RIHC - ECOLI - GREMLIN Contacts

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RIHC - Non-specific ribonucleoside hydrolase RihC

UniProt:	P22564	Sequences: MRLPIFLDTDPGIDDAVAIAAAIFAPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNAEIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPAFLAIRDALMRAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAAACVFRSGIEIVMCGLDVTNQAILTPDYLSTLPQLNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPDLFTLKPCFVAVETQGEFTSGTTVVDIDGCLGKPANVQVALDLDVKGFQQWVAEVLALAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11082
Length:	304 (296)
Sequences:	3862 (2750)
Seq/√Len:	159.9

ECOLI - RIHC RIHB RIHA
SULSO - Q97WH6 Q97ZS5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_I	109_D	3.928	1.00
105_L	135_Q	3.635	1.00
174_A	178_R	3.204	1.00
248_T	286_D	2.894	1.00
4_P	29_D	2.892	1.00
134_S	175_C	2.881	1.00
166_I	267_T	2.717	1.00
32_L	106_A	2.560	1.00
193_Q	286_D	2.470	1.00
66_A	131_L	2.462	1.00
112_M	136_C	2.384	1.00
174_A	255_A	2.381	1.00
35_T	46_T	2.353	1.00
251_P	282_Q	2.295	1.00
243_R	291_G	2.264	1.00
112_M	142_Y	2.198	1.00
121_V	238_I	2.178	1.00
109_D	113_R	2.143	1.00
3_L	145_R	2.118	1.00
7_L	123_I	2.116	1.00
133_L	140_K	2.114	1.00
22_A	238_I	2.068	1.00
19_I	33_M	2.056	1.00
11_P	49_A	2.052	1.00
4_P	31_Q	2.052	1.00
112_M	138_E	2.029	1.00
34_T	103_A	2.011	1.00
166_I	173_A	1.973	1.00
161_N	266_T	1.939	1.00
191_T	233_H	1.927	1.00
117_P	144_R	1.911	1.00
249_L	284_A	1.910	1.00
108_R	136_C	1.905	1.00
288_D	291_G	1.891	1.00
50_L	62_L	1.853	1.00
122_A	129_I	1.850	1.00
63_A	106_A	1.845	1.00
257_E	263_T	1.816	1.00
122_A	148_I	1.806	1.00
111_L	118_V	1.795	1.00
31_Q	118_V	1.735	1.00
145_R	184_V	1.717	1.00
20_A	56_W	1.705	1.00
232_M	235_L	1.662	1.00
72_R	264_S	1.661	1.00
5_I	121_V	1.646	1.00
6_F	34_T	1.629	1.00
132_L	136_C	1.625	1.00
42_V	64_Q	1.617	1.00
122_A	126_L	1.617	1.00
23_I	30_L	1.614	1.00
108_R	132_L	1.607	1.00
47_R	51_Q	1.596	1.00
3_L	144_R	1.574	1.00
119_T	147_V	1.565	1.00
63_A	99_L	1.558	1.00
106_A	110_A	1.540	1.00
8_D	128_N	1.536	1.00
9_T	123_I	1.523	1.00
25_A	299_V	1.521	1.00
102_P	105_L	1.515	1.00
148_I	185_M	1.508	1.00
53_L	60_I	1.505	1.00
111_L	142_Y	1.489	1.00
108_R	139_C	1.484	1.00
246_L	291_G	1.477	1.00
294_Q	298_E	1.476	1.00
126_L	176_V	1.471	1.00
240_W	247_F	1.466	1.00
205_P	215_H	1.455	1.00
84_S	90_D	1.437	1.00
212_K	216_A	1.436	1.00
129_I	146_L	1.436	1.00
148_I	177_F	1.430	1.00
132_L	139_C	1.423	1.00
171_E	264_S	1.421	1.00
186_C	284_A	1.421	1.00
148_I	166_I	1.405	1.00
136_C	139_C	1.403	1.00
111_L	132_L	1.391	1.00
50_L	97_K	1.363	1.00
102_P	135_Q	1.353	1.00
82_G	85_G	1.353	1.00
110_A	113_R	1.349	1.00
166_I	177_F	1.349	1.00
72_R	171_E	1.328	1.00
184_V	282_Q	1.327	1.00
107_I	132_L	1.323	1.00
119_T	145_R	1.322	1.00
257_E	260_G	1.316	1.00
43_E	64_Q	1.311	1.00
290_K	294_Q	1.302	1.00
203_T	294_Q	1.301	1.00
257_E	261_E	1.292	1.00
239_A	292_F	1.290	1.00
54_H	96_R	1.290	1.00
4_P	114_A	1.278	1.00
114_A	117_P	1.271	1.00
9_T	49_A	1.270	1.00
3_L	119_T	1.265	1.00
42_V	46_T	1.262	1.00
47_R	93_E	1.260	1.00
126_L	148_I	1.243	1.00
260_G	263_T	1.234	1.00
21_A	295_W	1.231	1.00
46_T	64_Q	1.227	1.00
121_V	241_L	1.226	1.00
150_G	166_I	1.224	1.00
23_I	60_I	1.218	1.00
110_A	118_V	1.213	1.00
174_A	258_T	1.211	1.00
7_L	30_L	1.203	1.00
239_A	295_W	1.200	1.00
55_F	213_M	1.199	1.00
115_P	142_Y	1.194	1.00
263_T	268_V	1.187	1.00
70_L	130_A	1.178	1.00
25_A	242_V	1.174	1.00
249_L	282_Q	1.170	1.00
6_F	32_L	1.170	1.00
30_L	123_I	1.168	1.00
81_H	85_G	1.163	1.00
105_L	109_D	1.160	1.00
184_V	249_L	1.159	1.00
111_L	143_I	1.155	1.00
200_Y	293_Q	1.150	1.00
177_F	185_M	1.138	1.00
7_L	22_A	1.133	1.00
71_V	171_E	1.131	1.00
250_K	285_L	1.128	1.00
236_C	247_F	1.126	1.00
40_V	44_K	1.126	1.00
27_E	299_V	1.125	1.00
145_R	182_E	1.121	1.00
111_L	139_C	1.116	1.00
203_T	297_A	1.113	1.00
104_F	135_Q	1.104	1.00
159_T	162_A	1.104	1.00
84_S	87_A	1.094	1.00
236_C	287_L	1.093	1.00
252_C	283_V	1.090	0.99
120_L	143_I	1.089	0.99
195_I	229_G	1.077	0.99
252_C	269_V	1.076	0.99
143_I	181_I	1.075	0.99
263_T	266_T	1.065	0.99
104_F	132_L	1.064	0.99
107_I	139_C	1.062	0.99
184_V	240_W	1.062	0.99
96_R	99_L	1.057	0.99
254_V	281_V	1.056	0.99
68_V	134_S	1.053	0.99
35_T	49_A	1.041	0.99
54_H	95_N	1.037	0.99
7_L	19_I	1.032	0.99
33_M	53_L	1.018	0.99
46_T	98_P	1.013	0.99
107_I	111_L	1.004	0.99
121_V	237_A	0.992	0.99
153_A	187_G	0.990	0.99
21_A	299_V	0.987	0.99
147_V	240_W	0.985	0.99
245_D	291_G	0.983	0.99
146_L	181_I	0.983	0.99
41_S	44_K	0.982	0.99
141_P	144_R	0.980	0.99
147_V	241_L	0.980	0.99
122_A	146_L	0.973	0.99
83_E	88_G	0.969	0.99
31_Q	110_A	0.964	0.99
17_V	296_V	0.960	0.99
253_F	277_K	0.958	0.99
243_R	295_W	0.957	0.99
149_M	191_T	0.957	0.99
13_I	221_Y	0.956	0.99
237_A	241_L	0.955	0.99
108_R	112_M	0.953	0.99
194_A	287_L	0.951	0.99
54_H	94_H	0.948	0.99
205_P	219_S	0.938	0.98
53_L	62_L	0.936	0.98
107_I	129_I	0.927	0.98
80_V	224_G	0.926	0.98
153_A	185_M	0.926	0.98
200_Y	297_A	0.921	0.98
197_T	200_Y	0.920	0.98
111_L	114_A	0.919	0.98
202_S	206_Q	0.902	0.98
4_P	117_P	0.901	0.98
37_A	168_A	0.897	0.98
170_P	264_S	0.896	0.98
240_W	249_L	0.895	0.98
16_A	52_L	0.893	0.98
198_P	202_S	0.891	0.98
120_L	129_I	0.884	0.98
6_F	107_I	0.882	0.98
138_E	141_P	0.882	0.98
182_E	282_Q	0.880	0.98
84_S	88_G	0.880	0.98
238_I	241_L	0.880	0.98
162_A	167_A	0.879	0.98
177_F	183_I	0.877	0.98
40_V	45_T	0.875	0.98
6_F	118_V	0.873	0.98
239_A	246_L	0.867	0.97
22_A	28_L	0.864	0.97
146_L	183_I	0.864	0.97
133_L	179_S	0.861	0.97
23_I	53_L	0.861	0.97
11_P	45_T	0.856	0.97
148_I	183_I	0.856	0.97
178_R	255_A	0.854	0.97
164_F	168_A	0.850	0.97
5_I	28_L	0.848	0.97
131_L	134_S	0.846	0.97
63_A	101_I	0.844	0.97
253_F	280_N	0.842	0.97
119_T	144_R	0.837	0.97
70_L	131_L	0.835	0.97
6_F	106_A	0.828	0.97
34_T	128_N	0.828	0.97
156_G	162_A	0.826	0.97
43_E	67_A	0.826	0.97
71_V	175_C	0.826	0.97
35_T	45_T	0.825	0.97
256_V	267_T	0.818	0.96
125_P	168_A	0.816	0.96
126_L	173_A	0.814	0.96
294_Q	297_A	0.805	0.96
108_R	135_Q	0.804	0.96
186_C	240_W	0.803	0.96
291_G	295_W	0.803	0.96
117_P	142_Y	0.803	0.96
254_V	267_T	0.797	0.96
208_N	211_G	0.796	0.96
66_A	127_T	0.793	0.96
163_E	188_L	0.793	0.96
75_R	167_A	0.790	0.96
237_A	240_W	0.784	0.95
28_L	242_V	0.782	0.95
66_A	102_P	0.782	0.95
185_M	283_V	0.781	0.95
64_Q	98_P	0.780	0.95
34_T	107_I	0.780	0.95
147_V	237_A	0.779	0.95
32_L	110_A	0.777	0.95
76_D	168_A	0.774	0.95
22_A	121_V	0.770	0.95
159_T	167_A	0.768	0.95
187_G	190_V	0.768	0.95
111_L	140_K	0.767	0.95
46_T	50_L	0.766	0.95
54_H	58_A	0.760	0.95
39_N	48_N	0.760	0.95
21_A	239_A	0.756	0.94
20_A	52_L	0.752	0.94
115_P	118_V	0.751	0.94
207_L	211_G	0.749	0.94
253_F	279_A	0.748	0.94
152_S	155_R	0.747	0.94
133_L	181_I	0.746	0.94
104_F	131_L	0.745	0.94
79_S	158_C	0.743	0.94
31_Q	114_A	0.740	0.94
12_G	16_A	0.739	0.94
213_M	217_L	0.739	0.94
188_L	233_H	0.731	0.93
44_K	47_R	0.731	0.93
42_V	45_T	0.726	0.93
56_W	210_T	0.724	0.93
50_L	96_R	0.718	0.93
171_E	258_T	0.718	0.93
8_D	34_T	0.718	0.93
126_L	166_I	0.717	0.93
39_N	81_H	0.716	0.93
70_L	175_C	0.714	0.93
289_V	293_Q	0.713	0.92
149_M	234_D	0.713	0.92
243_R	246_L	0.713	0.92
133_L	143_I	0.712	0.92
20_A	214_L	0.710	0.92
23_I	56_W	0.709	0.92
6_F	110_A	0.704	0.92
13_I	87_A	0.703	0.92
82_G	87_A	0.703	0.92
177_F	267_T	0.702	0.92
77_A	80_V	0.701	0.92
171_E	259_Q	0.697	0.92
33_M	49_A	0.697	0.92
81_H	87_A	0.694	0.91
186_C	249_L	0.693	0.91
154_G	189_D	0.692	0.91
247_F	284_A	0.688	0.91
236_C	292_F	0.687	0.91
194_A	292_F	0.686	0.91
114_A	118_V	0.683	0.91
111_L	136_C	0.682	0.91
157_N	188_L	0.681	0.91
116_E	144_R	0.680	0.91
35_T	128_N	0.680	0.91
95_N	98_P	0.680	0.91
248_T	288_D	0.675	0.90
70_L	172_A	0.673	0.90
113_R	116_E	0.673	0.90
205_P	212_K	0.673	0.90
186_C	237_A	0.672	0.90
195_I	231_R	0.670	0.90
295_W	299_V	0.670	0.90
251_P	280_N	0.669	0.90
120_L	146_L	0.664	0.90
36_V	124_G	0.663	0.89
185_M	267_T	0.661	0.89
145_R	244_P	0.661	0.89
53_L	58_A	0.656	0.89
51_Q	94_H	0.653	0.89
19_I	22_A	0.652	0.89
119_T	241_L	0.652	0.89
18_A	238_I	0.651	0.89
34_T	106_A	0.650	0.89
84_S	89_Y	0.649	0.88
52_L	213_M	0.648	0.88
17_V	214_L	0.648	0.88
70_L	134_S	0.644	0.88
139_C	142_Y	0.644	0.88
129_I	143_I	0.637	0.88
158_C	167_A	0.637	0.88
116_E	142_Y	0.637	0.88
145_R	282_Q	0.636	0.87
36_V	128_N	0.635	0.87
32_L	63_A	0.634	0.87
240_W	284_A	0.630	0.87
74_P	168_A	0.629	0.87
175_C	178_R	0.628	0.87
105_L	108_R	0.626	0.87
253_F	275_L	0.626	0.87
209_R	212_K	0.622	0.86
102_P	131_L	0.621	0.86
246_L	295_W	0.620	0.86
153_A	189_D	0.619	0.86
200_Y	289_V	0.617	0.86
14_D	234_D	0.617	0.86
111_L	115_P	0.615	0.86
153_A	285_L	0.614	0.86
30_L	33_M	0.613	0.86
126_L	129_I	0.611	0.85
147_V	186_C	0.609	0.85
103_A	128_N	0.608	0.85
48_N	82_G	0.608	0.85
114_A	142_Y	0.607	0.85
15_D	234_D	0.605	0.85
145_R	240_W	0.604	0.85
157_N	163_E	0.604	0.85
140_K	143_I	0.601	0.84
24_F	299_V	0.600	0.84
260_G	264_S	0.597	0.84
123_I	148_I	0.597	0.84
140_K	181_I	0.595	0.84
19_I	23_I	0.593	0.84
104_F	108_R	0.591	0.83
200_Y	203_T	0.590	0.83
139_C	143_I	0.588	0.83
295_W	298_E	0.585	0.83
192_N	233_H	0.585	0.83
202_S	205_P	0.583	0.83
270_D	273_G	0.582	0.82
47_R	94_H	0.582	0.82
37_A	164_F	0.581	0.82
157_N	162_A	0.579	0.82
41_S	76_D	0.577	0.82
64_Q	67_A	0.577	0.82
172_A	176_V	0.576	0.82
205_P	216_A	0.575	0.82
132_L	135_Q	0.575	0.82
153_A	269_V	0.575	0.82
215_H	219_S	0.574	0.82
56_W	214_L	0.574	0.82
222_R	230_L	0.574	0.82
149_M	233_H	0.572	0.81
101_I	106_A	0.572	0.81
154_G	192_N	0.569	0.81
152_S	189_D	0.568	0.81
254_V	283_V	0.563	0.80
150_G	173_A	0.563	0.80
28_L	241_L	0.562	0.80
136_C	142_Y	0.559	0.80
12_G	233_H	0.557	0.80
51_Q	55_F	0.555	0.79
214_L	300_L	0.555	0.79
25_A	295_W	0.553	0.79
80_V	88_G	0.553	0.79
21_A	238_I	0.553	0.79
249_L	285_L	0.553	0.79
214_L	217_L	0.548	0.79
70_L	127_T	0.548	0.79
252_C	285_L	0.548	0.79
105_L	136_C	0.548	0.79
123_I	237_A	0.547	0.78
42_V	67_A	0.545	0.78
108_R	138_E	0.544	0.78
173_A	176_V	0.543	0.78
5_I	241_L	0.542	0.78
68_V	73_A	0.542	0.78
85_G	88_G	0.542	0.78
133_L	139_C	0.541	0.78
71_V	134_S	0.538	0.77
276_G	279_A	0.535	0.77
110_A	114_A	0.533	0.77
50_L	98_P	0.532	0.77
53_L	59_E	0.531	0.76
250_K	271_I	0.531	0.76
101_I	105_L	0.530	0.76
28_L	121_V	0.529	0.76
133_L	175_C	0.529	0.76
248_T	251_P	0.528	0.76
190_V	287_L	0.528	0.76
5_I	22_A	0.528	0.76
104_F	111_L	0.527	0.76
213_M	218_F	0.526	0.76
6_F	31_Q	0.524	0.75
71_V	174_A	0.524	0.75
216_A	219_S	0.523	0.75
200_Y	204_L	0.523	0.75
51_Q	91_F	0.521	0.75
35_T	64_Q	0.521	0.75
221_Y	233_H	0.516	0.74
201_L	219_S	0.515	0.74
196_L	230_L	0.515	0.74
140_K	180_G	0.513	0.74
131_L	135_Q	0.512	0.74
106_A	109_D	0.511	0.74
69_P	72_R	0.509	0.73
23_I	58_A	0.508	0.73
199_D	202_S	0.507	0.73
30_L	60_I	0.506	0.73
15_D	18_A	0.506	0.73
130_A	175_C	0.505	0.73
141_P	145_R	0.505	0.73
23_I	26_P	0.505	0.73
217_L	221_Y	0.505	0.73
4_P	116_E	0.503	0.72
39_N	149_M	0.503	0.72
81_H	86_M	0.503	0.72
81_H	88_G	0.501	0.72
174_A	261_E	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wr2A	4	0.9671	100	0.059	Contact Map
1q8fA	4	0.9967	100	0.064	Contact Map
2masA	3	0.9967	100	0.074	Contact Map
3t8jA	3	0.9901	100	0.08	Contact Map
4kpoA	2	0.9934	100	0.081	Contact Map
4kpnA	2	0.9934	100	0.083	Contact Map
3t8iA	3	0.9803	100	0.103	Contact Map
3fz0A	3	0.9934	100	0.104	Contact Map
4i71A	2	0.9605	100	0.133	Contact Map
2c40A	2	0.9309	100	0.134	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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