HYFB - ECOLI - GREMLIN Contacts

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HYFB - Hydrogenase-4 component B

UniProt:	P23482	Sequences: MDALQLLTWSLILYLFASLASLFLLGLDRLAIKLSGITSLVGGVIGIISGITQLHAGVTLVARFAPPFEFADLTLRMDSLSAFMVLVISLLVVVCSLYSLTYMREYEGKGAAAMGFFMNIFIASMVALLVMDNAFWFIVLFEMMSLSSWFLVIARQDKTSINAGMLYFFIAHAGSVLIMIAFLLMGRESGSLDFASFRTLSLSPGLASAVFLLAFFGFGAKAGMMPLHSWLPRAHPAAPSHASALMSGVMVKIGIFGILKVAMDLLAQTGLPLWWGILVMAIGAISALLGVLYALAEQDIKRLLAWSTVENVGIILLAVGVAMVGLSLHDPLLTVVGLLGALFHLLNHALFKGLLFLGAGAIISRLHTHDMEKMGALAKRMPWTAAACLIGCLAISAIPPLNGFISEWYTWQSLFSLSRVEAVALQLAGPIAMVMLAVTGGLAVMCFVKMYGITFCGAPRSTHAEEAQEVPNTMIVAMLLLAALCVLIALSASWLAPKIMHIAHAFTNTPPATVASGIALVPGTFHTQVTPSLLLLLLLAMPLLPGLYWLWCRSRRAAFRRTGDAWACGYGWENAMAPSGNGVMQPLRVVFSALFRLRQQLDPTLRLNKGLAHVTARAQSTEPFWDERVIRPIVSATQRLAKEIQHLQSGDFRLYCLYVVAALVVLLIAIAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11282
Length:	672 (599)
Sequences:	7284 (4341)
Seq/√Len:	177.4

ECOLI - HYFB NUOL HYCC HYFF HYFD NUOM NUON
BACSU - MRPA MRPD NDHF
HALSA - Q9HRL3 Q9HRT0 Q9HRS9 Q9HRL2 Q9HRL1 Q9HRS8
SULSO - Q97ZA9 Q980G9 Q980G8 Q97ZA6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_D	196_S	4.348	1.00
303_L	371_M	4.148	1.00
127_A	140_L	3.994	1.00
78_D	260_K	3.983	1.00
191_S	196_S	3.650	1.00
368_T	373_K	3.431	1.00
40_L	93_V	3.326	1.00
384_T	469_E	3.215	1.00
134_A	261_V	3.200	1.00
385_A	456_C	3.110	1.00
225_M	285_I	3.010	1.00
298_Q	372_E	2.931	1.00
212_L	216_F	2.866	1.00
153_I	164_G	2.847	1.00
354_L	391_G	2.811	1.00
389_L	451_Y	2.793	1.00
134_A	197_F	2.789	1.00
371_M	454_T	2.749	1.00
85_V	126_V	2.738	1.00
317_L	436_L	2.689	1.00
361_A	470_V	2.646	1.00
258_I	316_L	2.603	1.00
85_V	130_V	2.584	1.00
170_I	229_S	2.584	1.00
388_C	450_M	2.540	1.00
393_L	398_I	2.540	1.00
43_G	90_L	2.525	1.00
378_A	385_A	2.479	1.00
188_E	210_V	2.432	1.00
609_K	613_H	2.427	1.00
344_H	406_S	2.424	1.00
166_L	233_R	2.391	1.00
364_S	468_Q	2.360	1.00
385_A	451_Y	2.348	1.00
158_K	236_P	2.346	1.00
131_M	136_W	2.342	1.00
181_A	217_G	2.304	1.00
184_L	210_V	2.294	1.00
347_N	402_N	2.283	1.00
472_N	476_V	2.230	1.00
464_A	467_A	2.219	1.00
15_L	123_A	2.205	1.00
610_G	614_V	2.189	1.00
87_V	349_A	2.182	1.00
18_S	21_S	2.131	1.00
18_S	22_L	2.121	1.00
304_L	359_A	2.099	1.00
392_C	447_F	2.098	1.00
177_L	216_F	2.068	1.00
251_V	308_T	2.027	1.00
101_T	473_T	2.003	1.00
343_F	406_S	2.000	1.00
319_V	341_A	1.982	1.00
88_I	129_L	1.979	1.00
50_G	54_L	1.963	1.00
191_S	197_F	1.963	1.00
259_L	319_V	1.958	1.00
220_A	227_L	1.947	1.00
208_S	274_W	1.942	1.00
609_K	614_V	1.941	1.00
365_R	381_M	1.923	1.00
205_G	209_A	1.920	1.00
63_R	72_D	1.911	1.00
43_G	47_I	1.910	1.00
363_I	369_H	1.907	1.00
258_I	266_L	1.906	1.00
542_P	546_G	1.882	1.00
198_R	264_D	1.873	1.00
144_M	250_M	1.855	1.00
160_S	236_P	1.854	1.00
590_V	595_F	1.840	1.00
411_W	436_L	1.826	1.00
83_F	346_L	1.820	1.00
40_L	44_V	1.820	1.00
76_R	79_S	1.809	1.00
17_A	38_T	1.793	1.00
381_M	384_T	1.787	1.00
255_I	316_L	1.780	1.00
548_Y	552_C	1.777	1.00
358_G	388_C	1.755	1.00
283_G	320_G	1.750	1.00
92_V	122_I	1.739	1.00
134_A	182_F	1.725	1.00
44_V	48_I	1.719	1.00
180_I	213_L	1.713	1.00
159_T	162_N	1.707	1.00
595_F	600_Q	1.706	1.00
298_Q	370_D	1.699	1.00
43_G	89_S	1.694	1.00
99_S	114_M	1.693	1.00
502_I	506_F	1.685	1.00
36_G	97_L	1.683	1.00
434_V	438_V	1.673	1.00
110_G	113_A	1.657	1.00
375_G	457_G	1.651	1.00
387_A	479_L	1.650	1.00
93_V	97_L	1.646	1.00
284_A	435_M	1.644	1.00
392_C	451_Y	1.637	1.00
532_S	535_L	1.637	1.00
383_W	479_L	1.636	1.00
46_G	85_V	1.612	1.00
299_D	369_H	1.602	1.00
505_A	509_T	1.591	1.00
296_A	591_F	1.591	1.00
376_A	457_G	1.590	1.00
295_L	445_M	1.589	1.00
448_V	452_G	1.585	1.00
580_G	584_M	1.584	1.00
219_G	282_I	1.578	1.00
544_L	548_Y	1.566	1.00
106_Y	155_R	1.560	1.00
124_S	143_M	1.558	1.00
212_L	278_L	1.549	1.00
390_I	482_A	1.542	1.00
63_R	66_P	1.541	1.00
371_M	453_I	1.537	1.00
165_M	169_F	1.532	1.00
588_R	592_S	1.531	1.00
39_S	42_G	1.525	1.00
292_L	595_F	1.522	1.00
430_P	434_V	1.516	1.00
287_A	439_T	1.492	1.00
611_L	614_V	1.491	1.00
596_R	600_Q	1.488	1.00
483_A	487_L	1.466	1.00
211_F	275_W	1.460	1.00
387_A	482_A	1.458	1.00
215_F	279_V	1.455	1.00
594_L	599_Q	1.447	1.00
412_Q	416_S	1.446	1.00
22_L	25_L	1.445	1.00
132_D	195_A	1.440	1.00
285_I	431_I	1.436	1.00
291_V	310_E	1.431	1.00
547_L	551_W	1.425	1.00
377_L	381_M	1.419	1.00
585_Q	589_V	1.414	1.00
307_S	446_C	1.414	1.00
536_L	540_A	1.412	1.00
528_Q	533_L	1.401	1.00
215_F	275_W	1.391	1.00
189_S	197_F	1.386	1.00
270_G	274_W	1.386	1.00
74_T	132_D	1.382	1.00
256_F	260_K	1.381	1.00
538_L	542_P	1.381	1.00
471_P	474_M	1.378	1.00
533_L	536_L	1.376	1.00
506_F	509_T	1.376	1.00
505_A	510_P	1.374	1.00
125_M	250_M	1.374	1.00
366_L	374_M	1.369	1.00
593_A	600_Q	1.368	1.00
529_V	533_L	1.367	1.00
83_F	342_L	1.366	1.00
280_M	432_A	1.360	1.00
71_A	135_F	1.358	1.00
535_L	539_L	1.355	1.00
185_M	197_F	1.355	1.00
259_L	342_L	1.355	1.00
39_S	43_G	1.349	1.00
225_M	289_L	1.349	1.00
411_W	440_G	1.344	1.00
610_G	613_H	1.340	1.00
600_Q	604_T	1.329	1.00
451_Y	456_C	1.313	1.00
81_S	256_F	1.311	1.00
383_W	475_I	1.310	1.00
89_S	126_V	1.305	1.00
65_A	71_A	1.297	1.00
321_V	414_L	1.295	1.00
279_V	320_G	1.294	1.00
546_G	550_L	1.287	1.00
45_I	49_S	1.286	1.00
288_L	435_M	1.286	1.00
500_M	504_H	1.285	1.00
211_F	265_L	1.284	1.00
390_I	486_V	1.283	1.00
596_R	599_Q	1.282	1.00
532_S	536_L	1.280	1.00
365_R	468_Q	1.275	1.00
13_L	17_A	1.273	1.00
194_F	198_R	1.271	1.00
503_A	507_T	1.266	1.00
44_V	47_I	1.266	1.00
101_T	471_P	1.266	1.00
14_Y	18_S	1.263	1.00
344_H	351_F	1.257	1.00
475_I	479_L	1.257	1.00
594_L	598_R	1.256	1.00
78_D	81_S	1.254	1.00
77_M	81_S	1.254	1.00
609_K	612_A	1.251	1.00
184_L	209_A	1.248	1.00
311_N	443_A	1.245	1.00
650_G	655_Y	1.244	1.00
601_L	605_L	1.237	1.00
370_D	373_K	1.233	1.00
380_R	465_E	1.232	1.00
291_V	439_T	1.232	1.00
376_A	459_P	1.229	1.00
87_V	346_L	1.228	1.00
395_I	447_F	1.228	1.00
540_A	544_L	1.227	1.00
43_G	46_G	1.213	1.00
479_L	483_A	1.210	1.00
351_F	403_G	1.210	1.00
74_T	193_D	1.209	1.00
211_F	266_L	1.205	1.00
135_F	192_L	1.204	1.00
400_P	405_I	1.202	1.00
191_S	194_F	1.202	1.00
281_A	285_I	1.194	1.00
380_R	467_A	1.192	1.00
30_L	33_K	1.190	1.00
593_A	596_R	1.188	1.00
580_G	590_V	1.188	1.00
584_M	590_V	1.187	1.00
543_L	547_L	1.185	1.00
579_S	583_V	1.183	1.00
358_G	387_A	1.180	1.00
584_M	588_R	1.178	1.00
15_L	18_S	1.177	1.00
502_I	507_T	1.172	1.00
438_V	442_L	1.172	1.00
121_F	148_S	1.170	1.00
507_T	511_P	1.169	1.00
32_I	36_G	1.167	1.00
498_K	501_H	1.165	1.00
177_L	213_L	1.163	1.00
259_L	341_A	1.162	1.00
182_F	192_L	1.160	1.00
120_I	147_S	1.160	1.00
506_F	510_P	1.156	1.00
544_L	547_L	1.153	1.00
375_G	460_R	1.151	1.00
602_D	606_R	1.144	1.00
27_L	30_L	1.143	1.00
8_T	11_L	1.142	1.00
533_L	537_L	1.141	1.00
389_L	456_C	1.140	1.00
347_N	406_S	1.138	1.00
39_S	122_I	1.135	1.00
196_S	200_L	1.133	1.00
31_A	35_S	1.132	1.00
185_M	210_V	1.125	1.00
398_I	539_L	1.123	1.00
84_M	345_L	1.119	1.00
505_A	508_N	1.117	1.00
482_A	485_C	1.116	1.00
300_I	450_M	1.116	1.00
274_W	277_I	1.113	1.00
181_A	210_V	1.110	1.00
235_H	243_S	1.100	1.00
47_I	90_L	1.098	1.00
507_T	510_P	1.096	1.00
132_D	193_D	1.094	1.00
484_L	488_I	1.093	1.00
277_I	281_A	1.091	1.00
362_I	454_T	1.090	1.00
124_S	147_S	1.087	1.00
292_L	442_L	1.087	1.00
39_S	45_I	1.086	1.00
500_M	503_A	1.086	1.00
298_Q	307_S	1.086	1.00
508_N	511_P	1.082	1.00
77_M	130_V	1.081	1.00
361_A	384_T	1.081	1.00
42_G	89_S	1.080	1.00
477_A	480_L	1.079	1.00
100_L	473_T	1.077	1.00
80_L	342_L	1.077	1.00
536_L	539_L	1.071	1.00
97_L	476_V	1.070	1.00
578_P	582_G	1.067	1.00
258_I	319_V	1.067	1.00
364_S	474_M	1.065	1.00
596_R	601_L	1.065	1.00
179_M	183_L	1.065	1.00
56_A	60_L	1.065	1.00
37_I	41_V	1.063	1.00
94_V	477_A	1.062	1.00
39_S	46_G	1.060	1.00
10_S	45_I	1.059	1.00
547_L	550_L	1.058	1.00
51_I	54_L	1.058	1.00
235_H	251_V	1.057	1.00
411_W	538_L	1.057	1.00
505_A	511_P	1.054	1.00
186_G	192_L	1.054	1.00
278_L	282_I	1.053	1.00
36_G	93_V	1.053	1.00
40_L	43_G	1.049	1.00
500_M	506_F	1.048	1.00
417_L	429_G	1.047	1.00
138_I	179_M	1.046	1.00
497_P	501_H	1.046	1.00
354_L	478_M	1.045	1.00
387_A	478_M	1.039	1.00
121_F	125_M	1.038	1.00
591_F	595_F	1.037	1.00
531_P	535_L	1.036	0.99
288_L	439_T	1.032	0.99
470_V	475_I	1.030	0.99
541_M	545_P	1.029	0.99
66_P	69_E	1.021	0.99
17_A	21_S	1.021	0.99
21_S	35_S	1.021	0.99
618_A	623_P	1.015	0.99
502_I	505_A	1.013	0.99
548_Y	551_W	1.012	0.99
208_S	269_T	1.012	0.99
649_S	654_L	1.011	0.99
409_Y	412_Q	1.010	0.99
314_I	436_L	1.004	0.99
361_A	469_E	1.003	0.99
642_K	645_Q	1.003	0.99
42_G	46_G	0.999	0.99
39_S	51_I	0.998	0.99
44_V	51_I	0.996	0.99
13_L	38_T	0.994	0.99
507_T	512_A	0.992	0.99
539_L	542_P	0.992	0.99
501_H	504_H	0.986	0.99
616_A	619_Q	0.985	0.99
188_E	206_L	0.985	0.99
121_F	250_M	0.984	0.99
43_G	49_S	0.978	0.99
535_L	546_G	0.977	0.99
593_A	597_L	0.975	0.99
609_K	616_A	0.975	0.99
578_P	581_N	0.975	0.99
91_L	353_G	0.974	0.99
651_D	654_L	0.973	0.99
378_A	382_P	0.970	0.99
612_A	615_T	0.970	0.99
582_G	585_Q	0.970	0.99
402_N	485_C	0.968	0.99
497_P	500_M	0.967	0.99
469_E	475_I	0.962	0.99
613_H	616_A	0.958	0.99
42_G	49_S	0.957	0.99
504_H	507_T	0.956	0.99
17_A	119_N	0.954	0.99
11_L	18_S	0.953	0.99
494_W	497_P	0.953	0.99
39_S	49_S	0.952	0.99
594_L	597_L	0.949	0.99
639_R	643_E	0.947	0.99
595_F	598_R	0.946	0.99
87_V	345_L	0.944	0.99
610_G	615_T	0.944	0.99
504_H	511_P	0.941	0.99
36_G	100_L	0.941	0.99
527_T	532_S	0.938	0.99
392_C	396_S	0.938	0.99
531_P	534_L	0.938	0.99
311_N	344_H	0.938	0.99
96_S	118_M	0.937	0.99
638_Q	642_K	0.937	0.99
212_L	275_W	0.937	0.99
291_V	307_S	0.936	0.99
138_I	182_F	0.934	0.99
317_L	432_A	0.933	0.99
276_G	280_M	0.932	0.99
625_W	629_V	0.929	0.99
476_V	480_L	0.925	0.99
385_A	389_L	0.925	0.99
381_M	469_E	0.925	0.99
140_L	143_M	0.924	0.99
186_G	189_S	0.921	0.99
116_F	150_F	0.920	0.99
630_I	633_I	0.919	0.99
470_V	474_M	0.918	0.99
275_W	279_V	0.918	0.99
364_S	470_V	0.917	0.99
208_S	275_W	0.915	0.99
52_T	58_V	0.914	0.99
133_N	136_W	0.912	0.99
111_A	115_G	0.911	0.99
599_Q	603_P	0.909	0.99
41_V	44_V	0.909	0.99
590_V	600_Q	0.905	0.99
10_S	49_S	0.904	0.99
47_I	51_I	0.903	0.99
337_G	413_S	0.901	0.99
389_L	392_C	0.900	0.99
593_A	599_Q	0.899	0.99
643_E	647_L	0.898	0.99
224_M	316_L	0.898	0.99
310_E	443_A	0.897	0.99
18_S	116_F	0.897	0.99
107_E	110_G	0.897	0.99
207_A	269_T	0.894	0.99
27_L	31_A	0.888	0.98
661_A	665_V	0.887	0.98
588_R	595_F	0.887	0.98
580_G	583_V	0.887	0.98
634_V	638_Q	0.886	0.98
207_A	211_F	0.883	0.98
611_L	615_T	0.882	0.98
209_A	212_L	0.879	0.98
208_S	212_L	0.878	0.98
11_L	75_L	0.870	0.98
289_L	293_Y	0.869	0.98
114_M	241_H	0.868	0.98
501_H	507_T	0.868	0.98
534_L	538_L	0.866	0.98
600_Q	603_P	0.863	0.98
551_W	554_S	0.862	0.98
13_L	41_V	0.862	0.98
576_M	580_G	0.860	0.98
148_S	250_M	0.860	0.98
280_M	317_L	0.853	0.98
598_R	601_L	0.852	0.98
576_M	579_S	0.850	0.98
589_V	596_R	0.850	0.98
15_L	22_L	0.849	0.98
627_E	631_R	0.849	0.98
452_G	546_G	0.848	0.98
472_N	479_L	0.847	0.98
537_L	541_M	0.846	0.98
641_A	645_Q	0.843	0.98
81_S	260_K	0.843	0.98
284_A	432_A	0.843	0.98
363_I	374_M	0.841	0.98
595_F	599_Q	0.841	0.98
311_N	446_C	0.841	0.98
184_L	188_E	0.840	0.98
183_L	187_R	0.839	0.98
209_A	213_L	0.837	0.98
378_A	456_C	0.835	0.98
297_E	302_R	0.833	0.98
589_V	593_A	0.833	0.98
611_L	617_R	0.832	0.98
509_T	512_A	0.830	0.98
300_I	374_M	0.829	0.98
121_F	251_V	0.827	0.98
597_L	601_L	0.826	0.98
622_E	626_D	0.826	0.98
631_R	634_V	0.824	0.97
10_S	14_Y	0.822	0.97
388_C	451_Y	0.819	0.97
189_S	200_L	0.819	0.97
35_S	39_S	0.816	0.97
178_I	257_G	0.816	0.97
76_R	132_D	0.816	0.97
621_T	625_W	0.814	0.97
94_V	353_G	0.812	0.97
21_S	25_L	0.811	0.97
28_D	36_G	0.811	0.97
28_D	32_I	0.810	0.97
549_W	553_R	0.809	0.97
461_S	464_A	0.808	0.97
49_S	53_Q	0.807	0.97
9_W	13_L	0.807	0.97
36_G	39_S	0.805	0.97
269_T	275_W	0.803	0.97
480_L	484_L	0.802	0.97
400_P	490_L	0.802	0.97
538_L	546_G	0.800	0.97
600_Q	605_L	0.800	0.97
42_G	45_I	0.800	0.97
184_L	206_L	0.799	0.97
527_T	531_P	0.798	0.97
508_N	512_A	0.798	0.97
593_A	598_R	0.795	0.97
461_S	467_A	0.794	0.97
13_L	45_I	0.794	0.97
77_M	82_A	0.793	0.97
504_H	508_N	0.793	0.97
163_A	236_P	0.792	0.97
30_L	35_S	0.791	0.97
504_H	509_T	0.791	0.97
380_R	459_P	0.791	0.97
101_T	474_M	0.787	0.97
49_S	52_T	0.786	0.97
231_L	243_S	0.786	0.97
95_C	122_I	0.784	0.97
624_F	627_E	0.782	0.97
222_A	249_V	0.782	0.97
408_W	412_Q	0.781	0.97
50_G	53_Q	0.780	0.96
444_V	543_L	0.780	0.96
640_L	644_I	0.780	0.96
204_P	207_A	0.779	0.96
102_Y	240_S	0.778	0.96
441_G	541_M	0.776	0.96
636_A	640_L	0.774	0.96
267_A	338_L	0.774	0.96
539_L	549_W	0.774	0.96
498_K	506_F	0.774	0.96
16_F	20_A	0.773	0.96
174_G	227_L	0.772	0.96
635_S	639_R	0.770	0.96
303_L	449_K	0.770	0.96
550_L	554_S	0.769	0.96
579_S	584_M	0.768	0.96
282_I	285_I	0.764	0.96
500_M	507_T	0.763	0.96
210_V	214_A	0.760	0.96
579_S	582_G	0.760	0.96
545_P	548_Y	0.759	0.96
575_A	578_P	0.759	0.96
76_R	195_A	0.759	0.96
92_V	95_C	0.757	0.96
537_L	542_P	0.757	0.96
56_A	59_T	0.755	0.96
620_S	624_F	0.755	0.96
506_F	511_P	0.755	0.96
503_A	511_P	0.753	0.96
280_M	436_L	0.751	0.96
501_H	505_A	0.751	0.96
526_H	532_S	0.746	0.95
102_Y	369_H	0.746	0.95
125_M	222_A	0.746	0.95
537_L	544_L	0.745	0.95
498_K	502_I	0.744	0.95
575_A	580_G	0.743	0.95
235_H	308_T	0.742	0.95
504_H	510_P	0.740	0.95
542_P	547_L	0.740	0.95
65_A	68_F	0.740	0.95
402_N	488_I	0.738	0.95
388_C	392_C	0.738	0.95
578_P	583_V	0.737	0.95
46_G	50_G	0.736	0.95
362_I	455_F	0.732	0.95
31_A	34_L	0.729	0.95
476_V	479_L	0.729	0.95
647_L	658_Y	0.729	0.95
447_F	450_M	0.728	0.95
30_L	34_L	0.728	0.95
243_S	301_K	0.728	0.95
261_V	264_D	0.727	0.95
384_T	470_V	0.727	0.95
638_Q	664_V	0.727	0.95
503_A	506_F	0.725	0.95
46_G	49_S	0.724	0.95
174_G	220_A	0.723	0.95
274_W	278_L	0.721	0.95
491_S	494_W	0.720	0.95
40_L	46_G	0.720	0.95
285_I	289_L	0.719	0.94
612_A	616_A	0.718	0.94
584_M	591_F	0.715	0.94
584_M	592_S	0.714	0.94
269_T	274_W	0.714	0.94
321_V	337_G	0.714	0.94
11_L	14_Y	0.713	0.94
528_Q	531_P	0.713	0.94
280_M	321_V	0.712	0.94
542_P	554_S	0.712	0.94
284_A	317_L	0.711	0.94
133_N	193_D	0.711	0.94
197_F	261_V	0.710	0.94
283_G	313_G	0.710	0.94
457_G	460_R	0.709	0.94
442_L	445_M	0.708	0.94
215_F	278_L	0.708	0.94
533_L	540_A	0.707	0.94
654_L	657_L	0.705	0.94
609_K	615_T	0.704	0.94
365_R	470_V	0.704	0.94
41_V	45_I	0.702	0.94
383_W	387_A	0.701	0.94
619_Q	623_P	0.700	0.94
185_M	189_S	0.699	0.94
577_A	582_G	0.698	0.94
575_A	579_S	0.696	0.93
624_F	628_R	0.694	0.93
82_A	86_L	0.694	0.93
121_F	171_A	0.693	0.93
577_A	580_G	0.693	0.93
584_M	587_L	0.693	0.93
539_L	543_L	0.692	0.93
14_Y	21_S	0.692	0.93
537_L	552_C	0.691	0.93
581_N	585_Q	0.691	0.93
525_F	528_Q	0.690	0.93
343_F	405_I	0.690	0.93
314_I	440_G	0.689	0.93
452_G	456_C	0.689	0.93
47_I	86_L	0.688	0.93
232_P	306_W	0.688	0.93
134_A	194_F	0.687	0.93
40_L	51_I	0.685	0.93
255_I	279_V	0.685	0.93
53_Q	56_A	0.684	0.93
118_M	242_A	0.683	0.93
528_Q	532_S	0.683	0.93
43_G	86_L	0.680	0.93
588_R	596_R	0.679	0.93
95_C	118_M	0.679	0.93
532_S	542_P	0.679	0.93
28_D	105_E	0.677	0.93
382_P	385_A	0.677	0.93
214_A	261_V	0.676	0.92
225_M	290_G	0.676	0.92
137_F	178_I	0.674	0.92
400_P	404_F	0.674	0.92
580_G	588_R	0.672	0.92
399_P	536_L	0.672	0.92
492_A	495_L	0.672	0.92
133_N	192_L	0.671	0.92
459_P	464_A	0.669	0.92
110_G	156_Q	0.669	0.92
439_T	442_L	0.669	0.92
529_V	532_S	0.668	0.92
540_A	546_G	0.667	0.92
390_I	485_C	0.665	0.92
94_V	480_L	0.665	0.92
36_G	40_L	0.664	0.92
45_I	48_I	0.664	0.92
592_S	595_F	0.664	0.92
32_I	100_L	0.664	0.92
231_L	234_A	0.661	0.92
546_G	549_W	0.660	0.92
646_H	649_S	0.658	0.91
43_G	50_G	0.656	0.91
614_V	617_R	0.656	0.91
293_Y	306_W	0.655	0.91
280_M	320_G	0.655	0.91
505_A	512_A	0.654	0.91
441_G	545_P	0.654	0.91
639_R	646_H	0.653	0.91
89_S	93_V	0.653	0.91
361_A	365_R	0.651	0.91
402_N	406_S	0.651	0.91
499_I	507_T	0.650	0.91
14_Y	17_A	0.650	0.91
543_L	546_G	0.650	0.91
378_A	389_L	0.649	0.91
311_N	314_I	0.649	0.91
474_M	478_M	0.649	0.91
64_F	69_E	0.647	0.91
43_G	52_T	0.647	0.91
310_E	446_C	0.647	0.91
343_F	347_N	0.644	0.91
381_M	467_A	0.644	0.91
224_M	235_H	0.643	0.91
550_L	553_R	0.643	0.91
643_E	646_H	0.642	0.90
378_A	386_A	0.640	0.90
279_V	319_V	0.639	0.90
288_L	292_L	0.638	0.90
303_L	453_I	0.637	0.90
90_L	95_C	0.637	0.90
98_Y	357_L	0.636	0.90
12_I	16_F	0.636	0.90
231_L	235_H	0.636	0.90
74_T	133_N	0.635	0.90
435_M	439_T	0.634	0.90
532_S	550_L	0.633	0.90
117_F	150_F	0.632	0.90
621_T	624_F	0.631	0.90
346_L	492_A	0.631	0.90
623_P	626_D	0.629	0.90
350_L	402_N	0.628	0.89
630_I	634_V	0.628	0.89
219_G	278_L	0.627	0.89
344_H	347_N	0.627	0.89
459_P	467_A	0.627	0.89
208_S	278_L	0.626	0.89
610_G	618_A	0.626	0.89
537_L	549_W	0.626	0.89
49_S	82_A	0.626	0.89
581_N	584_M	0.626	0.89
52_T	57_G	0.625	0.89
236_P	302_R	0.625	0.89
598_R	602_D	0.625	0.89
300_I	363_I	0.624	0.89
218_F	257_G	0.624	0.89
644_I	665_V	0.624	0.89
300_I	454_T	0.622	0.89
97_L	477_A	0.622	0.89
315_I	345_L	0.621	0.89
351_F	446_C	0.621	0.89
128_L	253_I	0.621	0.89
386_A	390_I	0.620	0.89
125_M	129_L	0.619	0.89
350_L	484_L	0.617	0.89
117_F	147_S	0.617	0.89
67_P	70_F	0.616	0.89
14_Y	22_L	0.615	0.88
380_R	461_S	0.615	0.88
81_S	85_V	0.614	0.88
583_V	586_P	0.613	0.88
392_C	395_I	0.613	0.88
222_A	253_I	0.611	0.88
302_R	354_L	0.610	0.88
228_H	306_W	0.610	0.88
652_F	656_C	0.609	0.88
287_A	317_L	0.607	0.88
202_L	207_A	0.606	0.88
161_I	164_G	0.606	0.88
472_N	475_I	0.606	0.88
353_G	481_L	0.606	0.88
549_W	554_S	0.605	0.88
134_A	185_M	0.605	0.88
13_L	21_S	0.605	0.88
664_V	668_I	0.604	0.88
540_A	547_L	0.603	0.88
215_F	219_G	0.603	0.88
35_S	38_T	0.603	0.88
584_M	596_R	0.603	0.88
24_L	30_L	0.601	0.87
386_A	389_L	0.601	0.87
527_T	533_L	0.600	0.87
178_I	217_G	0.600	0.87
531_P	536_L	0.599	0.87
642_K	661_A	0.599	0.87
172_H	175_S	0.598	0.87
616_A	620_S	0.597	0.87
539_L	546_G	0.597	0.87
80_L	259_L	0.596	0.87
348_H	352_K	0.596	0.87
622_E	627_E	0.595	0.87
50_G	82_A	0.594	0.87
577_A	584_M	0.594	0.87
124_S	127_A	0.593	0.87
492_A	496_A	0.593	0.87
41_V	58_V	0.592	0.87
119_N	123_A	0.592	0.87
36_G	43_G	0.592	0.87
25_L	31_A	0.592	0.87
222_A	235_H	0.592	0.87
594_L	601_L	0.590	0.86
281_A	435_M	0.590	0.86
28_D	31_A	0.590	0.86
374_M	377_L	0.589	0.86
90_L	94_V	0.588	0.86
27_L	32_I	0.587	0.86
81_S	130_V	0.587	0.86
532_S	539_L	0.586	0.86
57_G	60_L	0.586	0.86
64_F	67_P	0.585	0.86
190_G	193_D	0.585	0.86
628_R	631_R	0.584	0.86
613_H	618_A	0.584	0.86
578_P	584_M	0.583	0.86
544_L	552_C	0.582	0.86
634_V	637_T	0.581	0.86
499_I	505_A	0.580	0.85
443_A	446_C	0.580	0.85
32_I	40_L	0.580	0.85
580_G	595_F	0.580	0.85
150_F	164_G	0.580	0.85
537_L	548_Y	0.579	0.85
36_G	49_S	0.578	0.85
648_Q	653_R	0.578	0.85
194_F	197_F	0.578	0.85
102_Y	125_M	0.578	0.85
379_K	459_P	0.577	0.85
535_L	538_L	0.576	0.85
127_A	139_V	0.576	0.85
255_I	319_V	0.575	0.85
577_A	583_V	0.574	0.85
125_M	148_S	0.574	0.85
498_K	507_T	0.572	0.85
243_S	308_T	0.571	0.85
51_I	55_H	0.571	0.85
201_S	204_P	0.571	0.85
96_S	119_N	0.570	0.84
535_L	544_L	0.569	0.84
75_L	130_V	0.568	0.84
281_A	431_I	0.568	0.84
86_L	90_L	0.567	0.84
121_F	235_H	0.567	0.84
534_L	541_M	0.566	0.84
82_A	85_V	0.566	0.84
590_V	593_A	0.565	0.84
576_M	583_V	0.564	0.84
11_L	123_A	0.564	0.84
191_S	200_L	0.563	0.84
31_A	112_A	0.562	0.84
314_I	439_T	0.562	0.84
78_D	256_F	0.562	0.84
620_S	629_V	0.562	0.84
102_Y	121_F	0.561	0.84
52_T	55_H	0.561	0.84
40_L	49_S	0.561	0.84
308_T	312_V	0.561	0.84
32_I	35_S	0.561	0.84
596_R	603_P	0.560	0.83
499_I	503_A	0.560	0.83
270_G	276_G	0.559	0.83
243_S	251_V	0.558	0.83
530_T	533_L	0.557	0.83
587_L	591_F	0.557	0.83
287_A	314_I	0.557	0.83
125_M	249_V	0.556	0.83
446_C	449_K	0.555	0.83
626_D	631_R	0.555	0.83
401_L	486_V	0.554	0.83
54_L	57_G	0.554	0.83
547_L	552_C	0.554	0.83
33_K	36_G	0.550	0.82
586_P	590_V	0.549	0.82
51_I	56_A	0.549	0.82
575_A	583_V	0.548	0.82
10_S	18_S	0.548	0.82
542_P	550_L	0.548	0.82
648_Q	655_Y	0.547	0.82
261_V	265_L	0.546	0.82
362_I	377_L	0.546	0.82
148_S	446_C	0.546	0.82
546_G	553_R	0.546	0.82
235_H	248_G	0.544	0.82
583_V	596_R	0.544	0.82
500_M	505_A	0.543	0.82
665_V	669_A	0.543	0.82
528_Q	534_L	0.542	0.81
49_S	54_L	0.542	0.81
644_I	647_L	0.541	0.81
105_E	367_H	0.540	0.81
576_M	591_F	0.540	0.81
589_V	592_S	0.540	0.81
440_G	538_L	0.538	0.81
33_K	40_L	0.538	0.81
310_E	407_E	0.537	0.81
581_N	592_S	0.537	0.81
396_S	543_L	0.536	0.81
384_T	467_A	0.536	0.81
207_A	266_L	0.534	0.80
576_M	584_M	0.534	0.80
411_W	534_L	0.534	0.80
344_H	402_N	0.533	0.80
660_V	664_V	0.532	0.80
62_A	73_L	0.531	0.80
642_K	646_H	0.531	0.80
380_R	464_A	0.530	0.80
651_D	656_C	0.530	0.80
251_V	254_G	0.530	0.80
372_E	453_I	0.530	0.80
578_P	586_P	0.529	0.80
91_L	349_A	0.529	0.80
231_L	251_V	0.527	0.80
541_M	548_Y	0.527	0.80
634_V	644_I	0.527	0.80
102_Y	243_S	0.526	0.79
381_M	470_V	0.525	0.79
29_R	33_K	0.525	0.79
530_T	537_L	0.523	0.79
297_E	306_W	0.522	0.79
595_F	601_L	0.522	0.79
547_L	554_S	0.521	0.79
582_G	586_P	0.521	0.79
645_Q	650_G	0.520	0.79
55_H	59_T	0.519	0.79
467_A	470_V	0.518	0.78
27_L	35_S	0.517	0.78
499_I	502_I	0.517	0.78
591_F	594_L	0.517	0.78
590_V	598_R	0.516	0.78
352_K	356_F	0.516	0.78
219_G	227_L	0.516	0.78
461_S	465_E	0.516	0.78
340_G	409_Y	0.516	0.78
35_S	119_N	0.515	0.78
525_F	530_T	0.515	0.78
384_T	475_I	0.513	0.78
338_L	342_L	0.513	0.78
632_P	637_T	0.513	0.78
95_C	357_L	0.512	0.78
539_L	548_Y	0.511	0.77
102_Y	301_K	0.511	0.77
581_N	588_R	0.510	0.77
121_F	151_L	0.510	0.77
620_S	623_P	0.509	0.77
300_I	359_A	0.509	0.77
196_S	199_T	0.509	0.77
475_I	478_M	0.509	0.77
92_V	169_F	0.508	0.77
545_P	551_W	0.507	0.77
25_L	112_A	0.507	0.77
635_S	642_K	0.507	0.77
310_E	351_F	0.506	0.77
134_A	265_L	0.506	0.77
167_Y	235_H	0.506	0.77
545_P	553_R	0.506	0.77
13_L	18_S	0.505	0.77
542_P	549_W	0.504	0.77
307_S	449_K	0.504	0.77
374_M	454_T	0.503	0.76
586_P	597_L	0.503	0.76
248_G	308_T	0.502	0.76
300_I	362_I	0.502	0.76
170_I	223_G	0.502	0.76
622_E	625_W	0.502	0.76
656_C	663_L	0.501	0.76
96_S	122_I	0.501	0.76
620_S	625_W	0.501	0.76
577_A	581_N	0.500	0.76
152_V	167_Y	0.500	0.76
24_L	27_L	0.500	0.76
50_G	55_H	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rkoL	1	0.8854	100	0.292	Contact Map
4he8L	1	0.8839	100	0.297	Contact Map
3rkoM	1	0.7158	100	0.387	Contact Map
4he8M	1	0.686	100	0.417	Contact Map
3rkoN	1	0.683	100	0.436	Contact Map
4he8N	1	0.6324	100	0.479	Contact Map
4he8K	1	0.1369	51.1	0.975	Contact Map
3rkoK	1	0.1429	45.9	0.976	Contact Map
3bz1X	1	0.0536	3.1	0.986	Contact Map
2mofA	1	0.0536	2.5	0.987	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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