GREMLIN Database
SERC - Phosphoserine aminotransferase
UniProt: P23721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10946
Length: 362 (339)
Sequences: 23614 (16325)
Seq/√Len: 886.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_L348_K3.7601.00
150_P178_T3.5181.00
279_V351_T3.2941.00
56_D254_K3.1361.00
275_L344_L3.1011.00
175_F192_I3.0181.00
93_T118_V2.9111.00
251_L254_K2.7641.00
163_P171_V2.6771.00
242_P245_A2.6331.00
194_A207_I2.5971.00
59_D257_K2.5731.00
185_D188_R2.4661.00
271_Q344_L2.4561.00
68_K212_E2.3921.00
16_A20_K2.3851.00
62_N185_D2.2481.00
122_K126_D2.1961.00
320_A356_E2.1921.00
56_D250_G2.1801.00
336_A350_L2.1571.00
98_D120_D2.1431.00
56_D257_K2.0931.00
93_T140_S2.0751.00
279_V282_N2.0671.00
266_D270_Q2.0201.00
93_T116_P2.0191.00
21_Q251_L1.9761.00
289_D303_Q1.9691.00
22_A248_L1.9291.00
135_R165_F1.9031.00
275_L279_V1.8761.00
274_E278_G1.8661.00
92_T144_A1.7871.00
17_E255_W1.7621.00
287_R303_Q1.7551.00
52_E250_G1.7531.00
133_P136_E1.7471.00
349_A353_F1.7341.00
19_L23_Q1.7311.00
80_F103_A1.7251.00
301_P333_G1.7161.00
189_Y192_I1.7121.00
320_A353_F1.7111.00
287_R305_A1.7081.00
173_A189_Y1.6921.00
92_T142_N1.6871.00
93_T143_A1.6811.00
276_L338_I1.6791.00
135_R166_G1.6711.00
148_Y162_T1.6671.00
283_S355_V1.6471.00
52_E56_D1.5891.00
279_V348_K1.5831.00
270_Q274_E1.5791.00
130_A133_P1.5761.00
309_L312_L1.5751.00
73_H78_G1.5721.00
202_P248_L1.5671.00
15_P255_W1.5591.00
64_P187_S1.5541.00
83_V191_V1.5501.00
20_K23_Q1.5491.00
196_A249_S1.5311.00
6_N350_L1.5221.00
151_N296_S1.5181.00
76_G176_S1.5101.00
118_V137_W1.5001.00
250_G254_K1.4981.00
72_C79_Q1.4931.00
158_A182_R1.4931.00
53_A250_G1.4851.00
191_V210_V1.4811.00
52_E254_K1.4781.00
139_L143_A1.4781.00
20_K24_Q1.4781.00
145_Y172_A1.4701.00
183_P263_A1.4631.00
93_T142_N1.4521.00
55_K59_D1.4481.00
146_M169_V1.4471.00
80_F172_A1.4381.00
120_D133_P1.4341.00
316_E320_A1.4201.00
279_V355_V1.3841.00
273_A277_Y1.3801.00
66_N212_E1.3601.00
199_N249_S1.3571.00
87_I170_V1.3521.00
161_E165_F1.3471.00
267_K271_Q1.3451.00
132_K135_R1.3411.00
179_I194_A1.3401.00
285_F305_A1.3271.00
277_Y300_V1.3211.00
91_K144_A1.3191.00
324_A334_M1.3151.00
95_D143_A1.3051.00
186_V209_I1.2971.00
122_K128_L1.2971.00
89_G113_Y1.2941.00
24_Q31_G1.2891.00
161_E164_D1.2881.00
108_K111_K1.2871.00
105_S108_K1.2811.00
60_L179_I1.2791.00
151_N178_T1.2781.00
264_E267_K1.2781.00
268_I272_K1.2761.00
131_V165_F1.2731.00
62_N187_S1.2691.00
21_Q24_Q1.2681.00
282_N355_V1.2571.00
344_L348_K1.2561.00
133_P137_W1.2461.00
49_V247_Y1.2441.00
200_I339_Y1.2431.00
50_A246_W1.2401.00
302_F336_A1.2251.00
147_H172_A1.2061.00
64_P212_E1.2031.00
178_T192_I1.1981.00
281_D291_A1.1971.00
190_G211_R1.1951.00
263_A267_K1.1921.00
69_V209_I1.1911.00
349_A352_D1.1901.00
17_E251_L1.1881.00
322_L349_A1.1831.00
316_E357_F1.1831.00
109_E112_K1.1801.00
17_E258_A1.1801.00
150_P192_I1.1781.00
14_L19_L1.1761.00
99_A159_I1.1731.00
196_A201_G1.1701.00
56_D59_D1.1611.00
276_L347_V1.1611.00
315_E319_A1.1581.00
131_V161_E1.1511.00
85_L228_Y1.1471.00
132_K136_E1.1471.00
9_S299_N1.1401.00
222_C229_S1.1311.00
343_P346_G1.1231.00
116_P140_S1.1201.00
57_F253_F1.1201.00
79_Q193_Y1.1111.00
135_R167_A1.1081.00
122_K125_V1.1041.00
291_A294_N1.1041.00
278_G282_N1.1021.00
322_L353_F1.0921.00
342_M346_G1.0891.00
316_E319_A1.0881.00
110_A115_T1.0791.00
4_I349_A1.0771.00
61_L209_I1.0761.00
126_D291_A1.0761.00
109_E113_Y1.0761.00
106_A110_A1.0661.00
196_A205_L1.0651.00
107_I110_A1.0641.00
148_Y171_V1.0621.00
312_L316_E1.0561.00
96_Y107_I1.0471.00
48_Q52_E1.0461.00
122_K130_A1.0451.00
170_V214_L1.0441.00
8_S12_A1.0441.00
351_T355_V1.0421.00
60_L253_F1.0381.00
353_F356_E1.0341.00
276_L300_V1.0321.00
172_A193_Y1.0321.00
64_P68_K1.0271.00
45_E48_Q1.0261.00
345_E348_K1.0231.00
191_V214_L1.0211.00
265_M268_I1.0211.00
183_P266_D1.0161.00
105_S109_E1.0141.00
118_V140_S1.0131.00
105_S110_A1.0131.00
95_D137_W1.0021.00
85_L221_A1.0021.00
31_G45_E0.9951.00
322_L350_L0.9931.00
276_L336_A0.9901.00
87_I191_V0.9871.00
268_I271_Q0.9871.00
280_I302_F0.9851.00
55_K58_R0.9841.00
251_L255_W0.9841.00
26_L244_F0.9761.00
61_L186_V0.9751.00
289_D301_P0.9741.00
259_N265_M0.9721.00
151_N297_R0.9691.00
41_H45_E0.9691.00
150_P173_A0.9681.00
107_I111_K0.9661.00
53_A56_D0.9641.00
314_L326_K0.9621.00
254_K258_A0.9621.00
119_F137_W0.9601.00
265_M340_N0.9601.00
134_M146_M0.9601.00
311_K315_E0.9591.00
42_R323_H0.9541.00
272_K347_V0.9541.00
348_K352_D0.9531.00
41_H318_F0.9521.00
261_G264_E0.9521.00
88_L115_T0.9511.00
178_T182_R0.9501.00
47_I51_E0.9491.00
57_F207_I0.9471.00
211_R214_L0.9461.00
273_A300_V0.9451.00
8_S342_M0.9411.00
179_I184_I0.9311.00
292_K295_R0.9311.00
338_I347_V0.9301.00
199_N253_F0.9271.00
271_Q275_L0.9271.00
170_V191_V0.9241.00
150_P184_I0.9221.00
259_N264_E0.9191.00
8_S341_A0.9181.00
205_L246_W0.9171.00
170_V190_G0.9141.00
18_V252_V0.9081.00
63_V68_K0.9051.00
131_V134_M0.8961.00
131_V135_R0.8951.00
97_V148_Y0.8951.00
283_S286_Y0.8951.00
279_V352_D0.8921.00
315_E318_F0.8871.00
49_V52_E0.8841.00
53_A246_W0.8821.00
63_V209_I0.8801.00
205_L245_A0.8771.00
316_E353_F0.8761.00
175_F178_T0.8731.00
278_G281_D0.8721.00
8_S339_Y0.8631.00
352_D356_E0.8601.00
8_S13_M0.8571.00
80_F193_Y0.8561.00
19_L26_L0.8541.00
324_A336_A0.8521.00
106_A109_E0.8461.00
140_S143_A0.8401.00
228_Y231_L0.8361.00
277_Y295_R0.8361.00
277_Y281_D0.8301.00
172_A191_V0.8251.00
345_E349_A0.8221.00
286_Y304_L0.8191.00
9_S337_S0.8161.00
108_K112_K0.8161.00
264_E268_I0.8151.00
190_G213_D0.8141.00
265_M269_N0.8141.00
313_F354_M0.8121.00
276_L350_L0.8101.00
350_L354_M0.8071.00
134_M162_T0.8061.00
94_A107_I0.8011.00
222_C228_Y0.7971.00
184_I192_I0.7941.00
78_G82_A0.7941.00
267_K270_Q0.7891.00
149_C159_I0.7871.00
70_L82_A0.7861.00
128_L159_I0.7861.00
65_S212_E0.7841.00
56_D60_L0.7821.00
55_K66_N0.7811.00
313_F357_F0.7791.00
104_A147_H0.7781.00
281_D292_K0.7781.00
96_Y147_H0.7771.00
139_L165_F0.7771.00
270_Q297_R0.7761.00
15_P18_V0.7761.00
149_C153_T0.7751.00
179_I253_F0.7741.00
277_Y288_N0.7731.00
186_V192_I0.7721.00
203_A243_T0.7721.00
312_L315_E0.7721.00
60_L257_K0.7681.00
83_V208_V0.7641.00
207_I249_S0.7611.00
118_V143_A0.7611.00
263_A266_D0.7581.00
59_D62_N0.7571.00
128_L294_N0.7561.00
183_P262_V0.7531.00
17_E20_K0.7531.00
63_V186_V0.7501.00
22_A26_L0.7491.00
150_P158_A0.7441.00
317_S324_A0.7441.00
68_K187_S0.7431.00
176_S195_G0.7431.00
179_I199_N0.7411.00
76_G193_Y0.7401.00
186_V189_Y0.7381.00
148_Y173_A0.7371.00
56_D253_F0.7341.00
22_A244_F0.7311.00
89_G92_T0.7301.00
58_R63_V0.7281.00
40_S43_G0.7261.00
314_L324_A0.7251.00
272_K344_L0.7241.00
135_R161_E0.7221.00
229_S233_D0.7191.00
57_F71_F0.7171.00
25_E49_V0.7151.00
268_I344_L0.7151.00
61_L179_I0.7141.00
55_K65_S0.7091.00
162_T165_F0.7081.00
259_N268_I0.7071.00
214_L217_K0.7041.00
275_L347_V0.7031.00
289_D333_G0.7011.00
256_L265_M0.7011.00
318_F323_H0.6981.00
18_V251_L0.6981.00
6_N347_V0.6971.00
275_L351_T0.6971.00
62_N183_P0.6951.00
304_L358_E0.6941.00
269_N298_M0.6921.00
151_N158_A0.6901.00
76_G80_F0.6901.00
58_R66_N0.6881.00
352_D355_V0.6851.00
276_L280_I0.6841.00
85_L109_E0.6781.00
342_M347_V0.6781.00
16_A23_Q0.6781.00
84_P106_A0.6771.00
79_Q208_V0.6771.00
212_E216_G0.6761.00
15_P340_N0.6741.00
310_D326_K0.6731.00
58_R65_S0.6711.00
205_L249_S0.6701.00
256_L262_V0.6691.00
279_V283_S0.6691.00
190_G214_L0.6681.00
68_K211_R0.6681.00
275_L278_G0.6671.00
72_C82_A0.6641.00
50_A243_T0.6641.00
200_I340_N0.6641.00
77_R81_A0.6561.00
109_E228_Y0.6561.00
300_V338_I0.6561.00
58_R69_V0.6541.00
271_Q274_E0.6521.00
21_Q25_E0.6521.00
17_E259_N0.6491.00
198_K335_R0.6491.00
287_R290_V0.6491.00
54_E71_F0.6461.00
83_V172_A0.6461.00
254_K257_K0.6451.00
119_F134_M0.6441.00
261_G265_M0.6431.00
150_P175_F0.6431.00
135_R139_L0.6401.00
283_S351_T0.6401.00
139_L167_A0.6391.00
14_L26_L0.6371.00
249_S253_F0.6361.00
262_V266_D0.6361.00
16_A19_L0.6341.00
50_A241_P0.6311.00
276_L351_T0.6301.00
25_E247_Y0.6291.00
147_H193_Y0.6271.00
54_E58_R0.6251.00
21_Q247_Y0.6241.00
350_L353_F0.6241.00
232_N235_G0.6231.00
122_K133_P0.6221.00
304_L313_F0.6181.00
283_S358_E0.6171.00
54_E233_D0.6161.00
231_L238_F0.6141.00
277_Y296_S0.6131.00
308_A313_F0.6121.00
4_I322_L0.6121.00
299_N337_S0.6121.00
24_Q49_V0.6091.00
270_Q273_A0.6071.00
181_S298_M0.6071.00
222_C231_L0.6061.00
116_P142_N0.6041.00
63_V69_V0.6021.00
182_R297_R0.5981.00
255_W340_N0.5971.00
348_K351_T0.5971.00
250_G253_F0.5951.00
110_A117_N0.5941.00
61_L194_A0.5941.00
81_A85_L0.5931.00
181_S199_N0.5921.00
37_M241_P0.5911.00
304_L307_S0.5901.00
268_I340_N0.5901.00
150_P182_R0.5901.00
259_N340_N0.5881.00
52_E55_K0.5881.00
347_V351_T0.5861.00
51_E55_K0.5851.00
276_L279_V0.5811.00
255_W259_N0.5801.00
280_I354_M0.5791.00
63_V187_S0.5781.00
75_G206_T0.5761.00
313_F334_M0.5761.00
113_Y116_P0.5731.00
94_A110_A0.5721.00
139_L146_M0.5711.00
97_V100_G0.5711.00
93_T141_D0.5681.00
273_A295_R0.5661.00
192_I209_I0.5651.00
336_A354_M0.5651.00
304_L354_M0.5641.00
92_T115_T0.5631.00
68_K215_L0.5621.00
11_P197_Q0.5601.00
99_A121_A0.5581.00
12_A200_I0.5581.00
95_D139_L0.5561.00
255_W258_A0.5541.00
317_S353_F0.5541.00
339_Y342_M0.5531.00
128_L157_I0.5531.00
146_M162_T0.5511.00
274_E293_A0.5501.00
145_Y170_V0.5491.00
191_V208_V0.5491.00
18_V248_L0.5481.00
15_P259_N0.5481.00
38_E43_G0.5471.00
98_D104_A0.5471.00
22_A245_A0.5461.00
134_M139_L0.5461.00
154_I331_V0.5451.00
122_K127_G0.5451.00
11_P32_L0.5441.00
84_P87_I0.5441.00
170_V213_D0.5431.00
129_R159_I0.5431.00
44_K48_Q0.5421.00
40_S323_H0.5411.00
210_V215_L0.5411.00
109_E114_C0.5391.00
280_I351_T0.5391.00
148_Y159_I0.5381.00
4_I346_G0.5371.00
272_K342_M0.5351.00
149_C152_E0.5341.00
23_Q26_L0.5341.00
87_I214_L0.5341.00
199_N256_L0.5331.00
54_E237_M0.5311.00
57_F69_V0.5301.00
130_A136_E0.5261.00
95_D118_V0.5251.00
25_E244_F0.5241.00
272_K338_I0.5231.00
175_F179_I0.5221.00
51_E54_E0.5221.00
179_I249_S0.5221.00
120_D137_W0.5211.00
151_N182_R0.5191.00
32_L45_E0.5171.00
90_D114_C0.5161.00
41_H321_G0.5161.00
131_V162_T0.5161.00
95_D146_M0.5161.00
49_V53_A0.5141.00
102_W331_V0.5141.00
126_D130_A0.5131.00
49_V250_G0.5131.00
46_F50_A0.5111.00
266_D297_R0.5091.00
128_L132_K0.5081.00
131_V160_D0.5081.00
101_Y330_V0.5051.00
82_A221_A0.5051.00
327_G330_V0.5041.00
102_W105_S0.5041.00
158_A178_T0.5031.00
253_F257_K0.5021.00
5_F346_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qm2A 2 0.9006 100 0.411 Contact Map
2c0rA 2 0.9751 100 0.412 Contact Map
3e77A 2 0.9641 100 0.414 Contact Map
4xk1A 2 0.9669 100 0.421 Contact Map
1w23A 2 0.9751 100 0.423 Contact Map
3m5uA 2 0.9558 100 0.425 Contact Map
3e9kA 2 0.953 100 0.438 Contact Map
3ffrA 2 0.9448 100 0.453 Contact Map
3islA 2 0.9475 100 0.454 Contact Map
3zrpA 2 0.9254 100 0.461 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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