GREMLIN Database
ECOT - Ecotin
UniProt: P23827 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10255
Length: 162 (146)
Sequences: 253 (173)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_C107_C4.4041.00
94_F119_A3.7090.99
139_T145_V3.5430.99
63_G116_F3.3440.99
74_R101_V2.9870.97
53_E131_S2.9360.97
60_L137_V2.5030.93
58_V135_I2.4630.92
67_E112_K2.1620.86
86_G89_Y2.0950.84
43_Q139_T2.0920.84
50_Q56_L2.0530.83
49_P149_V2.0310.82
81_N90_D2.0260.82
15_T21_A1.9550.80
71_N105_M1.9170.78
13_F16_T1.8910.77
82_K85_E1.8500.76
26_P29_K1.7540.72
75_L81_N1.7530.72
47_L53_E1.6880.69
32_P42_R1.6830.68
45_I135_I1.6690.68
92_Y127_L1.6490.67
52_D55_T1.5530.62
36_A104_M1.5440.61
74_R102_S1.5160.60
41_K141_D1.5080.60
19_W22_E1.4920.59
43_Q159_A1.4650.57
116_F146_K1.4530.57
109_D112_K1.4060.54
31_A84_L1.4010.54
87_W133_L1.3840.53
33_Y151_K1.3780.53
93_V125_G1.3720.52
68_V73_H1.3460.51
71_N103_T1.3230.50
70_C91_Y1.3120.49
91_Y107_C1.3020.48
15_T22_E1.2570.46
40_M146_K1.2550.46
77_G94_F1.2520.46
60_L150_W1.2440.45
131_S150_W1.2370.45
35_Q111_K1.2200.44
86_G138_Y1.1980.43
41_K142_N1.1910.42
35_Q141_D1.1870.42
65_T144_D1.1800.42
86_G91_Y1.1660.41
153_E156_I1.1570.41
85_E111_K1.1390.40
135_I158_N1.1360.39
72_L137_V1.1070.38
19_W117_V1.1040.38
13_F17_S1.0920.37
56_L143_V1.0860.37
33_Y55_T1.0790.37
62_I145_V1.0770.36
118_T127_L1.0730.36
47_L56_L1.0720.36
59_E131_S1.0650.36
59_E89_Y1.0540.35
59_E87_W1.0470.35
84_L146_K1.0350.34
95_D143_V1.0270.34
39_G50_Q1.0220.34
54_S141_D1.0100.33
38_K59_E1.0000.33
15_T19_W1.0000.33
53_E145_V0.9990.33
36_A145_V0.9970.32
42_R61_L0.9970.32
82_K132_K0.9810.32
52_D90_D0.9810.32
42_R137_V0.9800.32
12_A15_T0.9680.31
16_T22_E0.9660.31
124_A146_K0.9610.31
42_R150_W0.9600.31
41_K95_D0.9570.31
74_R98_S0.9570.31
62_I65_T0.9570.31
125_G146_K0.9540.30
104_M112_K0.9480.30
97_V119_A0.9480.30
67_E141_D0.9450.30
72_L101_V0.9400.30
44_V137_V0.9340.29
12_A16_T0.9190.29
94_F97_V0.9130.29
124_A127_L0.9070.28
130_N135_I0.9050.28
27_L30_I0.9030.28
84_L95_D0.8960.28
90_D146_K0.8890.27
144_D159_A0.8880.27
50_Q131_S0.8870.27
39_G63_G0.8840.27
79_L152_A0.8820.27
148_R152_A0.8800.27
93_V139_T0.8730.27
97_V100_P0.8720.27
62_I124_A0.8710.27
28_E31_A0.8710.27
60_L127_L0.8690.27
75_L95_D0.8660.26
53_E65_T0.8620.26
86_G133_L0.8610.26
97_V132_K0.8600.26
47_L131_S0.8330.25
65_T114_K0.8310.25
62_I125_G0.8300.25
89_Y133_L0.8280.25
15_T20_A0.8250.25
30_I84_L0.8250.25
36_A147_Y0.8220.25
52_D109_D0.8120.24
58_V61_L0.8050.24
53_E59_E0.7830.23
111_K115_K0.7800.23
83_T123_D0.7770.23
142_N155_K0.7730.23
51_E79_L0.7680.23
87_W91_Y0.7640.22
146_K158_N0.7640.22
27_L31_A0.7610.22
67_E114_K0.7590.22
75_L94_F0.7390.21
24_V61_L0.7380.21
84_L107_C0.7370.21
37_E80_E0.7230.21
93_V127_L0.7210.21
90_D93_V0.7170.21
13_F19_W0.7130.20
48_T57_K0.7130.20
16_T49_P0.7120.20
108_P117_V0.7070.20
79_L94_F0.7030.20
99_S151_K0.7010.20
17_S20_A0.7010.20
59_E77_G0.6980.20
51_E112_K0.6960.20
87_W93_V0.6930.20
15_T154_E0.6880.20
71_N107_C0.6860.20
81_N132_K0.6780.19
32_P87_W0.6700.19
57_K68_V0.6570.19
55_T154_E0.6570.19
68_V115_K0.6560.19
34_P86_G0.6550.18
61_L150_W0.6450.18
51_E73_H0.6420.18
20_A40_M0.6420.18
119_A122_G0.6410.18
100_P122_G0.6400.18
131_S147_Y0.6390.18
92_Y98_S0.6370.18
85_E110_G0.6350.18
43_Q53_E0.6350.18
48_T106_A0.6320.18
62_I75_L0.6300.18
31_A45_I0.6230.17
103_T106_A0.6220.17
56_L102_S0.6190.17
70_C102_S0.6170.17
83_T87_W0.6130.17
27_L84_L0.6080.17
15_T33_Y0.6000.17
39_G141_D0.5980.17
70_C84_L0.5920.16
29_K104_M0.5880.16
46_Q111_K0.5870.16
43_Q66_L0.5860.16
15_T18_A0.5810.16
94_F143_V0.5800.16
50_Q53_E0.5780.16
75_L122_G0.5780.16
82_K104_M0.5780.16
14_A22_E0.5710.16
132_K142_N0.5700.16
64_Q109_D0.5670.16
63_G77_G0.5620.16
131_S148_R0.5620.16
18_A23_S0.5600.16
84_L88_G0.5600.16
80_E85_E0.5550.15
16_T139_T0.5530.15
114_K148_R0.5490.15
28_E56_L0.5490.15
51_E55_T0.5480.15
84_L111_K0.5450.15
89_Y138_Y0.5450.15
115_K146_K0.5410.15
76_G113_E0.5340.15
83_T91_Y0.5320.15
17_S154_E0.5290.15
22_E128_R0.5270.15
94_F100_P0.5250.15
85_E154_E0.5220.14
46_Q78_K0.5220.14
19_W144_D0.5220.14
55_T157_D0.5220.14
89_Y132_K0.5130.14
106_A133_L0.5120.14
12_A20_A0.5110.14
71_N106_A0.5110.14
58_V131_S0.5110.14
14_A149_V0.5100.14
13_F22_E0.5070.14
114_K151_K0.5050.14
79_L119_A0.5040.14
69_D103_T0.5030.14
46_Q95_D0.5030.14
36_A109_D0.5030.14
138_Y147_Y0.5010.14
66_L91_Y0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sluA 2 0.8086 100 0.139 Contact Map
2y6tE 2 0.8704 100 0.148 Contact Map
2la7A 1 0.7593 92.6 0.914 Contact Map
2ktsA 1 0.7037 91.9 0.916 Contact Map
3zbiC 1 0.1728 13.1 0.957 Contact Map
4cvzA 1 0.8333 8.8 0.961 Contact Map
3n2oA 2 0.4877 7.2 0.962 Contact Map
2p3yA 2 0.6481 6.7 0.963 Contact Map
2qgmA 1 0.7284 6 0.963 Contact Map
1yr2A 1 0.7346 5.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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