GREMLIN Database
MUTL - DNA mismatch repair protein MutL
UniProt: P23367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 615 (580)
Sequences: 3907 (2977)
Seq/√Len: 123.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_T59_N8.5091.00
35_L185_V5.4311.00
38_G61_C4.9291.00
113_R141_V4.8841.00
107_R149_D4.6621.00
44_I175_I4.5551.00
235_T293_E4.3801.00
115_A141_V3.4561.00
27_V54_I3.4521.00
468_R565_L3.2721.00
64_K67_E3.1931.00
122_Q135_K3.1111.00
41_R59_N3.0721.00
68_L112_S3.0041.00
120_A139_H2.9891.00
437_R450_E2.9651.00
31_V175_I2.9601.00
4_Q81_A2.9421.00
536_Q540_P2.9261.00
72_L108_L2.8911.00
109_T122_Q2.8081.00
563_R567_S2.7701.00
114_T117_Q2.7491.00
127_G152_Y2.7261.00
68_L121_W2.6761.00
45_D55_R2.6581.00
579_T583_D2.5491.00
272_I288_F2.5451.00
448_L455_I2.5231.00
46_I171_I2.5201.00
48_R52_K2.5061.00
299_V310_V2.4831.00
228_E235_T2.4651.00
53_L146_E2.4491.00
237_R293_E2.3551.00
43_D188_N2.3321.00
26_V150_L2.3301.00
258_V310_V2.3061.00
107_R126_E2.3021.00
513_D525_A2.2941.00
554_P558_A2.2811.00
168_F191_H2.1671.00
441_I460_L2.1591.00
7_P10_L2.1161.00
53_L148_L2.1131.00
458_L581_L2.1091.00
447_A577_A2.1061.00
55_R144_T2.1031.00
445_D568_E2.1001.00
496_E547_A2.0851.00
126_E132_V2.0841.00
69_A134_V2.0741.00
51_A164_E2.0711.00
481_A525_A2.0661.00
515_Q524_R2.0621.00
63_I68_L2.0621.00
230_Q235_T2.0611.00
448_L457_L2.0581.00
111_T137_A2.0531.00
111_T122_Q2.0521.00
314_Q317_L2.0131.00
27_V171_I2.0011.00
5_V73_A2.0001.00
228_E237_R1.9991.00
45_D57_R1.9621.00
47_E53_L1.9591.00
578_I582_A1.9431.00
41_R186_T1.8951.00
593_K597_G1.8831.00
505_S508_A1.8801.00
562_A595_P1.8641.00
28_K32_E1.8421.00
256_C272_I1.8291.00
111_T146_E1.7991.00
604_D607_P1.7981.00
46_I168_F1.7931.00
45_D190_S1.7921.00
195_I198_Q1.7911.00
489_R520_H1.7891.00
503_A506_A1.7761.00
71_A99_L1.7651.00
493_S496_E1.7641.00
229_W325_G1.7631.00
109_T148_L1.7611.00
438_V447_A1.7481.00
508_A513_D1.7451.00
467_L580_L1.7221.00
225_L329_V1.7071.00
501_E516_S1.6901.00
63_I71_A1.6901.00
470_A587_L1.6871.00
70_L73_A1.6781.00
256_C268_I1.6771.00
471_Q583_D1.6671.00
129_D132_V1.6661.00
72_L125_A1.6631.00
70_L76_A1.6621.00
562_A593_K1.6621.00
212_L239_W1.6571.00
112_S121_W1.6561.00
42_I185_V1.6521.00
111_T139_H1.6521.00
258_V312_F1.6511.00
139_H144_T1.6241.00
227_I290_L1.6111.00
461_P562_A1.6091.00
216_C255_Y1.6091.00
500_L521_V1.6081.00
26_V54_I1.6001.00
562_A597_G1.5991.00
65_K117_Q1.5861.00
230_Q233_D1.5821.00
166_T170_H1.5731.00
459_S462_V1.5591.00
207_Q210_R1.5561.00
438_V577_A1.5511.00
236_L321_F1.5441.00
109_T146_E1.5411.00
275_A323_Y1.5281.00
534_N537_I1.5211.00
461_P597_G1.5181.00
449_L458_L1.5151.00
439_L455_I1.5141.00
227_I240_V1.5101.00
584_V590_Q1.5021.00
504_Q508_A1.4961.00
234_L292_L1.4871.00
63_I67_E1.4871.00
173_E177_R1.4701.00
405_Y408_L1.4651.00
72_L110_L1.4581.00
68_L123_A1.4571.00
566_M572_W1.4501.00
65_K121_W1.4491.00
63_I69_A1.4471.00
574_M578_I1.4421.00
68_L110_L1.4311.00
394_Q397_Y1.4211.00
254_Q288_F1.4161.00
454_N602_S1.4041.00
498_S502_K1.4041.00
496_E540_P1.4001.00
573_S576_Q1.3851.00
506_A509_E1.3841.00
461_P595_P1.3821.00
88_A297_H1.3801.00
48_R164_E1.3771.00
466_W587_L1.3751.00
51_A161_L1.3651.00
523_I539_I1.3601.00
401_Q405_Y1.3591.00
80_I85_D1.3591.00
246_T284_Q1.3501.00
212_L289_V1.3491.00
92_L260_G1.3471.00
43_D190_S1.3461.00
442_V448_L1.3431.00
274_Q323_Y1.3391.00
444_S571_Q1.3291.00
27_V31_V1.3221.00
497_K521_V1.3171.00
270_H319_H1.3081.00
272_I326_V1.3061.00
584_V587_L1.3051.00
358_A361_N1.3021.00
489_R522_T1.3021.00
127_G153_N1.2941.00
464_E468_R1.2911.00
188_N198_Q1.2901.00
31_V44_I1.2881.00
441_I572_W1.2861.00
238_G290_L1.2851.00
583_D586_R1.2731.00
204_E211_R1.2711.00
363_F366_P1.2681.00
471_Q475_G1.2651.00
265_D315_S1.2641.00
566_M580_L1.2621.00
559_Q563_R1.2621.00
366_P370_E1.2581.00
465_R595_P1.2561.00
544_G548_K1.2551.00
458_L463_A1.2551.00
460_L572_W1.2511.00
461_P464_E1.2430.99
237_R291_Y1.2430.99
102_I147_V1.2420.99
100_A104_S1.2400.99
35_L92_L1.2330.99
447_A460_L1.2280.99
553_E557_I1.2260.99
229_W321_F1.2120.99
443_H454_N1.2100.99
31_V178_I1.2100.99
461_P593_K1.2100.99
175_I187_I1.2100.99
441_I577_A1.2100.99
8_P12_N1.2050.99
236_L292_L1.2020.99
172_D189_L1.1980.99
390_W394_Q1.1960.99
111_T120_A1.1950.99
461_P465_R1.1930.99
555_G559_Q1.1920.99
35_L182_R1.1820.99
537_I541_E1.1810.99
496_E544_G1.1790.99
439_L448_L1.1760.99
298_Q313_H1.1730.99
466_W470_A1.1640.99
439_L442_V1.1630.99
442_V455_I1.1600.99
209_E239_W1.1600.99
65_K136_P1.1580.99
168_F189_L1.1480.99
444_S569_H1.1470.99
120_A138_A1.1460.99
465_R562_A1.1410.99
116_E141_V1.1300.99
8_P129_D1.1280.99
451_R454_N1.1280.99
71_A110_L1.1230.99
391_P394_Q1.1150.99
462_V465_R1.1140.99
570_A576_Q1.1130.99
123_A130_M1.1100.99
465_R593_K1.1100.99
473_T557_I1.1090.99
65_K134_V1.1060.99
168_F196_V1.1060.99
163_T166_T1.1060.99
363_F370_E1.1010.99
574_M577_A1.1010.99
390_W393_A1.0960.99
474_P588_C1.0930.99
124_Y133_T1.0890.99
491_K520_H1.0870.99
69_A130_M1.0810.99
234_L318_V1.0750.99
205_G210_R1.0720.98
399_K404_V1.0690.98
469_Q554_P1.0660.98
295_D298_Q1.0630.98
110_L123_A1.0610.98
10_L83_L1.0580.98
26_V147_V1.0570.98
173_E176_R1.0570.98
64_K114_T1.0560.98
433_Q436_G1.0510.98
241_A287_A1.0490.98
9_Q13_Q1.0470.98
436_G449_L1.0470.98
227_I238_G1.0470.98
390_W396_G1.0440.98
218_T222_E1.0410.98
539_I543_I1.0380.98
31_V187_I1.0370.98
241_A246_T1.0340.98
258_V263_M1.0330.98
292_L321_F1.0310.98
105_V150_L1.0310.98
595_P598_G1.0280.98
435_F438_V1.0240.98
209_E221_L1.0230.98
13_Q83_L1.0220.98
149_D152_Y1.0210.98
468_R564_N1.0210.98
234_L321_F1.0170.98
278_D592_V1.0150.98
124_Y132_V1.0140.98
241_A245_H1.0120.98
269_N288_F1.0120.98
401_Q404_V1.0110.98
324_Q328_S1.0050.98
499_A503_A1.0030.98
441_I461_P1.0010.98
397_Y404_V1.0000.98
558_A561_I0.9990.98
168_F172_D0.9990.98
257_Y291_Y0.9980.98
465_R597_G0.9960.98
202_V211_R0.9950.98
186_T198_Q0.9910.97
406_R409_L0.9900.97
276_C330_L0.9870.97
209_E226_A0.9850.97
303_V311_R0.9840.97
592_V599_L0.9820.97
125_A130_M0.9820.97
472_L557_I0.9800.97
468_R471_Q0.9770.97
172_D176_R0.9770.97
63_I114_T0.9660.97
109_T124_Y0.9660.97
206_G211_R0.9640.97
27_V175_I0.9640.97
457_L601_Q0.9580.97
400_Q405_Y0.9540.97
443_H605_L0.9530.97
398_Q401_Q0.9500.97
190_S195_I0.9490.97
445_D609_I0.9480.97
114_T141_V0.9470.97
113_R118_Q0.9450.97
390_W401_Q0.9450.97
365_E371_P0.9450.97
392_N397_Y0.9390.96
327_L331_Q0.9380.96
225_L240_V0.9370.96
26_V102_I0.9370.96
358_A363_F0.9360.96
328_S332_Q0.9340.96
399_K402_G0.9330.96
365_E368_A0.9310.96
56_I145_L0.9310.96
469_Q473_T0.9300.96
80_I89_I0.9260.96
453_G602_S0.9260.96
55_R146_E0.9230.96
562_A567_S0.9160.96
492_V500_L0.9120.96
365_E370_E0.9110.96
15_A18_E0.9110.96
361_N370_E0.9110.96
229_W328_S0.9100.96
255_Y262_M0.9090.96
499_A547_A0.9080.96
94_F307_K0.9070.96
560_W564_N0.9060.96
593_K598_G0.9050.96
443_H450_E0.9030.96
500_L543_I0.9000.96
360_R368_A0.8970.95
260_G293_E0.8960.95
367_A370_E0.8960.95
5_V11_A0.8950.95
451_R602_S0.8910.95
294_I299_V0.8910.95
483_P525_A0.8890.95
43_D57_R0.8890.95
416_Q420_A0.8880.95
280_L330_L0.8880.95
92_L182_R0.8870.95
442_V608_A0.8860.95
504_Q521_V0.8860.95
468_R472_L0.8820.95
298_Q314_Q0.8810.95
69_A73_A0.8750.95
264_R308_H0.8740.95
110_L145_L0.8730.95
488_L536_Q0.8710.95
266_R270_H0.8690.95
393_A396_G0.8670.95
401_Q407_Q0.8660.95
357_A361_N0.8660.95
461_P470_A0.8650.94
503_A546_L0.8630.94
505_S509_E0.8630.94
208_K291_Y0.8630.94
515_Q522_T0.8610.94
34_S38_G0.8580.94
562_A598_G0.8560.94
400_Q416_Q0.8560.94
472_L561_I0.8550.94
562_A566_M0.8550.94
49_G168_F0.8550.94
364_A367_A0.8530.94
491_K519_Q0.8500.94
108_L125_A0.8490.94
447_A572_W0.8480.94
572_W577_A0.8480.94
160_F312_F0.8470.94
564_N567_S0.8470.94
323_Y327_L0.8470.94
408_L411_T0.8460.94
587_L590_Q0.8450.94
358_A362_H0.8440.94
361_N364_A0.8430.94
362_H367_A0.8430.94
523_I535_L0.8410.94
121_W134_V0.8380.93
47_E52_K0.8380.93
498_S516_S0.8370.93
402_G409_L0.8350.93
441_I447_A0.8330.93
414_P421_P0.8330.93
526_V535_L0.8300.93
178_I187_I0.8290.93
393_A398_Q0.8270.93
240_V326_V0.8260.93
456_S602_S0.8240.93
281_G284_Q0.8230.93
489_R517_D0.8220.93
24_A174_I0.8200.93
395_P401_Q0.8180.93
591_L600_L0.8180.93
394_Q404_V0.8170.93
465_R470_A0.8130.92
51_A158_R0.8120.92
512_I523_I0.8110.92
396_G400_Q0.8100.92
567_S595_P0.8100.92
418_L422_E0.8100.92
281_G609_I0.8090.92
358_A369_R0.8080.92
464_E567_S0.8070.92
395_P398_Q0.8070.92
20_V105_V0.8070.92
68_L71_A0.8060.92
234_L294_I0.8060.92
404_V409_L0.8060.92
366_P371_P0.8050.92
175_I197_R0.8040.92
26_V30_L0.8030.92
94_F97_E0.8020.92
276_C286_P0.8010.92
389_P392_N0.8000.92
364_A368_A0.8000.92
406_R410_Q0.8000.92
223_Q242_D0.7970.92
177_R262_M0.7950.92
390_W398_Q0.7940.92
20_V156_A0.7900.91
44_I56_I0.7890.91
433_Q585_E0.7880.91
21_E311_R0.7880.91
262_M308_H0.7860.91
361_N369_R0.7860.91
401_Q409_L0.7860.91
171_I189_L0.7850.91
462_V599_L0.7840.91
492_V521_V0.7830.91
18_E304_H0.7800.91
270_H274_Q0.7790.91
584_V591_L0.7780.91
67_E71_A0.7780.91
52_K149_D0.7780.91
462_V597_G0.7770.91
92_L181_A0.7760.91
361_N367_A0.7730.90
390_W397_Y0.7730.90
188_N195_I0.7720.90
13_Q104_S0.7710.90
66_D69_A0.7710.90
460_L566_M0.7690.90
497_K516_S0.7680.90
498_S501_E0.7620.90
27_V46_I0.7620.90
236_L290_L0.7620.90
460_L465_R0.7610.90
459_S464_E0.7610.90
100_A103_S0.7600.90
561_I564_N0.7590.90
438_V581_L0.7590.90
582_A585_E0.7590.90
359_G365_E0.7580.90
411_T417_K0.7570.89
401_Q408_L0.7570.89
363_F369_R0.7570.89
413_A418_L0.7560.89
74_R112_S0.7550.89
396_G405_Y0.7520.89
593_K596_P0.7480.89
31_V174_I0.7470.89
361_N365_E0.7460.89
457_L603_V0.7440.89
186_T204_E0.7440.89
27_V30_L0.7430.89
59_N141_V0.7420.89
18_E23_P0.7410.88
300_D307_K0.7400.88
472_L564_N0.7390.88
356_V360_R0.7380.88
445_D460_L0.7380.88
123_A132_V0.7370.88
360_R369_R0.7370.88
320_D324_Q0.7340.88
413_A417_K0.7340.88
513_D524_R0.7340.88
553_E558_A0.7330.88
397_Y408_L0.7320.88
9_Q292_L0.7320.88
445_D605_L0.7320.88
398_Q405_Y0.7300.88
11_A88_A0.7300.88
302_N307_K0.7290.88
447_A461_P0.7290.88
514_F521_V0.7280.88
438_V578_I0.7250.87
436_G585_E0.7240.87
23_P49_G0.7230.87
587_L599_L0.7220.87
165_K169_N0.7190.87
208_K239_W0.7180.87
31_V42_I0.7170.87
223_Q244_N0.7150.87
394_Q398_Q0.7130.86
469_Q558_A0.7130.86
15_A304_H0.7120.86
325_G329_V0.7100.86
467_L587_L0.7100.86
402_G407_Q0.7080.86
391_P396_G0.7080.86
225_L242_D0.7070.86
393_A397_Y0.7070.86
49_G164_E0.7070.86
256_C269_N0.7070.86
526_V531_R0.7060.86
389_P418_L0.7050.86
319_H323_Y0.7040.86
226_A237_R0.7030.86
589_P592_V0.7030.86
461_P566_M0.7010.86
95_R98_A0.6990.85
417_K421_P0.6980.85
14_I18_E0.6980.85
256_C288_F0.6980.85
281_G592_V0.6960.85
251_A273_R0.6960.85
366_P369_R0.6960.85
392_N405_Y0.6950.85
12_N100_A0.6940.85
224_A241_A0.6920.85
402_G405_Y0.6920.85
179_A215_I0.6910.85
462_V562_A0.6910.85
584_V600_L0.6900.85
213_G221_L0.6890.85
554_P560_W0.6890.85
321_F325_G0.6890.85
356_V361_N0.6880.85
392_N402_G0.6880.85
392_N395_P0.6870.84
238_G241_A0.6870.84
568_E597_G0.6870.84
414_P417_K0.6860.84
393_A405_Y0.6830.84
112_S117_Q0.6820.84
271_A275_A0.6810.84
461_P567_S0.6810.84
413_A419_K0.6800.84
267_L315_S0.6800.84
445_D459_S0.6790.84
500_L514_F0.6780.84
365_E369_R0.6780.84
413_A416_Q0.6750.83
418_L421_P0.6750.83
117_Q121_W0.6740.83
403_E408_L0.6740.83
400_Q404_V0.6740.83
47_E193_G0.6730.83
394_Q399_K0.6730.83
220_F287_A0.6720.83
567_S597_G0.6710.83
360_R371_P0.6710.83
396_G399_K0.6700.83
19_V50_G0.6700.83
420_A424_Q0.6690.83
254_Q273_R0.6690.83
367_A371_P0.6670.83
590_Q594_T0.6670.83
391_P408_L0.6670.83
568_E595_P0.6650.82
10_L89_I0.6640.82
3_I112_S0.6630.82
400_Q403_E0.6630.82
362_H369_R0.6620.82
94_F98_A0.6610.82
459_S597_G0.6600.82
241_A276_C0.6600.82
394_Q401_Q0.6600.82
58_D62_G0.6600.82
497_K501_E0.6580.82
389_P398_Q0.6580.82
302_N305_P0.6570.82
562_A568_E0.6570.82
556_N559_Q0.6550.82
356_V359_G0.6550.82
394_Q408_L0.6540.81
113_R116_E0.6530.81
22_R156_A0.6520.81
361_N371_P0.6520.81
438_V574_M0.6510.81
191_H196_V0.6490.81
446_C609_I0.6480.81
231_H321_F0.6480.81
357_A363_F0.6480.81
14_I17_G0.6470.81
395_P399_K0.6470.81
183_F211_R0.6470.81
408_L412_P0.6470.81
226_A238_G0.6460.81
440_T445_D0.6460.81
401_Q410_Q0.6450.81
395_P402_G0.6450.81
348_P356_V0.6440.80
216_C253_I0.6430.80
462_V593_K0.6420.80
449_L581_L0.6410.80
356_V363_F0.6410.80
497_K519_Q0.6410.80
357_A362_H0.6400.80
223_Q226_A0.6400.80
340_L343_E0.6400.80
55_R172_D0.6400.80
417_K420_A0.6390.80
294_I298_Q0.6390.80
126_E129_D0.6380.80
31_V171_I0.6370.80
180_L289_V0.6370.80
396_G403_E0.6360.80
19_V75_H0.6340.79
46_I191_H0.6330.79
37_A61_C0.6330.79
446_C461_P0.6330.79
478_P509_E0.6330.79
566_M595_P0.6320.79
69_A123_A0.6310.79
271_A322_I0.6310.79
391_P397_Y0.6300.79
312_F319_H0.6250.78
390_W405_Y0.6250.78
107_R152_Y0.6250.78
462_V470_A0.6240.78
359_G362_H0.6240.78
247_T253_I0.6240.78
456_S466_W0.6230.78
183_F239_W0.6230.78
389_P401_Q0.6220.78
412_P416_Q0.6220.78
460_L464_E0.6200.78
362_H371_P0.6200.78
389_P400_Q0.6200.78
426_P429_A0.6190.78
178_I181_A0.6190.78
441_I464_E0.6190.78
389_P399_K0.6170.78
585_E588_C0.6170.78
463_A584_V0.6170.78
392_N396_G0.6160.77
469_Q594_T0.6150.77
226_A239_W0.6150.77
113_R138_A0.6150.77
28_K301_V0.6150.77
438_V449_L0.6140.77
27_V44_I0.6140.77
407_Q415_M0.6130.77
216_C287_A0.6120.77
577_A592_V0.6120.77
27_V34_S0.6110.77
409_L413_A0.6110.77
401_Q406_R0.6100.77
409_L421_P0.6100.77
394_Q409_L0.6080.76
251_A285_Q0.6080.76
45_D53_L0.6070.76
397_Y410_Q0.6070.76
553_E556_N0.6060.76
170_H270_H0.6050.76
74_R100_A0.6040.76
160_F482_Q0.6040.76
472_L560_W0.6040.76
17_G304_H0.6030.76
178_I262_M0.6030.76
400_Q407_Q0.6030.76
261_R305_P0.6020.76
217_G584_V0.6010.76
209_E213_G0.6010.76
46_I189_L0.6010.76
410_Q420_A0.5990.75
68_L134_V0.5990.75
414_P419_K0.5960.75
397_Y405_Y0.5960.75
174_I178_I0.5950.75
6_L10_L0.5950.75
402_G415_M0.5940.75
315_S319_H0.5940.75
590_Q599_L0.5940.75
240_V275_A0.5940.75
397_Y412_P0.5920.75
390_W399_K0.5920.75
567_S593_K0.5920.75
360_R363_F0.5920.75
22_R167_E0.5920.75
57_R139_H0.5920.75
362_H370_E0.5910.74
368_A371_P0.5900.74
75_H104_S0.5900.74
517_D520_H0.5900.74
16_A23_P0.5880.74
581_L585_E0.5880.74
604_D608_A0.5860.74
495_E547_A0.5850.74
506_A510_L0.5850.74
594_T597_G0.5840.74
405_Y411_T0.5840.74
177_R308_H0.5820.73
459_S562_A0.5810.73
584_V594_T0.5800.73
108_L145_L0.5790.73
398_Q403_E0.5780.73
540_P544_G0.5780.73
405_Y409_L0.5780.73
103_S125_A0.5770.73
362_H366_P0.5770.73
260_G291_Y0.5760.73
211_R216_C0.5750.72
271_A319_H0.5740.72
397_Y401_Q0.5740.72
38_G115_A0.5730.72
32_E302_N0.5730.72
124_Y135_K0.5720.72
103_S123_A0.5700.72
399_K410_Q0.5690.72
344_P347_A0.5690.72
212_L215_I0.5690.72
417_K423_P0.5680.72
103_S108_L0.5680.72
395_P400_Q0.5670.71
360_R364_A0.5660.71
464_E565_L0.5650.71
390_W413_A0.5650.71
20_V92_L0.5650.71
224_A289_V0.5630.71
394_Q400_Q0.5630.71
187_I312_F0.5620.71
403_E407_Q0.5620.71
261_R307_K0.5620.71
363_F371_P0.5610.71
406_R412_P0.5610.71
507_L539_I0.5610.71
563_R568_E0.5600.70
473_T588_C0.5590.70
253_I257_Y0.5590.70
402_G411_T0.5580.70
392_N398_Q0.5570.70
411_T416_Q0.5570.70
492_V543_I0.5550.70
397_Y403_E0.5550.70
419_K423_P0.5540.70
356_V369_R0.5540.70
451_R456_S0.5540.70
356_V367_A0.5540.70
184_D397_Y0.5530.70
396_G401_Q0.5530.70
584_V599_L0.5530.70
441_I459_S0.5530.70
438_V441_I0.5520.69
554_P557_I0.5510.69
42_I333_Q0.5510.69
23_P304_H0.5510.69
275_A326_V0.5510.69
399_K415_M0.5510.69
175_I189_L0.5510.69
95_R305_P0.5510.69
359_G363_F0.5500.69
204_E207_Q0.5500.69
28_K302_N0.5500.69
566_M597_G0.5500.69
560_W563_R0.5490.69
16_A304_H0.5490.69
556_N560_W0.5490.69
590_Q600_L0.5480.69
405_Y413_A0.5480.69
22_R170_H0.5470.69
12_N28_K0.5470.69
404_V408_L0.5470.69
29_E98_A0.5460.69
390_W395_P0.5450.68
87_E311_R0.5450.68
91_S148_L0.5440.68
32_E178_I0.5440.68
106_S147_V0.5430.68
462_V468_R0.5410.68
94_F300_D0.5410.68
404_V422_E0.5410.68
364_A370_E0.5400.68
411_T415_M0.5390.68
20_V555_G0.5390.68
459_S595_P0.5380.67
97_E259_N0.5380.67
225_L333_Q0.5380.67
181_A260_G0.5380.67
363_F368_A0.5380.67
512_I539_I0.5360.67
568_E609_I0.5350.67
202_V205_G0.5340.67
391_P395_P0.5340.67
98_A307_K0.5330.67
130_M134_V0.5320.67
94_F305_P0.5320.67
545_Y549_Q0.5310.66
127_G149_D0.5310.66
254_Q269_N0.5310.66
20_V101_S0.5310.66
95_R300_D0.5300.66
396_G404_V0.5300.66
79_K94_F0.5290.66
183_F208_K0.5290.66
33_N36_D0.5280.66
40_T184_D0.5280.66
393_A407_Q0.5280.66
562_A565_L0.5270.66
357_A360_R0.5270.66
187_I215_I0.5270.66
95_R307_K0.5270.66
406_R411_T0.5270.66
356_V370_E0.5260.66
460_L590_Q0.5260.66
358_A371_P0.5260.66
17_G305_P0.5250.66
40_T476_E0.5250.66
322_I519_Q0.5250.66
377_T409_L0.5240.65
413_A422_E0.5240.65
19_V302_N0.5230.65
462_V595_P0.5230.65
19_V97_E0.5220.65
316_R320_D0.5220.65
406_R413_A0.5210.65
45_D188_N0.5210.65
445_D567_S0.5210.65
208_K289_V0.5200.65
247_T285_Q0.5200.65
392_N411_T0.5200.65
229_W236_L0.5190.65
432_S452_D0.5190.65
586_R603_V0.5190.65
398_Q404_V0.5190.65
54_I147_V0.5180.65
459_S465_R0.5170.64
402_G410_Q0.5170.64
406_R417_K0.5160.64
461_P569_H0.5160.64
86_L167_E0.5150.64
465_R596_P0.5150.64
466_W469_Q0.5140.64
568_E593_K0.5140.64
337_P340_L0.5140.64
3_I67_E0.5130.64
258_V311_R0.5130.64
348_P365_E0.5120.64
404_V420_A0.5120.64
42_I402_G0.5120.64
236_L496_E0.5110.64
197_R202_V0.5110.64
221_L239_W0.5100.63
358_A365_E0.5090.63
106_S297_H0.5090.63
455_I603_V0.5090.63
358_A366_P0.5090.63
211_R265_D0.5080.63
443_H451_R0.5080.63
231_H324_Q0.5080.63
20_V582_A0.5070.63
447_A459_S0.5070.63
397_Y415_M0.5070.63
443_H466_W0.5060.63
233_D295_D0.5050.63
371_P412_P0.5050.63
26_V106_S0.5030.62
419_K422_E0.5030.62
80_I91_S0.5030.62
562_A569_H0.5030.62
378_P392_N0.5030.62
63_I281_G0.5020.62
398_Q409_L0.5020.62
98_A300_D0.5010.62
470_A473_T0.5010.62
438_V450_E0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b63A 2 0.5382 100 0.529 Contact Map
3h4lA 2 0.535 100 0.529 Contact Map
1h7sA 1 0.4813 100 0.542 Contact Map
4p7aA 2 0.4846 100 0.544 Contact Map
3kdgA 2 0.2976 100 0.702 Contact Map
3ncvA 2 0.2992 100 0.703 Contact Map
4e4wB 1 0.322 100 0.718 Contact Map
3cwvA 1 0.4992 100 0.722 Contact Map
4ipeA 2 0.7886 100 0.74 Contact Map
4ivgA 4 0.665 100 0.75 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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