GREMLIN Database
GLXK1 - Glycerate 2-kinase
UniProt: P23524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11175
Length: 381 (371)
Sequences: 2552 (1926)
Seq/√Len: 100.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S114_T3.4431.00
67_G71_E3.1961.00
269_I307_G2.8911.00
128_N187_V2.7891.00
29_E367_R2.6291.00
25_K363_C2.6191.00
139_N205_S2.5851.00
66_T116_E2.5141.00
77_W120_Q2.4541.00
79_I126_A2.4301.00
273_T278_L2.3931.00
295_I321_G2.3921.00
128_N189_R2.3881.00
234_K240_D2.3781.00
279_E314_K2.3531.00
143_A153_L2.3221.00
5_I23_I2.3161.00
294_R325_S2.3011.00
279_E311_V2.2341.00
24_E38_S2.2021.00
277_N280_E2.2011.00
27_F370_A2.1951.00
29_E363_C2.1781.00
151_A176_I2.1451.00
64_W74_N2.1411.00
71_E103_K2.1351.00
241_V255_A2.1321.00
141_G229_Y2.1061.00
22_A26_G2.0791.00
62_H74_N2.0591.00
215_S218_M2.0361.00
199_V223_D1.9981.00
53_I78_G1.9781.00
37_V281_H1.9761.00
4_V285_C1.9691.00
24_E28_R1.9331.00
2_K35_Q1.9081.00
214_A222_L1.8991.00
20_A38_S1.8981.00
367_R371_A1.8981.00
84_K127_T1.8771.00
161_I167_S1.8751.00
100_P103_K1.8701.00
23_I366_S1.8611.00
151_A179_L1.8411.00
233_I260_F1.8411.00
61_R124_S1.8401.00
131_I257_L1.8391.00
155_D159_N1.8321.00
191_A271_I1.8251.00
90_M253_M1.8191.00
42_A48_T1.7981.00
123_E182_R1.7871.00
210_P219_I1.7831.00
21_Q38_S1.7761.00
76_S92_A1.7701.00
18_E359_Y1.7361.00
299_S306_I1.7131.00
65_V116_E1.7051.00
127_T185_D1.6951.00
129_I186_C1.6921.00
64_W72_K1.6901.00
295_I323_A1.6771.00
147_Q163_F1.6671.00
66_T110_T1.6661.00
155_D170_T1.6551.00
129_I188_I1.6541.00
50_E60_E1.6461.00
105_D108_V1.6451.00
90_M133_I1.6411.00
192_C265_L1.6351.00
133_I190_V1.6211.00
205_S219_I1.6051.00
5_I36_Y1.6051.00
77_W124_S1.5961.00
2_K284_D1.5861.00
161_I171_L1.5651.00
68_P98_L1.5611.00
187_V264_E1.5601.00
14_L358_A1.5541.00
123_E180_D1.5501.00
60_E76_S1.5331.00
41_V304_V1.5261.00
99_V103_K1.5181.00
153_L171_L1.5171.00
39_V281_H1.5161.00
321_G338_I1.5051.00
3_I287_L1.5001.00
231_E242_K1.4941.00
56_T81_G1.4941.00
67_G73_V1.4901.00
146_V256_A1.4901.00
279_E315_Y1.4861.00
162_G167_S1.4811.00
282_I317_K1.4741.00
278_L311_V1.4721.00
23_I289_I1.4661.00
15_S18_E1.4641.00
166_G225_N1.4621.00
147_Q153_L1.4611.00
322_I366_S1.4511.00
120_Q124_S1.4511.00
93_A114_T1.4481.00
199_V242_K1.4311.00
269_I273_T1.4311.00
357_G360_D1.4301.00
19_V362_I1.4271.00
152_K160_E1.4241.00
14_L359_Y1.4241.00
313_K339_D1.4151.00
66_T70_G1.4141.00
198_L255_A1.4061.00
350_T353_E1.4031.00
127_T186_C1.3650.99
152_K175_D1.3620.99
349_G354_A1.3540.99
288_V308_V1.3470.99
274_T311_V1.3450.99
189_R266_K1.3440.99
2_K37_V1.3410.99
107_L221_E1.3410.99
111_S138_T1.3380.99
146_V260_F1.3350.99
146_V151_A1.3320.99
65_V93_A1.3180.99
7_P23_I1.3130.99
63_A77_W1.3080.99
31_F34_A1.3010.99
7_P20_A1.3000.99
195_T202_N1.2970.99
165_G225_N1.2920.99
284_D317_K1.2910.99
247_A258_M1.2790.99
72_K116_E1.2760.99
122_L186_C1.2620.99
41_V273_T1.2480.99
143_A161_I1.2470.99
122_L180_D1.2450.99
7_P16_A1.2330.99
122_L182_R1.2280.99
233_I255_A1.2270.99
12_E97_E1.2260.99
63_A117_L1.2220.99
280_E283_H1.2070.99
164_G167_S1.2000.99
205_S214_A1.1980.99
119_L180_D1.1960.98
342_F369_I1.1950.98
282_I311_V1.1900.98
349_G361_N1.1880.98
190_V265_L1.1840.98
282_I288_V1.1810.98
108_V166_G1.1790.98
202_N301_H1.1790.98
111_S253_M1.1650.98
165_G222_L1.1640.98
80_S87_F1.1610.98
169_N221_E1.1600.98
93_A117_L1.1590.98
27_F34_A1.1560.98
199_V227_S1.1520.98
257_L263_A1.1490.98
9_S46_E1.1470.98
206_R220_V1.1430.98
112_R163_F1.1400.98
27_F36_Y1.1380.98
75_A117_L1.1360.98
143_A229_Y1.1270.98
366_S370_A1.1210.98
25_K359_Y1.1180.98
107_L218_M1.1170.98
147_Q160_E1.1080.98
118_I188_I1.1010.97
49_V92_A1.1000.97
346_T361_N1.0970.97
244_V258_M1.0940.97
52_M275_A1.0930.97
130_I271_I1.0840.97
49_V89_E1.0790.97
323_A326_L1.0730.97
5_I20_A1.0710.97
214_A219_I1.0660.97
14_L19_V1.0640.97
342_F372_T1.0530.97
227_S231_E1.0510.97
61_R77_W1.0510.97
325_S348_I1.0470.96
309_A338_I1.0460.96
112_R148_A1.0440.96
206_R219_I1.0410.96
266_K274_T1.0330.96
154_C173_D1.0270.96
112_R116_E1.0260.96
118_I145_M1.0230.96
183_L188_I1.0210.96
53_I60_E1.0210.96
50_E54_A1.0190.96
119_L123_E1.0170.96
23_I322_I1.0170.96
167_S170_T1.0120.96
353_E357_G1.0080.96
85_T128_N1.0060.96
143_A147_Q0.9980.95
133_I250_A0.9960.95
4_V317_K0.9890.95
273_T311_V0.9870.95
342_F365_A0.9840.95
90_M111_S0.9820.95
24_E36_Y0.9810.95
345_L354_A0.9770.95
145_M253_M0.9710.95
49_V132_G0.9660.95
153_L229_Y0.9620.94
56_T80_S0.9610.94
156_A172_N0.9590.94
306_I310_N0.9560.94
239_V262_G0.9520.94
218_M221_E0.9410.94
195_T301_H0.9400.94
88_I117_L0.9400.94
143_A171_L0.9400.94
169_N225_N0.9390.94
207_I297_S0.9360.94
26_G30_I0.9350.93
305_P338_I0.9340.93
326_L341_V0.9290.93
197_P247_A0.9250.93
233_I259_A0.9240.93
111_S256_A0.9240.93
58_G78_G0.9240.93
190_V257_L0.9240.93
12_E104_R0.9230.93
39_V276_L0.9190.93
28_R36_Y0.9190.93
205_S223_D0.9150.93
342_F368_N0.9150.93
30_I367_R0.9110.93
17_S21_Q0.9100.93
255_A259_A0.9080.92
147_Q164_G0.8990.92
75_A92_A0.8950.92
63_A120_Q0.8920.92
322_I369_I0.8820.91
106_P109_T0.8800.91
75_A93_A0.8790.91
4_V284_D0.8740.91
361_N368_N0.8740.91
130_I191_A0.8740.91
205_S225_N0.8720.91
227_S242_K0.8700.91
232_V235_K0.8690.91
27_F289_I0.8670.91
62_H76_S0.8590.90
234_K242_K0.8590.90
65_V75_A0.8570.90
3_I31_F0.8560.90
85_T130_I0.8550.90
196_N207_I0.8540.90
330_V341_V0.8480.90
163_F167_S0.8470.90
295_I341_V0.8460.90
205_S226_L0.8440.89
105_D109_T0.8430.89
8_D46_E0.8400.89
90_M94_S0.8360.89
230_A242_K0.8360.89
13_S358_A0.8350.89
69_L99_V0.8350.89
209_G214_A0.8310.89
49_V76_S0.8300.89
90_M145_M0.8300.89
257_L261_L0.8280.89
23_I370_A0.8280.89
283_H315_Y0.8280.89
299_S323_A0.8270.88
287_L318_P0.8250.88
51_A87_F0.8240.88
219_I226_L0.8240.88
288_V312_A0.8160.88
31_F370_A0.8120.88
294_R327_T0.8100.87
4_V282_I0.8100.87
5_I289_I0.8070.87
359_Y363_C0.8070.87
152_K178_G0.8040.87
105_D218_M0.8030.87
361_N364_R0.8010.87
51_A54_A0.7960.87
232_V236_A0.7900.86
17_S54_A0.7900.86
15_S50_E0.7890.86
306_I333_V0.7870.86
277_N281_H0.7860.86
7_P19_V0.7840.86
312_A319_V0.7820.86
67_G99_V0.7780.85
228_H232_V0.7780.85
133_I254_G0.7750.85
30_I370_A0.7730.85
12_E355_F0.7690.85
311_V315_Y0.7690.85
35_Q284_D0.7680.85
107_L166_G0.7670.84
306_I338_I0.7670.84
332_V335_Q0.7670.84
167_S171_L0.7660.84
81_G84_K0.7630.84
110_T163_F0.7610.84
300_I333_V0.7600.84
121_A126_A0.7560.84
188_I260_F0.7530.83
118_I129_I0.7530.83
143_A164_G0.7530.83
176_I179_L0.7480.83
229_Y233_I0.7470.83
190_V263_A0.7470.83
49_V53_I0.7420.82
22_A359_Y0.7420.82
269_I304_V0.7400.82
9_S97_E0.7400.82
69_L109_T0.7390.82
297_S332_V0.7380.82
48_T132_G0.7370.82
58_G80_S0.7340.82
158_G173_D0.7340.82
363_C367_R0.7330.82
219_I223_D0.7330.82
326_L330_V0.7320.82
104_R109_T0.7300.81
27_F366_S0.7300.81
347_S357_G0.7300.81
71_E100_P0.7300.81
135_G193_D0.7290.81
346_T349_G0.7290.81
4_V308_V0.7290.81
136_S250_A0.7280.81
295_I299_S0.7270.81
86_A121_A0.7250.81
22_A363_C0.7240.81
154_C160_E0.7230.81
209_G223_D0.7220.81
300_I336_H0.7190.80
53_I58_G0.7170.80
357_G361_N0.7170.80
164_G171_L0.7170.80
90_M136_S0.7140.80
112_R147_Q0.7130.80
305_P309_A0.7100.80
141_G226_L0.7080.79
206_R223_D0.7080.79
211_Q303_K0.7060.79
68_P73_V0.7050.79
101_A352_D0.7050.79
156_A170_T0.7020.79
343_S346_T0.7010.79
153_L174_I0.7010.79
247_A255_A0.6970.78
155_D161_I0.6960.78
165_G214_A0.6950.78
329_D332_V0.6900.78
297_S327_T0.6880.77
66_T72_K0.6840.77
73_V98_L0.6840.77
334_H368_N0.6820.77
287_L373_L0.6810.77
4_V39_V0.6790.76
348_I361_N0.6770.76
86_A126_A0.6760.76
161_I225_N0.6760.76
129_I257_L0.6760.76
306_I336_H0.6730.76
223_D226_L0.6730.76
120_Q123_E0.6720.76
225_N228_H0.6720.76
173_D236_A0.6720.76
322_I362_I0.6710.76
68_P94_S0.6700.76
20_A23_I0.6690.75
223_D227_S0.6680.75
71_E99_V0.6670.75
59_A124_S0.6640.75
266_K271_I0.6640.75
344_V361_N0.6630.75
351_L355_F0.6610.75
118_I183_L0.6590.74
109_T165_G0.6590.74
16_A20_A0.6590.74
23_I362_I0.6580.74
48_T272_V0.6570.74
106_P139_N0.6560.74
208_F301_H0.6560.74
106_P218_M0.6560.74
145_M257_L0.6480.73
29_E364_R0.6470.73
352_D356_R0.6450.73
176_I236_A0.6440.73
166_G169_N0.6390.72
101_A104_R0.6380.72
365_A369_I0.6360.72
349_G353_E0.6360.72
15_S19_V0.6340.71
330_V334_H0.6310.71
90_M114_T0.6310.71
176_I237_L0.6300.71
247_A254_G0.6280.71
188_I257_L0.6280.71
230_A233_I0.6270.71
37_V284_D0.6260.71
327_T331_G0.6250.70
146_V261_L0.6250.70
94_S137_A0.6240.70
171_L225_N0.6230.70
171_L229_Y0.6220.70
67_G103_K0.6190.70
321_G326_L0.6190.70
201_D206_R0.6180.70
346_T364_R0.6180.70
179_L183_L0.6140.69
198_L252_G0.6130.69
216_E219_I0.6110.69
320_I369_I0.6110.69
94_S111_S0.6100.69
67_G110_T0.6100.69
282_I315_Y0.6090.68
365_A368_N0.6070.68
138_T253_M0.6060.68
338_I341_V0.6050.68
233_I241_V0.6050.68
200_G203_G0.6040.68
80_S85_T0.6030.68
325_S345_L0.6020.68
61_R120_Q0.6010.67
99_V109_T0.5980.67
360_D364_R0.5970.67
110_T138_T0.5960.67
327_T334_H0.5950.67
16_A40_P0.5940.67
126_A186_C0.5940.67
10_Y291_G0.5940.67
241_V259_A0.5900.66
169_N228_H0.5900.66
287_L320_I0.5900.66
199_V205_S0.5890.66
133_I265_L0.5870.66
63_A67_G0.5840.65
212_K303_K0.5830.65
135_G194_V0.5810.65
205_S222_L0.5790.65
366_S369_I0.5790.65
220_V224_N0.5790.65
348_I354_A0.5780.64
207_I210_P0.5770.64
333_V341_V0.5760.64
221_E224_N0.5740.64
21_Q24_E0.5720.64
225_N229_Y0.5720.64
27_F31_F0.5720.64
254_G265_L0.5710.63
4_V37_V0.5710.63
133_I208_F0.5690.63
36_Y370_A0.5690.63
278_L308_V0.5690.63
289_I370_A0.5680.63
141_G233_I0.5670.63
14_L362_I0.5670.63
67_G116_E0.5670.63
317_K339_D0.5660.63
146_V153_L0.5640.63
59_A79_I0.5620.62
5_I38_S0.5610.62
189_R264_E0.5590.62
131_I263_A0.5580.62
48_T87_F0.5580.62
116_E148_A0.5570.62
228_H231_E0.5560.61
340_A372_T0.5560.61
3_I27_F0.5550.61
300_I306_I0.5550.61
348_I372_T0.5550.61
206_R210_P0.5530.61
143_A168_L0.5510.61
211_Q298_Q0.5510.61
250_A268_G0.5460.60
21_Q25_K0.5460.60
114_T137_A0.5450.60
193_D250_A0.5430.60
297_S300_I0.5430.60
5_I27_F0.5420.60
145_M256_A0.5420.60
109_T214_A0.5420.60
171_L228_H0.5420.60
292_E303_K0.5410.59
26_G366_S0.5400.59
348_I351_L0.5400.59
327_T330_V0.5390.59
114_T117_L0.5390.59
9_S298_Q0.5380.59
231_E234_K0.5370.59
208_F211_Q0.5350.59
231_E235_K0.5350.59
49_V88_I0.5350.59
320_I372_T0.5340.58
88_I131_I0.5330.58
193_D268_G0.5330.58
127_T182_R0.5320.58
67_G100_P0.5310.58
147_Q162_G0.5300.58
208_F303_K0.5300.58
344_V362_I0.5290.58
49_V60_E0.5290.58
26_G363_C0.5280.58
114_T145_M0.5260.57
116_E119_L0.5250.57
146_V257_L0.5240.57
345_L348_I0.5240.57
16_A308_V0.5230.57
68_P137_A0.5230.57
143_A225_N0.5220.57
224_N227_S0.5210.57
135_G268_G0.5210.57
278_L282_I0.5210.57
13_S344_V0.5200.56
325_S351_L0.5180.56
145_M254_G0.5180.56
256_A260_F0.5170.56
11_K46_E0.5170.56
165_G168_L0.5170.56
255_A258_M0.5160.56
370_A373_L0.5160.56
369_I373_L0.5160.56
295_I338_I0.5160.56
266_K270_E0.5160.56
133_I192_C0.5160.56
66_T163_F0.5150.56
167_S225_N0.5140.56
66_T73_V0.5140.56
151_A175_D0.5130.55
183_L186_C0.5120.55
143_A163_F0.5120.55
284_D315_Y0.5100.55
344_V365_A0.5090.55
323_A341_V0.5080.55
31_F36_Y0.5080.55
282_I312_A0.5080.55
322_I365_A0.5070.55
161_I172_N0.5060.54
18_E21_Q0.5050.54
141_G168_L0.5040.54
181_P185_D0.5020.54
39_V278_L0.5020.54
244_V255_A0.5020.54
288_V317_K0.5020.54
53_I56_T0.5010.54
147_Q167_S0.5000.54
240_D243_D0.5000.54
99_V104_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwcA 2 0.979 100 0 Contact Map
1to6A 4 0.9738 100 0.027 Contact Map
2r751 1 0.4698 78.4 0.964 Contact Map
1vimA 4 0.4436 63.2 0.968 Contact Map
4hb7A 2 0.5381 56.4 0.969 Contact Map
4h2dA 1 0.3753 53.7 0.97 Contact Map
1eyeA 2 0.5459 53.2 0.97 Contact Map
3jx9A 2 0.4068 51.1 0.97 Contact Map
3f6rA 1 0.336 48 0.971 Contact Map
2hnaA 1 0.3281 47 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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