GREMLIN Database
HEMH - Ferrochelatase
UniProt: P23871 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10431
Length: 320 (306)
Sequences: 3136 (1852)
Seq/√Len: 105.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_N221_A3.7751.00
90_R310_E3.5161.00
193_Y215_T3.3881.00
80_S98_L3.1311.00
198_Q202_D3.0451.00
82_Q304_A3.0221.00
97_A113_E2.9501.00
188_L230_M2.9481.00
241_P244_M2.8461.00
46_W50_R2.7541.00
285_R289_L2.7051.00
86_A306_P2.6871.00
17_D104_S2.5171.00
161_D210_R2.4811.00
198_Q241_P2.4221.00
142_E145_R2.4211.00
174_N307_E2.2831.00
251_L262_I2.2491.00
253_M257_K2.2141.00
260_G294_K2.1471.00
90_R313_A2.1421.00
18_A23_A2.1351.00
11_A139_V2.1251.00
178_A305_T2.0931.00
83_Q309_I2.0441.00
112_D116_A2.0421.00
29_K50_R2.0371.00
219_A229_V2.0151.00
97_A117_E1.9821.00
97_A114_L1.9621.00
201_A208_P1.9171.00
199_R240_E1.9141.00
266_C280_I1.8891.00
164_D213_T1.8771.00
121_H155_G1.7931.00
167_D314_N1.7911.00
42_R46_W1.7911.00
177_R221_A1.7901.00
215_T231_M1.7581.00
216_R220_S1.7521.00
225_A228_K1.7211.00
86_A309_I1.7111.00
232_T247_T1.7081.00
213_T217_E1.6981.00
191_L218_L1.6891.00
250_T253_M1.6661.00
101_S138_A1.6631.00
176_V265_M1.6581.00
104_S109_S1.6251.00
212_R233_F1.6231.00
6_T121_H1.6171.00
95_P117_E1.6101.00
209_Q213_T1.5991.00
73_G78_V1.5891.00
124_V143_L1.5781.00
87_L309_I1.5361.00
77_M81_R1.5271.00
208_P212_R1.5261.00
249_E252_K1.5251.00
191_L229_V1.5111.00
213_T216_R1.5081.00
145_R148_A1.4891.00
72_G82_Q1.4801.00
162_Y270_A1.4631.00
193_Y231_M1.4351.00
191_L265_M1.4341.00
33_S46_W1.4331.00
113_E117_E1.4291.00
169_I221_A1.4241.00
230_M250_T1.4181.00
55_P58_S1.4171.00
168_Y172_L1.4051.00
15_T77_M1.3851.00
172_L218_L1.3741.00
281_A298_Y1.3741.00
86_A304_A1.3691.00
99_G110_A1.3531.00
79_Y271_A1.3470.99
251_L284_N1.3460.99
166_H221_A1.3390.99
24_V61_V1.3340.99
196_I200_Y1.3340.99
208_P233_F1.3190.99
78_V82_Q1.3140.99
215_T229_V1.3050.99
114_L122_I1.3020.99
175_S305_T1.3010.99
110_A113_E1.3000.99
17_D26_R1.2870.99
140_W158_F1.2800.99
30_Q142_E1.2770.99
110_A114_L1.2710.99
7_G119_V1.2680.99
88_A92_P1.2520.99
7_G114_L1.2430.99
174_N177_R1.2420.99
97_A110_A1.2410.99
85_Q89_Q1.2410.99
248_D287_V1.2380.99
232_T250_T1.2360.99
196_I201_A1.2330.99
286_E289_L1.2320.99
165_N315_L1.2230.99
191_L219_A1.2140.99
17_D23_A1.2120.99
72_G78_V1.2080.99
169_I217_E1.2010.99
179_S297_E1.2000.99
173_A221_A1.1990.99
180_F263_Q1.1970.99
35_R42_R1.1950.99
263_Q297_E1.1930.99
87_L313_A1.1880.99
84_Q88_A1.1850.99
236_R246_Y1.1840.99
7_G110_A1.1830.99
52_V56_L1.1800.99
173_A177_R1.1780.99
163_A210_R1.1760.99
217_E220_S1.1710.99
170_N174_N1.1680.99
285_R296_Y1.1560.98
125_L312_M1.1510.98
188_L259_V1.1500.98
185_E228_K1.1430.98
179_S182_K1.1410.98
172_L302_L1.1370.98
270_A308_H1.1360.98
313_A317_A1.1340.98
252_K287_V1.1320.98
311_M315_L1.1310.98
114_L119_V1.1260.98
272_D303_N1.1260.98
79_Y304_A1.1250.98
201_A209_Q1.1250.98
48_L52_V1.1210.98
84_Q98_L1.1070.98
85_Q88_A1.1000.98
63_K66_A1.0920.98
21_P24_V1.0850.98
277_L281_A1.0850.98
175_S300_P1.0830.98
56_L60_R1.0810.98
22_E26_R1.0760.98
121_H157_S1.0730.97
224_M228_K1.0730.97
40_T44_L1.0570.97
215_T219_A1.0550.97
81_R85_Q1.0540.97
39_D151_R1.0420.97
192_S234_Q1.0390.97
29_K33_S1.0390.97
119_V122_I1.0350.97
252_K290_G1.0320.97
140_W144_A1.0260.97
162_Y308_H1.0240.97
176_V189_L1.0230.97
112_D146_I1.0230.97
163_A217_E1.0200.97
284_N287_V1.0180.97
86_A89_Q1.0120.96
33_S50_R1.0100.96
87_L312_M1.0090.96
165_N314_N1.0080.96
59_P63_K1.0080.96
286_E290_G1.0060.96
77_M98_L1.0020.96
188_L257_K1.0000.96
261_H294_K0.9960.96
264_V296_Y0.9950.96
190_L262_I0.9790.96
167_D170_N0.9780.96
187_D260_G0.9770.96
125_L159_I0.9700.95
54_L58_S0.9670.95
266_C298_Y0.9660.95
190_L230_M0.9660.95
173_A218_L0.9630.95
187_D263_Q0.9630.95
107_L139_V0.9620.95
283_Q287_V0.9600.95
244_M249_E0.9590.95
123_V316_V0.9570.95
167_D310_E0.9520.95
134_S196_I0.9500.95
39_D199_R0.9470.95
172_L265_M0.9360.94
199_R203_E0.9350.94
164_D217_E0.9290.94
8_I316_V0.9240.94
130_Q211_C0.9190.94
114_L117_E0.9110.94
45_W49_L0.9100.94
186_P260_G0.9090.94
171_A302_L0.9060.93
187_D261_H0.9030.93
176_V218_L0.9000.93
81_R98_L0.8960.93
107_L142_E0.8930.93
132_S200_Y0.8920.93
67_S282_E0.8920.93
189_L265_M0.8910.93
288_F293_G0.8840.93
123_V159_I0.8840.93
7_G97_A0.8820.92
252_K256_E0.8820.92
251_L291_A0.8810.92
112_D115_L0.8790.92
186_P261_H0.8750.92
281_A285_R0.8730.92
43_L47_P0.8720.92
91_L313_A0.8660.92
180_F185_E0.8640.92
83_Q312_M0.8600.92
170_N307_E0.8510.91
167_D307_E0.8460.91
115_L150_K0.8460.91
52_V55_P0.8450.91
124_V158_F0.8450.91
146_I150_K0.8430.91
67_S278_E0.8420.91
18_A22_E0.8410.91
191_L215_T0.8410.91
45_W55_P0.8410.91
280_I296_Y0.8370.90
6_T123_V0.8370.90
123_V157_S0.8260.90
172_L176_V0.8240.90
21_P59_P0.8240.90
79_Y303_N0.8230.90
172_L175_S0.8180.89
48_L53_I0.8170.89
18_A21_P0.8150.89
142_E146_I0.8140.89
175_S178_A0.8100.89
79_Y82_Q0.8040.89
172_L214_T0.8020.88
48_L58_S0.8020.88
127_L270_A0.8010.88
182_K297_E0.8000.88
108_E149_R0.8000.88
177_R181_A0.7970.88
169_I214_T0.7940.88
255_G291_A0.7920.88
56_L59_P0.7880.88
25_K58_S0.7880.88
255_G259_V0.7870.87
255_G293_G0.7870.87
144_A158_F0.7850.87
82_Q85_Q0.7840.87
167_D311_M0.7830.87
7_G99_G0.7830.87
252_K291_A0.7820.87
9_L110_A0.7810.87
186_P263_Q0.7800.87
214_T218_L0.7800.87
29_K46_W0.7780.87
193_Y211_C0.7750.87
57_R238_G0.7740.87
36_R141_D0.7720.86
190_L232_T0.7710.86
111_V115_L0.7650.86
251_L296_Y0.7640.86
39_D133_C0.7610.86
209_Q212_R0.7590.86
108_E146_I0.7590.86
101_S142_E0.7570.85
255_G260_G0.7540.85
264_V280_I0.7520.85
125_L316_V0.7490.85
179_S300_P0.7490.85
183_H187_D0.7490.85
11_A107_L0.7470.85
209_Q216_R0.7450.84
255_G258_G0.7410.84
21_P62_A0.7410.84
212_R231_M0.7390.84
55_P59_P0.7390.84
178_A182_K0.7350.84
134_S200_Y0.7290.83
255_G294_K0.7280.83
42_R50_R0.7270.83
82_Q86_A0.7270.83
284_N301_A0.7230.83
137_G141_D0.7210.82
155_G160_R0.7200.82
111_V146_I0.7200.82
122_I154_P0.7180.82
30_Q103_G0.7170.82
38_V200_Y0.7160.82
112_D150_K0.7150.82
262_I293_G0.7120.82
146_I149_R0.7070.81
308_H311_M0.7050.81
287_V290_G0.7040.81
88_A95_P0.6970.80
30_Q106_S0.6960.80
250_T254_L0.6930.80
80_S84_Q0.6890.80
179_S183_H0.6800.79
27_Y31_F0.6800.79
83_Q91_L0.6780.78
178_A300_P0.6770.78
133_C137_G0.6770.78
188_L228_K0.6740.78
281_A284_N0.6730.78
180_F189_L0.6710.78
111_V122_I0.6710.78
187_D259_V0.6690.78
9_L99_G0.6680.77
25_K55_P0.6680.77
174_N178_A0.6670.77
89_Q116_A0.6660.77
313_A316_V0.6640.77
169_I173_A0.6620.77
95_P99_G0.6600.77
64_L278_E0.6590.76
50_R55_P0.6570.76
106_S109_S0.6570.76
21_P26_R0.6550.76
284_N296_Y0.6550.76
169_I218_L0.6540.76
84_Q96_V0.6530.76
163_A213_T0.6520.76
190_L250_T0.6510.76
272_D301_A0.6490.75
310_E314_N0.6470.75
43_L46_W0.6470.75
31_F273_C0.6450.75
309_I312_M0.6450.75
115_L152_S0.6440.75
27_Y61_V0.6430.75
109_S112_D0.6420.75
201_A216_R0.6380.74
40_T43_L0.6380.74
250_T257_K0.6370.74
111_V150_K0.6370.74
188_L262_I0.6340.74
248_D284_N0.6340.74
175_S265_M0.6340.74
217_E221_A0.6340.74
11_A99_G0.6320.73
282_E286_E0.6310.73
308_H312_M0.6300.73
15_T74_S0.6290.73
183_H297_E0.6290.73
180_F186_P0.6280.73
29_K55_P0.6260.73
27_Y30_Q0.6260.73
53_I57_R0.6240.73
263_Q299_I0.6230.72
98_L110_A0.6230.72
68_V278_E0.6220.72
165_N311_M0.6210.72
124_V156_I0.6190.72
130_Q135_T0.6180.72
99_G139_V0.6170.72
90_R306_P0.6150.71
60_R64_L0.6150.71
47_P50_R0.6130.71
208_P243_L0.6130.71
180_F183_H0.6120.71
287_V291_A0.6110.71
183_H263_Q0.6100.71
83_Q271_A0.6100.71
36_R137_G0.6090.71
6_T94_M0.6080.71
9_L107_L0.6060.70
178_A307_E0.6050.70
35_R46_W0.6050.70
278_E282_E0.6040.70
34_D102_Y0.6040.70
190_L247_T0.6030.70
195_G244_M0.6020.70
40_T239_R0.6010.70
178_A181_A0.6010.70
171_A311_M0.5990.69
177_R222_L0.5990.69
41_S46_W0.5980.69
111_V143_L0.5960.69
310_E313_A0.5950.69
120_D155_G0.5940.69
63_K283_Q0.5930.69
256_E260_G0.5920.69
64_L274_L0.5900.68
253_M256_E0.5900.68
139_V142_E0.5880.68
200_Y240_E0.5880.68
201_A213_T0.5850.68
91_L94_M0.5850.68
261_H297_E0.5840.68
175_S299_I0.5830.67
24_V62_A0.5820.67
11_A124_V0.5800.67
232_T262_I0.5780.67
10_L87_L0.5780.67
127_L271_A0.5760.66
28_L57_R0.5740.66
9_L111_V0.5720.66
26_R104_S0.5710.66
88_A96_V0.5700.66
90_R309_I0.5700.66
115_L147_L0.5700.66
113_E116_A0.5680.65
13_L128_Y0.5670.65
87_L316_V0.5660.65
224_M229_V0.5640.65
195_G246_Y0.5640.65
18_A26_R0.5640.65
138_A153_I0.5610.64
166_H170_N0.5610.64
62_A66_A0.5590.64
276_T279_E0.5540.63
212_R216_R0.5540.63
188_L254_L0.5500.63
83_Q87_L0.5490.63
166_H217_E0.5470.63
108_E145_R0.5450.62
176_V299_I0.5440.62
30_Q108_E0.5440.62
298_Y301_A0.5430.62
61_V64_L0.5430.62
51_G55_P0.5410.62
174_N305_T0.5410.62
108_E112_D0.5410.62
210_R213_T0.5390.61
249_E287_V0.5390.61
307_E310_E0.5360.61
106_S110_A0.5360.61
280_I283_Q0.5360.61
47_P52_V0.5350.61
40_T46_W0.5340.61
47_P51_G0.5320.60
186_P297_E0.5320.60
208_P213_T0.5310.60
201_A233_F0.5310.60
83_Q86_A0.5300.60
61_V138_A0.5290.60
8_I94_M0.5210.59
152_S209_Q0.5190.59
89_Q310_E0.5180.58
314_N317_A0.5180.58
95_P119_V0.5180.58
171_A307_E0.5180.58
189_L222_L0.5170.58
289_L294_K0.5160.58
131_F137_G0.5140.58
59_P62_A0.5140.58
207_Y234_Q0.5140.58
30_Q101_S0.5130.58
143_L147_L0.5130.58
97_A119_V0.5120.57
183_H261_H0.5120.57
213_T220_S0.5040.56
216_R219_A0.5020.56
39_D240_E0.5010.56
39_D200_Y0.5000.56
13_L37_V0.5000.56
219_A223_G0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lbqA 2 0.9656 100 0.215 Contact Map
3hcnA 2 0.9719 100 0.228 Contact Map
2h1vA 1 0.9219 100 0.286 Contact Map
2xwpA 5 0.7719 100 0.598 Contact Map
2xvyA 3 0.7406 100 0.664 Contact Map
4ccsA 1 0.6906 99.8 0.807 Contact Map
2jh3A 2 0.75 99.6 0.838 Contact Map
3lyhA 2 0.3719 99.6 0.845 Contact Map
1tjnA 4 0.3563 99.5 0.854 Contact Map
2xwsA 2 0.3625 99.4 0.859 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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