GREMLIN Database
RIHC - Non-specific ribonucleoside hydrolase RihC
UniProt: P22564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11082
Length: 304 (296)
Sequences: 3862 (2750)
Seq/√Len: 159.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_I109_D3.9281.00
105_L135_Q3.6351.00
174_A178_R3.2041.00
248_T286_D2.8941.00
4_P29_D2.8921.00
134_S175_C2.8811.00
166_I267_T2.7171.00
32_L106_A2.5601.00
193_Q286_D2.4701.00
66_A131_L2.4621.00
112_M136_C2.3841.00
174_A255_A2.3811.00
35_T46_T2.3531.00
251_P282_Q2.2951.00
243_R291_G2.2641.00
112_M142_Y2.1981.00
121_V238_I2.1781.00
109_D113_R2.1431.00
3_L145_R2.1181.00
7_L123_I2.1161.00
133_L140_K2.1141.00
22_A238_I2.0681.00
19_I33_M2.0561.00
11_P49_A2.0521.00
4_P31_Q2.0521.00
112_M138_E2.0291.00
34_T103_A2.0111.00
166_I173_A1.9731.00
161_N266_T1.9391.00
191_T233_H1.9271.00
117_P144_R1.9111.00
249_L284_A1.9101.00
108_R136_C1.9051.00
288_D291_G1.8911.00
50_L62_L1.8531.00
122_A129_I1.8501.00
63_A106_A1.8451.00
257_E263_T1.8161.00
122_A148_I1.8061.00
111_L118_V1.7951.00
31_Q118_V1.7351.00
145_R184_V1.7171.00
20_A56_W1.7051.00
232_M235_L1.6621.00
72_R264_S1.6611.00
5_I121_V1.6461.00
6_F34_T1.6291.00
132_L136_C1.6251.00
42_V64_Q1.6171.00
122_A126_L1.6171.00
23_I30_L1.6141.00
108_R132_L1.6071.00
47_R51_Q1.5961.00
3_L144_R1.5741.00
119_T147_V1.5651.00
63_A99_L1.5581.00
106_A110_A1.5401.00
8_D128_N1.5361.00
9_T123_I1.5231.00
25_A299_V1.5211.00
102_P105_L1.5151.00
148_I185_M1.5081.00
53_L60_I1.5051.00
111_L142_Y1.4891.00
108_R139_C1.4841.00
246_L291_G1.4771.00
294_Q298_E1.4761.00
126_L176_V1.4711.00
240_W247_F1.4661.00
205_P215_H1.4551.00
84_S90_D1.4371.00
212_K216_A1.4361.00
129_I146_L1.4361.00
148_I177_F1.4301.00
132_L139_C1.4231.00
171_E264_S1.4211.00
186_C284_A1.4211.00
148_I166_I1.4051.00
136_C139_C1.4031.00
111_L132_L1.3911.00
50_L97_K1.3631.00
102_P135_Q1.3531.00
82_G85_G1.3531.00
110_A113_R1.3491.00
166_I177_F1.3491.00
72_R171_E1.3281.00
184_V282_Q1.3271.00
107_I132_L1.3231.00
119_T145_R1.3221.00
257_E260_G1.3161.00
43_E64_Q1.3111.00
290_K294_Q1.3021.00
203_T294_Q1.3011.00
257_E261_E1.2921.00
239_A292_F1.2901.00
54_H96_R1.2901.00
4_P114_A1.2781.00
114_A117_P1.2711.00
9_T49_A1.2701.00
3_L119_T1.2651.00
42_V46_T1.2621.00
47_R93_E1.2601.00
126_L148_I1.2431.00
260_G263_T1.2341.00
21_A295_W1.2311.00
46_T64_Q1.2271.00
121_V241_L1.2261.00
150_G166_I1.2241.00
23_I60_I1.2181.00
110_A118_V1.2131.00
174_A258_T1.2111.00
7_L30_L1.2031.00
239_A295_W1.2001.00
55_F213_M1.1991.00
115_P142_Y1.1941.00
263_T268_V1.1871.00
70_L130_A1.1781.00
25_A242_V1.1741.00
249_L282_Q1.1701.00
6_F32_L1.1701.00
30_L123_I1.1681.00
81_H85_G1.1631.00
105_L109_D1.1601.00
184_V249_L1.1591.00
111_L143_I1.1551.00
200_Y293_Q1.1501.00
177_F185_M1.1381.00
7_L22_A1.1331.00
71_V171_E1.1311.00
250_K285_L1.1281.00
236_C247_F1.1261.00
40_V44_K1.1261.00
27_E299_V1.1251.00
145_R182_E1.1211.00
111_L139_C1.1161.00
203_T297_A1.1131.00
104_F135_Q1.1041.00
159_T162_A1.1041.00
84_S87_A1.0941.00
236_C287_L1.0931.00
252_C283_V1.0900.99
120_L143_I1.0890.99
195_I229_G1.0770.99
252_C269_V1.0760.99
143_I181_I1.0750.99
263_T266_T1.0650.99
104_F132_L1.0640.99
107_I139_C1.0620.99
184_V240_W1.0620.99
96_R99_L1.0570.99
254_V281_V1.0560.99
68_V134_S1.0530.99
35_T49_A1.0410.99
54_H95_N1.0370.99
7_L19_I1.0320.99
33_M53_L1.0180.99
46_T98_P1.0130.99
107_I111_L1.0040.99
121_V237_A0.9920.99
153_A187_G0.9900.99
21_A299_V0.9870.99
147_V240_W0.9850.99
245_D291_G0.9830.99
146_L181_I0.9830.99
41_S44_K0.9820.99
141_P144_R0.9800.99
147_V241_L0.9800.99
122_A146_L0.9730.99
83_E88_G0.9690.99
31_Q110_A0.9640.99
17_V296_V0.9600.99
253_F277_K0.9580.99
243_R295_W0.9570.99
149_M191_T0.9570.99
13_I221_Y0.9560.99
237_A241_L0.9550.99
108_R112_M0.9530.99
194_A287_L0.9510.99
54_H94_H0.9480.99
205_P219_S0.9380.98
53_L62_L0.9360.98
107_I129_I0.9270.98
80_V224_G0.9260.98
153_A185_M0.9260.98
200_Y297_A0.9210.98
197_T200_Y0.9200.98
111_L114_A0.9190.98
202_S206_Q0.9020.98
4_P117_P0.9010.98
37_A168_A0.8970.98
170_P264_S0.8960.98
240_W249_L0.8950.98
16_A52_L0.8930.98
198_P202_S0.8910.98
120_L129_I0.8840.98
6_F107_I0.8820.98
138_E141_P0.8820.98
182_E282_Q0.8800.98
84_S88_G0.8800.98
238_I241_L0.8800.98
162_A167_A0.8790.98
177_F183_I0.8770.98
40_V45_T0.8750.98
6_F118_V0.8730.98
239_A246_L0.8670.97
22_A28_L0.8640.97
146_L183_I0.8640.97
133_L179_S0.8610.97
23_I53_L0.8610.97
11_P45_T0.8560.97
148_I183_I0.8560.97
178_R255_A0.8540.97
164_F168_A0.8500.97
5_I28_L0.8480.97
131_L134_S0.8460.97
63_A101_I0.8440.97
253_F280_N0.8420.97
119_T144_R0.8370.97
70_L131_L0.8350.97
6_F106_A0.8280.97
34_T128_N0.8280.97
156_G162_A0.8260.97
43_E67_A0.8260.97
71_V175_C0.8260.97
35_T45_T0.8250.97
256_V267_T0.8180.96
125_P168_A0.8160.96
126_L173_A0.8140.96
294_Q297_A0.8050.96
108_R135_Q0.8040.96
186_C240_W0.8030.96
291_G295_W0.8030.96
117_P142_Y0.8030.96
254_V267_T0.7970.96
208_N211_G0.7960.96
66_A127_T0.7930.96
163_E188_L0.7930.96
75_R167_A0.7900.96
237_A240_W0.7840.95
28_L242_V0.7820.95
66_A102_P0.7820.95
185_M283_V0.7810.95
64_Q98_P0.7800.95
34_T107_I0.7800.95
147_V237_A0.7790.95
32_L110_A0.7770.95
76_D168_A0.7740.95
22_A121_V0.7700.95
159_T167_A0.7680.95
187_G190_V0.7680.95
111_L140_K0.7670.95
46_T50_L0.7660.95
54_H58_A0.7600.95
39_N48_N0.7600.95
21_A239_A0.7560.94
20_A52_L0.7520.94
115_P118_V0.7510.94
207_L211_G0.7490.94
253_F279_A0.7480.94
152_S155_R0.7470.94
133_L181_I0.7460.94
104_F131_L0.7450.94
79_S158_C0.7430.94
31_Q114_A0.7400.94
12_G16_A0.7390.94
213_M217_L0.7390.94
188_L233_H0.7310.93
44_K47_R0.7310.93
42_V45_T0.7260.93
56_W210_T0.7240.93
50_L96_R0.7180.93
171_E258_T0.7180.93
8_D34_T0.7180.93
126_L166_I0.7170.93
39_N81_H0.7160.93
70_L175_C0.7140.93
289_V293_Q0.7130.92
149_M234_D0.7130.92
243_R246_L0.7130.92
133_L143_I0.7120.92
20_A214_L0.7100.92
23_I56_W0.7090.92
6_F110_A0.7040.92
13_I87_A0.7030.92
82_G87_A0.7030.92
177_F267_T0.7020.92
77_A80_V0.7010.92
171_E259_Q0.6970.92
33_M49_A0.6970.92
81_H87_A0.6940.91
186_C249_L0.6930.91
154_G189_D0.6920.91
247_F284_A0.6880.91
236_C292_F0.6870.91
194_A292_F0.6860.91
114_A118_V0.6830.91
111_L136_C0.6820.91
157_N188_L0.6810.91
116_E144_R0.6800.91
35_T128_N0.6800.91
95_N98_P0.6800.91
248_T288_D0.6750.90
70_L172_A0.6730.90
113_R116_E0.6730.90
205_P212_K0.6730.90
186_C237_A0.6720.90
195_I231_R0.6700.90
295_W299_V0.6700.90
251_P280_N0.6690.90
120_L146_L0.6640.90
36_V124_G0.6630.89
185_M267_T0.6610.89
145_R244_P0.6610.89
53_L58_A0.6560.89
51_Q94_H0.6530.89
19_I22_A0.6520.89
119_T241_L0.6520.89
18_A238_I0.6510.89
34_T106_A0.6500.89
84_S89_Y0.6490.88
52_L213_M0.6480.88
17_V214_L0.6480.88
70_L134_S0.6440.88
139_C142_Y0.6440.88
129_I143_I0.6370.88
158_C167_A0.6370.88
116_E142_Y0.6370.88
145_R282_Q0.6360.87
36_V128_N0.6350.87
32_L63_A0.6340.87
240_W284_A0.6300.87
74_P168_A0.6290.87
175_C178_R0.6280.87
105_L108_R0.6260.87
253_F275_L0.6260.87
209_R212_K0.6220.86
102_P131_L0.6210.86
246_L295_W0.6200.86
153_A189_D0.6190.86
200_Y289_V0.6170.86
14_D234_D0.6170.86
111_L115_P0.6150.86
153_A285_L0.6140.86
30_L33_M0.6130.86
126_L129_I0.6110.85
147_V186_C0.6090.85
103_A128_N0.6080.85
48_N82_G0.6080.85
114_A142_Y0.6070.85
15_D234_D0.6050.85
145_R240_W0.6040.85
157_N163_E0.6040.85
140_K143_I0.6010.84
24_F299_V0.6000.84
260_G264_S0.5970.84
123_I148_I0.5970.84
140_K181_I0.5950.84
19_I23_I0.5930.84
104_F108_R0.5910.83
200_Y203_T0.5900.83
139_C143_I0.5880.83
295_W298_E0.5850.83
192_N233_H0.5850.83
202_S205_P0.5830.83
270_D273_G0.5820.82
47_R94_H0.5820.82
37_A164_F0.5810.82
157_N162_A0.5790.82
41_S76_D0.5770.82
64_Q67_A0.5770.82
172_A176_V0.5760.82
205_P216_A0.5750.82
132_L135_Q0.5750.82
153_A269_V0.5750.82
215_H219_S0.5740.82
56_W214_L0.5740.82
222_R230_L0.5740.82
149_M233_H0.5720.81
101_I106_A0.5720.81
154_G192_N0.5690.81
152_S189_D0.5680.81
254_V283_V0.5630.80
150_G173_A0.5630.80
28_L241_L0.5620.80
136_C142_Y0.5590.80
12_G233_H0.5570.80
51_Q55_F0.5550.79
214_L300_L0.5550.79
25_A295_W0.5530.79
80_V88_G0.5530.79
21_A238_I0.5530.79
249_L285_L0.5530.79
214_L217_L0.5480.79
70_L127_T0.5480.79
252_C285_L0.5480.79
105_L136_C0.5480.79
123_I237_A0.5470.78
42_V67_A0.5450.78
108_R138_E0.5440.78
173_A176_V0.5430.78
5_I241_L0.5420.78
68_V73_A0.5420.78
85_G88_G0.5420.78
133_L139_C0.5410.78
71_V134_S0.5380.77
276_G279_A0.5350.77
110_A114_A0.5330.77
50_L98_P0.5320.77
53_L59_E0.5310.76
250_K271_I0.5310.76
101_I105_L0.5300.76
28_L121_V0.5290.76
133_L175_C0.5290.76
248_T251_P0.5280.76
190_V287_L0.5280.76
5_I22_A0.5280.76
104_F111_L0.5270.76
213_M218_F0.5260.76
6_F31_Q0.5240.75
71_V174_A0.5240.75
216_A219_S0.5230.75
200_Y204_L0.5230.75
51_Q91_F0.5210.75
35_T64_Q0.5210.75
221_Y233_H0.5160.74
201_L219_S0.5150.74
196_L230_L0.5150.74
140_K180_G0.5130.74
131_L135_Q0.5120.74
106_A109_D0.5110.74
69_P72_R0.5090.73
23_I58_A0.5080.73
199_D202_S0.5070.73
30_L60_I0.5060.73
15_D18_A0.5060.73
130_A175_C0.5050.73
141_P145_R0.5050.73
23_I26_P0.5050.73
217_L221_Y0.5050.73
4_P116_E0.5030.72
39_N149_M0.5030.72
81_H86_M0.5030.72
81_H88_G0.5010.72
174_A261_E0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wr2A 4 0.9671 100 0.059 Contact Map
1q8fA 4 0.9967 100 0.064 Contact Map
2masA 3 0.9967 100 0.074 Contact Map
3t8jA 3 0.9901 100 0.08 Contact Map
4kpoA 2 0.9934 100 0.081 Contact Map
4kpnA 2 0.9934 100 0.083 Contact Map
3t8iA 3 0.9803 100 0.103 Contact Map
3fz0A 3 0.9934 100 0.104 Contact Map
4i71A 2 0.9605 100 0.133 Contact Map
2c40A 2 0.9309 100 0.134 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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