GREMLIN Database
TNAB - Low affinity tryptophan permease
UniProt: P23173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11006
Length: 415 (381)
Sequences: 29736 (19806)
Seq/√Len: 1014.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
324_F327_V4.4081.00
318_N321_G3.6001.00
50_W238_L3.3541.00
324_F328_L3.0931.00
221_K224_D3.0641.00
10_S220_G3.0071.00
392_V396_G2.7591.00
224_D228_K2.7541.00
15_V232_F2.6741.00
219_Y225_K2.6621.00
78_K86_N2.6491.00
11_A232_F2.5211.00
282_I286_C2.4871.00
370_K374_K2.4361.00
325_K328_L2.3511.00
361_V367_L2.3471.00
218_C308_D2.3081.00
272_K275_L2.2951.00
367_L371_A2.2871.00
318_N322_G2.2791.00
90_G313_L2.2741.00
14_G219_Y2.2561.00
228_K232_F2.2551.00
266_N269_S2.2331.00
11_A15_V2.2291.00
138_A332_L2.1781.00
368_A372_R2.1571.00
10_S13_W2.1541.00
221_K225_K2.1451.00
168_G172_F2.1441.00
15_V236_L2.1001.00
323_R327_V2.0621.00
170_F247_C2.0531.00
370_K373_K2.0481.00
217_I315_K2.0431.00
390_A394_L2.0431.00
78_K83_N2.0391.00
11_A225_K2.0111.00
139_S143_L1.9941.00
157_G161_I1.9781.00
311_A315_K1.8711.00
386_N390_A1.8611.00
316_I319_S1.8581.00
324_F331_F1.8471.00
18_I233_G1.8421.00
146_L150_R1.8311.00
398_T402_C1.8111.00
77_T89_S1.8081.00
225_K228_K1.8031.00
231_V235_L1.7971.00
317_D320_H1.7941.00
253_P256_S1.7701.00
361_V365_A1.7431.00
81_I85_W1.7421.00
359_W363_I1.7391.00
380_F383_W1.7281.00
387_L391_I1.6871.00
51_F55_H1.6861.00
319_S322_G1.6851.00
82_G85_W1.6691.00
318_N325_K1.6621.00
235_L239_V1.6581.00
9_H13_W1.6571.00
363_I367_L1.6481.00
394_L398_T1.5871.00
373_K376_P1.5781.00
19_A236_L1.5741.00
161_I165_I1.5711.00
328_L331_F1.5711.00
323_R328_L1.5461.00
392_V395_F1.5451.00
13_W149_S1.5381.00
131_I135_I1.5281.00
389_P392_V1.5281.00
13_W153_S1.5241.00
272_K276_G1.5041.00
339_L342_P1.4891.00
385_G389_P1.4871.00
141_L300_F1.4861.00
356_A359_W1.4821.00
323_R326_T1.4711.00
359_W367_L1.4621.00
22_V237_A1.4371.00
49_A202_C1.4361.00
324_F335_A1.4321.00
356_A361_V1.4251.00
325_K329_L1.4211.00
175_D179_L1.4171.00
67_Y79_D1.4101.00
384_G388_I1.4081.00
388_I392_V1.4001.00
108_N133_T1.3941.00
317_D321_G1.3851.00
58_L231_V1.3821.00
125_N128_I1.3781.00
285_F289_V1.3771.00
335_A339_L1.3761.00
324_F342_P1.3741.00
389_P393_I1.3731.00
124_A128_I1.3701.00
174_V250_G1.3621.00
45_I198_A1.3611.00
338_Y342_P1.3601.00
266_N272_K1.3571.00
327_V331_F1.3571.00
108_N292_N1.3421.00
54_L231_V1.3401.00
14_G229_S1.3391.00
11_A228_K1.3351.00
356_A363_I1.3291.00
345_F349_I1.3281.00
112_I129_V1.3271.00
372_R376_P1.3191.00
51_F391_I1.3101.00
238_L242_L1.3081.00
105_I299_F1.3081.00
166_V170_F1.2871.00
167_F243_F1.2801.00
335_A338_Y1.2781.00
81_I370_K1.2741.00
390_A393_I1.2711.00
57_G230_V1.2651.00
171_F247_C1.2611.00
70_G217_I1.2611.00
317_D322_G1.2551.00
387_L390_A1.2551.00
397_I401_L1.2541.00
270_L275_L1.2541.00
34_L42_G1.2491.00
329_L333_P1.2381.00
131_I339_L1.2341.00
104_Y298_S1.2301.00
365_A368_A1.2291.00
361_V364_P1.2291.00
358_I363_I1.2291.00
9_H14_G1.2181.00
215_L304_L1.2171.00
127_R131_I1.2161.00
69_V79_D1.2101.00
356_A367_L1.2091.00
362_I393_I1.2071.00
160_I164_V1.2071.00
43_A246_Y1.1991.00
269_S272_K1.1911.00
366_V370_K1.1901.00
391_I395_F1.1811.00
162_S290_F1.1801.00
321_G325_K1.1791.00
268_D272_K1.1781.00
155_F297_S1.1771.00
12_F16_M1.1751.00
239_V243_F1.1721.00
87_I91_I1.1691.00
360_A364_P1.1661.00
127_R130_G1.1591.00
222_R227_I1.1511.00
338_Y341_F1.1461.00
270_L273_S1.1401.00
336_L340_I1.1391.00
41_W195_I1.1381.00
188_G191_Y1.1381.00
358_I361_V1.1341.00
57_G234_S1.1201.00
316_I326_T1.1181.00
358_I365_A1.1171.00
60_L73_F1.1171.00
398_T401_L1.1171.00
324_F329_L1.1061.00
256_S276_G1.1051.00
75_T79_D1.1021.00
361_V368_A1.0991.00
318_N323_R1.0991.00
356_A360_A1.0981.00
382_V385_G1.0961.00
128_I132_C1.0951.00
345_F352_A1.0921.00
170_F251_N1.0911.00
328_L332_L1.0881.00
69_V75_T1.0851.00
371_A374_K1.0741.00
359_W366_V1.0741.00
77_T85_W1.0711.00
84_T88_I1.0701.00
396_G399_V1.0651.00
105_I134_A1.0631.00
400_I404_F1.0561.00
324_F341_F1.0531.00
395_F398_T1.0521.00
192_F196_F1.0501.00
395_F399_V1.0481.00
64_N76_I1.0461.00
378_Q381_T1.0431.00
191_Y194_Y1.0411.00
367_L370_K1.0361.00
324_F338_Y1.0351.00
389_P396_G1.0341.00
326_T329_L1.0321.00
178_I182_A1.0321.00
265_G269_S1.0221.00
164_V168_G1.0191.00
254_R257_F1.0181.00
192_F195_I1.0171.00
325_K330_T1.0161.00
129_V132_C1.0131.00
281_G285_F1.0101.00
171_F175_D1.0051.00
138_A328_L1.0011.00
319_S323_R1.0001.00
327_V335_A1.0001.00
172_F175_D1.0001.00
54_L58_L0.9971.00
359_W362_I0.9971.00
385_G388_I0.9961.00
8_K220_G0.9941.00
128_I131_I0.9901.00
180_R183_T0.9841.00
172_F176_Y0.9801.00
221_K228_K0.9771.00
325_K335_A0.9681.00
18_I212_I0.9661.00
33_D42_G0.9651.00
23_I26_G0.9601.00
11_A229_S0.9571.00
355_C358_I0.9561.00
336_L339_L0.9551.00
142_W325_K0.9531.00
52_S395_F0.9511.00
165_I169_S0.9491.00
386_N389_P0.9481.00
327_V330_T0.9471.00
151_I155_F0.9411.00
220_G225_K0.9401.00
137_V299_F0.9401.00
392_V398_T0.9361.00
143_L321_G0.9351.00
393_I397_I0.9321.00
152_T300_F0.9321.00
325_K332_L0.9301.00
47_I242_L0.9291.00
279_Q283_I0.9281.00
326_T330_T0.9261.00
112_I116_I0.9241.00
59_L389_P0.9241.00
320_H324_F0.9231.00
50_W206_F0.9231.00
175_D178_I0.9211.00
94_A310_L0.9171.00
186_T189_T0.9151.00
16_M153_S0.9141.00
113_S117_S0.9121.00
150_R154_L0.9101.00
367_L374_K0.9101.00
321_G324_F0.9091.00
55_H59_L0.9071.00
15_V229_S0.9051.00
359_W365_A0.9051.00
358_I367_L0.9031.00
174_V177_S0.9011.00
62_E65_L0.8961.00
179_L183_T0.8951.00
196_F398_T0.8891.00
327_V338_Y0.8871.00
364_P367_L0.8871.00
379_M383_W0.8861.00
135_I332_L0.8811.00
325_K331_F0.8811.00
140_V151_I0.8781.00
132_C136_F0.8761.00
389_P395_F0.8761.00
346_I349_I0.8761.00
159_K294_A0.8711.00
32_V35_A0.8701.00
93_V97_L0.8621.00
56_S209_H0.8601.00
325_K336_L0.8571.00
177_S180_R0.8561.00
363_I366_V0.8551.00
365_A392_V0.8471.00
329_L332_L0.8431.00
62_E372_R0.8391.00
176_Y179_L0.8381.00
399_V402_C0.8371.00
361_V371_A0.8351.00
282_I285_F0.8351.00
98_Y102_Y0.8331.00
364_P371_A0.8331.00
9_H149_S0.8311.00
364_P368_A0.8291.00
107_A111_I0.8291.00
167_F171_F0.8281.00
371_A375_F0.8261.00
361_V370_K0.8211.00
269_S273_S0.8201.00
153_S157_G0.8181.00
150_R153_S0.8181.00
147_A150_R0.8161.00
55_H391_I0.8091.00
320_H323_R0.8031.00
43_A249_M0.8021.00
345_F353_G0.8021.00
63_A76_I0.8001.00
17_V215_L0.7961.00
331_F334_P0.7941.00
265_G268_D0.7911.00
359_W364_P0.7891.00
131_I336_L0.7871.00
280_H283_I0.7861.00
366_V369_I0.7861.00
135_I139_S0.7801.00
399_V403_W0.7801.00
347_Y350_G0.7801.00
318_N324_F0.7791.00
358_I362_I0.7791.00
355_C365_A0.7791.00
114_E288_L0.7761.00
138_A142_W0.7751.00
269_S275_L0.7711.00
44_F48_I0.7701.00
324_F334_P0.7701.00
382_V386_N0.7691.00
246_Y250_G0.7691.00
145_S304_L0.7671.00
106_S110_A0.7661.00
126_P130_G0.7631.00
286_C290_F0.7561.00
366_V371_A0.7561.00
210_G214_S0.7551.00
357_T365_A0.7541.00
19_A237_A0.7531.00
335_A342_P0.7521.00
324_F332_L0.7521.00
332_L335_A0.7511.00
74_N312_D0.7491.00
179_L182_A0.7491.00
368_A371_A0.7481.00
325_K341_F0.7471.00
323_R338_Y0.7471.00
43_A47_I0.7451.00
65_L379_M0.7431.00
332_L336_L0.7421.00
322_G325_K0.7411.00
393_I396_G0.7401.00
102_Y348_G0.7381.00
401_L404_F0.7361.00
216_I226_L0.7361.00
181_D184_S0.7341.00
383_W387_L0.7331.00
113_S126_P0.7331.00
382_V389_P0.7321.00
139_S142_W0.7301.00
103_A204_A0.7281.00
395_F404_F0.7241.00
167_F247_C0.7241.00
59_L365_A0.7221.00
275_L284_E0.7221.00
221_K227_I0.7221.00
109_G129_V0.7211.00
89_S363_I0.7201.00
23_I240_I0.7151.00
179_L184_S0.7141.00
396_G400_I0.7121.00
384_G389_P0.7111.00
362_I365_A0.7091.00
30_L245_L0.7091.00
365_A369_I0.7071.00
392_V403_W0.7051.00
74_N90_G0.7021.00
57_G209_H0.6991.00
392_V399_V0.6981.00
222_R225_K0.6981.00
369_I390_A0.6971.00
380_F386_N0.6971.00
71_S75_T0.6971.00
12_F15_V0.6971.00
85_W88_I0.6951.00
381_T385_G0.6941.00
362_I366_V0.6941.00
173_Q176_Y0.6931.00
134_A335_A0.6931.00
49_A203_L0.6921.00
101_T303_T0.6911.00
175_D183_T0.6911.00
134_A138_A0.6881.00
381_T384_G0.6871.00
66_N378_Q0.6851.00
130_G339_L0.6851.00
21_T301_G0.6841.00
323_R331_F0.6831.00
363_I370_K0.6821.00
367_L372_R0.6821.00
180_R184_S0.6801.00
273_S276_G0.6771.00
14_G215_L0.6771.00
331_F335_A0.6761.00
41_W188_G0.6751.00
361_V366_V0.6741.00
81_I366_V0.6701.00
143_L147_A0.6661.00
369_I373_K0.6641.00
177_S181_D0.6601.00
337_L340_I0.6571.00
392_V404_F0.6551.00
64_N213_P0.6521.00
365_A371_A0.6511.00
331_F342_P0.6471.00
380_F384_G0.6471.00
358_I364_P0.6461.00
44_F47_I0.6451.00
382_V388_I0.6411.00
15_V18_I0.6411.00
167_F170_F0.6391.00
357_T360_A0.6381.00
109_G130_G0.6381.00
374_K377_N0.6371.00
396_G403_W0.6331.00
13_W150_R0.6311.00
42_G245_L0.6311.00
147_A151_I0.6311.00
245_L249_M0.6301.00
323_R341_F0.6281.00
219_Y226_L0.6271.00
268_D271_V0.6251.00
325_K333_P0.6241.00
333_P337_L0.6241.00
343_N346_I0.6231.00
368_A389_P0.6201.00
337_L341_F0.6201.00
194_Y197_M0.6201.00
232_F236_L0.6181.00
20_G156_L0.6181.00
105_I108_N0.6161.00
141_L304_L0.6131.00
323_R335_A0.6131.00
386_N392_V0.6121.00
62_E66_N0.6111.00
319_S325_K0.6111.00
232_F235_L0.6081.00
331_F338_Y0.6071.00
271_V274_F0.6061.00
372_R375_F0.6051.00
211_N305_G0.6051.00
343_N347_Y0.6031.00
8_K12_F0.6021.00
378_Q382_V0.6011.00
187_A191_Y0.6011.00
382_V392_V0.6011.00
384_G387_L0.6001.00
197_M201_V0.6001.00
53_M209_H0.5991.00
386_N393_I0.5971.00
149_S153_S0.5971.00
388_I395_F0.5971.00
74_N86_N0.5971.00
66_N379_M0.5951.00
360_A363_I0.5941.00
137_V300_F0.5921.00
361_V374_K0.5911.00
23_I159_K0.5911.00
47_I51_F0.5891.00
178_I181_D0.5881.00
153_S156_L0.5881.00
187_A190_S0.5881.00
381_T386_N0.5871.00
142_W329_L0.5871.00
106_S348_G0.5861.00
267_V270_L0.5861.00
355_C362_I0.5851.00
236_L240_I0.5841.00
108_N296_A0.5841.00
327_V342_P0.5821.00
174_V179_L0.5801.00
156_L159_K0.5801.00
394_L397_I0.5801.00
132_C135_I0.5781.00
371_A376_P0.5781.00
196_F200_P0.5781.00
316_I320_H0.5771.00
54_L234_S0.5761.00
346_I350_G0.5761.00
66_N376_P0.5761.00
332_L342_P0.5741.00
19_A23_I0.5681.00
93_V96_V0.5681.00
334_P338_Y0.5681.00
18_I22_V0.5671.00
104_Y107_A0.5671.00
357_T361_V0.5661.00
135_I138_A0.5661.00
27_M244_W0.5661.00
76_I213_P0.5641.00
179_L250_G0.5641.00
303_T307_F0.5631.00
400_I403_W0.5631.00
356_A365_A0.5621.00
384_G390_A0.5621.00
53_M56_S0.5611.00
115_T292_N0.5611.00
308_D311_A0.5611.00
365_A370_K0.5601.00
389_P403_W0.5571.00
109_G126_P0.5561.00
360_A367_L0.5561.00
299_F334_P0.5551.00
22_V233_G0.5541.00
247_C250_G0.5531.00
317_D323_R0.5531.00
399_V404_F0.5521.00
360_A368_A0.5501.00
367_L373_K0.5481.00
77_T86_N0.5471.00
108_N295_V0.5471.00
12_F150_R0.5451.00
332_L339_L0.5451.00
325_K342_P0.5441.00
24_G27_M0.5441.00
308_D314_F0.5441.00
265_G272_K0.5421.00
63_A80_L0.5411.00
236_L243_F0.5411.00
359_W368_A0.5401.00
281_G284_E0.5391.00
86_N90_G0.5391.00
271_V275_L0.5391.00
46_L245_L0.5371.00
269_S276_G0.5371.00
227_I230_V0.5371.00
355_C367_L0.5361.00
383_W386_N0.5361.00
306_L310_L0.5351.00
359_W371_A0.5351.00
285_F288_L0.5341.00
104_Y299_F0.5341.00
112_I292_N0.5321.00
219_Y229_S0.5301.00
135_I336_L0.5291.00
21_T302_V0.5261.00
18_I21_T0.5251.00
160_I240_I0.5241.00
140_V144_S0.5241.00
83_N87_I0.5231.00
108_N112_I0.5231.00
133_T137_V0.5231.00
94_A331_F0.5231.00
8_K146_L0.5171.00
25_G29_A0.5161.00
362_I397_I0.5151.00
379_M382_V0.5141.00
17_V20_G0.5131.00
39_F249_M0.5111.00
101_T105_I0.5111.00
123_H126_P0.5111.00
152_T159_K0.5111.00
81_I368_A0.5111.00
299_F302_V0.5101.00
100_L103_A0.5091.00
335_A341_F0.5091.00
138_A303_T0.5091.00
393_I402_C0.5071.00
8_K145_S0.5071.00
25_G204_A0.5071.00
327_V341_F0.5071.00
98_Y333_P0.5061.00
356_A369_I0.5051.00
12_F153_S0.5051.00
366_V393_I0.5041.00
244_W248_T0.5041.00
52_S55_H0.5041.00
105_I109_G0.5041.00
74_N78_K0.5031.00
360_A365_A0.5021.00
324_F333_P0.5011.00
388_I391_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9205 100 0.312 Contact Map
3giaA 1 0.9398 100 0.381 Contact Map
4djkA 2 0.9325 100 0.393 Contact Map
2jlnA 1 0.9325 98.9 0.806 Contact Map
3dh4A 3 0.9229 98.6 0.825 Contact Map
2xq2A 2 0.9229 98.4 0.833 Contact Map
4wgvA 2 0.8723 98.4 0.833 Contact Map
4us3A 1 0.9446 98.2 0.842 Contact Map
4xp4A 1 0.9639 98.2 0.843 Contact Map
2a65A 2 0.9783 98.2 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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