GREMLIN Database
MALY - Protein MalY
UniProt: P23256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10564
Length: 390 (347)
Sequences: 43595 (30070)
Seq/√Len: 1614.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_N55_M3.0491.00
93_G99_M3.0461.00
155_E193_R3.0321.00
346_E384_N3.0141.00
113_G134_T2.8731.00
296_K300_T2.7761.00
181_C185_E2.7471.00
301_Y376_E2.7281.00
112_E164_K2.7281.00
314_N327_D2.6861.00
72_A282_Q2.6321.00
377_K381_G2.6171.00
341_A345_Q2.6111.00
297_D372_R2.5321.00
44_P48_E2.4181.00
108_S133_R2.4111.00
68_E278_I2.3091.00
78_S84_A2.2951.00
247_I253_R2.2631.00
101_S105_R2.2111.00
305_K379_V2.1851.00
242_G277_H2.1291.00
377_K380_A2.1011.00
180_T183_E2.0901.00
185_E189_D2.0671.00
334_D337_A2.0351.00
48_E52_Q2.0181.00
141_E183_E1.9561.00
152_G186_I1.9431.00
128_I133_R1.9181.00
71_A75_H1.8961.00
195_G224_D1.8821.00
33_F378_G1.8771.00
305_K308_A1.8721.00
75_H282_Q1.8461.00
304_D308_A1.8241.00
155_E186_I1.8061.00
113_G136_M1.8041.00
153_K157_V1.8041.00
103_L226_A1.7881.00
191_C198_V1.7861.00
71_A87_S1.7761.00
303_A307_N1.7751.00
148_F183_E1.7741.00
192_E223_G1.7501.00
307_N315_W1.7411.00
165_I199_I1.7331.00
300_T304_D1.7251.00
74_A87_S1.7041.00
305_K380_A1.6951.00
301_Y305_K1.6851.00
203_I230_S1.6841.00
199_I228_L1.6811.00
150_D153_K1.6741.00
103_L199_I1.6651.00
305_K383_I1.6591.00
303_A317_I1.6501.00
113_G163_C1.6311.00
113_G159_A1.6281.00
96_V228_L1.6231.00
67_D71_A1.6081.00
118_T137_P1.6051.00
52_Q279_A1.5891.00
186_I189_D1.5721.00
153_K156_A1.5641.00
341_A385_A1.5631.00
113_G162_E1.5541.00
114_V128_I1.5521.00
302_I324_A1.5511.00
335_D354_Y1.5281.00
371_P374_K1.5141.00
72_A75_H1.5121.00
350_I364_V1.5041.00
85_I246_I1.4951.00
104_I128_I1.4891.00
68_E282_Q1.4871.00
125_Y129_E1.4831.00
47_I51_N1.4811.00
77_F246_I1.4611.00
73_I244_Y1.4551.00
189_D193_R1.4551.00
340_K344_E1.4511.00
301_Y372_R1.4371.00
182_D185_E1.4341.00
155_E194_H1.4181.00
191_C196_V1.4101.00
89_T249_N1.4081.00
337_A341_A1.3961.00
308_A383_I1.3941.00
325_W353_G1.3901.00
302_I379_V1.3881.00
226_A247_I1.3781.00
346_E381_G1.3781.00
245_G256_Y1.3751.00
118_T139_A1.3671.00
231_G277_H1.3641.00
289_D293_I1.3631.00
151_M190_L1.3631.00
303_A324_A1.3611.00
270_S273_A1.3571.00
158_L190_L1.3511.00
88_Q249_N1.3391.00
380_A384_N1.3321.00
307_N317_I1.3211.00
151_M186_I1.3161.00
73_I92_Y1.3131.00
139_A153_K1.3101.00
303_A315_W1.3081.00
72_A278_I1.3071.00
190_L194_H1.3061.00
376_E380_A1.3051.00
50_L54_L1.3031.00
181_C215_I1.3011.00
159_A163_C1.3001.00
294_Y297_D1.2881.00
337_A340_K1.2861.00
104_I167_L1.2831.00
91_V253_R1.2741.00
334_D361_R1.2411.00
115_V163_C1.2411.00
47_I55_M1.2401.00
50_L276_A1.2381.00
289_D292_R1.2331.00
293_I296_K1.2291.00
49_A279_A1.2281.00
190_L196_V1.2261.00
326_L366_L1.2221.00
183_E186_I1.2221.00
48_E51_N1.2181.00
141_E150_D1.2151.00
189_D192_E1.2091.00
116_I135_V1.2041.00
305_K376_E1.2031.00
75_H79_T1.1991.00
73_I90_V1.1931.00
299_L303_A1.1881.00
104_I108_S1.1861.00
125_Y137_P1.1851.00
294_Y372_R1.1851.00
65_K70_L1.1711.00
77_F244_Y1.1691.00
327_D363_F1.1661.00
229_T244_Y1.1651.00
68_E275_T1.1611.00
28_A347_K1.1611.00
115_V138_V1.1601.00
94_P98_Y1.1531.00
216_P219_N1.1471.00
339_Q350_I1.1431.00
155_E159_A1.1301.00
70_L74_A1.1261.00
294_Y298_N1.1181.00
105_R131_N1.1171.00
327_D362_G1.1151.00
278_I282_Q1.1141.00
181_C220_V1.1121.00
366_L378_G1.1121.00
166_M196_V1.1101.00
293_I297_D1.1101.00
79_T285_A1.1081.00
52_Q56_H1.1061.00
108_S114_V1.1021.00
210_G319_Q1.1021.00
226_A245_G1.0941.00
182_D186_I1.0931.00
86_D89_T1.0861.00
342_L382_L1.0851.00
335_D362_G1.0821.00
67_D87_S1.0791.00
372_R376_E1.0781.00
279_A282_Q1.0781.00
44_P47_I1.0771.00
128_I135_V1.0741.00
45_C283_Q1.0731.00
107_W165_I1.0731.00
155_E190_L1.0721.00
329_R362_G1.0661.00
110_T132_Q1.0651.00
198_V217_W1.0631.00
68_E71_A1.0521.00
98_Y261_K1.0501.00
74_A86_D1.0431.00
188_A225_W1.0411.00
336_N354_Y1.0411.00
74_A90_V1.0381.00
298_N301_Y1.0361.00
197_R226_A1.0261.00
99_M245_G1.0231.00
188_A198_V1.0181.00
99_M228_L1.0131.00
185_E220_V1.0121.00
107_W197_R1.0091.00
67_D70_L1.0051.00
338_L364_V0.9981.00
47_I54_L0.9961.00
86_D249_N0.9961.00
69_F92_Y0.9911.00
370_C374_K0.9911.00
299_L368_A0.9901.00
120_A169_C0.9831.00
138_V157_V0.9811.00
255_A259_A0.9781.00
342_L350_I0.9701.00
181_C219_N0.9691.00
152_G156_A0.9681.00
158_L163_C0.9611.00
197_R224_D0.9571.00
89_T253_R0.9551.00
49_A52_Q0.9541.00
114_V165_I0.9541.00
124_F167_L0.9521.00
374_K377_K0.9511.00
94_P270_S0.9471.00
300_T317_I0.9471.00
109_E112_E0.9471.00
103_L256_Y0.9441.00
91_V256_Y0.9441.00
204_H323_L0.9331.00
158_L196_V0.9311.00
149_C183_E0.9301.00
106_Q256_Y0.9281.00
90_V246_I0.9241.00
258_S261_K0.9231.00
304_D307_N0.9211.00
141_E153_K0.9201.00
29_D347_K0.9111.00
218_S227_L0.9071.00
279_A283_Q0.9061.00
228_L245_G0.9051.00
129_E135_V0.9041.00
301_Y304_D0.9001.00
302_I375_L0.8941.00
217_W225_W0.8931.00
341_A346_E0.8921.00
76_W206_D0.8901.00
290_A293_I0.8871.00
208_V211_E0.8851.00
304_D376_E0.8841.00
97_I123_A0.8831.00
302_I305_K0.8801.00
208_V214_H0.8791.00
340_K345_Q0.8791.00
181_C213_P0.8721.00
38_M295_L0.8701.00
83_T218_S0.8691.00
159_A194_H0.8661.00
33_F375_L0.8641.00
49_A53_R0.8581.00
96_V203_I0.8581.00
348_V382_L0.8581.00
202_E227_L0.8551.00
151_M187_M0.8541.00
313_L328_L0.8541.00
96_V230_S0.8491.00
197_R252_S0.8481.00
301_Y379_V0.8451.00
108_S165_I0.8451.00
299_L318_P0.8411.00
313_L326_L0.8401.00
29_D377_K0.8391.00
40_F294_Y0.8381.00
151_M183_E0.8351.00
52_Q55_M0.8341.00
336_N340_K0.8331.00
152_G155_E0.8331.00
76_W235_F0.8321.00
163_C196_V0.8251.00
97_I121_Y0.8221.00
115_V166_M0.8181.00
290_A294_Y0.8181.00
275_T278_I0.8141.00
217_W220_V0.8131.00
69_F73_I0.8111.00
192_E224_D0.8101.00
350_I366_L0.8071.00
104_I165_I0.8071.00
95_S241_T0.8071.00
286_P290_A0.8071.00
93_G245_G0.8051.00
314_N329_R0.8041.00
45_C48_E0.8031.00
115_V157_V0.8031.00
98_Y266_L0.8021.00
154_L166_M0.7961.00
66_N70_L0.7951.00
114_V133_R0.7941.00
209_W296_K0.7921.00
215_I219_N0.7901.00
348_V381_G0.7881.00
48_E55_M0.7881.00
242_G269_P0.7831.00
297_D300_T0.7801.00
206_D234_S0.7771.00
242_G273_A0.7751.00
117_H138_V0.7721.00
76_W81_H0.7711.00
106_Q260_L0.7701.00
328_L364_V0.7671.00
45_C279_A0.7641.00
338_L385_A0.7591.00
32_P37_D0.7521.00
75_H78_S0.7511.00
151_M155_E0.7511.00
117_H149_C0.7491.00
286_P289_D0.7441.00
346_E385_A0.7441.00
118_T359_E0.7431.00
336_N352_P0.7411.00
98_Y102_E0.7391.00
348_V378_G0.7381.00
66_N274_L0.7351.00
140_L172_Q0.7341.00
53_R276_A0.7321.00
373_S376_E0.7301.00
41_A47_I0.7301.00
231_G244_Y0.7271.00
115_V154_L0.7271.00
150_D183_E0.7261.00
117_H172_Q0.7261.00
285_A289_D0.7251.00
287_W291_L0.7241.00
298_N371_P0.7231.00
247_I256_Y0.7231.00
27_T347_K0.7221.00
108_S112_E0.7221.00
339_Q352_P0.7221.00
218_S221_A0.7221.00
91_V245_G0.7211.00
136_M159_A0.7141.00
226_A252_S0.7111.00
335_D352_P0.7101.00
300_T303_A0.7101.00
136_M163_C0.7091.00
254_D259_A0.7071.00
51_N54_L0.7071.00
74_A85_I0.7041.00
50_L272_L0.7031.00
302_I368_A0.7011.00
116_I128_I0.6971.00
113_G164_K0.6931.00
173_N204_H0.6931.00
58_V275_T0.6891.00
142_K314_N0.6891.00
163_C166_M0.6891.00
291_L295_L0.6871.00
287_W290_A0.6861.00
210_G299_L0.6851.00
311_P383_I0.6841.00
118_T357_G0.6811.00
215_I220_V0.6811.00
318_P321_T0.6791.00
126_K129_E0.6781.00
172_Q175_T0.6771.00
158_L194_H0.6771.00
167_L199_I0.6761.00
70_L87_S0.6741.00
261_K266_L0.6741.00
305_K311_P0.6721.00
102_E256_Y0.6721.00
166_M191_C0.6721.00
72_A281_Y0.6711.00
142_K327_D0.6711.00
124_F128_I0.6651.00
301_Y375_L0.6641.00
36_S204_H0.6641.00
104_I133_R0.6541.00
103_L228_L0.6541.00
92_Y242_G0.6531.00
339_Q364_V0.6501.00
29_D374_K0.6501.00
234_S288_L0.6501.00
353_G363_F0.6471.00
42_T45_C0.6471.00
100_V127_A0.6461.00
154_L190_L0.6461.00
326_L363_F0.6431.00
353_G356_Y0.6431.00
136_M157_V0.6421.00
202_E216_P0.6391.00
297_D301_Y0.6381.00
192_E222_R0.6381.00
288_L292_R0.6381.00
39_D298_N0.6371.00
101_S265_G0.6371.00
111_G134_T0.6371.00
302_I366_L0.6341.00
333_I338_L0.6331.00
200_S227_L0.6321.00
92_Y274_L0.6321.00
212_Q319_Q0.6321.00
116_I125_Y0.6281.00
104_I131_N0.6231.00
148_F180_T0.6201.00
101_S131_N0.6191.00
89_T248_E0.6191.00
138_V153_K0.6181.00
97_I267_S0.6171.00
141_E148_F0.6161.00
170_S202_E0.6161.00
235_F285_A0.6161.00
27_T30_L0.6141.00
325_W363_F0.6131.00
308_A376_E0.6131.00
43_A46_I0.6111.00
209_W368_A0.6081.00
210_G296_K0.6061.00
380_A383_I0.6051.00
76_W205_M0.6051.00
81_H205_M0.6041.00
221_A224_D0.6041.00
31_L377_K0.6031.00
191_C195_G0.6031.00
49_A276_A0.6021.00
338_L342_L0.5981.00
292_R296_K0.5971.00
247_I252_S0.5961.00
113_G161_P0.5951.00
184_L217_W0.5911.00
42_T46_I0.5891.00
168_L184_L0.5891.00
45_C287_W0.5881.00
91_V247_I0.5871.00
250_S254_D0.5871.00
36_S323_L0.5861.00
271_V275_T0.5851.00
177_K319_Q0.5841.00
276_A279_A0.5831.00
179_W183_E0.5831.00
69_F277_H0.5831.00
207_M292_R0.5831.00
65_K258_S0.5811.00
381_G384_N0.5801.00
101_S127_A0.5791.00
77_F227_L0.5781.00
209_W299_L0.5781.00
45_C286_P0.5781.00
335_D339_Q0.5781.00
42_T287_W0.5761.00
56_H279_A0.5721.00
315_W324_A0.5711.00
53_R56_H0.5711.00
46_I237_I0.5691.00
170_S178_V0.5691.00
46_I280_A0.5691.00
42_T47_I0.5691.00
171_P320_S0.5691.00
112_E162_E0.5681.00
216_P227_L0.5671.00
116_I137_P0.5661.00
45_C285_A0.5661.00
232_S241_T0.5651.00
342_L385_A0.5631.00
139_A157_V0.5631.00
296_K299_L0.5601.00
103_L165_I0.5591.00
223_G250_S0.5581.00
275_T279_A0.5561.00
179_W184_L0.5561.00
335_D364_V0.5551.00
306_M326_L0.5541.00
299_L317_I0.5531.00
63_R67_D0.5511.00
108_S164_K0.5471.00
335_D361_R0.5471.00
168_L171_P0.5461.00
149_C154_L0.5451.00
159_A162_E0.5441.00
104_I127_A0.5431.00
156_A159_A0.5421.00
205_M229_T0.5421.00
231_G281_Y0.5411.00
102_E261_K0.5411.00
114_V167_L0.5391.00
85_I218_S0.5381.00
71_A74_A0.5371.00
214_H217_W0.5351.00
34_T349_A0.5331.00
94_P269_P0.5331.00
165_I197_R0.5331.00
377_K384_N0.5321.00
85_I89_T0.5321.00
314_N330_P0.5321.00
298_N372_R0.5311.00
157_V161_P0.5301.00
184_L200_S0.5301.00
327_D330_P0.5301.00
215_I218_S0.5291.00
283_Q286_P0.5291.00
139_A150_D0.5271.00
307_N314_N0.5271.00
371_P376_E0.5271.00
71_A282_Q0.5251.00
173_N365_R0.5231.00
217_W221_A0.5231.00
333_I341_A0.5221.00
274_L278_I0.5211.00
325_W365_R0.5191.00
249_N254_D0.5171.00
148_F177_K0.5141.00
78_S82_Y0.5141.00
109_E164_K0.5121.00
343_I349_A0.5111.00
166_M198_V0.5111.00
298_N374_K0.5101.00
32_P35_I0.5101.00
127_A131_N0.5091.00
30_L349_A0.5091.00
192_E221_A0.5081.00
379_V383_I0.5081.00
245_G253_R0.5081.00
159_A193_R0.5081.00
99_M243_A0.5071.00
31_L381_G0.5071.00
207_M295_L0.5051.00
305_K375_L0.5041.00
154_L187_M0.5031.00
188_A221_A0.5031.00
328_L333_I0.5021.00
68_E72_A0.5001.00
95_S243_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d2fA 2 0.9385 100 0.287 Contact Map
1c7nA 2 0.9949 100 0.288 Contact Map
3t32A 2 0.9154 100 0.296 Contact Map
3piuA 2 0.9333 100 0.297 Contact Map
3dzzA 2 0.9795 100 0.297 Contact Map
3b1dA 4 0.9821 100 0.301 Contact Map
3dydA 2 0.9359 100 0.302 Contact Map
4dq6A 2 0.9795 100 0.305 Contact Map
4my5A 2 0.9769 100 0.308 Contact Map
2x5dA 3 0.9462 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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