GREMLIN Database
HIPA - Serine/threonine-protein kinase HipA
UniProt: P23874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10443
Length: 440 (380)
Sequences: 2456 (1927)
Seq/√Len: 98.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_D234_E5.5601.00
293_Y387_Q4.4741.00
14_G26_F4.3771.00
207_L220_A4.0511.00
297_K391_I3.6831.00
297_K394_D3.6721.00
208_L211_K3.6711.00
206_C305_I3.1931.00
301_F305_I3.0231.00
121_T124_R2.9941.00
252_Q316_S2.9721.00
371_P393_S2.9721.00
204_Y220_A2.9681.00
318_F328_T2.9391.00
252_Q331_Y2.8811.00
211_K219_D2.8701.00
291_D326_R2.8271.00
320_Q326_R2.7621.00
215_L330_F2.7521.00
216_N294_D2.7351.00
285_S291_D2.6761.00
212_E405_N2.6601.00
255_M278_I2.5431.00
30_P34_A2.4781.00
201_D229_R2.4631.00
32_W39_R2.4601.00
204_Y208_L2.4201.00
218_P233_V2.4031.00
64_L103_L2.3721.00
12_R29_A2.3651.00
252_Q318_F2.3611.00
16_L61_F2.3501.00
240_W244_R2.3381.00
378_A388_M2.3291.00
296_M388_M2.3071.00
5_V107_D2.2961.00
316_S331_Y2.1641.00
210_A333_I2.1371.00
298_F330_F2.1231.00
254_D331_Y2.1221.00
209_L402_A2.1201.00
330_F333_I2.1171.00
5_V12_R2.1111.00
288_A291_D2.0831.00
357_N373_H2.0761.00
7_W104_I2.0741.00
13_V32_W2.0571.00
213_L398_M2.0461.00
283_M292_R2.0371.00
210_A301_F2.0341.00
223_I232_A2.0011.00
401_A404_D2.0011.00
11_Q35_S1.9611.00
48_Q52_I1.9431.00
319_I323_G1.9381.00
239_R248_L1.8341.00
385_E389_H1.8331.00
85_Q88_D1.8131.00
256_C312_A1.7961.00
126_E227_N1.7921.00
38_A47_L1.7881.00
126_E226_G1.7871.00
375_L389_H1.7731.00
207_L231_L1.7601.00
303_W374_F1.7191.00
207_L217_V1.6901.00
391_I394_D1.6811.00
72_R76_V1.6721.00
294_D298_F1.6461.00
282_L295_F1.6391.00
40_P47_L1.6211.00
180_I232_A1.6211.00
208_L409_S1.6201.00
40_P46_P1.5981.00
200_V222_I1.5971.00
300_V391_I1.5501.00
130_T228_V1.5231.00
102_T249_R1.5111.00
207_L218_P1.5091.00
216_N326_R1.5051.00
33_L47_L1.4971.00
294_D297_K1.4901.00
43_L253_E1.4721.00
6_T26_F1.4681.00
5_V106_E1.4551.00
162_R221_E1.4481.00
73_D77_K1.4331.00
279_M292_R1.4261.00
224_K227_N1.4211.00
4_L91_S1.4171.00
371_P389_H1.4111.00
375_L378_A1.4091.00
241_N248_L1.3971.00
213_L399_I1.3940.99
118_E124_R1.3750.99
275_I299_Q1.3700.99
298_F315_F1.3700.99
5_V104_I1.3580.99
204_Y222_I1.3570.99
279_M295_F1.3510.99
6_T103_L1.3510.99
67_D154_A1.3390.99
12_R15_E1.3310.99
224_K229_R1.3300.99
304_L395_F1.3300.99
416_E420_T1.3250.99
218_P231_L1.3240.99
7_W12_R1.3230.99
310_G315_F1.3200.99
253_E257_Q1.3160.99
202_N335_S1.3080.99
370_Y373_H1.3080.99
213_L395_F1.2980.99
18_K85_Q1.2970.99
126_E130_T1.2910.99
100_A251_P1.2830.99
278_I295_F1.2820.99
15_E29_A1.2810.99
287_E290_K1.2800.99
282_L317_V1.2680.99
405_N409_S1.2660.99
8_M13_V1.2640.99
293_Y297_K1.2590.99
220_A233_V1.2550.99
250_L318_F1.2500.99
389_H393_S1.2490.99
379_K385_E1.2280.99
202_N206_C1.2160.99
365_A368_K1.2080.99
209_L305_I1.2080.99
127_E131_A1.2060.99
17_T25_T1.1920.98
377_T381_L1.1820.98
151_V159_A1.1790.98
303_W356_L1.1720.98
208_L220_A1.1640.98
178_H234_E1.1640.98
239_R250_L1.1550.98
45_L52_I1.1540.98
151_V179_I1.1510.98
276_A380_V1.1500.98
357_N376_A1.1410.98
89_L92_E1.1380.98
176_T234_E1.1200.98
302_Q310_G1.1130.97
304_L399_I1.1000.97
401_A405_N1.0980.97
291_D294_D1.0930.97
387_Q391_I1.0890.97
375_L388_M1.0890.97
255_M317_V1.0870.97
308_T336_A1.0830.97
208_L212_E1.0830.97
258_T317_V1.0770.97
10_N102_T1.0740.97
160_L180_I1.0740.97
300_V392_L1.0680.97
293_Y391_I1.0660.97
180_I230_A1.0580.97
212_E409_S1.0360.96
127_E130_T1.0340.96
213_L301_F1.0330.96
117_W168_C1.0300.96
18_K24_H1.0290.96
205_Y405_N1.0280.96
72_R86_P1.0220.96
196_L339_V1.0210.96
311_H332_D1.0160.96
398_M405_N1.0150.96
291_D327_L1.0120.96
418_V422_V1.0120.96
215_L297_K1.0070.95
297_K395_F1.0050.95
217_V220_A1.0030.95
296_M392_L0.9990.95
7_W110_V0.9980.95
296_M300_V0.9820.95
60_F253_E0.9820.95
387_Q390_E0.9790.95
152_A254_D0.9690.94
304_L396_A0.9690.94
279_M381_L0.9680.94
255_M281_F0.9650.94
352_L369_I0.9640.94
48_Q51_N0.9620.94
305_I333_I0.9610.94
412_T416_E0.9600.94
14_G61_F0.9600.94
335_S338_P0.9560.94
178_H232_A0.9530.94
14_G29_A0.9510.94
390_E394_D0.9510.94
46_P52_I0.9500.94
19_L25_T0.9420.94
219_D412_T0.9420.94
157_K311_H0.9410.94
285_S288_A0.9380.93
130_T226_G0.9340.93
43_L317_V0.9320.93
27_K50_G0.9310.93
236_F252_Q0.9300.93
62_D263_S0.9270.93
371_P375_L0.9250.93
181_K203_E0.9200.93
301_F333_I0.9190.93
259_F281_F0.9170.93
126_E129_L0.9140.92
63_N254_D0.9110.92
41_L101_V0.9100.92
212_E401_A0.9090.92
254_D316_S0.9050.92
39_R47_L0.9050.92
17_T27_K0.9040.92
393_S396_A0.9030.92
28_Y47_L0.9000.92
296_M378_A0.8980.92
225_A230_A0.8950.92
411_P414_F0.8870.91
63_N152_A0.8850.91
215_L301_F0.8810.91
204_Y231_L0.8770.91
403_L419_V0.8720.91
308_T334_I0.8700.91
279_M377_T0.8690.90
63_N257_Q0.8630.90
386_V412_T0.8540.90
282_L292_R0.8510.90
336_A350_L0.8490.89
64_L257_Q0.8490.89
26_F61_F0.8490.89
181_K314_N0.8480.89
225_A232_A0.8450.89
403_L416_E0.8420.89
210_A217_V0.8410.89
394_D398_M0.8390.89
308_T366_I0.8380.89
63_N310_G0.8370.89
203_E314_N0.8370.89
163_I166_D0.8340.89
183_P198_Q0.8320.88
15_E27_K0.8300.88
207_L233_V0.8290.88
8_M39_R0.8230.88
289_L387_Q0.8230.88
16_L90_L0.8210.88
302_Q307_A0.8190.88
258_T281_F0.8180.88
73_D76_V0.8160.88
8_M100_A0.8160.88
402_A406_V0.8150.87
170_P174_T0.8150.87
215_L298_F0.8090.87
117_W174_T0.8070.87
201_D222_I0.8060.87
181_K311_H0.8060.87
299_Q381_L0.8040.87
59_N262_P0.8040.87
157_K332_D0.8030.87
169_I174_T0.8010.87
241_N244_R0.7990.86
128_V180_I0.7980.86
405_N408_T0.7950.86
217_V233_V0.7950.86
5_V105_P0.7910.86
22_G86_P0.7900.86
200_V231_L0.7830.85
203_E311_H0.7820.85
65_L93_I0.7810.85
206_C333_I0.7810.85
7_W10_N0.7800.85
395_F399_I0.7790.85
255_M295_F0.7790.85
289_L384_P0.7780.85
71_V156_E0.7770.85
273_P312_A0.7760.85
155_Q310_G0.7760.85
8_M32_W0.7760.85
314_N332_D0.7750.85
159_A179_I0.7670.84
204_Y207_L0.7660.84
239_R244_R0.7650.84
279_M288_A0.7640.84
168_C171_K0.7610.84
28_Y40_P0.7590.83
199_S334_I0.7570.83
252_Q328_T0.7510.83
287_E326_R0.7510.83
256_C263_S0.7510.83
371_P374_F0.7500.83
119_K166_D0.7450.82
310_G325_Y0.7440.82
254_D313_K0.7440.82
42_S45_L0.7440.82
184_I199_S0.7420.82
42_S253_E0.7420.82
60_F257_Q0.7420.82
44_S260_G0.7410.82
238_R257_Q0.7390.82
217_V330_F0.7380.82
41_L404_D0.7360.82
157_K203_E0.7330.81
391_I395_F0.7310.81
157_K181_K0.7310.81
130_T204_Y0.7290.81
398_M402_A0.7280.81
375_L392_L0.7270.81
27_K51_N0.7260.81
60_F103_L0.7260.81
209_L405_N0.7260.81
43_L325_Y0.7230.80
123_A127_E0.7230.80
412_T420_T0.7230.80
311_H314_N0.7220.80
400_P403_L0.7220.80
383_F388_M0.7210.80
123_A126_E0.7210.80
49_R393_S0.7180.80
157_K236_F0.7170.80
408_T412_T0.7140.80
263_S313_K0.7130.79
253_E319_I0.7120.79
299_Q377_T0.7120.79
206_C335_S0.7120.79
315_F330_F0.7120.79
142_R331_Y0.7110.79
96_D257_Q0.7090.79
71_V310_G0.7080.79
251_P319_I0.7080.79
104_I110_V0.7070.79
309_D332_D0.7050.79
240_W248_L0.7030.79
134_A185_G0.7020.78
11_Q29_A0.7020.78
213_L402_A0.7010.78
201_D205_Y0.7000.78
290_K326_R0.6990.78
26_F45_L0.6940.78
57_V62_D0.6930.78
29_A34_A0.6930.78
202_N339_V0.6920.77
154_A254_D0.6890.77
167_W170_P0.6890.77
231_L305_I0.6880.77
207_L336_A0.6870.77
60_F101_V0.6850.77
404_D408_T0.6850.77
305_I399_I0.6840.77
148_R170_P0.6830.76
319_I325_Y0.6830.76
280_A283_M0.6830.76
150_S238_R0.6800.76
35_S38_A0.6790.76
159_A176_T0.6760.76
240_W322_G0.6760.76
371_P392_L0.6760.76
212_E386_V0.6710.75
65_L313_K0.6710.75
67_D313_K0.6710.75
181_K332_D0.6700.75
63_N298_F0.6700.75
279_M318_F0.6690.75
96_D238_R0.6680.75
157_K314_N0.6680.75
196_L308_T0.6670.75
254_D257_Q0.6670.75
16_L24_H0.6640.74
75_I93_I0.6620.74
415_P419_V0.6600.74
280_A284_G0.6600.74
67_D254_D0.6590.74
396_A400_P0.6570.74
67_D155_Q0.6550.73
40_P43_L0.6520.73
383_F387_Q0.6500.73
104_I107_D0.6490.73
203_E332_D0.6450.72
236_F311_H0.6430.72
129_L133_K0.6420.72
160_L167_W0.6420.72
218_P330_F0.6420.72
282_L291_D0.6390.72
30_P49_R0.6390.72
275_I310_G0.6370.71
158_T182_L0.6320.71
227_N395_F0.6310.71
39_R253_E0.6300.71
54_S57_V0.6290.70
253_E317_V0.6290.70
210_A305_I0.6270.70
45_L60_F0.6260.70
77_K376_A0.6260.70
67_D152_A0.6230.70
10_N390_E0.6220.70
212_E402_A0.6210.69
275_I279_M0.6190.69
211_K217_V0.6190.69
82_K281_F0.6180.69
4_L9_N0.6160.69
68_S264_S0.6150.69
40_P52_I0.6140.69
28_Y46_P0.6140.69
210_A302_Q0.6100.68
175_P236_F0.6100.68
28_Y62_D0.6090.68
209_L301_F0.6080.68
42_S60_F0.6080.68
149_I182_L0.6070.68
164_G167_W0.6060.68
275_I377_T0.6050.67
211_K220_A0.6050.67
72_R89_L0.6030.67
407_K415_P0.6030.67
375_L385_E0.6030.67
4_L8_M0.6000.67
202_N414_F0.6000.67
149_I184_I0.6000.67
169_I173_I0.5990.67
403_L407_K0.5990.67
14_G17_T0.5990.67
289_L390_E0.5990.67
402_A409_S0.5980.67
296_M377_T0.5980.67
24_H56_A0.5960.66
308_T369_I0.5930.66
133_K184_I0.5910.66
162_R165_N0.5900.66
317_V325_Y0.5900.66
98_V236_F0.5870.65
221_E232_A0.5860.65
168_C173_I0.5850.65
69_P73_D0.5850.65
61_F257_Q0.5850.65
300_V374_F0.5840.65
250_L320_Q0.5830.65
389_H392_L0.5820.65
165_N234_E0.5800.64
36_R47_L0.5800.64
125_L158_T0.5790.64
205_Y409_S0.5790.64
294_D327_L0.5770.64
277_R334_I0.5760.64
41_L60_F0.5740.63
274_G354_M0.5730.63
319_I328_T0.5720.63
401_A420_T0.5720.63
262_P265_V0.5700.63
308_T350_L0.5690.63
71_V152_A0.5690.63
69_P310_G0.5680.63
16_L58_F0.5680.63
417_N420_T0.5650.62
225_A228_V0.5650.62
128_V131_A0.5650.62
29_A327_L0.5650.62
168_C174_T0.5650.62
43_L295_F0.5640.62
71_V302_Q0.5630.62
397_R412_T0.5630.62
290_K293_Y0.5630.62
168_C175_P0.5620.62
73_D83_S0.5610.62
154_A313_K0.5590.61
116_A398_M0.5590.61
57_V86_P0.5590.61
276_A280_A0.5590.61
296_M383_F0.5580.61
79_Y83_S0.5570.61
254_D310_G0.5570.61
82_K85_Q0.5570.61
372_R376_A0.5570.61
76_V79_Y0.5570.61
11_Q39_R0.5570.61
42_S46_P0.5560.61
91_S418_V0.5550.61
122_E129_L0.5540.61
119_K250_L0.5520.60
4_L87_F0.5520.60
275_I295_F0.5500.60
160_L176_T0.5500.60
117_W121_T0.5500.60
371_P396_A0.5500.60
116_A280_A0.5500.60
306_G421_A0.5480.60
256_C313_K0.5480.60
372_R379_K0.5470.60
282_L285_S0.5460.60
171_K174_T0.5450.59
172_G175_P0.5440.59
205_Y209_L0.5430.59
314_N331_Y0.5430.59
157_K307_A0.5430.59
278_I282_L0.5420.59
90_L317_V0.5420.59
296_M374_F0.5400.59
414_F417_N0.5400.59
148_R182_L0.5400.59
33_L48_Q0.5390.59
148_R152_A0.5390.59
286_S291_D0.5380.59
129_L225_A0.5360.58
74_R328_T0.5350.58
155_Q254_D0.5350.58
10_N104_I0.5340.58
61_F350_L0.5340.58
8_M11_Q0.5340.58
33_L36_R0.5300.57
297_K398_M0.5300.57
63_N183_P0.5290.57
404_D416_E0.5290.57
111_T244_R0.5290.57
78_R183_P0.5290.57
184_I196_L0.5280.57
156_E315_F0.5270.57
88_D91_S0.5260.57
254_D335_S0.5260.57
130_T356_L0.5260.57
83_S88_D0.5260.57
28_Y32_W0.5260.57
215_L411_P0.5250.57
55_D322_G0.5240.57
125_L225_A0.5240.57
181_K309_D0.5230.56
297_K333_I0.5230.56
200_V336_A0.5230.56
75_I101_V0.5230.56
236_F332_D0.5230.56
400_P404_D0.5220.56
352_L356_L0.5210.56
217_V294_D0.5210.56
315_F378_A0.5200.56
328_T374_F0.5200.56
9_N248_L0.5200.56
274_G277_R0.5200.56
72_R263_S0.5200.56
203_E331_Y0.5190.56
62_D72_R0.5180.56
106_E290_K0.5160.55
6_T101_V0.5160.55
215_L379_K0.5160.55
397_R408_T0.5150.55
261_L271_G0.5150.55
252_Q273_P0.5150.55
257_Q335_S0.5150.55
63_N156_E0.5130.55
182_L310_G0.5130.55
5_V110_V0.5100.55
131_A134_A0.5100.55
203_E236_F0.5100.55
335_S339_V0.5090.54
122_E303_W0.5090.54
167_W178_H0.5080.54
72_R184_I0.5080.54
152_A310_G0.5080.54
142_R199_S0.5080.54
181_K307_A0.5070.54
306_G331_Y0.5070.54
101_V172_G0.5060.54
61_F103_L0.5060.54
129_L230_A0.5050.54
33_L51_N0.5050.54
87_F91_S0.5040.54
214_G374_F0.5030.54
69_P156_E0.5030.54
6_T61_F0.5020.53
149_I152_A0.5020.53
76_V89_L0.5020.53
198_Q201_D0.5010.53
31_E416_E0.5010.53
298_F333_I0.5000.53
203_E309_D0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tpdA 1 0.8977 100 0.175 Contact Map
4pu5A 1 0.9295 100 0.21 Contact Map
3akjA 2 0.525 100 0.614 Contact Map
4hneA 6 0.6682 97.5 0.926 Contact Map
1cjaA 1 0.6886 96.8 0.933 Contact Map
4wtvA 1 0.6114 96.2 0.938 Contact Map
4orkA 1 0.6068 84.8 0.955 Contact Map
3jr1A 1 0.5841 81.8 0.957 Contact Map
3dxpA 2 0.6295 76.3 0.959 Contact Map
1nd4A 2 0.5114 71.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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