GREMLIN Database
DIND - DNA-damage-inducible protein D
UniProt: P23840 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11193
Length: 274 (258)
Sequences: 280 (185)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_V72_S11.0921.00
62_E65_L6.2091.00
35_E62_E5.5951.00
37_R62_E5.1011.00
95_G102_I4.6661.00
67_M70_I4.5401.00
35_E65_L4.4931.00
67_M76_R4.2351.00
92_V105_G4.0450.99
68_V71_G3.7970.99
63_E81_I3.5720.98
36_Y66_D3.5310.98
201_T215_E3.4490.98
37_R65_L3.3980.98
70_I76_R3.3760.98
38_H63_E3.3550.98
38_H65_L2.8700.94
67_M71_G2.8310.93
67_M72_S2.7590.92
48_E51_E2.6930.91
43_L91_V2.5950.90
66_D80_D2.4720.87
178_D181_A2.4630.87
68_V74_A2.4190.86
115_R120_D2.4090.86
47_K81_I2.1520.79
238_K245_E2.1520.79
70_I74_A2.1370.78
38_H62_E2.1140.77
69_K75_K2.0030.73
15_N19_A1.9510.71
112_Q115_R1.9450.71
152_Q162_F1.8290.66
41_P65_L1.8260.66
44_T47_K1.8020.65
13_L26_Q1.7960.64
72_S76_R1.7350.62
59_D72_S1.6820.59
204_A211_T1.5970.55
59_D68_V1.5220.51
38_H41_P1.5150.51
241_Q245_E1.4880.50
42_V49_A1.4790.49
204_A207_L1.4770.49
198_M203_L1.4320.47
93_Q112_Q1.3980.45
30_L132_K1.3940.45
36_Y41_P1.3800.44
112_Q136_L1.3730.44
242_T246_L1.3720.44
36_Y80_D1.3480.43
35_E38_H1.3430.43
71_G76_R1.3230.42
38_H45_R1.3120.41
203_L242_T1.2880.40
264_L268_V1.2800.40
42_V45_R1.2720.39
63_E79_K1.2670.39
47_K63_E1.2630.39
41_P45_R1.2550.38
116_Q176_G1.2510.38
161_D225_K1.2460.38
148_V166_Q1.2430.38
67_M75_K1.2390.38
80_D95_G1.2330.37
15_N18_G1.2220.37
14_I17_N1.1980.36
140_L210_A1.1940.36
40_I44_T1.1740.35
54_G58_D1.1430.33
143_H210_A1.1360.33
186_K198_M1.1310.33
167_N222_V1.1300.33
28_G66_D1.1130.32
67_M77_A1.1040.32
93_Q114_R1.1020.32
43_L111_I1.1020.32
45_R62_E1.0900.31
224_S227_Q1.0890.31
28_G36_Y1.0780.31
32_G101_V1.0750.30
47_K57_I1.0650.30
71_G74_A1.0620.30
96_D99_K1.0530.30
102_I257_P1.0510.29
79_K98_A1.0450.29
45_R230_T1.0450.29
139_E207_L1.0440.29
35_E41_P1.0390.29
216_K220_D1.0360.29
165_F174_Y1.0330.29
74_A223_N1.0250.28
186_K203_L1.0130.28
29_K66_D1.0090.28
42_V134_L1.0020.28
177_L185_R0.9960.27
97_P100_P0.9920.27
140_L162_F0.9910.27
45_R63_E0.9880.27
40_I81_I0.9850.27
78_L81_I0.9830.27
134_L268_V0.9770.27
147_L169_G0.9420.25
186_K202_E0.9410.25
141_K149_E0.9400.25
64_I98_A0.9360.25
148_V162_F0.9350.25
100_P115_R0.9300.25
157_A161_D0.9280.25
50_C61_F0.9270.25
100_P104_A0.9220.24
36_Y65_L0.9210.24
155_G224_S0.9140.24
26_Q98_A0.9060.24
199_G254_L0.9050.24
98_A239_V0.8970.24
167_N253_E0.8950.24
63_E70_I0.8880.23
6_Q10_E0.8820.23
192_Q225_K0.8800.23
100_P237_R0.8750.23
28_G37_R0.8740.23
250_M253_E0.8730.23
45_R245_E0.8720.23
29_K36_Y0.8700.23
225_K229_N0.8700.23
92_V101_V0.8680.23
70_I75_K0.8680.23
164_I225_K0.8660.22
213_T231_T0.8630.22
263_Q266_N0.8590.22
234_D238_K0.8550.22
114_R118_L0.8540.22
139_E204_A0.8510.22
139_E143_H0.8450.22
67_M74_A0.8420.22
154_A203_L0.8420.22
217_L228_A0.8370.22
170_Y174_Y0.8330.21
23_S41_P0.8330.21
150_A211_T0.8320.21
17_N264_L0.8310.21
40_I79_K0.8300.21
222_V231_T0.8210.21
154_A198_M0.8150.21
97_P105_G0.8060.21
167_N178_D0.8050.20
111_I118_L0.7980.20
37_R78_L0.7910.20
9_E208_F0.7910.20
52_N97_P0.7900.20
198_M202_E0.7890.20
165_F170_Y0.7890.20
256_T260_S0.7860.20
141_K178_D0.7840.20
23_S178_D0.7810.20
165_F228_A0.7790.20
134_L261_I0.7770.20
15_N82_V0.7750.20
136_L146_Q0.7720.19
209_R236_G0.7710.19
28_G38_H0.7700.19
35_E45_R0.7620.19
164_I210_A0.7590.19
41_P62_E0.7560.19
51_E58_D0.7500.19
237_R241_Q0.7480.19
174_Y236_G0.7460.19
89_Y114_R0.7420.19
42_V78_L0.7410.18
182_I202_E0.7410.18
165_F202_E0.7410.18
235_V246_L0.7380.18
26_Q36_Y0.7360.18
150_A204_A0.7350.18
62_E66_D0.7330.18
154_A224_S0.7300.18
238_K242_T0.7270.18
142_E148_V0.7190.18
113_T117_E0.7170.18
60_H67_M0.7170.18
206_N209_R0.7160.18
104_A179_Q0.7160.18
161_D208_F0.7130.18
102_I120_D0.7120.18
40_I52_N0.7120.18
56_T223_N0.7100.18
98_A104_A0.7100.18
174_Y202_E0.7070.18
175_G202_E0.7040.17
118_L121_D0.7040.17
165_F236_G0.7020.17
238_K241_Q0.7020.17
18_G21_Q0.7000.17
148_V179_Q0.6970.17
175_G182_I0.6960.17
37_R47_K0.6960.17
15_N53_S0.6950.17
20_E25_R0.6950.17
13_L181_A0.6940.17
178_D225_K0.6940.17
47_K261_I0.6930.17
155_G217_L0.6920.17
38_H66_D0.6910.17
146_Q212_Q0.6890.17
10_E48_E0.6890.17
51_E57_I0.6880.17
93_Q115_R0.6830.17
204_A242_T0.6810.17
70_I73_N0.6790.17
32_G105_G0.6780.17
132_K138_N0.6780.17
34_S62_E0.6780.17
212_Q218_K0.6760.17
29_K52_N0.6740.17
128_R146_Q0.6730.17
54_G193_K0.6730.17
21_Q53_S0.6720.17
11_I30_L0.6690.16
132_K139_E0.6680.16
149_E153_Q0.6660.16
153_Q162_F0.6640.16
143_H207_L0.6630.16
59_D67_M0.6620.16
170_Y206_N0.6600.16
136_L211_T0.6580.16
206_N236_G0.6580.16
41_P44_T0.6560.16
186_K194_I0.6530.16
51_E226_Q0.6500.16
34_S227_Q0.6490.16
170_Y236_G0.6480.16
192_Q210_A0.6480.16
130_D208_F0.6460.16
115_R118_L0.6450.16
45_R69_K0.6440.16
150_A220_D0.6400.16
193_K197_H0.6400.16
161_D203_L0.6380.16
232_H255_P0.6380.16
115_R142_E0.6370.16
212_Q215_E0.6350.16
208_F214_E0.6350.16
59_D71_G0.6350.16
182_I229_N0.6290.15
202_E250_M0.6270.15
136_L139_E0.6260.15
107_T208_F0.6250.15
8_F31_L0.6250.15
142_E184_Q0.6230.15
149_E162_F0.6210.15
92_V260_S0.6210.15
34_S38_H0.6200.15
139_E211_T0.6190.15
9_E42_V0.6190.15
174_Y206_N0.6190.15
120_D262_K0.6180.15
23_S26_Q0.6180.15
199_G211_T0.6160.15
264_L269_K0.6140.15
136_L143_H0.6130.15
45_R238_K0.6130.15
156_V214_E0.6120.15
175_G210_A0.6090.15
13_L178_D0.6080.15
111_I185_R0.6070.15
113_T232_H0.6070.15
114_R117_E0.6060.15
152_Q231_T0.6050.15
26_Q55_H0.6030.15
172_G206_N0.6030.15
154_A214_E0.6030.15
154_A186_K0.6030.15
151_A182_I0.6020.15
97_P226_Q0.6000.15
19_A131_E0.5980.15
134_L161_D0.5970.15
143_H183_H0.5970.15
151_A202_E0.5970.15
86_Y107_T0.5970.15
154_A217_L0.5960.15
91_V185_R0.5950.15
59_D73_N0.5930.14
107_T225_K0.5920.14
14_I18_G0.5920.14
163_A230_T0.5890.14
256_T268_V0.5870.14
143_H242_T0.5860.14
252_E255_P0.5860.14
81_I91_V0.5840.14
24_A95_G0.5830.14
66_D257_P0.5830.14
165_F206_N0.5820.14
84_S265_E0.5790.14
34_S65_L0.5770.14
200_S211_T0.5750.14
11_I164_I0.5740.14
202_E217_L0.5740.14
188_L271_T0.5730.14
114_R232_H0.5730.14
198_M242_T0.5720.14
143_H204_A0.5720.14
142_E223_N0.5700.14
200_S254_L0.5690.14
40_I171_Q0.5650.14
211_T231_T0.5630.14
163_A264_L0.5620.14
8_F28_G0.5620.14
56_T258_Q0.5610.14
70_I101_V0.5600.14
174_Y209_R0.5570.14
48_E97_P0.5570.14
174_Y186_K0.5570.14
151_A200_S0.5560.14
174_Y228_A0.5560.14
183_H192_Q0.5550.14
26_Q64_I0.5550.14
82_V156_V0.5550.14
136_L197_H0.5520.14
94_N106_Q0.5520.14
76_R86_Y0.5510.14
8_F27_L0.5510.14
118_L140_L0.5490.13
28_G97_P0.5480.13
28_G81_I0.5480.13
63_E98_A0.5470.13
182_I228_A0.5470.13
212_Q242_T0.5450.13
166_Q183_H0.5440.13
25_R173_L0.5420.13
170_Y209_R0.5410.13
147_L232_H0.5410.13
264_L267_S0.5410.13
203_L208_F0.5410.13
206_N235_V0.5390.13
48_E77_A0.5390.13
188_L218_K0.5370.13
144_N183_H0.5360.13
228_A236_G0.5360.13
51_E56_T0.5350.13
9_E215_E0.5350.13
136_L204_A0.5340.13
100_P226_Q0.5330.13
73_N84_S0.5330.13
169_G232_H0.5330.13
185_R237_R0.5330.13
97_P112_Q0.5310.13
168_H171_Q0.5290.13
172_G235_V0.5280.13
149_E152_Q0.5270.13
43_L269_K0.5270.13
44_T77_A0.5270.13
132_K135_F0.5260.13
142_E269_K0.5240.13
150_A214_E0.5240.13
102_I263_Q0.5220.13
141_K171_Q0.5220.13
20_E173_L0.5210.13
89_Y113_T0.5200.13
216_K243_I0.5200.13
28_G65_L0.5190.13
136_L178_D0.5190.13
235_V243_I0.5170.13
29_K35_E0.5170.13
166_Q210_A0.5160.13
186_K242_T0.5150.13
182_I195_L0.5150.13
165_F209_R0.5140.13
23_S184_Q0.5140.13
66_D102_I0.5130.13
116_Q264_L0.5120.13
175_G255_P0.5120.13
231_T235_V0.5110.13
82_V269_K0.5090.13
153_Q263_Q0.5090.13
13_L23_S0.5090.13
170_Y228_A0.5080.13
66_D78_L0.5080.13
28_G138_N0.5080.13
36_Y120_D0.5040.12
104_A115_R0.5040.12
183_H193_K0.5030.12
53_S107_T0.5030.12
37_R63_E0.5030.12
69_K118_L0.5020.12
61_F87_A0.5000.12
143_H175_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3csxA 2 0.0839 28.1 0.975 Contact Map
3lsgA 2 0.3613 21.8 0.976 Contact Map
1bl0A 1 0.3942 21.1 0.976 Contact Map
1etoA 2 0.3467 18.4 0.977 Contact Map
3oouA 1 0.3613 18 0.977 Contact Map
3oioA 1 0.3869 13.4 0.978 Contact Map
1g6uA 3 0.1533 13.1 0.978 Contact Map
4l5eA 2 0.1679 8.7 0.98 Contact Map
2zhyA 3 0.3431 8.5 0.98 Contact Map
2k9sA 1 0.365 8.3 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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