287_L1.4961.00
197_K201_I1.4961.00
43_A57_L1.4931.00
213_L237_T1.4931.00
128_A250_G1.4931.00
300_G310_V1.4801.00
104_A123_M1.4651.00
26_L30_I1.4371.00
23_A294_L1.4331.00
188_L293_L1.4111.00
12_A284_V1.4071.00
206_A244_A1.3691.00
41_L45_S1.3671.00
16_L284_V1.3561.00
77_A248_L1.3541.00
299_I313_V1.3521.00
27_S298_I1.3421.00
280_W283_P1.3251.00
270_A284_V1.3201.00
201_I205_I1.3131.00
102_S166_T1.2781.00
161_V319_A1.2741.00
197_K200_L1.2741.00
66_A255_I1.2721.00
209_T213_L1.2661.00
131_A162_L1.2631.00
270_A281_S1.2621.00
213_L241_G1.2561.00
16_L288_A1.2561.00
228_T235_A1.2521.00
69_L196_L1.2361.00
98_N249_C1.2361.00
75_G266_M1.2351.00
20_L290_P1.2291.00
54_T58_D1.2231.00
266_M292_L1.2221.00
236_R239_L1.1861.00
266_M288_A1.1841.00
34_S37_A1.1751.00
226_T229_A1.1751.00
219_S230_L1.1731.00
84_L241_G1.1731.00
104_A127_G1.1721.00
13_V280_W1.1571.00
16_L291_A1.1561.00
237_T240_I1.1551.00
43_A53_C1.1511.00
278_H281_S1.1491.00
106_V180_L1.1441.00
199_V255_I1.1381.00
33_K55_I1.1351.00
256_V259_I1.1351.00
51_A54_T1.1331.00
102_S184_Q1.1201.00
72_G290_P1.1111.00
67_G294_L1.1071.00
133_L137_F1.1061.00
125_F247_V1.1051.00
79_A282_L1.1041.00
301_R307_E1.1041.00
235_A238_Q1.0991.00
67_G293_L1.0921.00
122_A126_A1.0891.00
66_A196_L1.0791.00
11_I14_P1.0751.00
208_A212_L1.0741.00
100_G131_A1.0731.00
72_G75_G1.0731.00
116_S119_E1.0721.00
110_A169_I1.0701.00
43_A56_V1.0671.00
209_T240_I1.0641.00
223_G227_A1.0631.00
103_F107_L1.0631.00
79_A278_H1.0611.00
69_L199_V1.0601.00
159_A163_E1.0501.00
235_A239_L1.0491.00
65_L193_L1.0441.00
100_G127_G1.0431.00
210_A244_A1.0421.00
283_P286_L1.0361.00
199_V203_V1.0331.00
30_I302_V1.0261.00
29_L40_V1.0241.00
47_T57_L1.0171.00
140_S235_A1.0151.00
297_D301_R1.0101.00
99_A162_L1.0101.00
135_V158_L1.0041.00
123_M127_G1.0031.00
300_G313_V1.0011.00
174_P178_D1.0011.00
24_T294_L0.9981.00
205_I208_A0.9951.00
28_L64_T0.9901.00
299_I302_V0.9861.00
25_A29_L0.9851.00
274_V280_W0.9851.00
237_T241_G0.9731.00
291_A295_F0.9711.00
17_L21_I0.9711.00
43_A47_T0.9671.00
217_L241_G0.9661.00
206_A251_S0.9661.00
23_A298_I0.9641.00
259_I293_L0.9621.00
107_L169_I0.9601.00
98_N258_P0.9521.00
57_L61_L0.9521.00
18_L22_I0.9511.00
281_S285_T0.9491.00
266_M270_A0.9481.00
201_I204_L0.9481.00
64_T298_I0.9351.00
43_A52_D0.9301.00
280_W284_V0.9231.00
315_A320_P0.9191.00
173_N176_V0.9171.00
320_P324_F0.9141.00
103_F166_T0.9111.00
198_V201_I0.9081.00
130_V134_I0.9071.00
69_L203_V0.9021.00
252_A256_V0.9001.00
168_G172_L0.8961.00
31_G60_R0.8961.00
97_V128_A0.8891.00
225_D228_T0.8881.00
40_V56_V0.8801.00
193_L196_L0.8801.00
11_I15_G0.8791.00
48_C53_C0.8791.00
232_S237_T0.8761.00
78_G267_P0.8741.00
42_E46_G0.8741.00
53_C58_D0.8741.00
140_S145_Q0.8691.00
277_D280_W0.8671.00
105_I120_Q0.8661.00
17_L287_L0.8661.00
321_V324_F0.8641.00
273_L288_A0.8601.00
12_A15_G0.8581.00
77_A245_I0.8571.00
295_F299_I0.8541.00
72_G207_G0.8501.00
103_F169_I0.8501.00
224_S228_T0.8471.00
35_L56_V0.8461.00
218_N279_R0.8441.00
21_I25_A0.8441.00
174_P177_Y0.8421.00
42_E45_S0.8401.00
25_A37_A0.8341.00
180_L184_Q0.8321.00
300_G309_R0.8321.00
109_A120_Q0.8281.00
12_A16_L0.8281.00
64_T294_L0.8271.00
73_A77_A0.8231.00
271_R281_S0.8151.00
278_H283_P0.8131.00
239_L243_L0.8121.00
45_S48_C0.8071.00
234_V238_Q0.8041.00
42_E47_T0.8021.00
214_S279_R0.8001.00
213_L244_A0.7991.00
93_G98_N0.7991.00
20_L24_T0.7991.00
136_A239_L0.7951.00
75_G79_A0.7941.00
101_A128_A0.7921.00
126_A130_V0.7901.00
242_L246_T0.7881.00
178_D181_R0.7861.00
204_L208_A0.7861.00
175_D179_Q0.7851.00
209_T212_L0.7831.00
224_S234_V0.7831.00
140_S146_L0.7781.00
194_H197_K0.7771.00
29_L34_S0.7701.00
270_A274_V0.7691.00
227_A234_V0.7681.00
61_L193_L0.7681.00
119_E122_A0.7651.00
210_A241_G0.7651.00
63_R301_R0.7641.00
195_T255_I0.7601.00
108_G120_Q0.7591.00
262_I314_S0.7561.00
203_V252_A0.7561.00
81_M95_L0.7541.00
30_I34_S0.7531.00
125_F129_L0.7531.00
46_G53_C0.7481.00
72_G203_V0.7461.00
135_V139_G0.7441.00
27_S301_R0.7441.00
63_R307_E0.7421.00
287_L291_A0.7421.00
129_L250_G0.7411.00
50_S54_T0.7401.00
35_L52_D0.7401.00
99_A102_S0.7351.00
97_V132_S0.7351.00
212_L216_A0.7341.00
100_G162_L0.7301.00
91_D94_L0.7301.00
21_I24_T0.7301.00
316_F320_P0.7301.00
137_F140_S0.7281.00
136_A235_A0.7281.00
293_L314_S0.7281.00
270_A273_L0.7241.00
107_L165_L0.7201.00
202_P206_A0.7191.00
54_T57_L0.7161.00
76_L210_A0.7121.00
49_Q53_C0.7101.00
199_V251_S0.7101.00
33_K37_A0.7101.00
74_L262_I0.7091.00
211_L214_S0.7061.00
132_S242_L0.7041.00
22_I25_A0.7021.00
107_L112_F0.7011.00
324_F328_R0.6991.00
304_V308_L0.6981.00
216_A232_S0.6971.00
33_K36_P0.6961.00
128_A246_T0.6961.00
120_Q123_M0.6911.00
290_P294_L0.6891.00
199_V202_P0.6871.00
75_G286_L0.6871.00
106_V170_A0.6861.00
85_T152_T0.6861.00
40_V43_A0.6861.00
109_A179_Q0.6851.00
65_L69_L0.6841.00
76_L282_L0.6821.00
207_G211_L0.6821.00
200_L204_L0.6811.00
77_A249_C0.6811.00
138_T154_A0.6791.00
259_I310_V0.6771.00
228_T234_V0.6771.00
269_M288_A0.6751.00
20_L294_L0.6741.00
251_S254_A0.6711.00
218_N283_P0.6711.00
220_L234_V0.6711.00
28_L61_L0.6681.00
66_A199_V0.6661.00
54_T59_A0.6651.00
272_W325_L0.6601.00
131_A135_V0.6591.00
251_S255_I0.6591.00
28_L56_V0.6591.00
142_G150_R0.6551.00
102_S258_P0.6541.00
267_P285_T0.6541.00
181_R184_Q0.6531.00
118_Q122_A0.6511.00
293_L310_V0.6501.00
142_G145_Q0.6491.00
292_L296_A0.6441.00
167_S183_W0.6431.00
202_P247_V0.6431.00
262_I292_L0.6381.00
188_L310_V0.6361.00
83_T221_S0.6361.00
286_L290_P0.6351.00
269_M292_L0.6351.00
170_A181_R0.6351.00
269_M272_W0.6331.00
16_L20_L0.6331.00
35_L43_A0.6321.00
265_M322_L0.6311.00
163_E184_Q0.6311.00
37_A41_L0.6261.00
292_L317_I0.6261.00
206_A210_A0.6241.00
61_L65_L0.6241.00
176_V179_Q0.6221.00
193_L197_K0.6221.00
296_A313_V0.6221.00
104_A108_G0.6201.00
70_A188_L0.6201.00
147_S150_R0.6181.00
91_D263_G0.6161.00
12_A273_L0.6151.00
129_L246_T0.6121.00
109_A180_L0.6121.00
297_D307_E0.6111.00
167_S171_L0.6101.00
80_L244_A0.6101.00
295_F298_I0.6091.00
98_N101_A0.6091.00
264_L325_L0.6071.00
15_G19_L0.6041.00
149_V152_T0.5971.00
27_S294_L0.5971.00
56_V61_L0.5971.00
99_A159_A0.5971.00
302_V305_P0.5961.00
22_I26_L0.5961.00
37_A40_V0.5941.00
283_P287_L0.5931.00
154_A157_A0.5921.00
163_E167_S0.5911.00
32_A305_P0.5891.00
249_C253_T0.5891.00
132_S136_A0.5871.00
108_G119_E0.5861.00
72_G76_L0.5851.00
137_F141_Q0.5851.00
134_I137_F0.5841.00
216_A219_S0.5831.00
139_G154_A0.5821.00
275_G283_P0.5780.99
188_L256_V0.5770.99
85_T88_P0.5750.99
30_I298_I0.5740.99
265_M321_V0.5740.99
300_G307_E0.5740.99
327_R330_T0.5740.99
67_G310_V0.5710.99
38_S41_L0.5700.99
212_L215_R0.5700.99
130_V133_L0.5690.99
36_P52_D0.5690.99
269_M321_V0.5690.99
203_V207_G0.5690.99
25_A41_L0.5680.99
43_A48_C0.5670.99
24_T28_L0.5660.99
126_A129_L0.5650.99
12_A274_V0.5650.99
127_G131_A0.5650.99
241_G245_I0.5640.99
240_I244_A0.5620.99
13_V17_L0.5610.99
81_M90_A0.5600.99
265_M269_M0.5600.99
66_A70_A0.5590.99
250_G254_A0.5550.99
39_V46_G0.5530.99
194_H198_V0.5520.99
15_G18_L0.5520.99
108_G112_F0.5520.99
29_L41_L0.5520.99
42_E48_C0.5510.99
240_I243_L0.5510.99
233_R240_I0.5500.99
99_A163_E0.5500.99
81_M97_V0.5450.99
298_I302_V0.5430.99
220_L237_T0.5430.99
218_N221_S0.5400.99
279_R283_P0.5400.99
40_V44_F0.5360.99
205_I209_T0.5330.99
136_A140_S0.5330.99
13_V287_L0.5330.99
23_A26_L0.5330.99
246_T250_G0.5310.99
215_R218_N0.5280.99
198_V202_P0.5280.99
294_L298_I0.5280.99
105_I123_M0.5260.99
26_L298_I0.5250.99
97_V135_V0.5250.99
131_A158_L0.5240.99
86_R224_S0.5220.99
139_G151_L0.5200.99
170_A184_Q0.5200.99
75_G289_T0.5190.99
117_A121_L0.5190.99
207_G286_L0.5180.99
100_G158_L0.5180.99
196_L200_L0.5160.99
146_L150_R0.5160.99
40_V45_S0.5140.99
270_A285_T0.5140.99
177_Y180_L0.5130.99
260_A265_M0.5130.99
288_A291_A0.5120.99
80_L245_I0.5120.99
210_A282_L0.5110.99
97_V187_S0.5100.99
66_A256_V0.5100.99
268_H271_R0.5100.99
14_P18_L0.5100.99
196_L199_V0.5090.99
17_L20_L0.5090.99
154_A158_L0.5090.99
233_R239_L0.5080.99
79_A270_A0.5060.99
44_F56_V0.5050.99
300_G303_I0.5040.99
170_A180_L0.5030.99
101_A124_A0.5020.99
245_I250_G0.5020.99
217_L278_H0.5010.99
170_A177_Y0.5010.99
164_G265_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9192 100 0.184 Contact Map
4g1uA 2 0.8832 100 0.192 Contact Map
2qi9A 2 0.9431 100 0.201 Contact Map
2xq2A 2 0.6796 27.4 0.96 Contact Map
3rlbA 1 0.506 20.3 0.963 Contact Map
1pw4A 1 0.8713 16 0.964 Contact Map
2l9uA 2 0.0898 12.2 0.966 Contact Map
2m20A 2 0.0778 11.6 0.966 Contact Map
4z7fA 2 0.485 9.3 0.968 Contact Map
3o7qA 1 0.8473 8.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.