GREMLIN Database
MGLC - Galactoside transport system permease protein MglC
UniProt: P23200 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10594
Length: 336 (271)
Sequences: 31450 (19600)
Seq/√Len: 1190.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_C240_V3.8101.00
117_A236_A3.5051.00
117_A240_V3.0281.00
121_L236_A2.9411.00
82_V115_I2.8571.00
217_P231_L2.7861.00
86_L111_I2.6491.00
210_I234_I2.4951.00
60_A289_V2.4751.00
53_I190_A2.4691.00
226_N229_L2.4401.00
129_Y228_G2.3921.00
229_L233_M2.3081.00
200_L206_F2.2901.00
120_G239_G2.2501.00
116_G243_A2.2471.00
198_W202_N2.2411.00
199_V203_K2.2391.00
121_L232_L2.1981.00
104_P107_L2.1781.00
123_N141_T2.1741.00
125_L129_Y2.1401.00
209_N230_N2.1101.00
206_F233_M2.0871.00
267_D300_N2.0751.00
196_F200_L2.0531.00
55_I268_A1.9571.00
77_G149_N1.9291.00
113_C244_F1.9071.00
83_A112_V1.8711.00
195_A199_V1.8471.00
106_A110_L1.8431.00
116_G239_G1.7931.00
83_A247_M1.7841.00
56_A289_V1.7241.00
124_G232_L1.6991.00
213_I230_N1.6961.00
49_S297_T1.6941.00
109_I247_M1.6781.00
62_L238_S1.6711.00
85_T89_S1.6511.00
143_I146_Y1.6491.00
61_G197_V1.6261.00
212_A220_A1.6231.00
86_L90_M1.5681.00
87_L108_V1.5541.00
205_R209_N1.5391.00
49_S294_I1.5191.00
53_I293_V1.5181.00
119_I145_V1.5131.00
267_D317_K1.4891.00
64_V211_F1.4891.00
158_A161_I1.4781.00
78_L119_I1.4691.00
113_C247_M1.4661.00
103_M107_L1.4491.00
129_Y232_L1.4361.00
218_E221_K1.4351.00
217_P221_K1.4351.00
172_A175_F1.4321.00
233_M236_A1.4311.00
206_F210_I1.4301.00
141_T145_V1.4151.00
74_R146_Y1.4071.00
170_T173_Q1.3951.00
85_T152_Y1.3661.00
209_N225_V1.3631.00
55_I76_V1.3591.00
76_V249_E1.3591.00
65_T234_I1.3511.00
285_T288_G1.3461.00
194_V290_V1.3261.00
107_L110_L1.2951.00
54_I245_G1.2901.00
209_N220_A1.2811.00
275_G288_G1.2801.00
125_L232_L1.2581.00
61_G234_I1.2551.00
220_A225_V1.2541.00
112_V116_G1.2531.00
58_G241_F1.2521.00
53_I290_V1.2431.00
232_L236_A1.2381.00
72_A242_Y1.2361.00
86_L103_M1.2301.00
57_L197_V1.2251.00
213_I227_V1.2211.00
213_I220_A1.2041.00
67_G231_L1.2021.00
41_N301_Y1.1961.00
45_I298_V1.1961.00
275_G292_G1.1961.00
110_L114_A1.1891.00
157_G160_P1.1751.00
128_A228_G1.1741.00
67_G134_P1.1741.00
225_V230_N1.1641.00
82_V86_L1.1611.00
54_I248_L1.1551.00
45_I297_T1.1511.00
59_V272_C1.1491.00
108_V112_V1.1461.00
202_N211_F1.1381.00
67_G235_Y1.1301.00
114_A117_A1.1291.00
75_Q119_I1.1271.00
236_A240_V1.1261.00
193_A241_F1.1241.00
59_V268_A1.1241.00
162_S165_D1.1021.00
198_W203_K1.0981.00
164_F167_G1.0951.00
56_A271_A1.0891.00
195_A198_W1.0871.00
221_K227_V1.0791.00
74_R145_V1.0791.00
49_S293_V1.0781.00
103_M111_I1.0771.00
146_Y150_S1.0721.00
264_Y267_D1.0711.00
58_G72_A1.0611.00
230_N233_M1.0601.00
84_A88_Q1.0571.00
300_N317_K1.0571.00
142_M146_Y1.0551.00
126_I137_T1.0541.00
301_Y304_T1.0541.00
197_V237_L1.0511.00
239_G243_A1.0511.00
112_V247_M1.0491.00
118_V121_L1.0461.00
221_K228_G1.0401.00
85_T153_Y1.0371.00
233_M237_L1.0341.00
192_I196_F1.0281.00
83_A251_G1.0191.00
56_A272_C1.0191.00
64_V284_G1.0171.00
210_I230_N1.0151.00
194_V241_F1.0051.00
166_S169_S1.0051.00
86_L89_S1.0041.00
188_F192_I1.0021.00
81_V149_N0.9961.00
90_M102_T0.9931.00
165_D169_S0.9851.00
117_A243_A0.9841.00
312_W315_I0.9761.00
81_V258_N0.9731.00
314_Y317_K0.9711.00
43_S47_T0.9701.00
271_A293_V0.9691.00
128_A138_T0.9691.00
237_L241_F0.9681.00
81_V153_Y0.9661.00
123_N137_T0.9631.00
55_I245_G0.9611.00
60_A272_C0.9601.00
110_L113_C0.9601.00
246_G250_A0.9551.00
125_L130_L0.9511.00
271_A292_G0.9491.00
152_Y155_F0.9451.00
114_A118_V0.9431.00
164_F168_F0.9431.00
302_G306_I0.9351.00
63_I272_C0.9351.00
185_Y188_F0.9351.00
148_I152_Y0.9271.00
74_R142_M0.9271.00
78_L82_V0.9251.00
40_L43_S0.9231.00
229_L232_L0.9221.00
287_I291_T0.9221.00
159_S162_S0.9211.00
103_M106_A0.9211.00
198_W287_I0.9201.00
206_F230_N0.9151.00
190_A194_V0.9141.00
79_A116_G0.9121.00
157_G161_I0.9081.00
50_S187_T0.9061.00
86_L108_V0.9051.00
238_S242_Y0.9051.00
65_T210_I0.9051.00
53_I194_V0.9031.00
161_I164_F0.8991.00
126_I130_L0.8931.00
263_M267_D0.8931.00
60_A284_G0.8911.00
127_I137_T0.8881.00
64_V202_N0.8841.00
219_A223_S0.8791.00
76_V264_Y0.8781.00
42_L302_G0.8731.00
191_L195_A0.8731.00
48_Q52_R0.8711.00
83_A87_L0.8681.00
80_A250_A0.8671.00
79_A112_V0.8651.00
59_V72_A0.8651.00
259_N262_F0.8641.00
151_L312_W0.8621.00
131_N217_P0.8621.00
75_Q242_Y0.8581.00
208_K211_F0.8581.00
56_A293_V0.8571.00
82_V85_T0.8541.00
73_G265_E0.8541.00
228_G231_L0.8531.00
102_T106_A0.8511.00
213_I234_I0.8451.00
51_V245_G0.8441.00
187_T191_L0.8431.00
170_T175_F0.8411.00
158_A162_S0.8411.00
54_I190_A0.8401.00
181_F188_F0.8391.00
216_N219_A0.8391.00
201_W210_I0.8371.00
186_I248_L0.8331.00
323_F327_L0.8321.00
57_L193_A0.8281.00
179_G182_R0.8251.00
76_V261_G0.8231.00
227_V231_L0.8211.00
296_F317_K0.8211.00
147_G150_S0.8201.00
283_V287_I0.8181.00
163_G166_S0.8141.00
69_D72_A0.8131.00
62_L69_D0.8091.00
107_L111_I0.8091.00
122_I126_I0.8071.00
303_L316_I0.8021.00
79_A246_G0.8021.00
80_A256_A0.7981.00
160_P163_G0.7961.00
289_V293_V0.7961.00
242_Y246_G0.7941.00
121_L125_L0.7921.00
61_G201_W0.7911.00
213_I231_L0.7901.00
73_G263_M0.7881.00
113_C243_A0.7881.00
61_G237_L0.7871.00
301_Y305_Y0.7771.00
75_Q116_G0.7761.00
57_L289_V0.7721.00
167_G170_T0.7691.00
55_I72_A0.7641.00
118_V122_I0.7631.00
157_G162_S0.7611.00
240_V243_A0.7591.00
44_N48_Q0.7491.00
285_T289_V0.7491.00
194_V198_W0.7481.00
84_A256_A0.7481.00
217_P227_V0.7471.00
58_G242_Y0.7451.00
83_A108_V0.7421.00
90_M103_M0.7411.00
185_Y189_Y0.7411.00
183_L188_F0.7411.00
228_G232_L0.7361.00
124_G129_Y0.7301.00
240_V244_F0.7261.00
170_T174_G0.7131.00
80_A260_L0.7131.00
319_A323_F0.7121.00
113_C117_A0.7031.00
62_L235_Y0.7021.00
55_I58_G0.6991.00
134_P235_Y0.6991.00
270_A321_I0.6981.00
70_L269_I0.6981.00
54_I193_A0.6981.00
79_A115_I0.6981.00
49_S53_I0.6981.00
200_L203_K0.6941.00
67_G217_P0.6901.00
76_V245_G0.6891.00
144_I148_I0.6891.00
199_V202_N0.6881.00
209_N226_N0.6851.00
52_R267_D0.6801.00
196_F199_V0.6781.00
293_V297_T0.6691.00
294_I298_V0.6661.00
176_V181_F0.6641.00
109_I113_C0.6611.00
124_G128_A0.6601.00
78_L145_V0.6581.00
75_Q123_N0.6571.00
78_L116_G0.6541.00
87_L251_G0.6511.00
46_L50_S0.6471.00
75_Q79_A0.6431.00
116_G120_G0.6411.00
120_G236_A0.6401.00
65_T213_I0.6371.00
311_Y314_Y0.6361.00
75_Q145_V0.6361.00
300_N313_Q0.6361.00
39_L42_L0.6341.00
128_A232_L0.6331.00
237_L240_V0.6291.00
227_V230_N0.6261.00
60_A286_V0.6251.00
75_Q239_G0.6241.00
58_G62_L0.6241.00
45_I301_Y0.6211.00
63_I269_I0.6201.00
206_F237_L0.6181.00
249_E264_Y0.6151.00
52_R293_V0.6141.00
50_S190_A0.6131.00
200_L233_M0.6101.00
165_D168_F0.6101.00
52_R271_A0.6101.00
155_F158_A0.6091.00
60_A64_V0.6081.00
41_N305_Y0.6081.00
149_N153_Y0.6081.00
317_K321_I0.6061.00
47_T252_R0.6041.00
169_S173_Q0.6041.00
47_T187_T0.6001.00
131_N228_G0.5981.00
51_V252_R0.5981.00
197_V201_W0.5961.00
243_A247_M0.5951.00
79_A242_Y0.5941.00
65_T231_L0.5931.00
274_V292_G0.5931.00
275_G289_V0.5911.00
146_Y262_F0.5891.00
257_T260_L0.5891.00
45_I49_S0.5891.00
82_V111_I0.5861.00
113_C116_G0.5851.00
52_R264_Y0.5841.00
44_N301_Y0.5841.00
127_I235_Y0.5821.00
310_P313_Q0.5821.00
267_D314_Y0.5811.00
77_G261_G0.5801.00
61_G200_L0.5791.00
197_V241_F0.5791.00
193_A244_F0.5781.00
231_L234_I0.5771.00
249_E253_I0.5751.00
149_N152_Y0.5731.00
103_M108_V0.5701.00
158_A163_G0.5691.00
86_L115_I0.5691.00
51_V249_E0.5681.00
146_Y265_E0.5681.00
127_I134_P0.5681.00
75_Q120_G0.5671.00
192_I195_A0.5621.00
46_L49_S0.5611.00
174_G185_Y0.5611.00
202_N205_R0.5591.00
200_L204_T0.5541.00
218_E222_V0.5541.00
143_I147_G0.5531.00
82_V116_G0.5521.00
85_T88_Q0.5511.00
239_G242_Y0.5501.00
288_G292_G0.5501.00
220_A227_V0.5491.00
139_L143_I0.5491.00
57_L194_V0.5481.00
142_M265_E0.5431.00
53_I57_L0.5411.00
72_A238_S0.5391.00
71_S123_N0.5381.00
236_A239_G0.5381.00
83_A246_G0.5381.00
48_Q301_Y0.5361.00
272_C289_V0.5361.00
39_L43_S0.5341.00
104_P108_V0.5321.00
271_A289_V0.5311.00
262_F265_E0.5281.00
303_L308_V0.5261.00
175_F182_R0.5251.00
57_L195_A0.5241.00
52_R56_A0.5231.00
274_V324_A0.5231.00
198_W285_T0.5231.00
158_A164_F0.5211.00
62_L67_G0.5201.00
117_A120_G0.5171.00
268_A272_C0.5161.00
271_A296_F0.5151.00
82_V112_V0.5121.00
105_I251_G0.5111.00
78_L115_I0.5101.00
167_G180_S0.5071.00
57_L198_W0.5061.00
166_S170_T0.5021.00
211_F214_G0.5021.00
189_Y193_A0.5021.00
117_A239_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8244 97.4 0.87 Contact Map
4g1uA 2 0.8006 96.9 0.881 Contact Map
2qi9A 2 0.869 96.7 0.884 Contact Map
1u7gA 3 0.5655 28.4 0.947 Contact Map
3p5nA 2 0.2946 10.8 0.956 Contact Map
2onkC 2 0.7143 9.7 0.957 Contact Map
2jwaA 2 0.131 9 0.958 Contact Map
2gfpA 2 0.5268 9 0.958 Contact Map
2b2hA 3 0.628 8.8 0.958 Contact Map
2ks1B 1 0.128 7.4 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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