GREMLIN Database
PHOP - Transcriptional regulatory protein PhoP
UniProt: P23836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10731
Length: 223 (206)
Sequences: 81998 (58357)
Seq/√Len: 4065.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_R29_D3.8601.00
13_R31_E3.4051.00
17_K29_D3.3651.00
6_V36_A2.8791.00
37_D65_R2.8221.00
34_K56_D2.6221.00
28_D45_P2.5371.00
33_A57_E2.5241.00
41_N69_N2.4171.00
57_E65_R2.3971.00
32_D56_D2.3491.00
30_A39_Y2.1221.00
19_Q105_I2.0741.00
23_A109_M2.0691.00
17_K21_Q2.0261.00
2_R26_Q2.0141.00
53_G81_R1.9551.00
31_E35_E1.9191.00
50_V62_L1.9161.00
188_H191_D1.8941.00
63_I75_I1.8871.00
87_K107_E1.8851.00
39_Y43_H1.8181.00
28_D39_Y1.8111.00
77_V90_V1.7851.00
32_D35_E1.7811.00
28_D43_H1.7721.00
2_R28_D1.7681.00
4_L30_A1.7591.00
65_R69_N1.7581.00
77_V95_A1.7251.00
67_R96_D1.7011.00
64_R93_A1.6731.00
153_F156_T1.6561.00
33_A62_L1.6401.00
84_W104_H1.6291.00
57_E61_S1.6291.00
58_D61_S1.6081.00
97_D111_R1.6071.00
171_K191_D1.5781.00
159_E163_R1.5341.00
39_Y42_E1.5311.00
40_L66_W1.5121.00
65_R68_S1.5061.00
48_A73_L1.4581.00
81_R86_D1.4581.00
20_I112_M1.4561.00
169_V177_Q1.4541.00
63_I77_V1.4451.00
193_L196_R1.4401.00
160_T177_Q1.4391.00
34_K57_E1.4261.00
194_M198_R1.4131.00
170_S173_S1.3791.00
160_T164_N1.3711.00
37_D62_L1.3691.00
61_S64_R1.3691.00
96_D118_R1.3661.00
39_Y45_P1.3361.00
96_D115_L1.3341.00
131_P144_N1.3291.00
47_I112_M1.3181.00
10_A31_E1.3081.00
76_L115_L1.2941.00
52_L60_L1.2911.00
37_D57_E1.2871.00
70_D73_L1.2711.00
7_E13_R1.2621.00
60_L90_V1.2591.00
6_V54_L1.2471.00
25_H113_Q1.2231.00
50_V63_I1.2191.00
38_Y42_E1.2091.00
4_L45_P1.1941.00
89_E93_A1.1931.00
30_A36_A1.1891.00
109_M113_Q1.1751.00
35_E38_Y1.1711.00
35_E39_Y1.1701.00
8_D51_D1.1681.00
52_L77_V1.1631.00
60_L89_E1.1601.00
154_E200_K1.1491.00
83_S86_D1.1441.00
2_R43_H1.1381.00
4_L36_A1.1291.00
34_K38_Y1.1251.00
173_S177_Q1.1181.00
155_Y159_E1.1041.00
84_W88_V1.0921.00
23_A113_Q1.0911.00
4_L39_Y1.0801.00
135_D138_R1.0791.00
110_A114_A1.0711.00
189_T193_L1.0671.00
88_V92_S1.0661.00
140_E147_V1.0651.00
24_G113_Q1.0551.00
36_A62_L1.0521.00
37_D41_N1.0501.00
64_R89_E1.0491.00
107_E110_A1.0461.00
3_V25_H1.0411.00
172_D187_S1.0351.00
203_A212_T1.0341.00
30_A35_E1.0341.00
47_I116_M1.0291.00
156_T159_E1.0261.00
192_V195_G1.0231.00
14_H29_D1.0201.00
92_S113_Q0.9941.00
85_Q89_E0.9931.00
188_H192_V0.9921.00
48_A66_W0.9811.00
5_V16_L0.9801.00
157_I161_L0.9791.00
160_T169_V0.9731.00
36_A40_L0.9721.00
10_A14_H0.9671.00
17_K27_V0.9621.00
87_K100_T0.9581.00
48_A75_I0.9561.00
134_V162_I0.9561.00
6_V30_A0.9521.00
4_L40_L0.9421.00
169_V173_S0.9401.00
11_L15_H0.9391.00
52_L58_D0.9351.00
60_L93_A0.9281.00
84_W87_K0.9261.00
74_P96_D0.9251.00
63_I93_A0.9201.00
50_V77_V0.9171.00
16_L78_L0.9161.00
76_L111_R0.9131.00
38_Y41_N0.9131.00
63_I95_A0.9061.00
14_H17_K0.9051.00
133_Q142_S0.9051.00
50_V75_I0.8971.00
61_S65_R0.8941.00
6_V48_A0.8891.00
89_E92_S0.8851.00
49_I108_V0.8791.00
128_S133_Q0.8681.00
152_A156_T0.8651.00
107_E111_R0.8481.00
136_L159_E0.8431.00
5_V27_V0.8401.00
82_E100_T0.8401.00
52_L86_D0.8371.00
10_A13_R0.8301.00
62_L66_W0.8191.00
18_V22_D0.8181.00
74_P122_L0.8151.00
74_P118_R0.8091.00
115_L118_R0.8071.00
40_L70_D0.8031.00
105_I109_M0.7961.00
64_R68_S0.7931.00
134_V155_Y0.7931.00
25_H109_M0.7921.00
189_T194_M0.7891.00
40_L73_L0.7881.00
52_L81_R0.7861.00
187_S191_D0.7861.00
188_H195_G0.7851.00
86_D89_E0.7831.00
142_S147_V0.7811.00
40_L45_P0.7781.00
54_L62_L0.7761.00
160_T174_L0.7751.00
49_I112_M0.7681.00
12_L103_F0.7671.00
104_H107_E0.7651.00
33_A37_D0.7631.00
103_F108_V0.7621.00
173_S176_L0.7621.00
14_H18_V0.7611.00
192_V196_R0.7601.00
97_D114_A0.7601.00
57_E62_L0.7591.00
6_V62_L0.7551.00
78_L103_F0.7471.00
88_V106_E0.7471.00
172_D176_L0.7441.00
190_I194_M0.7421.00
160_T163_R0.7321.00
16_L108_V0.7311.00
66_W75_I0.7301.00
130_P134_V0.7261.00
203_A208_E0.7251.00
33_A56_D0.7231.00
114_A117_R0.7191.00
204_Q208_E0.7171.00
49_I78_L0.7151.00
196_R199_K0.7141.00
111_R115_L0.7091.00
85_Q106_E0.7081.00
204_Q207_Q0.7081.00
119_N123_A0.7051.00
134_V141_L0.7031.00
53_G80_A0.6981.00
72_S122_L0.6831.00
41_N65_R0.6801.00
195_G199_K0.6781.00
139_R156_T0.6771.00
116_M119_N0.6751.00
44_I70_D0.6731.00
91_L111_R0.6721.00
40_L48_A0.6701.00
37_D40_L0.6681.00
114_A119_N0.6651.00
15_H19_Q0.6631.00
2_R46_D0.6621.00
151_T200_K0.6611.00
33_A54_L0.6611.00
49_I76_L0.6611.00
74_P116_M0.6581.00
199_K202_Q0.6581.00
5_V17_K0.6501.00
106_E110_A0.6481.00
156_T160_T0.6441.00
13_R17_K0.6431.00
67_R74_P0.6431.00
19_Q109_M0.6341.00
202_Q205_Y0.6341.00
9_N80_A0.6321.00
41_N70_D0.6321.00
163_R177_Q0.6301.00
85_Q88_V0.6291.00
60_L86_D0.6281.00
76_L97_D0.6261.00
142_S145_D0.6231.00
90_V95_A0.6231.00
7_E54_L0.6231.00
113_Q117_R0.6221.00
194_M197_L0.6211.00
5_V29_D0.6201.00
66_W71_V0.6201.00
37_D69_N0.6201.00
21_Q27_V0.6181.00
207_Q210_I0.6171.00
9_N12_L0.6171.00
92_S110_A0.6171.00
151_T154_E0.6151.00
202_Q208_E0.6131.00
143_I146_E0.6091.00
207_Q215_G0.6091.00
87_K104_H0.6081.00
171_K187_S0.6081.00
63_I67_R0.6031.00
185_R190_I0.6001.00
103_F107_E0.5961.00
205_Y208_E0.5941.00
131_P135_D0.5931.00
84_W106_E0.5881.00
12_L15_H0.5871.00
163_R169_V0.5871.00
110_A113_Q0.5841.00
208_E211_T0.5841.00
158_M161_L0.5791.00
198_R203_A0.5751.00
74_P119_N0.5721.00
161_L164_N0.5641.00
135_D140_E0.5641.00
186_E189_T0.5641.00
139_R155_Y0.5631.00
67_R73_L0.5581.00
19_Q23_A0.5571.00
50_V54_L0.5511.00
52_L90_V0.5481.00
3_V47_I0.5471.00
20_I25_H0.5461.00
66_W73_L0.5441.00
51_D101_K0.5441.00
80_A102_P0.5421.00
193_L197_L0.5421.00
79_T87_K0.5411.00
164_N177_Q0.5391.00
118_R122_L0.5381.00
88_V91_L0.5381.00
5_V13_R0.5371.00
195_G198_R0.5351.00
50_V66_W0.5351.00
191_D194_M0.5341.00
72_S121_G0.5341.00
151_T161_L0.5311.00
35_E56_D0.5301.00
111_R114_A0.5301.00
3_V20_I0.5291.00
74_P115_L0.5291.00
185_R189_T0.5251.00
114_A118_R0.5211.00
8_D79_T0.5211.00
134_V159_E0.5171.00
130_P133_Q0.5161.00
207_Q211_T0.5161.00
204_Q209_V0.5151.00
189_T196_R0.5131.00
161_L194_M0.5121.00
32_D54_L0.5091.00
40_L62_L0.5081.00
6_V33_A0.5081.00
211_T214_R0.5071.00
82_E102_P0.5071.00
136_L139_R0.5061.00
79_T101_K0.5061.00
18_V21_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.9865 100 0.19 Contact Map
3r0jA 2 0.9776 100 0.191 Contact Map
1ys7A 2 0.9955 100 0.193 Contact Map
1kgsA 1 0.9776 100 0.198 Contact Map
4kfcA 2 0.9865 100 0.209 Contact Map
4b09A 2 0.9327 100 0.217 Contact Map
2oqrA 2 0.9865 100 0.218 Contact Map
2hqrA 2 0.9686 100 0.219 Contact Map
1p2fA 1 0.9596 100 0.242 Contact Map
3q9sA 1 0.9372 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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