PHOQ - ECOLI - GREMLIN Contacts

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PHOQ - Sensor protein PhoQ

UniProt:	P23837	Sequences: MKKLLRLFFPLSLRVRFLLATAAVVLVLSLAYGMVALIGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLHVELPENIDKQSPTMTLIYDENGQLLWAQRDVPWLMKMIQPDWLKSNGFHEIEADVNDTSLLLSGDHSIQQQLQEVREDDDDAEMTHSVAVNVYPATSRMPKLTIVVVDTIPVELKSSYMVWSWFIYVLSANLLLVIPLLWVAAWWSLRPIEALAKEVRELEEHNRELLNPATTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVLQSTLRSLRSEKMSVSDAEPVMLEQISRISQQIGYYLHRASMRGGTLLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDEHLYIVVEDDGPGIPLSKREVIFDRGQRVDTLRPGQGVGLAVAREITEQYEGKIVAGESMLGGARMEVIFGRQHSAPKDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10732
Length:	486 (439)
Sequences:	45969 (39821)
Seq/√Len:	1900.6

ECOLI - PHOQ BARA GLRK BAES CREC TORS CUSS CPXA QSEC ENVZ YEDV RSTB ATOS RCSC RCSD ZRAS DCUS NARX DPIB BASS NARQ EVGS ARCB PHOR KDPD YPDA UHPB
BACSU - YCLK CSSS YKOH YYCG RESE YVRG PHOR YVCQ KINB DCTS MALK KIND CITS YRKQ YESM YXDK KINE BCES YCBM KINA KINC GLNK LIAS LYTS YBDK YWPD COMP NATK YDFH
HALSA - Q9HQ15 Q9HQG5 Q9HQ16 Q9HQE9 Q9HR10 O51970 Q9HRE4 Q9HRG1 Q9HNM2 Q9HNA6 BAT Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
414_E	471_R	4.099	1.00
415_D	419_G	4.046	1.00
408_H	475_I	3.835	1.00
450_R	454_E	3.717	1.00
338_H	374_G	3.536	1.00
461_V	473_E	3.408	1.00
412_V	471_R	3.306	1.00
290_L	307_M	3.206	1.00
394_C	416_D	3.130	1.00
401_S	412_V	2.989	1.00
425_R	464_E	2.894	1.00
412_V	473_E	2.859	1.00
363_S	399_E	2.834	1.00
410_Y	475_I	2.824	1.00
363_S	397_F	2.750	1.00
397_F	416_D	2.723	1.00
410_Y	473_E	2.689	1.00
403_R	410_Y	2.667	1.00
374_G	456_Y	2.643	1.00
399_E	414_E	2.636	1.00
337_L	373_V	2.625	1.00
421_P	424_K	2.584	1.00
462_A	472_M	2.580	1.00
287_Q	312_S	2.556	1.00
294_R	308_L	2.538	1.00
365_D	401_S	2.499	1.00
463_G	473_E	2.495	1.00
294_R	305_P	2.493	1.00
449_A	460_I	2.457	1.00
463_G	471_R	2.444	1.00
382_V	453_T	2.438	1.00
465_S	468_G	2.395	1.00
337_L	371_S	2.362	1.00
403_R	412_V	2.361	1.00
401_S	414_E	2.349	1.00
245_R	248_T	2.299	1.00
420_I	428_I	2.265	1.00
429_F	460_I	2.245	1.00
425_R	462_A	2.244	1.00
339_P	342_P	2.233	1.00
424_K	427_V	2.233	1.00
453_T	458_G	2.223	1.00
297_K	300_V	2.221	1.00
464_E	470_A	2.171	1.00
365_D	399_E	2.118	1.00
459_K	475_I	2.111	1.00
346_N	380_V	2.096	1.00
287_Q	311_I	2.070	1.00
453_T	474_V	2.057	1.00
351_L	384_G	2.049	1.00
404_Q	478_R	2.038	1.00
336_E	376_Q	2.006	1.00
405_T	410_Y	1.959	1.00
361_N	397_F	1.958	1.00
427_V	430_D	1.890	1.00
461_V	475_I	1.890	1.00
374_G	379_F	1.869	1.00
422_L	425_R	1.865	1.00
34_M	38_I	1.847	1.00
315_S	319_G	1.841	1.00
270_T	274_D	1.838	1.00
287_Q	315_S	1.835	1.00
382_V	449_A	1.819	1.00
382_V	452_I	1.815	1.00
230_E	235_N	1.811	1.00
335_R	373_V	1.803	1.00
420_I	424_K	1.759	1.00
355_Y	391_C	1.755	1.00
452_I	456_Y	1.747	1.00
383_M	411_I	1.741	1.00
268_Y	272_L	1.741	1.00
247_L	251_V	1.712	1.00
388_D	392_K	1.709	1.00
424_K	433_Q	1.709	1.00
454_E	459_K	1.675	1.00
243_T	248_T	1.674	1.00
420_I	470_A	1.673	1.00
427_V	433_Q	1.664	1.00
294_R	301_S	1.645	1.00
254_L	257_L	1.625	1.00
341_A	345_D	1.620	1.00
424_K	435_V	1.616	1.00
385_N	449_A	1.613	1.00
266_D	270_T	1.612	1.00
225_A	249_S	1.610	1.00
12_S	15_V	1.593	1.00
143_L	146_V	1.581	1.00
375_E	378_D	1.573	1.00
231_L	258_L	1.564	1.00
415_D	469_G	1.561	1.00
291_R	308_L	1.547	1.00
399_E	416_D	1.500	1.00
394_C	398_V	1.494	1.00
290_L	308_L	1.491	1.00
308_L	312_S	1.480	1.00
255_N	258_L	1.477	1.00
411_I	474_V	1.471	1.00
376_Q	380_V	1.467	1.00
293_L	304_E	1.467	1.00
244_T	248_T	1.449	1.00
453_T	460_I	1.447	1.00
429_F	462_A	1.444	1.00
464_E	467_L	1.438	1.00
296_E	300_V	1.437	1.00
289_T	303_A	1.437	1.00
378_D	381_E	1.436	1.00
286_L	311_I	1.420	1.00
225_A	229_R	1.414	1.00
251_V	255_N	1.413	1.00
421_P	466_M	1.410	1.00
464_E	468_G	1.409	1.00
261_E	264_R	1.404	1.00
339_P	371_S	1.399	1.00
354_V	357_R	1.380	1.00
425_R	429_F	1.378	1.00
430_D	433_Q	1.376	1.00
285_V	289_T	1.370	1.00
90_D	94_Q	1.369	1.00
382_V	474_V	1.353	1.00
262_R	265_Y	1.347	1.00
261_E	265_Y	1.345	1.00
451_E	454_E	1.345	1.00
350_A	380_V	1.342	1.00
378_D	455_Q	1.341	1.00
352_N	356_Q	1.326	1.00
348_T	364_L	1.316	1.00
393_Y	434_R	1.315	1.00
260_S	263_E	1.303	1.00
247_L	250_L	1.299	1.00
293_L	300_V	1.273	1.00
290_L	311_I	1.273	1.00
378_D	452_I	1.269	1.00
346_N	376_Q	1.261	1.00
345_D	364_L	1.260	1.00
35_V	39_G	1.259	1.00
341_A	402_A	1.259	1.00
210_L	214_A	1.254	1.00
409_L	478_R	1.246	1.00
285_V	310_Q	1.246	1.00
228_V	231_L	1.243	1.00
287_Q	308_L	1.242	1.00
286_L	307_M	1.239	1.00
278_S	381_E	1.235	1.00
228_V	254_L	1.224	1.00
263_E	267_K	1.223	1.00
193_S	197_Y	1.219	1.00
343_L	347_L	1.216	1.00
458_G	476_F	1.213	1.00
230_E	237_E	1.205	1.00
290_L	294_R	1.205	1.00
271_T	275_L	1.205	1.00
139_I	146_V	1.196	1.00
297_K	301_S	1.192	1.00
428_I	462_A	1.188	1.00
436_D	439_R	1.186	1.00
462_A	470_A	1.177	1.00
248_T	251_V	1.174	1.00
274_D	431_R	1.173	1.00
305_P	309_E	1.171	1.00
408_H	459_K	1.162	1.00
414_E	465_S	1.153	1.00
222_E	225_A	1.152	1.00
41_S	45_D	1.147	1.00
16_R	245_R	1.134	1.00
265_Y	268_Y	1.129	1.00
429_F	450_R	1.129	1.00
189_Y	193_S	1.126	1.00
415_D	470_A	1.118	1.00
429_F	472_M	1.107	1.00
347_L	351_L	1.103	1.00
228_V	253_N	1.095	1.00
228_V	232_E	1.086	1.00
66_E	70_L	1.085	1.00
347_L	384_G	1.078	1.00
289_T	306_V	1.076	1.00
288_S	292_S	1.072	1.00
225_A	253_N	1.067	1.00
316_Q	377_N	1.064	1.00
390_A	398_V	1.059	1.00
254_L	258_L	1.057	1.00
422_L	464_E	1.053	1.00
341_A	366_I	1.050	1.00
156_T	160_A	1.043	1.00
37_L	192_W	1.043	1.00
262_R	266_D	1.041	1.00
385_N	388_D	1.040	1.00
322_L	325_A	1.037	1.00
290_L	304_E	1.032	1.00
319_G	323_H	1.030	1.00
344_L	402_A	1.025	1.00
366_I	402_A	1.023	1.00
238_L	255_N	1.020	1.00
320_Y	378_D	1.020	1.00
405_T	408_H	1.019	1.00
444_V	448_V	1.018	1.00
238_L	258_L	1.016	1.00
338_H	343_L	1.016	1.00
301_S	305_P	1.014	1.00
287_Q	291_R	1.012	1.00
285_V	288_S	1.008	1.00
379_F	456_Y	0.998	1.00
347_L	380_V	0.998	1.00
302_D	306_V	0.997	1.00
335_R	456_Y	0.996	1.00
259_K	263_E	0.991	1.00
217_S	220_P	0.987	1.00
227_E	239_L	0.984	1.00
420_I	425_R	0.982	1.00
348_T	352_N	0.981	1.00
231_L	257_L	0.981	1.00
420_I	462_A	0.980	1.00
207_I	211_W	0.979	1.00
386_V	460_I	0.978	1.00
49_F	53_R	0.977	1.00
260_S	264_R	0.975	1.00
215_W	219_R	0.972	1.00
55_E	58_L	0.972	1.00
214_A	218_L	0.971	1.00
431_R	451_E	0.970	1.00
208_P	212_V	0.967	1.00
383_M	413_V	0.965	1.00
229_R	249_S	0.964	1.00
386_V	472_M	0.963	1.00
253_N	256_R	0.962	1.00
342_P	346_N	0.961	1.00
270_T	431_R	0.956	1.00
280_K	319_G	0.954	1.00
367_S	403_R	0.953	1.00
139_I	143_L	0.952	1.00
351_L	387_L	0.946	1.00
248_T	252_R	0.945	1.00
310_Q	313_R	0.943	1.00
272_L	275_L	0.941	1.00
360_V	394_C	0.940	1.00
380_V	384_G	0.935	1.00
33_G	37_L	0.933	1.00
453_T	476_F	0.932	1.00
405_T	475_I	0.930	1.00
181_I	185_L	0.930	1.00
160_A	163_V	0.926	1.00
38_I	41_S	0.925	1.00
232_E	256_R	0.918	1.00
333_L	375_E	0.917	1.00
306_V	310_Q	0.915	1.00
48_T	51_L	0.912	1.00
316_Q	320_Y	0.910	1.00
56_S	60_Y	0.909	1.00
278_S	385_N	0.909	1.00
428_I	472_M	0.909	1.00
277_H	385_N	0.904	1.00
419_G	470_A	0.904	1.00
386_V	449_A	0.899	1.00
387_L	400_I	0.897	1.00
154_E	158_S	0.894	1.00
384_G	388_D	0.893	1.00
161_V	164_Y	0.892	1.00
212_V	216_W	0.892	1.00
311_I	315_S	0.891	1.00
38_I	42_V	0.891	1.00
350_A	384_G	0.890	1.00
243_T	251_V	0.890	1.00
307_M	311_I	0.889	1.00
347_L	387_L	0.887	1.00
347_L	350_A	0.886	1.00
239_L	255_N	0.886	1.00
449_A	453_T	0.885	1.00
383_M	387_L	0.881	1.00
228_V	250_L	0.878	1.00
360_V	364_L	0.878	1.00
168_S	172_K	0.874	1.00
354_V	388_D	0.873	1.00
173_L	177_V	0.873	1.00
85_M	98_A	0.871	1.00
60_Y	64_K	0.869	1.00
408_H	477_G	0.868	1.00
14_R	215_W	0.867	1.00
51_L	55_E	0.866	1.00
45_D	49_F	0.866	1.00
292_S	296_E	0.865	1.00
343_L	374_G	0.861	1.00
53_R	57_N	0.860	1.00
52_L	56_S	0.860	1.00
393_Y	418_P	0.860	1.00
279_L	314_I	0.859	1.00
340_V	411_I	0.856	1.00
386_V	474_V	0.856	1.00
49_F	52_L	0.856	1.00
228_V	257_L	0.855	1.00
257_L	261_E	0.855	1.00
240_N	255_N	0.852	1.00
227_E	237_E	0.852	1.00
47_T	50_R	0.850	1.00
188_S	192_W	0.850	1.00
284_A	288_S	0.847	1.00
353_K	357_R	0.846	1.00
277_H	281_T	0.846	1.00
229_R	253_N	0.844	1.00
224_L	228_V	0.843	1.00
351_L	388_D	0.842	1.00
239_L	251_V	0.842	1.00
382_V	456_Y	0.836	1.00
258_L	262_R	0.836	1.00
278_S	282_P	0.830	1.00
298_M	301_S	0.829	1.00
86_T	90_D	0.827	1.00
251_V	254_L	0.827	1.00
420_I	426_E	0.826	1.00
377_N	380_V	0.824	1.00
227_E	230_E	0.822	1.00
163_V	166_A	0.821	1.00
302_D	305_P	0.819	1.00
174_T	178_V	0.809	1.00
451_E	455_Q	0.809	1.00
220_P	224_L	0.809	1.00
300_V	303_A	0.808	1.00
345_D	349_S	0.806	1.00
24_V	28_L	0.802	1.00
211_W	215_W	0.798	1.00
158_S	161_V	0.794	1.00
86_T	93_G	0.793	1.00
324_R	447_A	0.791	1.00
47_T	51_L	0.790	1.00
264_R	267_K	0.790	1.00
361_N	364_L	0.789	1.00
250_L	254_L	0.786	1.00
265_Y	269_R	0.785	1.00
193_S	196_I	0.785	1.00
225_A	228_V	0.785	1.00
89_Y	95_L	0.784	1.00
81_Q	84_T	0.782	1.00
314_I	318_I	0.781	1.00
450_R	459_K	0.779	1.00
281_T	285_V	0.779	1.00
420_I	464_E	0.779	1.00
305_P	308_L	0.778	1.00
152_D	156_T	0.778	1.00
66_E	69_K	0.774	1.00
344_L	383_M	0.774	1.00
309_E	346_N	0.774	1.00
349_S	352_N	0.772	1.00
238_L	259_K	0.772	1.00
164_Y	168_S	0.769	1.00
43_S	47_T	0.767	1.00
50_R	53_R	0.766	1.00
229_R	233_E	0.766	1.00
458_G	474_V	0.764	1.00
350_A	354_V	0.764	1.00
158_S	164_Y	0.757	1.00
241_P	248_T	0.756	1.00
37_L	41_S	0.756	1.00
189_Y	192_W	0.756	1.00
345_D	348_T	0.756	1.00
196_I	200_S	0.754	1.00
222_E	226_K	0.753	1.00
289_T	310_Q	0.753	1.00
250_L	253_N	0.753	1.00
306_V	309_E	0.751	1.00
312_S	315_S	0.751	1.00
335_R	374_G	0.748	1.00
159_V	162_N	0.747	1.00
258_L	261_E	0.745	1.00
237_E	240_N	0.744	1.00
334_S	375_E	0.743	1.00
73_E	77_N	0.741	1.00
192_W	196_I	0.739	1.00
56_S	59_F	0.739	1.00
338_H	376_Q	0.739	1.00
425_R	463_G	0.738	1.00
226_K	230_E	0.738	1.00
266_D	269_R	0.736	1.00
158_S	162_N	0.734	1.00
381_E	452_I	0.732	1.00
45_D	48_T	0.730	1.00
333_L	455_Q	0.728	1.00
400_I	413_V	0.726	1.00
159_V	163_V	0.725	1.00
259_K	262_R	0.725	1.00
407_E	478_R	0.724	1.00
448_V	452_I	0.724	1.00
346_N	350_A	0.724	1.00
335_R	457_E	0.723	1.00
245_R	249_S	0.723	1.00
422_L	426_E	0.721	1.00
44_F	47_T	0.721	1.00
39_G	43_S	0.720	1.00
280_K	315_S	0.719	1.00
157_H	161_V	0.718	1.00
154_E	157_H	0.715	1.00
294_R	304_E	0.715	1.00
48_T	52_L	0.713	1.00
289_T	307_M	0.712	1.00
412_V	463_G	0.711	1.00
90_D	96_L	0.710	1.00
415_D	418_P	0.708	1.00
344_L	400_I	0.707	1.00
283_L	318_I	0.707	1.00
190_M	194_W	0.701	1.00
408_H	478_R	0.701	1.00
402_A	411_I	0.701	1.00
353_K	356_Q	0.699	1.00
159_V	164_Y	0.697	1.00
39_G	42_V	0.697	1.00
168_S	171_P	0.695	1.00
303_A	307_M	0.695	1.00
105_L	108_M	0.695	1.00
354_V	358_K	0.694	1.00
359_G	396_E	0.694	1.00
219_R	223_A	0.694	1.00
57_N	61_T	0.691	1.00
52_L	55_E	0.690	1.00
140_Q	143_L	0.686	1.00
275_L	321_Y	0.686	1.00
378_D	382_V	0.686	1.00
160_A	164_Y	0.685	1.00
421_P	435_V	0.684	1.00
267_K	270_T	0.684	1.00
272_L	276_T	0.683	1.00
249_S	252_R	0.683	1.00
142_Q	145_E	0.682	1.00
64_K	68_N	0.682	1.00
264_R	268_Y	0.680	1.00
164_Y	167_T	0.680	1.00
348_T	362_I	0.679	1.00
54_G	57_N	0.678	1.00
278_S	448_V	0.678	1.00
50_R	54_G	0.678	1.00
370_I	402_A	0.677	1.00
349_S	353_K	0.675	1.00
249_S	253_N	0.675	1.00
333_L	378_D	0.674	1.00
355_Y	358_K	0.674	1.00
299_S	303_A	0.674	1.00
30_L	34_M	0.672	1.00
323_H	378_D	0.670	1.00
348_T	351_L	0.670	1.00
142_Q	146_V	0.669	1.00
169_R	172_K	0.669	1.00
284_A	287_Q	0.669	1.00
245_R	251_V	0.668	1.00
434_R	441_G	0.666	1.00
59_F	62_L	0.666	1.00
214_A	217_S	0.665	1.00
340_V	409_L	0.664	1.00
402_A	409_L	0.662	1.00
51_L	54_G	0.662	1.00
285_V	306_V	0.661	1.00
386_V	453_T	0.659	1.00
84_T	87_L	0.659	1.00
378_D	456_Y	0.657	1.00
390_A	413_V	0.657	1.00
320_Y	381_E	0.656	1.00
229_R	232_E	0.655	1.00
322_L	326_S	0.654	1.00
223_A	226_K	0.653	1.00
313_R	380_V	0.652	1.00
269_R	328_R	0.651	1.00
263_E	266_D	0.649	1.00
109_I	114_L	0.648	1.00
46_K	49_F	0.647	1.00
273_T	276_T	0.646	1.00
223_A	227_E	0.643	1.00
422_L	465_S	0.643	1.00
315_S	318_I	0.642	1.00
392_K	441_G	0.642	1.00
424_K	437_T	0.640	1.00
449_A	452_I	0.640	1.00
100_R	103_P	0.639	1.00
42_V	45_D	0.639	1.00
224_L	251_V	0.639	1.00
216_W	219_R	0.639	1.00
355_Y	362_I	0.638	1.00
46_K	50_R	0.636	1.00
323_H	381_E	0.635	1.00
271_T	278_S	0.634	1.00
310_Q	350_A	0.634	1.00
355_Y	398_V	0.634	1.00
153_A	157_H	0.633	1.00
162_N	165_P	0.631	1.00
220_P	245_R	0.630	1.00
360_V	391_C	0.629	1.00
143_L	147_R	0.629	1.00
253_N	257_L	0.628	1.00
221_I	250_L	0.627	1.00
260_S	265_Y	0.626	1.00
461_V	474_V	0.625	1.00
430_D	450_R	0.624	1.00
428_I	447_A	0.623	1.00
279_L	282_P	0.622	1.00
271_T	276_T	0.622	1.00
170_M	173_L	0.622	1.00
341_A	368_P	0.621	1.00
230_E	233_E	0.619	1.00
460_I	472_M	0.619	1.00
165_P	168_S	0.618	1.00
420_I	472_M	0.618	1.00
67_N	70_L	0.617	1.00
106_M	109_I	0.617	1.00
144_Q	147_R	0.617	1.00
155_M	158_S	0.616	1.00
101_D	104_W	0.615	1.00
324_R	431_R	0.614	1.00
61_T	65_W	0.612	1.00
252_R	256_R	0.612	1.00
14_R	222_E	0.611	1.00
304_E	308_L	0.611	1.00
75_P	79_D	0.608	1.00
340_V	372_F	0.606	1.00
220_P	225_A	0.603	1.00
339_P	369_E	0.602	1.00
292_S	303_A	0.600	1.00
243_T	250_L	0.599	1.00
240_N	243_T	0.599	1.00
447_A	451_E	0.598	1.00
435_V	439_R	0.595	1.00
157_H	162_N	0.595	1.00
343_L	379_F	0.593	1.00
365_D	403_R	0.591	1.00
42_V	46_K	0.590	1.00
356_Q	359_G	0.590	1.00
250_L	255_N	0.589	1.00
414_E	467_L	0.589	1.00
221_I	224_L	0.589	1.00
367_S	401_S	0.588	1.00
355_Y	360_V	0.587	1.00
190_M	193_S	0.587	1.00
458_G	477_G	0.586	1.00
57_N	60_Y	0.585	1.00
251_V	258_L	0.584	1.00
34_M	37_L	0.583	1.00
269_R	274_D	0.583	1.00
153_A	156_T	0.582	1.00
410_Y	461_V	0.581	1.00
338_H	373_V	0.580	1.00
62_L	65_W	0.579	1.00
175_I	180_T	0.579	1.00
63_A	66_E	0.579	1.00
227_E	255_N	0.578	1.00
434_R	440_P	0.578	1.00
14_R	18_L	0.578	1.00
230_E	234_H	0.576	1.00
387_L	398_V	0.576	1.00
246_E	251_V	0.576	1.00
83_P	86_T	0.576	1.00
312_S	316_Q	0.575	1.00
426_E	430_D	0.574	1.00
247_L	257_L	0.571	1.00
185_L	189_Y	0.571	1.00
392_K	436_D	0.570	1.00
321_Y	325_A	0.569	1.00
250_L	257_L	0.569	1.00
351_L	391_C	0.569	1.00
367_S	370_I	0.569	1.00
278_S	281_T	0.568	1.00
21_T	210_L	0.568	1.00
425_R	470_A	0.566	1.00
221_I	247_L	0.565	1.00
241_P	251_V	0.564	1.00
259_K	265_Y	0.564	1.00
280_K	314_I	0.564	1.00
90_D	93_G	0.563	1.00
166_A	170_M	0.562	1.00
31_A	35_V	0.562	1.00
206_V	210_L	0.562	1.00
75_P	78_I	0.561	1.00
220_P	228_V	0.561	1.00
274_D	278_S	0.560	1.00
165_P	174_T	0.560	1.00
347_L	354_V	0.560	1.00
351_L	354_V	0.560	1.00
399_E	402_A	0.559	1.00
61_T	64_K	0.559	1.00
93_G	97_W	0.559	1.00
308_L	311_I	0.558	1.00
221_I	225_A	0.557	1.00
23_A	26_L	0.557	1.00
104_W	107_K	0.557	1.00
425_R	472_M	0.556	1.00
341_A	369_E	0.556	1.00
200_S	204_L	0.555	1.00
293_L	303_A	0.555	1.00
20_A	24_V	0.554	1.00
194_W	197_Y	0.553	1.00
355_Y	359_G	0.553	1.00
218_L	222_E	0.552	1.00
345_D	366_I	0.551	1.00
243_T	247_L	0.550	1.00
220_P	243_T	0.550	1.00
236_R	262_R	0.550	1.00
223_A	240_N	0.547	1.00
54_G	58_L	0.547	1.00
155_M	159_V	0.546	1.00
63_A	67_N	0.546	1.00
303_A	306_V	0.546	1.00
278_S	317_Q	0.545	1.00
348_T	400_I	0.545	1.00
107_K	110_Q	0.544	1.00
428_I	433_Q	0.544	1.00
15_V	19_L	0.544	1.00
324_R	451_E	0.542	1.00
156_T	159_V	0.542	1.00
381_E	384_G	0.542	1.00
342_P	345_D	0.541	1.00
16_R	216_W	0.541	1.00
197_Y	201_A	0.541	1.00
269_R	273_T	0.541	1.00
95_L	99_Q	0.540	1.00
58_L	61_T	0.540	1.00
220_P	223_A	0.540	1.00
259_K	264_R	0.539	1.00
398_V	413_V	0.539	1.00
224_L	254_L	0.538	1.00
167_T	170_M	0.538	1.00
56_S	177_V	0.536	1.00
421_P	425_R	0.534	1.00
87_L	95_L	0.531	1.00
140_Q	144_Q	0.530	1.00
390_A	394_C	0.529	1.00
95_L	98_A	0.529	1.00
395_L	416_D	0.529	1.00
43_S	46_K	0.529	1.00
65_W	68_N	0.528	1.00
215_W	222_E	0.528	1.00
76_E	79_D	0.528	1.00
40_Y	43_S	0.528	1.00
314_I	322_L	0.527	1.00
429_F	432_G	0.527	1.00
269_R	272_L	0.526	1.00
19_L	22_A	0.524	1.00
87_L	90_D	0.523	1.00
367_S	402_A	0.522	1.00
161_V	165_P	0.522	1.00
87_L	176_V	0.521	1.00
333_L	456_Y	0.520	1.00
241_P	252_R	0.518	1.00
289_T	293_L	0.517	1.00
358_K	394_C	0.517	1.00
296_E	299_S	0.517	1.00
268_Y	276_T	0.514	1.00
13_L	217_S	0.512	1.00
343_L	350_A	0.511	1.00
82_S	85_M	0.510	1.00
379_F	476_F	0.509	1.00
86_T	98_A	0.508	1.00
395_L	418_P	0.508	1.00
98_A	102_V	0.508	1.00
36_A	195_F	0.507	1.00
276_T	280_K	0.507	1.00
323_H	327_M	0.507	1.00
55_E	59_F	0.507	1.00
59_F	63_A	0.507	1.00
141_Q	144_Q	0.505	1.00
288_S	311_I	0.505	1.00
98_A	101_D	0.503	1.00
180_T	183_V	0.503	1.00
296_E	303_A	0.501	1.00
87_L	98_A	0.501	1.00
236_R	240_N	0.500	1.00
157_H	160_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5453	100	0.381	Contact Map
4bixA	2	0.4691	100	0.387	Contact Map
4ctiA	2	0.4671	100	0.42	Contact Map
4q20A	2	0.463	100	0.47	Contact Map
2q8gA	2	0.6111	100	0.488	Contact Map
4mpcA	2	0.6091	100	0.489	Contact Map
4gczA	2	0.7387	100	0.49	Contact Map
3jz3A	2	0.3189	100	0.495	Contact Map
2c2aA	2	0.4671	100	0.499	Contact Map
2e0aA	2	0.6276	100	0.499	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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