GREMLIN Database
PSPE - Thiosulfate sulfurtransferase PspE
UniProt: P23857 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10780
Length: 104 (94)
Sequences: 10081 (7268)
Seq/√Len: 749.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_T89_E3.0441.00
7_L11_L2.3241.00
22_H61_D2.3061.00
96_D100_P2.2581.00
35_E98_A2.1921.00
8_A11_L2.0871.00
11_L15_L2.0781.00
32_Y36_H2.0431.00
29_P33_Q2.0251.00
9_L96_D1.7881.00
9_L100_P1.7691.00
65_V80_L1.7581.00
49_K53_A1.7131.00
48_V52_I1.6521.00
62_T87_H1.6281.00
12_V23_W1.5541.00
77_K88_V1.4961.00
31_Q72_Q1.4831.00
29_P42_N1.4771.00
26_V76_A1.4651.00
15_L18_F1.4541.00
9_L13_F1.4001.00
51_R54_T1.3971.00
92_G96_D1.3871.00
21_E64_K1.3241.00
73_S90_N1.3171.00
43_I55_A1.2901.00
94_L98_A1.2791.00
58_D61_D1.2701.00
77_K90_N1.2511.00
43_I51_R1.2311.00
36_H66_Y1.2201.00
47_E51_R1.2171.00
51_R55_A1.1991.00
31_Q68_N1.1921.00
15_L21_E1.1791.00
8_A91_A1.1551.00
15_L62_T1.1521.00
38_Q97_I1.1471.00
66_Y94_L1.1371.00
37_V66_Y1.1311.00
7_L12_V1.1201.00
22_H41_I1.1191.00
65_V76_A1.1151.00
77_K81_S1.0981.00
47_E50_E1.0961.00
80_L88_V1.0901.00
27_R68_N1.0761.00
50_E54_T1.0651.00
59_K85_Y1.0531.00
37_V40_A1.0481.00
23_W37_V1.0471.00
65_V88_V1.0441.00
81_S86_T1.0391.00
63_V80_L1.0261.00
23_W66_Y1.0111.00
27_R94_L1.0061.00
65_V77_K1.0061.00
26_V65_V0.9951.00
24_I57_P0.9901.00
28_V31_Q0.9901.00
28_V42_N0.9771.00
69_A95_K0.9511.00
10_A14_S0.9471.00
67_C70_G0.9281.00
12_V15_L0.9281.00
95_K99_M0.9241.00
52_I80_L0.9181.00
95_K98_A0.9131.00
40_A66_Y0.9081.00
67_C73_S0.8941.00
81_S88_V0.8921.00
79_I83_M0.8881.00
96_D99_M0.8821.00
12_V64_K0.8791.00
22_H63_V0.8721.00
7_L89_E0.8611.00
31_Q34_Q0.8481.00
48_V83_M0.8481.00
35_E94_L0.8281.00
74_G90_N0.8071.00
30_E33_Q0.8011.00
36_H42_N0.7961.00
69_A72_Q0.7841.00
21_E62_T0.7801.00
28_V72_Q0.7701.00
63_V85_Y0.7661.00
68_N95_K0.7551.00
78_E82_E0.7461.00
45_L75_Q0.7421.00
13_F16_P0.7381.00
24_I41_I0.7311.00
37_V97_I0.7291.00
32_Y42_N0.7261.00
46_K49_K0.7221.00
11_L14_S0.7121.00
32_Y40_A0.6941.00
48_V79_I0.6841.00
80_L85_Y0.6811.00
68_N71_R0.6801.00
79_I82_E0.6721.00
12_V21_E0.6721.00
31_Q69_A0.6641.00
43_I76_A0.6621.00
24_I76_A0.6571.00
10_A100_P0.6561.00
26_V45_L0.6551.00
81_S87_H0.6451.00
29_P44_P0.6451.00
67_C72_Q0.6411.00
20_A62_T0.6401.00
93_G96_D0.6331.00
52_I56_V0.6001.00
12_V16_P0.5921.00
75_Q82_E0.5861.00
27_R35_E0.5821.00
22_H57_P0.5801.00
17_V20_A0.5791.00
7_L15_L0.5741.00
57_P63_V0.5721.00
36_H40_A0.5691.00
82_E85_Y0.5671.00
67_C93_G0.5631.00
30_E34_Q0.5581.00
56_V85_Y0.5401.00
60_N87_H0.5391.00
85_Y88_V0.5341.00
78_E81_S0.5311.00
22_H62_T0.5291.00
74_G78_E0.5211.00
46_K50_E0.5191.00
7_L21_E0.5171.00
28_V44_P0.5171.00
41_I55_A0.5161.00
24_I80_L0.5141.00
27_R42_N0.5131.00
7_L64_K0.5061.00
32_Y66_Y0.5051.00
53_A59_K0.5041.00
53_A58_D0.5041.00
42_N45_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k0zA 1 0.9615 99.9 0.206 Contact Map
3hzuA 2 1 99.9 0.225 Contact Map
1yt8A 1 0.9712 99.9 0.229 Contact Map
3aayA 1 1 99.9 0.23 Contact Map
1e0cA 1 1 99.9 0.23 Contact Map
1uarA 1 1 99.9 0.23 Contact Map
1urhA 1 0.9808 99.9 0.232 Contact Map
3tp9A 2 0.9808 99.8 0.244 Contact Map
1rhsA 1 1 99.8 0.248 Contact Map
2wlrA 1 1 99.8 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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