GREMLIN Database
KITH - Thymidine kinase
UniProt: P23331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10994
Length: 205 (181)
Sequences: 2158 (1098)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_C182_C3.8261.00
155_L181_V2.9251.00
182_C185_H2.8111.00
48_K56_S2.6741.00
3_Q137_K2.6161.00
147_C185_H2.5541.00
27_Q57_S2.4891.00
171_V177_R2.3751.00
35_V49_V2.2341.00
98_Y130_Y2.1561.00
146_F185_H2.1261.00
45_G48_K2.1101.00
17_T21_Q2.1001.00
18_A21_Q2.0781.00
119_D169_Q2.0701.00
67_S70_D2.0691.00
23_S33_T2.0101.00
89_C113_C1.9971.00
43_R173_G1.9931.00
23_S85_L1.9781.00
39_E63_N1.9191.00
36_Y71_E1.8691.00
20_L35_V1.8381.00
100_L104_V1.8011.00
69_F107_L1.7991.00
9_S13_A1.7081.00
94_R126_I1.6741.00
19_L85_L1.6651.00
86_V100_L1.6441.00
7_Y139_V1.6301.00
101_S183_R1.6231.00
102_E106_Q1.6231.00
14_G21_Q1.5701.00
102_E187_K1.5681.00
65_N93_T1.5300.99
129_Q133_A1.5200.99
158_D162_R1.5110.99
48_K58_P1.5080.99
4_L104_V1.5020.99
94_R130_Y1.4990.99
14_G17_T1.4720.99
69_F102_E1.4700.99
65_N95_Q1.4700.99
103_V107_L1.4470.99
7_Y112_L1.4470.99
42_D46_A1.4410.99
72_I103_V1.4370.99
117_R140_E1.4250.99
44_F50_S1.4250.99
89_C96_Q1.4250.99
126_I129_Q1.4050.99
100_L113_C1.3980.99
101_S134_W1.3840.99
34_V81_I1.3700.99
22_S112_L1.3660.99
5_Y110_P1.3300.99
155_L163_P1.3170.98
66_S71_E1.3050.98
95_Q99_E1.2890.98
122_G186_Y1.2870.98
7_Y22_S1.2870.98
70_D73_R1.2870.98
44_F52_R1.2670.98
47_G58_P1.2570.98
184_K188_E1.2360.98
32_R80_A1.2240.97
94_R123_E1.2160.97
67_S99_E1.2060.97
83_C112_L1.2020.97
37_T41_D1.2010.97
123_E130_Y1.1990.97
101_S187_K1.1880.97
37_T47_G1.1850.97
146_F179_V1.1830.97
98_Y134_W1.1780.97
32_R79_Q1.1470.96
20_L57_S1.1440.96
34_V60_K1.1400.96
23_S57_S1.1270.96
36_Y60_K1.1110.95
143_T151_A1.1060.95
13_A142_K1.1000.95
86_V92_L1.0970.95
32_R82_H1.0900.95
146_F181_V1.0730.95
104_V183_R1.0690.94
89_C131_L1.0640.94
81_I109_I1.0600.94
69_F99_E1.0460.94
122_G153_M1.0450.94
52_R174_G1.0340.93
120_F156_R1.0330.93
146_F189_A1.0180.93
25_N28_E1.0000.92
155_L189_A0.9930.92
117_R132_L0.9920.92
64_Q67_S0.9860.92
50_S56_S0.9810.91
32_R81_I0.9800.91
157_L177_R0.9770.91
126_I169_Q0.9760.91
21_Q25_N0.9710.91
174_G177_R0.9590.90
168_E171_V0.9590.90
10_A154_V0.9520.90
6_F135_S0.9520.90
136_D183_R0.9490.90
89_C115_G0.9480.90
35_V57_S0.9400.90
26_Y31_M0.9320.89
25_N144_I0.9300.89
7_Y18_A0.9260.89
20_L53_I0.9150.88
5_Y22_S0.9140.88
18_A141_L0.9120.88
99_E103_V0.9100.88
96_Q99_E0.9060.88
16_S52_R0.8980.87
29_R144_I0.8960.87
156_R171_V0.8900.87
34_V71_E0.8850.87
26_Y83_C0.8800.86
63_N66_S0.8780.86
16_S59_A0.8650.85
23_S27_Q0.8640.85
63_N70_D0.8640.85
119_D123_E0.8530.84
26_Y110_P0.8510.84
63_N67_S0.8510.84
14_G18_A0.8460.84
145_C182_C0.8460.84
73_R107_L0.8450.84
72_I109_I0.8430.84
130_Y134_W0.8420.84
130_Y133_A0.8400.84
165_N189_A0.8350.83
31_M110_P0.8260.83
122_G133_A0.8260.83
124_L129_Q0.8200.82
113_C128_S0.8200.82
10_A143_T0.8170.82
118_T133_A0.8080.81
113_C131_L0.8020.81
18_A22_S0.7990.80
142_K150_K0.7990.80
64_Q93_T0.7960.80
22_S85_L0.7810.79
134_W187_K0.7800.79
136_D152_S0.7750.78
121_R167_G0.7730.78
49_V157_L0.7710.78
45_G50_S0.7710.78
10_A142_K0.7670.78
42_D172_I0.7610.77
120_F169_Q0.7590.77
13_A28_E0.7560.77
11_M15_K0.7550.76
101_S104_V0.7470.76
83_C110_P0.7450.76
17_T51_S0.7410.75
156_R169_Q0.7240.73
165_N188_E0.7240.73
65_N99_E0.7220.73
11_M14_G0.7200.73
157_L179_V0.7190.73
4_L127_G0.7160.73
84_V111_V0.7160.73
26_Y33_T0.7150.73
100_L127_G0.7150.73
40_I170_V0.7140.72
25_N143_T0.7050.71
63_N73_R0.6990.71
25_N29_R0.6970.71
12_N28_E0.6960.70
37_T44_F0.6960.70
84_V109_I0.6960.70
60_K71_E0.6880.70
139_V142_K0.6770.68
90_Q170_V0.6770.68
141_L152_S0.6740.68
137_K142_K0.6710.68
143_T180_S0.6700.68
90_Q172_I0.6670.67
83_C109_I0.6670.67
142_K152_S0.6660.67
106_Q187_K0.6640.67
10_A118_T0.6600.66
98_Y104_V0.6580.66
163_P168_E0.6570.66
66_S175_N0.6560.66
123_E165_N0.6540.66
104_V136_D0.6530.66
97_V131_L0.6520.65
108_D184_K0.6500.65
68_L71_E0.6480.65
112_L151_A0.6410.64
12_N16_S0.6400.64
16_S174_G0.6400.64
151_A180_S0.6390.64
10_A16_S0.6350.63
28_E180_S0.6340.63
26_Y144_I0.6320.63
173_G183_R0.6280.63
111_V144_I0.6280.63
94_R129_Q0.6280.63
163_P181_V0.6270.62
27_Q32_R0.6250.62
85_L112_L0.6240.62
56_S149_R0.6230.62
126_I130_Y0.6210.62
20_L114_Y0.6210.62
110_P150_K0.6200.62
7_Y141_L0.6190.61
38_A170_V0.6180.61
89_C128_S0.6170.61
51_S150_K0.6150.61
118_T154_V0.6110.60
120_F186_Y0.6090.60
34_V72_I0.6080.60
37_T59_A0.6070.60
79_Q82_H0.6000.59
98_Y101_S0.5960.59
168_E188_E0.5950.58
8_Y132_L0.5930.58
9_S143_T0.5910.58
46_A61_L0.5900.58
5_Y140_E0.5900.58
44_F48_K0.5890.58
80_A94_R0.5860.57
8_Y180_S0.5850.57
118_T142_K0.5830.57
158_D171_V0.5820.57
67_S73_R0.5810.57
27_Q33_T0.5730.56
181_V186_Y0.5700.55
12_N180_S0.5680.55
22_S139_V0.5650.55
17_T52_R0.5640.54
99_E104_V0.5640.54
171_V176_E0.5630.54
19_L114_Y0.5600.54
12_N52_R0.5530.53
9_S62_F0.5510.53
173_G176_E0.5510.53
97_V127_G0.5500.53
36_Y68_L0.5470.52
98_Y187_K0.5470.52
13_A31_M0.5460.52
160_A164_Y0.5450.52
16_S35_V0.5450.52
39_E42_D0.5430.52
12_N19_L0.5300.50
13_A118_T0.5290.50
37_T50_S0.5260.50
28_E175_N0.5200.49
5_Y51_S0.5190.49
149_R184_K0.5190.49
143_T186_Y0.5180.48
158_D177_R0.5180.48
14_G19_L0.5170.48
17_T53_I0.5150.48
6_F128_S0.5150.48
108_D111_V0.5140.48
42_D45_G0.5130.48
27_Q107_L0.5120.48
166_E171_V0.5090.47
7_Y21_Q0.5090.47
20_L51_S0.5050.47
12_N175_N0.5050.47
96_Q127_G0.5040.47
23_S35_V0.5010.46
152_S170_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w4rA 3 0.8439 100 0.202 Contact Map
2orvA 3 0.7902 100 0.261 Contact Map
2j9rA 3 0.8195 100 0.414 Contact Map
3e2iA 3 0.8439 100 0.424 Contact Map
2b8tA 3 0.9659 100 0.444 Contact Map
1xx6A 4 0.8341 100 0.483 Contact Map
2orwA 3 0.8439 100 0.584 Contact Map
4uxhA 3 0.839 99.9 0.614 Contact Map
3e1sA 1 0.9415 98.4 0.855 Contact Map
1w36D 1 0.9268 98.2 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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