MUTL - ECOLI - GREMLIN Contacts

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MUTL - DNA mismatch repair protein MutL

UniProt:	P23367	Sequences: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKLKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVCAQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	615 (580)
Sequences:	3907 (2977)
Seq/√Len:	123.6

ECOLI - MUTL
BACSU - MUTL
HALSA - MUTL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_T	59_N	8.509	1.00
35_L	185_V	5.431	1.00
38_G	61_C	4.929	1.00
113_R	141_V	4.884	1.00
107_R	149_D	4.662	1.00
44_I	175_I	4.555	1.00
235_T	293_E	4.380	1.00
115_A	141_V	3.456	1.00
27_V	54_I	3.452	1.00
468_R	565_L	3.272	1.00
64_K	67_E	3.193	1.00
122_Q	135_K	3.111	1.00
41_R	59_N	3.072	1.00
68_L	112_S	3.004	1.00
120_A	139_H	2.989	1.00
437_R	450_E	2.965	1.00
31_V	175_I	2.960	1.00
4_Q	81_A	2.942	1.00
536_Q	540_P	2.926	1.00
72_L	108_L	2.891	1.00
109_T	122_Q	2.808	1.00
563_R	567_S	2.770	1.00
114_T	117_Q	2.749	1.00
127_G	152_Y	2.726	1.00
68_L	121_W	2.676	1.00
45_D	55_R	2.658	1.00
579_T	583_D	2.549	1.00
272_I	288_F	2.545	1.00
448_L	455_I	2.523	1.00
46_I	171_I	2.520	1.00
48_R	52_K	2.506	1.00
299_V	310_V	2.483	1.00
228_E	235_T	2.465	1.00
53_L	146_E	2.449	1.00
237_R	293_E	2.355	1.00
43_D	188_N	2.332	1.00
26_V	150_L	2.330	1.00
258_V	310_V	2.306	1.00
107_R	126_E	2.302	1.00
513_D	525_A	2.294	1.00
554_P	558_A	2.281	1.00
168_F	191_H	2.167	1.00
441_I	460_L	2.159	1.00
7_P	10_L	2.116	1.00
53_L	148_L	2.113	1.00
458_L	581_L	2.109	1.00
447_A	577_A	2.106	1.00
55_R	144_T	2.103	1.00
445_D	568_E	2.100	1.00
496_E	547_A	2.085	1.00
126_E	132_V	2.084	1.00
69_A	134_V	2.074	1.00
51_A	164_E	2.071	1.00
481_A	525_A	2.066	1.00
515_Q	524_R	2.062	1.00
63_I	68_L	2.062	1.00
230_Q	235_T	2.061	1.00
448_L	457_L	2.058	1.00
111_T	137_A	2.053	1.00
111_T	122_Q	2.052	1.00
314_Q	317_L	2.013	1.00
27_V	171_I	2.001	1.00
5_V	73_A	2.000	1.00
228_E	237_R	1.999	1.00
45_D	57_R	1.962	1.00
47_E	53_L	1.959	1.00
578_I	582_A	1.943	1.00
41_R	186_T	1.895	1.00
593_K	597_G	1.883	1.00
505_S	508_A	1.880	1.00
562_A	595_P	1.864	1.00
28_K	32_E	1.842	1.00
256_C	272_I	1.829	1.00
111_T	146_E	1.799	1.00
604_D	607_P	1.798	1.00
46_I	168_F	1.793	1.00
45_D	190_S	1.792	1.00
195_I	198_Q	1.791	1.00
489_R	520_H	1.789	1.00
503_A	506_A	1.776	1.00
71_A	99_L	1.765	1.00
493_S	496_E	1.764	1.00
229_W	325_G	1.763	1.00
109_T	148_L	1.761	1.00
438_V	447_A	1.748	1.00
508_A	513_D	1.745	1.00
467_L	580_L	1.722	1.00
225_L	329_V	1.707	1.00
501_E	516_S	1.690	1.00
63_I	71_A	1.690	1.00
470_A	587_L	1.687	1.00
70_L	73_A	1.678	1.00
256_C	268_I	1.677	1.00
471_Q	583_D	1.667	1.00
129_D	132_V	1.666	1.00
72_L	125_A	1.663	1.00
70_L	76_A	1.662	1.00
562_A	593_K	1.662	1.00
212_L	239_W	1.657	1.00
112_S	121_W	1.656	1.00
42_I	185_V	1.652	1.00
111_T	139_H	1.652	1.00
258_V	312_F	1.651	1.00
139_H	144_T	1.624	1.00
227_I	290_L	1.611	1.00
461_P	562_A	1.609	1.00
216_C	255_Y	1.609	1.00
500_L	521_V	1.608	1.00
26_V	54_I	1.600	1.00
562_A	597_G	1.599	1.00
65_K	117_Q	1.586	1.00
230_Q	233_D	1.582	1.00
166_T	170_H	1.573	1.00
459_S	462_V	1.559	1.00
207_Q	210_R	1.556	1.00
438_V	577_A	1.551	1.00
236_L	321_F	1.544	1.00
109_T	146_E	1.541	1.00
275_A	323_Y	1.528	1.00
534_N	537_I	1.521	1.00
461_P	597_G	1.518	1.00
449_L	458_L	1.515	1.00
439_L	455_I	1.514	1.00
227_I	240_V	1.510	1.00
584_V	590_Q	1.502	1.00
504_Q	508_A	1.496	1.00
234_L	292_L	1.487	1.00
63_I	67_E	1.487	1.00
173_E	177_R	1.470	1.00
405_Y	408_L	1.465	1.00
72_L	110_L	1.458	1.00
68_L	123_A	1.457	1.00
566_M	572_W	1.450	1.00
65_K	121_W	1.449	1.00
63_I	69_A	1.447	1.00
574_M	578_I	1.442	1.00
68_L	110_L	1.431	1.00
394_Q	397_Y	1.421	1.00
254_Q	288_F	1.416	1.00
454_N	602_S	1.404	1.00
498_S	502_K	1.404	1.00
496_E	540_P	1.400	1.00
573_S	576_Q	1.385	1.00
506_A	509_E	1.384	1.00
461_P	595_P	1.382	1.00
88_A	297_H	1.380	1.00
48_R	164_E	1.377	1.00
466_W	587_L	1.375	1.00
51_A	161_L	1.365	1.00
523_I	539_I	1.360	1.00
401_Q	405_Y	1.359	1.00
80_I	85_D	1.359	1.00
246_T	284_Q	1.350	1.00
212_L	289_V	1.349	1.00
92_L	260_G	1.347	1.00
43_D	190_S	1.346	1.00
442_V	448_L	1.343	1.00
274_Q	323_Y	1.339	1.00
444_S	571_Q	1.329	1.00
27_V	31_V	1.322	1.00
497_K	521_V	1.317	1.00
270_H	319_H	1.308	1.00
272_I	326_V	1.306	1.00
584_V	587_L	1.305	1.00
358_A	361_N	1.302	1.00
489_R	522_T	1.302	1.00
127_G	153_N	1.294	1.00
464_E	468_R	1.291	1.00
188_N	198_Q	1.290	1.00
31_V	44_I	1.288	1.00
441_I	572_W	1.286	1.00
238_G	290_L	1.285	1.00
583_D	586_R	1.273	1.00
204_E	211_R	1.271	1.00
363_F	366_P	1.268	1.00
471_Q	475_G	1.265	1.00
265_D	315_S	1.264	1.00
566_M	580_L	1.262	1.00
559_Q	563_R	1.262	1.00
366_P	370_E	1.258	1.00
465_R	595_P	1.256	1.00
544_G	548_K	1.255	1.00
458_L	463_A	1.255	1.00
460_L	572_W	1.251	1.00
461_P	464_E	1.243	0.99
237_R	291_Y	1.243	0.99
102_I	147_V	1.242	0.99
100_A	104_S	1.240	0.99
35_L	92_L	1.233	0.99
447_A	460_L	1.228	0.99
553_E	557_I	1.226	0.99
229_W	321_F	1.212	0.99
443_H	454_N	1.210	0.99
31_V	178_I	1.210	0.99
461_P	593_K	1.210	0.99
175_I	187_I	1.210	0.99
441_I	577_A	1.210	0.99
8_P	12_N	1.205	0.99
236_L	292_L	1.202	0.99
172_D	189_L	1.198	0.99
390_W	394_Q	1.196	0.99
111_T	120_A	1.195	0.99
461_P	465_R	1.193	0.99
555_G	559_Q	1.192	0.99
35_L	182_R	1.182	0.99
537_I	541_E	1.181	0.99
496_E	544_G	1.179	0.99
439_L	448_L	1.176	0.99
298_Q	313_H	1.173	0.99
466_W	470_A	1.164	0.99
439_L	442_V	1.163	0.99
442_V	455_I	1.160	0.99
209_E	239_W	1.160	0.99
65_K	136_P	1.158	0.99
168_F	189_L	1.148	0.99
444_S	569_H	1.147	0.99
120_A	138_A	1.146	0.99
465_R	562_A	1.141	0.99
116_E	141_V	1.130	0.99
8_P	129_D	1.128	0.99
451_R	454_N	1.128	0.99
71_A	110_L	1.123	0.99
391_P	394_Q	1.115	0.99
462_V	465_R	1.114	0.99
570_A	576_Q	1.113	0.99
123_A	130_M	1.110	0.99
465_R	593_K	1.110	0.99
473_T	557_I	1.109	0.99
65_K	134_V	1.106	0.99
168_F	196_V	1.106	0.99
163_T	166_T	1.106	0.99
363_F	370_E	1.101	0.99
574_M	577_A	1.101	0.99
390_W	393_A	1.096	0.99
474_P	588_C	1.093	0.99
124_Y	133_T	1.089	0.99
491_K	520_H	1.087	0.99
69_A	130_M	1.081	0.99
234_L	318_V	1.075	0.99
205_G	210_R	1.072	0.98
399_K	404_V	1.069	0.98
469_Q	554_P	1.066	0.98
295_D	298_Q	1.063	0.98
110_L	123_A	1.061	0.98
10_L	83_L	1.058	0.98
26_V	147_V	1.057	0.98
173_E	176_R	1.057	0.98
64_K	114_T	1.056	0.98
433_Q	436_G	1.051	0.98
241_A	287_A	1.049	0.98
9_Q	13_Q	1.047	0.98
436_G	449_L	1.047	0.98
227_I	238_G	1.047	0.98
390_W	396_G	1.044	0.98
218_T	222_E	1.041	0.98
539_I	543_I	1.038	0.98
31_V	187_I	1.037	0.98
241_A	246_T	1.034	0.98
258_V	263_M	1.033	0.98
292_L	321_F	1.031	0.98
105_V	150_L	1.031	0.98
595_P	598_G	1.028	0.98
435_F	438_V	1.024	0.98
209_E	221_L	1.023	0.98
13_Q	83_L	1.022	0.98
149_D	152_Y	1.021	0.98
468_R	564_N	1.021	0.98
234_L	321_F	1.017	0.98
278_D	592_V	1.015	0.98
124_Y	132_V	1.014	0.98
241_A	245_H	1.012	0.98
269_N	288_F	1.012	0.98
401_Q	404_V	1.011	0.98
324_Q	328_S	1.005	0.98
499_A	503_A	1.003	0.98
441_I	461_P	1.001	0.98
397_Y	404_V	1.000	0.98
558_A	561_I	0.999	0.98
168_F	172_D	0.999	0.98
257_Y	291_Y	0.998	0.98
465_R	597_G	0.996	0.98
202_V	211_R	0.995	0.98
186_T	198_Q	0.991	0.97
406_R	409_L	0.990	0.97
276_C	330_L	0.987	0.97
209_E	226_A	0.985	0.97
303_V	311_R	0.984	0.97
592_V	599_L	0.982	0.97
125_A	130_M	0.982	0.97
472_L	557_I	0.980	0.97
468_R	471_Q	0.977	0.97
172_D	176_R	0.977	0.97
63_I	114_T	0.966	0.97
109_T	124_Y	0.966	0.97
206_G	211_R	0.964	0.97
27_V	175_I	0.964	0.97
457_L	601_Q	0.958	0.97
400_Q	405_Y	0.954	0.97
443_H	605_L	0.953	0.97
398_Q	401_Q	0.950	0.97
190_S	195_I	0.949	0.97
445_D	609_I	0.948	0.97
114_T	141_V	0.947	0.97
113_R	118_Q	0.945	0.97
390_W	401_Q	0.945	0.97
365_E	371_P	0.945	0.97
392_N	397_Y	0.939	0.96
327_L	331_Q	0.938	0.96
225_L	240_V	0.937	0.96
26_V	102_I	0.937	0.96
358_A	363_F	0.936	0.96
328_S	332_Q	0.934	0.96
399_K	402_G	0.933	0.96
365_E	368_A	0.931	0.96
56_I	145_L	0.931	0.96
469_Q	473_T	0.930	0.96
80_I	89_I	0.926	0.96
453_G	602_S	0.926	0.96
55_R	146_E	0.923	0.96
562_A	567_S	0.916	0.96
492_V	500_L	0.912	0.96
365_E	370_E	0.911	0.96
15_A	18_E	0.911	0.96
361_N	370_E	0.911	0.96
229_W	328_S	0.910	0.96
255_Y	262_M	0.909	0.96
499_A	547_A	0.908	0.96
94_F	307_K	0.907	0.96
560_W	564_N	0.906	0.96
593_K	598_G	0.905	0.96
443_H	450_E	0.903	0.96
500_L	543_I	0.900	0.96
360_R	368_A	0.897	0.95
260_G	293_E	0.896	0.95
367_A	370_E	0.896	0.95
5_V	11_A	0.895	0.95
451_R	602_S	0.891	0.95
294_I	299_V	0.891	0.95
483_P	525_A	0.889	0.95
43_D	57_R	0.889	0.95
416_Q	420_A	0.888	0.95
280_L	330_L	0.888	0.95
92_L	182_R	0.887	0.95
442_V	608_A	0.886	0.95
504_Q	521_V	0.886	0.95
468_R	472_L	0.882	0.95
298_Q	314_Q	0.881	0.95
69_A	73_A	0.875	0.95
264_R	308_H	0.874	0.95
110_L	145_L	0.873	0.95
488_L	536_Q	0.871	0.95
266_R	270_H	0.869	0.95
393_A	396_G	0.867	0.95
401_Q	407_Q	0.866	0.95
357_A	361_N	0.866	0.95
461_P	470_A	0.865	0.94
503_A	546_L	0.863	0.94
505_S	509_E	0.863	0.94
208_K	291_Y	0.863	0.94
515_Q	522_T	0.861	0.94
34_S	38_G	0.858	0.94
562_A	598_G	0.856	0.94
400_Q	416_Q	0.856	0.94
472_L	561_I	0.855	0.94
562_A	566_M	0.855	0.94
49_G	168_F	0.855	0.94
364_A	367_A	0.853	0.94
491_K	519_Q	0.850	0.94
108_L	125_A	0.849	0.94
447_A	572_W	0.848	0.94
572_W	577_A	0.848	0.94
160_F	312_F	0.847	0.94
564_N	567_S	0.847	0.94
323_Y	327_L	0.847	0.94
408_L	411_T	0.846	0.94
587_L	590_Q	0.845	0.94
358_A	362_H	0.844	0.94
361_N	364_A	0.843	0.94
362_H	367_A	0.843	0.94
523_I	535_L	0.841	0.94
121_W	134_V	0.838	0.93
47_E	52_K	0.838	0.93
498_S	516_S	0.837	0.93
402_G	409_L	0.835	0.93
441_I	447_A	0.833	0.93
414_P	421_P	0.833	0.93
526_V	535_L	0.830	0.93
178_I	187_I	0.829	0.93
393_A	398_Q	0.827	0.93
240_V	326_V	0.826	0.93
456_S	602_S	0.824	0.93
281_G	284_Q	0.823	0.93
489_R	517_D	0.822	0.93
24_A	174_I	0.820	0.93
395_P	401_Q	0.818	0.93
591_L	600_L	0.818	0.93
394_Q	404_V	0.817	0.93
465_R	470_A	0.813	0.92
51_A	158_R	0.812	0.92
512_I	523_I	0.811	0.92
396_G	400_Q	0.810	0.92
567_S	595_P	0.810	0.92
418_L	422_E	0.810	0.92
281_G	609_I	0.809	0.92
358_A	369_R	0.808	0.92
464_E	567_S	0.807	0.92
395_P	398_Q	0.807	0.92
20_V	105_V	0.807	0.92
68_L	71_A	0.806	0.92
234_L	294_I	0.806	0.92
404_V	409_L	0.806	0.92
366_P	371_P	0.805	0.92
175_I	197_R	0.804	0.92
26_V	30_L	0.803	0.92
94_F	97_E	0.802	0.92
276_C	286_P	0.801	0.92
389_P	392_N	0.800	0.92
364_A	368_A	0.800	0.92
406_R	410_Q	0.800	0.92
223_Q	242_D	0.797	0.92
177_R	262_M	0.795	0.92
390_W	398_Q	0.794	0.92
20_V	156_A	0.790	0.91
44_I	56_I	0.789	0.91
433_Q	585_E	0.788	0.91
21_E	311_R	0.788	0.91
262_M	308_H	0.786	0.91
361_N	369_R	0.786	0.91
401_Q	409_L	0.786	0.91
171_I	189_L	0.785	0.91
462_V	599_L	0.784	0.91
492_V	521_V	0.783	0.91
18_E	304_H	0.780	0.91
270_H	274_Q	0.779	0.91
584_V	591_L	0.778	0.91
67_E	71_A	0.778	0.91
52_K	149_D	0.778	0.91
462_V	597_G	0.777	0.91
92_L	181_A	0.776	0.91
361_N	367_A	0.773	0.90
390_W	397_Y	0.773	0.90
188_N	195_I	0.772	0.90
13_Q	104_S	0.771	0.90
66_D	69_A	0.771	0.90
460_L	566_M	0.769	0.90
497_K	516_S	0.768	0.90
498_S	501_E	0.762	0.90
27_V	46_I	0.762	0.90
236_L	290_L	0.762	0.90
460_L	465_R	0.761	0.90
459_S	464_E	0.761	0.90
100_A	103_S	0.760	0.90
561_I	564_N	0.759	0.90
438_V	581_L	0.759	0.90
582_A	585_E	0.759	0.90
359_G	365_E	0.758	0.90
411_T	417_K	0.757	0.89
401_Q	408_L	0.757	0.89
363_F	369_R	0.757	0.89
413_A	418_L	0.756	0.89
74_R	112_S	0.755	0.89
396_G	405_Y	0.752	0.89
593_K	596_P	0.748	0.89
31_V	174_I	0.747	0.89
361_N	365_E	0.746	0.89
457_L	603_V	0.744	0.89
186_T	204_E	0.744	0.89
27_V	30_L	0.743	0.89
59_N	141_V	0.742	0.89
18_E	23_P	0.741	0.88
300_D	307_K	0.740	0.88
472_L	564_N	0.739	0.88
356_V	360_R	0.738	0.88
445_D	460_L	0.738	0.88
123_A	132_V	0.737	0.88
360_R	369_R	0.737	0.88
320_D	324_Q	0.734	0.88
413_A	417_K	0.734	0.88
513_D	524_R	0.734	0.88
553_E	558_A	0.733	0.88
397_Y	408_L	0.732	0.88
9_Q	292_L	0.732	0.88
445_D	605_L	0.732	0.88
398_Q	405_Y	0.730	0.88
11_A	88_A	0.730	0.88
302_N	307_K	0.729	0.88
447_A	461_P	0.729	0.88
514_F	521_V	0.728	0.88
438_V	578_I	0.725	0.87
436_G	585_E	0.724	0.87
23_P	49_G	0.723	0.87
587_L	599_L	0.722	0.87
165_K	169_N	0.719	0.87
208_K	239_W	0.718	0.87
31_V	42_I	0.717	0.87
223_Q	244_N	0.715	0.87
394_Q	398_Q	0.713	0.86
469_Q	558_A	0.713	0.86
15_A	304_H	0.712	0.86
325_G	329_V	0.710	0.86
467_L	587_L	0.710	0.86
402_G	407_Q	0.708	0.86
391_P	396_G	0.708	0.86
225_L	242_D	0.707	0.86
393_A	397_Y	0.707	0.86
49_G	164_E	0.707	0.86
256_C	269_N	0.707	0.86
526_V	531_R	0.706	0.86
389_P	418_L	0.705	0.86
319_H	323_Y	0.704	0.86
226_A	237_R	0.703	0.86
589_P	592_V	0.703	0.86
461_P	566_M	0.701	0.86
95_R	98_A	0.699	0.85
417_K	421_P	0.698	0.85
14_I	18_E	0.698	0.85
256_C	288_F	0.698	0.85
281_G	592_V	0.696	0.85
251_A	273_R	0.696	0.85
366_P	369_R	0.696	0.85
392_N	405_Y	0.695	0.85
12_N	100_A	0.694	0.85
224_A	241_A	0.692	0.85
402_G	405_Y	0.692	0.85
179_A	215_I	0.691	0.85
462_V	562_A	0.691	0.85
584_V	600_L	0.690	0.85
213_G	221_L	0.689	0.85
554_P	560_W	0.689	0.85
321_F	325_G	0.689	0.85
356_V	361_N	0.688	0.85
392_N	402_G	0.688	0.85
392_N	395_P	0.687	0.84
238_G	241_A	0.687	0.84
568_E	597_G	0.687	0.84
414_P	417_K	0.686	0.84
393_A	405_Y	0.683	0.84
112_S	117_Q	0.682	0.84
271_A	275_A	0.681	0.84
461_P	567_S	0.681	0.84
413_A	419_K	0.680	0.84
267_L	315_S	0.680	0.84
445_D	459_S	0.679	0.84
500_L	514_F	0.678	0.84
365_E	369_R	0.678	0.84
413_A	416_Q	0.675	0.83
418_L	421_P	0.675	0.83
117_Q	121_W	0.674	0.83
403_E	408_L	0.674	0.83
400_Q	404_V	0.674	0.83
47_E	193_G	0.673	0.83
394_Q	399_K	0.673	0.83
220_F	287_A	0.672	0.83
567_S	597_G	0.671	0.83
360_R	371_P	0.671	0.83
396_G	399_K	0.670	0.83
19_V	50_G	0.670	0.83
420_A	424_Q	0.669	0.83
254_Q	273_R	0.669	0.83
367_A	371_P	0.667	0.83
590_Q	594_T	0.667	0.83
391_P	408_L	0.667	0.83
568_E	595_P	0.665	0.82
10_L	89_I	0.664	0.82
3_I	112_S	0.663	0.82
400_Q	403_E	0.663	0.82
362_H	369_R	0.662	0.82
94_F	98_A	0.661	0.82
459_S	597_G	0.660	0.82
241_A	276_C	0.660	0.82
394_Q	401_Q	0.660	0.82
58_D	62_G	0.660	0.82
497_K	501_E	0.658	0.82
389_P	398_Q	0.658	0.82
302_N	305_P	0.657	0.82
562_A	568_E	0.657	0.82
556_N	559_Q	0.655	0.82
356_V	359_G	0.655	0.82
394_Q	408_L	0.654	0.81
113_R	116_E	0.653	0.81
22_R	156_A	0.652	0.81
361_N	371_P	0.652	0.81
438_V	574_M	0.651	0.81
191_H	196_V	0.649	0.81
446_C	609_I	0.648	0.81
231_H	321_F	0.648	0.81
357_A	363_F	0.648	0.81
14_I	17_G	0.647	0.81
395_P	399_K	0.647	0.81
183_F	211_R	0.647	0.81
408_L	412_P	0.647	0.81
226_A	238_G	0.646	0.81
440_T	445_D	0.646	0.81
401_Q	410_Q	0.645	0.81
395_P	402_G	0.645	0.81
348_P	356_V	0.644	0.80
216_C	253_I	0.643	0.80
462_V	593_K	0.642	0.80
449_L	581_L	0.641	0.80
356_V	363_F	0.641	0.80
497_K	519_Q	0.641	0.80
357_A	362_H	0.640	0.80
223_Q	226_A	0.640	0.80
340_L	343_E	0.640	0.80
55_R	172_D	0.640	0.80
417_K	420_A	0.639	0.80
294_I	298_Q	0.639	0.80
126_E	129_D	0.638	0.80
31_V	171_I	0.637	0.80
180_L	289_V	0.637	0.80
396_G	403_E	0.636	0.80
19_V	75_H	0.634	0.79
46_I	191_H	0.633	0.79
37_A	61_C	0.633	0.79
446_C	461_P	0.633	0.79
478_P	509_E	0.633	0.79
566_M	595_P	0.632	0.79
69_A	123_A	0.631	0.79
271_A	322_I	0.631	0.79
391_P	397_Y	0.630	0.79
312_F	319_H	0.625	0.78
390_W	405_Y	0.625	0.78
107_R	152_Y	0.625	0.78
462_V	470_A	0.624	0.78
359_G	362_H	0.624	0.78
247_T	253_I	0.624	0.78
456_S	466_W	0.623	0.78
183_F	239_W	0.623	0.78
389_P	401_Q	0.622	0.78
412_P	416_Q	0.622	0.78
460_L	464_E	0.620	0.78
362_H	371_P	0.620	0.78
389_P	400_Q	0.620	0.78
426_P	429_A	0.619	0.78
178_I	181_A	0.619	0.78
441_I	464_E	0.619	0.78
389_P	399_K	0.617	0.78
585_E	588_C	0.617	0.78
463_A	584_V	0.617	0.78
392_N	396_G	0.616	0.77
469_Q	594_T	0.615	0.77
226_A	239_W	0.615	0.77
113_R	138_A	0.615	0.77
28_K	301_V	0.615	0.77
438_V	449_L	0.614	0.77
27_V	44_I	0.614	0.77
407_Q	415_M	0.613	0.77
216_C	287_A	0.612	0.77
577_A	592_V	0.612	0.77
27_V	34_S	0.611	0.77
409_L	413_A	0.611	0.77
401_Q	406_R	0.610	0.77
409_L	421_P	0.610	0.77
394_Q	409_L	0.608	0.76
251_A	285_Q	0.608	0.76
45_D	53_L	0.607	0.76
397_Y	410_Q	0.607	0.76
553_E	556_N	0.606	0.76
170_H	270_H	0.605	0.76
74_R	100_A	0.604	0.76
160_F	482_Q	0.604	0.76
472_L	560_W	0.604	0.76
17_G	304_H	0.603	0.76
178_I	262_M	0.603	0.76
400_Q	407_Q	0.603	0.76
261_R	305_P	0.602	0.76
217_G	584_V	0.601	0.76
209_E	213_G	0.601	0.76
46_I	189_L	0.601	0.76
410_Q	420_A	0.599	0.75
68_L	134_V	0.599	0.75
414_P	419_K	0.596	0.75
397_Y	405_Y	0.596	0.75
174_I	178_I	0.595	0.75
6_L	10_L	0.595	0.75
402_G	415_M	0.594	0.75
315_S	319_H	0.594	0.75
590_Q	599_L	0.594	0.75
240_V	275_A	0.594	0.75
397_Y	412_P	0.592	0.75
390_W	399_K	0.592	0.75
567_S	593_K	0.592	0.75
360_R	363_F	0.592	0.75
22_R	167_E	0.592	0.75
57_R	139_H	0.592	0.75
362_H	370_E	0.591	0.74
368_A	371_P	0.590	0.74
75_H	104_S	0.590	0.74
517_D	520_H	0.590	0.74
16_A	23_P	0.588	0.74
581_L	585_E	0.588	0.74
604_D	608_A	0.586	0.74
495_E	547_A	0.585	0.74
506_A	510_L	0.585	0.74
594_T	597_G	0.584	0.74
405_Y	411_T	0.584	0.74
177_R	308_H	0.582	0.73
459_S	562_A	0.581	0.73
584_V	594_T	0.580	0.73
108_L	145_L	0.579	0.73
398_Q	403_E	0.578	0.73
540_P	544_G	0.578	0.73
405_Y	409_L	0.578	0.73
103_S	125_A	0.577	0.73
362_H	366_P	0.577	0.73
260_G	291_Y	0.576	0.73
211_R	216_C	0.575	0.72
271_A	319_H	0.574	0.72
397_Y	401_Q	0.574	0.72
38_G	115_A	0.573	0.72
32_E	302_N	0.573	0.72
124_Y	135_K	0.572	0.72
103_S	123_A	0.570	0.72
399_K	410_Q	0.569	0.72
344_P	347_A	0.569	0.72
212_L	215_I	0.569	0.72
417_K	423_P	0.568	0.72
103_S	108_L	0.568	0.72
395_P	400_Q	0.567	0.71
360_R	364_A	0.566	0.71
464_E	565_L	0.565	0.71
390_W	413_A	0.565	0.71
20_V	92_L	0.565	0.71
224_A	289_V	0.563	0.71
394_Q	400_Q	0.563	0.71
187_I	312_F	0.562	0.71
403_E	407_Q	0.562	0.71
261_R	307_K	0.562	0.71
363_F	371_P	0.561	0.71
406_R	412_P	0.561	0.71
507_L	539_I	0.561	0.71
563_R	568_E	0.560	0.70
473_T	588_C	0.559	0.70
253_I	257_Y	0.559	0.70
402_G	411_T	0.558	0.70
392_N	398_Q	0.557	0.70
411_T	416_Q	0.557	0.70
492_V	543_I	0.555	0.70
397_Y	403_E	0.555	0.70
419_K	423_P	0.554	0.70
356_V	369_R	0.554	0.70
451_R	456_S	0.554	0.70
356_V	367_A	0.554	0.70
184_D	397_Y	0.553	0.70
396_G	401_Q	0.553	0.70
584_V	599_L	0.553	0.70
441_I	459_S	0.553	0.70
438_V	441_I	0.552	0.69
554_P	557_I	0.551	0.69
42_I	333_Q	0.551	0.69
23_P	304_H	0.551	0.69
275_A	326_V	0.551	0.69
399_K	415_M	0.551	0.69
175_I	189_L	0.551	0.69
95_R	305_P	0.551	0.69
359_G	363_F	0.550	0.69
204_E	207_Q	0.550	0.69
28_K	302_N	0.550	0.69
566_M	597_G	0.550	0.69
560_W	563_R	0.549	0.69
16_A	304_H	0.549	0.69
556_N	560_W	0.549	0.69
590_Q	600_L	0.548	0.69
405_Y	413_A	0.548	0.69
22_R	170_H	0.547	0.69
12_N	28_K	0.547	0.69
404_V	408_L	0.547	0.69
29_E	98_A	0.546	0.69
390_W	395_P	0.545	0.68
87_E	311_R	0.545	0.68
91_S	148_L	0.544	0.68
32_E	178_I	0.544	0.68
106_S	147_V	0.543	0.68
462_V	468_R	0.541	0.68
94_F	300_D	0.541	0.68
404_V	422_E	0.541	0.68
364_A	370_E	0.540	0.68
411_T	415_M	0.539	0.68
20_V	555_G	0.539	0.68
459_S	595_P	0.538	0.67
97_E	259_N	0.538	0.67
225_L	333_Q	0.538	0.67
181_A	260_G	0.538	0.67
363_F	368_A	0.538	0.67
512_I	539_I	0.536	0.67
568_E	609_I	0.535	0.67
202_V	205_G	0.534	0.67
391_P	395_P	0.534	0.67
98_A	307_K	0.533	0.67
130_M	134_V	0.532	0.67
94_F	305_P	0.532	0.67
545_Y	549_Q	0.531	0.66
127_G	149_D	0.531	0.66
254_Q	269_N	0.531	0.66
20_V	101_S	0.531	0.66
95_R	300_D	0.530	0.66
396_G	404_V	0.530	0.66
79_K	94_F	0.529	0.66
183_F	208_K	0.529	0.66
33_N	36_D	0.528	0.66
40_T	184_D	0.528	0.66
393_A	407_Q	0.528	0.66
562_A	565_L	0.527	0.66
357_A	360_R	0.527	0.66
187_I	215_I	0.527	0.66
95_R	307_K	0.527	0.66
406_R	411_T	0.527	0.66
356_V	370_E	0.526	0.66
460_L	590_Q	0.526	0.66
358_A	371_P	0.526	0.66
17_G	305_P	0.525	0.66
40_T	476_E	0.525	0.66
322_I	519_Q	0.525	0.66
377_T	409_L	0.524	0.65
413_A	422_E	0.524	0.65
19_V	302_N	0.523	0.65
462_V	595_P	0.523	0.65
19_V	97_E	0.522	0.65
316_R	320_D	0.522	0.65
406_R	413_A	0.521	0.65
45_D	188_N	0.521	0.65
445_D	567_S	0.521	0.65
208_K	289_V	0.520	0.65
247_T	285_Q	0.520	0.65
392_N	411_T	0.520	0.65
229_W	236_L	0.519	0.65
432_S	452_D	0.519	0.65
586_R	603_V	0.519	0.65
398_Q	404_V	0.519	0.65
54_I	147_V	0.518	0.65
459_S	465_R	0.517	0.64
402_G	410_Q	0.517	0.64
406_R	417_K	0.516	0.64
461_P	569_H	0.516	0.64
86_L	167_E	0.515	0.64
465_R	596_P	0.515	0.64
466_W	469_Q	0.514	0.64
568_E	593_K	0.514	0.64
337_P	340_L	0.514	0.64
3_I	67_E	0.513	0.64
258_V	311_R	0.513	0.64
348_P	365_E	0.512	0.64
404_V	420_A	0.512	0.64
42_I	402_G	0.512	0.64
236_L	496_E	0.511	0.64
197_R	202_V	0.511	0.64
221_L	239_W	0.510	0.63
358_A	365_E	0.509	0.63
106_S	297_H	0.509	0.63
455_I	603_V	0.509	0.63
358_A	366_P	0.509	0.63
211_R	265_D	0.508	0.63
443_H	451_R	0.508	0.63
231_H	324_Q	0.508	0.63
20_V	582_A	0.507	0.63
447_A	459_S	0.507	0.63
397_Y	415_M	0.507	0.63
443_H	466_W	0.506	0.63
233_D	295_D	0.505	0.63
371_P	412_P	0.505	0.63
26_V	106_S	0.503	0.62
419_K	422_E	0.503	0.62
80_I	91_S	0.503	0.62
562_A	569_H	0.503	0.62
378_P	392_N	0.503	0.62
63_I	281_G	0.502	0.62
398_Q	409_L	0.502	0.62
98_A	300_D	0.501	0.62
470_A	473_T	0.501	0.62
438_V	450_E	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1b63A	2	0.5382	100	0.529	Contact Map
3h4lA	2	0.535	100	0.529	Contact Map
1h7sA	1	0.4813	100	0.542	Contact Map
4p7aA	2	0.4846	100	0.544	Contact Map
3kdgA	2	0.2976	100	0.702	Contact Map
3ncvA	2	0.2992	100	0.703	Contact Map
4e4wB	1	0.322	100	0.718	Contact Map
3cwvA	1	0.4992	100	0.722	Contact Map
4ipeA	2	0.7886	100	0.74	Contact Map
4ivgA	4	0.665	100	0.75	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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