ADD - ECOLI - GREMLIN Contacts

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ADD - Adenosine deaminase

UniProt:	P22333	Sequences: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVREGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10030
Length:	333 (318)
Sequences:	4069 (2646)
Seq/√Len:	148.4

ECOLI - ADD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_H	217_E	4.702	1.00
234_F	238_Q	4.432	1.00
77_R	125_E	4.162	1.00
301_S	304_Q	3.451	1.00
224_K	227_E	3.180	1.00
81_F	129_T	3.148	1.00
178_S	209_Q	2.994	1.00
77_R	121_D	2.951	1.00
225_A	235_L	2.618	1.00
314_E	327_R	2.594	1.00
113_A	158_A	2.472	1.00
233_D	237_E	2.447	1.00
80_A	119_V	2.379	1.00
275_I	294_A	2.302	1.00
318_L	322_E	2.224	1.00
264_K	304_Q	2.195	1.00
309_Q	312_G	2.180	1.00
319_S	322_E	2.141	1.00
291_Y	309_Q	2.136	1.00
9_T	312_G	2.122	1.00
257_E	260_A	2.108	1.00
207_I	225_A	2.075	1.00
310_I	327_R	2.047	1.00
9_T	313_L	1.997	1.00
264_K	268_E	1.962	1.00
81_F	125_E	1.947	1.00
87_A	95_V	1.911	1.00
127_C	133_Q	1.903	1.00
239_Q	272_R	1.891	1.00
59_F	279_D	1.879	1.00
85_E	129_T	1.873	1.00
241_G	315_M	1.845	1.00
81_F	130_F	1.837	1.00
154_E	186_R	1.829	1.00
20_R	86_D	1.823	1.00
146_E	182_S	1.813	1.00
92_L	287_I	1.781	1.00
30_Q	78_R	1.778	1.00
313_L	326_L	1.775	1.00
205_E	209_Q	1.703	1.00
219_I	222_G	1.690	1.00
285_V	289_H	1.687	1.00
20_R	82_E	1.665	1.00
150_Q	186_R	1.634	1.00
230_A	233_D	1.627	1.00
241_G	274_S	1.626	1.00
111_P	114_G	1.624	1.00
186_R	189_D	1.611	1.00
236_A	271_I	1.602	1.00
123_V	134_A	1.600	1.00
94_Y	133_Q	1.595	1.00
157_L	160_R	1.593	1.00
188_R	194_I	1.586	1.00
256_A	260_A	1.585	1.00
156_F	192_W	1.570	1.00
268_E	304_Q	1.562	1.00
267_L	300_L	1.554	1.00
73_L	114_G	1.548	1.00
84_I	134_A	1.544	1.00
220_G	243_E	1.539	1.00
125_E	129_T	1.538	1.00
137_I	165_A	1.537	1.00
292_T	296_P	1.514	1.00
247_T	290_E	1.512	1.00
26_E	78_R	1.511	1.00
186_R	190_A	1.502	1.00
55_D	58_S	1.499	1.00
211_I	234_F	1.489	1.00
77_R	122_G	1.486	1.00
209_Q	213_E	1.473	1.00
38_Q	42_T	1.472	1.00
272_R	314_E	1.470	1.00
322_E	325_A	1.464	1.00
181_L	185_N	1.457	1.00
211_I	240_I	1.452	1.00
263_L	294_A	1.443	1.00
208_W	234_F	1.441	1.00
306_R	310_I	1.435	1.00
67_V	103_Y	1.404	1.00
145_G	148_A	1.402	1.00
120_I	124_R	1.402	1.00
153_L	183_H	1.390	1.00
279_D	283_Q	1.387	1.00
208_W	231_L	1.382	1.00
31_Y	72_S	1.379	1.00
313_L	327_R	1.375	1.00
287_I	291_Y	1.367	1.00
91_G	288_I	1.363	1.00
272_R	315_M	1.362	1.00
140_M	166_L	1.360	1.00
117_E	159_H	1.355	1.00
98_R	167_D	1.354	1.00
266_F	271_I	1.351	1.00
320_A	324_R	1.344	1.00
73_L	121_D	1.343	1.00
157_L	190_A	1.342	1.00
295_A	302_R	1.341	1.00
175_F	179_L	1.340	1.00
316_A	323_K	1.336	1.00
258_L	293_V	1.327	1.00
149_C	183_H	1.311	1.00
15_L	97_L	1.310	1.00
234_F	237_E	1.310	1.00
154_E	158_A	1.291	1.00
300_L	308_A	1.284	1.00
313_L	323_K	1.277	1.00
81_F	85_E	1.275	1.00
233_D	269_H	1.259	1.00
310_I	314_E	1.250	1.00
84_I	123_V	1.248	1.00
226_I	266_F	1.248	1.00
143_T	171_D	1.243	1.00
241_G	272_R	1.227	1.00
150_Q	154_E	1.226	1.00
31_Y	75_A	1.223	1.00
274_S	315_M	1.216	1.00
157_L	186_R	1.214	1.00
138_G	156_F	1.213	1.00
82_E	86_D	1.212	1.00
289_H	293_V	1.201	1.00
78_R	82_E	1.193	1.00
80_A	84_I	1.190	1.00
98_R	165_A	1.187	1.00
198_A	210_A	1.184	1.00
113_A	159_H	1.180	1.00
223_V	255_V	1.180	1.00
39_S	42_T	1.172	1.00
13_R	18_N	1.167	1.00
264_K	300_L	1.165	1.00
208_W	230_A	1.164	1.00
223_V	254_T	1.154	1.00
188_R	215_G	1.153	1.00
124_R	128_R	1.146	1.00
90_H	288_I	1.140	1.00
20_R	23_T	1.120	0.99
151_Q	155_A	1.118	0.99
113_A	117_E	1.117	0.99
322_E	326_L	1.109	0.99
135_K	164_T	1.105	0.99
318_L	326_L	1.103	0.99
19_I	79_V	1.103	0.99
185_N	189_D	1.100	0.99
307_Q	314_E	1.097	0.99
153_L	157_L	1.090	0.99
84_I	126_G	1.089	0.99
295_A	305_I	1.085	0.99
94_Y	135_K	1.082	0.99
247_T	293_V	1.080	0.99
208_W	228_D	1.070	0.99
265_T	268_E	1.067	0.99
114_G	117_E	1.066	0.99
263_L	298_A	1.065	0.99
153_L	186_R	1.053	0.99
83_N	97_L	1.047	0.99
124_R	127_C	1.040	0.99
23_T	27_L	1.024	0.99
81_F	122_G	1.024	0.99
324_R	328_E	1.021	0.99
235_L	242_I	1.019	0.99
226_I	265_T	1.015	0.99
250_I	258_L	1.014	0.99
195_T	317_F	1.008	0.99
12_H	197_H	1.007	0.99
233_D	236_A	1.001	0.99
124_R	162_Q	1.001	0.99
117_E	121_D	0.999	0.99
74_D	78_R	0.997	0.99
160_R	190_A	0.993	0.99
229_R	233_D	0.988	0.99
138_G	163_I	0.986	0.99
294_A	300_L	0.980	0.99
264_K	298_A	0.979	0.99
26_E	82_E	0.978	0.98
300_L	304_Q	0.976	0.98
229_R	269_H	0.976	0.98
56_L	60_L	0.973	0.98
22_Q	26_E	0.969	0.98
286_D	289_H	0.969	0.98
181_L	213_E	0.969	0.98
20_R	85_E	0.968	0.98
244_S	266_F	0.967	0.98
184_F	194_I	0.966	0.98
154_E	157_L	0.959	0.98
211_I	235_L	0.959	0.98
232_M	269_H	0.955	0.98
307_Q	311_N	0.952	0.98
226_I	232_M	0.949	0.98
139_I	169_A	0.948	0.98
142_R	168_L	0.938	0.98
77_R	81_F	0.934	0.98
204_P	231_L	0.933	0.98
187_A	191_G	0.931	0.98
12_H	278_D	0.930	0.98
73_L	110_L	0.923	0.98
123_V	126_G	0.922	0.98
88_A	132_V	0.920	0.98
166_L	184_F	0.919	0.98
122_G	125_E	0.917	0.98
263_L	267_L	0.917	0.98
70_L	79_V	0.915	0.98
14_H	278_D	0.913	0.98
197_H	278_D	0.904	0.97
133_Q	322_E	0.903	0.97
99_F	115_V	0.902	0.97
197_H	200_E	0.902	0.97
223_V	249_N	0.902	0.97
118_A	122_G	0.901	0.97
307_Q	310_I	0.901	0.97
135_K	322_E	0.899	0.97
57_V	171_D	0.894	0.97
182_S	185_N	0.889	0.97
54_P	58_S	0.887	0.97
138_G	152_E	0.885	0.97
244_S	261_H	0.884	0.97
196_V	216_A	0.878	0.97
239_Q	314_E	0.876	0.97
20_R	78_R	0.876	0.97
122_G	126_G	0.875	0.97
320_A	327_R	0.874	0.97
30_Q	74_D	0.871	0.97
144_F	171_D	0.871	0.97
95_V	134_A	0.867	0.97
275_I	291_Y	0.867	0.97
150_Q	182_S	0.866	0.97
236_A	269_H	0.864	0.97
267_L	304_Q	0.862	0.97
85_E	130_F	0.860	0.97
14_H	197_H	0.857	0.97
135_K	319_S	0.856	0.97
272_R	311_N	0.855	0.96
225_A	232_M	0.855	0.96
98_R	139_I	0.853	0.96
305_I	309_Q	0.853	0.96
291_Y	295_A	0.852	0.96
120_I	162_Q	0.848	0.96
211_I	238_Q	0.847	0.96
180_F	183_H	0.846	0.96
265_T	269_H	0.845	0.96
18_N	83_N	0.842	0.96
255_V	262_P	0.841	0.96
246_L	294_A	0.836	0.96
285_V	290_E	0.826	0.96
232_M	271_I	0.818	0.95
86_D	89_R	0.816	0.95
147_A	151_Q	0.815	0.95
144_F	148_A	0.814	0.95
126_G	131_G	0.813	0.95
23_T	82_E	0.812	0.95
187_A	192_W	0.812	0.95
171_D	174_G	0.806	0.95
65_W	68_K	0.802	0.95
324_R	327_R	0.802	0.95
185_N	188_R	0.799	0.95
197_H	221_H	0.791	0.95
200_E	278_D	0.788	0.94
204_P	227_E	0.785	0.94
14_H	221_H	0.778	0.94
25_L	29_R	0.778	0.94
68_K	71_A	0.776	0.94
153_L	190_A	0.776	0.94
80_A	122_G	0.772	0.94
289_H	292_T	0.772	0.94
100_S	141_S	0.770	0.94
313_L	318_L	0.768	0.94
207_I	231_L	0.768	0.94
146_E	179_L	0.766	0.94
13_R	280_P	0.765	0.94
200_E	249_N	0.765	0.94
188_R	217_E	0.761	0.93
150_Q	183_H	0.761	0.93
57_V	61_T	0.760	0.93
85_E	89_R	0.759	0.93
308_A	312_G	0.756	0.93
140_M	149_C	0.755	0.93
116_V	138_G	0.751	0.93
73_L	117_E	0.750	0.93
61_T	64_D	0.749	0.93
205_E	208_W	0.749	0.93
194_I	215_G	0.747	0.93
9_T	309_Q	0.746	0.93
168_L	196_V	0.746	0.93
199_G	207_I	0.744	0.93
99_F	136_L	0.741	0.92
201_A	224_K	0.740	0.92
318_L	323_K	0.740	0.92
59_F	283_Q	0.735	0.92
267_L	307_Q	0.729	0.92
30_Q	75_A	0.728	0.92
93_H	326_L	0.728	0.92
263_L	300_L	0.728	0.92
223_V	244_S	0.727	0.92
73_L	77_R	0.726	0.92
82_E	85_E	0.725	0.92
247_T	285_V	0.723	0.92
137_I	195_T	0.721	0.91
10_D	287_I	0.717	0.91
277_T	290_E	0.717	0.91
250_I	255_V	0.712	0.91
19_I	66_G	0.710	0.91
291_Y	312_G	0.709	0.91
107_A	148_A	0.707	0.91
204_P	228_D	0.706	0.91
194_I	216_A	0.704	0.90
294_A	298_A	0.703	0.90
275_I	308_A	0.698	0.90
267_L	311_N	0.697	0.90
12_H	221_H	0.697	0.90
311_N	315_M	0.697	0.90
123_V	136_L	0.697	0.90
56_L	252_T	0.696	0.90
119_V	136_L	0.694	0.90
148_A	151_Q	0.693	0.90
194_I	217_E	0.692	0.90
4_T	288_I	0.691	0.90
246_L	275_I	0.688	0.89
288_I	292_T	0.687	0.89
321_E	325_A	0.686	0.89
10_D	277_T	0.685	0.89
304_Q	307_Q	0.683	0.89
294_A	297_A	0.683	0.89
267_L	273_A	0.681	0.89
126_G	130_F	0.681	0.89
202_A	206_S	0.681	0.89
100_S	139_I	0.680	0.89
200_E	221_H	0.679	0.89
90_H	280_P	0.678	0.89
151_Q	154_E	0.673	0.88
24_I	66_G	0.672	0.88
98_R	243_E	0.670	0.88
76_C	118_A	0.668	0.88
12_H	200_E	0.668	0.88
183_H	186_R	0.668	0.88
150_Q	153_L	0.664	0.88
24_I	43_L	0.663	0.88
121_D	125_E	0.663	0.88
273_A	308_A	0.659	0.87
26_E	29_R	0.659	0.87
210_A	216_A	0.657	0.87
200_E	248_S	0.657	0.87
42_T	45_P	0.656	0.87
146_E	150_Q	0.656	0.87
177_G	210_A	0.655	0.87
71_A	110_L	0.654	0.87
221_H	278_D	0.653	0.87
94_Y	316_A	0.651	0.87
58_S	61_T	0.651	0.87
16_D	76_C	0.647	0.86
221_H	279_D	0.644	0.86
291_Y	305_I	0.644	0.86
17_G	279_D	0.644	0.86
320_A	323_K	0.642	0.86
28_G	35_L	0.642	0.86
198_A	219_I	0.637	0.86
116_V	136_L	0.635	0.85
166_L	187_A	0.633	0.85
222_G	242_I	0.628	0.85
92_L	95_V	0.625	0.84
98_R	220_G	0.624	0.84
182_S	186_R	0.623	0.84
145_G	179_L	0.622	0.84
259_A	297_A	0.620	0.84
219_I	235_L	0.619	0.84
178_S	181_L	0.619	0.84
263_L	273_A	0.618	0.84
100_S	169_A	0.618	0.84
293_V	296_P	0.617	0.84
33_I	36_P	0.615	0.83
160_R	192_W	0.615	0.83
206_S	209_Q	0.614	0.83
149_C	152_E	0.613	0.83
247_T	289_H	0.611	0.83
176_P	179_L	0.609	0.83
270_G	307_Q	0.609	0.83
232_M	266_F	0.605	0.82
23_T	78_R	0.603	0.82
125_E	128_R	0.602	0.82
37_A	42_T	0.601	0.82
274_S	311_N	0.599	0.82
264_K	267_L	0.599	0.82
19_I	27_L	0.596	0.82
152_E	156_F	0.594	0.81
18_N	280_P	0.594	0.81
23_T	86_D	0.593	0.81
314_E	320_A	0.589	0.81
97_L	123_V	0.587	0.81
97_L	136_L	0.587	0.81
74_D	77_R	0.586	0.80
235_L	240_I	0.585	0.80
207_I	222_G	0.584	0.80
110_L	114_G	0.583	0.80
78_R	86_D	0.582	0.80
292_T	302_R	0.582	0.80
241_G	273_A	0.581	0.80
41_E	45_P	0.580	0.80
141_S	169_A	0.576	0.79
72_S	75_A	0.576	0.79
298_A	308_A	0.576	0.79
169_A	220_G	0.575	0.79
185_N	215_G	0.575	0.79
208_W	225_A	0.575	0.79
79_V	82_E	0.575	0.79
165_A	218_R	0.574	0.79
8_L	288_I	0.573	0.79
155_A	159_H	0.573	0.79
184_F	196_V	0.573	0.79
224_K	242_I	0.573	0.79
248_S	279_D	0.570	0.79
19_I	24_I	0.570	0.79
199_G	252_T	0.570	0.79
321_E	324_R	0.569	0.78
160_R	163_I	0.567	0.78
112_V	116_V	0.565	0.78
255_V	266_F	0.563	0.78
242_I	266_F	0.561	0.78
264_K	294_A	0.560	0.77
247_T	251_Q	0.560	0.77
303_E	306_R	0.560	0.77
80_A	123_V	0.560	0.77
121_D	124_R	0.560	0.77
163_I	166_L	0.559	0.77
319_S	325_A	0.558	0.77
199_G	202_A	0.554	0.77
251_Q	283_Q	0.549	0.76
128_R	324_R	0.546	0.76
293_V	297_A	0.546	0.76
149_C	169_A	0.546	0.76
263_L	275_I	0.542	0.75
194_I	214_L	0.541	0.75
241_G	311_N	0.540	0.75
13_R	95_V	0.539	0.75
4_T	292_T	0.539	0.75
22_Q	40_L	0.538	0.75
248_S	278_D	0.537	0.74
166_L	194_I	0.537	0.74
112_V	152_E	0.537	0.74
225_A	242_I	0.536	0.74
267_L	308_A	0.536	0.74
300_L	305_I	0.536	0.74
21_P	28_G	0.535	0.74
127_C	135_K	0.534	0.74
31_Y	78_R	0.533	0.74
88_A	126_G	0.530	0.73
199_G	262_P	0.528	0.73
312_G	326_L	0.527	0.73
211_I	219_I	0.527	0.73
215_G	238_Q	0.526	0.73
84_I	95_V	0.525	0.73
309_Q	313_L	0.524	0.73
12_H	279_D	0.524	0.73
4_T	91_G	0.523	0.72
99_F	102_G	0.522	0.72
201_A	206_S	0.521	0.72
76_C	119_V	0.521	0.72
16_D	70_L	0.519	0.72
218_R	243_E	0.516	0.71
236_A	239_Q	0.516	0.71
223_V	262_P	0.515	0.71
117_E	162_Q	0.515	0.71
13_R	97_L	0.515	0.71
96_E	165_A	0.514	0.71
235_L	271_I	0.512	0.71
12_H	248_S	0.512	0.71
59_F	172_E	0.511	0.71
284_G	289_H	0.511	0.71
294_A	305_I	0.510	0.71
277_T	287_I	0.509	0.70
199_G	249_N	0.508	0.70
204_P	207_I	0.507	0.70
236_A	270_G	0.507	0.70
32_N	35_L	0.506	0.70
112_V	115_V	0.504	0.70
68_K	107_A	0.503	0.70
274_S	308_A	0.501	0.69
248_S	283_Q	0.501	0.69
203_G	206_S	0.500	0.69
172_E	206_S	0.500	0.69
203_G	224_K	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3iarA	1	0.988	100	0.274	Contact Map
2pgfA	1	0.985	100	0.278	Contact Map
3rysA	1	0.985	100	0.284	Contact Map
3lgdA	2	0.997	100	0.295	Contact Map
3paoA	1	0.9399	100	0.327	Contact Map
2a3lA	3	0.961	100	0.336	Contact Map
4gxwA	1	0.976	100	0.369	Contact Map
1p1mA	2	0.8258	99.5	0.818	Contact Map
3lnpA	2	0.8348	99.5	0.823	Contact Map
4r85A	4	0.8829	99.4	0.828	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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