GREMLIN Database
AES - Acetyl esterase
UniProt: P23872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11101
Length: 319 (260)
Sequences: 10135 (7803)
Seq/√Len: 483.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_T137_E4.1511.00
90_L138_I3.5661.00
87_L162_A3.4031.00
160_G190_G3.1151.00
86_T154_I2.9621.00
129_A133_Q2.7001.00
148_Q151_D2.6711.00
285_K310_D2.5251.00
142_C188_V2.5251.00
269_R286_L2.5131.00
95_F169_M2.3311.00
119_I145_F2.1591.00
287_Y310_D2.1271.00
88_F141_A2.1251.00
194_W311_G2.0811.00
144_Y148_Q2.0791.00
258_G268_S2.0731.00
272_Y284_F2.0321.00
272_Y282_C2.0051.00
275_L280_Q1.9921.00
76_L119_I1.9861.00
117_T154_I1.9711.00
190_G314_F1.9641.00
155_N158_R1.9391.00
100_L122_D1.9331.00
177_W181_K1.9311.00
192_L311_G1.9121.00
104_D108_R1.8741.00
256_I272_Y1.8161.00
172_L271_L1.8101.00
177_W239_Y1.7971.00
183_I186_G1.7951.00
191_V254_C1.7811.00
103_H164_D1.7771.00
269_R284_F1.7691.00
113_Y309_R1.7611.00
175_A191_V1.7461.00
139_V177_W1.7401.00
86_T145_F1.7331.00
75_R100_L1.7281.00
138_I174_S1.7181.00
121_I141_A1.7101.00
273_Q277_A1.7081.00
88_F142_C1.7081.00
107_M118_V1.6931.00
89_Y162_A1.6891.00
87_L116_C1.6621.00
136_E177_W1.6371.00
139_V178_L1.6271.00
206_R266_D1.6211.00
191_V271_L1.6111.00
78_C117_T1.6041.00
86_T119_I1.5841.00
258_G286_L1.5821.00
109_L113_Y1.5811.00
160_G315_F1.5671.00
135_I173_A1.5461.00
123_Y166_A1.5461.00
195_Y293_A1.5121.00
172_L193_L1.5041.00
162_A192_L1.4881.00
111_A118_V1.4861.00
258_G284_F1.4521.00
190_G255_F1.4451.00
62_A65_V1.4431.00
75_R104_D1.4311.00
68_K140_A1.4261.00
90_L121_I1.4051.00
254_C275_L1.3981.00
113_Y312_A1.3971.00
161_F171_A1.3961.00
64_M71_Q1.3891.00
193_L196_G1.3841.00
276_A282_C1.3761.00
255_F285_K1.3761.00
142_C174_S1.3711.00
301_M304_A1.3691.00
256_I268_S1.3601.00
223_M227_A1.3591.00
95_F197_L1.3571.00
63_Y74_T1.3531.00
74_T119_I1.3511.00
260_E288_P1.3291.00
229_L240_Y1.3221.00
91_H125_L1.3031.00
179_R250_E1.2801.00
88_F145_F1.2721.00
180_D239_Y1.2661.00
272_Y276_A1.2621.00
273_Q276_A1.2611.00
73_E122_D1.2561.00
76_L117_T1.2471.00
74_T141_A1.2461.00
200_L241_C1.2461.00
89_Y103_H1.2381.00
255_F314_F1.2381.00
218_Q222_Q1.2331.00
63_Y66_P1.2251.00
143_C147_Q1.1921.00
270_L273_Q1.1911.00
195_Y295_L1.1861.00
146_H159_I1.1831.00
309_R313_Q1.1831.00
274_T277_A1.1791.00
139_V143_C1.1791.00
303_T306_E1.1681.00
86_T117_T1.1631.00
131_F237_S1.1621.00
253_P281_P1.1541.00
205_T209_L1.1481.00
131_F240_Y1.1471.00
294_F307_A1.1451.00
283_E310_D1.1441.00
274_T278_H1.1351.00
107_M120_G1.1311.00
176_L245_N1.1311.00
209_L265_L1.1241.00
67_T70_G1.1211.00
290_T303_T1.1121.00
171_A193_L1.1101.00
138_I170_L1.0991.00
265_L269_R1.0991.00
175_A188_V1.0791.00
134_A170_L1.0651.00
287_Y294_F1.0591.00
131_F228_Y1.0541.00
199_G244_N1.0481.00
77_F104_D1.0461.00
258_G269_R1.0451.00
126_S129_A1.0421.00
62_A75_R1.0331.00
143_C183_I1.0251.00
133_Q137_E1.0211.00
172_L191_V1.0201.00
142_C178_L1.0191.00
169_M173_A1.0151.00
124_T129_A1.0121.00
217_T220_D1.0091.00
197_L221_L1.0031.00
143_C181_K1.0001.00
142_C146_H0.9861.00
206_R210_G0.9841.00
149_A154_I0.9811.00
130_R134_A0.9701.00
270_L274_T0.9701.00
85_A116_C0.9691.00
149_A156_M0.9661.00
166_A170_L0.9621.00
87_L160_G0.9591.00
89_Y107_M0.9571.00
139_V181_K0.9481.00
135_I177_W0.9441.00
198_Y271_L0.9411.00
234_D237_S0.9401.00
114_S312_A0.9361.00
260_E289_G0.9311.00
171_A191_V0.9281.00
131_F239_Y0.9241.00
176_L239_Y0.9231.00
95_F166_A0.9191.00
172_L198_Y0.9171.00
266_D269_R0.9161.00
230_S234_D0.9141.00
216_L221_L0.9131.00
257_A307_A0.9111.00
193_L256_I0.9031.00
260_E286_L0.9001.00
248_T274_T0.8951.00
265_L286_L0.8951.00
149_A152_Y0.8941.00
134_A228_Y0.8931.00
89_Y164_D0.8861.00
85_A155_N0.8821.00
199_G241_C0.8801.00
164_D195_Y0.8741.00
84_P155_N0.8721.00
255_F310_D0.8721.00
90_L174_S0.8721.00
107_M111_A0.8701.00
79_P117_T0.8691.00
84_P117_T0.8671.00
287_Y307_A0.8561.00
124_T133_Q0.8551.00
161_F174_S0.8551.00
230_S235_R0.8511.00
130_R230_S0.8511.00
200_L225_E0.8501.00
169_M228_Y0.8471.00
201_R244_N0.8401.00
195_Y262_D0.8391.00
57_E80_Q0.8391.00
202_D207_R0.8381.00
90_L161_F0.8311.00
241_C244_N0.8301.00
66_P71_Q0.8221.00
168_A196_G0.8171.00
231_N234_D0.8121.00
225_E240_Y0.8101.00
306_E310_D0.8081.00
96_I126_S0.8061.00
259_A294_F0.8041.00
77_F107_M0.8041.00
161_F191_V0.8021.00
310_D313_Q0.7991.00
275_L282_C0.7981.00
130_R133_Q0.7961.00
229_L235_R0.7951.00
139_V174_S0.7941.00
205_T208_L0.7921.00
177_W180_D0.7891.00
90_L142_C0.7881.00
269_R273_Q0.7841.00
75_R120_G0.7831.00
86_T159_I0.7821.00
173_A239_Y0.7771.00
54_G57_E0.7741.00
97_L224_Y0.7741.00
290_T294_F0.7741.00
197_L225_E0.7711.00
63_Y76_L0.7691.00
106_I295_L0.7531.00
131_F134_A0.7521.00
160_G189_A0.7521.00
293_A296_H0.7501.00
208_L218_Q0.7461.00
148_Q152_Y0.7441.00
258_G265_L0.7431.00
245_N248_T0.7431.00
156_M159_I0.7411.00
196_G268_S0.7391.00
168_A193_L0.7381.00
74_T144_Y0.7371.00
74_T121_I0.7301.00
93_G98_G0.7281.00
67_T71_Q0.7261.00
77_F100_L0.7261.00
65_V72_V0.7251.00
175_A254_C0.7221.00
88_F174_S0.7211.00
61_R78_C0.7201.00
236_E244_N0.7181.00
165_S292_H0.7181.00
72_V141_A0.7171.00
210_G213_W0.7151.00
247_L278_H0.7111.00
100_L120_G0.7081.00
287_Y290_T0.7041.00
220_D224_Y0.7031.00
99_N125_L0.6971.00
103_H106_I0.6931.00
90_L171_A0.6921.00
145_F154_I0.6921.00
204_V207_R0.6911.00
214_D217_T0.6841.00
144_Y152_Y0.6821.00
199_G267_D0.6821.00
121_I138_I0.6821.00
135_I174_S0.6801.00
219_Q222_Q0.6781.00
126_S134_A0.6781.00
192_L315_F0.6781.00
85_A158_R0.6741.00
139_V183_I0.6731.00
257_A294_F0.6721.00
232_D235_R0.6701.00
247_L274_T0.6691.00
100_L107_M0.6681.00
255_F283_E0.6671.00
194_W295_L0.6641.00
122_D125_L0.6631.00
203_S208_L0.6621.00
86_T149_A0.6611.00
212_V217_T0.6561.00
75_R101_D0.6531.00
65_V74_T0.6521.00
305_D309_R0.6491.00
98_G125_L0.6471.00
134_A137_E0.6431.00
299_R305_D0.6421.00
206_R209_L0.6411.00
99_N102_T0.6381.00
59_A78_C0.6351.00
257_A287_Y0.6331.00
256_I271_L0.6311.00
89_Y120_G0.6271.00
96_I227_A0.6221.00
67_T72_V0.6190.99
73_E100_L0.6190.99
146_H186_G0.6180.99
271_L275_L0.6160.99
77_F120_G0.6160.99
276_A284_F0.6150.99
162_A194_W0.6150.99
116_C162_A0.6120.99
178_L183_I0.6080.99
172_L254_C0.6070.99
257_A285_K0.6020.99
55_A59_A0.6020.99
176_L251_V0.6000.99
176_L179_R0.5990.99
190_G253_P0.5990.99
208_L211_G0.5980.99
55_A58_M0.5980.99
72_V121_I0.5950.99
150_E156_M0.5930.99
254_C271_L0.5920.99
126_S132_P0.5910.99
298_S304_A0.5910.99
164_D295_L0.5910.99
95_F170_L0.5860.99
89_Y194_W0.5850.99
195_Y259_A0.5850.99
230_S233_A0.5830.99
183_I187_K0.5810.99
140_A143_C0.5800.99
94_G224_Y0.5750.99
213_W217_T0.5730.99
99_N122_D0.5720.99
306_E309_R0.5700.99
61_R65_V0.5690.99
198_Y243_F0.5680.99
259_A290_T0.5660.99
214_D261_F0.5660.99
191_V251_V0.5640.99
79_P115_Q0.5640.99
136_E140_A0.5630.99
106_I308_L0.5630.99
290_T301_M0.5620.99
251_V254_C0.5610.99
155_N189_A0.5570.99
63_Y151_D0.5550.99
135_I170_L0.5550.99
64_M73_E0.5540.99
57_E112_S0.5520.99
178_L188_V0.5520.99
302_K306_E0.5510.99
251_V271_L0.5500.99
161_F175_A0.5490.99
211_G218_Q0.5480.99
84_P115_Q0.5480.99
110_L118_V0.5450.99
211_G214_D0.5440.99
241_C245_N0.5440.99
70_G140_A0.5430.99
176_L248_T0.5410.99
164_D194_W0.5400.99
304_A308_L0.5390.99
193_L198_Y0.5390.99
109_L112_S0.5380.99
59_A80_Q0.5370.99
203_S207_R0.5370.99
175_A251_V0.5360.99
83_S155_N0.5350.99
220_D223_M0.5320.98
302_K305_D0.5320.98
267_D270_L0.5300.98
90_L170_L0.5290.98
132_P136_E0.5280.98
65_V68_K0.5270.98
299_R304_A0.5270.98
158_R189_A0.5270.98
133_Q136_E0.5240.98
146_H183_I0.5240.98
176_L271_L0.5230.98
90_L145_F0.5230.98
73_E101_D0.5220.98
222_Q226_E0.5210.98
213_W216_L0.5200.98
204_V210_G0.5200.98
66_P69_Y0.5200.98
149_A153_Q0.5180.98
282_C286_L0.5140.98
103_H296_H0.5140.98
65_V70_G0.5110.98
198_Y267_D0.5100.98
199_G204_V0.5080.98
136_E181_K0.5070.98
67_T140_A0.5070.98
175_A252_P0.5050.98
98_G102_T0.5050.98
243_F274_T0.5050.98
311_G315_F0.5040.98
191_V252_P0.5040.98
244_N247_L0.5030.98
197_L200_L0.5030.98
202_D222_Q0.5010.98
142_C159_I0.5010.98
221_L225_E0.5010.98
264_L267_D0.5010.98
295_L308_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hm7A 2 0.9498 100 0.35 Contact Map
4wy8A 2 0.9592 100 0.352 Contact Map
1lzlA 1 0.953 100 0.355 Contact Map
3zwqA 4 0.9498 100 0.369 Contact Map
2c7bA 3 0.8934 100 0.377 Contact Map
3ga7A 1 0.9592 100 0.379 Contact Map
3wj1A 4 0.9373 100 0.387 Contact Map
4ob7A 2 0.9687 100 0.39 Contact Map
4wy5A 2 0.9655 100 0.407 Contact Map
4j7aA 2 0.9843 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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