GREMLIN Database
HIPB - Antitoxin HipB
UniProt: P23873 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10442
Length: 88 (83)
Sequences: 127 (94)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_Q87_E4.3010.99
8_Y73_A2.5890.87
14_A22_Q2.3510.81
55_T67_S2.1920.76
40_A45_F2.0660.71
7_I71_C1.8940.64
12_Q44_N1.8080.60
18_K67_S1.8060.60
32_A59_K1.7680.59
62_Q73_A1.7460.58
20_V42_I1.7200.56
38_K72_D1.6980.55
14_A38_K1.6670.54
45_F49_P1.5840.50
9_S82_E1.5540.49
11_T76_A1.5300.48
32_A45_F1.4890.46
18_K59_K1.4830.45
76_A80_S1.4630.44
22_Q44_N1.4600.44
18_K69_T1.4100.42
5_Q62_Q1.3960.41
12_Q34_K1.3740.40
57_F67_S1.3120.38
48_N65_E1.2990.37
45_F58_F1.2700.36
45_F56_T1.2700.36
37_I44_N1.2690.36
70_L79_E1.2310.34
23_Q47_N1.2260.34
17_M70_L1.2150.34
14_A49_P1.2040.33
57_F61_L1.1620.31
77_S80_S1.1540.31
25_G83_Q1.1440.31
70_L82_E1.1200.30
27_T66_L1.1090.29
37_I42_I1.0990.29
31_L38_K1.0720.28
19_L55_T1.0480.27
30_E33_K1.0470.27
9_S39_Q1.0280.26
54_L83_Q1.0220.26
10_P50_D1.0180.26
7_I51_N0.9840.25
82_E85_N0.9640.24
5_Q8_Y0.9590.24
76_A82_E0.9380.23
24_N53_T0.9290.23
39_Q87_E0.9170.22
33_K57_F0.9170.22
22_Q26_W0.9130.22
75_N84_Q0.9060.22
12_Q86_L0.8980.22
25_G74_K0.8920.22
45_F59_K0.8880.21
60_I82_E0.8790.21
75_N78_P0.8690.21
63_S66_L0.8660.21
17_M86_L0.8650.21
76_A84_Q0.8580.21
7_I36_G0.8390.20
35_I86_L0.8390.20
14_A45_F0.8290.20
8_Y31_L0.8280.20
65_E71_C0.8260.20
50_D64_L0.8210.19
8_Y62_Q0.8140.19
35_I51_N0.8090.19
65_E72_D0.7990.19
11_T80_S0.7980.19
22_Q53_T0.7800.18
23_Q70_L0.7750.18
6_K35_I0.7670.18
63_S84_Q0.7670.18
15_N64_L0.7600.18
26_W62_Q0.7460.17
8_Y19_L0.7420.17
5_Q55_T0.7390.17
6_K70_L0.7330.17
11_T25_G0.7220.17
16_A38_K0.7190.17
20_V57_F0.7170.17
15_N53_T0.7160.17
14_A48_N0.7100.16
75_N79_E0.6990.16
14_A31_L0.6820.16
22_Q31_L0.6720.15
12_Q36_G0.6700.15
42_I60_I0.6690.15
8_Y12_Q0.6670.15
34_K51_N0.6660.15
10_P25_G0.6650.15
18_K74_K0.6610.15
23_Q65_E0.6570.15
74_K77_S0.6550.15
32_A56_T0.6540.15
32_A58_F0.6540.15
38_K49_P0.6480.15
19_L40_A0.6450.15
39_Q52_T0.6330.15
25_G78_P0.6280.14
48_N76_A0.6260.14
53_T66_L0.6180.14
42_I85_N0.6100.14
30_E80_S0.6040.14
34_K50_D0.5810.13
83_Q86_L0.5730.13
16_A51_N0.5730.13
19_L62_Q0.5620.13
40_A69_T0.5530.13
19_L42_I0.5490.13
6_K36_G0.5450.13
17_M27_T0.5350.12
12_Q40_A0.5340.12
22_Q69_T0.5320.12
42_I67_S0.5190.12
18_K57_F0.5180.12
27_T50_D0.5180.12
9_S29_S0.5060.12
32_A40_A0.5050.12
20_V59_K0.5040.12
78_P82_E0.5020.12
19_L38_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wiuB 2 0.8182 99.3 0.655 Contact Map
3ivpA 2 0.9886 98.8 0.714 Contact Map
4yarA 2 0.9659 98.8 0.717 Contact Map
4pu7B 2 0.7386 98.8 0.718 Contact Map
4y42A 6 0.9659 98.8 0.718 Contact Map
2b5aA 2 0.875 98.7 0.726 Contact Map
1y9qA 1 0.9545 98.7 0.726 Contact Map
4mcxA 2 0.9545 98.7 0.726 Contact Map
4mctA 2 0.9432 98.7 0.726 Contact Map
2o38A 2 0.9205 98.7 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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