SERC - ECOLI - GREMLIN Contacts

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SERC - Phosphoserine aminotransferase

UniProt:	P23721	Sequences: MAQIFNFSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSNYKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFGADVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYSILNDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYGVIDNSDFYRNDVAKANRSRMNVPFQLADSALDKLFLEESFAAGLHALKGHRVVGGMRASIYNAMPLEGVKALTDFMVEFERRHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10946
Length:	362 (339)
Sequences:	23614 (16325)
Seq/√Len:	886.7

ECOLI - SERC ISCS SUFS CSDA DCEB DCEA
BACSU - SERC ISCS1 PUCG ISCS ISCS2 YCBU SUFS
HALSA - CSD Q9HMR6 Q9HR11 MFNA
SULSO - Q97ZK0 Q97VM5 Q97WK1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
275_L	348_K	3.760	1.00
150_P	178_T	3.518	1.00
279_V	351_T	3.294	1.00
56_D	254_K	3.136	1.00
275_L	344_L	3.101	1.00
175_F	192_I	3.018	1.00
93_T	118_V	2.911	1.00
251_L	254_K	2.764	1.00
163_P	171_V	2.677	1.00
242_P	245_A	2.633	1.00
194_A	207_I	2.597	1.00
59_D	257_K	2.573	1.00
185_D	188_R	2.466	1.00
271_Q	344_L	2.456	1.00
68_K	212_E	2.392	1.00
16_A	20_K	2.385	1.00
62_N	185_D	2.248	1.00
122_K	126_D	2.196	1.00
320_A	356_E	2.192	1.00
56_D	250_G	2.180	1.00
336_A	350_L	2.157	1.00
98_D	120_D	2.143	1.00
56_D	257_K	2.093	1.00
93_T	140_S	2.075	1.00
279_V	282_N	2.067	1.00
266_D	270_Q	2.020	1.00
93_T	116_P	2.019	1.00
21_Q	251_L	1.976	1.00
289_D	303_Q	1.969	1.00
22_A	248_L	1.929	1.00
135_R	165_F	1.903	1.00
275_L	279_V	1.876	1.00
274_E	278_G	1.866	1.00
92_T	144_A	1.787	1.00
17_E	255_W	1.762	1.00
287_R	303_Q	1.755	1.00
52_E	250_G	1.753	1.00
133_P	136_E	1.747	1.00
349_A	353_F	1.734	1.00
19_L	23_Q	1.731	1.00
80_F	103_A	1.725	1.00
301_P	333_G	1.716	1.00
189_Y	192_I	1.712	1.00
320_A	353_F	1.711	1.00
287_R	305_A	1.708	1.00
173_A	189_Y	1.692	1.00
92_T	142_N	1.687	1.00
93_T	143_A	1.681	1.00
276_L	338_I	1.679	1.00
135_R	166_G	1.671	1.00
148_Y	162_T	1.667	1.00
283_S	355_V	1.647	1.00
52_E	56_D	1.589	1.00
279_V	348_K	1.583	1.00
270_Q	274_E	1.579	1.00
130_A	133_P	1.576	1.00
309_L	312_L	1.575	1.00
73_H	78_G	1.572	1.00
202_P	248_L	1.567	1.00
15_P	255_W	1.559	1.00
64_P	187_S	1.554	1.00
83_V	191_V	1.550	1.00
20_K	23_Q	1.549	1.00
196_A	249_S	1.531	1.00
6_N	350_L	1.522	1.00
151_N	296_S	1.518	1.00
76_G	176_S	1.510	1.00
118_V	137_W	1.500	1.00
250_G	254_K	1.498	1.00
72_C	79_Q	1.493	1.00
158_A	182_R	1.493	1.00
53_A	250_G	1.485	1.00
191_V	210_V	1.481	1.00
52_E	254_K	1.478	1.00
139_L	143_A	1.478	1.00
20_K	24_Q	1.478	1.00
145_Y	172_A	1.470	1.00
183_P	263_A	1.463	1.00
93_T	142_N	1.452	1.00
55_K	59_D	1.448	1.00
146_M	169_V	1.447	1.00
80_F	172_A	1.438	1.00
120_D	133_P	1.434	1.00
316_E	320_A	1.420	1.00
279_V	355_V	1.384	1.00
273_A	277_Y	1.380	1.00
66_N	212_E	1.360	1.00
199_N	249_S	1.357	1.00
87_I	170_V	1.352	1.00
161_E	165_F	1.347	1.00
267_K	271_Q	1.345	1.00
132_K	135_R	1.341	1.00
179_I	194_A	1.340	1.00
285_F	305_A	1.327	1.00
277_Y	300_V	1.321	1.00
91_K	144_A	1.319	1.00
324_A	334_M	1.315	1.00
95_D	143_A	1.305	1.00
186_V	209_I	1.297	1.00
122_K	128_L	1.297	1.00
89_G	113_Y	1.294	1.00
24_Q	31_G	1.289	1.00
161_E	164_D	1.288	1.00
108_K	111_K	1.287	1.00
105_S	108_K	1.281	1.00
60_L	179_I	1.279	1.00
151_N	178_T	1.278	1.00
264_E	267_K	1.278	1.00
268_I	272_K	1.276	1.00
131_V	165_F	1.273	1.00
62_N	187_S	1.269	1.00
21_Q	24_Q	1.268	1.00
282_N	355_V	1.257	1.00
344_L	348_K	1.256	1.00
133_P	137_W	1.246	1.00
49_V	247_Y	1.244	1.00
200_I	339_Y	1.243	1.00
50_A	246_W	1.240	1.00
302_F	336_A	1.225	1.00
147_H	172_A	1.206	1.00
64_P	212_E	1.203	1.00
178_T	192_I	1.198	1.00
281_D	291_A	1.197	1.00
190_G	211_R	1.195	1.00
263_A	267_K	1.192	1.00
69_V	209_I	1.191	1.00
349_A	352_D	1.190	1.00
17_E	251_L	1.188	1.00
322_L	349_A	1.183	1.00
316_E	357_F	1.183	1.00
109_E	112_K	1.180	1.00
17_E	258_A	1.180	1.00
150_P	192_I	1.178	1.00
14_L	19_L	1.176	1.00
99_A	159_I	1.173	1.00
196_A	201_G	1.170	1.00
56_D	59_D	1.161	1.00
276_L	347_V	1.161	1.00
315_E	319_A	1.158	1.00
131_V	161_E	1.151	1.00
85_L	228_Y	1.147	1.00
132_K	136_E	1.147	1.00
9_S	299_N	1.140	1.00
222_C	229_S	1.131	1.00
343_P	346_G	1.123	1.00
116_P	140_S	1.120	1.00
57_F	253_F	1.120	1.00
79_Q	193_Y	1.111	1.00
135_R	167_A	1.108	1.00
122_K	125_V	1.104	1.00
291_A	294_N	1.104	1.00
278_G	282_N	1.102	1.00
322_L	353_F	1.092	1.00
342_M	346_G	1.089	1.00
316_E	319_A	1.088	1.00
110_A	115_T	1.079	1.00
4_I	349_A	1.077	1.00
61_L	209_I	1.076	1.00
126_D	291_A	1.076	1.00
109_E	113_Y	1.076	1.00
106_A	110_A	1.066	1.00
196_A	205_L	1.065	1.00
107_I	110_A	1.064	1.00
148_Y	171_V	1.062	1.00
312_L	316_E	1.056	1.00
96_Y	107_I	1.047	1.00
48_Q	52_E	1.046	1.00
122_K	130_A	1.045	1.00
170_V	214_L	1.044	1.00
8_S	12_A	1.044	1.00
351_T	355_V	1.042	1.00
60_L	253_F	1.038	1.00
353_F	356_E	1.034	1.00
276_L	300_V	1.032	1.00
172_A	193_Y	1.032	1.00
64_P	68_K	1.027	1.00
45_E	48_Q	1.026	1.00
345_E	348_K	1.023	1.00
191_V	214_L	1.021	1.00
265_M	268_I	1.021	1.00
183_P	266_D	1.016	1.00
105_S	109_E	1.014	1.00
118_V	140_S	1.013	1.00
105_S	110_A	1.013	1.00
95_D	137_W	1.002	1.00
85_L	221_A	1.002	1.00
31_G	45_E	0.995	1.00
322_L	350_L	0.993	1.00
276_L	336_A	0.990	1.00
87_I	191_V	0.987	1.00
268_I	271_Q	0.987	1.00
280_I	302_F	0.985	1.00
55_K	58_R	0.984	1.00
251_L	255_W	0.984	1.00
26_L	244_F	0.976	1.00
61_L	186_V	0.975	1.00
289_D	301_P	0.974	1.00
259_N	265_M	0.972	1.00
151_N	297_R	0.969	1.00
41_H	45_E	0.969	1.00
150_P	173_A	0.968	1.00
107_I	111_K	0.966	1.00
53_A	56_D	0.964	1.00
314_L	326_K	0.962	1.00
254_K	258_A	0.962	1.00
119_F	137_W	0.960	1.00
265_M	340_N	0.960	1.00
134_M	146_M	0.960	1.00
311_K	315_E	0.959	1.00
42_R	323_H	0.954	1.00
272_K	347_V	0.954	1.00
348_K	352_D	0.953	1.00
41_H	318_F	0.952	1.00
261_G	264_E	0.952	1.00
88_L	115_T	0.951	1.00
178_T	182_R	0.950	1.00
47_I	51_E	0.949	1.00
57_F	207_I	0.947	1.00
211_R	214_L	0.946	1.00
273_A	300_V	0.945	1.00
8_S	342_M	0.941	1.00
179_I	184_I	0.931	1.00
292_K	295_R	0.931	1.00
338_I	347_V	0.930	1.00
199_N	253_F	0.927	1.00
271_Q	275_L	0.927	1.00
170_V	191_V	0.924	1.00
150_P	184_I	0.922	1.00
259_N	264_E	0.919	1.00
8_S	341_A	0.918	1.00
205_L	246_W	0.917	1.00
170_V	190_G	0.914	1.00
18_V	252_V	0.908	1.00
63_V	68_K	0.905	1.00
131_V	134_M	0.896	1.00
131_V	135_R	0.895	1.00
97_V	148_Y	0.895	1.00
283_S	286_Y	0.895	1.00
279_V	352_D	0.892	1.00
315_E	318_F	0.887	1.00
49_V	52_E	0.884	1.00
53_A	246_W	0.882	1.00
63_V	209_I	0.880	1.00
205_L	245_A	0.877	1.00
316_E	353_F	0.876	1.00
175_F	178_T	0.873	1.00
278_G	281_D	0.872	1.00
8_S	339_Y	0.863	1.00
352_D	356_E	0.860	1.00
8_S	13_M	0.857	1.00
80_F	193_Y	0.856	1.00
19_L	26_L	0.854	1.00
324_A	336_A	0.852	1.00
106_A	109_E	0.846	1.00
140_S	143_A	0.840	1.00
228_Y	231_L	0.836	1.00
277_Y	295_R	0.836	1.00
277_Y	281_D	0.830	1.00
172_A	191_V	0.825	1.00
345_E	349_A	0.822	1.00
286_Y	304_L	0.819	1.00
9_S	337_S	0.816	1.00
108_K	112_K	0.816	1.00
264_E	268_I	0.815	1.00
190_G	213_D	0.814	1.00
265_M	269_N	0.814	1.00
313_F	354_M	0.812	1.00
276_L	350_L	0.810	1.00
350_L	354_M	0.807	1.00
134_M	162_T	0.806	1.00
94_A	107_I	0.801	1.00
222_C	228_Y	0.797	1.00
184_I	192_I	0.794	1.00
78_G	82_A	0.794	1.00
267_K	270_Q	0.789	1.00
149_C	159_I	0.787	1.00
70_L	82_A	0.786	1.00
128_L	159_I	0.786	1.00
65_S	212_E	0.784	1.00
56_D	60_L	0.782	1.00
55_K	66_N	0.781	1.00
313_F	357_F	0.779	1.00
104_A	147_H	0.778	1.00
281_D	292_K	0.778	1.00
96_Y	147_H	0.777	1.00
139_L	165_F	0.777	1.00
270_Q	297_R	0.776	1.00
15_P	18_V	0.776	1.00
149_C	153_T	0.775	1.00
179_I	253_F	0.774	1.00
277_Y	288_N	0.773	1.00
186_V	192_I	0.772	1.00
203_A	243_T	0.772	1.00
312_L	315_E	0.772	1.00
60_L	257_K	0.768	1.00
83_V	208_V	0.764	1.00
207_I	249_S	0.761	1.00
118_V	143_A	0.761	1.00
263_A	266_D	0.758	1.00
59_D	62_N	0.757	1.00
128_L	294_N	0.756	1.00
183_P	262_V	0.753	1.00
17_E	20_K	0.753	1.00
63_V	186_V	0.750	1.00
22_A	26_L	0.749	1.00
150_P	158_A	0.744	1.00
317_S	324_A	0.744	1.00
68_K	187_S	0.743	1.00
176_S	195_G	0.743	1.00
179_I	199_N	0.741	1.00
76_G	193_Y	0.740	1.00
186_V	189_Y	0.738	1.00
148_Y	173_A	0.737	1.00
56_D	253_F	0.734	1.00
22_A	244_F	0.731	1.00
89_G	92_T	0.730	1.00
58_R	63_V	0.728	1.00
40_S	43_G	0.726	1.00
314_L	324_A	0.725	1.00
272_K	344_L	0.724	1.00
135_R	161_E	0.722	1.00
229_S	233_D	0.719	1.00
57_F	71_F	0.717	1.00
25_E	49_V	0.715	1.00
268_I	344_L	0.715	1.00
61_L	179_I	0.714	1.00
55_K	65_S	0.709	1.00
162_T	165_F	0.708	1.00
259_N	268_I	0.707	1.00
214_L	217_K	0.704	1.00
275_L	347_V	0.703	1.00
289_D	333_G	0.701	1.00
256_L	265_M	0.701	1.00
318_F	323_H	0.698	1.00
18_V	251_L	0.698	1.00
6_N	347_V	0.697	1.00
275_L	351_T	0.697	1.00
62_N	183_P	0.695	1.00
304_L	358_E	0.694	1.00
269_N	298_M	0.692	1.00
151_N	158_A	0.690	1.00
76_G	80_F	0.690	1.00
58_R	66_N	0.688	1.00
352_D	355_V	0.685	1.00
276_L	280_I	0.684	1.00
85_L	109_E	0.678	1.00
342_M	347_V	0.678	1.00
16_A	23_Q	0.678	1.00
84_P	106_A	0.677	1.00
79_Q	208_V	0.677	1.00
212_E	216_G	0.676	1.00
15_P	340_N	0.674	1.00
310_D	326_K	0.673	1.00
58_R	65_S	0.671	1.00
205_L	249_S	0.670	1.00
256_L	262_V	0.669	1.00
279_V	283_S	0.669	1.00
190_G	214_L	0.668	1.00
68_K	211_R	0.668	1.00
275_L	278_G	0.667	1.00
72_C	82_A	0.664	1.00
50_A	243_T	0.664	1.00
200_I	340_N	0.664	1.00
77_R	81_A	0.656	1.00
109_E	228_Y	0.656	1.00
300_V	338_I	0.656	1.00
58_R	69_V	0.654	1.00
271_Q	274_E	0.652	1.00
21_Q	25_E	0.652	1.00
17_E	259_N	0.649	1.00
198_K	335_R	0.649	1.00
287_R	290_V	0.649	1.00
54_E	71_F	0.646	1.00
83_V	172_A	0.646	1.00
254_K	257_K	0.645	1.00
119_F	134_M	0.644	1.00
261_G	265_M	0.643	1.00
150_P	175_F	0.643	1.00
135_R	139_L	0.640	1.00
283_S	351_T	0.640	1.00
139_L	167_A	0.639	1.00
14_L	26_L	0.637	1.00
249_S	253_F	0.636	1.00
262_V	266_D	0.636	1.00
16_A	19_L	0.634	1.00
50_A	241_P	0.631	1.00
276_L	351_T	0.630	1.00
25_E	247_Y	0.629	1.00
147_H	193_Y	0.627	1.00
54_E	58_R	0.625	1.00
21_Q	247_Y	0.624	1.00
350_L	353_F	0.624	1.00
232_N	235_G	0.623	1.00
122_K	133_P	0.622	1.00
304_L	313_F	0.618	1.00
283_S	358_E	0.617	1.00
54_E	233_D	0.616	1.00
231_L	238_F	0.614	1.00
277_Y	296_S	0.613	1.00
308_A	313_F	0.612	1.00
4_I	322_L	0.612	1.00
299_N	337_S	0.612	1.00
24_Q	49_V	0.609	1.00
270_Q	273_A	0.607	1.00
181_S	298_M	0.607	1.00
222_C	231_L	0.606	1.00
116_P	142_N	0.604	1.00
63_V	69_V	0.602	1.00
182_R	297_R	0.598	1.00
255_W	340_N	0.597	1.00
348_K	351_T	0.597	1.00
250_G	253_F	0.595	1.00
110_A	117_N	0.594	1.00
61_L	194_A	0.594	1.00
81_A	85_L	0.593	1.00
181_S	199_N	0.592	1.00
37_M	241_P	0.591	1.00
304_L	307_S	0.590	1.00
268_I	340_N	0.590	1.00
150_P	182_R	0.590	1.00
259_N	340_N	0.588	1.00
52_E	55_K	0.588	1.00
347_V	351_T	0.586	1.00
51_E	55_K	0.585	1.00
276_L	279_V	0.581	1.00
255_W	259_N	0.580	1.00
280_I	354_M	0.579	1.00
63_V	187_S	0.578	1.00
75_G	206_T	0.576	1.00
313_F	334_M	0.576	1.00
113_Y	116_P	0.573	1.00
94_A	110_A	0.572	1.00
139_L	146_M	0.571	1.00
97_V	100_G	0.571	1.00
93_T	141_D	0.568	1.00
273_A	295_R	0.566	1.00
192_I	209_I	0.565	1.00
336_A	354_M	0.565	1.00
304_L	354_M	0.564	1.00
92_T	115_T	0.563	1.00
68_K	215_L	0.562	1.00
11_P	197_Q	0.560	1.00
99_A	121_A	0.558	1.00
12_A	200_I	0.558	1.00
95_D	139_L	0.556	1.00
255_W	258_A	0.554	1.00
317_S	353_F	0.554	1.00
339_Y	342_M	0.553	1.00
128_L	157_I	0.553	1.00
146_M	162_T	0.551	1.00
274_E	293_A	0.550	1.00
145_Y	170_V	0.549	1.00
191_V	208_V	0.549	1.00
18_V	248_L	0.548	1.00
15_P	259_N	0.548	1.00
38_E	43_G	0.547	1.00
98_D	104_A	0.547	1.00
22_A	245_A	0.546	1.00
134_M	139_L	0.546	1.00
154_I	331_V	0.545	1.00
122_K	127_G	0.545	1.00
11_P	32_L	0.544	1.00
84_P	87_I	0.544	1.00
170_V	213_D	0.543	1.00
129_R	159_I	0.543	1.00
44_K	48_Q	0.542	1.00
40_S	323_H	0.541	1.00
210_V	215_L	0.541	1.00
109_E	114_C	0.539	1.00
280_I	351_T	0.539	1.00
148_Y	159_I	0.538	1.00
4_I	346_G	0.537	1.00
272_K	342_M	0.535	1.00
149_C	152_E	0.534	1.00
23_Q	26_L	0.534	1.00
87_I	214_L	0.534	1.00
199_N	256_L	0.533	1.00
54_E	237_M	0.531	1.00
57_F	69_V	0.530	1.00
130_A	136_E	0.526	1.00
95_D	118_V	0.525	1.00
25_E	244_F	0.524	1.00
272_K	338_I	0.523	1.00
175_F	179_I	0.522	1.00
51_E	54_E	0.522	1.00
179_I	249_S	0.522	1.00
120_D	137_W	0.521	1.00
151_N	182_R	0.519	1.00
32_L	45_E	0.517	1.00
90_D	114_C	0.516	1.00
41_H	321_G	0.516	1.00
131_V	162_T	0.516	1.00
95_D	146_M	0.516	1.00
49_V	53_A	0.514	1.00
102_W	331_V	0.514	1.00
126_D	130_A	0.513	1.00
49_V	250_G	0.513	1.00
46_F	50_A	0.511	1.00
266_D	297_R	0.509	1.00
128_L	132_K	0.508	1.00
131_V	160_D	0.508	1.00
101_Y	330_V	0.505	1.00
82_A	221_A	0.505	1.00
327_G	330_V	0.504	1.00
102_W	105_S	0.504	1.00
158_A	178_T	0.503	1.00
253_F	257_K	0.502	1.00
5_F	346_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qm2A	2	0.9006	100	0.411	Contact Map
2c0rA	2	0.9751	100	0.412	Contact Map
3e77A	2	0.9641	100	0.414	Contact Map
4xk1A	2	0.9669	100	0.421	Contact Map
1w23A	2	0.9751	100	0.423	Contact Map
3m5uA	2	0.9558	100	0.425	Contact Map
3e9kA	2	0.953	100	0.438	Contact Map
3ffrA	2	0.9448	100	0.453	Contact Map
3islA	2	0.9475	100	0.454	Contact Map
3zrpA	2	0.9254	100	0.461	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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