GREMLIN Database
FLIO - Flagellar protein FliO
UniProt: P22586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11224
Length: 121 (107)
Sequences: 617 (439)
Seq/√Len: 42.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_T87_I4.8131.00
71_V80_L3.7521.00
72_D75_D3.2461.00
32_I36_A2.7151.00
69_V80_L2.5521.00
69_V82_V2.5411.00
68_V80_L2.4921.00
57_S70_V2.4131.00
77_R97_A2.3511.00
29_I33_L2.3221.00
72_D77_R2.3181.00
77_R96_S2.3121.00
76_A92_K2.2961.00
68_V71_V2.1731.00
62_L68_V2.1170.99
68_V87_I2.1010.99
83_T86_Q1.8700.99
62_L80_L1.8610.99
54_L60_A1.8100.98
77_R93_L1.7980.98
23_G30_A1.7910.98
82_V87_I1.7590.98
89_L92_K1.7170.97
24_A28_I1.6600.97
79_V95_P1.5080.95
77_R95_P1.4760.94
78_L91_H1.4720.94
76_A91_H1.4670.94
78_L89_L1.4430.93
37_W43_G1.3620.91
83_T88_N1.3260.90
23_G109_S1.3220.90
54_L70_V1.2800.88
79_V93_L1.2200.86
76_A96_S1.1830.84
42_L66_E1.1500.82
36_A39_V1.1310.81
13_V54_L1.1200.80
106_D114_L1.1000.79
31_L114_L1.0920.79
79_V97_A1.0750.77
24_A27_A1.0740.77
21_V31_L1.0370.75
76_A94_P1.0350.75
43_G105_T1.0260.74
27_A31_L1.0000.72
74_E77_R0.9980.72
57_S72_D0.9950.72
110_V114_L0.9690.70
56_I82_V0.9200.66
68_V79_V0.9200.66
32_I91_H0.9190.66
80_L87_I0.9030.64
45_A61_S0.8950.63
15_A38_L0.8930.63
61_S85_G0.8790.62
29_I40_K0.8770.62
75_D95_P0.8760.62
64_A67_R0.8760.62
36_A75_D0.8360.58
54_L73_V0.8320.58
59_S85_G0.8290.58
67_R96_S0.8260.57
40_K90_L0.8230.57
98_P101_E0.8150.56
16_A84_A0.8110.56
60_A68_V0.8030.55
56_I71_V0.8000.55
37_W78_L0.7850.53
41_R96_S0.7820.53
112_K116_K0.7810.53
78_L108_Q0.7750.52
65_R70_V0.7660.52
29_I34_A0.7650.52
60_A87_I0.7570.51
32_I52_N0.7560.51
16_A31_L0.7520.50
44_F59_S0.7500.50
68_V82_V0.7490.50
30_A43_G0.7440.50
32_I110_V0.7430.49
43_G79_V0.7210.47
43_G78_L0.7150.47
63_G66_E0.7140.47
20_Q43_G0.7030.46
49_T101_E0.6990.45
65_R103_P0.6950.45
35_A68_V0.6900.44
28_I77_R0.6800.44
26_I99_T0.6750.43
72_D79_V0.6720.43
15_A37_W0.6700.43
55_K93_L0.6690.43
86_Q90_L0.6660.42
19_L92_K0.6580.41
71_V78_L0.6570.41
96_S112_K0.6520.41
15_A27_A0.6490.41
77_R92_K0.6490.41
18_L22_S0.6470.40
30_A110_V0.6470.40
72_D88_N0.6420.40
30_A42_L0.6410.40
10_S69_V0.6410.40
48_R61_S0.6350.39
26_I88_N0.6350.39
26_I42_L0.6350.39
70_V79_V0.6320.39
98_P113_N0.6300.39
41_R63_G0.6260.39
107_F111_M0.6250.39
71_V88_N0.6240.38
54_L94_P0.6220.38
33_L95_P0.6130.37
23_G110_V0.6080.37
70_V73_V0.6070.37
76_A95_P0.6020.36
15_A114_L0.5990.36
51_V82_V0.5980.36
31_L105_T0.5970.36
15_A20_Q0.5950.36
42_L98_P0.5930.36
65_R106_D0.5860.35
53_G70_V0.5840.35
87_I109_S0.5830.35
22_S114_L0.5810.35
14_S113_N0.5800.35
17_P73_V0.5780.34
78_L117_R0.5760.34
15_A65_R0.5750.34
53_G116_K0.5660.33
65_R89_L0.5650.33
84_A89_L0.5630.33
25_L63_G0.5630.33
16_A58_A0.5600.33
49_T99_T0.5600.33
24_A115_L0.5550.32
64_A69_V0.5470.32
84_A98_P0.5450.32
110_V113_N0.5440.32
75_D94_P0.5400.31
28_I87_I0.5380.31
46_P80_L0.5350.31
110_V116_K0.5280.30
62_L87_I0.5270.30
18_L30_A0.5270.30
42_L110_V0.5260.30
60_A90_L0.5250.30
38_L49_T0.5240.30
15_A18_L0.5230.30
40_K97_A0.5220.30
62_L83_T0.5160.29
21_V41_R0.5160.29
55_K60_A0.5110.29
40_K105_T0.5110.29
13_V24_A0.5080.29
39_V100_E0.5060.29
43_G65_R0.5010.28
27_A30_A0.5000.28
21_V54_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nlyA 1 0.4298 30.3 0.916 Contact Map
2l2tA 2 0.3636 21.7 0.922 Contact Map
2h3gX 2 0.438 15.9 0.927 Contact Map
2jwaA 2 0.3636 14.6 0.928 Contact Map
2ks1B 1 0.3636 13.9 0.929 Contact Map
1iijA 1 0.2893 13.2 0.929 Contact Map
3djcA 5 0.438 12.5 0.93 Contact Map
2ww8A 1 0.0744 11.7 0.931 Contact Map
4u98A 1 0.7521 11.1 0.932 Contact Map
4qmkA 2 0.9669 9.1 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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