YFEA - ECOLI - GREMLIN Contacts

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YFEA - Uncharacterized protein YfeA

UniProt:	P23842	Sequences: MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFGWRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRYVWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYNMLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIAGYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLISFSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYLIGRPQPLAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11145
Length:	729 (601)
Sequences:	4264 (3676)
Seq/√Len:	149.9

ECOLI - YFEA YFGF YEGE DOSP YLIE GMR CSRD YHJK YLAB YJCC RTN YCGG ADRB
BACSU - YKOW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
722_G	725_Q	5.446	1.00
557_E	599_R	5.285	1.00
324_L	328_T	5.095	1.00
388_Q	391_E	5.057	1.00
514_K	716_L	4.859	1.00
552_D	583_T	4.719	1.00
664_G	668_K	4.670	1.00
631_H	658_D	4.179	1.00
487_K	537_K	4.118	1.00
528_Y	531_G	3.789	1.00
699_V	716_L	3.746	1.00
579_L	589_I	3.525	1.00
596_L	600_Y	3.517	1.00
508_A	562_W	3.501	1.00
702_Q	706_A	3.489	1.00
594_I	633_F	3.424	1.00
553_L	592_R	3.307	1.00
688_K	714_Q	3.263	1.00
513_N	516_G	3.185	1.00
494_T	528_Y	3.119	1.00
505_L	527_K	3.088	1.00
558_S	561_K	3.036	1.00
512_R	721_I	3.020	1.00
353_C	439_A	3.009	1.00
608_I	659_I	2.927	1.00
506_L	554_Q	2.904	1.00
701_T	704_Q	2.873	1.00
315_S	319_N	2.835	1.00
445_D	448_Q	2.808	1.00
653_K	676_D	2.785	1.00
450_T	453_P	2.754	1.00
507_Y	726_P	2.665	1.00
524_A	555_V	2.627	1.00
563_L	602_I	2.625	1.00
567_P	606_A	2.558	1.00
355_L	437_Y	2.541	1.00
488_Q	544_Q	2.443	1.00
705_Q	716_L	2.438	1.00
511_I	518_G	2.387	1.00
566_H	727_L	2.369	1.00
343_A	392_K	2.225	1.00
542_I	551_F	2.217	1.00
340_L	402_L	2.210	1.00
558_S	562_W	2.209	1.00
504_L	524_A	2.169	1.00
581_P	614_E	2.158	1.00
351_S	443_R	2.124	1.00
557_E	600_Y	2.110	1.00
562_W	566_H	2.101	1.00
339_A	343_A	2.097	1.00
527_K	532_I	2.078	1.00
524_A	551_F	2.070	1.00
577_V	607_V	2.060	1.00
705_Q	721_I	2.037	1.00
339_A	392_K	2.033	1.00
705_Q	709_H	2.031	1.00
636_R	658_D	2.020	1.00
353_C	414_L	2.019	1.00
387_M	393_L	2.008	1.00
707_L	711_L	2.000	1.00
364_S	372_R	1.967	1.00
539_L	548_S	1.961	1.00
564_A	568_C	1.960	1.00
375_C	426_I	1.952	1.00
524_A	554_Q	1.952	1.00
627_I	637_I	1.941	1.00
639_I	657_A	1.941	1.00
459_S	463_E	1.930	1.00
705_Q	720_L	1.883	1.00
307_Y	311_I	1.848	1.00
369_L	459_S	1.844	1.00
702_Q	720_L	1.839	1.00
335_P	339_A	1.834	1.00
374_H	377_R	1.826	1.00
696_A	713_V	1.822	1.00
638_A	659_I	1.805	1.00
562_W	727_L	1.797	1.00
378_S	426_I	1.796	1.00
340_L	394_Y	1.786	1.00
344_P	451_L	1.779	1.00
497_T	501_Q	1.767	1.00
491_L	541_L	1.760	1.00
664_G	698_F	1.738	1.00
503_D	528_Y	1.728	1.00
356_R	466_C	1.724	1.00
511_I	659_I	1.723	1.00
354_C	462_A	1.711	1.00
363_M	375_C	1.708	1.00
494_T	530_G	1.706	1.00
398_G	463_E	1.679	1.00
378_S	381_R	1.672	1.00
593_I	630_L	1.660	1.00
511_I	695_V	1.655	1.00
560_L	596_L	1.648	1.00
671_V	703_Q	1.644	1.00
597_F	635_F	1.636	1.00
487_K	530_G	1.634	1.00
589_I	593_I	1.629	1.00
441_W	476_S	1.624	1.00
502_G	558_S	1.617	1.00
343_A	346_Q	1.600	1.00
574_R	636_R	1.599	1.00
414_L	441_W	1.589	1.00
511_I	715_Y	1.584	1.00
308_M	311_I	1.584	1.00
358_D	438_G	1.575	1.00
693_S	714_Q	1.570	1.00
361_E	463_E	1.549	1.00
359_N	492_L	1.545	1.00
415_Q	419_N	1.541	1.00
492_L	496_R	1.538	1.00
719_Y	724_P	1.536	1.00
506_L	555_V	1.536	1.00
557_E	596_L	1.527	1.00
579_L	609_L	1.526	1.00
396_L	402_L	1.524	1.00
306_L	309_V	1.524	1.00
554_Q	558_S	1.517	1.00
381_R	384_L	1.517	1.00
359_N	470_H	1.515	1.00
576_S	608_I	1.495	1.00
356_R	463_E	1.490	1.00
677_A	707_L	1.481	1.00
340_L	344_P	1.477	1.00
696_A	708_L	1.464	1.00
441_W	474_L	1.463	1.00
671_V	677_A	1.462	1.00
365_R	463_E	1.457	1.00
265_L	269_V	1.455	1.00
497_T	503_D	1.454	1.00
307_Y	313_H	1.433	1.00
612_T	641_D	1.432	1.00
505_L	532_I	1.429	1.00
684_T	713_V	1.415	1.00
360_L	466_C	1.402	1.00
229_L	233_P	1.394	1.00
364_S	398_G	1.392	1.00
418_V	439_A	1.383	1.00
448_Q	457_Q	1.383	1.00
357_I	437_Y	1.382	1.00
543_A	548_S	1.380	1.00
533_M	539_L	1.380	1.00
660_I	687_A	1.377	1.00
447_N	476_S	1.369	1.00
357_I	379_I	1.366	1.00
560_L	607_V	1.361	1.00
506_L	559_L	1.360	1.00
311_I	315_S	1.359	1.00
503_D	526_L	1.358	1.00
372_R	399_S	1.352	1.00
315_S	318_L	1.351	1.00
312_Y	315_S	1.350	1.00
374_H	429_N	1.348	1.00
528_Y	533_M	1.338	1.00
185_Y	188_R	1.337	1.00
369_L	463_E	1.337	1.00
361_E	364_S	1.331	1.00
382_T	425_Q	1.330	1.00
387_M	391_E	1.329	1.00
361_E	365_R	1.328	1.00
603_S	606_A	1.327	1.00
316_E	319_N	1.327	1.00
522_I	575_F	1.324	1.00
521_E	578_N	1.320	1.00
472_L	475_D	1.319	1.00
716_L	721_I	1.315	1.00
607_V	635_F	1.312	1.00
170_L	173_F	1.309	1.00
345_E	451_L	1.306	1.00
641_D	697_E	1.303	1.00
364_S	399_S	1.299	1.00
354_C	402_L	1.296	1.00
356_R	399_S	1.288	1.00
688_K	694_V	1.284	1.00
628_E	632_K	1.280	1.00
399_S	466_C	1.278	1.00
671_V	707_L	1.269	1.00
369_L	466_C	1.267	1.00
567_P	603_S	1.261	1.00
436_G	471_V	1.259	1.00
400_E	459_S	1.258	1.00
659_I	695_V	1.251	1.00
706_A	710_K	1.249	1.00
365_R	459_S	1.241	1.00
397_P	459_S	1.235	1.00
457_Q	482_S	1.227	1.00
556_L	596_L	1.222	1.00
627_I	656_Q	1.221	1.00
556_L	577_V	1.220	1.00
312_Y	316_E	1.216	1.00
536_D	540_P	1.215	1.00
597_F	602_I	1.214	1.00
542_I	548_S	1.211	1.00
397_P	463_E	1.210	1.00
375_C	435_M	1.209	1.00
311_I	316_E	1.207	1.00
124_R	127_W	1.187	1.00
465_S	475_D	1.184	1.00
307_Y	310_R	1.183	1.00
314_R	317_W	1.179	1.00
361_E	466_C	1.178	1.00
364_S	466_C	1.173	1.00
507_Y	532_I	1.173	1.00
230_L	234_Y	1.172	1.00
699_V	708_L	1.172	1.00
127_W	130_L	1.170	1.00
414_L	474_L	1.168	1.00
495_I	504_L	1.165	1.00
612_T	645_G	1.165	1.00
543_A	580_M	1.164	1.00
361_E	372_R	1.162	1.00
662_I	683_I	1.156	1.00
496_R	547_L	1.154	1.00
230_L	233_P	1.152	1.00
170_L	174_T	1.146	1.00
378_S	382_T	1.144	1.00
610_E	661_K	1.138	1.00
327_L	342_Q	1.137	1.00
505_L	524_A	1.136	1.00
321_R	325_Q	1.133	1.00
226_L	230_L	1.132	1.00
225_V	229_L	1.130	1.00
595_R	599_R	1.127	0.99
358_D	466_C	1.123	0.99
644_T	666_F	1.121	0.99
681_R	689_A	1.115	0.99
356_R	400_E	1.111	0.99
364_S	373_V	1.111	0.99
494_T	529_D	1.111	0.99
653_K	669_D	1.110	0.99
408_P	413_R	1.107	0.99
682_S	689_A	1.105	0.99
228_L	231_C	1.105	0.99
438_G	469_H	1.101	0.99
225_V	231_C	1.100	0.99
428_W	433_L	1.097	0.99
657_A	692_L	1.094	0.99
468_H	475_D	1.092	0.99
465_S	472_L	1.092	0.99
397_P	400_E	1.090	0.99
360_L	364_S	1.087	0.99
579_L	583_T	1.086	0.99
578_N	610_E	1.085	0.99
523_L	641_D	1.083	0.99
135_G	138_C	1.081	0.99
578_N	661_K	1.076	0.99
590_A	626_N	1.076	0.99
495_I	498_A	1.073	0.99
374_H	378_S	1.067	0.99
681_R	685_D	1.067	0.99
559_L	575_F	1.065	0.99
477_R	482_S	1.064	0.99
308_M	312_Y	1.063	0.99
670_I	707_L	1.063	0.99
670_I	677_A	1.060	0.99
539_L	612_T	1.058	0.99
677_A	681_R	1.057	0.99
339_A	342_Q	1.057	0.99
499_L	551_F	1.056	0.99
642_F	683_I	1.055	0.99
349_G	446_G	1.053	0.99
578_N	640_D	1.047	0.99
427_H	430_N	1.038	0.99
464_Q	467_A	1.037	0.99
478_E	481_V	1.033	0.99
514_K	705_Q	1.031	0.99
356_R	364_S	1.029	0.99
536_D	664_G	1.027	0.99
624_M	628_E	1.021	0.99
130_L	134_I	1.016	0.99
307_Y	312_Y	1.015	0.99
168_D	172_L	1.011	0.99
592_R	596_L	1.010	0.99
591_G	629_Q	1.006	0.99
313_H	316_E	1.005	0.99
608_I	638_A	1.004	0.99
379_I	426_I	1.004	0.99
667_V	680_V	1.003	0.99
444_F	454_L	1.002	0.99
508_A	522_I	1.002	0.99
556_L	593_I	1.000	0.99
226_L	231_C	0.999	0.99
506_L	524_A	0.998	0.99
574_R	608_I	0.998	0.99
311_I	314_R	0.998	0.99
340_L	404_V	0.997	0.99
513_N	714_Q	0.997	0.99
356_R	361_E	0.996	0.99
563_L	567_P	0.994	0.99
719_Y	723_R	0.994	0.99
671_V	704_Q	0.991	0.99
356_R	369_L	0.989	0.99
464_Q	468_H	0.989	0.99
335_P	392_K	0.987	0.99
184_Y	188_R	0.982	0.99
534_T	540_P	0.982	0.99
358_D	470_H	0.978	0.99
331_L	373_V	0.974	0.99
264_N	268_A	0.971	0.98
321_R	324_L	0.970	0.98
228_L	233_P	0.969	0.98
421_L	426_I	0.968	0.98
523_L	697_E	0.968	0.98
359_N	544_Q	0.967	0.98
393_L	403_L	0.962	0.98
193_P	196_A	0.962	0.98
226_L	232_T	0.957	0.98
142_L	146_F	0.951	0.98
612_T	697_E	0.950	0.98
421_L	437_Y	0.949	0.98
518_G	573_P	0.949	0.98
361_E	398_G	0.949	0.98
402_L	455_L	0.949	0.98
560_L	602_I	0.948	0.98
123_Q	127_W	0.945	0.98
545_F	548_S	0.940	0.98
530_G	537_K	0.940	0.98
504_L	554_Q	0.935	0.98
684_T	711_L	0.932	0.98
687_A	694_V	0.931	0.98
142_L	145_S	0.930	0.98
499_L	502_G	0.928	0.98
337_F	373_V	0.922	0.98
521_E	661_K	0.918	0.98
298_L	301_F	0.917	0.98
342_Q	392_K	0.915	0.98
543_A	614_E	0.914	0.98
584_L	615_Q	0.914	0.98
681_R	711_L	0.914	0.98
440_A	458_L	0.911	0.98
561_K	600_Y	0.908	0.98
141_Y	144_G	0.908	0.98
667_V	696_A	0.907	0.98
301_F	304_C	0.905	0.98
553_L	557_E	0.904	0.98
548_S	580_M	0.903	0.98
594_I	629_Q	0.901	0.98
361_E	399_S	0.898	0.97
171_S	175_A	0.897	0.97
679_I	682_S	0.896	0.97
383_L	393_L	0.896	0.97
276_N	280_N	0.895	0.97
427_H	432_G	0.893	0.97
360_L	376_I	0.893	0.97
254_G	257_K	0.890	0.97
231_C	234_Y	0.889	0.97
391_E	416_H	0.889	0.97
224_S	227_L	0.888	0.97
414_L	439_A	0.884	0.97
542_I	546_N	0.884	0.97
403_L	417_M	0.883	0.97
545_F	549_A	0.879	0.97
379_I	421_L	0.878	0.97
526_L	531_G	0.877	0.97
188_R	192_S	0.877	0.97
509_Q	717_Q	0.877	0.97
659_I	715_Y	0.875	0.97
670_I	680_V	0.869	0.97
516_G	716_L	0.869	0.97
356_R	372_R	0.867	0.97
523_L	640_D	0.867	0.97
306_L	311_I	0.867	0.97
320_R	323_H	0.867	0.97
126_F	130_L	0.866	0.97
523_L	578_N	0.864	0.97
563_L	600_Y	0.863	0.97
312_Y	319_N	0.861	0.97
668_K	704_Q	0.860	0.97
557_E	561_K	0.860	0.97
661_K	717_Q	0.860	0.97
344_P	404_V	0.857	0.97
684_T	688_K	0.857	0.97
561_K	565_T	0.855	0.97
440_A	461_L	0.855	0.97
400_E	466_C	0.855	0.97
361_E	459_S	0.855	0.97
233_P	237_D	0.854	0.97
422_N	471_V	0.854	0.97
127_W	131_V	0.854	0.97
267_W	271_T	0.853	0.97
418_V	474_L	0.852	0.97
371_M	431_T	0.852	0.97
234_Y	237_D	0.852	0.97
400_E	438_G	0.851	0.97
505_L	726_P	0.851	0.97
323_H	327_L	0.850	0.96
518_G	574_R	0.849	0.96
184_Y	191_V	0.848	0.96
511_I	574_R	0.846	0.96
551_F	555_V	0.846	0.96
706_A	709_H	0.846	0.96
358_D	471_V	0.845	0.96
360_L	399_S	0.844	0.96
293_F	302_S	0.844	0.96
372_R	466_C	0.844	0.96
138_C	141_Y	0.841	0.96
375_C	428_W	0.839	0.96
576_S	659_I	0.836	0.96
228_L	234_Y	0.836	0.96
679_I	686_L	0.835	0.96
138_C	143_V	0.834	0.96
676_D	704_Q	0.834	0.96
358_D	469_H	0.834	0.96
693_S	715_Y	0.833	0.96
388_Q	416_H	0.832	0.96
612_T	666_F	0.823	0.96
222_A	225_V	0.822	0.96
189_M	192_S	0.821	0.96
164_F	171_S	0.820	0.96
645_G	697_E	0.820	0.96
169_L	174_T	0.820	0.96
331_L	364_S	0.818	0.96
169_L	175_A	0.818	0.96
220_L	224_S	0.818	0.96
355_L	403_L	0.818	0.96
593_I	596_L	0.817	0.96
530_G	533_M	0.816	0.96
301_F	305_L	0.816	0.96
169_L	173_F	0.812	0.95
577_V	609_L	0.812	0.95
617_F	651_R	0.809	0.95
350_K	444_F	0.807	0.95
192_S	196_A	0.806	0.95
682_S	686_L	0.804	0.95
533_M	540_P	0.804	0.95
578_N	717_Q	0.804	0.95
438_G	466_C	0.803	0.95
444_F	448_Q	0.803	0.95
379_I	383_L	0.803	0.95
229_L	234_Y	0.800	0.95
356_R	360_L	0.798	0.95
695_V	715_Y	0.796	0.95
523_L	612_T	0.796	0.95
624_M	656_Q	0.792	0.95
563_L	575_F	0.791	0.95
291_L	294_I	0.791	0.95
492_L	541_L	0.791	0.95
319_N	322_W	0.791	0.95
189_M	194_H	0.790	0.95
183_F	188_R	0.790	0.95
398_G	459_S	0.788	0.95
491_L	494_T	0.786	0.95
553_L	596_L	0.780	0.94
319_N	323_H	0.779	0.94
548_S	552_D	0.777	0.94
410_T	413_R	0.775	0.94
438_G	470_H	0.775	0.94
661_K	697_E	0.775	0.94
225_V	233_P	0.772	0.94
596_L	599_R	0.772	0.94
521_E	610_E	0.771	0.94
498_A	551_F	0.770	0.94
229_L	235_E	0.769	0.94
669_D	672_T	0.769	0.94
226_L	236_N	0.768	0.94
166_V	170_L	0.768	0.94
264_N	267_W	0.768	0.94
608_I	636_R	0.767	0.94
226_L	229_L	0.765	0.94
438_G	463_E	0.764	0.94
609_L	637_I	0.764	0.94
415_Q	418_V	0.762	0.94
365_R	398_G	0.761	0.94
565_T	568_C	0.761	0.94
330_P	333_L	0.759	0.93
610_E	717_Q	0.757	0.93
662_I	666_F	0.756	0.93
135_G	142_L	0.756	0.93
511_I	608_I	0.755	0.93
490_L	494_T	0.755	0.93
514_K	699_V	0.755	0.93
562_W	565_T	0.755	0.93
344_P	352_F	0.754	0.93
332_T	376_I	0.754	0.93
227_L	231_C	0.754	0.93
118_S	123_Q	0.754	0.93
292_A	295_L	0.753	0.93
300_S	304_C	0.752	0.93
366_H	489_V	0.750	0.93
521_E	717_Q	0.745	0.93
297_V	301_F	0.745	0.93
342_Q	346_Q	0.744	0.93
294_I	297_V	0.744	0.93
361_E	400_E	0.743	0.93
580_M	612_T	0.742	0.93
328_T	339_A	0.741	0.93
508_A	566_H	0.739	0.93
371_M	374_H	0.739	0.93
309_V	313_H	0.739	0.93
547_L	550_R	0.738	0.93
120_Y	124_R	0.738	0.93
311_I	319_N	0.737	0.92
409_E	413_R	0.734	0.92
276_N	279_Q	0.734	0.92
246_V	257_K	0.733	0.92
549_A	583_T	0.733	0.92
211_E	214_A	0.733	0.92
549_A	586_Q	0.732	0.92
266_T	269_V	0.732	0.92
170_L	176_V	0.731	0.92
361_E	369_L	0.731	0.92
619_N	622_S	0.730	0.92
270_S	280_N	0.728	0.92
653_K	673_N	0.726	0.92
523_L	610_E	0.726	0.92
559_L	577_V	0.726	0.92
291_L	297_V	0.724	0.92
343_A	394_Y	0.724	0.92
591_G	595_R	0.723	0.92
549_A	552_D	0.721	0.92
118_S	124_R	0.721	0.92
578_N	613_E	0.720	0.92
519_Y	573_P	0.720	0.92
361_E	438_G	0.719	0.92
684_T	708_L	0.718	0.91
356_R	365_R	0.716	0.91
422_N	426_I	0.714	0.91
517_E	709_H	0.714	0.91
382_T	426_I	0.714	0.91
506_L	522_I	0.714	0.91
222_A	229_L	0.713	0.91
118_S	122_W	0.713	0.91
119_R	124_R	0.712	0.91
166_V	173_F	0.710	0.91
398_G	438_G	0.710	0.91
584_L	627_I	0.709	0.91
590_A	629_Q	0.709	0.91
228_L	232_T	0.709	0.91
523_L	613_E	0.708	0.91
185_Y	189_M	0.707	0.91
212_K	215_F	0.707	0.91
254_G	258_L	0.706	0.91
369_L	400_E	0.706	0.91
357_I	459_S	0.705	0.91
442_G	457_Q	0.705	0.91
313_H	317_W	0.702	0.91
525_R	697_E	0.702	0.91
445_D	457_Q	0.701	0.90
641_D	645_G	0.701	0.90
373_V	395_Q	0.700	0.90
511_I	576_S	0.699	0.90
166_V	176_V	0.698	0.90
702_Q	705_Q	0.696	0.90
264_N	271_T	0.695	0.90
459_S	466_C	0.695	0.90
388_Q	408_P	0.695	0.90
165_T	171_S	0.695	0.90
364_S	376_I	0.694	0.90
215_F	218_S	0.694	0.90
564_A	567_P	0.691	0.90
306_L	313_H	0.691	0.90
330_P	338_R	0.691	0.90
418_V	422_N	0.690	0.90
227_L	233_P	0.689	0.90
419_N	423_S	0.689	0.90
625_Y	629_Q	0.688	0.90
610_E	697_E	0.687	0.90
533_M	537_K	0.687	0.90
224_S	234_Y	0.686	0.90
269_V	273_C	0.685	0.89
372_R	397_P	0.683	0.89
400_E	463_E	0.683	0.89
232_T	236_N	0.683	0.89
659_I	693_S	0.681	0.89
243_L	246_V	0.680	0.89
246_V	256_G	0.679	0.89
500_D	550_R	0.678	0.89
420_I	423_S	0.675	0.89
436_G	469_H	0.674	0.89
223_L	229_L	0.674	0.89
290_S	293_F	0.673	0.89
552_D	579_L	0.673	0.89
548_S	582_L	0.673	0.89
594_I	598_K	0.673	0.89
337_F	459_S	0.673	0.89
418_V	471_V	0.672	0.89
230_L	236_N	0.672	0.89
508_A	575_F	0.672	0.89
353_C	403_L	0.672	0.89
508_A	519_Y	0.671	0.89
158_G	161_D	0.670	0.88
363_M	372_R	0.670	0.88
295_L	301_F	0.669	0.88
628_E	656_Q	0.667	0.88
387_M	403_L	0.667	0.88
121_V	124_R	0.664	0.88
260_Y	266_T	0.664	0.88
120_Y	123_Q	0.664	0.88
555_V	577_V	0.662	0.88
654_R	675_L	0.660	0.88
612_T	646_Y	0.660	0.88
494_T	531_G	0.660	0.88
225_V	230_L	0.660	0.88
190_I	194_H	0.659	0.88
293_F	296_A	0.659	0.88
131_V	135_G	0.659	0.88
552_D	555_V	0.659	0.88
453_P	457_Q	0.658	0.88
578_N	719_Y	0.658	0.88
539_L	542_I	0.658	0.88
331_L	372_R	0.656	0.87
383_L	417_M	0.656	0.87
460_W	481_V	0.656	0.87
326_A	361_E	0.655	0.87
444_F	447_N	0.654	0.87
262_F	265_L	0.654	0.87
359_N	362_F	0.653	0.87
360_L	372_R	0.653	0.87
173_F	179_Y	0.653	0.87
549_A	582_L	0.653	0.87
155_T	158_G	0.652	0.87
485_T	489_V	0.651	0.87
329_D	395_Q	0.651	0.87
130_L	135_G	0.650	0.87
260_Y	265_L	0.650	0.87
369_L	399_S	0.650	0.87
357_I	463_E	0.649	0.87
610_E	640_D	0.649	0.87
579_L	593_I	0.648	0.87
442_G	454_L	0.648	0.87
268_A	273_C	0.647	0.87
497_T	500_D	0.647	0.87
525_R	578_N	0.646	0.87
188_R	191_V	0.646	0.87
122_W	127_W	0.644	0.86
578_N	697_E	0.643	0.86
297_V	300_S	0.643	0.86
560_L	600_Y	0.643	0.86
229_L	232_T	0.641	0.86
265_L	276_N	0.641	0.86
593_I	609_L	0.641	0.86
125_L	128_L	0.641	0.86
249_I	254_G	0.638	0.86
266_T	277_Y	0.637	0.86
380_C	393_L	0.636	0.86
222_A	228_L	0.636	0.86
140_M	144_G	0.636	0.86
358_D	369_L	0.636	0.86
358_D	361_E	0.635	0.86
290_S	294_I	0.634	0.86
171_S	174_T	0.634	0.86
231_C	235_E	0.634	0.86
498_A	504_L	0.633	0.85
495_I	542_I	0.633	0.85
545_F	582_L	0.633	0.85
511_I	611_I	0.632	0.85
166_V	169_L	0.632	0.85
463_E	466_C	0.631	0.85
660_I	692_L	0.631	0.85
147_F	155_T	0.631	0.85
364_S	400_E	0.631	0.85
505_L	728_A	0.629	0.85
139_S	143_V	0.628	0.85
272_L	275_L	0.628	0.85
578_N	700_E	0.628	0.85
130_L	133_P	0.627	0.85
671_V	701_T	0.627	0.85
131_V	134_I	0.627	0.85
164_F	167_V	0.626	0.85
590_A	594_I	0.625	0.85
647_A	651_R	0.623	0.85
138_C	144_G	0.622	0.84
597_F	600_Y	0.621	0.84
295_L	300_S	0.620	0.84
262_F	266_T	0.620	0.84
168_D	175_A	0.619	0.84
266_T	270_S	0.619	0.84
365_R	397_P	0.619	0.84
249_I	253_L	0.618	0.84
324_L	333_L	0.616	0.84
708_L	713_V	0.616	0.84
509_Q	523_L	0.616	0.84
218_S	236_N	0.615	0.84
268_A	271_T	0.614	0.84
343_A	404_V	0.613	0.84
193_P	198_I	0.613	0.84
492_L	545_F	0.613	0.84
365_R	372_R	0.611	0.83
315_S	322_W	0.610	0.83
386_L	417_M	0.609	0.83
251_F	255_V	0.609	0.83
636_R	693_S	0.608	0.83
122_W	130_L	0.607	0.83
356_R	398_G	0.606	0.83
239_I	243_L	0.606	0.83
523_L	719_Y	0.606	0.83
352_F	454_L	0.603	0.83
169_L	176_V	0.602	0.83
445_D	454_L	0.602	0.83
395_Q	400_E	0.601	0.82
263_L	266_T	0.601	0.82
266_T	274_L	0.601	0.82
539_L	543_A	0.600	0.82
141_Y	145_S	0.599	0.82
372_R	400_E	0.599	0.82
356_R	395_Q	0.598	0.82
365_R	400_E	0.598	0.82
218_S	225_V	0.598	0.82
308_M	313_H	0.598	0.82
167_V	171_S	0.598	0.82
291_L	295_L	0.598	0.82
609_L	635_F	0.597	0.82
437_Y	462_A	0.597	0.82
641_D	644_T	0.596	0.82
273_C	276_N	0.596	0.82
367_Y	431_T	0.596	0.82
128_L	132_T	0.595	0.82
221_A	229_L	0.593	0.82
548_S	612_T	0.593	0.82
118_S	121_V	0.593	0.82
631_H	656_Q	0.593	0.82
535_P	538_F	0.592	0.81
162_A	165_T	0.591	0.81
361_E	462_A	0.591	0.81
169_L	177_L	0.590	0.81
351_S	441_W	0.590	0.81
267_W	270_S	0.590	0.81
187_T	190_I	0.589	0.81
613_E	640_D	0.589	0.81
186_L	196_A	0.589	0.81
597_F	604_P	0.589	0.81
685_D	689_A	0.588	0.81
224_S	228_L	0.588	0.81
121_V	127_W	0.588	0.81
386_L	416_H	0.588	0.81
371_M	433_L	0.586	0.81
506_L	556_L	0.586	0.81
350_K	454_L	0.585	0.81
578_N	641_D	0.585	0.81
168_D	171_S	0.585	0.81
624_M	654_R	0.584	0.81
186_L	190_I	0.583	0.80
162_A	166_V	0.583	0.80
396_L	455_L	0.578	0.80
183_F	186_L	0.578	0.80
584_L	626_N	0.577	0.80
138_C	145_S	0.577	0.80
356_R	438_G	0.576	0.80
136_I	139_S	0.576	0.80
418_V	436_G	0.576	0.80
526_L	713_V	0.576	0.80
163_I	170_L	0.576	0.80
186_L	193_P	0.574	0.79
505_L	533_M	0.574	0.79
188_R	195_F	0.573	0.79
592_R	595_R	0.573	0.79
377_R	381_R	0.572	0.79
211_E	215_F	0.572	0.79
233_P	236_N	0.572	0.79
610_E	613_E	0.572	0.79
188_R	196_A	0.571	0.79
290_S	296_A	0.570	0.79
135_G	139_S	0.569	0.79
438_G	459_S	0.569	0.79
230_L	235_E	0.568	0.79
700_E	719_Y	0.567	0.79
612_T	644_T	0.567	0.79
260_Y	264_N	0.567	0.79
509_Q	700_E	0.566	0.78
498_A	666_F	0.565	0.78
239_I	242_Y	0.565	0.78
227_L	232_T	0.562	0.78
165_T	169_L	0.562	0.78
521_E	640_D	0.561	0.78
464_Q	475_D	0.561	0.78
171_S	177_L	0.559	0.78
360_L	438_G	0.559	0.78
513_N	517_E	0.558	0.78
356_R	459_S	0.558	0.78
223_L	237_D	0.558	0.78
673_N	676_D	0.557	0.77
620_A	623_S	0.557	0.77
356_R	397_P	0.557	0.77
629_Q	632_K	0.556	0.77
137_K	141_Y	0.556	0.77
186_L	192_S	0.555	0.77
188_R	202_R	0.554	0.77
574_R	606_A	0.554	0.77
298_L	304_C	0.554	0.77
443_R	476_S	0.554	0.77
577_V	593_I	0.553	0.77
306_L	312_Y	0.552	0.77
277_Y	280_N	0.552	0.77
219_W	226_L	0.551	0.77
253_L	257_K	0.550	0.77
372_R	398_G	0.550	0.77
228_L	237_D	0.550	0.77
291_L	301_F	0.550	0.77
373_V	398_G	0.549	0.76
219_W	223_L	0.548	0.76
684_T	714_Q	0.547	0.76
459_S	462_A	0.547	0.76
663_D	666_F	0.546	0.76
265_L	268_A	0.546	0.76
563_L	606_A	0.545	0.76
631_H	637_I	0.545	0.76
642_F	700_E	0.545	0.76
227_L	230_L	0.545	0.76
170_L	175_A	0.544	0.76
612_T	640_D	0.544	0.76
613_E	645_G	0.543	0.76
700_E	704_Q	0.543	0.76
186_L	198_I	0.543	0.76
324_L	327_L	0.542	0.75
251_F	257_K	0.542	0.75
270_S	274_L	0.541	0.75
221_A	225_V	0.541	0.75
356_R	373_V	0.541	0.75
397_P	438_G	0.540	0.75
670_I	708_L	0.540	0.75
360_L	369_L	0.539	0.75
309_V	315_S	0.539	0.75
519_Y	575_F	0.538	0.75
130_L	142_L	0.538	0.75
645_G	648_N	0.536	0.75
167_V	170_L	0.535	0.75
514_K	517_E	0.535	0.75
647_A	697_E	0.535	0.75
491_L	530_G	0.535	0.75
525_R	610_E	0.534	0.74
615_Q	651_R	0.533	0.74
224_S	232_T	0.532	0.74
141_Y	146_F	0.532	0.74
215_F	230_L	0.532	0.74
185_Y	193_P	0.530	0.74
188_R	193_P	0.530	0.74
220_L	229_L	0.530	0.74
299_I	303_V	0.530	0.74
371_M	428_W	0.530	0.74
166_V	179_Y	0.530	0.74
344_P	350_K	0.530	0.74
380_C	387_M	0.529	0.74
271_T	275_L	0.529	0.74
163_I	166_V	0.528	0.74
341_E	345_E	0.528	0.74
593_I	635_F	0.528	0.74
391_E	405_L	0.528	0.74
539_L	697_E	0.527	0.73
327_L	335_P	0.527	0.73
119_R	123_Q	0.527	0.73
232_T	235_E	0.527	0.73
565_T	569_D	0.527	0.73
366_H	485_T	0.527	0.73
626_N	629_Q	0.526	0.73
290_S	301_F	0.526	0.73
543_A	612_T	0.525	0.73
224_S	233_P	0.525	0.73
509_Q	640_D	0.525	0.73
525_R	535_P	0.525	0.73
679_I	683_I	0.524	0.73
644_T	665_V	0.524	0.73
586_Q	590_A	0.523	0.73
602_I	607_V	0.523	0.73
138_C	142_L	0.523	0.73
392_K	404_V	0.522	0.73
150_P	154_S	0.522	0.73
163_I	171_S	0.522	0.73
260_Y	267_W	0.522	0.73
640_D	717_Q	0.521	0.73
504_L	551_F	0.521	0.73
447_N	457_Q	0.521	0.73
707_L	710_K	0.521	0.73
515_E	714_Q	0.518	0.72
292_A	296_A	0.518	0.72
651_R	654_R	0.517	0.72
196_A	200_W	0.517	0.72
479_E	483_G	0.516	0.72
131_V	141_Y	0.514	0.72
327_L	339_A	0.513	0.71
308_M	315_S	0.513	0.71
274_L	278_N	0.513	0.71
572_G	606_A	0.513	0.71
245_P	249_I	0.513	0.71
164_F	176_V	0.513	0.71
173_F	176_V	0.512	0.71
663_D	697_E	0.511	0.71
622_S	625_Y	0.511	0.71
343_A	406_S	0.511	0.71
307_Y	315_S	0.510	0.71
415_Q	474_L	0.510	0.71
369_L	397_P	0.510	0.71
695_V	716_L	0.510	0.71
275_L	279_Q	0.509	0.71
304_C	311_I	0.509	0.71
124_R	131_V	0.507	0.71
314_R	318_L	0.507	0.71
577_V	596_L	0.506	0.70
186_L	194_H	0.506	0.70
261_P	265_L	0.506	0.70
640_D	719_Y	0.506	0.70
163_I	173_F	0.505	0.70
135_G	143_V	0.502	0.70
225_V	236_N	0.502	0.70
218_S	229_L	0.502	0.70
442_G	458_L	0.502	0.70
221_A	232_T	0.502	0.70
377_R	380_C	0.501	0.70
292_A	297_V	0.501	0.70
318_L	321_R	0.500	0.70
293_F	297_V	0.500	0.70
189_M	193_P	0.500	0.70
276_N	281_F	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rnhA	2	0.5432	100	0.358	Contact Map
4j40A	2	0.3333	100	0.365	Contact Map
3pjxA	1	0.5542	100	0.381	Contact Map
3gfzA	2	0.4925	100	0.464	Contact Map
4hjfA	1	0.3347	100	0.506	Contact Map
3sy8A	6	0.5171	100	0.58	Contact Map
4hu4A	1	0.3155	100	0.582	Contact Map
4kieA	1	0.3416	100	0.585	Contact Map
2r6oA	2	0.3306	100	0.587	Contact Map
4rniA	2	0.332	100	0.588	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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