DPPA - ECOLI - GREMLIN Contacts

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DPPA - Periplasmic dipeptide transport protein

UniProt:	P23847	Sequences: MRISLKKSGMLKLGLSLVAMTVAASVQAKTLVYCSEGSPEGFNPQLFTSGTTYDASSVPLYNRLVEFKIGTTEVIPGLAEKWEVSEDGKTYTFHLRKGVKWHDNKEFKPTRELNADDVVFSFDRQKNAQNPYHKVSGGSYEYFEGMGLPELISEVKKVDDNTVQFVLTRPEAPFLADLAMDFASILSKEYADAMMKAGTPEKLDLNPIGTGPFQLQQYQKDSRIRYKAFDGYWGTKPQIDTLVFSITPDASVRYAKLQKNECQVMPYPNPADIARMKQDKSINLMEMPGLNVGYLSYNVQKKPLDDVKVRQALTYAVNKDAIIKAVYQGAGVSAKNLIPPTMWGYNDDVQDYTYDPEKAKALLKEAGLEKGFSIDLWAMPVQRPYNPNARRMAEMIQADWAKVGVQAKIVTYEWGEYLKRAKDGEHQTVMMGWTGDNGDPDNFFATLFSCAASEQGSNYSKWCYKPFEDLIQPARATDDHNKRVELYKQAQVVMHDQAPALIIAHSTVFEPVRKEVKGYVVDPLGKHHFENVSIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10248
Length:	535 (484)
Sequences:	22905 (17296)
Seq/√Len:	786.2

ECOLI - DPPA SAPA DDPA YGIS GSIB OPPA MPPA NIKA YEJA YBAE SGRR
BACSU - APPA OPPA DPPE YHJP
HALSA - Q9HMI3 Q9HMW4
SULSO - Q97VF7 Q97VK5 Q97UG7 Q97UH5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
216_Q	227_K	4.197	1.00
156_K	164_Q	3.227	1.00
158_V	164_Q	3.217	1.00
308_K	365_E	3.174	1.00
358_K	361_A	3.102	1.00
97_K	161_N	3.090	1.00
119_V	123_D	2.902	1.00
159_D	162_T	2.885	1.00
469_D	473_P	2.873	1.00
320_D	324_K	2.805	1.00
214_Q	227_K	2.750	1.00
450_C	463_C	2.712	1.00
477_T	482_K	2.684	1.00
302_K	305_D	2.636	1.00
119_V	157_K	2.625	1.00
315_Y	358_K	2.518	1.00
361_A	365_E	2.458	1.00
81_K	94_H	2.450	1.00
318_N	321_A	2.450	1.00
30_T	241_T	2.403	1.00
313_L	400_W	2.361	1.00
83_E	94_H	2.347	1.00
156_K	166_V	2.328	1.00
68_K	73_E	2.321	1.00
90_T	164_Q	2.311	1.00
373_S	406_Q	2.304	1.00
375_D	408_K	2.295	1.00
188_K	192_D	2.287	1.00
113_L	210_T	2.282	1.00
450_C	468_E	2.246	1.00
116_D	157_K	2.238	1.00
307_V	311_Q	2.206	1.00
466_P	469_D	2.205	1.00
68_K	75_I	2.201	1.00
92_T	164_Q	2.200	1.00
65_V	82_W	2.168	1.00
462_W	497_Q	2.156	1.00
100_K	112_E	2.139	1.00
308_K	311_Q	2.137	1.00
225_R	241_T	2.127	1.00
105_K	189_E	2.126	1.00
401_A	406_Q	2.125	1.00
482_K	485_E	2.118	1.00
102_H	229_F	2.110	1.00
308_K	362_L	2.107	1.00
100_K	231_G	2.061	1.00
473_P	486_L	2.050	1.00
90_T	166_V	2.049	1.00
85_S	89_K	2.009	1.00
464_Y	493_V	2.000	1.00
62_N	77_G	1.986	1.00
153_S	168_T	1.959	1.00
256_K	261_E	1.957	1.00
479_D	482_K	1.956	1.00
377_W	410_V	1.949	1.00
116_D	188_K	1.948	1.00
94_H	162_T	1.929	1.00
301_K	427_Q	1.925	1.00
99_V	113_L	1.917	1.00
30_T	243_V	1.909	1.00
84_V	91_Y	1.903	1.00
464_Y	497_Q	1.895	1.00
485_E	489_Q	1.893	1.00
375_D	406_Q	1.876	1.00
34_C	262_C	1.839	1.00
68_K	71_T	1.817	1.00
219_Q	222_S	1.812	1.00
122_F	165_F	1.809	1.00
217_Q	225_R	1.793	1.00
467_F	490_A	1.789	1.00
397_Q	401_A	1.777	1.00
80_E	97_K	1.767	1.00
297_Y	501_L	1.757	1.00
217_Q	223_R	1.755	1.00
214_Q	230_D	1.754	1.00
474_A	487_Y	1.751	1.00
307_V	497_Q	1.748	1.00
117_D	188_K	1.748	1.00
420_R	425_E	1.748	1.00
227_K	241_T	1.746	1.00
43_N	124_R	1.741	1.00
316_A	403_V	1.730	1.00
32_V	243_V	1.723	1.00
470_L	489_Q	1.722	1.00
118_V	163_V	1.710	1.00
114_N	117_D	1.704	1.00
492_V	496_D	1.687	1.00
334_A	505_H	1.665	1.00
449_S	472_Q	1.661	1.00
80_E	94_H	1.657	1.00
154_E	166_V	1.650	1.00
466_P	493_V	1.640	1.00
364_K	369_E	1.633	1.00
29_K	240_D	1.631	1.00
216_Q	241_T	1.631	1.00
98_G	112_E	1.618	1.00
223_R	243_V	1.616	1.00
103_D	187_S	1.614	1.00
116_D	160_D	1.609	1.00
466_P	489_Q	1.608	1.00
116_D	119_V	1.598	1.00
474_A	486_L	1.594	1.00
228_A	240_D	1.588	1.00
355_D	358_K	1.581	1.00
311_Q	358_K	1.577	1.00
80_E	96_R	1.554	1.00
85_S	90_T	1.551	1.00
219_Q	223_R	1.546	1.00
114_N	160_D	1.540	1.00
465_K	469_D	1.538	1.00
320_D	333_S	1.528	1.00
297_Y	428_T	1.525	1.00
489_Q	492_V	1.522	1.00
105_K	187_S	1.520	1.00
258_Q	275_R	1.520	1.00
419_K	423_D	1.500	1.00
470_L	486_L	1.494	1.00
413_E	416_E	1.493	1.00
311_Q	498_A	1.487	1.00
317_V	396_I	1.481	1.00
65_V	93_F	1.480	1.00
377_W	408_K	1.478	1.00
300_Q	461_K	1.463	1.00
274_A	277_K	1.461	1.00
486_L	489_Q	1.447	1.00
115_A	157_K	1.446	1.00
390_R	394_E	1.441	1.00
247_T	256_K	1.437	1.00
477_T	486_L	1.435	1.00
484_V	488_K	1.433	1.00
225_R	243_V	1.432	1.00
85_S	92_T	1.422	1.00
92_T	162_T	1.422	1.00
213_F	239_I	1.410	1.00
307_V	496_D	1.407	1.00
283_N	514_K	1.404	1.00
357_E	360_K	1.399	1.00
314_T	498_A	1.396	1.00
62_N	233_W	1.393	1.00
485_E	488_K	1.375	1.00
410_V	420_R	1.373	1.00
463_C	468_E	1.361	1.00
157_K	160_D	1.342	1.00
399_D	402_K	1.338	1.00
82_W	93_F	1.331	1.00
360_K	364_K	1.330	1.00
62_N	210_T	1.323	1.00
100_K	229_F	1.323	1.00
313_L	405_V	1.320	1.00
493_V	497_Q	1.319	1.00
49_S	52_T	1.311	1.00
32_V	245_S	1.306	1.00
473_P	482_K	1.303	1.00
281_S	514_K	1.301	1.00
469_D	472_Q	1.295	1.00
216_Q	225_R	1.292	1.00
482_K	486_L	1.292	1.00
102_H	214_Q	1.289	1.00
32_V	263_Q	1.288	1.00
103_D	189_E	1.288	1.00
119_V	155_V	1.284	1.00
470_L	493_V	1.280	1.00
323_I	333_S	1.276	1.00
187_S	190_Y	1.276	1.00
153_S	166_V	1.273	1.00
112_E	161_N	1.257	1.00
158_V	162_T	1.257	1.00
309_V	363_L	1.256	1.00
473_P	477_T	1.248	1.00
94_H	161_N	1.247	1.00
31_L	264_V	1.238	1.00
165_F	174_F	1.234	1.00
169_R	476_A	1.233	1.00
99_V	210_T	1.225	1.00
301_K	305_D	1.224	1.00
304_L	313_L	1.216	1.00
256_K	262_C	1.208	1.00
398_A	402_K	1.206	1.00
34_C	253_R	1.206	1.00
296_S	429_V	1.199	1.00
395_M	399_D	1.196	1.00
113_L	185_I	1.194	1.00
226_Y	244_F	1.190	1.00
481_N	484_V	1.189	1.00
223_R	245_S	1.188	1.00
439_D	483_R	1.188	1.00
340_P	505_H	1.181	1.00
96_R	99_V	1.175	1.00
123_D	127_N	1.165	1.00
66_E	77_G	1.155	1.00
263_Q	515_E	1.155	1.00
76_P	82_W	1.154	1.00
257_L	511_P	1.152	1.00
414_W	418_L	1.151	1.00
323_I	331_G	1.148	1.00
321_A	399_D	1.142	1.00
327_Y	504_A	1.137	1.00
102_H	231_G	1.137	1.00
263_Q	513_R	1.136	1.00
203_L	207_P	1.135	1.00
362_L	365_E	1.135	1.00
356_P	360_K	1.134	1.00
361_A	364_K	1.128	1.00
155_V	163_V	1.117	1.00
397_Q	409_I	1.117	1.00
400_W	407_A	1.115	1.00
283_N	512_V	1.113	1.00
96_R	233_W	1.108	1.00
285_M	512_V	1.107	1.00
78_L	210_T	1.106	1.00
112_E	160_D	1.103	1.00
91_Y	174_F	1.103	1.00
309_V	366_A	1.101	1.00
121_S	185_I	1.099	1.00
424_G	461_K	1.099	1.00
66_E	75_I	1.095	1.00
258_Q	279_D	1.093	1.00
10_M	13_L	1.091	1.00
307_V	498_A	1.090	1.00
83_E	92_T	1.090	1.00
481_N	485_E	1.089	1.00
462_W	467_F	1.088	1.00
466_P	470_L	1.087	1.00
286_E	507_T	1.085	1.00
274_A	278_Q	1.083	1.00
214_Q	229_F	1.083	1.00
493_V	496_D	1.078	1.00
28_A	240_D	1.070	1.00
118_V	185_I	1.067	1.00
316_A	400_W	1.060	1.00
189_E	193_A	1.058	1.00
470_L	490_A	1.057	1.00
190_Y	208_I	1.055	1.00
93_F	165_F	1.055	1.00
228_A	237_P	1.055	1.00
397_Q	407_A	1.055	1.00
78_L	99_V	1.054	1.00
17_L	20_M	1.047	1.00
311_Q	362_L	1.040	1.00
120_F	188_K	1.038	1.00
102_H	208_I	1.035	1.00
356_P	403_V	1.034	1.00
80_E	161_N	1.030	1.00
332_V	507_T	1.028	1.00
346_N	488_K	1.022	1.00
398_A	401_A	1.019	1.00
470_L	473_P	1.019	1.00
416_E	420_R	1.016	1.00
473_P	489_Q	1.007	1.00
396_I	400_W	1.005	1.00
357_E	361_A	1.000	1.00
472_Q	476_A	0.997	1.00
324_K	329_G	0.996	1.00
174_F	178_L	0.996	1.00
31_L	239_I	0.992	1.00
474_A	490_A	0.985	1.00
123_D	126_K	0.984	1.00
358_K	362_L	0.979	1.00
228_A	235_T	0.976	1.00
78_L	118_V	0.975	1.00
373_S	408_K	0.975	1.00
314_T	319_K	0.974	1.00
94_H	97_K	0.973	1.00
117_D	120_F	0.970	1.00
91_Y	175_L	0.969	1.00
11_L	14_G	0.965	1.00
308_K	366_A	0.965	1.00
297_Y	313_L	0.964	1.00
120_F	191_A	0.963	1.00
227_K	230_D	0.960	1.00
467_F	471_I	0.960	1.00
115_A	158_V	0.958	1.00
116_D	120_F	0.956	1.00
467_F	494_M	0.955	1.00
346_N	492_V	0.954	1.00
277_K	286_E	0.953	1.00
101_W	117_D	0.953	1.00
311_Q	315_Y	0.951	1.00
91_Y	167_L	0.946	1.00
252_V	256_K	0.946	1.00
92_T	158_V	0.945	1.00
441_D	475_R	0.944	1.00
393_A	409_I	0.943	1.00
255_A	258_Q	0.942	1.00
63_R	77_G	0.940	1.00
376_L	407_A	0.940	1.00
445_A	475_R	0.938	1.00
322_I	392_M	0.936	1.00
115_A	163_V	0.935	1.00
421_A	429_V	0.934	1.00
311_Q	496_D	0.932	1.00
55_A	226_Y	0.931	1.00
262_C	265_M	0.926	1.00
321_A	325_A	0.925	1.00
323_I	504_A	0.922	1.00
391_R	394_E	0.920	1.00
276_M	282_I	0.920	1.00
171_E	177_D	0.914	1.00
254_Y	258_Q	0.912	1.00
79_A	93_F	0.910	1.00
31_L	516_V	0.908	1.00
356_P	402_K	0.908	1.00
97_K	112_E	0.907	1.00
38_S	218_Y	0.907	1.00
314_T	501_L	0.906	1.00
462_W	499_P	0.905	1.00
327_Y	331_G	0.905	1.00
62_N	232_Y	0.904	1.00
467_F	493_V	0.902	1.00
480_H	484_V	0.902	1.00
412_Y	420_R	0.900	1.00
65_V	175_L	0.896	1.00
85_S	88_G	0.894	1.00
60_L	226_Y	0.893	1.00
332_V	340_P	0.892	1.00
272_D	275_R	0.891	1.00
167_L	174_F	0.883	1.00
102_H	209_G	0.882	1.00
94_H	159_D	0.879	1.00
15_L	18_V	0.878	1.00
282_I	511_P	0.874	1.00
65_V	79_A	0.874	1.00
318_N	399_D	0.874	1.00
490_A	493_V	0.867	1.00
213_F	237_P	0.864	1.00
13_L	16_S	0.863	1.00
65_V	74_V	0.863	1.00
304_L	376_L	0.860	1.00
273_I	277_K	0.860	1.00
87_D	90_T	0.860	1.00
102_H	215_L	0.859	1.00
27_Q	238_Q	0.858	1.00
279_D	282_I	0.858	1.00
14_G	17_L	0.857	1.00
354_Y	402_K	0.856	1.00
157_K	163_V	0.854	1.00
218_Y	224_I	0.853	1.00
151_L	171_E	0.851	1.00
89_K	153_S	0.849	1.00
473_P	476_A	0.849	1.00
103_D	208_I	0.842	1.00
368_L	372_F	0.842	1.00
89_K	166_V	0.841	1.00
274_A	328_Q	0.837	1.00
63_R	184_S	0.837	1.00
319_K	333_S	0.837	1.00
488_K	492_V	0.837	1.00
254_Y	276_M	0.834	1.00
296_S	460_S	0.832	1.00
471_I	490_A	0.831	1.00
173_P	439_D	0.830	1.00
359_A	403_V	0.822	1.00
378_A	407_A	0.822	1.00
269_N	272_D	0.819	1.00
11_L	15_L	0.817	1.00
247_T	262_C	0.816	1.00
369_E	372_F	0.816	1.00
257_L	265_M	0.814	1.00
315_Y	362_L	0.813	1.00
449_S	471_I	0.813	1.00
228_A	239_I	0.812	1.00
123_D	155_V	0.812	1.00
257_L	282_I	0.811	1.00
105_K	112_E	0.811	1.00
119_V	163_V	0.807	1.00
386_N	389_A	0.804	1.00
315_Y	352_Y	0.801	1.00
78_L	113_L	0.800	1.00
99_V	161_N	0.795	1.00
306_D	368_L	0.795	1.00
93_F	175_L	0.795	1.00
448_F	500_A	0.795	1.00
441_D	445_A	0.792	1.00
61_Y	209_G	0.789	1.00
60_L	215_L	0.789	1.00
441_D	487_Y	0.788	1.00
295_L	396_I	0.787	1.00
489_Q	493_V	0.784	1.00
337_L	502_I	0.784	1.00
84_V	88_G	0.783	1.00
38_S	246_I	0.783	1.00
59_P	226_Y	0.783	1.00
448_F	494_M	0.778	1.00
291_N	434_T	0.777	1.00
26_V	29_K	0.777	1.00
288_P	507_T	0.773	1.00
89_K	169_R	0.772	1.00
228_A	236_K	0.771	1.00
299_V	499_P	0.770	1.00
253_R	265_M	0.766	1.00
12_K	15_L	0.765	1.00
45_Q	124_R	0.763	1.00
316_A	356_P	0.762	1.00
98_G	161_N	0.757	1.00
390_R	411_T	0.756	1.00
312_A	363_L	0.755	1.00
295_L	428_T	0.753	1.00
306_D	366_A	0.753	1.00
215_L	224_I	0.751	1.00
300_Q	424_G	0.751	1.00
276_M	511_P	0.751	1.00
255_A	259_K	0.750	1.00
458_N	461_K	0.748	1.00
151_L	169_R	0.747	1.00
117_D	121_S	0.744	1.00
445_A	449_S	0.743	1.00
99_V	233_W	0.742	1.00
230_D	240_D	0.742	1.00
33_Y	264_V	0.739	1.00
317_V	400_W	0.738	1.00
362_L	366_A	0.738	1.00
152_I	155_V	0.736	1.00
226_Y	242_L	0.727	1.00
416_E	419_K	0.726	1.00
336_N	491_Q	0.726	1.00
315_Y	354_Y	0.725	1.00
29_K	239_I	0.725	1.00
309_V	368_L	0.724	1.00
95_L	113_L	0.724	1.00
449_S	468_E	0.724	1.00
38_S	220_K	0.724	1.00
401_A	405_V	0.724	1.00
412_Y	416_E	0.723	1.00
281_S	513_R	0.721	1.00
465_K	468_E	0.720	1.00
44_P	186_L	0.718	1.00
189_E	192_D	0.716	1.00
394_E	409_I	0.714	1.00
322_I	395_M	0.713	1.00
115_A	119_V	0.713	1.00
25_S	238_Q	0.711	1.00
31_L	242_L	0.711	1.00
317_V	322_I	0.710	1.00
77_G	233_W	0.709	1.00
286_E	509_F	0.708	1.00
286_E	330_A	0.707	1.00
385_Y	390_R	0.706	1.00
265_M	268_P	0.705	1.00
64_L	79_A	0.704	1.00
313_L	428_T	0.704	1.00
245_S	256_K	0.704	1.00
121_S	186_L	0.703	1.00
315_Y	353_T	0.702	1.00
401_A	407_A	0.700	1.00
127_N	130_N	0.700	1.00
368_L	371_G	0.699	1.00
227_K	240_D	0.698	1.00
18_V	21_T	0.698	1.00
47_F	52_T	0.697	1.00
394_E	397_Q	0.697	1.00
297_Y	304_L	0.697	1.00
400_W	428_T	0.696	1.00
93_F	178_L	0.693	1.00
69_I	520_V	0.692	1.00
483_R	487_Y	0.689	1.00
59_P	242_L	0.687	1.00
157_K	164_Q	0.686	1.00
417_Y	429_V	0.682	1.00
45_Q	125_Q	0.682	1.00
264_V	516_V	0.682	1.00
34_C	247_T	0.682	1.00
369_E	373_S	0.680	1.00
363_L	368_L	0.679	1.00
172_A	483_R	0.678	1.00
499_P	502_I	0.677	1.00
293_G	389_A	0.677	1.00
462_W	493_V	0.677	1.00
47_F	56_S	0.677	1.00
82_W	175_L	0.676	1.00
155_V	165_F	0.674	1.00
400_W	403_V	0.673	1.00
313_L	501_L	0.673	1.00
318_N	354_Y	0.673	1.00
187_S	208_I	0.669	1.00
60_L	209_G	0.665	1.00
375_D	410_V	0.664	1.00
89_K	170_P	0.662	1.00
83_E	86_E	0.661	1.00
394_E	398_A	0.660	1.00
151_L	168_T	0.658	1.00
40_E	49_S	0.658	1.00
214_Q	231_G	0.655	1.00
101_W	185_I	0.655	1.00
249_D	252_V	0.655	1.00
450_C	454_E	0.654	1.00
247_T	253_R	0.654	1.00
363_L	403_V	0.653	1.00
512_V	519_Y	0.652	1.00
304_L	374_I	0.651	1.00
203_L	206_N	0.650	1.00
215_L	218_Y	0.649	1.00
61_Y	207_P	0.648	1.00
101_W	113_L	0.648	1.00
480_H	483_R	0.645	1.00
376_L	428_T	0.644	1.00
55_A	224_I	0.644	1.00
280_K	514_K	0.643	1.00
449_S	454_E	0.642	1.00
468_E	472_Q	0.642	1.00
472_Q	475_R	0.641	1.00
224_I	246_I	0.640	1.00
363_L	366_A	0.640	1.00
126_K	168_T	0.638	1.00
67_F	74_V	0.637	1.00
84_V	175_L	0.637	1.00
9_G	12_K	0.637	1.00
122_F	178_L	0.637	1.00
301_K	304_L	0.636	1.00
257_L	513_R	0.635	1.00
114_N	161_N	0.635	1.00
119_V	156_K	0.635	1.00
123_D	154_E	0.634	1.00
346_N	349_V	0.632	1.00
149_P	152_I	0.632	1.00
29_K	238_Q	0.632	1.00
67_F	179_A	0.631	1.00
513_R	516_V	0.629	1.00
101_W	209_G	0.629	1.00
95_L	161_N	0.627	1.00
486_L	490_A	0.627	1.00
93_F	163_V	0.626	1.00
348_D	492_V	0.625	1.00
234_G	237_P	0.625	1.00
378_A	430_M	0.624	1.00
120_F	124_R	0.623	1.00
346_N	491_Q	0.620	1.00
400_W	405_V	0.620	1.00
360_K	403_V	0.620	1.00
322_I	396_I	0.619	1.00
306_D	309_V	0.619	1.00
348_D	488_K	0.619	1.00
120_F	192_D	0.618	1.00
250_A	253_R	0.618	1.00
61_Y	210_T	0.617	1.00
330_A	509_F	0.617	1.00
304_L	309_V	0.616	1.00
379_M	412_Y	0.616	1.00
320_D	323_I	0.616	1.00
202_K	205_L	0.615	1.00
115_A	161_N	0.614	1.00
387_P	391_R	0.613	1.00
378_A	393_A	0.612	1.00
392_M	396_I	0.612	1.00
113_L	161_N	0.609	1.00
213_F	228_A	0.608	1.00
368_L	374_I	0.608	1.00
239_I	516_V	0.605	1.00
343_W	480_H	0.604	1.00
10_M	14_G	0.603	1.00
128_A	131_P	0.603	1.00
396_I	407_A	0.603	1.00
114_N	188_K	0.603	1.00
60_L	207_P	0.602	1.00
28_A	238_Q	0.601	1.00
101_W	189_E	0.600	1.00
293_G	392_M	0.600	1.00
366_A	369_E	0.599	1.00
387_P	390_R	0.599	1.00
300_Q	305_D	0.597	1.00
356_P	363_L	0.596	1.00
294_Y	500_A	0.596	1.00
372_F	405_V	0.595	1.00
101_W	210_T	0.595	1.00
123_D	188_K	0.594	1.00
317_V	501_L	0.594	1.00
74_V	175_L	0.593	1.00
344_G	484_V	0.591	1.00
301_K	425_E	0.589	1.00
169_R	472_Q	0.588	1.00
299_V	460_S	0.587	1.00
414_W	431_M	0.586	1.00
368_L	405_V	0.586	1.00
222_S	245_S	0.586	1.00
363_L	405_V	0.585	1.00
292_V	334_A	0.585	1.00
374_I	405_V	0.582	1.00
279_D	514_K	0.581	1.00
392_M	504_A	0.580	1.00
412_Y	417_Y	0.577	1.00
95_L	99_V	0.577	1.00
205_L	220_K	0.575	1.00
186_L	191_A	0.575	1.00
8_S	11_L	0.574	1.00
316_A	354_Y	0.572	1.00
25_S	28_A	0.572	1.00
299_V	305_D	0.572	1.00
120_F	189_E	0.571	1.00
24_A	27_Q	0.571	1.00
478_D	482_K	0.571	1.00
123_D	157_K	0.570	1.00
82_W	94_H	0.570	1.00
467_F	470_L	0.569	1.00
254_Y	272_D	0.568	1.00
63_R	210_T	0.568	1.00
306_D	367_G	0.567	1.00
61_Y	203_L	0.567	1.00
364_K	368_L	0.566	1.00
105_K	117_D	0.565	1.00
355_D	361_A	0.565	1.00
90_T	156_K	0.565	1.00
464_Y	467_F	0.564	1.00
377_W	427_Q	0.564	1.00
8_S	12_K	0.564	1.00
323_I	327_Y	0.564	1.00
64_L	118_V	0.564	1.00
113_L	121_S	0.561	1.00
103_D	190_Y	0.560	1.00
498_A	501_L	0.560	1.00
437_N	442_N	0.559	1.00
229_F	232_Y	0.559	1.00
283_N	517_K	0.558	1.00
317_V	503_I	0.557	1.00
314_T	352_Y	0.556	1.00
251_S	272_D	0.555	1.00
260_N	513_R	0.555	1.00
313_L	376_L	0.555	1.00
458_N	462_W	0.554	1.00
66_E	234_G	0.554	1.00
257_L	262_C	0.554	1.00
407_A	428_T	0.553	1.00
18_V	22_V	0.553	1.00
295_L	503_I	0.553	1.00
86_E	90_T	0.553	1.00
474_A	483_R	0.552	1.00
374_I	407_A	0.551	1.00
268_P	511_P	0.551	1.00
53_Y	181_D	0.551	1.00
42_F	224_I	0.551	1.00
213_F	241_T	0.551	1.00
35_S	244_F	0.550	1.00
297_Y	314_T	0.550	1.00
32_V	262_C	0.550	1.00
496_D	499_P	0.548	1.00
419_K	422_K	0.547	1.00
148_L	151_L	0.546	1.00
351_D	495_H	0.546	1.00
349_V	492_V	0.545	1.00
187_S	203_L	0.545	1.00
56_S	61_Y	0.545	1.00
245_S	261_E	0.545	1.00
147_G	150_E	0.545	1.00
350_Q	353_T	0.544	1.00
315_Y	359_A	0.543	1.00
268_P	273_I	0.541	1.00
40_E	52_T	0.540	1.00
294_Y	431_M	0.540	1.00
444_F	490_A	0.538	1.00
115_A	159_D	0.538	1.00
9_G	13_L	0.537	1.00
251_S	255_A	0.537	1.00
264_V	512_V	0.536	1.00
30_T	225_R	0.536	1.00
315_Y	355_D	0.536	1.00
8_S	14_G	0.536	1.00
76_P	81_K	0.536	1.00
399_D	403_V	0.536	1.00
320_D	353_T	0.536	1.00
88_G	92_T	0.535	1.00
326_V	395_M	0.535	1.00
414_W	417_Y	0.535	1.00
235_T	238_Q	0.534	1.00
9_G	14_G	0.533	1.00
25_S	29_K	0.531	1.00
14_G	18_V	0.530	1.00
202_K	206_N	0.528	1.00
330_A	507_T	0.528	1.00
207_P	215_L	0.528	1.00
59_P	244_F	0.527	1.00
215_L	226_Y	0.526	1.00
13_L	17_L	0.526	1.00
378_A	411_T	0.525	1.00
13_L	18_V	0.525	1.00
22_V	25_S	0.524	1.00
358_K	365_E	0.524	1.00
354_Y	399_D	0.523	1.00
491_Q	495_H	0.523	1.00
374_I	378_A	0.522	1.00
335_K	351_D	0.522	1.00
49_S	414_W	0.522	1.00
273_I	284_L	0.522	1.00
125_Q	182_F	0.522	1.00
28_A	241_T	0.522	1.00
112_E	117_D	0.521	1.00
181_D	184_S	0.520	1.00
433_W	447_L	0.519	1.00
62_N	234_G	0.519	1.00
309_V	313_L	0.519	1.00
124_R	191_A	0.518	1.00
56_S	60_L	0.518	1.00
417_Y	421_A	0.517	1.00
126_K	152_I	0.517	1.00
277_K	330_A	0.517	1.00
477_T	480_H	0.517	1.00
102_H	210_T	0.515	1.00
303_P	427_Q	0.515	1.00
42_F	218_Y	0.515	1.00
264_V	510_E	0.514	1.00
439_D	442_N	0.513	1.00
88_G	478_D	0.513	1.00
330_A	333_S	0.512	1.00
490_A	494_M	0.512	1.00
95_L	115_A	0.512	1.00
273_I	509_F	0.511	1.00
352_Y	495_H	0.510	1.00
80_E	95_L	0.510	1.00
101_W	187_S	0.510	1.00
101_W	114_N	0.509	1.00
445_A	472_Q	0.509	1.00
256_K	259_K	0.508	1.00
321_A	395_M	0.508	1.00
477_T	483_R	0.508	1.00
71_T	75_I	0.507	1.00
293_G	506_S	0.506	1.00
295_L	501_L	0.506	1.00
115_A	160_D	0.505	1.00
368_L	373_S	0.505	1.00
349_V	495_H	0.504	1.00
113_L	117_D	0.503	1.00
95_L	118_V	0.503	1.00
322_I	503_I	0.503	1.00
288_P	332_V	0.502	1.00
190_Y	203_L	0.502	1.00
16_S	20_M	0.502	1.00
470_L	474_A	0.501	1.00
322_I	326_V	0.500	1.00
113_L	118_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qflA	1	0.9421	100	0.118	Contact Map
3m8uA	1	0.9364	100	0.143	Contact Map
1dpeA	1	0.9364	100	0.144	Contact Map
3tpaA	1	0.9346	100	0.148	Contact Map
3zs6A	1	0.9178	100	0.15	Contact Map
4fajA	1	0.9028	100	0.153	Contact Map
4tozA	1	0.9308	100	0.153	Contact Map
4gl8A	1	0.9103	100	0.155	Contact Map
1xocA	2	0.9084	100	0.158	Contact Map
1jetA	1	0.9327	100	0.164	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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