GREMLIN Database
MUKB - Chromosome partition protein MukB
UniProt: P22523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10618
Length: 1486 (1467)
Sequences: 108 (48)
Seq/√Len: 1.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
1045_I1452_V3.7050.32
12_L1214_Q3.6110.31
1128_G1265_V3.5010.30
12_L187_R3.4780.29
531_E820_R3.4630.29
344_L653_K3.3530.28
990_R1214_Q3.2450.26
12_L69_T3.1340.25
123_I975_S3.0650.24
12_L1038_L3.0300.24
46_A168_F3.0150.23
1131_R1134_H2.9380.23
12_L950_Q2.8630.22
679_E1035_L2.8260.21
55_L1316_Y2.7780.21
397_S529_L2.7600.21
511_L908_A2.6960.20
142_E361_Q2.6860.20
1265_V1379_V2.6060.19
286_D1452_V2.6020.19
1184_I1265_V2.5970.19
357_L1210_E2.5820.19
34_G37_G2.5610.19
34_G39_G2.5610.19
34_G40_K2.5610.19
36_N39_G2.5610.19
36_N40_K2.5610.19
37_G40_K2.5610.19
518_L1080_K2.5200.18
1265_V1431_I2.5010.18
793_E941_E2.4990.18
608_Q1316_Y2.4870.18
187_R1214_Q2.4460.17
592_S1073_S2.4450.17
408_V1452_V2.4400.17
873_V1465_R2.4230.17
101_V155_D2.4200.17
136_V908_A2.4100.17
1045_I1354_S2.3780.17
329_D1324_D2.3730.17
193_D220_Y2.3610.17
427_K1204_R2.3580.17
1244_I1345_E2.3410.16
499_R1141_L2.2890.16
141_N153_L2.2660.16
187_R847_E2.2640.16
25_L224_E2.2520.16
1264_N1431_I2.2490.16
34_G174_Y2.2420.16
36_N174_Y2.2420.16
37_G174_Y2.2420.16
39_G174_Y2.2420.16
40_K174_Y2.2420.16
502_L1348_V2.2350.16
975_S1045_I2.2150.15
438_D571_D2.2140.15
681_F982_N2.2080.15
184_I979_L2.2050.15
1348_V1376_S2.1800.15
1222_L1340_Y2.1740.15
975_S1354_S2.1690.15
436_T919_L2.1670.15
53_P104_V2.1660.15
539_L574_S2.1620.15
48_V1312_L2.1500.15
950_Q1038_L2.1270.15
1124_V1265_V2.1260.15
153_L667_G2.1230.15
804_L990_R2.1230.15
1038_L1214_Q2.1200.15
388_A597_L2.1190.15
1040_R1456_T2.1170.15
309_H1238_R2.1150.15
56_T679_E2.1140.15
68_A693_V2.1020.14
69_T187_R2.0840.14
1034_L1329_T2.0650.14
1319_L1394_G2.0610.14
48_V693_V2.0500.14
12_L1375_M2.0440.14
790_L1422_L2.0320.14
767_W1265_V2.0240.14
81_L182_G2.0140.14
142_E357_L2.0100.14
859_N1265_V2.0090.14
285_L1354_S2.0080.14
514_Q901_R2.0040.14
369_E635_L1.9980.14
187_R990_R1.9880.14
937_E1348_V1.9870.14
226_S759_V1.9710.13
76_G204_S1.9670.13
215_R1442_K1.9500.13
46_A997_E1.9470.13
168_F693_V1.9380.13
148_L847_E1.9280.13
950_Q1375_M1.9200.13
1348_V1382_V1.9170.13
60_F147_V1.9160.13
512_A905_A1.9120.13
1214_Q1316_Y1.9100.13
1374_G1385_W1.9090.13
12_L990_R1.9070.13
1054_E1058_R1.8750.13
356_D1257_M1.8640.13
1153_A1455_N1.8610.13
1170_V1312_L1.8590.13
1287_L1411_L1.8580.13
372_A1170_V1.8570.13
720_V1382_V1.8460.13
908_A1204_R1.8440.13
136_V975_S1.8410.12
783_R1268_G1.8390.12
783_R1365_L1.8390.12
783_R1366_S1.8390.12
783_R1368_G1.8390.12
783_R1369_E1.8390.12
783_R1406_D1.8390.12
783_R1407_E1.8390.12
783_R1435_P1.8390.12
1268_G1365_L1.8390.12
1268_G1366_S1.8390.12
1268_G1368_G1.8390.12
1268_G1369_E1.8390.12
1268_G1406_D1.8390.12
1268_G1407_E1.8390.12
1268_G1435_P1.8390.12
1365_L1368_G1.8390.12
1365_L1369_E1.8390.12
1365_L1406_D1.8390.12
1365_L1407_E1.8390.12
1365_L1435_P1.8390.12
1366_S1369_E1.8390.12
1366_S1406_D1.8390.12
1366_S1407_E1.8390.12
1366_S1435_P1.8390.12
1368_G1406_D1.8390.12
1368_G1407_E1.8390.12
1368_G1435_P1.8390.12
1369_E1406_D1.8390.12
1369_E1407_E1.8390.12
1369_E1435_P1.8390.12
1406_D1435_P1.8390.12
1407_E1435_P1.8390.12
254_S512_A1.8340.12
187_R992_R1.8240.12
332_A544_K1.8240.12
12_L55_L1.8200.12
521_R1303_S1.8200.12
271_A630_E1.8180.12
663_L1267_F1.7990.12
663_L1334_G1.7990.12
663_L1338_L1.7990.12
663_L1352_R1.7990.12
663_L1410_R1.7990.12
663_L1429_Q1.7990.12
1267_F1334_G1.7990.12
1267_F1338_L1.7990.12
1267_F1352_R1.7990.12
1267_F1410_R1.7990.12
1267_F1429_Q1.7990.12
1334_G1338_L1.7990.12
1334_G1352_R1.7990.12
1334_G1410_R1.7990.12
1334_G1429_Q1.7990.12
1338_L1352_R1.7990.12
1338_L1410_R1.7990.12
1338_L1429_Q1.7990.12
1352_R1410_R1.7990.12
1352_R1429_Q1.7990.12
1410_R1429_Q1.7990.12
1244_I1265_V1.7970.12
335_D746_D1.7960.12
13_I1376_S1.7760.12
259_F1270_V1.7740.12
442_E953_A1.7710.12
12_L68_A1.7640.12
1238_R1431_I1.7620.12
8_R462_E1.7600.12
577_R909_A1.7570.12
48_V900_E1.7540.12
990_R1029_D1.7530.12
761_K971_S1.7420.12
207_G217_L1.7380.12
635_L1045_I1.7350.12
698_A782_A1.7280.12
779_G1226_L1.7250.12
779_G1339_D1.7250.12
779_G1367_T1.7250.12
1226_L1339_D1.7250.12
1226_L1367_T1.7250.12
1339_D1367_T1.7250.12
1281_E1452_V1.7190.12
12_L992_R1.7170.12
646_R1394_G1.7160.12
464_K1453_F1.7150.12
183_I927_S1.7140.12
153_L759_V1.7100.12
1282_T1354_S1.7030.12
560_Q1284_A1.7020.12
12_L1101_R1.7010.12
1257_M1414_R1.7010.12
899_R1165_E1.6840.11
1322_Q1379_V1.6810.11
1194_L1404_F1.6780.11
663_L706_G1.6750.11
706_G1267_F1.6750.11
706_G1334_G1.6750.11
706_G1338_L1.6750.11
706_G1352_R1.6750.11
706_G1410_R1.6750.11
706_G1429_Q1.6750.11
134_Q158_E1.6700.11
395_L996_A1.6670.11
147_V1240_V1.6620.11
87_Y235_M1.6610.11
431_H1431_I1.6610.11
44_M76_G1.6560.11
44_M204_S1.6560.11
984_D1124_V1.6530.11
396_K997_E1.6510.11
254_S986_N1.6470.11
844_R1265_V1.6440.11
469_Q736_L1.6430.11
272_A1452_V1.6390.11
123_I1324_D1.6270.11
394_E1034_L1.6260.11
1433_A1448_L1.6150.11
12_L963_V1.6110.11
168_F521_R1.6100.11
702_S1212_I1.6090.11
4_R147_V1.6070.11
92_T1244_I1.6020.11
271_A1141_L1.6020.11
302_L571_D1.5990.11
314_R1100_E1.5910.11
1285_M1469_P1.5820.11
187_R963_V1.5780.11
1038_L1316_Y1.5770.11
863_R1027_S1.5760.11
32_L36_N1.5740.11
32_L37_G1.5740.11
32_L39_G1.5740.11
32_L40_K1.5740.11
51_L1068_L1.5720.11
30_T60_F1.5720.11
1194_L1419_L1.5690.11
346_Q689_I1.5680.11
69_T992_R1.5660.11
354_E695_L1.5640.11
624_S982_N1.5640.11
736_L1465_R1.5640.11
1045_I1282_T1.5570.11
1219_L1419_L1.5550.11
299_R427_K1.5540.11
155_D1003_A1.5520.11
663_L703_A1.5450.11
703_A1267_F1.5450.11
703_A1334_G1.5450.11
703_A1338_L1.5450.11
703_A1352_R1.5450.11
703_A1410_R1.5450.11
703_A1429_Q1.5450.11
185_A207_G1.5410.11
904_E953_A1.5390.10
272_A672_Q1.5350.10
309_H1265_V1.5350.10
1178_K1265_V1.5310.10
706_G776_P1.5270.10
684_V1200_Q1.5230.10
1128_G1264_N1.5210.10
489_L879_I1.5190.10
521_R951_R1.5170.10
426_A668_G1.5120.10
318_E977_E1.5110.10
436_T590_L1.5110.10
358_D458_M1.5080.10
433_P1033_E1.5080.10
804_L1214_Q1.5070.10
60_F1190_V1.5060.10
519_R590_L1.5060.10
1287_L1300_L1.5040.10
1300_L1411_L1.5040.10
185_A1258_L1.5010.10
663_L1343_Y1.4990.10
1267_F1343_Y1.4990.10
1334_G1343_Y1.4990.10
1338_L1343_Y1.4990.10
1343_Y1352_R1.4990.10
1343_Y1410_R1.4990.10
1343_Y1429_Q1.4990.10
44_M235_M1.4980.10
171_I191_A1.4980.10
521_R638_R1.4920.10
331_Q335_D1.4900.10
41_S80_K1.4870.10
751_V911_F1.4860.10
449_A488_P1.4840.10
433_P516_Q1.4820.10
316_L1022_A1.4780.10
1002_R1354_S1.4780.10
442_E1002_R1.4720.10
1282_T1452_V1.4700.10
1301_F1434_A1.4700.10
71_G879_I1.4680.10
32_L221_L1.4650.10
1128_G1379_V1.4650.10
571_D975_S1.4630.10
157_L475_F1.4610.10
368_N1312_L1.4610.10
12_L447_F1.4600.10
1214_Q1375_M1.4590.10
500_E941_E1.4580.10
215_R230_K1.4570.10
931_S1124_V1.4570.10
1177_P1265_V1.4560.10
266_A312_M1.4490.10
306_Q827_A1.4470.10
873_V1469_P1.4470.10
627_D1125_K1.4450.10
768_R1337_L1.4450.10
8_R25_L1.4430.10
868_Q1039_Q1.4430.10
521_R898_I1.4410.10
941_E1055_E1.4390.10
34_G783_R1.4340.10
34_G1268_G1.4340.10
34_G1365_L1.4340.10
34_G1366_S1.4340.10
34_G1368_G1.4340.10
34_G1369_E1.4340.10
34_G1406_D1.4340.10
34_G1407_E1.4340.10
34_G1435_P1.4340.10
36_N783_R1.4340.10
36_N1268_G1.4340.10
36_N1365_L1.4340.10
36_N1366_S1.4340.10
36_N1368_G1.4340.10
36_N1369_E1.4340.10
36_N1406_D1.4340.10
36_N1407_E1.4340.10
36_N1435_P1.4340.10
37_G783_R1.4340.10
37_G1268_G1.4340.10
37_G1365_L1.4340.10
37_G1366_S1.4340.10
37_G1368_G1.4340.10
37_G1369_E1.4340.10
37_G1406_D1.4340.10
37_G1407_E1.4340.10
37_G1435_P1.4340.10
39_G783_R1.4340.10
39_G1268_G1.4340.10
39_G1365_L1.4340.10
39_G1366_S1.4340.10
39_G1368_G1.4340.10
39_G1369_E1.4340.10
39_G1406_D1.4340.10
39_G1407_E1.4340.10
39_G1435_P1.4340.10
40_K783_R1.4340.10
40_K1268_G1.4340.10
40_K1365_L1.4340.10
40_K1366_S1.4340.10
40_K1368_G1.4340.10
40_K1369_E1.4340.10
40_K1406_D1.4340.10
40_K1407_E1.4340.10
40_K1435_P1.4340.10
624_S1027_S1.4330.10
521_R1106_M1.4310.10
1194_L1219_L1.4290.10
425_R1322_Q1.4260.10
478_A1376_S1.4260.10
309_H844_R1.4190.10
1220_S1453_F1.4190.10
54_D604_W1.4180.10
369_E629_T1.4180.10
822_I878_R1.4180.10
499_R1382_V1.4160.10
703_A706_G1.4160.10
82_K143_R1.4120.10
489_L957_A1.4110.10
542_F1316_Y1.4100.10
51_L178_M1.4060.10
1262_L1341_R1.4050.10
62_N210_S1.4010.10
518_L640_R1.4010.10
76_G235_M1.3960.10
204_S235_M1.3960.10
251_V527_Q1.3960.10
180_D1312_L1.3940.10
663_L768_R1.3940.10
663_L1337_L1.3940.10
768_R1267_F1.3940.10
768_R1334_G1.3940.10
768_R1338_L1.3940.10
768_R1352_R1.3940.10
768_R1410_R1.3940.10
768_R1429_Q1.3940.10
982_N1124_V1.3940.10
1267_F1337_L1.3940.10
1334_G1337_L1.3940.10
1337_L1352_R1.3940.10
1337_L1410_R1.3940.10
1337_L1429_Q1.3940.10
12_L180_D1.3920.10
123_I162_G1.3920.10
381_N1431_I1.3920.10
827_A1332_T1.3910.10
1418_T1443_G1.3900.10
271_A937_E1.3900.10
91_D747_S1.3880.10
500_E937_E1.3870.10
658_E793_E1.3870.10
239_L1194_L1.3860.10
134_Q441_A1.3860.10
1010_H1431_I1.3820.10
881_P912_V1.3790.10
898_I1106_M1.3770.10
847_E899_R1.3750.10
187_R1375_M1.3730.10
1322_Q1431_I1.3720.10
86_C205_L1.3710.10
706_G1343_Y1.3700.10
15_W60_F1.3690.09
103_G1394_G1.3690.09
239_L1419_L1.3690.09
649_V962_E1.3670.09
1028_Y1431_I1.3670.09
46_A1124_V1.3630.09
186_R873_V1.3610.09
1067_Q1322_Q1.3600.09
319_H804_L1.3590.09
185_A217_L1.3570.09
539_L1316_Y1.3560.09
76_G1405_L1.3550.09
204_S1405_L1.3550.09
239_L1449_V1.3540.09
12_L71_G1.3530.09
440_A964_V1.3470.09
912_V1469_P1.3450.09
624_S795_E1.3440.09
482_V888_D1.3410.09
32_L779_G1.3400.09
32_L1226_L1.3400.09
32_L1339_D1.3400.09
32_L1367_T1.3400.09
103_G905_A1.3390.09
575_N695_L1.3350.09
168_F734_L1.3280.09
701_F746_D1.3260.09
1413_A1417_A1.3260.09
147_V1190_V1.3260.09
715_P1394_G1.3240.09
1038_L1375_M1.3200.09
181_L992_R1.3190.09
182_G1448_L1.3170.09
596_S599_Q1.3170.09
74_D1403_L1.3150.09
27_E143_R1.3130.09
149_P587_Q1.3120.09
51_L532_Q1.3000.09
13_I168_F1.2990.09
396_K1276_N1.2990.09
360_L760_V1.2980.09
30_T58_L1.2910.09
134_Q1316_Y1.2900.09
598_M759_V1.2900.09
335_D701_F1.2890.09
244_M1427_Q1.2890.09
13_I122_A1.2860.09
651_A952_D1.2850.09
706_G768_R1.2850.09
706_G1337_L1.2850.09
1289_V1296_Q1.2850.09
1456_T1465_R1.2850.09
60_F685_L1.2840.09
302_L500_E1.2830.09
323_E1068_L1.2830.09
224_E463_Q1.2810.09
693_V1312_L1.2810.09
81_L1433_A1.2810.09
432_L823_G1.2770.09
486_N973_S1.2760.09
69_T1034_L1.2750.09
217_L221_L1.2750.09
679_E1316_Y1.2750.09
878_R978_M1.2740.09
981_G1210_E1.2740.09
187_R905_A1.2730.09
325_D800_R1.2720.09
70_S103_G1.2710.09
956_Q1127_N1.2670.09
383_A696_E1.2670.09
990_R1038_L1.2650.09
468_A838_I1.2580.09
876_L1449_V1.2580.09
44_M87_Y1.2570.09
905_A1394_G1.2540.09
732_E792_A1.2500.09
1038_L1101_R1.2500.09
319_H962_E1.2500.09
755_E1043_Q1.2480.09
32_L174_Y1.2480.09
394_E992_R1.2460.09
74_D221_L1.2440.09
581_M1128_G1.2410.09
13_I390_L1.2400.09
136_V511_L1.2400.09
899_R1329_T1.2380.09
380_E953_A1.2370.09
69_T394_E1.2320.09
761_K767_W1.2320.09
413_A1381_V1.2310.09
1232_K1316_Y1.2300.09
13_I580_R1.2290.09
13_I795_E1.2290.09
226_S592_S1.2280.09
137_T158_E1.2270.09
323_E1075_R1.2260.09
681_F791_H1.2260.09
70_S308_K1.2260.09
168_F199_R1.2240.09
1371_I1374_G1.2240.09
285_L1452_V1.2220.09
433_P1044_D1.2210.09
187_R950_Q1.2200.09
2_I718_S1.2200.09
153_L229_R1.2180.09
357_L622_F1.2180.09
1124_V1431_I1.2170.09
8_R537_R1.2160.09
239_L1219_L1.2160.09
683_G731_P1.2160.09
661_E1182_R1.2150.09
143_R570_S1.2140.09
7_F25_L1.2130.09
85_V963_V1.2130.09
81_L1448_L1.2120.09
461_L1135_R1.2100.09
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696_E1104_F0.5020.06
1010_H1075_R0.5020.06
155_D533_Q0.5010.06
574_S1153_A0.5010.06
235_M1374_G0.5010.06
971_S1220_S0.5010.06
1222_L1404_F0.5000.06
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ibpA 2 0.1904 100 0.825 Contact Map
3eujA 2 0.2941 100 0.884 Contact Map
2wmmA 2 0.109 100 0.886 Contact Map
1qhlA 1 0.1366 100 0.929 Contact Map
4rsiA 1 0.1487 98.9 0.978 Contact Map
4rsiB 1 0.2227 98.9 0.979 Contact Map
3qksA 1 0.1299 98.8 0.98 Contact Map
1f2tA 1 0.0956 98.5 0.981 Contact Map
4ux3A 1 0.2598 98.4 0.982 Contact Map
4hseA 1 0.2234 98.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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