GREMLIN Database
PPIB - Peptidyl-prolyl cis-trans isomerase B
UniProt: P23869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10758
Length: 164 (144)
Sequences: 10365 (5523)
Seq/√Len: 460.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_R134_D3.5301.00
5_H10_D3.0131.00
102_V137_K2.9811.00
12_V128_D2.9261.00
81_G130_M2.6561.00
37_N159_S2.3871.00
79_T125_E2.1481.00
84_A99_F2.1441.00
39_T52_G2.0671.00
29_D33_E2.0061.00
4_F11_I2.0051.00
25_K29_D1.9381.00
78_N84_A1.9241.00
14_K125_E1.8491.00
14_K127_V1.8151.00
5_H158_E1.8051.00
5_H159_S1.7981.00
11_I133_V1.7891.00
4_F160_V1.7821.00
40_I154_D1.7771.00
13_I83_L1.7761.00
4_F13_I1.7611.00
139_V155_V1.6871.00
8_H135_K1.6781.00
15_T24_V1.6591.00
17_D24_V1.6511.00
31_C160_V1.6331.00
22_E69_K1.6141.00
68_I94_A1.5941.00
16_F19_K1.5911.00
50_I102_V1.5701.00
16_F125_E1.5001.00
101_N105_N1.4811.00
82_T101_N1.4681.00
11_I126_V1.4651.00
46_N138_G1.4611.00
46_N137_K1.4461.00
140_A152_K1.4401.00
82_T125_E1.4321.00
19_K75_G1.4231.00
41_F52_G1.3881.00
45_I49_M1.3631.00
68_I71_E1.3581.00
79_T82_T1.3541.00
142_G152_K1.3451.00
28_L32_R1.3371.00
50_I136_I1.2981.00
157_I160_V1.2401.00
44_V136_I1.2341.00
136_I155_V1.2151.00
141_T149_D1.2081.00
4_F157_I1.2061.00
34_G37_N1.1811.00
14_K17_D1.1751.00
82_T122_V1.1721.00
33_E65_K1.1661.00
23_T85_M1.1501.00
23_T123_F1.1431.00
77_K109_N1.1361.00
81_G134_D1.1351.00
13_I100_I1.1301.00
143_R148_Q1.1251.00
35_F55_F1.1251.00
22_E25_K1.1061.00
46_N141_T1.0971.00
134_D137_K1.0891.00
126_V130_M1.0831.00
47_G103_V1.0691.00
84_A109_N1.0491.00
40_I156_I1.0491.00
69_K92_H1.0361.00
142_G148_Q1.0331.00
45_I149_D1.0271.00
78_N82_T1.0061.00
11_I100_I1.0021.00
39_T54_G1.0011.00
12_V127_V0.9971.00
83_L123_F0.9941.00
126_V133_V0.9901.00
130_M133_V0.9861.00
72_A110_F0.9861.00
29_D65_K0.9761.00
140_A149_D0.9711.00
20_A24_V0.9681.00
8_H139_V0.9571.00
102_V133_V0.9531.00
56_E59_M0.9501.00
79_T104_D0.9481.00
100_I133_V0.9431.00
87_R93_S0.9291.00
29_D32_R0.9251.00
77_K106_D0.9241.00
90_A93_S0.9231.00
30_Y33_E0.9141.00
43_R51_Q0.9121.00
35_F61_Q0.9091.00
20_A121_C0.9011.00
87_R120_Y0.8991.00
84_A122_V0.8991.00
25_K28_L0.8871.00
87_R90_A0.8861.00
87_R94_A0.8861.00
70_N87_R0.8691.00
56_E61_Q0.8611.00
70_N94_A0.8611.00
7_N158_E0.8581.00
130_M134_D0.8511.00
132_V135_K0.8501.00
24_V28_L0.8471.00
23_T121_C0.8461.00
78_N109_N0.8341.00
40_I150_V0.8141.00
8_H153_E0.8131.00
67_P95_T0.8131.00
49_M102_V0.8131.00
67_P88_T0.8081.00
80_R103_V0.7951.00
77_K84_A0.7951.00
139_V153_E0.7931.00
73_N110_F0.7901.00
142_G150_V0.7851.00
12_V129_G0.7841.00
44_V50_I0.7641.00
55_F61_Q0.7571.00
13_I126_V0.7541.00
80_R130_M0.7501.00
64_T95_T0.7501.00
29_D34_G0.7461.00
44_V155_V0.7441.00
131_D135_K0.7431.00
27_F123_F0.7331.00
44_V102_V0.7261.00
56_E60_K0.7231.00
51_Q97_Q0.7211.00
7_N156_I0.7191.00
42_H97_Q0.7191.00
22_E68_I0.7181.00
9_G132_V0.7181.00
6_T11_I0.7141.00
19_K76_L0.7131.00
6_T132_V0.7041.00
100_I126_V0.6861.00
49_M107_F0.6861.00
35_F96_A0.6791.00
20_A72_A0.6781.00
85_M94_A0.6751.00
38_N156_I0.6731.00
80_R102_V0.6711.00
63_A66_E0.6691.00
78_N101_N0.6651.00
46_N102_V0.6631.00
103_V107_F0.6581.00
6_T9_G0.6571.00
26_N66_E0.6551.00
20_A73_N0.6551.00
48_F51_Q0.6451.00
51_Q86_A0.6411.00
78_N99_F0.6340.99
141_T152_K0.6310.99
128_D131_D0.6250.99
70_N92_H0.6240.99
129_G132_V0.6200.99
88_T93_S0.6190.99
54_G58_G0.6150.99
80_R104_D0.6120.99
17_D25_K0.6120.99
127_V131_D0.6090.99
106_D109_N0.6010.99
38_N158_E0.5990.99
66_E95_T0.5950.99
79_T109_N0.5950.99
35_F39_T0.5930.99
43_R86_A0.5920.99
149_D152_K0.5890.99
79_T101_N0.5880.99
10_D132_V0.5860.99
8_H155_V0.5820.99
75_G78_N0.5790.99
73_N121_C0.5760.99
8_H132_V0.5750.99
141_T151_P0.5740.99
39_T55_F0.5730.99
62_K66_E0.5630.99
47_G137_K0.5600.99
26_N29_D0.5600.99
135_K138_G0.5590.99
17_D28_L0.5580.99
86_A97_Q0.5560.99
19_K73_N0.5530.99
16_F82_T0.5500.99
55_F95_T0.5480.98
37_N160_V0.5480.98
126_V129_G0.5470.98
44_V151_P0.5460.98
45_I48_F0.5400.98
23_T68_I0.5380.98
50_I100_I0.5350.98
150_V154_D0.5350.98
131_D134_D0.5290.98
140_A143_R0.5220.98
26_N68_I0.5210.98
15_T124_A0.5200.98
102_V134_D0.5180.98
76_L79_T0.5180.98
20_A23_T0.5170.98
25_K64_T0.5150.98
48_F108_L0.5140.98
64_T68_I0.5130.98
151_P155_V0.5120.98
15_T123_F0.5110.98
19_K74_N0.5090.98
55_F60_K0.5080.98
83_L124_A0.5070.98
8_H136_I0.5030.97
70_N120_Y0.5020.97
27_F85_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lopA 1 1 100 0.116 Contact Map
1w74A 1 0.9085 100 0.119 Contact Map
3s6mA 1 0.9756 100 0.123 Contact Map
2k7nA 1 0.9146 100 0.126 Contact Map
1v9tA 1 0.9817 100 0.128 Contact Map
2poeA 1 0.9207 100 0.128 Contact Map
2fu0A 1 0.9085 100 0.129 Contact Map
2b71A 1 0.9024 100 0.129 Contact Map
3bo7A 3 0.9024 100 0.13 Contact Map
1zkcA 1 0.9207 100 0.133 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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