GREMLIN Database
ISPA - Farnesyl diphosphate synthase
UniProt: P22939 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10508
Length: 299 (264)
Sequences: 9707 (6620)
Seq/√Len: 407.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_G66_L3.5311.00
191_R209_D3.2771.00
200_K204_A3.1171.00
187_R209_D2.9951.00
93_D103_V2.8741.00
144_E191_R2.7621.00
170_P173_A2.7071.00
187_R213_E2.5591.00
144_E195_L2.5581.00
179_R213_E2.5551.00
120_L123_S2.5021.00
94_L99_P2.4611.00
191_R205_L2.3971.00
238_R241_A2.2651.00
231_D234_T2.2011.00
55_T208_L2.1481.00
141_M192_L2.1181.00
194_A208_L2.0721.00
140_S205_L2.0431.00
176_R180_H2.0421.00
106_G109_N2.0181.00
265_D269_D2.0161.00
89_M158_Q1.9871.00
55_T190_V1.9651.00
264_R268_D1.9171.00
262_K265_D1.8891.00
210_K214_S1.8731.00
190_V212_A1.8661.00
59_F204_A1.8441.00
126_S142_I1.8331.00
171_L254_L1.7701.00
206_P210_K1.7591.00
266_L269_D1.6891.00
109_N159_A1.6691.00
83_H115_D1.6651.00
199_D204_A1.6551.00
276_Q280_Q1.6491.00
83_H114_G1.6331.00
68_A127_D1.6251.00
188_A192_L1.6251.00
140_S202_R1.6231.00
200_K203_R1.6051.00
284_T288_E1.5911.00
167_K173_A1.5891.00
241_A245_L1.5771.00
127_D143_S1.5641.00
82_I101_C1.5301.00
254_L258_Q1.5211.00
194_A199_D1.5161.00
56_G61_V1.4991.00
160_L176_R1.4931.00
92_D241_A1.4801.00
158_Q161_D1.4671.00
37_Q41_L1.4651.00
260_R263_A1.4601.00
193_G197_A1.4511.00
140_S143_S1.4501.00
277_L280_Q1.4451.00
54_A57_H1.4421.00
232_T239_Q1.4411.00
230_G235_L1.4201.00
187_R191_R1.4141.00
15_N18_L1.4081.00
11_V14_A1.4021.00
174_L178_H1.3981.00
202_R206_P1.3921.00
258_Q261_K1.3831.00
285_S288_E1.3661.00
42_L98_L1.3611.00
11_V15_N1.3531.00
285_S289_A1.3511.00
268_D272_Q1.3431.00
232_T238_R1.3321.00
55_T59_F1.3251.00
53_Y70_A1.3231.00
80_S154_M1.3191.00
69_P141_M1.3181.00
86_L107_E1.3051.00
179_R217_L1.3041.00
75_C124_I1.2831.00
214_S269_D1.2751.00
267_I271_R1.2751.00
144_E188_A1.2731.00
72_A125_L1.2731.00
12_K15_N1.2721.00
14_A18_L1.2591.00
140_S195_L1.2551.00
141_M196_S1.2351.00
225_I229_V1.2281.00
31_P163_D1.2261.00
153_G180_H1.2221.00
31_P106_G1.2201.00
185_L189_A1.2111.00
59_F197_A1.2011.00
194_A205_L1.2001.00
176_R179_R1.1831.00
123_S149_S1.1781.00
286_A289_A1.1761.00
254_L257_E1.1721.00
160_L180_H1.1661.00
261_K265_D1.1661.00
226_L235_L1.1661.00
16_Q20_R1.1621.00
164_A169_V1.1601.00
184_A187_R1.1601.00
17_A21_F1.1591.00
43_G46_R1.1521.00
266_L271_R1.1401.00
191_R195_L1.1391.00
17_A68_A1.1371.00
39_G101_C1.1281.00
59_F193_G1.1271.00
18_L21_F1.1261.00
35_T101_C1.1201.00
171_L175_E1.1201.00
190_V208_L1.1171.00
160_L177_I1.1151.00
51_L190_V1.1051.00
56_G197_A1.0961.00
53_Y67_D1.0901.00
261_K264_R1.0891.00
69_P192_L1.0861.00
13_Q67_D1.0841.00
178_H217_L1.0821.00
266_L270_A1.0721.00
203_R207_V1.0681.00
204_A207_V1.0671.00
99_P103_V1.0661.00
86_L111_I1.0561.00
17_A20_R1.0521.00
175_E217_L1.0481.00
59_F199_D1.0441.00
102_H107_E1.0401.00
94_L232_T1.0401.00
174_L253_L1.0401.00
17_A71_A1.0341.00
164_A177_I1.0261.00
229_V260_R1.0231.00
228_V251_P1.0141.00
52_V73_V1.0121.00
189_A193_G1.0111.00
31_P34_E1.0111.00
89_M112_L1.0081.00
125_L141_M1.0031.00
69_P125_L1.0031.00
122_F146_A1.0021.00
175_E179_R1.0011.00
19_S37_Q0.9941.00
99_P104_K0.9931.00
30_T34_E0.9921.00
228_V243_Q0.9911.00
76_I145_L0.9761.00
13_Q16_Q0.9681.00
91_D107_E0.9671.00
276_Q279_E0.9651.00
62_S65_T0.9621.00
207_V211_Y0.9621.00
16_Q19_S0.9501.00
34_E38_Y0.9501.00
19_S23_A0.9491.00
169_V173_A0.9481.00
177_I247_K0.9471.00
52_V66_L0.9461.00
46_R49_P0.9371.00
150_G188_A0.9321.00
145_L192_L0.9301.00
164_A173_A0.9261.00
269_D273_S0.9261.00
166_G246_G0.9261.00
210_K213_E0.9231.00
259_A263_A0.9231.00
258_Q262_K0.9171.00
53_Y66_L0.9171.00
206_P209_D0.9131.00
10_C13_Q0.9071.00
13_Q57_H0.9001.00
280_Q284_T0.8971.00
75_C120_L0.8971.00
69_P196_S0.8901.00
33_V37_Q0.8881.00
36_M116_A0.8841.00
38_Y104_K0.8831.00
235_L239_Q0.8831.00
123_S152_A0.8821.00
222_Q263_A0.8741.00
187_R212_A0.8731.00
14_A17_A0.8711.00
20_R23_A0.8711.00
12_K16_Q0.8711.00
191_R206_P0.8691.00
38_Y105_F0.8681.00
190_V211_Y0.8671.00
165_E248_S0.8651.00
41_L98_L0.8641.00
61_V66_L0.8621.00
209_D213_E0.8601.00
171_L257_E0.8601.00
161_D247_K0.8591.00
213_E217_L0.8511.00
93_D102_H0.8501.00
205_L209_D0.8461.00
271_R288_E0.8441.00
123_S127_D0.8441.00
71_A124_I0.8431.00
195_L205_L0.8371.00
265_D268_D0.8371.00
10_C14_A0.8361.00
38_Y98_L0.8331.00
123_S143_S0.8321.00
273_S276_Q0.8311.00
126_S143_S0.8311.00
275_K288_E0.8271.00
82_I110_A0.8231.00
22_I37_Q0.8211.00
225_I256_L0.8171.00
68_A128_A0.8171.00
172_D175_E0.8151.00
101_C105_F0.8081.00
18_L46_R0.8071.00
79_Y118_Q0.8041.00
163_D167_K0.8011.00
49_P78_A0.8001.00
24_P127_D0.7991.00
277_L284_T0.7961.00
130_M140_S0.7911.00
226_L230_G0.7881.00
58_M208_L0.7871.00
144_E209_D0.7851.00
66_L196_S0.7841.00
101_C104_K0.7811.00
100_T103_V0.7811.00
278_A284_T0.7791.00
150_G153_G0.7791.00
284_T287_L0.7781.00
255_G259_A0.7771.00
207_V276_Q0.7711.00
210_K273_S0.7711.00
48_R219_F0.7701.00
13_Q63_T0.7691.00
116_A155_C0.7651.00
15_N19_S0.7591.00
219_F223_D0.7591.00
18_L25_L0.7591.00
221_V225_I0.7581.00
10_C57_H0.7551.00
51_L215_I0.7551.00
36_M117_L0.7471.00
171_L250_Y0.7451.00
227_D241_A0.7451.00
52_V70_A0.7391.00
160_L164_A0.7391.00
108_A162_L0.7361.00
67_D71_A0.7321.00
39_G78_A0.7311.00
118_Q155_C0.7301.00
179_R184_A0.7301.00
272_Q275_K0.7291.00
230_G234_T0.7291.00
251_P254_L0.7271.00
39_G82_I0.7251.00
223_D226_L0.7211.00
119_T155_C0.7201.00
68_A71_A0.7161.00
57_H63_T0.7151.00
128_A131_P0.7121.00
31_P109_N0.7071.00
69_P128_A0.7021.00
89_M155_C0.7011.00
68_A124_I0.6961.00
154_M186_I0.6931.00
98_L104_K0.6931.00
222_Q225_I0.6931.00
214_S266_L0.6901.00
274_L277_L0.6801.00
197_A200_K0.6770.99
52_V193_G0.6750.99
73_V192_L0.6700.99
35_T113_A0.6630.99
171_L253_L0.6590.99
35_T109_N0.6590.99
36_M113_A0.6580.99
52_V189_A0.6570.99
20_R68_A0.6570.99
177_I180_H0.6570.99
186_I215_I0.6560.99
10_C50_F0.6540.99
252_A271_R0.6540.99
77_H80_S0.6530.99
45_K219_F0.6530.99
235_L238_R0.6480.99
172_D176_R0.6460.99
13_Q17_A0.6450.99
80_S185_L0.6450.99
214_S217_L0.6450.99
250_Y254_L0.6440.99
28_Q176_R0.6430.99
182_T219_F0.6420.99
211_Y214_S0.6410.99
73_V189_A0.6390.99
230_G239_Q0.6380.99
82_I117_L0.6380.99
180_H184_A0.6370.99
29_N33_V0.6370.99
169_V248_S0.6330.99
183_G217_L0.6310.99
86_L108_A0.6290.99
35_T105_F0.6280.99
279_E285_S0.6250.99
30_T33_V0.6230.99
275_K280_Q0.6180.99
192_L196_S0.6140.99
202_R205_L0.6130.99
124_I127_D0.6120.99
241_A244_Q0.6110.99
207_V273_S0.6110.99
149_S153_G0.6100.99
275_K278_A0.6070.99
227_D235_L0.6070.99
89_M162_L0.6060.99
82_I113_A0.6060.99
82_I86_L0.6030.99
119_T122_F0.5990.99
56_G196_S0.5940.99
153_G156_G0.5940.99
120_L152_A0.5930.99
182_T186_I0.5930.99
207_V210_K0.5920.99
153_G179_R0.5900.99
269_D272_Q0.5900.99
174_L250_Y0.5890.99
42_L78_A0.5870.99
140_S144_E0.5860.99
232_T235_L0.5840.99
47_L186_I0.5810.98
279_E284_T0.5780.98
159_A163_D0.5770.98
156_G180_H0.5770.98
61_V193_G0.5760.98
48_R77_H0.5730.98
32_V35_T0.5720.98
175_E221_V0.5720.98
27_F33_V0.5720.98
107_E111_I0.5710.98
59_F208_L0.5680.98
91_D102_H0.5640.98
79_Y119_T0.5630.98
161_D165_E0.5610.98
53_Y57_H0.5590.98
222_Q229_V0.5590.98
271_R274_L0.5590.98
120_L124_I0.5580.98
65_T130_M0.5560.98
155_C162_L0.5560.98
35_T38_Y0.5550.98
262_K266_L0.5510.98
13_Q64_N0.5490.98
259_A262_K0.5490.98
20_R24_P0.5470.98
65_T128_A0.5440.98
276_Q284_T0.5440.98
274_L287_L0.5430.98
270_A273_S0.5430.98
256_L260_R0.5420.98
64_N67_D0.5420.98
14_A22_I0.5420.98
46_R50_F0.5400.98
75_C117_L0.5380.97
165_E245_L0.5370.97
160_L173_A0.5350.97
227_D238_R0.5340.97
270_A274_L0.5330.97
184_A213_E0.5330.97
255_G287_L0.5300.97
164_A167_K0.5290.97
76_I121_A0.5280.97
28_Q31_P0.5270.97
257_E260_R0.5260.97
223_D237_K0.5260.97
92_D238_R0.5250.97
254_L262_K0.5210.97
20_R67_D0.5160.97
18_L41_L0.5140.97
126_S146_A0.5130.97
141_M195_L0.5130.97
273_S280_Q0.5130.97
260_R264_R0.5100.97
50_F54_A0.5100.97
23_A26_P0.5100.97
21_F24_P0.5090.96
122_F125_L0.5020.96
94_L100_T0.5020.96
21_F25_L0.5010.96
199_D205_L0.5010.96
17_A67_D0.5000.96
39_G42_L0.5000.96
56_G193_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jxyA 5 0.893 100 0.119 Contact Map
1rqjA 2 0.99 100 0.122 Contact Map
3oyrA 2 0.9565 100 0.124 Contact Map
3lsnA 2 0.9264 100 0.124 Contact Map
3pdeA 2 0.9465 100 0.126 Contact Map
3ts7A 2 0.9431 100 0.126 Contact Map
1wy0A 2 0.9632 100 0.129 Contact Map
3wjkA 2 0.9331 100 0.129 Contact Map
3mzvA 2 0.9565 100 0.132 Contact Map
2h8oA 2 0.9097 100 0.133 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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