GREMLIN Database
YICC - UPF0701 protein YicC
UniProt: P23839 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11192
Length: 287 (286)
Sequences: 2340 (1761)
Seq/√Len: 104.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_T229_Y4.5881.00
56_R139_D3.8391.00
171_R222_E3.7121.00
183_E187_A3.3761.00
52_R135_D3.3471.00
82_E94_W3.2011.00
257_A269_A3.1431.00
86_K98_Q3.0591.00
3_R146_E2.8251.00
57_L62_V2.7691.00
26_S141_F2.7481.00
49_V134_L2.7191.00
161_E229_Y2.5331.00
173_H262_N2.4531.00
57_L141_F2.3861.00
22_W66_L2.3821.00
153_K157_E2.3491.00
159_R275_L2.2591.00
163_V272_L2.2461.00
153_K233_K2.1911.00
81_N117_A2.1651.00
179_Q183_E2.1311.00
11_R133_A2.1191.00
105_N108_D2.1131.00
253_S272_L2.1051.00
253_S276_I1.9851.00
56_R142_I1.9011.00
160_L228_T1.8911.00
36_F49_V1.8701.00
85_A95_V1.8671.00
155_L159_R1.8511.00
187_A191_D1.8501.00
53_I64_C1.8471.00
157_E229_Y1.8371.00
155_L219_D1.8341.00
164_T226_K1.8241.00
166_E268_S1.8031.00
156_I279_M1.7951.00
159_R215_A1.7631.00
96_K102_G1.7561.00
53_I138_L1.7341.00
151_A223_A1.7231.00
13_I133_A1.7171.00
146_E150_Q1.7101.00
3_R142_I1.7051.00
82_E98_Q1.6971.00
182_R186_V1.6911.00
89_V93_N1.6321.00
214_V256_L1.6321.00
169_K268_S1.6311.00
131_L135_D1.6291.00
168_V171_R1.5771.00
26_S62_V1.5711.00
144_A227_E1.5701.00
140_D143_V1.5681.00
164_T168_V1.5651.00
186_V190_E1.5421.00
170_V265_V1.5381.00
168_V222_E1.5301.00
127_A131_L1.5271.00
22_W133_A1.5201.00
29_Q61_K1.4921.00
56_R135_D1.4851.00
246_M279_M1.4661.00
221_L249_F1.4521.00
165_A169_K1.4501.00
171_R218_L1.4441.00
173_H180_W1.4411.00
135_D139_D1.4181.00
86_K99_S1.4111.00
11_R137_T1.4091.00
275_L278_Q1.4091.00
231_I245_M1.4091.00
143_V147_T1.4081.00
176_E179_Q1.4001.00
35_Y61_K1.3981.00
143_V146_E1.3711.00
163_V225_V1.3530.99
13_I136_G1.3500.99
173_H264_E1.3300.99
170_V268_S1.3290.99
157_E161_E1.3290.99
269_A276_I1.3280.99
162_G275_L1.3260.99
228_T249_F1.3230.99
154_A158_Q1.3220.99
42_F68_Y1.3120.99
48_V127_A1.3120.99
187_A190_E1.3060.99
9_A137_T1.3010.99
34_T53_I1.2970.99
86_K90_T1.2880.99
186_V198_N1.2860.99
53_I134_L1.2720.99
162_G165_A1.2680.99
208_L212_I1.2630.99
164_T222_E1.2570.99
19_S69_E1.2490.99
122_D125_A1.2280.99
166_E169_K1.2130.99
160_L225_V1.2100.99
11_R136_G1.2050.99
225_V249_F1.2020.99
150_Q153_K1.1970.99
89_V99_S1.1960.99
20_A133_A1.1910.99
263_A266_T1.1890.99
22_W134_L1.1810.99
214_V265_V1.1740.99
196_L201_L1.1720.98
169_K172_S1.1710.98
156_I283_I1.1530.98
173_H176_E1.1490.98
179_Q182_R1.1420.98
158_Q162_G1.1320.98
150_Q154_A1.1230.98
53_I57_L1.1180.98
196_L202_E1.1110.98
52_R131_L1.1110.98
48_V131_L1.1020.98
95_V109_I1.0980.98
218_L222_E1.0960.98
82_E86_K1.0960.98
85_A115_V1.0880.98
162_G166_E1.0840.97
226_K230_N1.0790.97
12_E21_T1.0780.97
245_M250_N1.0770.97
88_L112_W1.0770.97
151_A154_A1.0770.97
161_E164_T1.0760.97
81_N84_L1.0750.97
52_R134_L1.0730.97
24_M64_C1.0690.97
55_S135_D1.0680.97
166_E271_E1.0570.97
147_T230_N1.0560.97
162_G271_E1.0540.97
257_A270_I1.0450.97
228_T242_L1.0420.97
263_A267_N1.0360.97
157_E232_L1.0350.97
76_G81_N1.0320.97
177_I265_V1.0310.97
253_S269_A1.0210.96
129_E132_A1.0170.96
51_E55_S1.0170.96
30_R246_M1.0120.96
250_N258_S1.0120.96
157_E233_K1.0030.96
58_T237_A0.9980.96
12_E19_S0.9970.96
102_G105_N0.9920.96
161_E165_A0.9910.96
92_A110_L0.9900.96
90_T94_W0.9850.96
13_I129_E0.9700.95
165_A168_V0.9630.95
24_M53_I0.9610.95
14_K19_S0.9580.95
223_A227_E0.9490.95
243_D284_Q0.9470.95
23_E240_R0.9420.94
34_T50_R0.9410.94
167_V218_L0.9330.94
159_R213_D0.9330.94
174_M177_I0.9260.94
198_N202_E0.9240.94
160_L229_Y0.9200.94
188_K191_D0.9190.94
249_F276_I0.9160.94
163_V249_F0.9120.93
160_L249_F0.9080.93
10_R21_T0.9070.93
258_S266_T0.9070.93
156_I228_T0.9030.93
183_E186_V0.9000.93
35_Y63_E0.8980.93
172_S176_E0.8950.93
124_D128_A0.8910.93
181_Q212_I0.8900.93
135_D138_L0.8900.93
42_F276_I0.8800.92
236_E240_R0.8760.92
167_V222_E0.8730.92
243_D250_N0.8710.92
210_Q274_V0.8700.92
32_L62_V0.8700.92
144_A223_A0.8690.92
237_A240_R0.8670.92
15_G129_E0.8630.91
200_R203_Q0.8620.91
225_V229_Y0.8600.91
2_I238_V0.8510.91
87_Q91_A0.8510.91
96_K99_S0.8410.90
152_L282_Q0.8390.90
164_T225_V0.8390.90
227_E230_N0.8350.90
20_A130_I0.8340.90
215_A219_D0.8320.90
108_D111_R0.8310.90
136_G140_D0.8300.90
230_N234_K0.8260.89
139_D143_V0.8240.89
144_A241_R0.8230.89
267_N271_E0.8150.89
219_D278_Q0.8130.89
52_R55_S0.8130.89
192_A202_E0.8110.89
189_L205_L0.8110.89
270_I274_V0.8100.88
215_A278_Q0.8070.88
13_I20_A0.8060.88
112_W115_V0.8050.88
10_R23_E0.8000.88
57_L142_I0.7990.88
184_R188_K0.7960.88
14_K71_D0.7950.88
172_S175_P0.7900.87
10_R240_R0.7860.87
134_L138_L0.7860.87
11_R140_D0.7840.87
90_T93_N0.7830.87
89_V104_I0.7830.87
79_I119_Q0.7770.86
228_T279_M0.7690.86
147_T150_Q0.7670.86
43_R63_E0.7660.86
181_Q208_L0.7650.85
20_A68_Y0.7630.85
189_L201_L0.7620.85
200_R204_E0.7560.85
132_A136_G0.7550.85
13_I132_A0.7510.84
155_L278_Q0.7480.84
202_E205_L0.7430.84
64_C137_T0.7400.84
263_A270_I0.7380.83
250_N266_T0.7380.83
78_L84_L0.7370.83
27_V63_E0.7310.83
167_V221_L0.7310.83
142_I146_E0.7240.82
130_I133_A0.7230.82
33_E200_R0.7230.82
20_A129_E0.7220.82
228_T269_A0.7200.82
182_R202_E0.7200.82
80_L91_A0.7190.82
29_Q63_E0.7180.82
234_K238_V0.7180.82
163_V167_V0.7170.82
96_K103_E0.7150.81
249_F253_S0.7150.81
22_W25_R0.7140.81
92_A112_W0.7090.81
83_K86_K0.7090.81
147_T227_E0.7080.81
38_L66_L0.7070.81
166_E275_L0.7060.81
50_R54_R0.7020.80
45_L130_I0.7020.80
152_L156_I0.7010.80
9_A210_Q0.6990.80
30_R277_E0.6980.80
179_Q186_V0.6980.80
210_Q278_Q0.6930.79
168_V172_S0.6920.79
202_E206_V0.6900.79
178_L182_R0.6880.79
52_R138_L0.6850.79
203_Q207_L0.6840.78
84_L88_L0.6830.78
175_P178_L0.6810.78
242_L283_I0.6810.78
58_T236_E0.6770.78
38_L49_V0.6760.78
185_L205_L0.6750.78
155_L223_A0.6740.77
212_I266_T0.6700.77
167_V225_V0.6700.77
178_L209_A0.6690.77
201_L207_L0.6610.76
201_L205_L0.6610.76
16_E125_A0.6590.76
29_Q35_Y0.6570.76
173_H177_I0.6570.76
45_L66_L0.6480.75
94_W97_M0.6480.75
42_F126_I0.6470.75
166_E272_L0.6460.74
177_I261_I0.6450.74
65_T240_R0.6450.74
8_Y23_E0.6430.74
93_N96_K0.6400.74
22_W137_T0.6400.74
219_D275_L0.6380.74
73_S83_K0.6370.73
9_A40_E0.6350.73
44_S127_A0.6320.73
190_E193_Q0.6320.73
177_I212_I0.6280.72
155_L158_Q0.6260.72
174_M212_I0.6250.72
135_D150_Q0.6250.72
39_P130_I0.6240.72
124_D127_A0.6220.72
202_E210_Q0.6220.72
174_M178_L0.6170.71
156_I286_I0.6150.71
246_M280_R0.6130.71
221_L276_I0.6130.71
80_L116_M0.6120.70
52_R56_R0.6120.70
170_V256_L0.6100.70
31_Y61_K0.6090.70
78_L91_A0.6090.70
2_I235_K0.6080.70
113_P159_R0.6070.70
24_M138_L0.6050.70
68_Y130_I0.6050.70
136_G139_D0.6030.69
157_E286_I0.6020.69
143_V150_Q0.6020.69
36_F53_I0.6020.69
243_D274_V0.6010.69
253_S256_L0.6000.69
92_A106_P0.6000.69
92_A104_I0.6000.69
2_I153_K0.5990.69
34_T46_E0.5990.69
29_Q33_E0.5990.69
231_I242_L0.5970.69
211_R263_A0.5970.69
222_E226_K0.5960.68
15_G132_A0.5960.68
34_T62_V0.5960.68
29_Q37_R0.5960.68
2_I286_I0.5940.68
95_V106_P0.5900.68
228_T246_M0.5900.68
43_R61_K0.5900.68
36_F46_E0.5900.68
61_K250_N0.5890.68
176_E262_N0.5870.67
199_N203_Q0.5860.67
214_V218_L0.5840.67
53_I185_L0.5840.67
260_S278_Q0.5830.67
235_K238_V0.5830.67
77_E119_Q0.5810.66
92_A109_I0.5810.66
133_A201_L0.5790.66
45_L48_V0.5770.66
64_C134_L0.5760.66
109_I115_V0.5720.65
243_D283_I0.5710.65
210_Q269_A0.5700.65
102_G106_P0.5700.65
243_D266_T0.5700.65
225_V272_L0.5680.65
133_A137_T0.5670.65
87_Q90_T0.5650.64
88_L278_Q0.5650.64
85_A98_Q0.5640.64
185_L207_L0.5640.64
163_V279_M0.5630.64
158_Q161_E0.5630.64
241_R274_V0.5600.64
33_E228_T0.5600.64
213_D256_L0.5600.64
266_T270_I0.5560.63
36_F50_R0.5560.63
56_R138_L0.5560.63
113_P277_E0.5540.63
30_R250_N0.5530.63
63_E257_A0.5530.63
262_N267_N0.5490.62
260_S266_T0.5490.62
37_R48_V0.5480.62
250_N286_I0.5480.62
178_L205_L0.5480.62
40_E43_R0.5470.62
80_L84_L0.5470.62
15_G18_G0.5460.62
108_D112_W0.5450.62
180_W262_N0.5450.62
212_I261_I0.5440.61
104_I107_V0.5420.61
45_L127_A0.5410.61
256_L276_I0.5410.61
51_E54_R0.5400.61
101_E105_N0.5380.61
125_A128_A0.5360.60
245_M274_V0.5350.60
36_F64_C0.5350.60
97_M165_A0.5340.60
128_A132_A0.5330.60
88_L116_M0.5320.60
31_Y240_R0.5320.60
177_I205_L0.5310.60
276_I279_M0.5250.59
250_N280_R0.5240.59
246_M283_I0.5230.58
72_V78_L0.5220.58
219_D240_R0.5190.58
183_E190_E0.5170.58
270_I276_I0.5160.57
178_L188_K0.5160.57
77_E84_L0.5150.57
33_E282_Q0.5140.57
93_N97_M0.5140.57
103_E107_V0.5120.57
96_K101_E0.5110.57
189_L192_A0.5100.57
215_A276_I0.5090.56
229_Y233_K0.5080.56
18_G68_Y0.5070.56
128_A158_Q0.5060.56
29_Q34_T0.5050.56
22_W112_W0.5030.56
154_A157_E0.5010.55
18_G70_P0.5010.55
17_W71_D0.5010.55
280_R286_I0.5010.55
2_I184_R0.5000.55
128_A161_E0.5000.55
241_R271_E0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ll8A 1 0.1394 83.4 0.951 Contact Map
2qywA 1 0.331 45.6 0.963 Contact Map
3al0B 1 0.8432 32.2 0.966 Contact Map
4cg4A 2 0.3659 27.8 0.967 Contact Map
3swyA 3 0.1498 22.6 0.968 Contact Map
2l7bA 1 0.7282 19.4 0.969 Contact Map
3h0lB 1 0.8641 19.2 0.969 Contact Map
2a01A 1 0.5331 17 0.97 Contact Map
2gqpA 1 0.2753 15.5 0.971 Contact Map
2ykoA 3 0.3902 15.4 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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