GREMLIN Database
FECR - Protein FecR
UniProt: P23485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10292
Length: 317 (292)
Sequences: 6210 (5388)
Seq/√Len: 315.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_D166_R3.7931.00
132_N154_E3.4091.00
183_E199_Q3.0311.00
178_T203_E2.9181.00
147_T171_L2.8671.00
129_L137_A2.8181.00
138_D149_R2.7591.00
40_Y47_Q2.7461.00
29_S32_Q2.7241.00
158_T183_E2.5671.00
201_A215_I2.4321.00
203_E213_K2.4211.00
197_V218_A2.3311.00
120_R128_L2.2811.00
253_P256_E2.2591.00
128_L158_T2.2411.00
252_K256_E2.1901.00
39_W46_N2.1831.00
203_E215_I2.1741.00
136_A152_Y2.1681.00
156_A183_E2.1611.00
204_V222_L2.0751.00
85_G88_L2.0491.00
22_V32_Q2.0111.00
217_N220_E2.0021.00
169_R178_T1.9981.00
251_D279_R1.9891.00
154_E185_T1.9741.00
115_K134_Q1.9561.00
258_I271_C1.9401.00
201_A217_N1.8881.00
255_G276_A1.8771.00
120_R130_T1.8591.00
196_D221_S1.8331.00
194_Q221_S1.8111.00
28_V36_W1.8011.00
187_R260_T1.7851.00
169_R176_Q1.7741.00
149_R171_L1.7731.00
261_L292_I1.7701.00
196_D235_L1.7481.00
180_L203_E1.7451.00
180_L215_I1.7391.00
288_N291_A1.6801.00
28_V32_Q1.6801.00
171_L176_Q1.6741.00
81_H84_K1.6511.00
220_E234_P1.6511.00
111_Y139_V1.6321.00
195_L202_V1.6191.00
180_L201_A1.6121.00
246_I283_T1.6121.00
222_L230_G1.6101.00
249_F260_T1.5861.00
249_F257_V1.5821.00
162_D165_Q1.5671.00
175_G224_F1.5571.00
33_E37_Q1.5551.00
297_A302_V1.5531.00
297_A304_I1.5121.00
134_Q152_Y1.5081.00
47_Q51_Q1.4871.00
116_G133_T1.4831.00
43_D46_N1.4781.00
154_E187_R1.4751.00
127_S159_T1.4711.00
177_L195_L1.4661.00
158_T199_Q1.4571.00
252_K257_V1.4551.00
290_D306_S1.4531.00
177_L186_V1.4401.00
220_E232_V1.4381.00
262_T268_V1.4381.00
197_V202_V1.4321.00
195_L216_V1.4231.00
173_R188_Q1.4171.00
270_R310_Y1.4101.00
221_S233_K1.4091.00
178_T205_L1.4001.00
110_D136_A1.3981.00
23_L28_V1.3851.00
20_Y36_W1.3831.00
129_L155_I1.3761.00
271_C276_A1.3701.00
273_P276_A1.3681.00
198_Q240_T1.3531.00
145_Q169_R1.3511.00
175_G193_T1.3381.00
156_A243_T1.3181.00
306_S311_W1.3131.00
148_V157_I1.3071.00
130_T158_T1.3051.00
23_L50_W1.2891.00
110_D138_D1.2881.00
23_L36_W1.2841.00
112_R136_A1.2631.00
111_Y121_Q1.2611.00
118_V287_K1.2571.00
108_R138_D1.2571.00
253_P277_G1.2551.00
19_W36_W1.2501.00
79_R83_M1.2501.00
156_A198_Q1.2401.00
265_R290_D1.2351.00
114_A117_T1.2321.00
42_Q46_N1.2311.00
45_D48_W1.2301.00
241_S248_S1.2011.00
122_Q128_L1.2001.00
28_V33_E1.2001.00
258_I269_L1.1981.00
150_L155_I1.1841.00
20_Y24_S1.1791.00
186_V195_L1.1781.00
221_S239_S1.1761.00
34_A38_Q1.1751.00
130_T243_T1.1731.00
194_Q223_Q1.1731.00
205_L213_K1.1681.00
160_A179_A1.1611.00
132_N242_W1.1521.00
255_G277_G1.1501.00
161_K199_Q1.1451.00
249_F252_K1.1421.00
246_I285_P1.1411.00
183_E198_Q1.1351.00
113_T117_T1.1281.00
252_K260_T1.1251.00
248_S283_T1.1161.00
84_K87_L1.1061.00
30_P34_A1.1021.00
127_S160_A1.0981.00
196_D239_S1.0971.00
278_L301_P1.0951.00
32_Q35_R1.0931.00
161_K179_A1.0891.00
265_R289_T1.0711.00
268_V310_Y1.0701.00
46_N50_W1.0661.00
125_D146_R1.0661.00
214_R222_L1.0641.00
124_E139_V1.0631.00
146_R168_F1.0621.00
175_G204_V1.0561.00
179_A182_T1.0501.00
122_Q126_G1.0491.00
133_T264_Y1.0471.00
147_T169_R1.0431.00
159_T168_F1.0301.00
260_T263_R1.0301.00
182_T202_V1.0261.00
80_R84_K1.0221.00
21_A25_G1.0201.00
26_E32_Q1.0191.00
126_G160_A1.0191.00
37_Q41_E1.0131.00
257_V280_L1.0111.00
148_V168_F1.0111.00
167_P178_T1.0081.00
238_E250_S1.0061.00
31_Q34_A0.9941.00
290_D294_N0.9921.00
259_A262_T0.9801.00
177_L184_F0.9711.00
80_R83_M0.9691.00
308_T311_W0.9671.00
84_K88_L0.9601.00
258_I262_T0.9511.00
85_G89_L0.9501.00
118_V245_D0.9451.00
162_D167_P0.9441.00
51_Q54_E0.9351.00
127_S141_F0.9351.00
221_S235_L0.9331.00
152_Y190_D0.9231.00
25_G28_V0.9221.00
180_L200_H0.9201.00
294_N297_A0.9181.00
284_F292_I0.9141.00
17_S21_A0.9111.00
272_D275_V0.9091.00
115_K266_N0.9081.00
82_V85_G0.9061.00
264_Y286_L0.9061.00
19_W28_V0.9041.00
30_P33_E0.9041.00
142_D145_Q0.9031.00
86_L89_L0.8961.00
307_I310_Y0.8961.00
197_V216_V0.8941.00
193_T224_F0.8921.00
44_Q47_Q0.8881.00
296_I302_V0.8861.00
295_V299_T0.8811.00
137_A148_V0.8801.00
185_T196_D0.8801.00
172_T193_T0.8771.00
271_C275_V0.8741.00
118_V130_T0.8731.00
31_Q35_R0.8691.00
123_L129_L0.8681.00
157_I184_F0.8681.00
88_L91_G0.8631.00
280_L300_L0.8571.00
36_W50_W0.8521.00
200_H218_A0.8511.00
140_R149_R0.8511.00
127_S146_R0.8501.00
23_L33_E0.8501.00
69_S72_L0.8471.00
90_L93_G0.8421.00
79_R82_V0.8411.00
270_R313_N0.8391.00
20_Y53_V0.8371.00
176_Q205_L0.8361.00
156_A199_Q0.8331.00
284_F295_V0.8261.00
113_T134_Q0.8201.00
170_V184_F0.8171.00
48_W52_Q0.8101.00
172_T186_V0.8081.00
179_A200_H0.8041.00
76_R80_R0.8001.00
88_L92_A0.7991.00
96_W100_Q0.7991.00
36_W40_Y0.7981.00
257_V292_I0.7981.00
38_Q42_Q0.7971.00
50_W57_R0.7971.00
94_G98_L0.7951.00
240_T243_T0.7941.00
282_G299_T0.7931.00
159_T182_T0.7881.00
253_P279_R0.7881.00
294_N298_Q0.7881.00
297_A303_K0.7861.00
247_L286_L0.7851.00
214_R232_V0.7811.00
222_L229_F0.7811.00
150_L170_V0.7801.00
115_K133_T0.7791.00
53_V56_L0.7751.00
192_F223_Q0.7741.00
172_T177_L0.7731.00
247_L264_Y0.7720.99
129_L157_I0.7640.99
18_H22_V0.7640.99
17_S53_V0.7610.99
157_I168_F0.7610.99
161_K180_L0.7590.99
177_L202_V0.7580.99
46_N49_A0.7570.99
251_D281_S0.7560.99
174_Q193_T0.7560.99
172_T175_G0.7560.99
49_A53_V0.7560.99
141_F166_R0.7560.99
184_F202_V0.7540.99
235_L239_S0.7480.99
114_A133_T0.7480.99
189_Q192_F0.7460.99
87_L90_L0.7460.99
172_T188_Q0.7460.99
124_E141_F0.7430.99
267_G289_T0.7430.99
216_V222_L0.7430.99
113_T133_T0.7420.99
111_Y119_S0.7390.99
170_V186_V0.7390.99
267_G306_S0.7380.99
141_F146_R0.7370.99
113_T119_S0.7360.99
49_A52_Q0.7350.99
265_R292_I0.7340.99
40_Y50_W0.7340.99
253_P257_V0.7260.99
78_T82_V0.7180.99
146_R167_P0.7140.99
68_A72_L0.7130.99
198_Q243_T0.7080.99
113_T135_S0.7060.99
278_L300_L0.7060.99
134_Q263_R0.7040.99
295_V298_Q0.7030.99
256_E259_A0.6990.99
185_T198_Q0.6970.99
77_L81_H0.6910.99
195_L204_V0.6910.99
77_L80_R0.6880.99
67_V71_A0.6860.99
147_T176_Q0.6840.99
157_I170_V0.6830.99
32_Q36_W0.6810.99
181_G199_Q0.6770.99
254_L302_V0.6720.99
196_D240_T0.6690.99
37_Q40_Y0.6690.99
242_W245_D0.6680.99
133_T242_W0.6660.99
180_L197_V0.6650.98
107_L110_D0.6640.98
34_A37_Q0.6630.98
261_L269_L0.6570.98
225_S228_E0.6550.98
255_G259_A0.6550.98
113_T116_G0.6540.98
201_A218_A0.6540.98
216_V220_E0.6530.98
39_W43_D0.6510.98
293_L304_I0.6510.98
35_R38_Q0.6480.98
133_T263_R0.6450.98
179_A183_E0.6440.98
167_P180_L0.6440.98
78_T81_H0.6440.98
159_T179_A0.6430.98
187_R192_F0.6380.98
118_V264_Y0.6380.98
175_G195_L0.6380.98
92_A95_G0.6360.98
93_G97_Q0.6360.98
265_R312_I0.6360.98
142_D166_R0.6350.98
57_R61_G0.6340.98
188_Q193_T0.6310.98
204_V224_F0.6300.98
131_L155_I0.6290.98
163_A166_R0.6290.98
183_E243_T0.6290.98
83_M86_L0.6270.98
19_W23_L0.6270.98
191_N226_A0.6260.98
307_I312_I0.6240.98
97_Q100_Q0.6240.98
41_E47_Q0.6230.98
297_A301_P0.6220.98
275_V302_V0.6220.98
156_A185_T0.6170.98
133_T260_T0.6130.97
265_R293_L0.6120.97
43_D50_W0.6120.97
161_K200_H0.6110.97
135_S189_Q0.6090.97
94_G100_Q0.6070.97
189_Q263_R0.6020.97
113_T118_V0.6020.97
19_W22_V0.6000.97
97_Q101_S0.5990.97
94_G97_Q0.5960.97
135_S155_I0.5950.97
60_L63_V0.5940.97
170_V182_T0.5900.97
247_L257_V0.5900.97
132_N185_T0.5880.97
62_G65_G0.5880.97
267_G311_W0.5860.97
245_D286_L0.5860.97
275_V278_L0.5840.97
118_V286_L0.5830.97
127_S157_I0.5820.97
52_Q56_L0.5820.97
39_W50_W0.5810.97
64_P72_L0.5810.97
179_A184_F0.5810.97
95_G99_W0.5810.97
148_V179_A0.5800.96
118_V132_N0.5780.96
170_V197_V0.5770.96
197_V217_N0.5750.96
113_T131_L0.5730.96
95_G98_L0.5700.96
116_G134_Q0.5680.96
182_T197_V0.5680.96
114_A134_Q0.5670.96
40_Y43_D0.5650.96
174_Q188_Q0.5630.96
18_H21_A0.5620.96
278_L302_V0.5610.96
38_Q41_E0.5590.96
182_T199_Q0.5580.96
170_V179_A0.5570.96
282_G295_V0.5570.96
262_T266_N0.5570.96
98_L101_S0.5560.96
23_L37_Q0.5560.96
47_Q50_W0.5550.95
124_E127_S0.5540.95
129_L148_V0.5540.95
292_I296_I0.5540.95
64_P67_V0.5540.95
143_A166_R0.5540.95
93_G96_W0.5530.95
207_A211_A0.5520.95
179_A197_V0.5500.95
109_A136_A0.5460.95
19_W39_W0.5440.95
177_L216_V0.5430.95
179_A199_Q0.5430.95
127_S168_F0.5430.95
36_W53_V0.5400.95
296_I300_L0.5400.95
44_Q50_W0.5400.95
241_S246_I0.5390.95
33_E39_W0.5380.95
137_A155_I0.5380.95
113_T132_N0.5360.95
135_S150_L0.5360.95
155_I168_F0.5350.95
253_P258_I0.5340.94
262_T293_L0.5330.94
272_D276_A0.5270.94
141_F148_V0.5210.94
124_E129_L0.5200.94
40_Y51_Q0.5200.94
81_H85_G0.5200.94
63_V66_D0.5190.94
269_L293_L0.5180.94
127_S179_A0.5170.93
17_S20_Y0.5160.93
91_G94_G0.5160.93
185_T242_W0.5160.93
235_L240_T0.5160.93
264_Y282_G0.5120.93
307_I311_W0.5120.93
189_Q194_Q0.5120.93
161_K182_T0.5110.93
276_A279_R0.5100.93
267_G309_R0.5100.93
76_R79_R0.5100.93
174_Q226_A0.5090.93
124_E160_A0.5080.93
250_S281_S0.5080.93
54_E57_R0.5050.93
185_T240_T0.5030.93
179_A218_A0.5020.92
184_F197_V0.5020.92
50_W54_E0.5010.92
239_S243_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m0nA 1 0.6467 100 0.33 Contact Map
4g08A 1 0.2271 99.4 0.806 Contact Map
4ar0A 1 0.3249 98.8 0.852 Contact Map
2y3mA 2 0.2271 98 0.882 Contact Map
3gr5A 2 0.2587 97.8 0.889 Contact Map
3ossD 1 0.2303 97.3 0.899 Contact Map
4e9jA 2 0.2429 97.3 0.899 Contact Map
4jtmA 2 0.2397 97.2 0.9 Contact Map
3ezjA 3 0.2208 97.1 0.901 Contact Map
4av2A 3 0.5489 92.1 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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