GREMLIN Database
PHOQ - Sensor protein PhoQ
UniProt: P23837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10732
Length: 486 (439)
Sequences: 45969 (39821)
Seq/√Len: 1900.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
414_E471_R4.0991.00
415_D419_G4.0461.00
408_H475_I3.8351.00
450_R454_E3.7171.00
338_H374_G3.5361.00
461_V473_E3.4081.00
412_V471_R3.3061.00
290_L307_M3.2061.00
394_C416_D3.1301.00
401_S412_V2.9891.00
425_R464_E2.8941.00
412_V473_E2.8591.00
363_S399_E2.8341.00
410_Y475_I2.8241.00
363_S397_F2.7501.00
397_F416_D2.7231.00
410_Y473_E2.6891.00
403_R410_Y2.6671.00
374_G456_Y2.6431.00
399_E414_E2.6361.00
337_L373_V2.6251.00
421_P424_K2.5841.00
462_A472_M2.5801.00
287_Q312_S2.5561.00
294_R308_L2.5381.00
365_D401_S2.4991.00
463_G473_E2.4951.00
294_R305_P2.4931.00
449_A460_I2.4571.00
463_G471_R2.4441.00
382_V453_T2.4381.00
465_S468_G2.3951.00
337_L371_S2.3621.00
403_R412_V2.3611.00
401_S414_E2.3491.00
245_R248_T2.2991.00
420_I428_I2.2651.00
429_F460_I2.2451.00
425_R462_A2.2441.00
339_P342_P2.2331.00
424_K427_V2.2331.00
453_T458_G2.2231.00
297_K300_V2.2211.00
464_E470_A2.1711.00
365_D399_E2.1181.00
459_K475_I2.1111.00
346_N380_V2.0961.00
287_Q311_I2.0701.00
453_T474_V2.0571.00
351_L384_G2.0491.00
404_Q478_R2.0381.00
336_E376_Q2.0061.00
405_T410_Y1.9591.00
361_N397_F1.9581.00
427_V430_D1.8901.00
461_V475_I1.8901.00
374_G379_F1.8691.00
422_L425_R1.8651.00
34_M38_I1.8471.00
315_S319_G1.8411.00
270_T274_D1.8381.00
287_Q315_S1.8351.00
382_V449_A1.8191.00
382_V452_I1.8151.00
230_E235_N1.8111.00
335_R373_V1.8031.00
420_I424_K1.7591.00
355_Y391_C1.7551.00
452_I456_Y1.7471.00
383_M411_I1.7411.00
268_Y272_L1.7411.00
247_L251_V1.7121.00
388_D392_K1.7091.00
424_K433_Q1.7091.00
454_E459_K1.6751.00
243_T248_T1.6741.00
420_I470_A1.6731.00
427_V433_Q1.6641.00
294_R301_S1.6451.00
254_L257_L1.6251.00
341_A345_D1.6201.00
424_K435_V1.6161.00
385_N449_A1.6131.00
266_D270_T1.6121.00
225_A249_S1.6101.00
12_S15_V1.5931.00
143_L146_V1.5811.00
375_E378_D1.5731.00
231_L258_L1.5641.00
415_D469_G1.5611.00
291_R308_L1.5471.00
399_E416_D1.5001.00
394_C398_V1.4941.00
290_L308_L1.4911.00
308_L312_S1.4801.00
255_N258_L1.4771.00
411_I474_V1.4711.00
376_Q380_V1.4671.00
293_L304_E1.4671.00
244_T248_T1.4491.00
453_T460_I1.4471.00
429_F462_A1.4441.00
464_E467_L1.4381.00
296_E300_V1.4371.00
289_T303_A1.4371.00
378_D381_E1.4361.00
286_L311_I1.4201.00
225_A229_R1.4141.00
251_V255_N1.4131.00
421_P466_M1.4101.00
464_E468_G1.4091.00
261_E264_R1.4041.00
339_P371_S1.3991.00
354_V357_R1.3801.00
425_R429_F1.3781.00
430_D433_Q1.3761.00
285_V289_T1.3701.00
90_D94_Q1.3691.00
382_V474_V1.3531.00
262_R265_Y1.3471.00
261_E265_Y1.3451.00
451_E454_E1.3451.00
350_A380_V1.3421.00
378_D455_Q1.3411.00
352_N356_Q1.3261.00
348_T364_L1.3161.00
393_Y434_R1.3151.00
260_S263_E1.3031.00
247_L250_L1.2991.00
293_L300_V1.2731.00
290_L311_I1.2731.00
378_D452_I1.2691.00
346_N376_Q1.2611.00
345_D364_L1.2601.00
35_V39_G1.2591.00
341_A402_A1.2591.00
210_L214_A1.2541.00
409_L478_R1.2461.00
285_V310_Q1.2461.00
228_V231_L1.2431.00
287_Q308_L1.2421.00
286_L307_M1.2391.00
278_S381_E1.2351.00
228_V254_L1.2241.00
263_E267_K1.2231.00
193_S197_Y1.2191.00
343_L347_L1.2161.00
458_G476_F1.2131.00
230_E237_E1.2051.00
290_L294_R1.2051.00
271_T275_L1.2051.00
139_I146_V1.1961.00
297_K301_S1.1921.00
428_I462_A1.1881.00
436_D439_R1.1861.00
462_A470_A1.1771.00
248_T251_V1.1741.00
274_D431_R1.1731.00
305_P309_E1.1711.00
408_H459_K1.1621.00
414_E465_S1.1531.00
222_E225_A1.1521.00
41_S45_D1.1471.00
16_R245_R1.1341.00
265_Y268_Y1.1291.00
429_F450_R1.1291.00
189_Y193_S1.1261.00
415_D470_A1.1181.00
429_F472_M1.1071.00
347_L351_L1.1031.00
228_V253_N1.0951.00
228_V232_E1.0861.00
66_E70_L1.0851.00
347_L384_G1.0781.00
289_T306_V1.0761.00
288_S292_S1.0721.00
225_A253_N1.0671.00
316_Q377_N1.0641.00
390_A398_V1.0591.00
254_L258_L1.0571.00
422_L464_E1.0531.00
341_A366_I1.0501.00
156_T160_A1.0431.00
37_L192_W1.0431.00
262_R266_D1.0411.00
385_N388_D1.0401.00
322_L325_A1.0371.00
290_L304_E1.0321.00
319_G323_H1.0301.00
344_L402_A1.0251.00
366_I402_A1.0231.00
238_L255_N1.0201.00
320_Y378_D1.0201.00
405_T408_H1.0191.00
444_V448_V1.0181.00
238_L258_L1.0161.00
338_H343_L1.0161.00
301_S305_P1.0141.00
287_Q291_R1.0121.00
285_V288_S1.0081.00
379_F456_Y0.9981.00
347_L380_V0.9981.00
302_D306_V0.9971.00
335_R456_Y0.9961.00
259_K263_E0.9911.00
217_S220_P0.9871.00
227_E239_L0.9841.00
420_I425_R0.9821.00
348_T352_N0.9811.00
231_L257_L0.9811.00
420_I462_A0.9801.00
207_I211_W0.9791.00
386_V460_I0.9781.00
49_F53_R0.9771.00
260_S264_R0.9751.00
215_W219_R0.9721.00
55_E58_L0.9721.00
214_A218_L0.9711.00
431_R451_E0.9701.00
208_P212_V0.9671.00
383_M413_V0.9651.00
229_R249_S0.9641.00
386_V472_M0.9631.00
253_N256_R0.9621.00
342_P346_N0.9611.00
270_T431_R0.9561.00
280_K319_G0.9541.00
367_S403_R0.9531.00
139_I143_L0.9521.00
351_L387_L0.9461.00
248_T252_R0.9451.00
310_Q313_R0.9431.00
272_L275_L0.9411.00
360_V394_C0.9401.00
380_V384_G0.9351.00
33_G37_L0.9331.00
453_T476_F0.9321.00
405_T475_I0.9301.00
181_I185_L0.9301.00
160_A163_V0.9261.00
38_I41_S0.9251.00
232_E256_R0.9181.00
333_L375_E0.9171.00
306_V310_Q0.9151.00
48_T51_L0.9121.00
316_Q320_Y0.9101.00
56_S60_Y0.9091.00
278_S385_N0.9091.00
428_I472_M0.9091.00
277_H385_N0.9041.00
419_G470_A0.9041.00
386_V449_A0.8991.00
387_L400_I0.8971.00
154_E158_S0.8941.00
384_G388_D0.8931.00
161_V164_Y0.8921.00
212_V216_W0.8921.00
311_I315_S0.8911.00
38_I42_V0.8911.00
350_A384_G0.8901.00
243_T251_V0.8901.00
307_M311_I0.8891.00
347_L387_L0.8871.00
347_L350_A0.8861.00
239_L255_N0.8861.00
449_A453_T0.8851.00
383_M387_L0.8811.00
228_V250_L0.8781.00
360_V364_L0.8781.00
168_S172_K0.8741.00
354_V388_D0.8731.00
173_L177_V0.8731.00
85_M98_A0.8711.00
60_Y64_K0.8691.00
408_H477_G0.8681.00
14_R215_W0.8671.00
51_L55_E0.8661.00
45_D49_F0.8661.00
292_S296_E0.8651.00
343_L374_G0.8611.00
53_R57_N0.8601.00
52_L56_S0.8601.00
393_Y418_P0.8601.00
279_L314_I0.8591.00
340_V411_I0.8561.00
386_V474_V0.8561.00
49_F52_L0.8561.00
228_V257_L0.8551.00
257_L261_E0.8551.00
240_N255_N0.8521.00
227_E237_E0.8521.00
47_T50_R0.8501.00
188_S192_W0.8501.00
284_A288_S0.8471.00
353_K357_R0.8461.00
277_H281_T0.8461.00
229_R253_N0.8441.00
224_L228_V0.8431.00
351_L388_D0.8421.00
239_L251_V0.8421.00
382_V456_Y0.8361.00
258_L262_R0.8361.00
278_S282_P0.8301.00
298_M301_S0.8291.00
86_T90_D0.8271.00
251_V254_L0.8271.00
420_I426_E0.8261.00
377_N380_V0.8241.00
227_E230_E0.8221.00
163_V166_A0.8211.00
302_D305_P0.8191.00
174_T178_V0.8091.00
451_E455_Q0.8091.00
220_P224_L0.8091.00
300_V303_A0.8081.00
345_D349_S0.8061.00
24_V28_L0.8021.00
211_W215_W0.7981.00
158_S161_V0.7941.00
86_T93_G0.7931.00
324_R447_A0.7911.00
47_T51_L0.7901.00
264_R267_K0.7901.00
361_N364_L0.7891.00
250_L254_L0.7861.00
265_Y269_R0.7851.00
193_S196_I0.7851.00
225_A228_V0.7851.00
89_Y95_L0.7841.00
81_Q84_T0.7821.00
314_I318_I0.7811.00
450_R459_K0.7791.00
281_T285_V0.7791.00
420_I464_E0.7791.00
305_P308_L0.7781.00
152_D156_T0.7781.00
66_E69_K0.7741.00
344_L383_M0.7741.00
309_E346_N0.7741.00
349_S352_N0.7721.00
238_L259_K0.7721.00
164_Y168_S0.7691.00
43_S47_T0.7671.00
50_R53_R0.7661.00
229_R233_E0.7661.00
458_G474_V0.7641.00
350_A354_V0.7641.00
158_S164_Y0.7571.00
241_P248_T0.7561.00
37_L41_S0.7561.00
189_Y192_W0.7561.00
345_D348_T0.7561.00
196_I200_S0.7541.00
222_E226_K0.7531.00
289_T310_Q0.7531.00
250_L253_N0.7531.00
306_V309_E0.7511.00
312_S315_S0.7511.00
335_R374_G0.7481.00
159_V162_N0.7471.00
258_L261_E0.7451.00
237_E240_N0.7441.00
334_S375_E0.7431.00
73_E77_N0.7411.00
192_W196_I0.7391.00
56_S59_F0.7391.00
338_H376_Q0.7391.00
425_R463_G0.7381.00
226_K230_E0.7381.00
266_D269_R0.7361.00
158_S162_N0.7341.00
381_E452_I0.7321.00
45_D48_T0.7301.00
333_L455_Q0.7281.00
400_I413_V0.7261.00
159_V163_V0.7251.00
259_K262_R0.7251.00
407_E478_R0.7241.00
448_V452_I0.7241.00
346_N350_A0.7241.00
335_R457_E0.7231.00
245_R249_S0.7231.00
422_L426_E0.7211.00
44_F47_T0.7211.00
39_G43_S0.7201.00
280_K315_S0.7191.00
157_H161_V0.7181.00
154_E157_H0.7151.00
294_R304_E0.7151.00
48_T52_L0.7131.00
289_T307_M0.7121.00
412_V463_G0.7111.00
90_D96_L0.7101.00
415_D418_P0.7081.00
344_L400_I0.7071.00
283_L318_I0.7071.00
190_M194_W0.7011.00
408_H478_R0.7011.00
402_A411_I0.7011.00
353_K356_Q0.6991.00
159_V164_Y0.6971.00
39_G42_V0.6971.00
168_S171_P0.6951.00
303_A307_M0.6951.00
105_L108_M0.6951.00
354_V358_K0.6941.00
359_G396_E0.6941.00
219_R223_A0.6941.00
57_N61_T0.6911.00
52_L55_E0.6901.00
140_Q143_L0.6861.00
275_L321_Y0.6861.00
378_D382_V0.6861.00
160_A164_Y0.6851.00
421_P435_V0.6841.00
267_K270_T0.6841.00
272_L276_T0.6831.00
249_S252_R0.6831.00
142_Q145_E0.6821.00
64_K68_N0.6821.00
264_R268_Y0.6801.00
164_Y167_T0.6801.00
348_T362_I0.6791.00
54_G57_N0.6781.00
278_S448_V0.6781.00
50_R54_G0.6781.00
370_I402_A0.6771.00
349_S353_K0.6751.00
249_S253_N0.6751.00
333_L378_D0.6741.00
355_Y358_K0.6741.00
299_S303_A0.6741.00
30_L34_M0.6721.00
323_H378_D0.6701.00
348_T351_L0.6701.00
142_Q146_V0.6691.00
169_R172_K0.6691.00
284_A287_Q0.6691.00
245_R251_V0.6681.00
434_R441_G0.6661.00
59_F62_L0.6661.00
214_A217_S0.6651.00
340_V409_L0.6641.00
402_A409_L0.6621.00
51_L54_G0.6621.00
285_V306_V0.6611.00
386_V453_T0.6591.00
84_T87_L0.6591.00
378_D456_Y0.6571.00
390_A413_V0.6571.00
320_Y381_E0.6561.00
229_R232_E0.6551.00
322_L326_S0.6541.00
223_A226_K0.6531.00
313_R380_V0.6521.00
269_R328_R0.6511.00
263_E266_D0.6491.00
109_I114_L0.6481.00
46_K49_F0.6471.00
273_T276_T0.6461.00
223_A227_E0.6431.00
422_L465_S0.6431.00
315_S318_I0.6421.00
392_K441_G0.6421.00
424_K437_T0.6401.00
449_A452_I0.6401.00
100_R103_P0.6391.00
42_V45_D0.6391.00
224_L251_V0.6391.00
216_W219_R0.6391.00
355_Y362_I0.6381.00
46_K50_R0.6361.00
323_H381_E0.6351.00
271_T278_S0.6341.00
310_Q350_A0.6341.00
355_Y398_V0.6341.00
153_A157_H0.6331.00
162_N165_P0.6311.00
220_P245_R0.6301.00
360_V391_C0.6291.00
143_L147_R0.6291.00
253_N257_L0.6281.00
221_I250_L0.6271.00
260_S265_Y0.6261.00
461_V474_V0.6251.00
430_D450_R0.6241.00
428_I447_A0.6231.00
279_L282_P0.6221.00
271_T276_T0.6221.00
170_M173_L0.6221.00
341_A368_P0.6211.00
230_E233_E0.6191.00
460_I472_M0.6191.00
165_P168_S0.6181.00
420_I472_M0.6181.00
67_N70_L0.6171.00
106_M109_I0.6171.00
144_Q147_R0.6171.00
155_M158_S0.6161.00
101_D104_W0.6151.00
324_R431_R0.6141.00
61_T65_W0.6121.00
252_R256_R0.6121.00
14_R222_E0.6111.00
304_E308_L0.6111.00
75_P79_D0.6081.00
340_V372_F0.6061.00
220_P225_A0.6031.00
339_P369_E0.6021.00
292_S303_A0.6001.00
243_T250_L0.5991.00
240_N243_T0.5991.00
447_A451_E0.5981.00
435_V439_R0.5951.00
157_H162_N0.5951.00
343_L379_F0.5931.00
365_D403_R0.5911.00
42_V46_K0.5901.00
356_Q359_G0.5901.00
250_L255_N0.5891.00
414_E467_L0.5891.00
221_I224_L0.5891.00
367_S401_S0.5881.00
355_Y360_V0.5871.00
190_M193_S0.5871.00
458_G477_G0.5861.00
57_N60_Y0.5851.00
251_V258_L0.5841.00
34_M37_L0.5831.00
269_R274_D0.5831.00
153_A156_T0.5821.00
410_Y461_V0.5811.00
338_H373_V0.5801.00
62_L65_W0.5791.00
175_I180_T0.5791.00
63_A66_E0.5791.00
227_E255_N0.5781.00
434_R440_P0.5781.00
14_R18_L0.5781.00
230_E234_H0.5761.00
387_L398_V0.5761.00
246_E251_V0.5761.00
83_P86_T0.5761.00
312_S316_Q0.5751.00
426_E430_D0.5741.00
247_L257_L0.5711.00
185_L189_Y0.5711.00
392_K436_D0.5701.00
321_Y325_A0.5691.00
250_L257_L0.5691.00
351_L391_C0.5691.00
367_S370_I0.5691.00
278_S281_T0.5681.00
21_T210_L0.5681.00
425_R470_A0.5661.00
221_I247_L0.5651.00
241_P251_V0.5641.00
259_K265_Y0.5641.00
280_K314_I0.5641.00
90_D93_G0.5631.00
166_A170_M0.5621.00
31_A35_V0.5621.00
206_V210_L0.5621.00
75_P78_I0.5611.00
220_P228_V0.5611.00
274_D278_S0.5601.00
165_P174_T0.5601.00
347_L354_V0.5601.00
351_L354_V0.5601.00
399_E402_A0.5591.00
61_T64_K0.5591.00
93_G97_W0.5591.00
308_L311_I0.5581.00
221_I225_A0.5571.00
23_A26_L0.5571.00
104_W107_K0.5571.00
425_R472_M0.5561.00
341_A369_E0.5561.00
200_S204_L0.5551.00
293_L303_A0.5551.00
20_A24_V0.5541.00
194_W197_Y0.5531.00
355_Y359_G0.5531.00
218_L222_E0.5521.00
345_D366_I0.5511.00
243_T247_L0.5501.00
220_P243_T0.5501.00
236_R262_R0.5501.00
223_A240_N0.5471.00
54_G58_L0.5471.00
155_M159_V0.5461.00
63_A67_N0.5461.00
303_A306_V0.5461.00
278_S317_Q0.5451.00
348_T400_I0.5451.00
107_K110_Q0.5441.00
428_I433_Q0.5441.00
15_V19_L0.5441.00
324_R451_E0.5421.00
156_T159_V0.5421.00
381_E384_G0.5421.00
342_P345_D0.5411.00
16_R216_W0.5411.00
197_Y201_A0.5411.00
269_R273_T0.5411.00
95_L99_Q0.5401.00
58_L61_T0.5401.00
220_P223_A0.5401.00
259_K264_R0.5391.00
398_V413_V0.5391.00
224_L254_L0.5381.00
167_T170_M0.5381.00
56_S177_V0.5361.00
421_P425_R0.5341.00
87_L95_L0.5311.00
140_Q144_Q0.5301.00
390_A394_C0.5291.00
95_L98_A0.5291.00
395_L416_D0.5291.00
43_S46_K0.5291.00
65_W68_N0.5281.00
215_W222_E0.5281.00
76_E79_D0.5281.00
40_Y43_S0.5281.00
314_I322_L0.5271.00
429_F432_G0.5271.00
269_R272_L0.5261.00
19_L22_A0.5241.00
87_L90_D0.5231.00
367_S402_A0.5221.00
161_V165_P0.5221.00
87_L176_V0.5211.00
333_L456_Y0.5201.00
241_P252_R0.5181.00
289_T293_L0.5171.00
358_K394_C0.5171.00
296_E299_S0.5171.00
268_Y276_T0.5141.00
13_L217_S0.5121.00
343_L350_A0.5111.00
82_S85_M0.5101.00
379_F476_F0.5091.00
86_T98_A0.5081.00
395_L418_P0.5081.00
98_A102_V0.5081.00
36_A195_F0.5071.00
276_T280_K0.5071.00
323_H327_M0.5071.00
55_E59_F0.5071.00
59_F63_A0.5071.00
141_Q144_Q0.5051.00
288_S311_I0.5051.00
98_A101_D0.5031.00
180_T183_V0.5031.00
296_E303_A0.5011.00
87_L98_A0.5011.00
236_R240_N0.5001.00
157_H160_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5453 100 0.381 Contact Map
4bixA 2 0.4691 100 0.387 Contact Map
4ctiA 2 0.4671 100 0.42 Contact Map
4q20A 2 0.463 100 0.47 Contact Map
2q8gA 2 0.6111 100 0.488 Contact Map
4mpcA 2 0.6091 100 0.489 Contact Map
4gczA 2 0.7387 100 0.49 Contact Map
3jz3A 2 0.3189 100 0.495 Contact Map
2c2aA 2 0.4671 100 0.499 Contact Map
2e0aA 2 0.6276 100 0.499 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0129 seconds.