GREMLIN Database
XAPR - HTH-type transcriptional regulator XapR
UniProt: P23841 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11146
Length: 294 (281)
Sequences: 79214 (57518)
Seq/√Len: 3431.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_R80_N3.6511.00
21_E30_R3.4621.00
102_G147_L2.6031.00
73_E87_R2.4551.00
238_V245_T2.3921.00
171_A249_D2.3351.00
180_H196_E2.2611.00
166_R169_E2.2401.00
169_E271_D2.2311.00
17_A30_R2.2161.00
20_E75_R2.2001.00
26_R29_A2.1961.00
98_R129_L2.1751.00
98_R127_D2.1521.00
189_P192_A2.1191.00
16_L71_M2.0581.00
166_R271_D2.0541.00
51_T66_A2.0341.00
14_Y41_H2.0311.00
100_E129_L2.0311.00
169_E269_P1.9771.00
73_E80_N1.9751.00
17_A20_E1.9471.00
14_Y38_L1.9351.00
199_V243_G1.9281.00
24_F42_I1.9271.00
77_L81_A1.9201.00
16_L75_R1.9161.00
19_A63_L1.8901.00
17_A21_E1.8801.00
16_L20_E1.8771.00
71_M75_R1.8501.00
173_L249_D1.8211.00
185_F192_A1.7991.00
138_Q150_G1.7971.00
118_R291_A1.7901.00
55_I62_V1.7831.00
70_L84_V1.7651.00
256_W259_V1.7451.00
197_Y225_I1.7271.00
235_L255_N1.7131.00
239_S255_N1.6951.00
69_I87_R1.6891.00
141_L146_E1.6831.00
20_E30_R1.6651.00
164_S273_Y1.6581.00
15_F71_M1.6381.00
119_F288_L1.6371.00
16_L74_S1.6001.00
19_A71_M1.6001.00
14_Y33_M1.5871.00
119_F126_V1.5781.00
25_G35_Q1.5691.00
94_G125_N1.5631.00
65_H68_K1.5591.00
208_W212_Q1.5571.00
163_T278_T1.5561.00
21_E26_R1.5531.00
140_A144_R1.5241.00
11_L41_H1.5231.00
34_S37_P1.4851.00
8_D11_L1.4781.00
11_L48_Q1.4721.00
16_L78_L1.4661.00
281_V285_M1.4641.00
52_Q55_I1.4471.00
23_H26_R1.4351.00
165_L276_Y1.4321.00
11_L44_E1.4221.00
17_A31_L1.4191.00
73_E76_R1.4141.00
77_L84_V1.3951.00
73_E83_N1.3931.00
163_T276_Y1.3851.00
152_W275_V1.3761.00
9_L81_A1.3741.00
149_A285_M1.3671.00
96_A125_N1.3551.00
154_M273_Y1.3511.00
274_I289_L1.3491.00
109_W232_Q1.3481.00
143_E161_G1.3301.00
48_Q85_L1.3261.00
100_E131_R1.3161.00
176_M244_I1.3031.00
196_E244_I1.2981.00
70_L85_L1.2951.00
120_L225_I1.2821.00
118_R122_E1.2801.00
141_L147_L1.2741.00
149_A274_I1.2721.00
170_S250_S1.2711.00
234_V245_T1.2671.00
57_H62_V1.2631.00
43_K47_N1.2631.00
276_Y289_L1.2581.00
68_K72_E1.2561.00
176_M262_R1.2531.00
249_D253_Q1.2351.00
215_C220_F1.2341.00
80_N83_N1.2311.00
236_A239_S1.2121.00
287_K290_A1.2121.00
72_E76_R1.2091.00
181_H196_E1.1961.00
118_R121_R1.1951.00
120_L197_Y1.1921.00
69_I72_E1.1911.00
15_F54_F1.1881.00
117_R121_R1.1861.00
178_E258_G1.1841.00
73_E84_V1.1781.00
249_D263_P1.1721.00
199_V234_V1.1711.00
173_L263_P1.1691.00
186_S262_R1.1631.00
99_I288_L1.1521.00
39_S43_K1.1511.00
239_S260_I1.1491.00
13_R82_N1.1491.00
15_F53_L1.1451.00
166_R273_Y1.1431.00
40_I43_K1.1401.00
277_E280_Q1.1391.00
15_F19_A1.1341.00
164_S275_V1.1321.00
33_M37_P1.1261.00
129_L227_E1.1181.00
228_V234_V1.1121.00
24_F61_V1.1051.00
18_V27_A1.1041.00
10_K13_R1.1011.00
40_I44_E1.0951.00
76_R83_N1.0941.00
178_E260_I1.0921.00
119_F291_A1.0851.00
12_L74_S1.0831.00
117_R240_M1.0821.00
108_M132_E1.0801.00
197_Y223_V1.0761.00
123_N287_K1.0761.00
253_Q257_P1.0751.00
254_M258_G1.0671.00
17_A27_A1.0671.00
77_L80_N1.0661.00
63_L67_G1.0621.00
41_H44_E1.0611.00
177_P241_G1.0581.00
188_V192_A1.0331.00
235_L239_S1.0301.00
286_V290_A1.0261.00
69_I73_E1.0171.00
174_V244_I1.0121.00
175_A252_A1.0091.00
114_P240_M1.0021.00
143_E159_P0.9991.00
209_D212_Q0.9991.00
82_N86_A0.9991.00
187_T265_K0.9961.00
85_L89_E0.9941.00
236_A240_M0.9911.00
82_N85_L0.9901.00
19_A54_F0.9841.00
14_Y31_L0.9841.00
171_A263_P0.9781.00
142_L150_G0.9771.00
33_M38_L0.9771.00
119_F123_N0.9751.00
161_G278_T0.9751.00
176_M180_H0.9521.00
15_F63_L0.9501.00
228_V237_M0.9481.00
200_T224_V0.9461.00
180_H183_S0.9451.00
102_G152_W0.9431.00
79_V83_N0.9431.00
70_L74_S0.9411.00
255_N260_I0.9331.00
18_V24_F0.9331.00
282_T285_M0.9331.00
19_A67_G0.9311.00
180_H197_Y0.9301.00
51_T88_I0.9291.00
156_T159_P0.9221.00
122_E291_A0.9211.00
115_V291_A0.9211.00
263_P266_Q0.9191.00
255_N258_G0.9171.00
15_F45_L0.9151.00
171_A269_P0.9131.00
27_A38_L0.9111.00
54_F61_V0.9111.00
127_D223_V0.9101.00
239_S258_G0.9061.00
131_R141_L0.8961.00
44_E47_N0.8941.00
141_L144_R0.8921.00
198_F222_P0.8911.00
137_M140_A0.8881.00
176_M181_H0.8861.00
147_L150_G0.8841.00
192_A195_D0.8811.00
26_R30_R0.8791.00
72_E75_R0.8791.00
184_S197_Y0.8691.00
22_L62_V0.8631.00
162_F275_V0.8621.00
25_G29_A0.8611.00
102_G138_Q0.8591.00
180_H184_S0.8541.00
197_Y224_V0.8511.00
105_G230_E0.8491.00
126_V284_A0.8491.00
175_A245_T0.8461.00
154_M271_D0.8461.00
9_L78_L0.8431.00
101_L149_A0.8401.00
31_L38_L0.8361.00
102_G150_G0.8331.00
57_H60_S0.8321.00
165_L289_L0.8301.00
181_H186_S0.8291.00
10_K41_H0.8271.00
18_V42_I0.8261.00
139_M143_E0.8221.00
163_T166_R0.8191.00
209_D213_R0.8161.00
76_R79_V0.8161.00
43_K52_Q0.8101.00
22_L68_K0.8071.00
131_R147_L0.8031.00
281_V286_V0.8031.00
66_A88_I0.8001.00
175_A261_F0.8001.00
191_E194_R0.7921.00
179_E183_S0.7911.00
15_F70_L0.7881.00
143_E162_F0.7841.00
182_L196_E0.7831.00
117_R242_I0.7811.00
18_V54_F0.7801.00
97_G284_A0.7781.00
19_A22_L0.7781.00
97_G126_V0.7771.00
95_E123_N0.7771.00
211_L215_C0.7771.00
35_Q39_S0.7761.00
89_E92_G0.7741.00
214_V218_V0.7721.00
177_P242_I0.7721.00
20_E71_M0.7691.00
208_W227_E0.7691.00
149_A288_L0.7681.00
69_I91_I0.7601.00
254_M257_P0.7591.00
80_N84_V0.7581.00
237_M242_I0.7541.00
21_E27_A0.7531.00
81_A84_V0.7491.00
62_V68_K0.7461.00
63_L68_K0.7461.00
259_V263_P0.7461.00
11_L14_Y0.7431.00
83_N87_R0.7311.00
22_L60_S0.7291.00
66_A91_I0.7291.00
66_A69_I0.7271.00
100_E147_L0.7241.00
175_A247_I0.7231.00
84_V88_I0.7221.00
255_N259_V0.7201.00
191_E218_V0.7191.00
283_P287_K0.7191.00
74_S77_L0.7171.00
55_I64_T0.7171.00
120_L242_I0.7161.00
176_M182_L0.7091.00
119_F287_K0.7061.00
81_A85_L0.7061.00
195_D223_V0.7021.00
24_F38_L0.7021.00
122_E287_K0.7021.00
177_P180_H0.7001.00
189_P265_K0.7001.00
194_R220_F0.7001.00
37_P41_H0.7001.00
13_R17_A0.6991.00
55_I60_S0.6981.00
213_R216_Q0.6961.00
103_V108_M0.6951.00
18_V38_L0.6921.00
46_E51_T0.6881.00
74_S78_L0.6861.00
99_I284_A0.6831.00
66_A70_L0.6821.00
214_V217_Q0.6811.00
145_R277_E0.6801.00
100_E148_D0.6791.00
248_A251_Y0.6781.00
230_E233_T0.6741.00
103_V112_M0.6711.00
226_R237_M0.6671.00
24_F60_S0.6671.00
208_W214_V0.6661.00
79_V82_N0.6611.00
213_R217_Q0.6611.00
260_I263_P0.6571.00
137_M141_L0.6571.00
201_M234_V0.6551.00
75_R79_V0.6551.00
46_E56_R0.6521.00
182_L185_F0.6511.00
27_A31_L0.6501.00
148_D285_M0.6491.00
179_E182_L0.6481.00
140_A143_E0.6471.00
215_C222_P0.6471.00
202_P227_E0.6431.00
127_D227_E0.6431.00
83_N86_A0.6381.00
68_K71_M0.6371.00
211_L214_V0.6341.00
212_Q216_Q0.6321.00
96_A127_D0.6311.00
65_H69_I0.6291.00
209_D214_V0.6291.00
132_E229_N0.6281.00
70_L88_I0.6271.00
29_A32_N0.6261.00
112_M115_V0.6241.00
10_K44_E0.6221.00
252_A255_N0.6211.00
198_F244_I0.6211.00
256_W261_F0.6201.00
175_A256_W0.6201.00
42_I46_E0.6191.00
69_I88_I0.6191.00
210_F214_V0.6161.00
174_V193_L0.6161.00
18_V23_H0.6151.00
173_L261_F0.6131.00
179_E241_G0.6111.00
254_M259_V0.6091.00
168_H272_L0.6091.00
13_R16_L0.6081.00
163_T279_Q0.6071.00
73_E77_L0.6051.00
109_W236_A0.5991.00
63_L71_M0.5981.00
182_L188_V0.5951.00
181_H185_F0.5951.00
174_V198_F0.5941.00
234_V238_V0.5941.00
237_M243_G0.5941.00
283_P286_V0.5941.00
259_V266_Q0.5911.00
187_T192_A0.5911.00
99_I149_A0.5901.00
202_P229_N0.5891.00
172_F246_L0.5881.00
151_I274_I0.5811.00
210_F213_R0.5801.00
174_V246_L0.5801.00
276_Y286_V0.5781.00
86_A90_Q0.5781.00
36_P40_I0.5781.00
116_M128_V0.5761.00
212_Q215_C0.5741.00
132_E230_E0.5721.00
149_A289_L0.5721.00
51_T55_I0.5701.00
8_D48_Q0.5641.00
10_K14_Y0.5611.00
34_S40_I0.5581.00
256_W263_P0.5571.00
37_P40_I0.5561.00
54_F63_L0.5561.00
78_L81_A0.5551.00
72_E87_R0.5551.00
49_L70_L0.5511.00
42_I54_F0.5501.00
49_L88_I0.5501.00
74_S81_A0.5481.00
114_P117_R0.5481.00
228_V233_T0.5471.00
285_M289_L0.5471.00
287_K291_A0.5461.00
107_A111_R0.5461.00
142_L275_V0.5451.00
97_G125_N0.5421.00
259_V262_R0.5421.00
109_W230_E0.5411.00
203_P227_E0.5411.00
114_P118_R0.5411.00
140_A146_E0.5401.00
208_W211_L0.5391.00
49_L52_Q0.5391.00
247_I252_A0.5391.00
102_G131_R0.5351.00
176_M183_S0.5331.00
14_Y42_I0.5271.00
90_Q95_E0.5261.00
13_R78_L0.5251.00
181_H184_S0.5251.00
142_L162_F0.5241.00
185_F188_V0.5211.00
73_E88_I0.5181.00
239_S256_W0.5181.00
97_G123_N0.5161.00
231_P248_A0.5161.00
52_Q66_A0.5151.00
24_F35_Q0.5111.00
123_N126_V0.5111.00
180_H244_I0.5111.00
14_Y27_A0.5101.00
78_L82_N0.5101.00
145_R280_Q0.5061.00
154_M164_S0.5031.00
24_F56_R0.5031.00
22_L61_V0.5011.00
170_S270_A0.5001.00
164_S276_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h98A 2 0.6735 100 0.095 Contact Map
1ixcA 4 0.9762 100 0.097 Contact Map
2h9bA 2 0.6735 100 0.1 Contact Map
2esnA 3 0.9898 100 0.102 Contact Map
1uthA 2 0.7313 100 0.109 Contact Map
3fzvA 4 0.9558 100 0.118 Contact Map
1al3A 1 0.6905 100 0.12 Contact Map
4x6gA 4 0.9898 100 0.125 Contact Map
3fxqA 3 0.9762 100 0.128 Contact Map
3szpA 3 0.9626 100 0.142 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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