GREMLIN Database
GARL - 5-keto-4-deoxy-D-glucarate aldolase
UniProt: P23522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10016
Length: 256 (246)
Sequences: 2317 (1755)
Seq/√Len: 111.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_L172_G3.2591.00
102_T160_N3.2021.00
165_A173_I3.0271.00
103_K107_E2.9251.00
160_N163_A2.8501.00
201_H205_R2.8291.00
150_V170_V2.5711.00
13_A18_Q2.5531.00
22_G43_W2.4001.00
162_D205_R2.4001.00
113_T148_I2.2501.00
200_Q229_W2.2441.00
161_V205_R2.2041.00
101_E156_Q2.1831.00
104_E107_E2.1491.00
76_V87_L2.1461.00
79_N109_A2.1401.00
101_E154_S2.0671.00
109_A148_I2.0211.00
118_E143_N1.9761.00
155_Q159_D1.9501.00
48_G58_F1.9021.00
97_I109_A1.8771.00
111_A120_I1.8701.00
158_V198_A1.8671.00
71_A93_Y1.8661.00
155_Q183_A1.8201.00
203_F231_A1.7911.00
207_S232_T1.7631.00
114_R143_N1.7561.00
101_E105_E1.7521.00
186_H192_H1.7411.00
36_L247_T1.6981.00
33_T65_L1.6781.00
189_N192_H1.6741.00
102_T105_E1.6701.00
74_V92_F1.6571.00
214_G233_F1.6531.00
200_Q204_N1.6501.00
107_E111_A1.6281.00
34_E128_R1.6271.00
244_R248_Q1.6261.00
152_I157_G1.6231.00
162_D209_H1.5931.00
224_R228_E1.5651.00
84_I97_I1.5611.00
77_P83_I1.5561.00
162_D165_A1.5341.00
110_V167_T1.5181.00
166_A209_H1.5151.00
227_L234_V1.5091.00
105_E108_L1.5031.00
186_H189_N1.4941.00
161_V165_A1.4761.00
103_K167_T1.4701.00
54_D57_T1.4701.00
156_Q160_N1.4651.00
204_N208_A1.4581.00
212_P232_T1.4531.00
25_S33_T1.4481.00
73_V94_N1.4431.00
104_E108_L1.4281.00
100_V150_V1.4271.00
162_D208_A1.4231.00
37_G68_S1.4131.00
137_D141_Q1.4081.00
60_P63_M1.4071.00
186_H194_D1.4051.00
203_F213_S1.4021.00
19_V227_L1.3981.00
158_V161_V1.3951.00
155_Q184_L1.3821.00
141_Q145_N1.3691.00
196_Q225_R1.3641.00
49_E122_G1.3421.00
23_C36_L1.3411.00
159_D201_H1.3261.00
87_L95_F1.3141.00
158_V202_I1.3131.00
102_T156_Q1.3111.00
226_Y229_W1.2940.99
96_L149_L1.2820.99
13_A20_Q1.2750.99
175_V202_I1.2750.99
103_K166_A1.2670.99
32_S243_F1.2580.99
84_I113_T1.2510.99
103_K163_A1.2470.99
108_L112_S1.2420.99
11_K15_A1.2400.99
114_R118_E1.2380.99
202_I206_A1.2290.99
165_A205_R1.2220.99
24_W45_V1.2050.99
106_A170_V1.1980.99
78_T82_V1.1970.99
114_R146_I1.1860.99
107_E167_T1.1840.99
80_E83_I1.1750.99
222_D225_R1.1740.99
79_N105_E1.1710.99
81_P120_I1.1630.99
206_A213_S1.1610.99
101_E157_G1.1600.99
81_P112_S1.1530.99
220_E253_T1.1530.99
134_T248_Q1.1450.99
62_L92_F1.1450.99
242_V247_T1.1430.99
156_Q159_D1.1410.99
72_P93_Y1.1320.99
41_F251_A1.1290.98
53_N61_Q1.1190.98
31_I63_M1.1180.98
152_I173_I1.1160.98
17_K232_T1.1100.98
99_F154_S1.1090.98
225_R229_W1.1070.98
217_A223_A1.0800.98
84_I109_A1.0700.98
100_V109_A1.0680.98
175_V180_L1.0650.98
197_K201_H1.0640.98
12_A16_A1.0550.98
134_T137_D1.0530.98
76_V84_I1.0400.97
37_G65_L1.0390.97
194_D197_K1.0370.97
184_L198_A1.0280.97
197_K200_Q1.0280.97
116_P182_A1.0250.97
193_P197_K1.0220.97
103_K160_N1.0210.97
63_M66_K1.0130.97
168_E211_K1.0110.97
113_T146_I1.0100.97
55_I86_R1.0090.97
45_V96_L1.0070.97
140_A144_K1.0000.97
174_F216_L0.9960.97
157_G160_N0.9900.97
162_D201_H0.9890.97
110_V170_V0.9890.97
124_S127_H0.9740.96
206_A209_H0.9730.96
219_V222_D0.9710.96
213_S232_T0.9600.96
21_I227_L0.9560.96
9_K13_A0.9470.96
59_I90_I0.9470.96
96_L151_Q0.9460.96
59_I63_M0.9450.95
110_V169_G0.9390.95
173_I206_A0.9320.95
231_A234_V0.9270.95
23_C41_F0.9210.95
76_V97_I0.9170.95
242_V246_A0.9100.94
158_V184_L0.9020.94
25_S65_L0.9010.94
48_G86_R0.9010.94
30_P60_P0.9010.94
74_V87_L0.8900.94
58_F87_L0.8890.94
106_A164_I0.8870.94
206_A211_K0.8860.94
245_S248_Q0.8830.94
10_F20_Q0.8820.93
73_V96_L0.8780.93
12_A145_N0.8750.93
118_E168_E0.8750.93
213_S231_A0.8720.93
172_G212_P0.8720.93
41_F247_T0.8710.93
220_E224_R0.8690.93
222_D226_Y0.8670.93
165_A209_H0.8670.93
198_A201_H0.8660.93
161_V202_I0.8620.93
225_R228_E0.8540.92
196_Q200_Q0.8530.92
238_S241_G0.8490.92
84_I112_S0.8490.92
243_F247_T0.8450.92
106_A110_V0.8420.92
249_K253_T0.8340.91
46_L58_F0.8310.91
20_Q43_W0.8310.91
236_V251_A0.8220.91
35_V244_R0.8220.91
237_G250_L0.8190.91
88_L146_I0.8140.90
109_A150_V0.8140.90
161_V201_H0.8140.90
78_T83_I0.8110.90
58_F74_V0.8100.90
41_F250_L0.8080.90
48_G77_P0.8080.90
94_N147_T0.8060.90
215_I231_A0.8060.90
224_R253_T0.8060.90
190_A195_V0.8000.90
205_R208_A0.7970.89
106_A167_T0.7930.89
249_K252_D0.7930.89
155_Q194_D0.7910.89
223_A234_V0.7900.89
155_Q158_V0.7890.89
19_V232_T0.7870.89
138_Y142_S0.7860.89
246_A249_K0.7850.89
10_F147_T0.7850.89
25_S44_L0.7800.88
114_R171_D0.7710.88
152_I161_V0.7700.88
200_Q225_R0.7670.88
17_K207_S0.7560.87
46_L65_L0.7560.87
11_K171_D0.7490.86
73_V147_T0.7420.86
203_F229_W0.7390.86
62_L74_V0.7360.85
27_L32_S0.7320.85
77_P82_V0.7300.85
78_T105_E0.7290.85
226_Y231_A0.7290.85
96_L122_G0.7260.85
203_F207_S0.7250.85
108_L111_A0.7240.84
104_E163_A0.7230.84
96_L172_G0.7220.84
12_A15_A0.7210.84
171_D211_K0.7170.84
201_H204_N0.7080.83
97_I100_V0.7080.83
110_V148_I0.7060.83
150_V173_I0.7040.83
186_H195_V0.7030.83
83_I87_L0.7010.83
218_P238_S0.6940.82
143_N146_I0.6930.82
37_G64_A0.6900.82
141_Q144_K0.6880.81
49_E85_K0.6840.81
24_W174_F0.6800.81
45_V235_A0.6800.81
9_K12_A0.6790.80
122_G132_F0.6790.80
114_R169_G0.6790.80
85_K122_G0.6760.80
43_W235_A0.6700.80
170_V211_K0.6680.79
62_L90_I0.6680.79
37_G44_L0.6670.79
87_L92_F0.6650.79
198_A202_I0.6610.79
172_G211_K0.6600.79
246_A250_L0.6590.78
99_F124_S0.6590.78
33_T61_Q0.6590.78
195_V199_I0.6550.78
125_V130_N0.6510.78
105_E109_A0.6500.78
193_P196_Q0.6490.77
99_F122_G0.6440.77
215_I226_Y0.6400.76
114_R148_I0.6380.76
192_H195_V0.6370.76
107_E118_E0.6370.76
163_A167_T0.6330.76
39_A251_A0.6300.75
56_S60_P0.6300.75
106_A150_V0.6280.75
97_I113_T0.6260.75
137_D140_A0.6260.75
123_V182_A0.6240.75
33_T70_S0.6240.75
47_D75_R0.6230.75
84_I95_F0.6230.75
175_V199_I0.6200.74
122_G151_Q0.6150.74
93_Y145_N0.6150.74
8_N93_Y0.6130.73
66_K93_Y0.6110.73
46_L61_Q0.6100.73
13_A71_A0.6080.73
205_R209_H0.6080.73
174_F235_A0.6070.73
239_D243_F0.6040.72
116_P187_L0.6030.72
79_N108_L0.6020.72
181_A189_N0.5970.71
110_V114_R0.5930.71
8_N145_N0.5930.71
95_F148_I0.5920.71
148_I170_V0.5920.71
204_N207_S0.5910.71
186_H198_A0.5850.70
49_E151_Q0.5850.70
34_E133_G0.5820.69
79_N82_V0.5800.69
79_N112_S0.5800.69
8_N71_A0.5790.69
123_V181_A0.5780.69
172_G233_F0.5760.69
163_A166_A0.5730.68
34_E63_M0.5730.68
30_P63_M0.5710.68
107_E168_E0.5690.68
245_S249_K0.5670.67
34_E129_A0.5650.67
147_T172_G0.5620.67
152_I158_V0.5610.67
228_E252_D0.5610.67
63_M67_G0.5600.67
181_A195_V0.5600.67
65_L70_S0.5580.66
10_F73_V0.5570.66
128_R132_F0.5570.66
72_P92_F0.5570.66
107_E163_A0.5560.66
76_V95_F0.5550.66
27_L61_Q0.5540.66
180_L184_L0.5540.66
166_A205_R0.5540.66
178_S181_A0.5510.65
38_L68_S0.5510.65
19_V234_V0.5500.65
44_L70_S0.5480.65
51_A216_L0.5470.65
32_S35_V0.5450.64
81_P108_L0.5450.64
88_L121_R0.5440.64
97_I150_V0.5440.64
48_G74_V0.5430.64
26_A240_L0.5410.64
177_P215_I0.5400.64
94_N149_L0.5380.63
174_F214_G0.5370.63
184_L194_D0.5360.63
101_E106_A0.5340.63
99_F105_E0.5340.63
25_S32_S0.5340.63
152_I206_A0.5300.62
89_D180_L0.5300.62
72_P168_E0.5290.62
89_D98_P0.5280.62
175_V214_G0.5270.62
34_E37_G0.5270.62
85_K116_P0.5260.62
129_A138_Y0.5250.62
78_T81_P0.5240.61
85_K99_F0.5240.61
85_K182_A0.5240.61
28_S53_N0.5220.61
85_K138_Y0.5210.61
85_K115_Y0.5190.61
165_A206_A0.5180.61
161_V173_I0.5160.60
196_Q226_Y0.5160.60
223_A236_V0.5120.60
136_A140_A0.5090.59
106_A169_G0.5020.58
224_R229_W0.5020.58
49_E132_F0.5010.58
46_L74_V0.5010.58
24_W43_W0.5000.58
53_N57_T0.5000.58
237_G242_V0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dxeA 5 0.9883 100 0.278 Contact Map
2v5jA 5 1 100 0.284 Contact Map
2vwsA 5 0.9961 100 0.296 Contact Map
4tv5A 5 0.9375 100 0.302 Contact Map
4mf4A 5 0.9805 100 0.311 Contact Map
3qz6A 5 0.9727 100 0.312 Contact Map
1izcA 5 0.9922 100 0.321 Contact Map
4l80A 5 0.9102 100 0.566 Contact Map
1sgjA 3 0.8008 100 0.583 Contact Map
3qllA 3 0.7461 100 0.596 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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