GREMLIN Database
CYSN - Sulfate adenylyltransferase subunit 1
UniProt: P23845 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10194
Length: 475 (379)
Sequences: 9621 (4290)
Seq/√Len: 220.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_E301_E4.8401.00
179_T182_R4.6081.00
177_E181_T4.3831.00
294_T297_G3.8581.00
302_A308_I3.8511.00
277_R286_E3.7921.00
291_R298_D3.7791.00
166_A205_L3.3141.00
201_R231_V3.1491.00
246_M272_V3.0361.00
135_I232_L2.9691.00
46_R210_G2.8861.00
271_R301_E2.8751.00
152_S187_Y2.8131.00
288_N313_T2.7561.00
184_R188_L2.5411.00
276_Q326_A2.5351.00
149_R187_Y2.5151.00
274_V300_E2.4611.00
272_V289_V2.4291.00
362_K368_V2.3941.00
388_L394_G2.3901.00
246_M267_L2.3681.00
46_R213_V2.3051.00
279_K327_A2.2991.00
357_I366_A2.2771.00
303_F306_E2.2541.00
135_I166_A2.2141.00
203_V231_V2.2061.00
182_R186_D2.1481.00
436_E439_S2.1411.00
107_R234_T2.1231.00
103_S108_K2.1001.00
272_V310_L2.0781.00
133_L235_V2.0201.00
165_V202_F1.9721.00
355_Y358_K1.9501.00
141_R172_L1.9461.00
167_I204_P1.9461.00
31_L131_C1.9301.00
181_T184_R1.9151.00
181_T204_P1.9151.00
266_T307_A1.9011.00
408_R411_Q1.8851.00
140_A167_I1.8781.00
279_K286_E1.8721.00
274_V298_D1.8671.00
352_G358_K1.8451.00
287_S313_T1.8331.00
155_S163_L1.8231.00
267_L308_I1.8151.00
362_K402_E1.8141.00
247_R269_S1.8031.00
101_Y108_K1.7881.00
273_E276_Q1.7791.00
142_K145_L1.7771.00
274_V292_I1.7721.00
212_N215_S1.7591.00
421_I428_T1.7301.00
176_S182_R1.7161.00
408_R436_E1.7091.00
244_Q269_S1.6951.00
291_R311_V1.6921.00
262_G309_T1.6911.00
277_R288_N1.6861.00
183_I186_D1.6821.00
370_G397_D1.6161.00
263_Y318_I1.6101.00
168_N207_A1.5991.00
181_T193_Q1.5921.00
352_G355_Y1.5911.00
267_L302_A1.5871.00
299_R302_A1.5861.00
33_C155_S1.5791.00
50_D210_G1.5771.00
125_A154_I1.5761.00
241_V244_Q1.5711.00
338_S395_L1.5661.00
278_V289_V1.5551.00
136_L165_V1.5501.00
86_Q90_E1.5411.00
204_P211_D1.5371.00
149_R153_F1.5311.00
170_M211_D1.5171.00
170_M204_P1.5161.00
341_V396_V1.4891.00
175_Y209_E1.4851.00
278_V324_L1.4741.00
179_T183_I1.4511.00
400_F406_L1.4501.00
130_T249_P1.4411.00
283_S316_I1.4271.00
178_E182_R1.4221.00
338_S436_E1.4181.00
25_K107_R1.4181.00
337_A400_F1.4161.00
336_S399_T1.4011.00
278_V287_S1.4001.00
248_F265_G1.3701.00
153_F389_P1.3651.00
279_K330_A1.3631.00
271_R303_F1.3621.00
374_Q392_G1.3531.00
210_G213_V1.3431.00
294_T299_R1.3401.00
372_R397_D1.3381.00
336_S397_D1.3371.00
46_R50_D1.3361.00
341_V344_M1.3351.00
134_A155_S1.3331.00
407_D415_T1.3311.00
52_R55_Y1.3271.00
395_L408_R1.3161.00
292_I310_L1.3121.00
292_I302_A1.3101.00
293_V298_D1.2941.00
349_L355_Y1.2931.00
334_V337_A1.2891.00
43_L228_L1.2881.00
265_G324_L1.2851.00
349_L358_K1.2851.00
336_S340_D1.2831.00
118_E146_D1.2511.00
248_F267_L1.2311.00
47_L229_L1.2251.00
339_V343_W1.2241.00
340_D395_L1.2241.00
419_I422_D1.2131.00
371_I437_P1.2121.00
349_L352_G1.2101.00
338_S397_D1.2071.00
349_L356_D1.2061.00
340_D435_H1.2041.00
164_V232_L1.2021.00
319_S322_D1.1991.00
35_S38_D1.1671.00
310_L324_L1.1641.00
105_E230_E1.1521.00
354_S358_K1.1511.00
339_V418_L1.1491.00
191_A202_F1.1461.00
277_R327_A1.1461.00
280_V324_L1.1421.00
353_Q358_K1.1421.00
96_D364_T1.1381.00
334_V338_S1.1371.00
261_R317_D1.1351.00
354_S357_I1.1231.00
151_H154_I1.1161.00
359_I406_L1.1111.00
413_P430_G1.1101.00
366_A400_F1.1061.00
30_F109_F1.1041.00
38_D142_K1.1031.00
278_V313_T1.0991.00
47_L213_V1.0951.00
254_N309_T1.0931.00
181_T185_E1.0901.00
339_V342_V1.0881.00
152_S163_L1.0871.00
44_I111_I1.0851.00
280_V287_S1.0841.00
133_L164_V1.0831.00
348_P355_Y1.0821.00
340_D343_W1.0821.00
285_V317_D1.0761.00
359_I404_L1.0751.00
138_I165_V1.0711.00
135_I228_L1.0651.00
341_V430_G1.0611.00
353_Q356_D1.0601.00
184_R202_F1.0591.00
359_I362_K1.0571.00
51_T229_L1.0571.00
348_P358_K1.0531.00
349_L357_I1.0531.00
351_P358_K1.0491.00
272_V302_A1.0471.00
356_D363_K1.0471.00
418_L432_G1.0401.00
185_E194_L1.0301.00
164_V231_V1.0251.00
43_L207_A1.0241.00
167_I180_F1.0071.00
357_I420_F1.0051.00
206_S209_E1.0031.00
192_G201_R0.9991.00
43_L137_L0.9981.00
329_E332_P0.9971.00
163_L189_T0.9961.00
164_V203_V0.9951.00
37_D93_I0.9901.00
406_L434_V0.9881.00
249_P268_A0.9881.00
103_S106_K0.9861.00
352_G356_D0.9851.00
184_R187_Y0.9761.00
246_M326_A0.9751.00
299_R306_E0.9741.00
255_R261_R0.9721.00
256_P262_G0.9681.00
230_E233_E0.9671.00
418_L422_D0.9671.00
37_D94_T0.9661.00
366_A370_G0.9651.00
176_S179_T0.9651.00
31_L114_T0.9651.00
283_S322_D0.9631.00
104_T107_R0.9581.00
101_Y306_E0.9561.00
191_A194_L0.9561.00
419_I423_R0.9541.00
335_Q403_P0.9461.00
246_M289_V0.9421.00
153_F375_V0.9391.00
43_L213_V0.9381.00
371_I385_V0.9381.00
372_R376_D0.9351.00
290_A313_T0.9260.99
337_A398_L0.9240.99
242_D271_R0.9220.99
334_V437_P0.9180.99
205_L212_N0.9170.99
248_F310_L0.9150.99
281_L325_L0.9140.99
186_D189_T0.9140.99
369_D399_T0.9130.99
348_P351_P0.9120.99
326_A329_E0.9100.99
209_E212_N0.9090.99
293_V311_V0.9090.99
191_A200_I0.9070.99
348_P387_N0.9040.99
84_G98_A0.9020.99
349_L353_Q0.9000.99
302_A306_E0.8970.99
372_R390_L0.8950.99
338_S435_H0.8910.99
408_R430_G0.8890.99
22_Q243_A0.8880.99
242_D245_P0.8870.99
43_L166_A0.8860.99
205_L209_E0.8780.99
101_Y110_I0.8760.99
348_P353_Q0.8750.99
355_Y366_A0.8740.99
136_L152_S0.8690.99
254_N264_A0.8660.99
290_A311_V0.8650.99
195_P198_L0.8610.99
143_G183_I0.8580.99
180_F184_R0.8500.99
420_F430_G0.8490.99
246_M278_V0.8490.99
42_T207_A0.8460.99
407_D437_P0.8420.99
350_S353_Q0.8420.99
144_V148_T0.8400.99
273_E300_E0.8380.99
416_G419_I0.8350.99
263_Y312_L0.8350.99
167_I202_F0.8350.99
109_F232_L0.8330.99
274_V291_R0.8280.99
389_P392_G0.8250.99
382_Q386_E0.8170.99
140_A143_G0.8140.99
336_S369_D0.8100.99
367_R370_G0.8100.99
349_L354_S0.8080.99
350_S355_Y0.8070.99
185_E190_F0.7970.98
205_L213_V0.7960.98
335_Q339_V0.7940.98
287_S312_L0.7930.98
325_L331_L0.7910.98
32_T135_I0.7890.98
180_F183_I0.7880.98
360_A368_V0.7860.98
187_Y191_A0.7840.98
161_K198_L0.7840.98
432_G436_E0.7830.98
338_S341_V0.7800.98
183_I187_Y0.7790.98
350_S354_S0.7770.98
165_V187_Y0.7770.98
112_A122_R0.7760.98
376_D381_T0.7760.98
242_D303_F0.7760.98
205_L228_L0.7750.98
296_D309_T0.7740.98
185_E189_T0.7680.98
153_F156_T0.7650.98
339_V396_V0.7650.98
248_F272_V0.7610.98
31_L134_A0.7570.98
333_A336_S0.7560.98
373_Y382_Q0.7550.98
362_K366_A0.7550.98
83_D88_E0.7550.98
88_E92_G0.7540.98
350_S356_D0.7530.98
91_Q119_Q0.7520.98
420_F424_L0.7510.98
366_A398_L0.7500.98
248_F324_L0.7490.98
347_Q353_Q0.7480.98
171_D206_S0.7460.98
348_P352_G0.7430.98
361_G366_A0.7400.98
49_H53_Q0.7400.98
124_M128_A0.7380.97
156_T188_L0.7360.97
139_D144_V0.7350.97
24_H243_A0.7350.97
246_M324_L0.7330.97
25_K103_S0.7320.97
24_H242_D0.7310.97
267_L272_V0.7300.97
22_Q241_V0.7290.97
177_E204_P0.7290.97
415_T418_L0.7260.97
37_D117_H0.7220.97
359_I363_K0.7220.97
327_A330_A0.7210.97
36_V93_I0.7200.97
247_R325_L0.7150.97
272_V292_I0.7120.97
258_L262_G0.7120.97
104_T229_L0.7120.97
334_V340_D0.7120.97
102_F109_F0.7070.97
335_Q399_T0.7060.97
231_V235_V0.7050.97
189_T192_G0.7040.97
187_Y190_F0.7040.97
229_L232_L0.7020.97
353_Q357_I0.7010.97
173_V179_T0.6970.96
260_F293_V0.6940.96
189_T200_I0.6940.96
334_V406_L0.6910.96
352_G357_I0.6860.96
30_F232_L0.6840.96
368_V398_L0.6840.96
357_I400_F0.6810.96
373_Y376_D0.6810.96
357_I364_T0.6790.96
302_A307_A0.6790.96
363_K367_R0.6770.96
372_R387_N0.6770.96
33_C134_A0.6770.96
204_P212_N0.6720.96
357_I404_L0.6720.96
102_F111_I0.6710.96
149_R152_S0.6710.96
112_A127_G0.6710.96
208_L211_D0.6650.95
93_I117_H0.6640.95
268_A305_G0.6620.95
332_P437_P0.6620.95
51_T214_A0.6620.95
137_L205_L0.6610.95
251_Q264_A0.6610.95
32_T44_I0.6610.95
36_V94_T0.6550.95
51_T54_I0.6540.95
182_R185_E0.6520.95
400_F404_L0.6500.95
417_G421_I0.6500.95
46_R209_E0.6480.95
338_S372_R0.6480.95
367_R399_T0.6470.95
293_V309_T0.6470.95
51_T55_Y0.6460.95
250_V263_Y0.6440.95
282_P341_V0.6420.94
345_A427_V0.6420.94
372_R395_L0.6410.94
85_L96_D0.6400.94
166_A228_L0.6380.94
153_F157_L0.6380.94
248_F308_I0.6360.94
286_E327_A0.6350.94
412_N415_T0.6340.94
246_M276_Q0.6340.94
35_S145_L0.6330.94
89_R92_G0.6320.94
37_D92_G0.6320.94
207_A210_G0.6320.94
231_V234_T0.6300.94
333_A340_D0.6290.94
245_P326_A0.6290.94
188_L202_F0.6290.94
363_K366_A0.6270.94
420_F423_R0.6260.94
337_A406_L0.6240.94
36_V117_H0.6230.94
203_V212_N0.6230.94
118_E377_I0.6200.93
141_R144_V0.6180.93
400_F428_T0.6180.93
361_G370_G0.6180.93
378_N382_Q0.6170.93
112_A131_C0.6170.93
337_A341_V0.6160.93
373_Y395_L0.6120.93
376_D379_N0.6120.93
44_I112_A0.6110.93
280_V283_S0.6100.93
46_R49_H0.6100.93
30_F111_I0.6090.93
324_L327_A0.6090.93
359_I366_A0.6090.93
245_P329_E0.6080.93
88_E91_Q0.6070.93
178_E181_T0.6060.93
181_T202_F0.6050.93
333_A337_A0.6040.92
184_R204_P0.6040.92
260_F311_V0.6030.92
269_S412_N0.6030.92
124_M151_H0.6020.92
83_D89_R0.5990.92
35_S120_Y0.5970.92
185_E191_A0.5960.92
356_D359_I0.5940.92
357_I398_L0.5930.92
187_Y202_F0.5930.92
214_A229_L0.5930.92
27_L110_I0.5910.92
44_I114_T0.5910.92
252_Y264_A0.5900.92
265_G310_L0.5900.92
109_F233_E0.5900.92
42_T46_R0.5890.92
90_E432_G0.5880.91
296_D299_R0.5860.91
259_D311_V0.5860.91
183_I190_F0.5850.91
343_W430_G0.5850.91
365_R423_R0.5850.91
255_R317_D0.5830.91
43_L205_L0.5820.91
360_A363_K0.5800.91
122_R373_Y0.5790.91
204_P215_S0.5780.91
204_P210_G0.5750.91
409_Y416_G0.5750.91
96_D123_N0.5740.90
388_L391_N0.5730.90
415_T430_G0.5730.90
241_V269_S0.5730.90
342_V346_E0.5730.90
134_A160_I0.5730.90
263_Y315_E0.5720.90
247_R323_L0.5710.90
188_L198_L0.5700.90
348_P354_S0.5700.90
267_L303_F0.5690.90
215_S229_L0.5690.90
274_V290_A0.5660.90
323_L343_W0.5660.90
269_S407_D0.5660.90
97_V112_A0.5650.90
32_T157_L0.5650.90
94_T117_H0.5640.90
348_P357_I0.5630.90
337_A342_V0.5630.90
414_V417_G0.5620.90
358_K363_K0.5620.90
336_S438_V0.5610.89
351_P355_Y0.5610.89
374_Q377_I0.5600.89
96_D100_R0.5590.89
136_L187_Y0.5570.89
149_R190_F0.5560.89
418_L430_G0.5550.89
335_Q341_V0.5540.89
375_V380_L0.5540.89
335_Q338_S0.5530.89
185_E188_L0.5520.89
336_S343_W0.5510.89
108_K306_E0.5510.89
354_S367_R0.5510.89
83_D91_Q0.5500.89
289_V292_I0.5500.89
170_M177_E0.5490.88
38_D145_L0.5490.88
245_P328_D0.5490.88
341_V420_F0.5480.88
52_R56_E0.5480.88
183_I189_T0.5480.88
323_L405_V0.5480.88
41_S45_G0.5480.88
373_Y377_I0.5480.88
280_V313_T0.5470.88
261_R265_G0.5460.88
163_L196_G0.5450.88
121_T125_A0.5440.88
394_G412_N0.5430.88
47_L102_F0.5420.88
211_D215_S0.5410.88
393_I399_T0.5410.88
246_M271_R0.5410.88
367_R371_I0.5400.88
165_V191_A0.5390.88
386_E389_P0.5390.88
374_Q438_V0.5390.88
350_S357_I0.5390.88
360_A372_R0.5390.88
154_I158_L0.5380.87
351_P356_D0.5380.87
137_L203_V0.5380.87
250_V318_I0.5380.87
348_P356_D0.5380.87
355_Y429_V0.5370.87
360_A366_A0.5370.87
143_G146_D0.5360.87
82_V86_Q0.5360.87
170_M212_N0.5360.87
38_D41_S0.5330.87
134_A151_H0.5330.87
21_A24_H0.5320.87
310_L313_T0.5320.87
141_R145_L0.5320.87
272_V278_V0.5310.87
416_G432_G0.5310.87
334_V341_V0.5300.87
360_A405_V0.5290.87
283_S315_E0.5290.87
350_S387_N0.5280.86
159_G163_L0.5280.86
175_Y180_F0.5260.86
279_K284_G0.5260.86
53_Q56_E0.5260.86
349_L368_V0.5250.86
336_S341_V0.5240.86
338_S342_V0.5240.86
376_D380_L0.5240.86
286_E328_D0.5230.86
109_F133_L0.5230.86
205_L208_L0.5210.86
31_L161_K0.5210.86
134_A158_L0.5180.85
405_V408_R0.5160.85
343_W346_E0.5160.85
87_A91_Q0.5140.85
42_T54_I0.5130.85
379_N382_Q0.5120.85
262_G311_V0.5120.85
279_K325_L0.5110.85
256_P259_D0.5110.85
267_L304_A0.5110.85
351_P371_I0.5090.84
250_V324_L0.5080.84
135_I164_V0.5080.84
388_L392_G0.5080.84
369_D372_R0.5070.84
328_D332_P0.5070.84
186_D208_L0.5060.84
43_L135_I0.5040.84
34_G39_G0.5040.84
106_K233_E0.5030.84
414_V430_G0.5030.84
422_D425_S0.5020.84
147_Q150_R0.5010.83
34_G40_K0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f60A 1 0.8716 100 0.291 Contact Map
4d61i 1 0.8632 100 0.294 Contact Map
1jnyA 1 0.8442 100 0.297 Contact Map
4crnP 1 0.8653 100 0.297 Contact Map
1zunB 1 0.8253 100 0.305 Contact Map
1r5bA 1 0.8126 100 0.307 Contact Map
3wy9A 1 0.8463 100 0.309 Contact Map
3mcaA 1 0.7495 100 0.314 Contact Map
3p26A 1 0.8632 100 0.318 Contact Map
3izq1 1 0.8737 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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