GREMLIN Database
MURI - Glutamate racemase
UniProt: P22634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11204
Length: 285 (250)
Sequences: 3608 (2457)
Seq/√Len: 155.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_V40_I3.7601.00
52_A258_A3.4591.00
180_L216_Q3.4141.00
87_L235_T3.4041.00
73_V106_K2.9191.00
39_E42_H2.7681.00
37_Y49_Y2.7101.00
57_A71_R2.6271.00
85_L88_A2.5891.00
129_I156_Q2.4131.00
47_L86_A2.4111.00
78_A256_C2.3611.00
76_V88_A2.3461.00
211_Q215_L2.3281.00
145_H159_M2.3181.00
234_R237_W2.3161.00
169_A210_L2.2681.00
165_M183_L2.1251.00
40_I49_Y2.1151.00
82_R254_A2.1101.00
129_I158_E2.1051.00
43_L236_A2.0971.00
78_A82_R1.9751.00
89_V235_T1.9391.00
134_A139_V1.9251.00
22_P84_P1.9091.00
23_T86_A1.9041.00
133_L200_V1.8981.00
77_T106_K1.8051.00
40_I235_T1.7861.00
139_V159_M1.7441.00
90_V100_L1.7361.00
191_L218_L1.7001.00
128_G152_A1.6931.00
136_R140_K1.6931.00
180_L213_E1.6491.00
200_V218_L1.6451.00
160_L186_I1.6451.00
131_G197_P1.6411.00
173_L176_E1.6371.00
69_V102_A1.6201.00
57_A74_A1.6071.00
68_I137_G1.5961.00
107_F111_V1.5741.00
52_A75_I1.5671.00
100_L113_G1.5601.00
129_I196_P1.5261.00
160_L189_P1.5141.00
112_V238_L1.4941.00
211_Q226_D1.4911.00
26_V37_Y1.4731.00
80_Q109_F1.4631.00
41_R253_I1.4471.00
214_L224_L1.4431.00
208_P228_G1.4341.00
77_T107_F1.4271.00
142_S145_H1.4151.00
40_I89_V1.4041.00
125_T198_D1.4041.00
71_R74_A1.4021.00
70_E74_A1.3981.00
39_E229_A1.3921.00
173_L178_V1.3871.00
76_V103_L1.3831.00
142_S159_M1.3821.00
166_V207_F1.3811.00
119_K234_R1.3771.00
67_F71_R1.3681.00
183_L217_V1.3651.00
73_V102_A1.3651.00
184_K188_R1.3591.00
125_T155_C1.3541.00
218_L222_T1.3491.00
143_Y147_L1.3311.00
132_L157_I1.3241.00
131_G190_W1.3241.00
65_E98_V1.3131.00
23_T47_L1.2981.00
37_Y253_I1.2921.00
164_E167_E1.2891.00
215_L224_L1.2881.00
164_E185_R1.2771.00
63_K71_R1.2541.00
148_I157_I1.2411.00
35_S209_L1.2211.00
125_T128_G1.2211.00
118_I148_I1.2191.00
87_L112_V1.2161.00
48_H252_N1.2051.00
37_Y40_I1.1941.00
90_V103_L1.1921.00
167_E207_F1.1891.00
180_L217_V1.1851.00
176_E179_S1.1851.00
62_E136_R1.1781.00
183_L186_I1.1741.00
168_L179_S1.1641.00
25_L85_L1.1581.00
180_L184_K1.1551.00
40_I232_A1.1521.00
145_H149_A1.1461.00
142_S146_E1.1431.00
229_A233_R1.1311.00
64_S67_F1.1301.00
88_A109_F1.1291.00
125_T199_T1.1241.00
128_G154_E1.1211.00
264_E268_P1.1201.00
86_A244_P1.1141.00
144_T159_M1.1141.00
211_Q224_L1.1060.99
238_L242_E1.1040.99
67_F70_E1.0900.99
36_V231_I1.0890.99
23_T48_H1.0880.99
41_R49_Y1.0850.99
236_A240_E1.0840.99
146_E150_R1.0820.99
139_V161_G1.0790.99
162_S207_F1.0770.99
24_V47_L1.0710.99
177_D181_D1.0580.99
164_E207_F1.0550.99
188_R194_K1.0550.99
63_K67_F1.0510.99
234_R238_L1.0460.99
44_L236_A1.0460.99
199_T223_R1.0360.99
38_D272_R1.0320.99
55_N257_M1.0200.99
98_V137_G1.0070.99
39_E228_G1.0070.99
213_E216_Q1.0060.99
148_I201_V1.0050.99
227_S230_A0.9980.99
215_L220_E0.9980.99
115_V143_Y0.9960.99
47_L244_P0.9940.99
127_N198_D0.9920.99
120_P123_R0.9910.99
183_L214_L0.9900.99
103_L111_V0.9890.99
100_L104_R0.9780.99
118_I147_L0.9780.99
35_S208_P0.9710.99
48_H251_A0.9700.99
200_V224_L0.9590.99
21_R247_K0.9530.98
129_I197_P0.9520.98
240_E245_D0.9420.98
164_E182_A0.9420.98
127_N199_T0.9390.98
124_L225_V0.9380.98
76_V111_V0.9370.98
169_A179_S0.9350.98
120_P230_A0.9330.98
181_D184_K0.9320.98
23_T50_I0.9290.98
21_R246_A0.9240.98
43_L233_R0.9220.98
183_L213_E0.9160.98
176_E180_L0.9140.98
136_R161_G0.9110.98
169_A207_F0.9100.98
131_G200_V0.9080.98
214_L217_V0.9050.98
104_R147_L0.9000.98
96_S113_G0.8990.98
164_E186_I0.8970.98
237_W241_H0.8960.98
89_V112_V0.8940.98
72_V95_A0.8930.98
130_V155_C0.8900.98
184_K217_V0.8880.98
146_E149_A0.8790.97
76_V99_S0.8780.97
62_E207_F0.8770.97
71_R75_I0.8760.97
68_I72_V0.8760.97
86_A239_L0.8730.97
66_A70_E0.8700.97
72_V75_I0.8680.97
62_E137_G0.8650.97
39_E232_A0.8640.97
199_T225_V0.8630.97
48_H246_A0.8570.97
218_L224_L0.8560.97
44_L47_L0.8550.97
51_Y55_N0.8450.97
43_L232_A0.8440.97
27_F76_V0.8410.97
65_E69_V0.8360.97
102_A106_K0.8360.97
80_Q107_F0.8340.96
77_T81_E0.8330.96
96_S100_L0.8260.96
158_E195_E0.8110.96
182_A186_I0.8100.96
112_V235_T0.8040.96
144_T148_I0.8010.96
179_S210_L0.7990.95
31_V266_L0.7960.95
101_P105_E0.7940.95
263_A267_L0.7920.95
55_N58_F0.7890.95
27_F75_I0.7850.95
124_L223_R0.7840.95
266_L270_L0.7790.95
114_V231_I0.7780.95
191_L217_V0.7770.95
179_S213_E0.7750.95
212_E215_L0.7740.95
47_L239_L0.7720.95
147_L150_R0.7710.95
80_Q111_V0.7700.95
96_S115_V0.7680.94
25_L79_V0.7680.94
82_R256_C0.7620.94
37_Y41_R0.7580.94
26_V232_A0.7530.94
117_A121_A0.7520.94
102_A105_E0.7510.94
99_S103_L0.7490.94
117_A227_S0.7430.93
139_V144_T0.7410.93
125_T130_V0.7380.93
58_F166_V0.7370.93
261_P265_Q0.7360.93
254_A257_M0.7350.93
178_V182_A0.7330.93
117_A120_P0.7330.93
115_V144_T0.7320.93
168_L182_A0.7290.93
166_V170_E0.7290.93
133_L214_L0.7250.93
118_I144_T0.7220.92
103_L107_F0.7210.92
38_D42_H0.7170.92
58_F257_M0.7080.92
81_E84_P0.7070.92
100_L115_V0.7050.91
254_A258_A0.7050.91
57_A63_K0.7040.91
174_H179_S0.7010.91
239_L245_D0.7000.91
137_G141_R0.6990.91
219_P222_T0.6990.91
57_A67_F0.6980.91
197_P200_V0.6930.91
168_L210_L0.6900.91
132_L201_V0.6790.90
88_A111_V0.6780.90
132_L139_V0.6740.90
120_P124_L0.6700.89
267_L271_Q0.6670.89
197_P218_L0.6630.89
183_L187_L0.6610.89
95_A116_P0.6600.89
101_P146_E0.6560.88
267_L270_L0.6550.88
166_V227_S0.6550.88
48_H253_I0.6540.88
28_D32_G0.6530.88
94_T135_T0.6500.88
104_R119_K0.6480.88
41_R273_Y0.6470.88
27_F51_Y0.6450.87
67_F259_M0.6440.87
213_E217_V0.6440.87
50_I256_C0.6430.87
230_A233_R0.6420.87
148_I155_C0.6390.87
184_K191_L0.6370.87
249_A252_N0.6350.87
79_V88_A0.6330.86
181_D185_R0.6300.86
48_H250_D0.6250.86
50_I79_V0.6230.86
73_V77_T0.6200.85
39_E43_L0.6190.85
76_V80_Q0.6180.85
197_P222_T0.6170.85
163_A207_F0.6130.85
69_V73_V0.6130.85
21_R48_H0.6110.84
53_F259_M0.6100.84
73_V76_V0.6100.84
187_L214_L0.6090.84
253_I257_M0.6090.84
164_E173_L0.6080.84
128_G155_C0.6040.84
165_M210_L0.6040.84
44_L86_A0.6040.84
58_F63_K0.6020.84
100_L147_L0.5990.83
67_F171_A0.5950.83
246_A249_A0.5890.82
80_Q108_D0.5880.82
72_V90_V0.5870.82
119_K151_F0.5870.82
156_Q195_E0.5870.82
255_F263_A0.5840.82
122_A152_A0.5830.82
72_V103_L0.5800.81
264_E267_L0.5800.81
27_F72_V0.5800.81
228_G270_L0.5780.81
114_V117_A0.5760.81
177_D180_L0.5750.81
86_A243_A0.5750.81
238_L241_H0.5740.81
78_A81_E0.5700.80
35_S228_G0.5680.80
215_L223_R0.5680.80
46_D248_S0.5680.80
63_K72_V0.5600.79
259_M262_G0.5600.79
87_L238_L0.5580.79
36_V208_P0.5560.79
113_G117_A0.5530.78
97_T141_R0.5510.78
126_A223_R0.5510.78
212_E216_Q0.5480.78
29_S33_G0.5460.77
122_A151_F0.5460.77
231_I234_R0.5440.77
261_P264_E0.5430.77
246_A252_N0.5420.77
46_D247_K0.5380.76
119_K147_L0.5380.76
175_G216_Q0.5380.76
48_H254_A0.5370.76
158_E197_P0.5340.76
97_T143_Y0.5340.76
236_A245_D0.5330.76
62_E166_V0.5300.75
119_K230_A0.5300.75
121_A198_D0.5300.75
104_R115_V0.5270.75
175_G213_E0.5260.75
92_C204_C0.5260.75
41_R271_Q0.5240.74
73_V88_A0.5240.74
114_V227_S0.5230.74
72_V76_V0.5210.74
35_S71_R0.5190.74
171_A259_M0.5190.74
86_A245_D0.5190.74
133_L162_S0.5180.74
135_T204_C0.5180.74
48_H86_A0.5160.73
265_Q268_P0.5160.73
166_V210_L0.5150.73
117_A230_A0.5150.73
99_S158_E0.5140.73
162_S165_M0.5130.73
243_A246_A0.5120.73
154_E268_P0.5120.73
137_G228_G0.5110.73
162_S186_I0.5110.73
257_M263_A0.5100.72
72_V99_S0.5100.72
248_S251_A0.5080.72
121_A130_V0.5080.72
49_Y253_I0.5070.72
175_G212_E0.5070.72
26_V114_V0.5070.72
21_R250_D0.5070.72
116_P227_S0.5060.72
172_K213_E0.5040.72
126_A198_D0.5030.71
190_W197_P0.5010.71
112_V231_I0.5010.71
209_L266_L0.5000.71
93_N97_T0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dwuA 2 0.9228 100 0.266 Contact Map
1zuwA 2 0.9088 100 0.282 Contact Map
2jfnA 1 0.9298 100 0.289 Contact Map
2gzmA 3 0.9228 100 0.313 Contact Map
2vvtA 2 0.9404 100 0.317 Contact Map
2jfqA 2 0.9158 100 0.321 Contact Map
2ohoA 2 0.9439 100 0.331 Contact Map
3istA 2 0.9333 100 0.332 Contact Map
3outA 5 0.9088 100 0.335 Contact Map
3uhfA 1 0.8842 100 0.371 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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