GREMLIN Database
ADD - Adenosine deaminase
UniProt: P22333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10030
Length: 333 (318)
Sequences: 4069 (2646)
Seq/√Len: 148.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_H217_E4.7021.00
234_F238_Q4.4321.00
77_R125_E4.1621.00
301_S304_Q3.4511.00
224_K227_E3.1801.00
81_F129_T3.1481.00
178_S209_Q2.9941.00
77_R121_D2.9511.00
225_A235_L2.6181.00
314_E327_R2.5941.00
113_A158_A2.4721.00
233_D237_E2.4471.00
80_A119_V2.3791.00
275_I294_A2.3021.00
318_L322_E2.2241.00
264_K304_Q2.1951.00
309_Q312_G2.1801.00
319_S322_E2.1411.00
291_Y309_Q2.1361.00
9_T312_G2.1221.00
257_E260_A2.1081.00
207_I225_A2.0751.00
310_I327_R2.0471.00
9_T313_L1.9971.00
264_K268_E1.9621.00
81_F125_E1.9471.00
87_A95_V1.9111.00
127_C133_Q1.9031.00
239_Q272_R1.8911.00
59_F279_D1.8791.00
85_E129_T1.8731.00
241_G315_M1.8451.00
81_F130_F1.8371.00
154_E186_R1.8291.00
20_R86_D1.8231.00
146_E182_S1.8131.00
92_L287_I1.7811.00
30_Q78_R1.7781.00
313_L326_L1.7751.00
205_E209_Q1.7031.00
219_I222_G1.6901.00
285_V289_H1.6871.00
20_R82_E1.6651.00
150_Q186_R1.6341.00
230_A233_D1.6271.00
241_G274_S1.6261.00
111_P114_G1.6241.00
186_R189_D1.6111.00
236_A271_I1.6021.00
123_V134_A1.6001.00
94_Y133_Q1.5951.00
157_L160_R1.5931.00
188_R194_I1.5861.00
256_A260_A1.5851.00
156_F192_W1.5701.00
268_E304_Q1.5621.00
267_L300_L1.5541.00
73_L114_G1.5481.00
84_I134_A1.5441.00
220_G243_E1.5391.00
125_E129_T1.5381.00
137_I165_A1.5371.00
292_T296_P1.5141.00
247_T290_E1.5121.00
26_E78_R1.5111.00
186_R190_A1.5021.00
55_D58_S1.4991.00
211_I234_F1.4891.00
77_R122_G1.4861.00
209_Q213_E1.4731.00
38_Q42_T1.4721.00
272_R314_E1.4701.00
322_E325_A1.4641.00
181_L185_N1.4571.00
211_I240_I1.4521.00
263_L294_A1.4431.00
208_W234_F1.4411.00
306_R310_I1.4351.00
67_V103_Y1.4041.00
145_G148_A1.4021.00
120_I124_R1.4021.00
153_L183_H1.3901.00
279_D283_Q1.3871.00
208_W231_L1.3821.00
31_Y72_S1.3791.00
313_L327_R1.3751.00
287_I291_Y1.3671.00
91_G288_I1.3631.00
272_R315_M1.3621.00
140_M166_L1.3601.00
117_E159_H1.3551.00
98_R167_D1.3541.00
266_F271_I1.3511.00
320_A324_R1.3441.00
73_L121_D1.3431.00
157_L190_A1.3421.00
295_A302_R1.3411.00
175_F179_L1.3401.00
316_A323_K1.3361.00
258_L293_V1.3271.00
149_C183_H1.3111.00
15_L97_L1.3101.00
234_F237_E1.3101.00
154_E158_A1.2911.00
300_L308_A1.2841.00
313_L323_K1.2771.00
81_F85_E1.2751.00
233_D269_H1.2591.00
310_I314_E1.2501.00
84_I123_V1.2481.00
226_I266_F1.2481.00
143_T171_D1.2431.00
241_G272_R1.2271.00
150_Q154_E1.2261.00
31_Y75_A1.2231.00
274_S315_M1.2161.00
157_L186_R1.2141.00
138_G156_F1.2131.00
82_E86_D1.2121.00
289_H293_V1.2011.00
78_R82_E1.1931.00
80_A84_I1.1901.00
98_R165_A1.1871.00
198_A210_A1.1841.00
113_A159_H1.1801.00
223_V255_V1.1801.00
39_S42_T1.1721.00
13_R18_N1.1671.00
264_K300_L1.1651.00
208_W230_A1.1641.00
223_V254_T1.1541.00
188_R215_G1.1531.00
124_R128_R1.1461.00
90_H288_I1.1401.00
20_R23_T1.1200.99
151_Q155_A1.1180.99
113_A117_E1.1170.99
322_E326_L1.1090.99
135_K164_T1.1050.99
318_L326_L1.1030.99
19_I79_V1.1030.99
185_N189_D1.1000.99
307_Q314_E1.0970.99
153_L157_L1.0900.99
84_I126_G1.0890.99
295_A305_I1.0850.99
94_Y135_K1.0820.99
247_T293_V1.0800.99
208_W228_D1.0700.99
265_T268_E1.0670.99
114_G117_E1.0660.99
263_L298_A1.0650.99
153_L186_R1.0530.99
83_N97_L1.0470.99
124_R127_C1.0400.99
23_T27_L1.0240.99
81_F122_G1.0240.99
324_R328_E1.0210.99
235_L242_I1.0190.99
226_I265_T1.0150.99
250_I258_L1.0140.99
195_T317_F1.0080.99
12_H197_H1.0070.99
233_D236_A1.0010.99
124_R162_Q1.0010.99
117_E121_D0.9990.99
74_D78_R0.9970.99
160_R190_A0.9930.99
229_R233_D0.9880.99
138_G163_I0.9860.99
294_A300_L0.9800.99
264_K298_A0.9790.99
26_E82_E0.9780.98
300_L304_Q0.9760.98
229_R269_H0.9760.98
56_L60_L0.9730.98
22_Q26_E0.9690.98
286_D289_H0.9690.98
181_L213_E0.9690.98
20_R85_E0.9680.98
244_S266_F0.9670.98
184_F194_I0.9660.98
154_E157_L0.9590.98
211_I235_L0.9590.98
232_M269_H0.9550.98
307_Q311_N0.9520.98
226_I232_M0.9490.98
139_I169_A0.9480.98
142_R168_L0.9380.98
77_R81_F0.9340.98
204_P231_L0.9330.98
187_A191_G0.9310.98
12_H278_D0.9300.98
73_L110_L0.9230.98
123_V126_G0.9220.98
88_A132_V0.9200.98
166_L184_F0.9190.98
122_G125_E0.9170.98
263_L267_L0.9170.98
70_L79_V0.9150.98
14_H278_D0.9130.98
197_H278_D0.9040.97
133_Q322_E0.9030.97
99_F115_V0.9020.97
197_H200_E0.9020.97
223_V249_N0.9020.97
118_A122_G0.9010.97
307_Q310_I0.9010.97
135_K322_E0.8990.97
57_V171_D0.8940.97
182_S185_N0.8890.97
54_P58_S0.8870.97
138_G152_E0.8850.97
244_S261_H0.8840.97
196_V216_A0.8780.97
239_Q314_E0.8760.97
20_R78_R0.8760.97
122_G126_G0.8750.97
320_A327_R0.8740.97
30_Q74_D0.8710.97
144_F171_D0.8710.97
95_V134_A0.8670.97
275_I291_Y0.8670.97
150_Q182_S0.8660.97
236_A269_H0.8640.97
267_L304_Q0.8620.97
85_E130_F0.8600.97
14_H197_H0.8570.97
135_K319_S0.8560.97
272_R311_N0.8550.96
225_A232_M0.8550.96
98_R139_I0.8530.96
305_I309_Q0.8530.96
291_Y295_A0.8520.96
120_I162_Q0.8480.96
211_I238_Q0.8470.96
180_F183_H0.8460.96
265_T269_H0.8450.96
18_N83_N0.8420.96
255_V262_P0.8410.96
246_L294_A0.8360.96
285_V290_E0.8260.96
232_M271_I0.8180.95
86_D89_R0.8160.95
147_A151_Q0.8150.95
144_F148_A0.8140.95
126_G131_G0.8130.95
23_T82_E0.8120.95
187_A192_W0.8120.95
171_D174_G0.8060.95
65_W68_K0.8020.95
324_R327_R0.8020.95
185_N188_R0.7990.95
197_H221_H0.7910.95
200_E278_D0.7880.94
204_P227_E0.7850.94
14_H221_H0.7780.94
25_L29_R0.7780.94
68_K71_A0.7760.94
153_L190_A0.7760.94
80_A122_G0.7720.94
289_H292_T0.7720.94
100_S141_S0.7700.94
313_L318_L0.7680.94
207_I231_L0.7680.94
146_E179_L0.7660.94
13_R280_P0.7650.94
200_E249_N0.7650.94
188_R217_E0.7610.93
150_Q183_H0.7610.93
57_V61_T0.7600.93
85_E89_R0.7590.93
308_A312_G0.7560.93
140_M149_C0.7550.93
116_V138_G0.7510.93
73_L117_E0.7500.93
61_T64_D0.7490.93
205_E208_W0.7490.93
194_I215_G0.7470.93
9_T309_Q0.7460.93
168_L196_V0.7460.93
199_G207_I0.7440.93
99_F136_L0.7410.92
201_A224_K0.7400.92
318_L323_K0.7400.92
59_F283_Q0.7350.92
267_L307_Q0.7290.92
30_Q75_A0.7280.92
93_H326_L0.7280.92
263_L300_L0.7280.92
223_V244_S0.7270.92
73_L77_R0.7260.92
82_E85_E0.7250.92
247_T285_V0.7230.92
137_I195_T0.7210.91
10_D287_I0.7170.91
277_T290_E0.7170.91
250_I255_V0.7120.91
19_I66_G0.7100.91
291_Y312_G0.7090.91
107_A148_A0.7070.91
204_P228_D0.7060.91
194_I216_A0.7040.90
294_A298_A0.7030.90
275_I308_A0.6980.90
267_L311_N0.6970.90
12_H221_H0.6970.90
311_N315_M0.6970.90
123_V136_L0.6970.90
56_L252_T0.6960.90
119_V136_L0.6940.90
148_A151_Q0.6930.90
194_I217_E0.6920.90
4_T288_I0.6910.90
246_L275_I0.6880.89
288_I292_T0.6870.89
321_E325_A0.6860.89
10_D277_T0.6850.89
304_Q307_Q0.6830.89
294_A297_A0.6830.89
267_L273_A0.6810.89
126_G130_F0.6810.89
202_A206_S0.6810.89
100_S139_I0.6800.89
200_E221_H0.6790.89
90_H280_P0.6780.89
151_Q154_E0.6730.88
24_I66_G0.6720.88
98_R243_E0.6700.88
76_C118_A0.6680.88
12_H200_E0.6680.88
183_H186_R0.6680.88
150_Q153_L0.6640.88
24_I43_L0.6630.88
121_D125_E0.6630.88
273_A308_A0.6590.87
26_E29_R0.6590.87
210_A216_A0.6570.87
200_E248_S0.6570.87
42_T45_P0.6560.87
146_E150_Q0.6560.87
177_G210_A0.6550.87
71_A110_L0.6540.87
221_H278_D0.6530.87
94_Y316_A0.6510.87
58_S61_T0.6510.87
16_D76_C0.6470.86
221_H279_D0.6440.86
291_Y305_I0.6440.86
17_G279_D0.6440.86
320_A323_K0.6420.86
28_G35_L0.6420.86
198_A219_I0.6370.86
116_V136_L0.6350.85
166_L187_A0.6330.85
222_G242_I0.6280.85
92_L95_V0.6250.84
98_R220_G0.6240.84
182_S186_R0.6230.84
145_G179_L0.6220.84
259_A297_A0.6200.84
219_I235_L0.6190.84
178_S181_L0.6190.84
263_L273_A0.6180.84
100_S169_A0.6180.84
293_V296_P0.6170.84
33_I36_P0.6150.83
160_R192_W0.6150.83
206_S209_Q0.6140.83
149_C152_E0.6130.83
247_T289_H0.6110.83
176_P179_L0.6090.83
270_G307_Q0.6090.83
232_M266_F0.6050.82
23_T78_R0.6030.82
125_E128_R0.6020.82
37_A42_T0.6010.82
274_S311_N0.5990.82
264_K267_L0.5990.82
19_I27_L0.5960.82
152_E156_F0.5940.81
18_N280_P0.5940.81
23_T86_D0.5930.81
314_E320_A0.5890.81
97_L123_V0.5870.81
97_L136_L0.5870.81
74_D77_R0.5860.80
235_L240_I0.5850.80
207_I222_G0.5840.80
110_L114_G0.5830.80
78_R86_D0.5820.80
292_T302_R0.5820.80
241_G273_A0.5810.80
41_E45_P0.5800.80
141_S169_A0.5760.79
72_S75_A0.5760.79
298_A308_A0.5760.79
169_A220_G0.5750.79
185_N215_G0.5750.79
208_W225_A0.5750.79
79_V82_E0.5750.79
165_A218_R0.5740.79
8_L288_I0.5730.79
155_A159_H0.5730.79
184_F196_V0.5730.79
224_K242_I0.5730.79
248_S279_D0.5700.79
19_I24_I0.5700.79
199_G252_T0.5700.79
321_E324_R0.5690.78
160_R163_I0.5670.78
112_V116_V0.5650.78
255_V266_F0.5630.78
242_I266_F0.5610.78
264_K294_A0.5600.77
247_T251_Q0.5600.77
303_E306_R0.5600.77
80_A123_V0.5600.77
121_D124_R0.5600.77
163_I166_L0.5590.77
319_S325_A0.5580.77
199_G202_A0.5540.77
251_Q283_Q0.5490.76
128_R324_R0.5460.76
293_V297_A0.5460.76
149_C169_A0.5460.76
263_L275_I0.5420.75
194_I214_L0.5410.75
241_G311_N0.5400.75
13_R95_V0.5390.75
4_T292_T0.5390.75
22_Q40_L0.5380.75
248_S278_D0.5370.74
166_L194_I0.5370.74
112_V152_E0.5370.74
225_A242_I0.5360.74
267_L308_A0.5360.74
300_L305_I0.5360.74
21_P28_G0.5350.74
127_C135_K0.5340.74
31_Y78_R0.5330.74
88_A126_G0.5300.73
199_G262_P0.5280.73
312_G326_L0.5270.73
211_I219_I0.5270.73
215_G238_Q0.5260.73
84_I95_V0.5250.73
309_Q313_L0.5240.73
12_H279_D0.5240.73
4_T91_G0.5230.72
99_F102_G0.5220.72
201_A206_S0.5210.72
76_C119_V0.5210.72
16_D70_L0.5190.72
218_R243_E0.5160.71
236_A239_Q0.5160.71
223_V262_P0.5150.71
117_E162_Q0.5150.71
13_R97_L0.5150.71
96_E165_A0.5140.71
235_L271_I0.5120.71
12_H248_S0.5120.71
59_F172_E0.5110.71
284_G289_H0.5110.71
294_A305_I0.5100.71
277_T287_I0.5090.70
199_G249_N0.5080.70
204_P207_I0.5070.70
236_A270_G0.5070.70
32_N35_L0.5060.70
112_V115_V0.5040.70
68_K107_A0.5030.70
274_S308_A0.5010.69
248_S283_Q0.5010.69
203_G206_S0.5000.69
172_E206_S0.5000.69
203_G224_K0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iarA 1 0.988 100 0.274 Contact Map
2pgfA 1 0.985 100 0.278 Contact Map
3rysA 1 0.985 100 0.284 Contact Map
3lgdA 2 0.997 100 0.295 Contact Map
3paoA 1 0.9399 100 0.327 Contact Map
2a3lA 3 0.961 100 0.336 Contact Map
4gxwA 1 0.976 100 0.369 Contact Map
1p1mA 2 0.8258 99.5 0.818 Contact Map
3lnpA 2 0.8348 99.5 0.823 Contact Map
4r85A 4 0.8829 99.4 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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