OPPA - ECOLI - GREMLIN Contacts

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OPPA - Periplasmic oligopeptide-binding protein

UniProt:	P23843	Sequences: MTNITKRSLVAAGVLAALMAGNVALAADVPAGVTLAEKQTLVRNNGSEVQSLDPHKIEGVPESNISRDLFEGLLVSDLDGHPAPGVAESWDNKDAKVWTFHLRKDAKWSDGTPVTAQDFVYSWQRSVDPNTASPYASYLQYGHIAGIDEILEGKKPITDLGVKAIDDHTLEVTLSEPVPYFYKLLVHPSTSPVPKAAIEKFGEKWTQPGNIVTNGAYTLKDWVVNERIVLERSPTYWNNAKTVINQVTYLPIASEVTDVNRYRSGEIDMTNNSMPIELFQKLKKEIPDEVHVDPYLCTYYYEINNQKPPFNDVRVRTALKLGMDRDIIVNKVKAQGNMPAYGYTPPYTDGAKLTQPEWFGWSQEKRNEEAKKLLAEAGYTADKPLTINLLYNTSDLHKKLAIAASSLWKKNIGVNVKLVNQEWKTFLDTRHQGTFDVARAGWCADYNEPTSFLNTMLSNSSMNTAHYKSPAFDSIMAETLKVTDEAQRTALYTKAEQQLDKDSAIVPVYYYVNARLVKPWVGGYTGKDPLDNTYTRNMYIVKH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10674
Length:	543 (487)
Sequences:	23017 (17456)
Seq/√Len:	791.0

ECOLI - OPPA MPPA YGIS DPPA GSIB SAPA DDPA NIKA YEJA YBAE SGRR
BACSU - DPPE OPPA APPA YHJP
HALSA - Q9HMW4 Q9HMI3
SULSO - Q97VK5 Q97VF7 Q97UG7 Q97UH5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_K	231_E	4.094	1.00
163_K	171_E	3.260	1.00
165_I	171_E	3.218	1.00
314_R	376_E	3.217	1.00
369_E	372_K	3.141	1.00
166_D	169_T	2.995	1.00
326_D	330_N	2.993	1.00
120_V	124_Q	2.928	1.00
474_S	478_E	2.852	1.00
482_V	487_Q	2.828	1.00
104_K	168_H	2.815	1.00
218_T	231_E	2.765	1.00
120_V	164_A	2.667	1.00
308_P	311_N	2.548	1.00
386_T	415_N	2.542	1.00
319_L	408_W	2.493	1.00
321_L	369_E	2.489	1.00
324_D	327_I	2.483	1.00
386_T	417_K	2.439	1.00
195_K	199_E	2.436	1.00
372_K	376_E	2.423	1.00
89_S	101_H	2.395	1.00
91_D	101_H	2.374	1.00
114_V	214_N	2.364	1.00
117_Q	164_A	2.354	1.00
467_Y	502_D	2.341	1.00
471_A	474_S	2.329	1.00
40_T	246_Q	2.328	1.00
77_D	81_H	2.294	1.00
163_K	173_T	2.237	1.00
74_L	90_W	2.214	1.00
97_V	171_E	2.210	1.00
313_V	317_T	2.176	1.00
314_R	373_L	2.174	1.00
112_T	196_A	2.166	1.00
109_S	233_S	2.166	1.00
388_N	419_V	2.166	1.00
314_R	317_T	2.164	1.00
92_N	96_K	2.147	1.00
99_T	171_E	2.124	1.00
77_D	83_A	2.123	1.00
145_A	175_S	2.111	1.00
107_K	113_P	2.107	1.00
487_Q	490_A	2.105	1.00
469_S	498_Q	2.045	1.00
229_V	246_Q	2.013	1.00
106_A	114_V	2.013	1.00
459_N	468_K	1.988	1.00
478_E	491_L	1.969	1.00
484_D	487_Q	1.966	1.00
107_K	235_T	1.963	1.00
388_N	417_K	1.963	1.00
97_V	173_T	1.946	1.00
469_S	502_D	1.940	1.00
71_E	85_G	1.939	1.00
307_K	436_D	1.938	1.00
40_T	248_T	1.923	1.00
117_Q	195_K	1.895	1.00
101_H	169_T	1.883	1.00
490_A	494_K	1.882	1.00
88_E	104_K	1.879	1.00
118_D	195_K	1.873	1.00
53_D	125_R	1.868	1.00
261_R	266_E	1.855	1.00
123_W	172_V	1.850	1.00
471_A	494_K	1.824	1.00
115_T	118_D	1.822	1.00
119_F	170_L	1.812	1.00
472_F	495_A	1.810	1.00
145_A	173_T	1.800	1.00
44_N	267_I	1.796	1.00
218_T	234_P	1.795	1.00
384_P	415_N	1.762	1.00
223_V	226_E	1.734	1.00
303_I	506_V	1.734	1.00
221_D	229_V	1.726	1.00
479_T	492_Y	1.725	1.00
340_A	510_Y	1.711	1.00
221_D	227_R	1.702	1.00
459_N	473_D	1.692	1.00
231_E	246_Q	1.689	1.00
313_V	502_D	1.673	1.00
497_Q	501_K	1.671	1.00
42_V	248_T	1.657	1.00
322_G	412_I	1.656	1.00
105_D	113_P	1.653	1.00
110_D	194_P	1.652	1.00
475_I	494_K	1.650	1.00
39_Q	245_N	1.636	1.00
410_K	415_N	1.634	1.00
479_T	491_L	1.631	1.00
88_E	101_H	1.630	1.00
145_A	161_G	1.629	1.00
161_G	173_T	1.618	1.00
317_T	369_E	1.609	1.00
471_A	498_Q	1.609	1.00
220_K	246_Q	1.604	1.00
117_Q	167_D	1.601	1.00
429_T	434_T	1.594	1.00
232_R	245_N	1.585	1.00
303_I	437_V	1.582	1.00
470_P	474_S	1.567	1.00
117_Q	120_V	1.562	1.00
227_R	248_T	1.557	1.00
494_K	497_Q	1.544	1.00
112_T	194_P	1.544	1.00
366_R	369_E	1.542	1.00
263_R	281_K	1.536	1.00
88_E	103_R	1.528	1.00
475_I	491_L	1.515	1.00
74_L	100_F	1.514	1.00
115_T	167_D	1.490	1.00
428_D	432_Q	1.489	1.00
326_D	339_P	1.485	1.00
116_A	164_A	1.477	1.00
217_Y	244_I	1.476	1.00
458_S	473_D	1.475	1.00
223_V	227_R	1.474	1.00
323_M	404_A	1.474	1.00
92_N	97_V	1.453	1.00
405_S	410_K	1.447	1.00
422_E	425_T	1.445	1.00
252_I	261_R	1.439	1.00
306_Q	466_H	1.438	1.00
320_K	503_S	1.426	1.00
398_K	402_I	1.424	1.00
468_K	473_D	1.424	1.00
317_T	503_S	1.423	1.00
90_W	100_F	1.422	1.00
280_Q	283_K	1.414	1.00
491_L	494_K	1.403	1.00
59_G	62_E	1.402	1.00
71_E	237_W	1.396	1.00
482_V	491_L	1.389	1.00
287_P	519_P	1.382	1.00
371_K	375_A	1.379	1.00
99_T	169_T	1.373	1.00
448_E	488_R	1.359	1.00
489_T	493_T	1.359	1.00
478_E	487_Q	1.359	1.00
313_V	501_K	1.347	1.00
71_E	214_N	1.342	1.00
229_V	248_T	1.334	1.00
319_L	414_V	1.332	1.00
368_E	371_K	1.326	1.00
107_K	233_S	1.313	1.00
109_S	218_T	1.306	1.00
498_Q	502_D	1.305	1.00
106_A	214_N	1.302	1.00
419_V	429_T	1.300	1.00
329_V	339_P	1.299	1.00
315_V	374_L	1.296	1.00
92_N	99_T	1.294	1.00
352_K	355_Q	1.293	1.00
165_I	169_T	1.292	1.00
113_P	168_H	1.280	1.00
490_A	493_T	1.278	1.00
310_F	319_L	1.274	1.00
407_L	411_N	1.272	1.00
101_H	168_H	1.270	1.00
164_A	167_D	1.269	1.00
194_P	197_A	1.269	1.00
487_Q	491_L	1.267	1.00
307_K	311_N	1.259	1.00
42_V	250_L	1.259	1.00
42_V	268_D	1.256	1.00
120_V	162_V	1.247	1.00
172_V	181_F	1.246	1.00
458_S	468_K	1.241	1.00
474_S	477_A	1.240	1.00
310_F	387_I	1.239	1.00
114_V	192_P	1.232	1.00
110_D	196_A	1.224	1.00
92_N	95_A	1.224	1.00
289_E	519_P	1.221	1.00
44_N	258_D	1.218	1.00
475_I	498_Q	1.209	1.00
41_L	269_M	1.207	1.00
261_R	267_I	1.204	1.00
220_K	229_V	1.203	1.00
478_E	482_V	1.199	1.00
391_Y	418_L	1.197	1.00
262_Y	516_L	1.193	1.00
98_W	181_F	1.193	1.00
230_L	249_Y	1.185	1.00
471_A	475_I	1.180	1.00
302_E	438_A	1.180	1.00
86_V	214_N	1.176	1.00
38_K	245_N	1.172	1.00
329_V	337_N	1.170	1.00
346_P	510_Y	1.166	1.00
391_Y	420_N	1.165	1.00
467_Y	472_F	1.161	1.00
403_A	407_L	1.161	1.00
373_L	376_E	1.159	1.00
103_R	106_A	1.158	1.00
124_Q	128_D	1.157	1.00
176_E	481_K	1.156	1.00
84_P	90_W	1.156	1.00
109_S	235_T	1.144	1.00
122_S	192_P	1.141	1.00
103_R	237_W	1.140	1.00
372_K	375_A	1.139	1.00
315_V	377_A	1.135	1.00
405_S	418_L	1.133	1.00
232_R	242_T	1.133	1.00
268_D	520_W	1.126	1.00
423_W	427_L	1.121	1.00
75_V	83_A	1.121	1.00
375_A	380_T	1.119	1.00
162_V	170_L	1.119	1.00
486_A	489_T	1.117	1.00
268_D	518_K	1.115	1.00
227_R	250_L	1.115	1.00
119_F	192_P	1.112	1.00
263_R	285_E	1.111	1.00
367_N	371_K	1.110	1.00
408_W	416_V	1.098	1.00
22_N	25_L	1.095	1.00
327_I	407_L	1.094	1.00
367_N	412_I	1.086	1.00
317_T	373_L	1.081	1.00
322_G	408_W	1.080	1.00
433_G	466_H	1.075	1.00
218_T	233_S	1.074	1.00
389_L	416_V	1.074	1.00
333_K	509_Y	1.073	1.00
75_V	85_G	1.068	1.00
238_N	241_K	1.061	1.00
406_S	410_K	1.057	1.00
116_A	165_I	1.057	1.00
65_I	230_L	1.056	1.00
313_V	503_S	1.055	1.00
98_W	182_Y	1.053	1.00
91_D	99_T	1.051	1.00
257_T	261_R	1.049	1.00
196_A	200_K	1.046	1.00
292_V	512_V	1.042	1.00
88_E	168_H	1.040	1.00
478_E	494_K	1.040	1.00
289_E	517_V	1.038	1.00
113_P	167_D	1.035	1.00
486_A	490_A	1.034	1.00
143_H	178_V	1.029	1.00
86_V	106_A	1.028	1.00
197_A	212_V	1.027	1.00
100_F	172_V	1.027	1.00
96_K	145_A	1.026	1.00
232_R	239_N	1.024	1.00
18_L	21_G	1.021	1.00
291_H	517_V	1.017	1.00
118_D	121_Y	1.016	1.00
121_Y	195_K	1.012	1.00
101_H	104_K	1.009	1.00
387_I	416_V	1.007	1.00
405_S	416_V	1.003	1.00
321_L	363_Q	1.002	1.00
458_S	477_A	0.999	1.00
109_S	212_V	0.999	1.00
498_Q	501_K	0.993	1.00
314_R	377_A	0.990	1.00
320_K	325_R	0.982	1.00
404_A	408_W	0.981	1.00
475_I	495_A	0.980	1.00
303_I	319_L	0.977	1.00
475_I	478_E	0.976	1.00
41_L	244_I	0.975	1.00
108_W	118_D	0.975	1.00
338_M	512_V	0.974	1.00
98_W	174_L	0.973	1.00
472_F	499_L	0.972	1.00
333_K	337_N	0.971	1.00
231_E	234_P	0.968	1.00
94_D	97_V	0.966	1.00
25_L	28_D	0.963	1.00
328_I	400_L	0.962	1.00
368_E	372_K	0.962	1.00
330_N	335_Q	0.959	1.00
479_T	495_A	0.957	1.00
367_N	411_N	0.956	1.00
280_Q	284_K	0.956	1.00
116_A	170_L	0.954	1.00
232_R	241_K	0.953	1.00
467_Y	504_A	0.947	1.00
17_A	20_A	0.947	1.00
21_G	25_L	0.946	1.00
74_L	182_Y	0.943	1.00
86_V	119_F	0.942	1.00
472_F	476_M	0.941	1.00
387_I	437_V	0.941	1.00
477_A	481_K	0.940	1.00
288_D	516_L	0.937	1.00
401_A	418_L	0.936	1.00
124_Q	127_V	0.936	1.00
267_I	270_T	0.936	1.00
48_E	222_W	0.933	1.00
109_S	219_L	0.928	1.00
406_S	411_N	0.926	1.00
369_E	373_L	0.926	1.00
72_G	85_G	0.923	1.00
174_L	181_F	0.922	1.00
71_E	236_Y	0.921	1.00
109_S	213_T	0.920	1.00
101_H	166_D	0.919	1.00
99_T	165_I	0.915	1.00
352_K	493_T	0.908	1.00
278_L	281_K	0.907	1.00
178_V	184_L	0.905	1.00
260_N	263_R	0.902	1.00
181_F	185_L	0.899	1.00
41_L	521_V	0.898	1.00
450_T	480_L	0.898	1.00
104_K	113_P	0.895	1.00
320_K	506_V	0.894	1.00
365_K	411_N	0.894	1.00
283_K	292_V	0.894	1.00
282_L	288_D	0.893	1.00
457_L	477_A	0.893	1.00
121_Y	198_I	0.892	1.00
317_T	321_L	0.892	1.00
399_K	402_I	0.891	1.00
324_D	407_L	0.891	1.00
117_Q	121_Y	0.890	1.00
327_I	331_K	0.888	1.00
329_V	509_Y	0.886	1.00
379_Y	382_D	0.886	1.00
164_A	170_L	0.886	1.00
317_T	501_K	0.885	1.00
275_P	278_L	0.885	1.00
120_V	170_L	0.883	1.00
495_A	498_Q	0.877	1.00
74_L	82_P	0.874	1.00
430_R	438_A	0.872	1.00
96_K	173_T	0.872	1.00
69_L	230_L	0.869	1.00
472_F	498_Q	0.866	1.00
325_R	339_P	0.864	1.00
74_L	87_A	0.864	1.00
259_V	263_R	0.862	1.00
352_K	497_Q	0.858	1.00
421_Q	429_T	0.850	1.00
252_I	267_I	0.849	1.00
259_V	282_L	0.848	1.00
124_Q	162_V	0.847	1.00
390_L	429_T	0.846	1.00
87_A	100_F	0.845	1.00
279_F	283_K	0.842	1.00
476_M	495_A	0.840	1.00
143_H	176_E	0.839	1.00
338_M	346_P	0.838	1.00
343_Y	507_P	0.837	1.00
485_E	489_T	0.837	1.00
280_Q	334_A	0.837	1.00
19_M	22_N	0.833	1.00
180_Y	448_E	0.830	1.00
262_Y	270_T	0.826	1.00
302_E	465_A	0.825	1.00
100_F	182_Y	0.825	1.00
370_A	412_I	0.824	1.00
222_W	228_I	0.823	1.00
106_A	168_H	0.822	1.00
262_Y	288_D	0.822	1.00
217_Y	242_T	0.822	1.00
18_L	22_N	0.821	1.00
380_T	383_K	0.819	1.00
425_T	428_D	0.816	1.00
72_G	191_S	0.815	1.00
110_D	212_V	0.813	1.00
450_T	454_N	0.808	1.00
48_E	251_P	0.808	1.00
118_D	122_S	0.804	1.00
391_Y	401_A	0.803	1.00
70_F	213_T	0.802	1.00
301_Y	404_A	0.799	1.00
69_L	219_L	0.799	1.00
493_T	497_Q	0.799	1.00
144_I	172_V	0.796	1.00
86_V	114_V	0.792	1.00
322_G	367_N	0.789	1.00
164_A	171_E	0.788	1.00
232_R	244_I	0.784	1.00
450_T	492_Y	0.783	1.00
478_E	481_K	0.781	1.00
425_T	429_T	0.781	1.00
37_E	243_V	0.778	1.00
106_A	237_W	0.776	1.00
21_G	24_A	0.776	1.00
285_E	288_D	0.772	1.00
95_A	99_T	0.771	1.00
68_D	230_L	0.771	1.00
470_P	473_D	0.770	1.00
36_A	39_Q	0.767	1.00
321_L	373_L	0.767	1.00
494_K	498_Q	0.766	1.00
96_K	176_E	0.765	1.00
39_Q	244_I	0.765	1.00
324_D	365_K	0.764	1.00
258_D	270_T	0.763	1.00
390_L	421_Q	0.762	1.00
306_Q	433_G	0.760	1.00
100_F	185_L	0.760	1.00
312_D	379_Y	0.758	1.00
219_L	228_I	0.756	1.00
463_N	466_H	0.756	1.00
297_C	443_C	0.756	1.00
318_A	374_L	0.755	1.00
301_Y	437_V	0.752	1.00
35_L	243_V	0.752	1.00
321_L	365_K	0.752	1.00
260_N	264_S	0.752	1.00
102_L	114_V	0.752	1.00
282_L	516_L	0.751	1.00
467_Y	498_Q	0.747	1.00
454_N	480_L	0.747	1.00
374_L	379_Y	0.746	1.00
294_P	512_V	0.746	1.00
55_H	125_R	0.745	1.00
388_N	436_D	0.743	1.00
408_W	437_V	0.740	1.00
305_N	504_A	0.739	1.00
270_T	274_M	0.739	1.00
323_M	328_I	0.739	1.00
43_R	269_M	0.739	1.00
93_K	99_T	0.738	1.00
402_I	418_L	0.737	1.00
445_D	451_S	0.736	1.00
73_L	87_A	0.735	1.00
373_L	377_A	0.732	1.00
85_G	237_W	0.732	1.00
379_Y	383_K	0.729	1.00
143_H	175_S	0.727	1.00
128_D	131_T	0.726	1.00
312_D	377_A	0.725	1.00
234_P	245_N	0.720	1.00
307_K	310_F	0.718	1.00
269_M	521_V	0.716	1.00
122_S	193_V	0.714	1.00
303_I	310_F	0.713	1.00
231_E	245_N	0.711	1.00
410_K	414_V	0.709	1.00
230_L	247_V	0.706	1.00
315_V	379_Y	0.706	1.00
391_Y	398_K	0.705	1.00
421_Q	425_T	0.705	1.00
299_Y	397_H	0.705	1.00
488_R	492_Y	0.702	1.00
323_M	408_W	0.701	1.00
162_V	172_V	0.699	1.00
114_V	168_H	0.699	1.00
121_Y	199_E	0.698	1.00
408_W	412_I	0.697	1.00
54_P	193_V	0.693	1.00
41_L	247_V	0.691	1.00
116_A	120_V	0.691	1.00
319_L	437_V	0.690	1.00
90_W	182_Y	0.690	1.00
68_D	247_V	0.690	1.00
390_L	419_V	0.690	1.00
398_K	420_N	0.689	1.00
20_A	23_V	0.689	1.00
389_L	401_A	0.688	1.00
108_W	196_A	0.688	1.00
292_V	514_A	0.688	1.00
108_W	114_V	0.686	1.00
39_Q	243_V	0.686	1.00
292_V	336_G	0.685	1.00
69_L	213_T	0.685	1.00
504_A	507_P	0.684	1.00
402_I	405_S	0.684	1.00
351_A	355_Q	0.684	1.00
342_G	496_E	0.683	1.00
328_I	403_A	0.683	1.00
385_L	414_V	0.682	1.00
252_I	258_D	0.682	1.00
454_N	458_S	0.680	1.00
374_L	377_A	0.680	1.00
76_S	82_P	0.675	1.00
491_L	495_A	0.674	1.00
379_Y	385_L	0.674	1.00
44_N	252_I	0.674	1.00
55_H	126_S	0.673	1.00
120_V	163_K	0.673	1.00
108_W	213_T	0.672	1.00
197_A	201_F	0.672	1.00
374_L	378_G	0.670	1.00
38_K	243_V	0.669	1.00
402_I	406_S	0.669	1.00
78_L	525_T	0.669	1.00
319_L	506_V	0.668	1.00
250_L	261_R	0.665	1.00
201_F	204_K	0.665	1.00
374_L	412_I	0.661	1.00
16_A	19_M	0.661	1.00
70_F	211_I	0.660	1.00
194_P	212_V	0.657	1.00
108_W	192_P	0.656	1.00
13_G	16_A	0.655	1.00
105_D	168_H	0.654	1.00
14_V	20_A	0.652	1.00
65_I	228_I	0.652	1.00
349_D	485_E	0.651	1.00
305_N	465_A	0.649	1.00
196_A	199_E	0.648	1.00
321_L	364_E	0.646	1.00
129_P	132_A	0.644	1.00
115_T	195_K	0.644	1.00
218_T	235_T	0.644	1.00
328_I	404_A	0.643	1.00
123_W	185_L	0.643	1.00
14_V	17_A	0.641	1.00
112_T	118_D	0.641	1.00
394_S	398_K	0.640	1.00
390_L	435_F	0.639	1.00
76_S	186_V	0.638	1.00
322_G	365_K	0.637	1.00
410_K	416_V	0.637	1.00
127_V	175_S	0.636	1.00
389_L	439_R	0.636	1.00
238_N	242_T	0.635	1.00
453_L	456_M	0.635	1.00
115_T	168_H	0.634	1.00
404_A	416_V	0.634	1.00
114_V	122_S	0.633	1.00
320_K	363_Q	0.632	1.00
244_I	521_V	0.632	1.00
72_G	214_N	0.632	1.00
319_L	387_I	0.631	1.00
48_E	224_V	0.631	1.00
426_F	438_A	0.629	1.00
102_L	168_H	0.626	1.00
379_Y	414_V	0.625	1.00
110_D	197_A	0.624	1.00
408_W	414_V	0.622	1.00
312_D	315_V	0.621	1.00
307_K	434_T	0.621	1.00
121_Y	125_R	0.620	1.00
124_Q	164_A	0.620	1.00
124_Q	161_G	0.619	1.00
287_P	518_K	0.619	1.00
457_L	499_L	0.617	1.00
423_W	440_A	0.616	1.00
52_L	222_W	0.616	1.00
96_K	177_P	0.616	1.00
50_Q	59_G	0.615	1.00
116_A	168_H	0.615	1.00
392_N	395_D	0.615	1.00
35_L	39_Q	0.614	1.00
350_G	489_T	0.613	1.00
310_F	315_V	0.613	1.00
176_E	477_A	0.612	1.00
473_D	477_A	0.612	1.00
228_I	251_P	0.611	1.00
57_I	66_S	0.610	1.00
382_D	385_L	0.610	1.00
477_A	480_L	0.608	1.00
348_T	351_A	0.608	1.00
219_L	222_W	0.607	1.00
326_D	329_V	0.606	1.00
289_E	522_G	0.604	1.00
485_E	488_R	0.602	1.00
217_Y	246_Q	0.601	1.00
262_Y	518_K	0.601	1.00
346_P	351_A	0.601	1.00
453_L	457_L	0.600	1.00
179_P	488_R	0.600	1.00
88_E	91_D	0.597	1.00
518_K	521_V	0.596	1.00
15_L	18_L	0.596	1.00
254_S	257_T	0.596	1.00
305_N	311_N	0.595	1.00
374_L	414_V	0.594	1.00
400_L	404_A	0.593	1.00
517_V	524_Y	0.591	1.00
108_W	214_N	0.591	1.00
472_F	475_I	0.590	1.00
82_P	182_Y	0.589	1.00
70_F	214_N	0.588	1.00
57_I	62_E	0.588	1.00
312_D	378_G	0.587	1.00
306_Q	311_N	0.587	1.00
352_K	496_E	0.585	1.00
69_L	211_I	0.585	1.00
299_Y	400_L	0.585	1.00
71_E	238_N	0.584	1.00
300_Y	505_I	0.580	1.00
217_Y	232_R	0.580	1.00
100_F	170_L	0.580	1.00
90_W	101_H	0.579	1.00
482_V	488_R	0.578	1.00
59_G	423_W	0.578	1.00
336_G	514_A	0.577	1.00
12_A	15_L	0.575	1.00
116_A	166_D	0.575	1.00
400_L	509_Y	0.575	1.00
102_L	106_A	0.575	1.00
11_A	14_V	0.574	1.00
503_S	506_V	0.574	1.00
501_K	504_A	0.573	1.00
365_K	407_L	0.572	1.00
392_N	397_H	0.571	1.00
74_L	91_D	0.571	1.00
367_N	374_L	0.571	1.00
14_V	18_L	0.570	1.00
17_A	21_G	0.568	1.00
211_I	219_L	0.568	1.00
323_M	508_V	0.567	1.00
226_E	250_L	0.567	1.00
323_M	506_V	0.567	1.00
73_L	119_F	0.567	1.00
63_S	188_P	0.565	1.00
298_T	340_A	0.563	1.00
239_N	243_V	0.562	1.00
97_V	163_K	0.561	1.00
95_A	483_T	0.561	1.00
23_V	26_A	0.561	1.00
15_L	19_M	0.561	1.00
109_S	214_N	0.560	1.00
124_Q	195_K	0.560	1.00
375_A	379_Y	0.560	1.00
479_T	488_R	0.559	1.00
262_Y	267_I	0.557	1.00
301_Y	508_V	0.557	1.00
121_Y	196_A	0.556	1.00
366_R	372_K	0.555	1.00
407_L	412_I	0.555	1.00
201_F	210_N	0.554	1.00
35_L	38_K	0.553	1.00
329_V	333_K	0.551	1.00
164_A	169_T	0.550	1.00
371_K	412_I	0.550	1.00
303_I	320_K	0.550	1.00
404_A	439_R	0.549	1.00
125_R	198_I	0.549	1.00
72_G	100_F	0.548	1.00
50_Q	62_E	0.547	1.00
219_L	230_L	0.547	1.00
328_I	508_V	0.547	1.00
259_V	278_L	0.546	1.00
392_N	426_F	0.546	1.00
315_V	319_L	0.546	1.00
52_L	228_I	0.546	1.00
84_P	89_S	0.545	1.00
75_V	238_N	0.545	1.00
233_S	236_Y	0.545	1.00
11_A	18_L	0.544	1.00
416_V	437_V	0.543	1.00
256_V	260_N	0.543	1.00
22_N	26_A	0.542	1.00
457_L	505_I	0.542	1.00
356_P	362_S	0.541	1.00
45_N	249_Y	0.539	1.00
239_N	242_T	0.539	1.00
321_L	370_A	0.539	1.00
351_A	354_T	0.538	1.00
255_E	258_D	0.538	1.00
16_A	20_A	0.537	1.00
92_N	98_W	0.536	1.00
315_V	385_L	0.536	1.00
42_V	267_I	0.535	1.00
144_I	162_V	0.535	1.00
282_L	285_E	0.534	1.00
353_L	356_P	0.534	1.00
495_A	499_L	0.533	1.00
475_I	479_T	0.533	1.00
421_Q	426_F	0.533	1.00
234_P	241_K	0.533	1.00
88_E	102_L	0.532	1.00
15_L	21_G	0.532	1.00
269_M	517_V	0.532	1.00
380_T	384_P	0.531	1.00
525_T	528_D	0.530	1.00
362_S	500_D	0.530	1.00
428_D	431_H	0.530	1.00
250_L	266_E	0.530	1.00
336_G	339_P	0.530	1.00
321_L	366_R	0.529	1.00
256_V	278_L	0.527	1.00
274_M	516_L	0.527	1.00
116_A	169_T	0.526	1.00
279_F	290_V	0.526	1.00
457_L	476_M	0.526	1.00
309_P	436_D	0.526	1.00
448_E	451_S	0.525	1.00
40_T	229_V	0.525	1.00
108_W	122_S	0.525	1.00
326_D	364_E	0.525	1.00
274_M	282_L	0.523	1.00
281_K	284_K	0.522	1.00
112_T	195_K	0.522	1.00
34_T	37_E	0.522	1.00
286_I	519_P	0.522	1.00
445_D	452_F	0.521	1.00
332_V	403_A	0.521	1.00
301_Y	506_V	0.520	1.00
363_Q	503_S	0.520	1.00
93_K	97_V	0.520	1.00
354_T	497_Q	0.519	1.00
300_Y	440_A	0.519	1.00
374_L	385_L	0.517	1.00
483_T	487_Q	0.517	1.00
427_L	430_R	0.516	1.00
265_G	518_K	0.516	1.00
108_W	194_P	0.515	1.00
74_L	185_L	0.515	1.00
278_L	282_L	0.514	1.00
314_R	372_K	0.514	1.00
193_V	198_I	0.513	1.00
380_T	385_L	0.513	1.00
294_P	338_M	0.513	1.00
304_N	436_D	0.512	1.00
102_L	116_A	0.511	1.00
327_I	403_A	0.511	1.00
38_K	246_Q	0.510	1.00
244_I	247_V	0.510	1.00
442_W	445_D	0.510	1.00
66_S	69_L	0.509	1.00
319_L	412_I	0.507	1.00
469_S	472_F	0.507	1.00
453_L	495_A	0.506	1.00
309_P	385_L	0.506	1.00
198_I	201_F	0.504	1.00
336_G	512_V	0.504	1.00
279_F	514_A	0.504	1.00
121_Y	193_V	0.503	1.00
71_E	106_A	0.503	1.00
465_A	505_I	0.502	1.00
299_Y	511_Y	0.501	1.00
283_K	286_I	0.501	1.00
281_K	285_E	0.501	1.00
458_S	476_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fajA	1	0.9098	100	0.143	Contact Map
3zs6A	1	0.9263	100	0.147	Contact Map
1jetA	1	0.9484	100	0.151	Contact Map
4tozA	1	0.9448	100	0.152	Contact Map
4qflA	1	0.895	100	0.161	Contact Map
4gl8A	1	0.9061	100	0.171	Contact Map
1xocA	2	0.884	100	0.181	Contact Map
4wedA	1	0.8508	100	0.187	Contact Map
3m8uA	1	0.8969	100	0.202	Contact Map
2wolA	1	0.9558	100	0.204	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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