GREMLIN Database
PSS - CDP-diacylglycerol--serine O-phosphatidyltransferase
UniProt: P23830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10781
Length: 451 (415)
Sequences: 577 (401)
Seq/√Len: 19.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_K78_R6.8661.00
41_L70_A6.7071.00
71_L83_V5.1051.00
309_P317_I4.2581.00
50_R181_D4.1221.00
183_M386_N3.9681.00
142_F151_S3.8691.00
214_D218_F3.8441.00
218_F222_L3.8051.00
148_V180_S3.5691.00
62_D157_D3.2611.00
237_Q394_Q3.0450.99
395_L398_A2.7430.98
55_A142_F2.7070.98
28_D175_R2.6950.98
177_R181_D2.6770.98
61_D64_G2.6110.98
129_N317_I2.5840.98
108_W112_M2.5180.97
144_I149_L2.5050.97
43_K147_S2.4800.97
250_S253_N2.3890.96
240_V388_I2.3800.96
214_D222_L2.3800.96
31_Y403_K2.3590.96
174_I240_V2.3580.96
43_K144_I2.3060.95
39_T43_K2.3000.95
23_S26_D2.2860.95
269_I276_L2.2590.95
362_W368_M2.1810.94
114_Q117_P2.1570.93
29_F400_Q2.1430.93
24_V394_Q2.1240.93
400_Q437_R2.0820.92
351_D411_H2.0750.92
257_F283_N2.0750.92
22_Q27_V2.0660.92
260_M280_L2.0490.92
426_D432_R2.0470.91
24_V237_Q2.0400.91
49_Q181_D1.9190.89
150_Y388_I1.8880.88
30_F173_L1.8610.87
215_I222_L1.8150.86
129_N362_W1.8120.85
40_L144_I1.8100.85
326_I330_R1.8030.85
52_C143_I1.7850.85
146_D177_R1.7510.83
82_D188_T1.7500.83
63_G155_L1.7500.83
277_P349_W1.7440.83
370_I384_L1.7430.83
143_I356_Y1.7430.83
274_F331_F1.7340.83
71_L282_R1.7130.82
36_F142_F1.7050.82
54_V58_L1.7040.82
28_D400_Q1.6990.81
149_L173_L1.6750.80
18_P155_L1.6740.80
60_Q65_K1.6640.80
26_D175_R1.6370.79
347_R409_R1.6330.79
52_C187_V1.6290.79
33_P285_I1.6200.78
35_D148_V1.6040.77
71_L85_V1.5990.77
174_I267_L1.5960.77
308_I318_G1.5860.77
246_L386_N1.5700.76
285_I288_L1.5470.75
192_M396_E1.5440.75
136_V272_P1.5310.74
349_W382_L1.5210.73
144_I260_M1.5130.73
30_F227_Y1.5100.73
131_R272_P1.5070.73
297_I361_M1.4920.72
153_A159_Y1.4720.71
315_K362_W1.4690.71
129_N315_K1.4670.71
38_E356_Y1.4420.69
115_E119_V1.4400.69
408_I412_T1.4350.69
179_M183_M1.4300.69
64_G349_W1.4120.68
374_N385_E1.4080.67
369_L389_L1.3880.66
29_F260_M1.3880.66
179_M242_P1.3860.66
52_C184_F1.3710.65
36_F248_K1.3690.65
210_E218_F1.3660.65
238_L392_D1.3630.65
183_M388_I1.3620.65
245_G300_D1.3530.64
168_Y354_N1.3410.64
333_S408_I1.3390.63
29_F266_K1.3320.63
42_E46_S1.3210.62
378_R385_E1.3180.62
400_Q403_K1.3180.62
34_A38_E1.3180.62
214_D221_E1.3080.62
219_R222_L1.3010.61
23_S338_Y1.3010.61
374_N383_D1.2890.60
32_A35_D1.2870.60
332_L346_V1.2840.60
349_W376_N1.2790.60
214_D219_R1.2700.59
58_L155_L1.2560.58
274_F349_W1.2550.58
178_K181_D1.2540.58
50_R184_F1.2480.58
52_C84_R1.2460.58
102_S108_W1.2450.58
349_W387_A1.2440.58
74_A77_Q1.2380.57
44_I71_L1.2350.57
41_L356_Y1.2320.57
432_R435_I1.2260.56
302_T307_Y1.2250.56
76_R111_R1.2230.56
295_E409_R1.2130.56
211_I214_D1.2120.56
59_E96_R1.2040.55
227_Y344_L1.2020.55
378_R383_D1.1810.54
141_G148_V1.1800.54
33_P37_R1.1790.53
242_P276_L1.1760.53
90_H358_L1.1750.53
298_V307_Y1.1730.53
428_P432_R1.1730.53
99_A103_N1.1720.53
280_L379_A1.1700.53
228_H232_D1.1690.53
159_Y167_R1.1670.53
271_T376_N1.1660.53
27_V44_I1.1620.52
175_R415_V1.1620.52
45_A71_L1.1610.52
210_E214_D1.1600.52
226_A293_K1.1530.52
226_A234_D1.1510.52
37_R356_Y1.1410.51
12_Q15_A1.1380.51
137_L358_L1.1370.51
90_H93_Q1.1350.51
54_V187_V1.1300.50
211_I222_L1.1240.50
281_V334_R1.1240.50
131_R356_Y1.1230.50
302_T355_T1.1230.50
119_V365_D1.1180.50
37_R419_R1.1180.50
425_A429_V1.1180.50
136_V246_L1.1160.49
405_L409_R1.1140.49
243_L390_I1.1090.49
226_A403_K1.1080.49
84_R184_F1.1080.49
116_N137_L1.1070.49
305_D308_I1.0970.48
27_V33_P1.0970.48
211_I215_I1.0930.48
99_A149_L1.0910.48
115_E123_V1.0870.48
28_D367_W1.0840.47
45_A330_R1.0800.47
80_E403_K1.0720.47
74_A78_R1.0700.46
172_H401_R1.0680.46
37_R144_I1.0680.46
209_P215_I1.0610.46
377_P380_W1.0560.46
373_N384_L1.0560.46
246_L380_W1.0530.45
69_N201_D1.0470.45
148_V183_M1.0440.45
153_A167_R1.0430.45
45_A70_A1.0420.45
53_I332_L1.0410.45
160_L182_I1.0380.44
243_L274_F1.0380.44
268_T297_I1.0370.44
145_D152_G1.0300.44
336_Q342_D1.0290.44
345_V414_I1.0280.44
294_V319_A1.0280.44
136_V376_N1.0270.44
129_N309_P1.0240.44
81_L303_A1.0200.43
168_Y407_L1.0160.43
361_M416_K1.0160.43
136_V139_F1.0080.43
54_V67_I1.0060.42
270_C331_F1.0040.42
33_P54_V1.0030.42
152_G324_Y1.0010.42
366_K391_H1.0000.42
328_L346_V0.9930.42
168_Y387_A0.9930.42
320_L363_V0.9930.42
295_E347_R0.9920.42
30_F403_K0.9890.41
336_Q340_N0.9870.41
69_N230_Q0.9840.41
176_N218_F0.9820.41
276_L320_L0.9800.41
177_R232_D0.9790.41
259_L262_C0.9790.41
21_S27_V0.9790.41
43_K149_L0.9740.40
77_Q226_A0.9730.40
149_L326_I0.9710.40
256_I300_D0.9690.40
382_L387_A0.9650.40
376_N380_W0.9590.39
64_G270_C0.9590.39
325_E428_P0.9560.39
297_I412_T0.9560.39
89_W129_N0.9550.39
272_P299_G0.9530.39
40_L149_L0.9520.39
194_G223_R0.9500.39
376_N387_A0.9450.39
255_T370_I0.9430.38
269_I361_M0.9430.38
58_L95_G0.9410.38
210_E213_N0.9400.38
138_H145_D0.9340.38
140_K145_D0.9340.38
211_I333_S0.9340.38
41_L45_A0.9330.38
21_S237_Q0.9280.38
397_L404_E0.9270.38
338_Y346_V0.9260.37
374_N378_R0.9260.37
305_D318_G0.9220.37
76_R234_D0.9210.37
44_I47_A0.9120.37
253_N256_I0.9120.37
187_V191_I0.9050.36
174_I388_I0.9030.36
29_F338_Y0.9010.36
36_F144_I0.8990.36
229_F434_L0.8960.36
302_T350_K0.8950.36
58_L85_V0.8940.36
301_K351_D0.8920.35
53_I185_E0.8870.35
305_D328_L0.8840.35
188_T402_E0.8810.35
376_N382_L0.8800.35
213_N216_R0.8780.35
106_A320_L0.8740.34
48_K73_E0.8740.34
416_K419_R0.8740.34
119_V134_L0.8740.34
156_N186_W0.8730.34
340_N343_Q0.8720.34
128_I136_V0.8690.34
198_N402_E0.8690.34
218_F221_E0.8670.34
89_W362_W0.8640.34
297_I405_L0.8610.34
73_E83_V0.8580.33
34_A69_N0.8570.33
92_A275_N0.8560.33
426_D436_R0.8540.33
356_Y377_P0.8530.33
153_A169_D0.8530.33
197_V225_A0.8490.33
35_D232_D0.8480.33
18_P119_V0.8440.33
17_L87_V0.8440.33
271_T317_I0.8410.32
299_G325_E0.8370.32
370_I373_N0.8360.32
86_L187_V0.8340.32
207_K230_Q0.8320.32
86_L362_W0.8320.32
260_M267_L0.8300.32
62_D355_T0.8280.32
179_M222_L0.8280.32
47_A56_L0.8280.32
108_W373_N0.8270.32
178_K233_A0.8260.32
140_K152_G0.8240.32
138_H152_G0.8240.32
133_A143_I0.8230.31
92_A131_R0.8230.31
54_V373_N0.8220.31
83_V181_D0.8210.31
139_F358_L0.8200.31
59_E372_G0.8180.31
32_A407_L0.8170.31
68_L292_K0.8160.31
262_C296_I0.8150.31
276_L296_I0.8110.31
33_P103_N0.8070.31
202_D209_P0.8040.30
69_N235_N0.8030.30
25_D48_K0.8010.30
213_N228_H0.8000.30
137_L323_L0.7990.30
54_V173_L0.7980.30
66_G74_A0.7940.30
411_H414_I0.7900.30
95_G143_I0.7900.30
116_N123_V0.7870.30
142_F272_P0.7830.29
301_K354_N0.7820.29
71_L97_I0.7810.29
78_R256_I0.7800.29
79_P349_W0.7790.29
316_I362_W0.7790.29
129_N133_A0.7760.29
53_I155_L0.7680.29
52_C270_C0.7670.28
270_C362_W0.7670.28
195_R309_P0.7660.28
92_A284_I0.7660.28
26_D346_V0.7660.28
58_L361_M0.7640.28
27_V32_A0.7640.28
177_R341_T0.7630.28
320_L377_P0.7630.28
270_C358_L0.7560.28
398_A405_L0.7550.28
128_I377_P0.7540.28
330_R355_T0.7540.28
19_K400_Q0.7540.28
73_E85_V0.7520.28
263_A296_I0.7490.28
237_Q397_L0.7490.28
102_S149_L0.7460.27
45_A73_E0.7450.27
103_N108_W0.7450.27
20_I182_I0.7440.27
334_R370_I0.7440.27
89_W240_V0.7430.27
130_T316_I0.7420.27
270_C356_Y0.7400.27
243_L389_L0.7390.27
52_C349_W0.7380.27
51_I412_T0.7360.27
271_T309_P0.7340.27
117_P370_I0.7330.27
168_Y401_R0.7320.27
392_D397_L0.7320.27
117_P362_W0.7320.27
45_A48_K0.7320.27
104_T136_V0.7310.27
196_G200_L0.7310.27
48_K178_K0.7300.27
176_N231_G0.7300.27
134_L276_L0.7300.27
275_N298_V0.7300.27
20_I229_F0.7290.27
33_P373_N0.7290.27
408_I432_R0.7280.26
300_D317_I0.7270.26
297_I408_I0.7270.26
100_A103_N0.7260.26
209_P214_D0.7230.26
354_N433_K0.7230.26
407_L410_E0.7220.26
301_K348_L0.7210.26
55_A87_V0.7210.26
54_V319_A0.7170.26
238_L394_Q0.7170.26
351_D355_T0.7160.26
126_V130_T0.7140.26
77_Q410_E0.7140.26
399_P413_T0.7130.26
36_F151_S0.7110.26
95_G158_V0.7070.25
231_G260_M0.7050.25
69_N77_Q0.7020.25
24_V240_V0.6980.25
133_A271_T0.6970.25
156_N160_L0.6970.25
271_T319_A0.6970.25
197_V259_L0.6960.25
129_N405_L0.6960.25
95_G128_I0.6920.25
238_L396_E0.6900.25
106_A347_R0.6880.25
93_Q309_P0.6880.25
371_T392_D0.6880.25
92_A141_G0.6860.24
213_N399_P0.6860.24
86_L191_I0.6860.24
35_D177_R0.6850.24
168_Y246_L0.6840.24
28_D403_K0.6830.24
29_F50_R0.6780.24
30_F78_R0.6760.24
232_D396_E0.6760.24
119_V315_K0.6760.24
55_A172_H0.6740.24
48_K80_E0.6710.24
36_F218_F0.6710.24
92_A272_P0.6700.24
317_I354_N0.6700.24
205_R208_S0.6700.24
246_L376_N0.6690.24
22_Q176_N0.6690.24
60_Q64_G0.6660.23
247_G369_L0.6650.23
268_T409_R0.6650.23
93_Q317_I0.6640.23
144_I155_L0.6620.23
92_A305_D0.6610.23
201_D217_L0.6610.23
290_E415_V0.6600.23
12_Q103_N0.6590.23
43_K126_V0.6580.23
76_R289_R0.6580.23
422_Q427_Y0.6560.23
148_V282_R0.6530.23
184_F188_T0.6530.23
176_N271_T0.6520.23
98_G227_Y0.6500.23
28_D390_I0.6440.22
69_N73_E0.6440.22
115_E195_R0.6440.22
246_L277_P0.6430.22
251_L267_L0.6430.22
267_L352_D0.6430.22
188_T337_Y0.6420.22
86_L173_L0.6420.22
137_L384_L0.6410.22
185_E188_T0.6410.22
276_L280_L0.6370.22
358_L379_A0.6370.22
28_D39_T0.6360.22
20_I236_D0.6350.22
21_S36_F0.6320.22
160_L379_A0.6310.22
68_L382_L0.6310.22
310_E320_L0.6310.22
54_V283_N0.6290.22
247_G271_T0.6290.22
245_G305_D0.6270.22
268_T275_N0.6270.22
319_A382_L0.6260.22
211_I219_R0.6260.22
60_Q409_R0.6250.22
65_K146_D0.6250.22
372_G379_A0.6250.22
154_S158_V0.6240.22
90_H136_V0.6240.22
22_Q413_T0.6230.22
216_R264_E0.6200.21
305_D351_D0.6180.21
271_T300_D0.6160.21
205_R297_I0.6160.21
21_S239_S0.6140.21
71_L125_G0.6140.21
134_L335_L0.6140.21
271_T377_P0.6130.21
116_N119_V0.6110.21
261_P283_N0.6090.21
63_G160_L0.6080.21
214_D223_R0.6070.21
85_V289_R0.6060.21
43_K173_L0.6050.21
53_I256_I0.6050.21
360_G374_N0.6030.21
167_R170_R0.6020.21
39_T42_E0.6020.21
85_V302_T0.6010.21
116_N136_V0.5990.21
103_N120_D0.5990.21
294_V352_D0.5980.20
340_N368_M0.5980.20
367_W393_P0.5980.20
190_N265_Q0.5980.20
159_Y170_R0.5970.20
126_V322_Y0.5970.20
178_K405_L0.5960.20
147_S174_I0.5950.20
34_A249_S0.5950.20
63_G349_W0.5940.20
28_D394_Q0.5930.20
416_K420_D0.5930.20
29_F37_R0.5910.20
187_V218_F0.5910.20
215_I219_R0.5900.20
95_G388_I0.5900.20
250_S254_K0.5890.20
35_D181_D0.5890.20
42_E69_N0.5880.20
43_K54_V0.5880.20
133_A270_C0.5870.20
280_L387_A0.5860.20
260_M384_L0.5860.20
168_Y272_P0.5850.20
263_A292_K0.5850.20
156_N376_N0.5840.20
51_I83_V0.5830.20
253_N328_L0.5830.20
277_P344_L0.5800.20
69_N177_R0.5800.20
336_Q417_H0.5800.20
253_N305_D0.5790.20
202_D244_V0.5790.20
198_N338_Y0.5790.20
192_M260_M0.5790.20
73_E258_H0.5750.20
77_Q345_V0.5740.19
139_F240_V0.5740.19
60_Q108_W0.5720.19
119_V355_T0.5720.19
372_G385_E0.5720.19
130_T436_R0.5710.19
82_D184_F0.5710.19
179_M368_M0.5700.19
22_Q186_W0.5700.19
34_A345_V0.5680.19
62_D174_I0.5680.19
105_N372_G0.5680.19
27_V86_L0.5680.19
220_Q223_R0.5670.19
297_I362_W0.5670.19
156_N375_L0.5670.19
229_F233_A0.5660.19
59_E191_I0.5650.19
30_F174_I0.5650.19
28_D76_R0.5640.19
179_M399_P0.5620.19
30_F46_S0.5610.19
59_E154_S0.5600.19
174_I302_T0.5600.19
61_D157_D0.5600.19
242_P274_F0.5590.19
134_L384_L0.5560.19
266_K293_K0.5560.19
46_S293_K0.5540.19
149_L220_Q0.5540.19
208_S297_I0.5530.19
22_Q240_V0.5520.19
44_I79_P0.5520.19
12_Q205_R0.5510.19
41_L66_G0.5500.19
263_A363_V0.5490.18
284_I296_I0.5490.18
310_E422_Q0.5470.18
26_D228_H0.5470.18
30_F66_G0.5470.18
171_Y331_F0.5460.18
300_D319_A0.5460.18
196_G427_Y0.5450.18
90_H356_Y0.5440.18
275_N380_W0.5440.18
175_R267_L0.5440.18
148_V177_R0.5430.18
33_P36_F0.5410.18
271_T275_N0.5410.18
47_A227_Y0.5410.18
49_Q395_L0.5410.18
67_I83_V0.5390.18
37_R63_G0.5370.18
219_R223_R0.5340.18
226_A264_E0.5330.18
45_A85_V0.5330.18
73_E232_D0.5310.18
176_N269_I0.5310.18
55_A363_V0.5310.18
360_G385_E0.5290.18
129_N295_E0.5290.18
424_I427_Y0.5260.18
432_R436_R0.5250.18
43_K86_L0.5250.18
90_H317_I0.5250.18
51_I416_K0.5250.18
333_S361_M0.5240.18
132_E273_Y0.5240.18
273_Y357_H0.5240.18
132_E359_K0.5240.18
273_Y359_K0.5240.18
132_E357_H0.5240.18
37_R40_L0.5240.18
50_R135_G0.5220.17
289_R316_I0.5220.17
242_P331_F0.5220.17
54_V363_V0.5220.17
33_P426_D0.5210.17
103_N112_M0.5200.17
133_A151_S0.5200.17
67_I272_P0.5200.17
427_Y433_K0.5190.17
54_V111_R0.5180.17
263_A267_L0.5150.17
368_M430_K0.5150.17
33_P59_E0.5140.17
375_L386_N0.5120.17
336_Q389_L0.5110.17
299_G305_D0.5100.17
236_D406_E0.5080.17
182_I398_A0.5080.17
20_I67_I0.5080.17
52_C267_L0.5080.17
45_A230_Q0.5080.17
392_D404_E0.5080.17
385_E404_E0.5060.17
272_P325_E0.5050.17
28_D45_A0.5050.17
230_Q240_V0.5050.17
49_Q124_Y0.5050.17
97_I139_F0.5030.17
315_K354_N0.5020.17
154_S348_L0.5020.17
213_N368_M0.5010.17
117_P397_L0.5010.17
179_M329_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hsiA 2 0.9911 100 0.587 Contact Map
1v0wA 1 0.8692 100 0.81 Contact Map
2o8rA 2 0.7716 99.8 0.874 Contact Map
1xdpA 4 0.7694 99.8 0.874 Contact Map
4ggjA 2 0.3392 99.4 0.908 Contact Map
1byrA 2 0.3304 99.4 0.908 Contact Map
4gelA 2 0.3636 99.3 0.914 Contact Map
4urjA 1 0.357 99.3 0.914 Contact Map
2c1lA 2 0.4169 98.6 0.934 Contact Map
4rctA 2 0.4213 98.5 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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