GREMLIN Database
GABT - 4-aminobutyrate aminotransferase GabT
UniProt: P22256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10361
Length: 426 (383)
Sequences: 20916 (12401)
Seq/√Len: 633.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_E71_K4.3171.00
226_R230_D4.0951.00
383_K419_Q4.0121.00
34_R42_E3.6161.00
184_I224_R3.6111.00
330_K411_R3.4051.00
92_I313_K3.2131.00
29_R36_W3.1071.00
250_T256_Q2.9001.00
319_N322_Q2.8941.00
330_K407_D2.8001.00
61_K317_Q2.7701.00
64_A68_A2.6811.00
341_K418_S2.6491.00
323_K327_L2.5951.00
406_E409_Q2.5491.00
46_F413_G2.3781.00
92_I316_E2.3541.00
310_E313_K2.3471.00
334_G414_L2.3461.00
224_R227_A2.3161.00
61_K310_E2.2811.00
379_R382_D2.2611.00
227_A231_E2.2571.00
326_D407_D2.2461.00
61_K314_V2.2321.00
28_D38_V2.2031.00
59_H314_V2.1981.00
34_R409_Q2.1931.00
188_H231_E2.1801.00
383_K423_E2.1111.00
379_R423_E2.0511.00
36_W42_E2.0491.00
342_H418_S2.0091.00
385_L416_I1.9571.00
334_G411_R1.9551.00
204_V237_I1.9451.00
92_I309_L1.9271.00
89_L308_A1.9001.00
379_R383_K1.8431.00
346_G360_F1.8201.00
63_V67_E1.8161.00
104_K283_A1.8161.00
329_Q333_D1.8101.00
283_A287_D1.8071.00
332_K336_L1.8011.00
84_E88_E1.7971.00
37_D41_R1.7911.00
187_I225_L1.7871.00
314_V318_E1.7781.00
412_Q416_I1.7701.00
91_E95_Q1.7691.00
28_D72_K1.7671.00
130_G199_D1.7661.00
66_V307_A1.7621.00
203_I229_C1.7611.00
108_V277_A1.7471.00
41_R384_G1.7321.00
205_I225_L1.7261.00
103_K283_A1.7041.00
188_H192_K1.7001.00
34_R412_Q1.6571.00
66_V70_L1.6521.00
31_E60_P1.6511.00
180_E186_S1.6251.00
115_V265_T1.6141.00
332_K350_G1.6021.00
342_H422_D1.5991.00
334_G337_A1.5981.00
266_F278_G1.5811.00
191_F234_I1.5641.00
250_T325_N1.5511.00
96_K316_E1.5411.00
334_G415_E1.5401.00
327_L330_K1.5321.00
134_F221_F1.5311.00
42_E412_Q1.5211.00
271_A276_L1.5091.00
90_C107_L1.4871.00
125_A285_V1.4821.00
33_C409_Q1.4781.00
327_L410_I1.4701.00
68_A72_K1.4701.00
97_V280_T1.4631.00
182_D218_S1.4511.00
220_A223_Q1.4381.00
33_C404_T1.4331.00
332_K355_I1.4251.00
238_A254_M1.4241.00
92_I95_Q1.4221.00
380_A387_L1.4201.00
185_A189_R1.4161.00
266_F280_T1.4021.00
131_T202_A1.3991.00
132_I200_I1.3971.00
37_D43_Y1.3921.00
379_R420_C1.3911.00
310_E314_V1.3861.00
188_H224_R1.3801.00
88_E309_L1.3781.00
383_K420_C1.3741.00
323_K326_D1.3671.00
226_R236_L1.3651.00
105_T280_T1.3591.00
226_R229_C1.3561.00
122_A237_I1.3451.00
117_N279_V1.3371.00
330_K334_G1.3331.00
309_L313_K1.3321.00
60_P64_A1.3311.00
27_A35_V1.3301.00
270_I276_L1.3261.00
118_A265_T1.3251.00
119_V131_T1.3241.00
276_L305_C1.3221.00
334_G418_S1.3151.00
336_L339_A1.3141.00
59_H318_E1.3041.00
88_E313_K1.3001.00
185_A188_H1.2951.00
192_K232_H1.2941.00
405_I410_I1.2921.00
184_I228_L1.2901.00
250_T255_E1.2891.00
418_S422_D1.2881.00
180_E183_A1.2821.00
338_I414_L1.2811.00
94_N105_T1.2801.00
125_A288_A1.2731.00
29_R72_K1.2701.00
203_I225_L1.2691.00
322_Q326_D1.2661.00
205_I222_M1.2661.00
251_L255_E1.2641.00
66_V303_I1.2531.00
327_L407_D1.2481.00
95_Q316_E1.2451.00
263_L281_G1.2421.00
238_A259_V1.2411.00
115_V204_V1.2391.00
14_A94_N1.2371.00
31_E58_L1.2361.00
270_I278_G1.2351.00
220_A257_M1.2321.00
254_M264_T1.2241.00
338_I418_S1.2221.00
257_M351_L1.2211.00
64_A67_E1.2181.00
276_L308_A1.2061.00
188_H228_L1.1961.00
130_G166_V1.1951.00
104_K287_D1.1871.00
126_T201_A1.1781.00
65_A310_E1.1771.00
55_T314_V1.1741.00
14_A91_E1.1741.00
260_A282_R1.1661.00
313_K317_Q1.1631.00
380_A416_I1.1631.00
223_Q227_A1.1601.00
108_V279_V1.1571.00
256_Q351_L1.1561.00
409_Q412_Q1.1551.00
63_V70_L1.1441.00
63_V71_K1.1371.00
58_L63_V1.1351.00
148_L204_V1.1241.00
67_E70_L1.1201.00
148_L165_H1.1181.00
128_R233_G1.1151.00
415_E419_Q1.1131.00
107_L305_C1.1071.00
31_E42_E1.1061.00
34_R44_L1.1001.00
263_L279_V1.1001.00
385_L413_G1.0941.00
380_A420_C1.0861.00
188_H232_H1.0831.00
407_D411_R1.0751.00
325_N329_Q1.0731.00
119_V148_L1.0721.00
246_G321_L1.0711.00
333_D337_A1.0691.00
223_Q258_G1.0671.00
183_A186_S1.0631.00
321_L324_A1.0621.00
112_S145_T1.0601.00
272_G311_V1.0411.00
380_A385_L1.0401.00
252_F266_F1.0341.00
383_K416_I1.0331.00
89_L309_L1.0291.00
229_C234_I1.0281.00
28_D84_E1.0231.00
235_M285_V1.0221.00
33_C44_L1.0181.00
62_V307_A1.0151.00
412_Q415_E1.0151.00
314_V317_Q1.0141.00
188_H227_A1.0021.00
121_I279_V0.9961.00
179_S190_I0.9961.00
411_R415_E0.9871.00
28_D40_G0.9821.00
133_A204_V0.9811.00
225_L236_L0.9731.00
208_V351_L0.9671.00
315_F320_L0.9631.00
249_G255_E0.9621.00
133_A167_Y0.9591.00
55_T311_V0.9581.00
114_A265_T0.9581.00
96_K251_L0.9571.00
31_E36_W0.9431.00
323_K407_D0.9411.00
356_A396_V0.9391.00
306_V310_E0.9361.00
339_A345_I0.9331.00
54_N269_S0.9311.00
315_F321_L0.9301.00
227_A230_D0.9291.00
191_F200_I0.9271.00
134_F217_S0.9251.00
26_F38_V0.9221.00
99_G264_T0.9191.00
346_G358_E0.9191.00
179_S183_A0.9171.00
207_P238_A0.9171.00
186_S189_R0.9151.00
408_A411_R0.9111.00
222_M257_M0.9101.00
228_L232_H0.9061.00
375_E379_R0.9041.00
53_L272_G0.8991.00
92_I96_K0.8961.00
28_D36_W0.8941.00
197_P232_H0.8931.00
44_L409_Q0.8901.00
347_D358_E0.8891.00
245_A315_F0.8881.00
219_P223_Q0.8871.00
358_E395_N0.8861.00
33_C406_E0.8851.00
336_L340_E0.8851.00
320_L324_A0.8831.00
68_A71_K0.8801.00
98_P254_M0.8791.00
135_S180_E0.8761.00
322_Q325_N0.8751.00
61_K64_A0.8741.00
147_A162_M0.8731.00
202_A237_I0.8721.00
112_S142_T0.8691.00
64_A71_K0.8681.00
256_Q325_N0.8651.00
378_A382_D0.8581.00
44_L412_Q0.8541.00
216_A351_L0.8531.00
61_K313_K0.8511.00
109_T113_E0.8481.00
46_F385_L0.8451.00
26_F87_L0.8451.00
46_F405_I0.8441.00
55_T62_V0.8401.00
130_G192_K0.8311.00
118_A237_I0.8291.00
233_G284_E0.8281.00
121_I281_G0.8261.00
122_A202_A0.8241.00
405_I413_G0.8171.00
354_M400_L0.8171.00
179_S182_D0.8161.00
125_A235_M0.8161.00
334_G410_I0.8151.00
99_G103_K0.8151.00
96_K312_L0.8121.00
341_K422_D0.8101.00
33_C402_P0.8091.00
328_G332_K0.8071.00
338_I342_H0.8061.00
38_V84_E0.8061.00
68_A306_V0.8041.00
353_A405_I0.8021.00
230_D260_A0.8011.00
226_R259_V0.7991.00
74_S274_F0.7981.00
122_A235_M0.7971.00
321_L325_N0.7961.00
130_G200_I0.7951.00
220_A224_R0.7951.00
337_A341_K0.7931.00
108_V114_A0.7931.00
243_S354_M0.7921.00
245_A312_L0.7901.00
129_S199_D0.7891.00
333_D336_L0.7881.00
126_T233_G0.7861.00
274_F304_A0.7811.00
32_N404_T0.7811.00
217_S220_A0.7811.00
203_I234_I0.7801.00
61_K65_A0.7791.00
251_L321_L0.7791.00
27_A30_A0.7731.00
399_I417_I0.7721.00
88_E92_I0.7711.00
105_T278_G0.7701.00
245_A270_I0.7701.00
326_D330_K0.7661.00
208_V354_M0.7641.00
191_F228_L0.7571.00
89_L305_C0.7571.00
187_I203_I0.7541.00
186_S190_I0.7531.00
85_P306_V0.7511.00
230_D236_L0.7501.00
296_G299_A0.7451.00
224_R228_L0.7431.00
51_A400_L0.7431.00
119_V204_V0.7421.00
374_A378_A0.7421.00
252_F264_T0.7421.00
254_M259_V0.7401.00
419_Q423_E0.7391.00
44_L413_G0.7381.00
359_L376_I0.7331.00
122_A263_L0.7321.00
93_M280_T0.7311.00
216_A350_G0.7301.00
376_I417_I0.7291.00
210_G242_Q0.7281.00
110_T113_E0.7271.00
229_C236_L0.7261.00
62_V272_G0.7251.00
349_R358_E0.7231.00
337_A340_E0.7221.00
65_A307_A0.7211.00
181_D217_S0.7211.00
196_A199_D0.7211.00
245_A266_F0.7211.00
337_A418_S0.7171.00
330_K333_D0.7161.00
348_V355_I0.7151.00
207_P222_M0.7141.00
251_L316_E0.7141.00
48_G400_L0.7131.00
245_A251_L0.7121.00
200_I234_I0.7101.00
124_A293_G0.7061.00
208_V248_T0.7051.00
266_F270_I0.7041.00
248_T256_Q0.7021.00
47_A388_L0.7021.00
376_I420_C0.7011.00
413_G416_I0.7001.00
92_I312_L0.6991.00
324_A328_G0.6981.00
70_L303_I0.6971.00
326_D329_Q0.6961.00
179_S186_S0.6961.00
86_Y90_C0.6961.00
98_P255_E0.6941.00
350_G355_I0.6941.00
210_G354_M0.6941.00
267_A277_A0.6941.00
284_E287_D0.6911.00
85_P309_L0.6891.00
155_Y159_M0.6871.00
377_V389_S0.6871.00
98_P260_A0.6861.00
129_S164_G0.6791.00
121_I289_V0.6791.00
41_R382_D0.6781.00
15_I90_C0.6771.00
99_G260_A0.6761.00
132_I187_I0.6761.00
83_Y86_Y0.6731.00
85_P89_L0.6711.00
181_D224_R0.6691.00
72_K84_E0.6681.00
120_K294_L0.6681.00
348_V357_I0.6681.00
117_N294_L0.6671.00
223_Q257_M0.6671.00
58_L70_L0.6651.00
138_Y141_R0.6641.00
358_E396_V0.6631.00
115_V145_T0.6631.00
69_Q72_K0.6631.00
408_A412_Q0.6621.00
108_V113_E0.6601.00
44_L385_L0.6591.00
35_V386_I0.6581.00
327_L353_A0.6571.00
281_G286_M0.6541.00
205_I236_L0.6531.00
236_L259_V0.6521.00
85_P305_C0.6521.00
237_I263_L0.6511.00
209_Q212_G0.6501.00
96_K252_F0.6471.00
89_L276_L0.6451.00
328_G350_G0.6451.00
97_V264_T0.6431.00
30_A73_L0.6431.00
55_T320_L0.6421.00
397_L417_I0.6421.00
290_A293_G0.6421.00
222_M238_A0.6421.00
380_A417_I0.6391.00
330_K410_I0.6381.00
125_A284_E0.6381.00
359_L421_F0.6381.00
191_F232_H0.6371.00
85_P88_E0.6361.00
339_A348_V0.6341.00
323_K410_I0.6331.00
246_G315_F0.6331.00
181_D185_A0.6301.00
342_H421_F0.6301.00
323_K406_E0.6291.00
82_A87_L0.6251.00
399_I413_G0.6241.00
99_G254_M0.6241.00
327_L405_I0.6241.00
376_I380_A0.6211.00
241_V265_T0.6191.00
414_L418_S0.6191.00
357_I417_I0.6171.00
127_K199_D0.6161.00
331_L414_L0.6151.00
73_L76_T0.6111.00
118_A263_L0.6101.00
63_V274_F0.6091.00
285_V288_A0.6081.00
30_A35_V0.6071.00
121_I263_L0.6061.00
144_Y162_M0.6051.00
134_F225_L0.6041.00
184_I188_H0.6021.00
245_A252_F0.6001.00
219_P351_L0.6001.00
219_P257_M0.5971.00
62_V311_V0.5961.00
331_L355_I0.5961.00
420_C423_E0.5951.00
127_K130_G0.5941.00
42_E416_I0.5941.00
209_Q215_Y0.5931.00
128_R234_I0.5931.00
359_L372_L0.5901.00
331_L410_I0.5891.00
327_L406_E0.5881.00
14_A87_L0.5881.00
97_V252_F0.5881.00
111_G241_V0.5861.00
33_C405_I0.5861.00
385_L412_Q0.5861.00
54_N403_L0.5851.00
187_I228_L0.5841.00
94_N103_K0.5841.00
132_I190_I0.5831.00
69_Q85_P0.5821.00
97_V266_F0.5811.00
62_V310_E0.5811.00
89_L107_L0.5801.00
324_A403_L0.5791.00
155_Y158_G0.5781.00
87_L91_E0.5781.00
26_F82_A0.5771.00
180_E184_I0.5771.00
47_A386_I0.5761.00
307_A310_E0.5761.00
187_I224_R0.5751.00
254_M261_P0.5751.00
65_A68_A0.5741.00
16_P281_G0.5741.00
70_L307_A0.5731.00
344_E360_F0.5731.00
417_I421_F0.5731.00
154_P159_M0.5721.00
329_Q332_K0.5711.00
267_A298_Y0.5701.00
282_R285_V0.5701.00
123_R143_H0.5681.00
54_N315_F0.5671.00
66_V74_S0.5671.00
375_E378_A0.5661.00
207_P254_M0.5651.00
230_D284_E0.5641.00
416_I420_C0.5631.00
48_G402_P0.5631.00
152_V156_S0.5611.00
339_A347_D0.5611.00
28_D31_E0.5611.00
251_L312_L0.5611.00
134_F179_S0.5601.00
184_I225_L0.5591.00
203_I230_D0.5581.00
216_A257_M0.5571.00
96_K250_T0.5571.00
29_R42_E0.5561.00
162_M165_H0.5541.00
345_I421_F0.5541.00
94_N280_T0.5531.00
357_I399_I0.5521.00
207_P243_S0.5501.00
156_S159_M0.5501.00
228_L231_E0.5491.00
416_I419_Q0.5481.00
373_T389_S0.5481.00
372_L375_E0.5471.00
309_L316_E0.5471.00
331_L334_G0.5471.00
324_A353_A0.5461.00
153_N156_S0.5441.00
330_K414_L0.5431.00
211_E398_R0.5421.00
123_R160_G0.5410.99
30_A53_L0.5400.99
242_Q398_R0.5390.99
134_F181_D0.5390.99
405_I409_Q0.5390.99
316_E319_N0.5380.99
187_I221_F0.5350.99
128_R199_D0.5340.99
134_F205_I0.5330.99
301_N304_A0.5330.99
65_A313_K0.5330.99
381_R386_I0.5330.99
94_N99_G0.5330.99
385_L420_C0.5320.99
404_T409_Q0.5310.99
44_L405_I0.5310.99
25_I28_D0.5300.99
251_L315_F0.5300.99
376_I397_L0.5300.99
63_V272_G0.5290.99
70_L74_S0.5290.99
31_E34_R0.5280.99
334_G338_I0.5260.99
69_Q73_L0.5260.99
189_R192_K0.5260.99
413_G417_I0.5250.99
345_I357_I0.5230.99
119_V144_Y0.5210.99
55_T59_H0.5200.99
25_I381_R0.5200.99
349_R356_A0.5190.99
158_G161_L0.5180.99
97_V105_T0.5170.99
310_E317_Q0.5160.99
329_Q336_L0.5160.99
15_I86_Y0.5160.99
72_K85_P0.5160.99
242_Q354_M0.5160.99
27_A73_L0.5140.99
410_I413_G0.5130.99
185_A224_R0.5130.99
378_A381_R0.5120.99
339_A421_F0.5120.99
62_V66_V0.5110.99
371_K375_E0.5110.99
384_G416_I0.5060.99
377_V381_R0.5060.99
166_V190_I0.5060.99
225_L234_I0.5060.99
412_Q419_Q0.5050.99
192_K198_E0.5050.99
402_P405_I0.5040.99
141_R295_G0.5020.99
94_N97_V0.5010.99
376_I421_F0.5010.99
192_K199_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oksA 2 0.9883 100 0.348 Contact Map
4atqA 7 0.9906 100 0.351 Contact Map
1sffA 3 0.9953 100 0.364 Contact Map
4a0gA 2 0.9624 100 0.365 Contact Map
4ffcA 4 0.9836 100 0.365 Contact Map
4uoxA 3 0.9507 100 0.366 Contact Map
4e3qA 3 0.9789 100 0.37 Contact Map
2epjA 2 0.9437 100 0.377 Contact Map
1z7dA 2 0.8709 100 0.383 Contact Map
2ykyA 4 0.9225 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0128 seconds.