GREMLIN Database
TRKG - Trk system potassium uptake protein TrkG
UniProt: P23849 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11020
Length: 485 (404)
Sequences: 5282 (3952)
Seq/√Len: 196.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
413_F463_A4.2521.00
347_G353_C4.2271.00
103_D457_K3.4711.00
200_I214_I3.4031.00
246_G311_F3.4001.00
102_I458_C3.2121.00
203_Y245_A3.1541.00
199_C248_F2.9531.00
139_F196_G2.9331.00
416_V459_L2.7781.00
206_A238_N2.7221.00
327_D330_S2.6391.00
348_C358_S2.4971.00
417_L456_A2.4721.00
229_H235_Y2.4161.00
138_N219_S2.3961.00
231_E235_Y2.3841.00
202_C244_V2.3671.00
423_D426_T2.3561.00
206_A240_L2.3291.00
105_L461_C2.3171.00
135_S215_C2.2861.00
67_L71_D2.2761.00
302_D305_G2.2311.00
128_R132_Y2.1531.00
204_R210_L2.1441.00
102_I461_C2.1141.00
131_L211_F2.1021.00
109_V461_C2.0881.00
206_A244_V2.0451.00
318_L339_L2.0441.00
200_I210_L2.0401.00
219_S323_L2.0331.00
216_H227_S2.0241.00
414_I428_F1.9721.00
291_T295_V1.9481.00
242_E308_I1.9471.00
242_E309_H1.9431.00
99_L125_S1.9321.00
129_A133_Y1.8961.00
246_G315_S1.8881.00
121_D124_S1.8791.00
206_A241_V1.8661.00
68_R71_D1.8491.00
204_R213_A1.8471.00
102_I454_D1.8451.00
253_A319_T1.8261.00
250_L315_S1.8061.00
240_L244_V1.7761.00
416_V455_I1.7741.00
233_I245_A1.7661.00
100_T103_D1.7581.00
304_H308_I1.7571.00
202_C240_L1.7431.00
84_S101_F1.7351.00
221_V252_S1.7341.00
364_L403_F1.7331.00
243_L247_S1.7291.00
340_L432_A1.7201.00
253_A280_F1.7081.00
118_T122_D1.7031.00
413_F459_L1.6931.00
239_Y308_I1.6751.00
282_L286_G1.6611.00
242_E325_T1.6611.00
410_T432_A1.6451.00
289_I338_F1.6401.00
88_A101_F1.6301.00
433_A438_M1.6101.00
243_L308_I1.6001.00
363_I391_V1.5981.00
229_H236_F1.5631.00
122_D125_S1.5401.00
410_T435_I1.5301.00
356_I361_F1.5201.00
186_R190_I1.5201.00
420_M453_N1.5151.00
237_N309_H1.5051.00
220_T245_A1.5041.00
426_T442_F1.4991.00
290_V335_T1.4971.00
200_I217_G1.4901.00
249_S316_S1.4901.00
249_S321_N1.4851.00
285_L289_I1.4781.00
369_K373_N1.4771.00
203_Y241_V1.4761.00
320_D438_M1.4581.00
67_L70_R1.4431.00
414_I431_V1.4411.00
110_S226_F1.4401.00
458_C462_I1.4371.00
88_A92_W1.4371.00
247_S251_L1.4351.00
99_L126_L1.4291.00
243_L304_H1.4211.00
92_W129_A1.4161.00
107_E119_V1.4141.00
215_C228_T1.4101.00
138_N224_G1.4011.00
314_A318_L1.4011.00
102_I457_K1.3891.00
275_I279_F1.3891.00
406_Y435_I1.3771.00
131_L135_S1.3701.00
441_G445_T1.3611.00
101_F105_L1.3561.00
341_L345_F1.3521.00
283_I315_S1.3511.00
208_M241_V1.3501.00
458_C461_C1.3491.00
212_D229_H1.3471.00
328_Y339_L1.3361.00
422_Y444_A1.3341.00
202_C206_A1.3331.00
109_V465_I1.3321.00
84_S109_V1.3311.00
345_F358_S1.3271.00
105_L458_C1.3251.00
99_L120_I1.3181.00
208_M212_D1.3011.00
274_D278_R1.2961.00
123_V230_S1.2951.00
250_L281_L1.2921.00
220_T323_L1.2851.00
430_T445_T1.2821.00
243_L311_F1.2801.00
111_G226_F1.2771.00
210_L214_I1.2651.00
243_L307_F1.2591.00
294_Q335_T1.2571.00
313_L325_T1.2551.00
422_Y427_S1.2541.00
234_G324_A1.2541.00
108_G137_L1.2531.00
340_L428_F1.2501.00
128_R211_F1.2431.00
204_R209_P1.2431.00
199_C217_G1.2401.00
383_S390_I1.2391.00
413_F431_V1.2361.00
414_I427_S1.2271.00
283_I287_V1.2241.00
216_H228_T1.2141.00
97_L127_P1.2131.00
295_V306_S1.2111.00
103_D119_V1.2111.00
91_L137_L1.2081.00
344_F410_T1.2081.00
122_D230_S1.2061.00
303_L307_F1.2051.00
336_I442_F1.1981.00
345_F361_F1.1971.00
291_T294_Q1.1901.00
84_S105_L1.1881.00
462_I466_L1.1761.00
234_G327_D1.1741.00
126_L134_R1.1721.00
70_R74_I1.1671.00
121_D230_S1.1631.00
328_Y331_W1.1571.00
105_L109_V1.1551.00
100_T454_D1.1541.00
290_V339_L1.1541.00
195_L251_L1.1541.00
410_T414_I1.1521.00
239_Y242_E1.1491.00
431_V463_A1.1471.00
286_G314_A1.1421.00
367_Q400_W1.1411.00
452_L460_M1.1331.00
70_R73_F1.1321.00
135_S214_I1.1311.00
309_H326_Q1.1261.00
237_N242_E1.1241.00
182_A186_R1.1211.00
275_I278_R1.1181.00
242_E246_G1.1161.00
135_S211_F1.1111.00
249_S315_S1.1101.00
309_H313_L1.1021.00
363_I396_M1.1011.00
305_G309_H1.0971.00
328_Y442_F1.0881.00
132_Y136_Q1.0881.00
84_S88_A1.0841.00
340_L429_A1.0821.00
220_T248_F1.0811.00
195_L259_W1.0791.00
292_S295_V1.0751.00
243_L246_G1.0601.00
393_D397_R1.0571.00
279_F362_L1.0551.00
201_V205_L1.0511.00
332_P335_T1.0511.00
286_G294_Q1.0491.00
420_M456_A1.0481.00
71_D74_I1.0471.00
301_Y309_H1.0431.00
349_I359_L1.0401.00
363_I399_V1.0241.00
231_E234_G1.0211.00
287_V291_T1.0211.00
271_L275_I1.0211.00
291_T306_S1.0211.00
258_L274_D1.0151.00
120_I126_L1.0141.00
269_K273_R1.0141.00
284_A318_L1.0131.00
135_S218_I1.0131.00
287_V342_S1.0081.00
292_S296_W1.0071.00
196_G217_G1.0071.00
199_C245_A1.0071.00
254_F277_L1.0071.00
265_R268_I1.0031.00
293_F296_W0.9971.00
239_Y243_L0.9941.00
282_L294_Q0.9921.00
452_L456_A0.9911.00
371_E397_R0.9911.00
453_N456_A0.9901.00
403_F407_T0.9901.00
434_C460_M0.9891.00
87_S108_G0.9851.00
203_Y244_V0.9851.00
288_I292_S0.9841.00
431_V460_M0.9760.99
272_I276_E0.9760.99
209_P213_A0.9730.99
239_Y304_H0.9730.99
417_L431_V0.9730.99
91_L129_A0.9720.99
277_L281_L0.9710.99
409_F466_L0.9690.99
334_H415_L0.9690.99
128_R131_L0.9690.99
281_L362_L0.9690.99
418_N427_S0.9650.99
227_S232_S0.9630.99
287_V314_A0.9620.99
199_C244_V0.9610.99
271_L274_D0.9580.99
291_T310_S0.9580.99
276_E279_F0.9570.99
414_I424_F0.9560.99
250_L284_A0.9520.99
258_L277_L0.9510.99
199_C203_Y0.9510.99
122_D126_L0.9510.99
336_I426_T0.9500.99
274_D387_G0.9490.99
77_V465_I0.9420.99
309_H325_T0.9410.99
273_R276_E0.9330.99
203_Y220_T0.9310.99
111_G134_R0.9260.99
107_E134_R0.9230.99
227_S230_S0.9220.99
233_I241_V0.9210.99
143_L189_W0.9210.99
456_A460_M0.9150.99
132_Y211_F0.9150.99
365_F369_K0.9130.99
93_I98_N0.9130.99
417_L460_M0.9120.99
216_H229_H0.9110.99
93_I99_L0.9080.99
329_A336_I0.9070.99
119_V122_D0.9070.99
237_N301_Y0.9060.99
409_F463_A0.9060.99
420_M455_I0.9060.99
92_W101_F0.9020.99
366_K386_V0.9010.99
228_T236_F0.8980.99
430_T441_G0.8960.99
190_I194_L0.8920.99
199_C220_T0.8900.99
107_E122_D0.8900.99
338_F415_L0.8870.99
124_S230_S0.8840.99
455_I459_L0.8840.99
122_D134_R0.8820.99
224_G320_D0.8810.99
289_I293_F0.8810.99
313_L339_L0.8800.99
343_S438_M0.8800.99
261_I272_I0.8760.99
205_L240_L0.8740.99
251_L259_W0.8730.99
92_W127_P0.8720.99
273_R279_F0.8720.99
250_L283_I0.8700.99
135_S138_N0.8680.99
109_V474_V0.8640.99
290_V294_Q0.8580.99
94_D127_P0.8550.99
279_F358_S0.8510.99
89_F93_I0.8480.99
344_F406_Y0.8450.98
433_A441_G0.8450.98
94_D131_L0.8440.98
329_A442_F0.8420.98
79_F112_I0.8400.98
75_I145_V0.8390.98
333_T425_L0.8380.98
138_N222_S0.8380.98
195_L221_V0.8350.98
373_N382_L0.8340.98
286_G293_F0.8270.98
283_I286_G0.8200.98
166_S180_R0.8190.98
87_S90_P0.8160.98
274_D279_F0.8120.98
287_V294_Q0.8110.98
180_R183_D0.8110.98
278_R281_L0.8100.98
117_A433_A0.8000.98
268_I271_L0.8000.98
135_S219_S0.7960.98
200_I204_R0.7910.98
370_H384_V0.7900.98
405_L472_Y0.7890.98
203_Y233_I0.7890.98
366_K384_V0.7890.98
270_P273_R0.7890.98
368_S405_L0.7890.98
96_E127_P0.7850.98
197_I201_V0.7850.98
238_N242_E0.7830.98
80_W112_I0.7830.98
271_L277_L0.7820.97
435_I463_A0.7810.97
148_L189_W0.7790.97
201_V204_R0.7790.97
101_F458_C0.7790.97
259_W271_L0.7770.97
209_P212_D0.7770.97
349_I358_S0.7750.97
301_Y306_S0.7740.97
288_I311_F0.7730.97
364_L368_S0.7710.97
340_L425_L0.7690.97
314_A342_S0.7690.97
287_V307_F0.7640.97
238_N241_V0.7640.97
301_Y305_G0.7610.97
288_I295_V0.7600.97
272_I275_I0.7570.97
194_L198_A0.7520.97
223_L319_T0.7510.97
246_G250_L0.7500.97
273_R278_R0.7430.97
212_D216_H0.7430.97
209_P236_F0.7420.97
285_L288_I0.7410.97
367_Q396_M0.7390.96
275_I387_G0.7360.96
107_E118_T0.7360.96
368_S401_S0.7350.96
112_I137_L0.7350.96
304_H307_F0.7340.96
215_C219_S0.7300.96
282_L291_T0.7280.96
233_I236_F0.7280.96
272_I278_R0.7280.96
246_G287_V0.7270.96
313_L328_Y0.7250.96
343_S433_A0.7240.96
291_T303_L0.7190.96
471_I475_I0.7180.96
187_T260_Y0.7150.96
337_V424_F0.7150.96
426_T444_A0.7140.96
276_E281_L0.7120.96
278_R348_C0.7120.96
284_A287_V0.7090.96
432_A436_N0.7090.96
83_F137_L0.7080.95
83_F87_S0.7070.95
297_H301_Y0.7070.95
277_L362_L0.7050.95
364_L404_F0.7030.95
283_I358_S0.7030.95
418_N424_F0.6990.95
183_D186_R0.6980.95
427_S444_A0.6970.95
253_A347_G0.6950.95
272_I279_F0.6930.95
288_I294_Q0.6920.95
127_P130_Y0.6910.95
331_W335_T0.6900.95
444_A447_S0.6870.95
117_A434_C0.6860.95
80_W109_V0.6860.95
216_H245_A0.6850.95
85_V105_L0.6850.95
326_Q331_W0.6830.95
138_N218_I0.6820.94
414_I418_N0.6800.94
311_F315_S0.6760.94
102_I460_M0.6760.94
118_T134_R0.6750.94
223_L252_S0.6740.94
303_L306_S0.6740.94
417_L427_S0.6730.94
196_G200_I0.6710.94
106_F119_V0.6700.94
191_T195_L0.6700.94
288_I291_T0.6680.94
324_A327_D0.6670.94
118_T123_V0.6670.94
274_D277_L0.6660.94
300_M306_S0.6630.94
445_T452_L0.6630.94
124_S229_H0.6620.94
286_G290_V0.6600.93
120_I125_S0.6590.93
406_Y436_N0.6580.93
429_A440_L0.6580.93
223_L352_T0.6570.93
240_L243_L0.6550.93
74_I78_M0.6530.93
216_H323_L0.6530.93
289_I292_S0.6510.93
257_T350_G0.6510.93
454_D457_K0.6490.93
370_H393_D0.6490.93
210_L213_A0.6460.93
199_C202_C0.6450.93
457_K461_C0.6430.93
419_G453_N0.6430.93
368_S404_F0.6420.93
68_R73_F0.6410.92
366_K369_K0.6410.92
73_F465_I0.6390.92
254_F259_W0.6370.92
425_L442_F0.6360.92
89_F129_A0.6340.92
410_T428_F0.6340.92
295_V303_L0.6340.92
292_S307_F0.6320.92
93_I125_S0.6320.92
271_L276_E0.6310.92
242_E313_L0.6310.92
138_N323_L0.6310.92
205_L213_A0.6300.92
424_F427_S0.6300.92
441_G446_A0.6280.92
259_W263_I0.6280.92
466_L474_V0.6280.92
234_G237_N0.6270.92
286_G296_W0.6250.92
94_D130_Y0.6240.91
280_F387_G0.6240.91
307_F311_F0.6240.91
333_T336_I0.6230.91
268_I272_I0.6220.91
211_F215_C0.6210.91
104_A108_G0.6190.91
286_G289_I0.6190.91
324_A440_L0.6180.91
313_L316_S0.6180.91
191_T259_W0.6170.91
77_V81_I0.6160.91
85_V101_F0.6150.91
277_L366_K0.6140.91
117_A441_G0.6130.91
67_L74_I0.6120.91
287_V310_S0.6120.91
429_A441_G0.6110.91
207_G211_F0.6110.91
282_L287_V0.6090.90
428_F432_A0.6060.90
422_Y452_L0.6040.90
117_A440_L0.5990.90
337_V414_I0.5990.90
123_V131_L0.5990.90
329_A447_S0.5970.90
232_S438_M0.5960.90
287_V295_V0.5960.90
192_Y222_S0.5960.90
217_G248_F0.5950.89
364_L400_W0.5950.89
223_L321_N0.5940.89
197_I200_I0.5920.89
100_T104_A0.5920.89
234_G325_T0.5910.89
233_I242_E0.5890.89
196_G218_I0.5890.89
410_T431_V0.5880.89
316_S440_L0.5850.89
196_G221_V0.5780.88
258_L278_R0.5750.88
114_T320_D0.5750.88
320_D354_G0.5720.88
80_W113_T0.5720.88
89_F92_W0.5720.88
212_D228_T0.5690.87
77_V474_V0.5690.87
275_I362_L0.5680.87
356_I403_F0.5680.87
430_T440_L0.5680.87
312_F323_L0.5680.87
371_E401_S0.5670.87
408_L412_F0.5650.87
262_V271_L0.5650.87
288_I296_W0.5650.87
156_L159_G0.5640.87
381_L385_N0.5630.87
88_A98_N0.5630.87
195_L252_S0.5620.87
255_N276_E0.5620.87
290_V334_H0.5600.86
314_A339_L0.5600.86
337_V341_L0.5590.86
114_T223_L0.5580.86
283_I318_L0.5580.86
118_T219_S0.5570.86
347_G358_S0.5560.86
270_P276_E0.5550.86
435_I471_I0.5540.86
117_A445_T0.5530.86
318_L342_S0.5520.86
430_T460_M0.5510.86
84_S108_G0.5500.85
143_L188_L0.5500.85
206_A236_F0.5490.85
184_T351_S0.5480.85
282_L295_V0.5460.85
430_T433_A0.5460.85
132_Y135_S0.5450.85
429_A433_A0.5450.85
283_I345_F0.5450.85
272_I277_L0.5440.85
320_D323_L0.5440.85
113_T354_G0.5440.85
81_I84_S0.5430.85
313_L331_W0.5420.85
340_L344_F0.5420.85
298_I301_Y0.5410.85
427_S431_V0.5400.84
352_T357_K0.5400.84
145_V185_S0.5380.84
194_L197_I0.5370.84
98_N119_V0.5360.84
393_D396_M0.5350.84
287_V311_F0.5340.84
409_F435_I0.5340.84
178_T184_T0.5330.84
232_S236_F0.5330.84
75_I79_F0.5330.84
340_L442_F0.5320.84
422_Y426_T0.5310.83
233_I312_F0.5300.83
78_M82_L0.5300.83
99_L103_D0.5300.83
454_D458_C0.5290.83
218_I222_S0.5280.83
443_G447_S0.5280.83
96_E99_L0.5280.83
177_L184_T0.5270.83
316_S321_N0.5270.83
120_I123_V0.5270.83
343_S436_N0.5260.83
409_F413_F0.5250.83
254_F280_F0.5250.83
100_T457_K0.5240.83
372_I479_S0.5240.83
341_L411_V0.5230.82
203_Y323_L0.5220.82
76_I80_W0.5210.82
249_S314_A0.5200.82
117_A430_T0.5200.82
230_S234_G0.5190.82
267_T270_P0.5190.82
324_A328_Y0.5170.82
269_K274_D0.5170.82
189_W193_S0.5170.82
215_C221_V0.5160.82
269_K272_I0.5160.82
85_V88_A0.5160.82
205_L209_P0.5150.82
161_A182_A0.5140.81
334_H419_G0.5140.81
320_D435_I0.5140.81
192_Y196_G0.5130.81
139_F218_I0.5120.81
283_I294_Q0.5120.81
406_Y410_T0.5110.81
153_L477_L0.5090.81
277_L280_F0.5080.81
219_S438_M0.5080.81
284_A295_V0.5070.81
286_G295_V0.5060.80
146_I452_L0.5060.80
125_S128_R0.5050.80
169_P181_L0.5040.80
405_L409_F0.5040.80
230_S235_Y0.5020.80
363_I367_Q0.5020.80
120_I134_R0.5020.80
119_V457_K0.5020.80
419_G456_A0.5010.80
400_W404_F0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.9588 100 0.087 Contact Map
4j7cI 2 0.8206 100 0.307 Contact Map
3ukmA 2 0.4701 93 0.953 Contact Map
4bw5A 2 0.4866 91.3 0.955 Contact Map
3vouA 4 0.268 82.7 0.961 Contact Map
4twkA 2 0.4845 81.3 0.961 Contact Map
2a9hA 4 0.1794 79.4 0.962 Contact Map
1lnqA 6 0.1629 78.8 0.962 Contact Map
2ih3C 4 0.1773 77.4 0.963 Contact Map
2q67A 3 0.2144 76.6 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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